Philippe JEAN-PIERRE

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2008
• Auteurs : Philippe DebaekeMarie-Sophie PetitMichel BertrandPierre MischlerNicolas Munier-JolainJean-Marie NolotRaymond ReauNathalie Verjux
• Organismes : Agrosystèmes Cultivés et Herbagers Chambre d'Agriculture de la Côte d'Or FLAveur, VIsion et Comportement du consommateur Agronomie ARVALIS - Institut du végétal [Paris]

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Résumé : Ce chapitre fait le point sur les méthodes d’évaluation des systèmes de culture en s'appuyant sur des expériences récentes menées dans différents organismes de recherche et de développement, que ce soit en station expérimentale ou en réseau de parcelles agricoles. Dans un premier temps nous décrivons la démarche d'évaluation partagée, puis nous soulignons les difficultés rencontrées, les solutions apportées et les verrous méthodologiques à lever, liés au caractère pluriannuel et multicritère de cette évaluations

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : P. FerrandoM. ArnaudU. BrielE. CavazuttiR. ClédassouJ.L. CounilF. FioreP. GiommiA. GoldwurmO. LamarlePhilippe LaurentF. LebrunG. MalagutiS. MereghettiG. MicelaG. PareschiM. PiermariaJean-Pierre RoquesG. Tagliaferri
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie Département d'Astrophysique (ex SAP) Centre National d'Études Spatiales [Toulouse] Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie APC - Astrophysique des Hautes Energies Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie INAF - Osservatorio Astronomico di Palermo Centre d'étude spatiale des rayonnements
• Publié dans Memorie della Societa astronomica italiana le 29/10/2020

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Résumé : Simbol-X is a hard X-ray mission, operating in the ˜ 0.5-80 keV range, proposed as a collaboration between the French and Italian space agencies with participation of German laboratories for a launch in 2013. Relying on two spacecrafts in a formation flying configuration, Simbol-X uses for the first time a 20 m focal length X-ray mirror to focus X-rays with energy above 10 keV, resulting in over two orders of magnitude improvement in angular resolution and sensitivity in the hard X-ray range with respect to non-focusing techniques. The Simbol-X revolutionary instrumental capabilities will allow to elucidate outstanding questions in high energy astrophysics such as those related to black-holes accretion physics and census, and to particle acceleration mechanisms. Simbol-X has been selected for a phase A study which is jointly conducted by CNES and ASI. We give in this paper a general overview of the mission, as consolidated close to the end of the phase A.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2008
• Auteurs : Jean-Pierre AllegretPhilippe Dulbecco
• Organismes : Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne Centre d'Études et de Recherches sur le Développement International

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Fichiers liés : Allegret_Dulbecco SIX.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Gurvan MagadurJean‐sébastien LauretValérie Alain-RizzoChristophe VoisinPhilippe RoussignolEmmanuelle DeleporteJacques A. Delaire
• Organismes : Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires
• Publié dans ChemPhysChem le 29/10/2020

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Résumé : Tailoring the properties of carbon nanotubes by functionalizing their side-wall is one of the key challenges towards the realization of carbon nanotube-based optoelectronic devices. This technique aims at combining the remarkable transport properties of the tube with the versatility of the optical properties of organic molecules. Herein, we achieve p-stacking functionalization of nanotubes with hydrosoluble porphyrins.

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Fichiers liés : chemphyschemversionHAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : N. StremsdoerferAlain BlanchiJean-Pierre BronowickiFrançois-Xavier Caroli-BoscXavier CausseF. MasskouriPhilippe RougierLaurent BedenneMichel DoffoëlF. BonnetainOlivier BouchéD. VetterArmand AbergelS. FrattéJean-Didier Grangé
• Organismes : Service d'Hépato-gastro-entérologie [CHRU Nancy] Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Centre Hospitalier Universitaire d'Orléans AP-HP - Hôpital Européen Georges Pompidou Lipides - Nutrition - Cancer (U866) Service d'hépato-gastroentérologie Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Université de Reims Champagne-Ardenne Département de Radiologie Image Science for Interventional Techniques Centre Hospitalier de Belfort-Montbéliard AP-HP - Hôpital Tenon
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé :

