Thomas BOUCHER

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• Type de publi. :
• Date de publi. : 28/10/2024
• Auteurs : Charline JubanThomas SauvaitreAmandine DevauxGwenaelle RocheCélia LedieuCatherine GodfraindKomla Oscar AwitorNicolas BarnichChristophe MassardMathilde BonnetDelphine Boucher
• Organismes : Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Laboratoire de Physique de Clermont Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Laboratoire de Physique de Clermont Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte

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Résumé : Colorectal cancer (CRC) is the third most common cancer worldwide, and the second leading cause of cancer mortality. Genetic, host susceptibility, immunological and environmental factors all contribute in the initiation, development or/and clinical expression of the disease. Among the environmental contaminants, titanium dioxide (TiO2) particles are of particular concern given their potential carcinogenic effects and their ubiquity in everyday consumer products. TiO2 nanoparticles may interact with the intestinal microbiota and facilitate the emergence of pathobionts such as colibactin-producing Escherichia coli (CoPEC), which abnormally colonise the colonic mucosa of CRC patients. The aim of this project is to investigate the impact of titanium dioxide on colon carcinogenesis, with a particular focus on its effects on interactions between intestinal epithelial cells and the gut microbiota, including CoPEC. In vitro, exposure of 5 different CoPEC strains isolated from CRC patients to equivalent doses to those reaching the intestine (0.1 and 1 mg.kg-1) for 24 hours resulted in a reduction in their doubling time compared to a laboratory strain. Scanning electron microscopy observations coupled with energy dispersive spectroscopy revealed adsorption events for TiO2 nanoparticles in the CoPEC 11G5 strain, while structural changes in pili were observed. In consequence of these modifications, exposure to this compound also increased the strain's ability to adhere to and proliferate in intestinal epithelial cells. In vivo, APCmin/+ mice predisposed to develop CRC were exposed to TiO2 as a food additive (E171) at a human-equivalent dose of 10 mg per kg of body weight twice a week for 27 days. Macroscopic and histological observations showed that some of the exposed individuals exhibited more advanced tumour development than the control group. The "sensitive" mice also exhibited greater dysbiosis than the "non-sensitive" and "unexposed" individuals with several overrepresented taxa that are also more abundant in CRC. Thus, in an ongoing study, APCmin/+ mice are exposed to TiO2 and/or 11G5 CoPEC strain for 56 days to determine whether TiO2 enhances both 11G5 colonisation and/or CRC development. These results collectively indicate that exposure to TiO2 may play a role in the aetiology of CRC by altering the structure and function of the intestinal microbial ecosystem. This could promote the emergence of pathobionts such as CoPEC, in addition to inducing changes that enhance their colonisation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2024
• Auteurs : Pierre-Régis BurgelIsabelle Sermet-GaudelusEmmanuelle GirodonIsabelle DurieuVéronique HoudouinCamille AudoussetJulie MaceyDominique GrenetMichele PorzioMarlène Murris-EspinPhilippe ReixMélisande BaravalleChantal BelleguicLaurent MelyJuliette VerhilleLaurence WeissMartine Reynaud-GaubertMarie MittaineRebecca HamidfarSophie RamelLaure CossonBenoit DouvryIsabelle Danner-BoucherPierre FoucaudCharlotte RoyEspérie BurnetCaroline RaynalMarie-Pierre AudrezetJennifer da SilvaClémence MartinReem KanaanNicolas CarlierIsabelle HonoréFrédérique ChedevergneElise DreanoAurélie HattonAlexandre HinzpeterIwona PrankeLaurence Le Clainche-VialaSophie MayerHarriet CorvolGuillaume ThouveninSandra de MirandaNatascha RemusBenoit DouvryLouise DuthoitThierry PerezOlivier Le RouzicNathalie WizlaClaire BonStéphanie BuiNora PoeyNathalie StremlerBérengère ColteyNadine DufeuJean LebihanAsma GabsiDelphine PouradierClaire AndréjakCinthia RamesMagali Dupuy-GrassetJeanne LanguepinChristophe MarguetStéphanie PramilBaptiste ArnouatAnnlyse FantonMichel AbelyBruno RavoninjatovoAurore BlondéAnne GuillaumotSebastien KiefferAurélie TatopoulosRaphaële Nove-JosserandCamille OhlmannThomas PerrinQuitterie ReynaudCatherine LlerenaSébastien QuétantSophie ValoisMarie-Laure DalphinBénédicte Richaud-ThiriezEric DeneuvilleRaphael ChironFloriane SocchiTiphaine BihouéeJulie MankikianThomas FlamentNathalie Coolen-AllouElsa GachelinCaroline PérissonConstance VuillardMarion DupuisWael AlkoussaSarah MarchalSylvie LeroyManuela ScalbertKarine CampbellMuriel LauransGuillaume LabbéSylvie MontcouquiolPascaline PriouPaola de CarliLydie LemonnierClémence DehillotteThierry Nouvel
