Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/07/2006
• Auteurs : François d'HautevilleMarianela FornerinoJean-Philippe Perrouty
• Organismes : Marchés, Organisations, Institutions et Stratégies d'Acteurs Institut national d’études supérieures agronomiques de Montpellier Centre d'études et de recherches appliquées à la gestion Marchés, Organisations, Institutions et Stratégies d'Acteurs Wine Intelligence

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Résumé : Disconfirmation of expectations is the mismatch between the expected and blind evaluation of a product (Anderson, 1973). From the consumer’s point of view, the hedonic evaluation of a product under full information (intrinsic and extrinsic) is considered as a measure of perceived quality. Generally, the perceived quality of a product differs according to tasting conditions (blind, or full information). Based on previous literature on food marketing we assume that the change of preference between blind and full conditions reflects the influence of extrinsic information (here, the region of origin). Two types of results can be expected from disconfirmation : “Assimilation” occurs when the final evaluation of the product changes in the direction of the expectation provided by the extrinsic cue, whereas “contrast” occurs when this change is contrary to the expectation. We experiment on five wines selected among regions with different reputation levels, and two groups of consumers, characterized by their level of expertise (trained/untrained students). Our experiments suggest that disconfirmation may be used to measure and interpret brand equity on a behavioural basis rather than just attitudinal.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/07/2006
• Auteurs : Albert HagègeJean-Pierre MarolleauJean-Thomas VilquinArmelle AlhéritièreSéverine PeyrardDenis DubocEric AbergelEmmanuel MessasElie MousseauxKetty SchwartzMichel DesnosPhilippe Menasché
• Organismes : Université Paris Descartes - Paris 5 Therapie Cellulaire en Pathologie Cardio-Vasculaire Hôpital Européen Georges Pompidou [APHP] Hopital Saint-Louis [AP-HP] Physiopathologie et thérapie du muscle strié Université Paris Descartes - Paris 5 Institut de Myologie Hôpital Cochin [AP-HP] Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5 Physiopathologie et thérapie du muscle strié Hopital Saint-Louis [AP-HP] Université Paris Descartes - Paris 5 Université Paris Descartes - Paris 5
• Publié dans Circulation le 29/10/2020

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Résumé : Background— Skeletal myoblast (SM) transplantation (Tx) in a post-myocardial infarction (MI) scar experimentally improves left ventricular (LV) ejection fraction (EF). Short-term follow-up (FU) studies have suggested that a similar benefit could clinically occur despite an increased risk of LV arrhythmias. Methods and Results— We report the long-term FU of the first worldwide cohort of grafted patients (n =9, 61.8±11.6 years, previous MI, EF ≤35%) operated on (autologous SM Tx and bypass surgery) in 2000 to 2001 and evaluated before Tx, at 1 month (M1) and at a median FU of 52 (18 to 58) months after Tx (37 patient-years). NYHA class improved from 2.5±0.5 to 1.8±0.4 at M1 ( P =0.004 versus baseline) and 1.7±0.5 at FU ( P =not significant versus M1; P =0.0007 versus baseline). EF increased from 24.3±4% to 31±4.1% at M1 (+28%, P =0.001 versus baseline) and remained stable thereafter (28.7±8.1%, +18% versus baseline). There were 5 hospitalizations for heart failure in 3 patients at 28.6±9.9 months, allowing implant in 2 patients with a resynchronization pacemaker. An automatic cardiac defibrillator (ACD) was implanted in 5 patients for nonsustained (n =1) or sustained (n =4) ventricular tachycardia at 12.2±18.6 (1 to 45) months. Despite a beta-blocker/amiodarone combination therapy, there were 14 appropriate shocks for 3 arrhythmic storms in 3 patients at 6, 7, and 18 months after ACD implantation. Conclusions— In this cohort of severe heart failure patients both clinical status and EF stably improve over time with a strikingly low incidence of hospitalizations for heart failure (0.13/patient-years) and the arrhythmic risk can be controlled by medical therapy and/or on-request ACD implantation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Philippe Berthet RambaudPascal PerrotinFabien DelhommeMichel MommessinJean Pierre MouginJean TonelloJacky Mazars
• Organismes : Laboratoire régional des ponts et chaussées de Lyon Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Laboratoire optimisation de la conception et ingénierie de l'environnement Bureau d'études Tonello I.C Laboratoire Sols, Solides, Structures
• Publié dans BLPC - Bulletin des Laboratoires des Ponts et Chaussées le 08/06/2017

