Marie Barro

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Lingxiao HePhilipe de Souto BarretoJuan Luis Sánchez SánchezYves RollandSophie GuyonnetAngelo PariniAlexandre LucasBruno VellasBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsCarole BadufleAudrey ZuerasChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie Noëlle-CuffCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick Gasnier And Serge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-Abbal
• Organismes : Xiamen University Institut du Vieillissement Institut du Vieillissement Equipe Vieillissement (CERPOP) Institut du Vieillissement Universidad Europea de Madrid = European University of Madrid Institut du Vieillissement Equipe Vieillissement (CERPOP) Institut du Vieillissement Equipe Vieillissement (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Institut du Vieillissement Equipe Vieillissement (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Background Growth differentiation factor 15 (GDF15) has been associated with several age-related disorders, but its associations with functional abilities in community-dwelling older adults are not well studied. Methods The study was a secondary analysis of 1 096 community-dwelling older adults (aged 69–94 years) recruited from the Multidomain Alzheimer’s Preventive Trial. Plasma GDF15 was measured 1 year after participants’ enrollment. Annual data of physical performance (grip strength and Short Physical Performance Battery [SPPB]) and global cognitive functions (Mini-Mental State Examination [MMSE] and a composite cognitive score) were measured for 4 years. Adjusted mixed-effects linear models were performed for cross-sectional and longitudinal association analyses. Results A higher GDF15 was cross-sectionally associated with a weaker grip strength (β = −1.1E−03, 95% CI [−2.0E−03, −1.5E−04]), a lower SPPB score (β = −3.1E−04, 95% CI [−5.4E−04, −9.0E−05]), and worse cognitive functions (β = −2.4E−04, 95% CI [−3.3E−04, −1.6E−04] for composite cognitive score; β = −4.0E−04, 95% CI [−6.4E−04, −1.6E−04] for MMSE). Participants with higher GDF15 demonstrated greater longitudinal declines in SPPB (β = −1.0E−04, 95% CI [−1.7E−04, −2.0E−05]) and composite cognitive score (β = −2.0E−05, 95% CI [−4.0E−05, −3.6E−06]). The optimal initial GDF15 cutoff values for identifying participants with minimal clinically significant decline after 1 year were 2 189 pg/mL for SPPB (AUC: 0.580) and 2 330 pg/mL for composite cognitive score (AUC: 0.587). Conclusions Plasma GDF15 is cross-sectionally and longitudinally associated with lower-limb physical performance and global cognitive function in older adults. Circulating GDF15 alone has a limited capacity of discriminating older adults who will develop clinically significant functional declines. Clinical Trial Registration NCT00672685

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Leonardo BencivengaMathilde StrumiaYves RollandLaurent MartinezPhilippe CestacSophie GuyonnetSandrine AndrieuAngelo PariniAlexandre LucasBruno VellasPhilipe de Souto BarretoLaure RouchBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Equipe Vieillissement (CERPOP) "Federico II" University of Naples Medical School Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Université Toulouse III - Paul Sabatier Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP)
• Publié dans GeroScience le 30/10/2020