• Organismes : Institut Cochin Institut Necker Enfants-Malades Université Paris Cité Hospices Civils de Lyon AP-HP Hôpital universitaire Robert-Debré [Paris] Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Centre Hospitalier Universitaire de Bordeaux Hôpital Foch [Suresnes] Service de pneumologie [Hôpital Foch] Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire [Strasbourg] Service Pneumologie-Allergologie [CHU Toulouse] Centre de Ressources et de Compétences en Mucoviscidose [CHU Toulouse] Hospices Civils de Lyon Hôpital Femme Mère Enfant [CHU - HCL] Centre National de la Recherche Scientifique Université Claude Bernard Lyon 1 Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Universitaire [Rennes] Hôpital Renée Sabran [CHU - HCL] Université Paris Cité Service de Pneumologie et Allergie - Hôpital Nord [Marseille] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire [CHU Grenoble] Fondation ILDYS Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Intercommunal de Créteil Département de pneumologie pédiatrique [CHU Créteil] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Necker - Enfants Malades [AP-HP] Université Paris Cité Université Paris Cité Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Centre de recherche sur l'Inflammation Laboratoire d'excellence Inflamex [site Bichat] École Centrale de Lyon Hôpital Cochin [AP-HP] Service de pneumologie [CHU Cochin] Université Paris Cité Hôpital Necker - Enfants Malades [AP-HP] Service de Pneumologie Allergologie [CHU Necker] Institut Necker Enfants-Malades Université Paris Cité Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades PRISMES - Langues, Textes, Arts et Cultures du Monde Anglophone - EA 4398 Sorbonne Université Mucoviscidose: physiopathologie et phénogénomique [CRSA] CHU Trousseau [APHP] Centre de Recherche Saint-Antoine CHU Trousseau [APHP] Hôpital Foch [Suresnes] Service de pneumologie [Hôpital Foch] Centre Hospitalier Intercommunal de Créteil Département de pneumologie pédiatrique [CHU Créteil] Centre Hospitalier Intercommunal de Créteil Département de pneumologie pédiatrique [CHU Créteil] Service de Pneumologie et Immuno-Allergologie [CHU LIlle] Hôpital Albert Calmette Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Hôpital Jeanne de Flandres Université de Bordeaux Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Université Paris Cité AP-HP - Hôpital Bichat - Claude Bernard [Paris] Urgences pédiatriques [Hôpital de la Timone - APHM] Assistance Publique - Hôpitaux de Marseille Centre de Recherche en Cancérologie de Marseille
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2024
• Auteurs : R. DunnJ. BlanninN. GobronJ. MillerK. WillettMelanie AdesRobert AdlerMihai AlexeRichard AllanJohn AndersonO. AnnevilleYasuyuki AonoAnthony ArguezDolores Armenteras PascualCarlo ArosioElizabeth AsherJohn AugustineCesar Azorin-MolinaOscar Baez-VillanuevaJ. BarichivichHylke BeckNicolas BellouinAngela BenedettiStephen BlenkinsopOlivier BockXavier BodinOlivier BonteMichael BosilovichOlivier BoucherStefan BuehlerMichael ByrneDiego CamposFabrizio CappucciLaura CarreaKai-Lan ChangHanne ChristiansenJohn ChristyEui-Seok ChungLaura CiastoScott ClinganMelanie Coldewey-EgbersOwen CooperRichard CornesCurt CoveyJean-François CrétauxTheresa CrimminsMolly CrotwellJoshua CulpepperDiego CusicanquiSean DavisRichard de JeuDoug DegensteinReynald DelaloyeElizabeth DigangiMartin DokulilMarkus DonatWouter DorigoDiane DucheminHilary DuganImke DurreGeoff DuttonGregory DuveillerThomas EstilowNicole EstrellaDavid FeredayVitali FioletovJohannes FlemmingMichael FosterThomas FrederikseStacey FrithLucien FroidevauxMartin FüllekrugJudith GarforthJay GargSophie Godin-BeekmannSteven GoodmanAtsushi GotoAlice GrimmAlexander GruberGuojun GuMauro GuglielminSebastian HahnLeopold HaimbergerBrad HallMerritt HarlanI. HarrisDeborah HemmingMartin HirschiShu-Peng (ben) HoRobert HolzworthRadley HortonFilip HrbáčekGuojie HuDale HurstAntje InnessKetil IsaksenViju JohnP. JonesRobert JunodAndreas KääbJohannes KaiserViktor KaufmannAndreas Kellerer-PirklbauerSergey KhaykinRichard KiddTyler KingZak KiplingAkash KoppaBenjamin KraemerR. Sofia La FuenteAlo LaasXin LanKathleen LantzJeff LapierreDavid LaversThierry LeblancEric LeibenspergerChris LennardBen LileyYakun LiuY. LoNorman LoebDiego LoyolaFlorence MagninShin-Ichiro MatsuzakiTom MatthewsMichael MayerMichael MccarthyTim McvicarCarl MearsAnnette MenzelChristopher MerchantLeo-Juhani MerioMichael MeyerDiego MirallesStephan MontzkaColin MoriceIsamu MorinoIvan MrekajJens MühleD. NanceJulien NicolasJeannette NoetzliBen NollJohn O’keefeTim OsbornMark ParringtonCécile PelletMauri PeltoKyle PetersenCoda PhillipsDon PiersonIzidine PintoStephen Po-ChedleyPaolo PogliottiLorenzo PolvaniWolfgang PreimesbergerColin PriceWilliam RandelColin RaymondSamuel RémyLucrezia RicciardulliAndrew RichardsonDavid RobinsonMatthew RodellNemesio Rodriguez-FernandezCassandra RogersP. RohiniKaren RosenlofAlexei RozanovJozef RozkošnýOlga RusanovskayaThis RutishauserC. SabeeraliRyan SaidTetsu SakaiAhira Sánchez-LugoParnchai SawaengphokhaiVerena SchenzingerRobert SchlegelMartin SchmidSonia SeneviratneFumi SezakiXi ShaoSapna SharmaLei ShiSvetlana ShimaraevaRyuichiro ShinoharaEugene SilowAdrian SimmonsSharon SmithBrian SodenViktoria SofievaLogan SoldoO. SreejithPaul StackhouseRyan StaufferWolfgang SteinbrechtAndrea SteinerPaul StoyPietro StradiottiDmitry StreletskiyGhassan TahaStephen ThackerayEmmanuel ThibertMaxim TimofeyevKleareti TourpaliEmma TronquoMari TyeRonald van der ARobin van der SchalieGerard van der SchrierArnold van VlietPiet VerburgJean-Paul VernierIsaac VimontKatrina VirtsSebastián ViveroHolger VömelRussell VoseRay WangTaran WarnockMark WeberDavid WieseJeannette WildEarle WilliamsTakmeng WongRichard Iestyn WoolwayXungang YinZhenzhong ZengLin ZhaoFeng ZhongJerry ZiemkeMarkus ZieseRuxandra ZottaCheng-Zhi Zou