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Résumé : Des expérimentations ont été récemment réalisées en France sur un nouveau type de protection contre les chutes de blocs, caractérisé par une dalle sans couche amortissante simplement posée sur sa structure porteuse par l'intermédiaire de fusibles métalliques. L'étude directe des mesures, effectuées sur maquette à l'échelle 1/3, permet de comprendre les principaux phénomènes mécaniques en jeu pendant les phases de l'impact. Le poinçonnement et la percussion sont analysés pour quantifier la force d'impact. Une modélisation tri-dimensionnelle de la structure et de ses appuis est également proposée. Cette analyse numérique introduit la sollicitation comme en situation réelle et est fondée sur une approche par éléments finis couplée à une loi de comportement, qui permet une représentation réaliste du comportement et de l'endommagement du béton sous chargements dynamiques. Ces travaux devraient conduire à la mise au point de règles de conception et de dimensionnement performantes utilisables par les bureaux d'étude.

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Fichiers liés : aer000001756.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Jean-François PongeStéphanie TopoliantzSylvain BallofJean-Pierre RossiPatrick LavelleJean-Marie BetschPhilippe Gaucher
• Organismes : Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers Fonctionnement, évolution et mécanismes régulateurs des écosystèmes forestiers Direction territoriale Guyane Biodiversité, Gènes et Ecosystèmes Biodiversité et fonctionnement des sols Réseaux trophiques du sol Mission d'Etude pour la Création du Parc de la Guyane
• Publié dans Soil Biology and Biochemistry le 22/10/2020

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Résumé : It is now attested that a large part of the Amazonian rain forest has been cultivated during Pre-Colombian times, using charcoal as an amendment. The incorporation of charcoal to the soil is a starting point for the formation of fertile Amazonian Dark Earths, still selected by Indian people for shifting cultivation. We showed that finely separated charcoal was commonly incorporated in the topsoil by Pontoscolex corethrurus, a tropical earthworm which thrives after burning and clearing of the rain forest, and that this natural process could be used to improve tropical soil fertility. Our paper is a contribution to the present debate about (i) the origin of black carbon in fertile Dark Earths, (ii) the detrimental vs favourable role of Pontoscolex corethrurus in tropical agriculture, (iii) natural processes which might be used to increase tropical soil fertility.

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Fichiers liés : Article_SBB.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Barbara SeliskoHélène DutartreJean-Claude GuillemotClaire DebarnotDelphine BenarrochAlexander KhromykhPhilippe DesprèsMarie-Pierre EgloffBruno Canard
• Organismes : Architecture et fonction des macromolécules biologiques Oncogenèse rétrovirale – Retroviral Oncogenesis [CIRI] Laboratoire de biochimie des protéines Centre de recherche en neurobiologie - neurophysiologie de Marseille Laboratoire de Biologie Moléculaire de la Cellule Département de radio-oncologie and Centre de recherche du CHU de Québec Architecture et fonction des macromolécules biologiques
• Publié dans Virology le 24/10/2020

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Résumé : Flavivirus protein NS5 harbors the RNA-dependent RNA polymerase (RdRp) activity. In contrast to the RdRps of hepaci- and pestiviruses, which belong to the same family of Flaviviridae, NS5 carries two activities, a methyltransferase (MTase) and a RdRp. RdRp domains of Dengue virus (DV) and West Nile virus (WNV) NS5 were purified in high yield relative to full-length NS5 and showed full RdRp activity. Steady-state enzymatic parameters were determined on homopolymeric template poly(rC). The presence of the MTase domain does not affect the RdRp activity. Flavivirus RdRp domains might bear more than one GTP binding site displaying positive cooperativity. The kinetics of RNA synthesis by four Flaviviridae RdRps were compared. In comparison to Hepatitis C RdRp, DV and WNV as well as Bovine Viral Diarrhea virus RdRps show less rate limitation by early steps of short-product formation. This suggests that they display a higher conformational flexibility upon the transition from initiation to elongation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Emmanuel GarcionAlf LamprechtBéatrice HeurtaultArchibald PaillardAnne Aubert-PouesselBenoît DenizotPhilippe MeneiJean-Pierre Benoît
• Organismes : Ingénierie de la vectorisation particulaire Ingénierie de la vectorisation particulaire Laboratoire d'ingiénerie pharmaceutique Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Ingénierie de la vectorisation particulaire Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Ingénierie de la vectorisation particulaire Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Service de neurochirurgie [CHU Angers] Ingénierie de la vectorisation particulaire Laboratoire de thermodynamique et physico-chimie métallurgiques
• Publié dans Molecular Cancer Therapeutics le 29/10/2020