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Résumé : Most physiopathological mechanisms underlying blood pressure variability (BPV) are implicated in aging. Vascular aging is associated with chronic low-grade inflammation occurring in late life, known as "inflammaging" and the hallmark "mitochondrial dysfunction" due to age-related stress. We aimed to determine whether plasma levels of the pleiotropic stress-related mitokine growth/differentiation factor 15 (GDF-15) and two inflammatory biomarkers, interleukin 6 (IL-6) and tumor necrosis factor receptor 1 (TNFR-1), are associated with visit-to-visit BPV in a population of community-dwelling older adults. The study population consisted of 1096 community-dwelling participants [median age 75 (72-78) years; 699 females, 63.7%] aged ≥ 70 years from the MAPT study. Plasma blood sample was collected 12 months after enrolment and BP was assessed up to seven times over a 4-year period. Systolic (SBPV) and diastolic BPV (DBPV) were determined through several indicators taking into account BP change over time, the order of measurements and formulas independent of mean BP levels. Higher values of GDF-15 were significantly associated with increased SBPV (all indicators) after adjustment for relevant covariates [adjusted 1-SD increase in GDF-15: β (SE) = 0.07 (0.04), p < 0.044, for coefficient of variation%]. GDF-15 levels were not associated with DBPV. No significant associations were found between IL-6 and BPV, whereas TNFR1 was only partially related to DBPV. Unlike inflammation biomarkers, higher GDF-15 levels were associated with greater SBPV. Our findings support the age-related process of mitochondrial dysfunction underlying BP instability, suggesting that BPV might be a potential marker of aging.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luc Molet-BenhamouKelly Virecoulon GiudiciPhilipe de Souto BarretoChristelle CantetYves RollandBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie-Paule Boncoeur-MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Gérontopôle Gérontopôle Gérontopôle Equipe Vieillissement (CERPOP) Gérontopôle Equipe SPHERE (CERPOP) Gérontopôle Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract Long-term use of urate-lowering therapies (ULT) may reduce inflammaging and thus prevent cognitive decline during aging. This article examined the association between long-term use of ULT and cognitive decline among community-dwelling older adults with spontaneous memory complaints. We performed a secondary observational analysis using data of 1673 participants ≥ 70 years old from the Multidomain Alzheimer Preventive Trial (MAPT Study), a randomized controlled trial assessing the effect of a multidomain intervention, the administration of polyunsaturated fatty acids (PUFA), both, or placebo on cognitive decline. We compared cognitive decline during the 5-year follow-up between three groups according to ULT (i.e. allopurinol and febuxostat) use: participants treated with ULT during at least 75% of the study period (PT ≥ 75; n = 51), less than 75% (PT < 75; n = 31), and non-treated participants (PNT; n = 1591). Cognitive function (measured by a composite score) was assessed at baseline, 6 months and every year for 5 years. Linear mixed models were performed and results were adjusted for age, sex, body mass index (BMI), diagnosis of arterial hypertension or diabetes, baseline composite cognitive score, and MAPT intervention groups. After the 5-year follow-up, only non-treated participants presented a significant decline in the cognitive composite score (mean change − 0.173, 95%CI − 0.212 to − 0.135; p < 0.0001). However, there were no differences in change of the composite cognitive score between groups (adjusted between-group difference for PT ≥ 75 vs. PNT: 0.144, 95%CI − 0.075 to 0.363, p = 0.196; PT < 75 vs. PNT: 0.103, 95%CI − 0.148 to 0.353, p = 0.421). Use of ULT was not associated with reduced cognitive decline over a 5-year follow-up among community-dwelling older adults at risk of dementia.

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Fichiers liés : MOLET‑BENHAMOU_2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2022
• Auteurs : Mariam BarroIssa WonniMarie SimoninAbalo Itolou KassankognoAgnieszka KlonowskaLionel MoulinGilles BénaIrénée SomdaCaroline BrunelCharlotte Tollenaere
• Organismes : Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Université Nazi Boni (Bobo-Dioulasso) Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Institut de Recherche en Horticulture et Semences Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Plant Health Institute of Montpellier Plant Health Institute of Montpellier Université Nazi Boni (Bobo-Dioulasso) Fonctionnement agroécologique et performances des systèmes de cultures horticoles Département Performances des systèmes de production et de transformation tropicaux Plant Health Institute of Montpellier
• Publié dans FEMS Microbiology Ecology le 24/10/2020

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Résumé : Due to their potential applications for food safety, there is a growing interest in rice root-associated microbial communities, but some systems remain understudied. Here, we compare the assemblage of root-associated microbiota in rice sampled in 19 small farmer's fields from irrigated and rainfed lowlands in Burkina Faso, using an amplicon metabarcoding approach of the 16S rRNA gene (prokaryotes, three plant samples per field) and ITS (fungi, one sample per field). In addition to the expected structure by root compartments (root vs rhizosphere) and geographical zones, we showed that the rice production system is a major driver of microbiome structure. In irrigated systems, we found a higher diversity of prokaryotic communities from the rhizosphere and more complex co-occurrence networks, compared to rainfed lowlands, while fungal communities exhibited an opposite pattern (higher richness in rainfed lowlands). Core taxa were different between the two systems, and indicator species were identified: mostly within Bacillaceae in rainfed lowlands, and within Burkholderiaceae and Moraxellaceae in irrigated areas. Finally, a higher abundance in rainfed lowlands was found for mycorrhizal fungi (both compartments) and rhizobia (rhizosphere only). Our results highlight deep microbiome differences induced by contrasted rice production systems that should consequently be considered for microbial engineering applications.

