Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 11/12/2007
• Auteurs : Jean-Philippe RegnauxKaveh SaremiJon MarehbianBernard BusselBruce H Dobkin
• Organismes : Department of Neurology Physiologie et physiopathologie de la motricité chez l'homme AP-HP - Hôpital Raymond Poincaré
• Publié dans Journal of Neurologic Rehabilitation le 27/10/2020

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Résumé : OBJECTIVE: . Two commercial robotic devices, the Gait Trainer (GT) and the Lokomat (LOKO), assist task-oriented practice of walking. The gait patterns induced by these motor-driven devices have not been characterized and compared. METHODS: . A healthy participant chose the most comfortable gait pattern on each device and for treadmill (TM) walking at 1, 2 (maximum for the GT), and 3 km/h and over ground at similar speeds. A system of accelerometers on the thighs and feet allowed the calculation of spatiotemporal features and accelerations during the gait cycle. RESULTS: . At the 1 and 2 km/h speed settings, single-limb stance times were prolonged on the devices compared with overground walking. Differences on the LOKO were decreased by adjusting the hip and knee angles and step length. At the 3 km/h setting, the LOKO approximated the participant's overground parameters. Irregular accelerations and decelerations from toe-off to heel contact were induced by the devices, especially at slower speeds. CONCLUSIONS: . The LOKO and GT impose mechanical constraints that may alter leg accelerations-decelerations during stance and swing phases, as well as stance duration, especially at their slower speed settings, that are not found during TM and overground walking. The potential impact of these perturbations on training to improve gait needs further study.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/12/2007
• Auteurs : Xavier ChardonCyrille RigolotChristine BaratteAlain-Hervé Le GallS. EspagnolRoger Martin-ClouaireJean-Pierre RellierChristelle RaisonJean-Claude PoupaPhilippe Faverdin
• Organismes : Production du lait Institut de l'élevage Systèmes d'Elevage, Nutrition Animale et Humaine Institut du Porc Production du lait Institut de l'élevage Institut du Porc Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) Unité de Biométrie et Intelligence Artificielle (ancêtre de MIAT) Institut de l'élevage Unité de recherche d'Économie et Sociologie Rurales Production du lait

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2007
• Auteurs : Karine Le GuenHélène MauryJean-Michel AndréPhilippe JonnardAurélie HardouinFranck DelmotteMarie-Françoise Ravet-Krill
• Organismes : Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop Laboratoire Charles Fabry de l'Institut d'Optique / Scop
• Publié dans Applied Physics Letters le 01/11/2020

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Résumé : The use of Cr/Sc multilayer interferential mirrors (MIMs) in optical systems such as x-ray microscopes or telescopes have been reported for the water window (between C K- and O K-absorption edges). However, their possibilities in spectroscopic application have never been described in the literature. The purpose of the paper is to report for the first time on the performances of Cr/Sc MIMs as Bragg dispersive devices for the analysis in wavelength dispersive spectrometry of samples containing N or Sc atoms. The possibility to distinguish the chemical state of the emitting N or Sc atoms is evidenced by using Johan-type and double-crystal spectrometers.

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Fichiers liés : 00575878.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Jean-René PallandreEmilie BrillardGilles CréhangeAmandine RadlovicJean-Paul Remy-MartinPhilippe SaasPierre-Simon RohrlichXavier B. PivotXiang LingPierre TiberghienChristophe Borg
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service de Radiothérapie [CHRU Besançon] Service de Radiothérapie [CHRU Besançon] Service de Radiothérapie [CHRU Besançon] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'Oncologie Médicale [CHRU Besançon] Section of Molecular Hematology and Therapy Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'Oncologie Médicale [CHRU Besançon]
• Publié dans Journal of Immunology le 27/10/2020

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Résumé : Immunological tolerance is maintained by specialized subsets of T cells including CD4(+)CD25(+)FOXP3(+) regulatory cells (Treg). Previous studies established that Treg thymic differentiation or peripheral conversion depend on CD28 and Lck signaling. Moreover, foxp3 gene transfer in murine CD4(+)CD25(-) T lymphocytes results in the acquisition of suppressive functions. However, molecular pathways leading to FOXP3 expression remain to be described. In this study, we investigated the molecular events driving FOXP3 expression. We demonstrated that CD28 activation in CD4(+)CD25(-) T lymphocytes leads to STAT3 Tyr(705) phosphorylation in an Lck-dependent manner. STAT3 neutralization during naive peripheral CD4(+)CD25(-) T cell conversion into Treg through costimulation with TCR/CD28 and TGF-beta1, decreased FOXP3 expression, prevented the acquisition of suppressive functions and restored the ability of the converted lymphocytes to produce IL-2 and IFN-gamma. Furthermore, we observed that STAT3 ablation using small interfering RNA strategies inhibited FOXP3 expression and suppressive functions among naturally differentiated CD4(+)CD25(+) T lymphocytes, suggesting a direct role of STAT3 in Treg phenotype and function maintenance. CD4(+)CD25(+) T lymphocytes transduced with specific STAT3 small interfering RNA were devoid of suppressive functions and failed to control the occurrence of acute graft-vs-host disease. Finally, STAT3 inhibition in CD4(+) lymphocytes enhanced the anti-tumor immunity conferred by a lymphocyte adoptive transfer. In summary, our findings determine that STAT3 is critical in the molecular pathway required for FOXP3 expression. STAT3 modulation should be taken into account when assessing how regulatory T cells contribute to inflammatory diseases and tumor immunosurveillance.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Pierre BorgnatPatrice AbryGuillaume DewaeleAntoine ScherrerNicolas LarrieuPhilippe OwezarskiYann LabitLaurent GallonJulien Aussibal
• Organismes : Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de l'Informatique du Parallélisme Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour Laboratoire Informatique de l'Université de Pau et des Pays de l'Adour
• Publié dans Annals of Telecommunications - annales des télécommunications le 22/10/2020