• Organismes : Centre d'études spatiales de la biosphère
• Publié dans Bulletin of the American Meteorological Society le 26/10/2020

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Fichiers liés : bams-BAMS-D-24-0116.1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2024
• Auteurs : Pierre-Régis BurgelIsabelle Sermet-GaudelusEmmanuelle GirodonIsabelle DurieuVéronique HoudouinCamille AudoussetJulie MaceyDominique GrenetMichele PorzioMarlène Murris-EspinPhilippe ReixMélisande BaravalleChantal BelleguicLaurent MelyJuliette VerhilleLaurence WeissMartine Reynaud-GaubertMarie MittaineRebecca HamidfarSophie RamelLaure CossonBenoit DouvryIsabelle Danner-BoucherPierre FoucaudCharlotte RoyEspérie BurnetCaroline RaynalMarie-Pierre AudrezetJennifer da SilvaClémence MartinReem KanaanNicolas CarlierIsabelle HonoréFrédérique ChedevergneElise DreanoAurélie HattonAlexandre HinzpeterIwona PrankeLaurence Le Clainche-VialaSophie MayerHarriet CorvolGuillaume ThouveninSandra de MirandaNatascha RemusBenoit DouvryLouise DuthoitThierry PerezOlivier Le RouzicNathalie WizlaClaire BonStéphanie BuiNora PoeyNathalie StremlerBérengère ColteyNadine DufeuJean LebihanAsma GabsiDelphine PouradierClaire AndréjakCinthia RamesMagali Dupuy-GrassetJeanne LanguepinChristophe MarguetStéphanie PramilBaptiste ArnouatAnnlyse FantonMichel AbelyBruno RavoninjatovoAurore BlondéAnne GuillaumotSebastien KiefferAurélie TatopoulosRaphaële Nove-JosserandCamille OhlmannThomas PerrinQuitterie ReynaudCatherine LlerenaSébastien QuétantSophie ValoisMarie-Laure DalphinBénédicte Richaud-ThiriezEric DeneuvilleRaphael ChironFloriane SocchiTiphaine BihouéeJulie MankikianThomas FlamentNathalie Coolen-AllouElsa GachelinCaroline PérissonConstance VuillardMarion DupuisWael AlkoussaSarah MarchalSylvie LeroyManuela ScalbertKarine CampbellMuriel LauransGuillaume LabbéSylvie MontcouquiolPascaline PriouPaola de CarliLydie LemonnierClémence DehillotteThierry Nouvel
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Fichiers liés : 2024 Burgel et al., The expanded French.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/08/2024
• Auteurs : T. BoyerJ. BlundenR. DunnMelanie AdesRobert AdlerSusheel AdusumilliW. AgyakwahSomayeh AhmadpourLaura AldecoMichael AlexanderMihai AlexeEric AlfaroRichard AllanAdam AllgoodLincoln AlvesJorge AmadorDillon AmayaCharles AmoryJohn AndersonB. AndradeLiss Marie AndreassenO. AnnevilleYasuyuki AonoAnthony ArguezDolores Armenteras PascualCarlo ArosioElizabeth AsherJohn AugustineGrinia AvalosCesar Azorin-MolinaOscar Baez-VillanuevaRebecca BaimanThomas BallingerAlison BanwellM. Yu. BardinJ. BarichivichSandra BarreiraRebecca BeadlingMarc BeaucheminHylke BeckEmily BeckerBrian BeckleyE. BekeleNicolas BellouinAngela BenedettiChristine BerneLogan BernerGermar BernhardUma BhattSiiri BigalkePeter BissolliJarle BjerkeEric BlakeJosh BlanninStephen BlenkinsopOliver BochníčekOlivier BockXavier BodinOlivier BonteMichael BosilovichOlivier BoucherJason BoxDeniz BozkurtBrian BrettschneiderFrancis BringasMike BrubakerStefan BuehlerBrandon BukuntDavid BurgessAmy ButlerMichael ByrneBlanca CalderónSuzana CamargoJayaka CampbellDiego CamposFabrizio CappucciLaura CarreaBrendan CarterRandall CervenyIvona CetinićDon ChambersDuo ChanElise ChandlerKai-Lan ChangCandice CharltonJack ChenLin ChenLijing ChengVincent ChengLucy ChisholmHanne ChristiansenJohn ChristyEui-Seok ChungLaura CiastoLeonardo ClarkeKyle ClemScott ClinganCaio A.S. CoelhoMelanie Coldewey-EgbersSteve ColwellOwen CooperRichard CornesKris CorreaFelipe CostaCurt CoveyLawrence CoyJean-François CrétauxTheresa CrimminsMolly CrotwellJoshua CulpepperAna CunhaDiego CusicanquiRajashree DattaSean DavisRichard de JeuJos de LaatPranab DebBertrand DecharmeDoug DegensteinReynald DelaloyeChris DerksenHoward DiamondElizabeth DigangiS. DindyalDmitry DivineMartin DokulilMarkus DonatShenfu DongWouter DorigoCaroline Drost JensenMatthew DruckenmillerMarcel Du PlessisDiane DucheminHilary DuganDashkhuu DulamsurenImke DurreGeoff DuttonGregory DuveillerCraig Earl-SpurrPaola Echeverría GarcésMithat EkiciAlesksandra Elias CherequeShane ElipotM. ElkharrimHoward EpsteinJ.C. EspinozaThomas EstilowNicole EstrellaSinead FarrellNicolas FauchereauRobert FaustoRichard FeelyChris FenimoreDavid FeredayDenise FernandezXavier FettweisVitali FioletovJohannes FlemmingCaitlyn FlorentineChris FogartyRyan FogtBruce ForbesMichael FosterBryan FranzThomas FrederikseHelen FrickerStacey FrithLucien FroidevauxGerald FrostShanshan FuYao FuMartin FüllekrugCatherine GanterMeng GaoJudith GarforthJay GargSebastian GerlandArtur GevorgyanDonata GiglioSarah GilleJohn GilsonKarin GleasonNadine GobronSophie GodinMarlos GoesStanley GoldenbergJulio Gómez CamachoYolanda González HernándezSteven GoodmanAtsushi GotoGarrett GrahamAlice GrimmJens-Uwe GrooßAlexander GruberGuojun GuMauro GuglielminSebastian HahnLeopold HaimbergerS. HakmiBrad HallBenjamin HamlingtonEdward HannaInger Hanssen-BauerMerritt HarlanDaniel HarnosI. HarrisQiong HeMáret HeattaRichard HeimDeborah HemmingStefan HendricksJ. HicksHugo HidalgoMartin HirschiShu-Peng (ben) HoWill