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Résumé : By focusing on rat glioma, we elucidated whether new lipid nanocapsules (LNC) were able to improve anticancer hydrophobic drug bioavailability while also overcoming multidrug resistance. Blank LNCs and LNCs loaded with the antineoplastic agent paclitaxel were formulated by an emulsion inversion phase process. Expression of efflux pumps by rat glioma cells was assessed by reverse transcription-PCR, Western blot, and immunohistochemistry, and their activity was followed using the tracer (99)Tc(m)-methoxyisobutylisonitrile. Modalities of LNC action were addressed by using confocal microscopy detection of fluorescently labeled LNCs, fluorescence-activated cell sorting, high-performance liquid chromatography measurement of paclitaxel release, and analysis of tumor cell growth. This revealed an interaction between LNCs and efflux pumps that resulted in an inhibition of multidrug resistance in glioma cells, both in culture and in cell implants in animals. LNCs were able to target the intracellular compartment of glioma cells, a mechanism that was abrogated by using intracellular cholesterol inhibitors but not by clathrin-coated pit or caveolae uptake inhibitors. This result can be correlated to the LNC inhibitory effects on efflux pump activity that is itself known to be stimulated by intracellular cholesterol. In parallel, we showed that paclitaxel-loaded LNCs were active reservoirs from which paclitaxel could be released. Finally, we established that paclitaxel-loaded LNCs were more efficient than the commercially available paclitaxel formulation (Taxol) for clinical use, thus reducing tumor expansion in vitro and in vivo. Considering the physiologically compatible nature of LNC excipients, these data may represent an important step towards the development of new clinical therapeutic strategies against cancers.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/07/2006
• Auteurs : Alexandre SkrzypczackPierre SiohanJean-Philippe Javaudin
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/07/2006
• Auteurs : Cornelis van LeeuwenJean-Pascal GoutoulyChloé AzaïsAnne-Marie Costa FerreiraElisa MargueritJean-Philippe RobyXavier ChonéChristian GermainSaeid HomayouniJean-Pierre Gaudillère
• Organismes : Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Ecophysiologie et Génomique Fonctionnelle de la Vigne Laboratoire de l'intégration, du matériau au système Laboratoire de l'intégration, du matériau au système Ecophysiologie et Génomique Fonctionnelle de la Vigne