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Résumé : Being now a mainstream communication, Internet is subject to many kinds of anomalies (failures, flash-crowds, attacks). In order to compare the statistics of normal traffic with traffic with anomalies, we collect both regular and anomalous traffic. The traffic is collected on the RENATER network by the METROSEC project and we produce both Denial of Service (DoS) attacks with real attack softwares (TFN2K, TRIN00) aimed at various services (ICMP, SYN, UDP, TCP), and flash-crowd anomalies. We propose a multiresolution, non-Gaussian model with long memory and the corresponding estimators. It models, jointly at all aggregation levels, normal traffic, and also traffic containing anomalies. We show that the model enables to detect the anomalies in the traffic and distinguish between flash-crowd and DoS types of anomaly.

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Fichiers liés : 07_annales_telecoms_borgnat_draft.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Estelle Jumas-BilakJean-Philippe CarlierHélène Jean-PierreDiane CitronKathryn BernardAudrey DamayBernard GayCorinne TeyssierJosiane CamposH. Marchandin
• Organismes : Laboratoire universitaire d'antibiologie Laboratoire de Bactériologie Institut de Recherche en Infectiologie de Montpellier Department of Geology and Geophysics Facultat de Fisica, Departament Universitari d'Optica Laboratoire universitaire d'antibiologie Laboratoire de Bactériologie
• Publié dans International Journal of Systematic and Evolutionary Microbiology le 31/10/2020

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Résumé : Six clinical isolates of a hitherto unknown, strictly anaerobic, Gram-negative rod showing fastidious growth were subjected to a polyphasic taxonomic study, including phenotypic, genomic and phylogenetic feature analyses. 16S rRNA gene sequenced-based phylogeny revealed that the novel strains represent a homogeneous group distant from any recognized species in the candidate phylum 'Synergistetes'. The novel isolates were most closely related to species of the genus Dethiosulfovibrio, with 88.2-88.7 % 16S rRNA gene sequence similarity. Large-scale chromosome structure and DNA G+C content also differentiated the novel strains from members of the genus Dethiosulfovibrio. The novel strains were asaccharolytic. Major metabolic end products in trypticase/glucose/yeast extract broth were acetic, lactic, succinic and isovaleric acids and the major cellular fatty acids iso-C(15 : 0) and C(16 : 0). Based on the data presented here, a new genus, Jonquetella gen. nov., is proposed with one novel species, Jonquetella anthropi sp. nov. J. anthropi is the first characterized species of the candidate phylum 'Synergistetes' that includes human isolates. The G+C content of the DNA of the type strain of J. anthropi ADV 126(T) (=AIP 136.05(T)=CIP 109408(T)=CCUG 53819(T)) is 59.4 mol%.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Philippe FontaineMarie Claude FaureFrançois MullerMathieu PoujadeJean-Sébastien MichaFrançois RieutordMichel Goldmann
• Organismes : Institut des Nanosciences de Paris Institut des Nanosciences de Paris Service de Physique des Matériaux et Microstructures Institut Nanosciences et Cryogénie Institut des Nanosciences de Paris
• Publié dans Langmuir le 27/10/2020

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Résumé : We studied at the molecular level the interaction between neutral detergent Triton X-100 aqueous solution and a phospholipid Langmuir monolayer deposited on top using surface pressure measurement and grazing incidence X-ray diffraction (GIXD). Macroscopically, the detergent-phospholipid system follows the Gibbs law. However, GIXD shows that the detergent and the phospholipid segregate at the interface. The molecular organization of pure phospholipid domains is imposed by the detergent through surface pressure. Compression and expansion of the surface monolayer system in its final state reveal the stability of the phospholipids domains against dissolution by the detergent in the subphase, even above the detergent cmc. This resistance to dissolution is suppressed by an expansion of the monolayer.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Sebastien FauChrystelle PoBrigitte GilletStephane SizonenkoJean MarianiPhilippe MericChristiane Charriaut-Marlangue
• Organismes : Neurobiologie des processus adaptatifs Institut de Chimie des Substances Naturelles Institut de Chimie des Substances Naturelles Neurobiologie des processus adaptatifs Institut de Chimie des Substances Naturelles Neurobiologie des processus adaptatifs
• Publié dans Experimental Neurology le 23/10/2020