HobbsRobert HolzworthRadley HortonFilip HrbáčekGuojie HuZeng-Zhen HuBoyin HuangHongjie HuangDale HurstIolanda IalongoAntje InnessKetil IsaksenMasayoshi IshiiMichael JacoxGerardo JadraPiyush JainAnnika JersildJelmer JeuringSvetlana JevrejevaGensuo JiaViju JohnWilliam JohnsBjørn JohnsenBryan JohnsonGregory JohnsonP. JonesSimon JoseyG. JumauxRobert JunodAndreas KääbK. KabidiJohannes KaiserLars KaleschkeViktor KaufmannAmin Fazl KazemiLinda KellerAndreas Kellerer-PirklbauerMichael KendonJohn KennedyYelena KhalatyanValentina KhanSergey KhaykinMai Van KhiemRichard KiddRachel KillickSeong-Joong KimTyler KingZak KiplingMegan Kirchmeier-YoungPhilip KlotzbachJohn KnaffJack KohlerAkash KoppaNatalia KorshunovaBenjamin KraemerNatalya KramarovaJessica KromerA. KrugerArun KumarMikael KuuselaR. Sofia La FuenteAlo LaasZachary LabeRick LaderLeslie LaitMónika LakatosKaisa LakkalaHoang Phuc LamXin LanPeter LandschützerChris LandseaKathleen LantzJeff LapierreMark LaraWaldo Lavado-CasimiroDavid LaversMatthew LazzaraThierry LeblancSimon LeeTsz-Cheung LeeEric LeibenspergerChris LennardEric LeulietteMichelle L’heureuxJan LieserBen LileyI-I LinChao LiuYakun LiuY. LoRicardo LocarniniNorman LoebBryant LoomisHosmay LopezAndrew LorreyDiego LoyolaSusan LozierRui LuBartłomiej LuksRick LumpkinJing-Jia LuoKari LuojusJohn LymanMatthew MacanderMichael MacferrinGraeme MacgilchristMichelle MaclennanAndrew MageeFlorence MagninRúna Í. MagnússonJostein MamenKen MankoffGloria ManneyJose MarengoMohammadi MarjanAndreas MarouchosRodney MartinezRobert MassomShin-Ichiro MatsuzakiTom MatthewsMichael MayerC. McbrideMichael MccarthyClive McmahonTim McvicarCarl MearsBrooke MedleyWalter MeierAdeme MekonnenAnnette MenzelChristopher MerchantLeo-Juhani MerioMark MerrifieldMichael MeyerTristan MeyersDavid MikolajczykJohn MillerCaitlin MinneyDiego MirallesAlexey MishonovGary MitchumBen MoatAurel MoiseJorge Molina-CarpioPaul MontesanoStephan MontzkaRonald MoodyTwila MoonNatali MoraColin MoriceIsamu MorinoA. MostafaThomas MoteIvan MrekajLawrence MudrykRobi MuharsyahJens MühleRolf MüllerD. NanceChristopher NeighR. Steven NeremPaul NewmanJulien NicolasJeannette NoetzliBen NollTaylor NortonKelsey NylandJohn O’keefeMitsuho OeYuka OkunakaAlexander OrlikTim OsbornJames OverlandFinnur PálssonMark ParringtonRichard PaschReynaldo Pascual RamírezLinda PatersonCécile PelletMauri PeltoRenellys PerezDonald PerovichKyle PetersenIrina PetropavlovskikhAlek PettyAlexandre PezzaLuciano PezziCoda PhillipsGareth PhoenixDon PiersonIzidine PintoIvenis PitaMichael PittsStephen Po-ChedleyPaolo PogliottiKristin PoinarLorenzo PolvaniAmos PoratWolfgang PreimesbergerColin PriceSarah PurkeyWilly QuispeAndrea RamosWilliam RandelMarilyn RaphaelColin RaymondJames ReaganPhillip ReidSamuel RémyHans ResslLucrezia RicciardulliAndrew RichardsonRobert RickerPatricia RiveraDavid RobinsonM. RobjhonMatthew RodellEsteban Rodriguez GuisadoNemesio Rodríguez-FernándezMaarit RoebelingCassandra RogersP. RohiniVladimir RomanovskyJosyane RonchailMatthew RosencransKaren RosenlofBenjamin RösnerAlexei RozanovJozef RozkošnýOlga RusanovskayaThis RutishauserC. SabeeraliRyan SaidTetsu SakaiRoberto SalinasAhira Sánchez-LugoMichelle SanteeLouis SassKanako SatoParnchai SawaengphokhaiA. SayouriTheodore ScambosJohan SchellerVerena SchenzingerRobert SchlegelClaudia SchmidMartin SchmidCarl SchreckCristina SchulzZ. SegeleSonia SeneviratneSerhat SensoyJi-In SeongJulieta Serna CuencaMark SerrezeFumi SezakiXi ShaoSapna SharmaJia-Rui ShiLei ShiNikolay ShiklomanovSvetlana ShimaraevaRyuichiro ShinoharaR. ShuklaEugene SilowAdrian SimmonsDavid SmeedAdam SmithBenjamin SmithRyan SmithSharon SmithBrian SodenViktoria SofievaLogan SoldoEveraldo SouzaJacqueline Spence-HemmingsSandra SpillaneO. SreejithA. SrivastavaJr.Paul StackhouseSharon StammerjohnRyan StaufferWolfgang SteinbrechtAndrea SteinerJose StellaTannecia StephensonLaura StevensPaul StoyPietro StradiottiDmitry StreletskiyThea SukiantoTove SvendbyWilliam SweetGhassan TahaKiyotoshi TakahashiKazuto TakemuraMichael TaylorMarco TedescoStephen ThackerayW. ThiawEmmanuel ThibertSandy ThomallaRichard ThomanPhilip ThompsonLaura ThomsonThorsteinn ThorsteinssonXiangshan Tian-KunzeMary-Louise TimmermansMaxim TimofeyevHans TømmervikKleareti TourpaliKatja TrachteBlair TrewinJoaquin TriñanesSarat Chandra TripathyEmma TronquoAdrian TrotmanRyan TruchelutLuke TruselKatherine TurnerMari TyeJohn UehlingRonald van der ARoderick van der LindenRobin van der SchalieGerard van der SchrierCédric van MeerbeeckArnold van VlietAhad VazifePiet VerburgJean-Paul VernierIsaac VimontR. VirasamiKatrina VirtsSebastián ViveroDenis VolkovHolger VömelRussell VoseChristine WaiglJohn WalshBin WangHui WangMuyin WangRay WangRik WanninkhofTaran WarnockMark WeberMelinda WebsterAdrian WehrléRobert WellerToby WestberryMatthew WidlanskyDavid WieseJeannette WildKate WillettEarle WilliamsJosh WillisGabriel WolkenTakmeng WongKimberly WoodRichard Iestyn WoolwayBert WoutersFrancis WuDedi YangXungang YinZiqi YinLisan YuZhenzhong ZengHuai-Min ZhangPeiqun ZhangLin ZhaoFeng ZhongZhiwei ZhuJerry ZiemkeMarkus ZieseRuxandra ZottaCheng-Zhi Zou
• Organismes : Météo-France Laboratoire d'études en Géophysique et océanographie spatiales Centre national de recherches météorologiques Centre d'études spatiales de la biosphère Institut Pierre-Simon-Laplace Centre d'études spatiales de la biosphère Océan et variabilité du climat