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Fichiers liés : 2022.03.29.486073.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Jérémy RaffinDavide AngioniKelly GiudiciPhilippe ValetGeetika AggarwalAndrew NguyenJohn MorleySophie GuyonnetYves RollandBruno VellasPhilipe de Souto BarretoBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalSandrine AndrieuChristelle CantetNicola Coley
• Organismes : Institut universitaire de France Institut universitaire de France Institut universitaire de France Geroscience and rejuvenation research center Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Institut universitaire de France Equipe Vieillissement (CERPOP) Institut universitaire de France Equipe Vieillissement (CERPOP) Institut universitaire de France Equipe Vieillissement (CERPOP) Institut universitaire de France Centre d'Epidémiologie et de Recherche en santé des POPulations
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Physical activity (PA) has been shown to moderate the negative effects of obesity on pro-inflammatory cytokines but its relationship with the adipokine progranulin (PGRN) remains poorly investigated. This study aimed to examine the cross-sectional main and interactive associations of body mass index (BMI) and PA level with circulating PGRN in older adults. Five-hundred and twelve participants aged 70 years and older involved in the Multidomain Alzheimer Preventive Trial (MAPT) study who underwent plasma PGRN measurements (ng/mL) were included. Self-reported PA levels were assessed using questionnaires. People were classified into 3 BMI categories: normal weight, overweight, or obesity. Further categorization using PA tertiles was used to define highly active, moderately active, and low active individuals. Multiple linear regressions were performed in order to test the associations of BMI, PA level, and their interaction with PGRN levels. Multiple linear regressions adjusted by age, sex, diabetes mellitus status, total cholesterol, creatinine level, and MAPT group demonstrated significant interactive associations of BMI status and continuous PA such that in people without obesity, higher PA levels were associated with lower PGRN concentrations, while an opposite pattern was found in individuals with obesity. In addition, continuous BMI was positively associated with circulating PGRN in highly active individuals but not in their less active peers. This cross-sectional study demonstrated reverse patterns in older adults with obesity compared to those without obesity regarding the relationships between PA and PGRN levels. Longitudinal and experimental investigations are required to understand the mechanisms that underlie the present findings. Clinical Trials Registration Number: NCT00672685

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2022
• Auteurs : Wan-Hsuan LuKelly Virecoulon GiudiciJohn MorleySophie GuyonnetAngelo PariniGeetika AggarwalAndrew NguyenYan LiRandall BatemanBruno VellasPhilipe de Souto BarretoBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFranҫoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanYves RollandCharlotte DupuyCéline CaillaudPierre-Jean OussetFranҫoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie-Noëlle CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFranҫoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFranҫois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFranҫois CholletPierre PayouxThierry VoisinJulien DelrieuSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Centre d'Epidémiologie et de Recherche en santé des POPulations Centre Hospitalier Universitaire de Toulouse Washington University School of Medicine [Saint Louis, MO] Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Washington University School of Medicine [Saint Louis, MO] Saint Louis University Washington University School of Medicine [Saint Louis, MO] Saint Louis University Washington University School of Medicine [Saint Louis, MO] Washington University School of Medicine [Saint Louis, MO] Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP)
• Publié dans GeroScience le 30/10/2020