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Résumé : Cerebral hypoxia-ischemia is an important cause of brain injury in the newborn infant. Our purpose was to study magnetic resonance (MR) imaging changes in P7 rat brains submitted to permanent or reversible ischemia. Ischemia was induced by permanent electro-cauterization of the middle cerebral artery combined with a permanent or a transient (50 min) common carotid artery occlusion. The early events during ischemia and reperfusion were investigated by T2-weighted images (T2WI) at 1 and 3 h and by serial diffusion-weighted images (DWI) during 3 h in a 7 T magnet with a standard weighted diffusion sequence (b=1282.04 s mm(-2)) and a SEMS sequence. Within the first hour after MCA occlusion, the T2WI areas of contrast enhancement increased to a mean volume of 12.9+/-6.4%, a steady state still detected at 3 h after the ischemic onset (10.5+/-2.5%). Contrast enhancement in DWI increased as soon as 15 min of ischemia in all animals up to 50 min after CCA occlusion. In permanent ischemia, DWI abnormalities volume then increased more slowly from 50 min to 3 h after CCA occlusion (+25%, n=5). In reversible ischemia, the DWI abnormalities volume either moderately decreased and reached a plateau (-8.4%, n=4) or dramatically decreased (-53.0%, n=3). Both T2WI and DWI evidenced a "patchy" pattern of recovery as also shown on cresyl violet-stained sections. In contrast to the adult, early ischemic injury in P7 rat brains is detected as an increase in hyper-intensities both in T2WI and DWI. Our data indicate that reperfusion is able to block edema evolution after neonatal stroke and that early T2WI and more accurately DWI allow to distinguish between different patterns of injury in reversible ischemia.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Jean-Philippe LachauxPierre FonluptPhilippe KahaneLorella MinottiDominique M. HoffmannOlivier BertrandMonica Baciu
• Organismes : Équipe Dynamique Cérébrale et Cognition - Brain Dynamics and Cognition Team Équipe Dynamique Cérébrale et Cognition - Brain Dynamics and Cognition Team Département de neurologie Département de neurologie Neurosciences précliniques Équipe Dynamique Cérébrale et Cognition - Brain Dynamics and Cognition Team Laboratoire de Psychologie et NeuroCognition
• Publié dans Human Brain Mapping le 26/10/2020

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Résumé : Cognitive neuroscience relies on two sets of techniques to map the neural networks underlying cognition in humans: recordings of either regional metabolic changes (fMRI or PET) or fluctuations in the neural electromagnetic fields (EEG and MEG). Despite major advances in the last few years, an explicit linkage between the two is still missing and the neuroimaging community faces two complementary but unrelated sets of functional descriptions of the human brain. Such an explicit framework, linking the two approaches in potentially complex cognitive tasks and in a variety of brain regions would permit to combine them into fine spatio-temporally-grained human brain mapping procedures. We combined fMRI and intra-cranial EEG recordings of the same epileptic patients during a semantic decision task and found a close spatial correspondence between regions of fMRI activations and recording sites showing EEG energy modulations in the gamma range (>40 Hz). Our findings further support previous findings that gamma band modulations co-localize with BOLD variations and also indicate that fMRI may be used as a constraint to improve source reconstruction of gamma band EEG responses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2007
• Auteurs : Éléonore WelcommePhilippe WalterPierre BleuetJean-Louis HodeauEric DooryheePauline MartinettoMichel Menu
• Organismes : Centre de recherche et de restauration des musées de France Centre de recherche et de restauration des musées de France European Synchrotron Radiation Facility Matériaux, Rayonnements, Structure Matériaux, Rayonnements, Structure Matériaux, Rayonnements, Structure Centre de recherche et de restauration des musées de France
• Publié dans Applied physics. A, Materials science & processing le 28/10/2020

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Résumé : The lead white pigment was used and synthesised for cosmetic and artistic purposes since antiquity. Ancient texts describe their recipes, their preparation processes or their location of production. In this study, we describe the results obtained on several paint samples from Matthias Grünewald, a major painter at the beginning of the German Renaissance. Thanks to X-ray diffraction analyses using synchrotron radiation, it is possible to relate the composition of the paint samples with the master's ancient recipes. Different approaches were used, in reflection and transmission modes, directly on minute samples or on paint cross-sections embedded in resin. The characterisation of the lead white pigments reveals variations in terms of composition, graininess and proportion of mineral phases. The present work shows the presence of lead white as differentiable main composition groups, which could be characteristic of a period, a know-how or a geographical origin. In this way, we aim at understanding the choices and the trading of pigments to realize paintings during Northern European Renaissance.

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