The FFCD 9402 multicentre phase III trial was designed to compare the effects of the combination of Transarterial Lipiodol Chemoembolisation (TACE) and tamoxifen with tamoxifen alone on overall survival and quality of life in the palliative treatment of hepatocellular carcinoma with cirrhosis. From 1995 to 2002, 138 patients were randomised between the two groups. One hundred and twenty three patients were eligible including 61 in the Tamoxifen group and 62 in the TACE group. Baseline characteristics were similar: Child-Pugh class A: 70%, alcoholic cirrhosis: 76%, Okuda stage I: 71%, multinodular tumour: 70% and segmental portal vein thrombosis: 10%. At 2 years, the overall survival was 22% and 25% in the Tamoxifen and TACE groups (P = .68), respectively. Multivariate analysis identified four independent prognostic factors for survival: α-fetoprotein (AFP) > 400 ng/mL (P = .008), abdominal pain (P = .011), hepatomegaly (P = .023) and Child-Pugh score (P = .032). The Spitzer Index level assessing the quality of life during follow-up did not differ between the two groups (P = .70). Amongst patients with stage Okuda I, the 2-year overall survival was 28% in the Tamoxifen group and 32% in the TACE group (P = .58). In this subgroup, two prognostic factors were statistically significant for survival: AFP > 400 ng/mL (P = .004) and Spitzer Index (P = .013) as shown by multivariable analysis.In conclusion, this study suggests that TACE improves neither the survival nor the quality of life in patients with HCC and cirrhosis.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Olivier HermineOlivier LortholaryPhillip S LeventhalAdeline CatteauFrédérique SoppelsaCedric BaudeAnnick Cohen-AkenineFabienne PalmériniKatia HanssensYing YangHagay SobolSylvie FraytagDavid GhezFelipe SuarezStéphane BaretePhilippe CasassusBeatrice SansMichel ArockJean Pierre KinetPatrice DubreuilAlain Moussy
• Organismes : Cytokines, hématopoïèse et réponse immune Service d'immuno-hématologie pédiatrique [CHU Necker] Cancérologie AFIRM network AFIRM network Cytokines, hématopoïèse et réponse immune AFIRM network AFIRM network Université de la Méditerranée - Aix-Marseille 2 Cancérologie Institut de cancérologie et d'immunologie de Marseille AFIRM network Université de la Méditerranée - Aix-Marseille 2 Cancérologie Institut de cancérologie et d'immunologie de Marseille Institut de cancérologie et d'immunologie de Marseille Service d'Oncologie Génétique, de Prévention et Dépistage Cytokines, hématopoïèse et réponse immune Service d'immuno-hématologie pédiatrique [CHU Necker] Service d'immuno-hématologie pédiatrique [CHU Necker] AP-HP - Hôpital Tenon Service d'hématologie clinique [Avicenne] Service Dermatologie [CHU Toulouse] Laboratoire de Biologie et de Pharmacologie Appliquée Université de la Méditerranée - Aix-Marseille 2 Cancérologie Institut de cancérologie et d'immunologie de Marseille AFIRM network
• Publié dans PLoS ONE le 25/10/2020

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Résumé : BACKGROUND: Indolent forms of mastocytosis account for more than 90% of all cases, but the types and type and severity of symptoms and their impact on the quality of life have not been well studied. We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis. METHODOLOGY/PRINCIPAL FINDINGS: In 2004, 363 mastocytosis patients and 90 controls in France were asked to rate to their overall disability (OPA score) and the severity of 38 individual symptoms. The latter was used to calculate a composite score (AFIRMM score). Of the 363 respondents, 262 were part of an ongoing pathophysiological study so that the following data were available: World Health Organization classification, standard measures of physical and psychological disability, existence of the D816V KIT mutation, and serum tryptase level. The mean OPA and AFIRMM scores and the standard measures of disability indicated that most mastocytosis patients suffer from disabilities due to the disease. Surprisingly, the patient's measurable and perceived disabilities did not differ according to disease classification or presence or absence of the D816V KIT mutation or an elevated (> or = 20 ng/mL) serum tryptase level. Also, 32 of the 38 AFIRMM symptoms were more common in patients than controls, but there were not substantial differences according to disease classification, presence of the D816V mutation, or the serum tryptase level. CONCLUSIONS: On the basis of these results and for the purposes of treatment, we propose that mastocytosis be first classified as aggressive or indolent and that indolent mastocytosis then be categorized according to the severity of patients' perceived symptoms and their impact on the quality of life. In addition, it appears that mastocytosis patients suffer from more symptoms and greater disability than previously thought, that mastocytosis may therefore be under-diagnosed, and that the symptoms of the indolent forms of mastocytosis might be due more to systemic release of mediators than mast cell burden.