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Résumé : We investigated combining a core AD neuropathology measure (plasma amyloid-beta [Aβ] 42/40) with five plasma markers of inflammation, cellular stress, and neurodegeneration to predict cognitive decline. Among 401 participants free of dementia (median [IQR] age, 76 [73-80] years) from the Multidomain Alzheimer Preventive Trial (MAPT), 28 (7.0%) participants developed dementia, and 137 (34.2%) had worsening of clinical dementia rating (CDR) scale over 4 years. In the models utilizing plasma Aβ alone, a tenfold increased risk of incident dementia (nonsignificant) and a fivefold increased risk of worsening CDR were observed as each nature log unit increased in plasma Aβ levels. Models incorporating Aβ plus multiple plasma biomarkers performed similarly to models included Aβ alone in predicting dementia and CDR progression. However, improving Aβ model performance for composite cognitive score (CCS) decline, a proxy of dementia, was observed after including plasma monocyte chemoattractant protein 1 (MCP1) and growth differentiation factor 15 (GDF15) as covariates. Participants with abnormal Aβ, GDF15, and MCP1 presented higher CCS decline (worsening cognitive function) compared to their normal-biomarker counterparts (adjusted β [95% CI], - 0.21 [- 0.35 to - 0.06], p = 0.005). In conclusion, our study found limited added values of multi-biomarkers beyond the basic Aβ models for predicting clinically meaningful cognitive decline among non-demented older adults. However, a combined assessment of inflammatory and cellular stress status with Aβ pathology through measuring plasma biomarkers may improve the evaluation of cognitive performance.

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• Type de publi. : Article dans une revue
• Date de publi. : 13/01/2022
• Auteurs : Alassane OuattaraFidèle TiendrébéogoNathalie BeckerCica UrbinoGaël ThébaudMurielle HoareauAgathe AllibertFrédéric ChiroleuMarie-Stéphanie VernereyEdgar Valentin TraoréNicolas BarroOumar TraoréPierre LefeuvreJean-Michel Lett
• Organismes : Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Peuplements végétaux et bioagresseurs en milieu tropical Université Joseph Ki-Zerbo [Université de Ouagadougou, Burkina Faso] LMI Patho-Bios Institut de l'Environnement et Recherches Agricoles [Ouagadougou] LMI Patho-Bios Institut de Systématique, Evolution, Biodiversité Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Université Joseph Ki-Zerbo [Université de Ouagadougou, Burkina Faso] Institut de l'Environnement et Recherches Agricoles [Ouagadougou] Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques
• Publié dans Scientific Reports le 26/10/2020

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Résumé : In recent decades, a legion of monopartite begomoviruses transmitted by the whitefly Bemisia tabaci has emerged as serious threats to vegetable crops in Africa. Recent studies in Burkina Faso (West Africa) reported the predominance of pepper yellow vein Mali virus (PepYVMLV) and its frequent association with a previously unknown DNA-B component. To understand the role of this DNA-B component in the emergence of PepYVMLV, we assessed biological traits related to virulence, virus accumulation, location in the tissue and transmission. We demonstrate that the DNA-B component is not required for systemic movement and symptom development of PepYVMLV (non-strict association), but that its association produces more severe symptoms including growth arrest and plant death. The increased virulence is associated with a higher viral DNA accumulation in plant tissues, an increase in the number of contaminated nuclei of the phloem parenchyma and in the transmission rate by B. tabaci. Our results suggest that the association of a DNA-B component with the otherwise monopartite PepYVMLV is a key factor of its emergence.

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Fichiers liés : s41598-021-03957-7.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/01/2022
• Auteurs : Juan Luis Sanchez-SanchezKelly V GiudiciSophie GuyonnetJulien DelrieuYan LiRandall J BatemanAngelo PariniBruno VellasPhilipe de Souto BarretoBruno VellasSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Universidad Europea de Madrid = European University of Madrid Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Washington University School of Medicine in St. Louis Washington University School of Medicine in St. Louis Université Toulouse III - Paul Sabatier Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse
• Publié dans Alzheimer's Research and Therapy le 23/10/2020