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Résumé : Abstract —J. Blunden and T. Boyer. In 2023, La Niña conditions that generally prevailed in the eastern Pacific Ocean from mid-2020 into early 2023 gave way to a strong El Niño by October. Atmospheric concentrations of Earth’s major greenhouse gases—carbon dioxide, methane, and nitrous oxide—all increased to record-high levels. The annual global average carbon dioxide concentration in the atmosphere rose to 419.3±0.1 ppm, which is 50% greater than the pre-industrial level. The growth from 2022 to 2023 was 2.8 ppm, the fourth highest in the record since the 1960s. The combined short-term effects of El Niño and the long-term effects of increasing levels of heat-trapping gases in the atmosphere contributed to new records for many essential climate variables reported here. The annual global temperature across land and oceans was the highest in records dating as far back as 1850, with the last seven months (June–December) having each been record warm. Over land, the globally averaged temperature was also record high. Dozens of countries reported record or near-record warmth for the year, including China and continental Europe as a whole (warmest on record), India and Russia (second warmest), and Canada (third warmest). Intense and widespread heatwaves were reported around the world. In Vietnam, an all-time national maximum temperature record of 44.2°C was observed at Tuong Duong on 7 May, surpassing the previous record of 43.4°C at Huong Khe on 20 April 2019. In Brazil, the air temperature reached 44.8°C in Araçuaí in Minas Gerais on 20 November, potentially a new national record and 12.8°C above normal. The effect of rising temperatures was apparent in the cryosphere, where snow cover extent by June 2023 was the smallest in the 56-year record for North America and seventh smallest for the Northern Hemisphere overall. Heatwaves contributed to the greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Due to rapid volume loss beginning in 2021, St. Anna Glacier in Switzerland and Ice Worm Glacier in the United States disappeared completely. In August, as a direct result of glacial thinning over the past 20 years, a glacial lake on a tributary of the Mendenhall Glacier in Alaska burst through its ice dam and caused unprecedented flooding on Mendenhall River near Juneau. Across the Arctic, the annual surface air temperature was the fourth highest in the 124-year record, and summer (July–September) was record warm. Smaller-than-normal snow cover extent in May and June contributed to the third-highest average peak tundra greenness in the 24-year record. In September, Arctic minimum sea ice extent was the fifth smallest in the 45-year satellite record. The 17 lowest September extents have all occurred in the last 17 years. In Antarctica, temperatures for much of the year were up to 6°C above average over the Weddell Sea and along coastal Dronning Maud Land. The Antarctic Peninsula also experienced well-above-average temperatures during the 2022/23 melt season, which contributed to its fourth consecutive summer of above-average surface melt. On 21 February, Antarctic sea ice extent and sea ice area both reached all-time lows, surpassing records set just a year earlier. Over the course of the year, new daily record-low sea ice extents were set on 278 days. In some instances, these daily records were set by a large margin, for example, the extent on 6 July was 1.8 million km 2 lower than the previous record low for that day. Across the global oceans, the annual sea surface temperature was the highest in the 170-year record, far surpassing the previous record of 2016 by 0.13°C. Daily and monthly records were set from March onward, including an historic-high daily global mean sea surface temperature of 18.99°C recorded on 22 August. Approximately 94% of the ocean surface experienced at least one marine heatwave in 2023, while 27% experienced at least one cold spell. Globally averaged ocean heat content from the surface to 2000-m depth was record high in 2023, increasing at a rate equivalent to ∼0.7 Watts per square meter of energy applied over Earth’s surface. Global mean sea level was also record high for the 12th consecutive year, reaching 101.4 mm above the 1993 average when satellite measurements began, an increase of 8.1±1.5 mm over 2022 and the third highest year-over-year increase in the record. A total of 82 named tropical storms were observed during the Northern and Southern Hemispheres’ storm seasons, below the 1991–2020 average of 87. Hurricane Otis became the strongest landfalling hurricane on record for the west coast of Mexico at 140 kt (72 m s −1 ), causing at least 52 fatalities and $12–16 billion U.S. dollars in damage. Freddy became the world’s longest-lived tropical cyclones on record, developing into a tropical cyclone on 6 February and finally dissipating on 12 March. Freddy crossed the full width of the Indian Ocean and made one landfall in Madagascar and two in Mozambique. In the Mediterranean Sea—outside of traditional tropical cyclone basins—heavy rains and flooding from Storm Daniel killed