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Fichiers liés : 2008plosOneHermine.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Philippe DebaekeJean-Pierre Amigues
• Organismes : AGroécologie, Innovations, teRritoires Economie des Ressources Naturelles
• Publié dans La Houille Blanche - Revue internationale de l'eau le 26/10/2020

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Résumé : Since 2003, Center-West and South-West of France are regularly affected by drought events (either edaphic or hydrologic) with dramatic consequences on yield, irrigation water use and farmer’s net income. To cope with drought and irrigation water shortage, different strategies are available : (i) fitting water offer to agricultural demand through the mobilisation of new resources ; (ii) fitting water demand to resource offer by genetic, agronomic, regulatory, and socio-economic measures ; (iii) developing local and participative water management programs ; (iv) compensating production or income losses through public subsidies or private insurance systems. In this communication, we present some conclusions drawn from the recent scientific joint expertise conducted by INRA on “Drought and Agriculture” in 2006. Case studies from Poitou-Charentes and Midi-Pyrénées regions were selected.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : Guillaume GuichardJean Michel RebibouDidier DuclouxDominique Simula-FaivrePierre TiberghienJean-Marc ChalopinHugues BittardPhilippe SaasFrançois M. Kleinclauss
• Organismes : Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Centre d'Investigation Clinique de Besançon Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Centre d'Investigation Clinique de Besançon
• Publié dans Urologia Internationalis le 26/10/2020

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Résumé : INTRODUCTION: The incidence of genitourinary tumors (GUT) in renal transplant recipients (RTR) is higher than in the general population. We previously reported that CD4 lymphocytopenia is associated with a high incidence of skin cancer in RTR. Here, we investigate whether persistent CD4 T cell lymphopenia is associated with GUT occurrence. PATIENTS AND METHODS: A total of 433 patients were included in this study. All patients underwent annually systematic lymphocyte subset (CD3, CD4, CD8, CD19) determination by flow cytometry. RESULTS AND CONCLUSION: During the follow-up period, 13 patients developed GUT: 6 patients a prostate adenocarcinoma (incidence 0.06%/year) and 7 patients a renal cell carcinoma (incidence 0.07%/year). The patients with GUT were older than those without. Both groups did not differ in posttransplant duration, dialysis mode and duration, induction regimen, or acute rejection history. No persistent CD4 lymphopenia was observed in the patients with GUT. Although CD4 T cell lymphopenia is associated with skin cancer in long-term RTR, it did not appear to be a risk factor for GUT. This suggests that other factors encountered in the setting of kidney transplantation (e.g., immunosuppressive drugs, end-stage renal failure, etc.) favor the development of GUT in RTR.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2008
• Auteurs : João ZilhãoFrancesco D’erricoJean-Guillaume BordesArnaud LenoblePierre-Jean TexierJean-Philippe Rigaud
• Organismes : Department of Archaeology and Anthropology De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie
• Publié dans Paleoanthropology le 22/10/2020

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Résumé : After the demonstration that no Châtelperronian/Aurignacian interstratifications existed at Roc-de-Combe, Le Piage, and El Pendo, the Grotte des Fées remained the single instance conceivably documenting the putative longterm regional contemporaneity of the two technocomplexes which is required by the “acculturation” and “imitation” models of the innovations (ornaments, decorated bone tools) that characterize the Châtelperronian. Based on our own inspection and study of the lithic and faunal collections and of the site itself, on consideration of the published and unpublished literature, and on the available dating evidence, we show that the putative interstratified deposits reported by Henri Delporte, who last excavated at the Grotte des Fées in 1951–54 and 1962, are in fact 19th-century backfill. In situ remnants may have been found in 1962, but, in the part of the site excavated at that time, Delporte failed to recognize the previously described interstratification. The stratigraphic consistency of 10 (out of the 13) radiocarbon dates available relates to the fact that those 10 dates are on samples from the conceivably in situ remnants excavated in 1962. Three samples from Level B5 date the Châtelperronian occupation to ca 39–40,000 14C BP, while seven samples from Level B1–3 relate to carnivore denning at the site throughout the ca 36,500–34,500 14C BP interval. Subsequent sporadic incursions by bearers of an Aurignacian I tool-kit are documented by diagnostic material scattered from top to bottom of the backfill deposits excavated by Delporte between 1951 and 1954. Originally, that Aurignacian material must have been contained in a surficial occupation lens capping the site's Mousterian-to-Châtelperronian stratigraphic succession.

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Fichiers liés : Art_A16-grotte-des-Fees-Paleoanthropology.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2008
• Auteurs : Philippe Saltel
• Organismes : Philosophie, Langages et Cognition

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Résumé : Première édition scientifique avec variantes entre les deux éditions préparées par l'auteur, notes et bibliographie.

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