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Résumé : Background: Monocyte Chemoattractant Protein-1 (MCP-1), a glial-derived chemokine, mediates neuroinflammation and may regulate memory outcomes among older adults. We aimed to explore the associations of plasma MCP-1 levels (alone and in combination with β-amyloid deposition-Aβ42/40) with overall and domain-specific cognitive evolution among older adults. Methods: Secondary analyses including 1097 subjects (mean age = 75.3 years ± 4.4; 63.8% women) from the Multidomain Alzheimer Preventive Trial (MAPT). MCP-1 (higher is worse) and Aβ42/40 (lower is worse) were measured in plasma collected at year 1. MCP-1 in continuous and as a dichotomy (values in the highest quartile (MCP-1+)) were used, as well as a dichotomy of Aβ42/40. Outcomes were measured annually over 4 years and included the following: cognitive composite z-score (CCS), the Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR) sum of boxes (overall cognitive function); composite executive function z-score, composite attention z-score, Free and Cued Selective Reminding Test (FCSRT - memory). Results: Plasma MCP-1 as a continuous variable was associated with the worsening of episodic memory over 4 years of follow-up, specifically in measures of free and cued delayed recall. MCP-1+ was associated with worse evolution in the CCS (4-year between-group difference: β = -0.14, 95%CI = -0.26, -0.02) and the CDR sum of boxes (2-year: β = 0.19, 95%CI = 0.06, 0.32). In domain-specific analyses, MCP-1+ was associated with declines in the FCSRT delayed recall sub-domains. In the presence of low Aβ42/40, MCP-1+ was not associated with greater declines in cognitive functions. The interaction with continuous biomarker values Aβ42/40× MCP-1 × time was significant in models with CDR sum of boxes and FCSRT DTR as dependent variables. Conclusions: Baseline plasma MCP-1 levels were associated with longitudinal declines in overall cognitive and episodic memory performance in older adults over a 4-year follow-up. How plasma MCP-1 interacts with Aβ42/40 to determine cognitive decline at different stages of cognitive decline/dementia should be clarified by further research. The MCP-1 association on cognitive decline was strongest in those with amyloid plaques, as measured by blood plasma Aβ42/40.

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Fichiers liés : SANCHEZ-SANCHEZ_2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Steven L. FinkelsteinMicaela B. BagleyPablo Arrabal HaroMark DickinsonHenry C. FergusonJeyhan S. KartaltepeCasey PapovichDenis BurgarellaDale D. KocevskiMarc Huertas-CompanyKartheik G. IyerAnton M. KoekemoerRebecca L. LarsonPablo G. Pérez-GonzálezCaitlin RoseSandro TacchellaStephen M. WilkinsKatherine ChworowskyAubrey MedranoAlexa M. MoralesRachel S. SomervilleL. Y. Aaron YungAdriano FontanaMauro GiavaliscoAndrea GrazianNorman A. GroginLisa J. KewleyAllison KirkpatrickPeter KurczynskiJennifer M. LotzLaura PentericciNor PirzkalSwara RavindranathRussell E. RyanJonathan R. TrumpGuang YangOmar AlmainiRicardo O. AmorínMarianna AnnunziatellaBren E. BackhausGuillermo BarroPeter BehrooziEric F. BellRachana BhatawdekarLaura BisigelloVolker BrommVéronique BuatFernando BuitragoAntonello CalabròCaitlin M. CaseyMarco CastellanoÓscar A. Chávez OrtizLaure CieslaNikko J. CleriSeth H. CohenJustin W. ColeKevin C. CookeM. C. CooperAsantha R. CoorayLuca CostantinIsabella G. CoxDarren CrotonEmanuele DaddiRomeel DavéAlexander de La VegaAvishai DekelDavid ElbazVicente Estrada-CarpenterSandra M. FaberVital FernándezKeely D. FinkelsteinJonathan FreundlichSeiji FujimotoÁngela García-ArgumánezJonathan P. GardnerEric GawiserCarlos Gómez-GuijarroYuchen GuoKurt HamblinTimothy S. HamiltonNimish P. HathiBenne W. HolwerdaMichaela HirschmannTaylor A. HutchisonAnne E. JaskotSaurabh W. JhaShardha JogeeStéphanie JuneauIntae JungSusan A. KassinAurélien Le BailGene C. K. LeungRay A. LucasBenjamin MagnelliKameswara Bharadwaj ManthaJasleen MatharuElizabeth J. McgrathDaniel H. McintoshEmiliano MerlinBahram MobasherJeffrey A. NewmanDavid C. NichollsViraj PandyaMarc RafelskiKaila RonaynePaola SantiniLise-Marie SeilléEkta A. ShahLu ShenRaymond C. SimonsGregory F. SnyderElizabeth R. StanwayAmber N. StraughnHarry I. TeplitzBrittany N. VanderhoofJesús Vega-FerreroWeichen WangBenjamin J. WeinerChristopher N. A. WillmerStijn WuytsJorge A. Zavala
• Organismes : Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Laboratoire d'Astrophysique de Marseille Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Observatoire astronomique de Strasbourg Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Marseille
• Publié dans The Astrophysical journal letters le 28/10/2020