more than 4300 people and left more than 8000 missing in Libya. The record-warm temperatures in 2023 created conditions that helped intensify the hydrological cycle. Measurements of total-column water vapor in the atmosphere were the highest on record, while the fraction of cloud area in the sky was the lowest since records began in 1980. The annual global mean precipitation total over land surfaces for 2023 was among the lowest since 1979, but global one-day maximum totals were close to average, indicating an increase in rainfall intensity. In July, record-high areas of land across the globe (7.9%) experienced extreme drought, breaking the previous record of 6.2% in July 2022. Overall, 29.7% of land experienced moderate or worse categories of drought during the year, also a record. Mexico reported its driest (and hottest) year since the start of its record in 1950. In alignment with hot and prolonged dry conditions, Canada experienced its worst national wildfire season on record. Approximately 15 million hectares burned across the country, which was more than double the previous record from 1989. Smoke from the fires were transported far into the United States and even to western European countries. August to October 2023 was the driest three-month period in Australia in the 104-year record. Millions of hectares of bushfires burned for weeks in the Northern Territory. In South America, extreme drought developed in the latter half of the year through the Amazon basin. By the end of October, the Rio Negro at Manaus, a major tributary of the Amazon River, fell to its lowest water level since records began in 1902. The transition from La Niña to El Niño helped bring relief to the prolonged drought conditions in equatorial eastern Africa. However, El Niño along with positive Indian Ocean dipole conditions also contributed to excessive rainfall that resulted in devastating floods over southeastern Ethiopia, Somalia, and Kenya during October to December that displaced around 1.5 million people. On 5 September, the town of Zagora, Greece, broke a national record for highest daily rainfall (754 mm in 21 hours, after which the station ceased reporting) due to Storm Daniel; this one-day accumulation was close to Zagora’s normal annual total.

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Fichiers liés : bams-2024BAMSStateoftheClimate_Intro.1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2024
• Auteurs : Pierre-Régis BurgelJean-Louis PaillasseurIsabelle DurieuMartine Reynaud-GaubertRebecca HamidfarMarlène Murris-EspinIsabelle Danner-BoucherRaphaël ChironSylvie LeroyBenoit DouvryDominique GrenetLaurent MelySophie RamelSylvie MontcouquiolEspérie BurnetEl Hassane OuaalayaPhilippe SogniJennifer da SilvaClémence MartinClaire AndréjakClaire PouletMarie-Chantal ChevalierMarie JouvenotCaroline MarienAudrey ParisChristine PersonPascaline PriouDidier PernetBénédicte Richaud-ThiriezPauline Roux-ClaudeNathalia BlancJulie MaceyKarine CampbellSylvie MontcouquiolMarc RuivardNatacha RemusBenoit DouvryGuillaume BeltramoAnnlyse FantonAmale Boldron-GhaddarRabah BouzioukhLaurent MelyCharles SimonRébecca HamidfarSebastien QuetantCamille AudoussetAlice GicquelloOlivier Le RouzicThierry PerezNicolas ParisMagali Dupuy-GrassetJane LanguepinIsabelle DurieuRaphaele Nove-JosserandQuitterie ReynaudBérangère ColteyNadine Desmazes-DufeuClarisse GauthierJean-Baptiste ReyMartine Reynaud-GaubertDavide CaimmiRaphael ChironMargot DevraitAnne GuillaumotLaura PerettiAngélica TiotiuIsabelle Danner-BoucherEmmanuel EschapasseSylvie LeroyJohana PradelliPierre-Régis BurgelNicolas CarlierIsabelle HonoréReem KanaanClémence MartinSandra DuryBruno RavoninjatovoClémentine VigierChantal BelleguicGraziella BrinchaultAudrey BarzicAnne Dirou-PrigentJean Le BihanSophie RamelKrista RevertThomas RoparsStéphane DominiqueChristophe MarguetHélène Morisse-PradierStéphanie PramilNathalie AllouLaurent EnaudElsa GachelinEric HuchotAnnabelle PayetCaroline PerissonSaguiraly PiyaralySophie ValoisRomain KesslerMichele PorzioLaurence BeaumontSylvie Colin de VerdiereElise CuquemelleSandra de MirandaDominique GrenetAntoine RouxCharlotte RoyMarion DupuisGuillaume FaviezGéraldine LabouretMarlène Murris-EspinLéa RoditisLaure CossonThomas FlamentCharlotte GirautJulie MankikianBaptiste ArnouatGaétane MoussetVéronique StorniPhilippe Vigneron
• Organismes : Hydrosciences Montpellier Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier]
• Publié dans Annals of the American Thoracic Society le 26/10/2020