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Résumé : Vine water status was measured on 96 blocks of three vines inside a vineyard plot of 0,28 ha during three years: 2003, 2004 and 2005. Three physiological indicators were implemented: stem water potential, carbon isotope discrimination measured on grape sugars at ripeness (δ13C) and canopy temperature measured by high resolution remote sensing. For stem water potential, measurements were taken on every single vine of each block. The objectives of this study were to assess (i) the spatial distribution of vine water status inside a vineyard plot, (ii) the temporal stability of this distribution from one date to another in the same year and (iii) the temporal stability of this distribution from one year to another. The three physiological indicators provided accurate data of vine water status, as was shown by high correlation coefficients between stem water potential values and canopy temperature, as well as between stem water potential and δ13C. Vine water status maps obtained with either stem water potential data or δ13C data showed similar patterns of spots that were more or less affected by water deficit stress, in relation to local soil water holding capacity. Stem water potential was measured in September 2004 on two days in a row, one cloudy day and the next day with higher temperatures and clear conditions. Stem water potential values were highly correlated between these two days, which confirms the fact that stem water potential is mainly influenced by soil water status. However, stem water potential values were in average 0.08 MPa higher on the cloudy day, which shows a measurable but limited influence of evaporative demand on absolute stem water potential values. Both stem water potential values and δ13C data were well correlated from one year to another, which shows a stability of spatial distribution of vine water status inside the plot. This can be explained by the fact that soil water holding capacity is invariable from one year to another. Surprisingly, stem water potential values measured at the same time between vine 1, vine 2 and vine 3 of each block were not very well correlated, although the soil can be considered homogeneous inside a block (3 m2). This observation shows high variability in vine to vine water status, in relation to individual vine rooting depth and canopy size. Consequently, replicates on several adjacent vines have to be averaged out to obtain accurate vine water status data for each block.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2006
• Auteurs : Céline ChizalletGuylène CostentinHélène Lauron-PernotJean Marc KrafftPhilippe BazinJacques SausseyFrançoise DelbecqPhilippe SautetMichel Che
• Organismes : Laboratoire de Réactivité de Surface Laboratoire de Réactivité de Surface Laboratoire de Réactivité de Surface Laboratoire de Réactivité de Surface Laboratoire catalyse et spectrochimie Laboratoire catalyse et spectrochimie Laboratoire de Chimie - UMR5182 Laboratoire de Chimie - UMR5182 Laboratoire de Réactivité de Surface
• Publié dans Oil & Gas Science and Technology - Revue d'IFP Energies nouvelles le 26/10/2020

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Résumé : Clean (i.e., carbonate- and hydroxyl-free) and hydroxylated MgO surfaces of various morphologies were used to study the correlation between thermodynamic Brønsted basicity (evaluated by the deprotonation of methanol and propyne followed by FTIR) and basic reactivity (evaluated by the conversion of 2-methyl-but-3-yn-2-ol (MBOH)). A correlation is evidenced for clean surfaces, but for hydroxylated surfaces, OH groups, though weak Brønsted bases, are much more active than oxide O2- ions. Some of the hydroxyl groups whose VOH infra-red stretching band is included in the narrow high-frequency OH band were shown to be responsible for such activity. In order to identify them, the irregularities of surfaces involving low coordination (LC) ions were modeled by DFT calculations (mono- and di-atomic steps for 4C ions, corners, kinks and divacancies for 3C ions). All of them dissociate water: except for kinks and divancancies where the OH formed can be considered as isolated, in all the other cases, OH groups are H-bonded. The í OH infra-red frequencies obtained by calculations are consistent with the experimental spectrum which exhibits two domains: the broad low-frequency (${\rm V}_{\rm OH} < 3700$) domain is assigned to H-bond donor OH groups (O3CH, O4CH and O5CH), whereas the high-frequency narrow band (${\rm V}_{\rm OH} > 3700$ cm-1) corresponds to isolated OH (O2CH, O3CH and O4CH in kinks and divacancies) and H-bond acceptor OH groups (O1CH and O2CH). The latter are inferred to be implied in basic reactivity of hydroxylated surfaces toward MBOH.

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Fichiers liés : ogst06009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/06/2006
• Auteurs : Pierre-Yves LéoJean Philippe
• Organismes : Centre d'Études et de Recherche en Gestion d'Aix-Marseille SBM offshore
• Publié dans Belgeo : Revue Belge de Géographie le 30/10/2020

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Résumé : Cet article présente les résultats d’une recherche consacrée à l’industrie des services de restauration en France, qui se trouve confrontée à des modifications des habitudes de consommation ainsi qu’à une concurrence considérable. La croissance soutenue des métropoles est un facteur d’une importance capitale pour cette activité car elle augmente la demande de repas de qualité à l’extérieur du domicile. Afin de maintenir un taux de croissance rapide, les leaders étendent leurs chaînes de restaurants tout spécialement dans les pôles périphériques situés dans les faubourgs des grandes agglomérations. En même temps, certains d’entre eux adoptent les modèles et les concepts de leurs concurrents. Dans ce contexte, l’implantation d’un site apparaît comme un moyen puissant de protection de leur marché local et d’instauration de barrières à l’entrée : le consommateur n’accepte que de courts temps de parcours de et vers les restaurants. Cet article se fonde sur une enquête menée dans trois villes du sud de la France et sur l’analyse des ensembles de considération.

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Fichiers liés : belgeo-11102.pdf

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