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Résumé : We report the discovery of a candidate galaxy with a photo-z of z ~ 12 in the first epoch of the James Webb Space Telescope (JWST) Cosmic Evolution Early Release Science Survey. Following conservative selection criteria, we identify a source with a robust z _phot = ${11.8}_{-0.2}^{+0.3}$ (1σ uncertainty) with m _F200W = 27.3 and ≳7σ detections in five filters. The source is not detected at λ < 1.4 μm in deep imaging from both Hubble Space Telescope (HST) and JWST and has faint ~3σ detections in JWST F150W and HST F160W, which signal a Lyα break near the red edge of both filters, implying z ~ 12. This object (Maisie's Galaxy) exhibits F115W - F200W > 1.9 mag (2σ lower limit) with a blue continuum slope, resulting in 99.6% of the photo-z probability distribution function favoring z > 11. All data-quality images show no artifacts at the candidate's position, and independent analyses consistently find a strong preference for z > 11. Its colors are inconsistent with Galactic stars, and it is resolved (r _h = 340 ± 14 pc). Maisie's Galaxy has log M _*/M _⊙ ~ 8.5 and is highly star-forming (log sSFR ~ -8.2 yr^-1), with a blue rest-UV color (β ~ -2.5) indicating little dust, though not extremely low metallicity. While the presence of this source is in tension with most predictions, it agrees with empirical extrapolations assuming UV luminosity functions that smoothly decline with increasing redshift. Should follow-up spectroscopy validate this redshift, our universe was already aglow with galaxies less than 400 Myr after the Big Bang.

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Fichiers liés : Finkelstein_2022_ApJL_940_L55.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2021
• Auteurs : Lingxiao HeJohn MorleyGeetika AggarwalAndrew NguyenBruno VellasPhilipe de Souto BarretoSophie GuyonnetIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyYves RollandCéline CaillaudPierre-Jean OussetSherry WillisSylvie BellevilleBrigitte GilbertFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaMarie Noëlle-CuffiCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristel SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean‐pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalNicola Coley
• Organismes : Centre Hospitalier Universitaire de Toulouse Saint Louis University Saint Louis University Saint Louis University Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Equipe Vieillissement (CERPOP) Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Equipe Vieillissement (CERPOP)
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Neurofilament light chain (NfL) has been associated with cognitive status in multiple neurodegenerative conditions. Studies about plasma NfL and cognitive decline in older adults are still limited. 504 older adults (median age 75 years) who expressed memory complaints were selected from the Multidomain Alzheimer’s Preventive Trial (MAPT) and were classified as normal cognition (NC) or mild cognitive impairment (MCI). Cognitive functions were measured as mini mental state examination (MMSE) and composite cognitive score (CCS) over a 4-year period. Plasma NfL was measured at the first or the second year of the MAPT. Mixed-effects linear models were performed to evaluate cross-sectional and longitudinal associations. In the whole population, higher plasma NfL was cross-sectionally associated with lower cognitive functions (MMSE: β = − 0.007, 95% CI [− 0.013, − 0.001]; CCS: β = − 0.003, 95% CI [− 0.006, − 0.001]). In adults with MCI, but not NC, higher plasma NfL was associated with lower CCS at the cross-sectional level (β = − 0.003, 95% CI [− 0.005, − 0.0002]). The upper quartile NfL group further demonstrated more over time decline in CCS (β = − 0.07, 95% CI [− 0.12, − 0.01]) under the MCI status. Plasma NfL can be a promising biomarker of progressive cognition decline in older adults with MCI.

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Fichiers liés : s41598-021-91038-0.pdf

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