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Résumé : ationale: Limited data exist on the safety and effectiveness of elexacaftor-tezacaftor-ivacaftor (ETI) in people with cystic fibrosis (pwCF) and advanced lung disease. Objectives: To evaluate the effects of ETI in an unselected population of pwCF and advanced lung disease. Methods: A prospective observational study, including all adults aged 18 years and older with percentage predicted forced expiratory volume in 1 second (ppFEV1) ⩽ 40 who initiated ETI from December 2019 to June 2021 in France, was conducted. PwCF were followed until August 8, 2022. Results: ETI was initiated in 434 pwCF with a median ppFEV1 of 30 (interquartile range, 25-35), including 27 with severe cystic fibrosis liver disease and 183 with diabetes. PwCF were followed for a median of 587 (interquartile range, 396-728) days after ETI initiation. Discontinuation of ETI occurred in 12 (2.8%) pwCF and was due mostly to lung transplantation (n = 5) or death (n = 4). Absolute increase in ppFEV1 by a mean of +14.2% (95% confidence interval, 13.1-15.4%) occurred at 1 month and persisted throughout the study. Increase in ppFEV1 in the youngest age quartile was almost twice that of the oldest quartile (P < 0.001); body mass index < 18.5 kg/m2 was found in 38.6% at initiation versus 11.3% at 12 months (P = 0.0001). Increases in serum concentrations of vitamins A and E, but not 25-hydroxy vitamin D3, were observed. Significant reductions in the percentages of pwCF using oxygen therapy, noninvasive ventilation, nutritional support, and inhaled and systemic therapies (including antibiotics) were observed; insulin was discontinued in 12% of patients with diabetes. Conclusions: ETI is safe in pwCF and advanced lung disease, with multisystem pulmonary and extrapulmonary benefits.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/06/2024
• Auteurs : Malte MeinshausenCarl-Friedrich SchleussnerKathleen BeyerGreg BodekerOlivier BoucherJ. CanadellJohn S DanielAïda Diongue-NiangFatima DriouechErich FischerPiers M ForsterMichael GroseGerrit HansenZeke HausfatherTatiana V. IlyinaJarmo KikstraJoyce KimutaiAndrew D KingJune-Yi LeeChris LennardTabea LissnerAlexander NauelsGlen PetersAnna PiraniGian-Kasper PlattnerHans PörtnerJoeri RogeljMaisa RojasJoyashree RoyBjørn Hallvard SamsetBenjamin M SandersonRoland SéférianSonia I. SeneviratneChristopher J. SmithSophie SzopaAdelle ThomasDiana Urge-VorsatzGuus J M VeldersTokuta YokohataTilo ZiehnZebedee Nicholls
• Organismes : Centre national de recherches météorologiques Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation du climat
• Publié dans Geoscientific Model Development le 21/10/2020

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Résumé : Abstract. In every Intergovernmental Panel on Climate Change (IPCC) Assessment cycle, a multitude of scenarios are assessed, with different scope and emphasis throughout the various Working Group reports and special reports, as well as their respective chapters. Within the reports, the ambition is to integrate knowledge on possible climate futures across the Working Groups and scientific research domains based on a small set of “framing pathways” such as the so-called representative concentration pathways (RCPs) in the Fifth IPCC Assessment Report (AR5) and the shared socioeconomic pathway (SSP) scenarios in the Sixth Assessment Report (AR6). This perspective, initiated by discussions at the IPCC Bangkok workshop in April 2023 on the “Use of Scenarios in AR6 and Subsequent Assessments”, is intended to serve as one of the community contributions to highlight the needs for the next generation of framing pathways that is being advanced under the Coupled Model Intercomparison Project (CMIP) umbrella, which will influence or even predicate the IPCC AR7 consideration of framing pathways. Here we suggest several policy research objectives that such a set of framing pathways should ideally fulfil, including mitigation needs for meeting the Paris Agreement objectives, the risks associated with carbon removal strategies, the consequences of delay in enacting that mitigation, guidance for adaptation needs, loss and damage, and for achieving mitigation in the wider context of societal development goals. Based on this context, we suggest that the next generation of climate scenarios for Earth system models should evolve towards representative emission pathways (REPs) and suggest key categories for such pathways. These framing pathways should address the most critical mitigation policy and adaptation plans that need to be implemented over the next 10 years. In our view, the most important categories are those relevant in the context of the Paris Agreement long-term goal, specifically an immediate action (low overshoot) 1.5 °C pathway and a delayed action (high overshoot) 1.5 °C pathway. Two other key categories are a pathway category approximately in line with current (as expressed by 2023) near- and long-term policy objectives, as well as a higher-emission category that is approximately in line with “current policies” (as expressed by 2023). We also argue for the scientific and policy relevance in exploring two “worlds that could have been”. One of these categories has high-emission trajectories well above what is implied by current policies and the other has very-low-emission trajectories which assume that global mitigation action in line with limiting warming to 1.5 °C without overshoot had begun in 2015. Finally, we note that the timely provision of new scientific information on pathways is critical to inform the development and implementation of climate policy. Under the Paris Agreement, for the second global stocktake, which will occur in 2028, and to inform subsequent development of nationally determined contributions (NDCs) up to 2040, scientific inputs are required by 2027. These needs should be carefully considered in the development timeline of community modelling activities, including those under CMIP7.

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Fichiers liés : gmd-17-4533-2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2024
• Auteurs : Nicolas CollonguesFrançoise Durand-DubiefChristine Lebrun-FrénayBertrand AudoinXavier AyrignacC. BensaKevin BigautBertrand BourreClarisse Carra DallièreJonathan CironGilles-Louis DeferArnaud KwiatkowskiEmmanuelle LerayElisabeth MaillartRomain MarignierGuillaume MatheyNathalie MorelEric ThouvenotHélène ZéphirJulie BoucherClémence BoutièrePierre BrangerAngélique da SilvaS. DemortièreMaxime GuillaumeBenjamin HebantEdouard JanuelAnne KerbratÉric ManchonXavier MoissetAlexis MontcuquetChloe PierretJulie PiqueJulien PoupartChloé PrunisThomas RouxPerrine SchmittGéraldine AndrodiasMikael Cohen
• Organismes : Université de Strasbourg Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Strasbourg] Observatoire Français de la Sclérose En Plaques [Lyon] Centre Hospitalier Universitaire de Nice Centre de résonance magnétique biologique et médicale CHU Montpellier = Montpellier University Hospital Institut des Neurosciences de Montpellier Fondation Ophtalmologique Adolphe de Rothschild [Paris] Université de Strasbourg Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Strasbourg] CHU Rouen CHU Montpellier = Montpellier University Hospital Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Université de Caen Normandie Université catholique de Lille École des Hautes Études en Santé Publique Université de Rennes Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé CHU Pitié-Salpêtrière [AP-HP] Observatoire Français de la Sclérose En Plaques [Lyon] Service de neurologie [CHRU Nancy] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [CHU Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Assistance Publique - Hôpitaux de Marseille Neuropsychologie et imagerie de la mémoire humaine Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Centre de résonance magnétique biologique et médicale Service de neurologie [Rouen] Service de neurologie [Rouen] CHU Pitié-Salpêtrière [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre Hospitalier Universitaire [Rennes] Neuroimagerie: méthodes et applications Centre Hospitalier de Gonesse Université Clermont Auvergne Neuro-Dol CHU de Bordeaux Pellegrin [Bordeaux] École des Hautes Études en Santé Publique Université de Rennes Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Observatoire Français de la Sclérose En Plaques [Lyon] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire de Nancy CHU Pitié-Salpêtrière [AP-HP] Institut de Cancérologie du GARD ICG - CHU Nîmes Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Université Côte d'Azur
• Publié dans Multiple Sclerosis Journal le 31/10/2020

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Résumé : Background: Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population more than 50 is more susceptible to cancer, and this risk may be increased by frequent use of immunosuppressive drugs. Consequently, concerns have arisen about the potential increased risk of cancer in PwMS and how patients should be screened and managed in terms of cancer risk. Objective: To develop evidence-based recommendations to manage the coexistence of cancer and multiple sclerosis (MS). Methods: The French Group for Recommendations in MS collected articles from PubMed and university databases covering the period January 1975 through June 2022. The RAND/UCLA method was employed to achieve formal consensus. MS experts comprehensively reviewed the full-text articles and developed the initial recommendations. A group of multidisciplinary health care specialists then validated the final proposal. Results: Five key questions were addressed, encompassing various topics such as cancer screening before or after initiating a disease-modifying therapy (DMT), appropriate management of MS in the context of cancer, recommended follow-up for cancer in patients receiving a DMT, and the potential reintroduction of a DMT after initial cancer treatment. A strong consensus was reached for all 31 recommendations. Conclusion: These recommendations propose a strategic approach to managing cancer risk in PwMS.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Thomas HussonFrançois LecoquierreGaël NicolasAnne-Claire RichardAlexandra AfenjarSéverine Audebert-BellangerCatherine BadensFrédéric BilanVaroona BizaouiAnne BolandMarie-Noëlle Bonnet-DupeyronElise Brischoux-BoucherCéline BonnetMarie BournezOdile BoutePerrine BrunelleRoseline CaumesPerrine CharlesNicolas ChatronNicolas ChatronBenjamin CognéEstelle ColinValérie Cormier-DaireRodolphe DardBenjamin DauriatJulian DelanneJean‐françois DeleuzeFlorence DemurgerAnne‐sophie Denommé‐pichonChristel DepienneAnne DieuxChristèle DubourgPatrick EderySalima El ChehadehLaurence FaivrePatricia FergelotMélanie FradinAurore GardeDavid GenevièveBrigitte Gilbert-DussardierCyril GoizetAlice GoldenbergEvan GouyAnne-Marie GuerrotAnne GuimierInès HarzallaDelphine HéronBertrand IsidorDidier LacombeXavier Le Guillou-HornBoris KerenAlma KuechlerElodie LacazeAlinoë LavillaureixDaphné LehalleGaëtan LescaJames LespinasseJonathan LévyStanislas LyonnetGodeliève MorelNolwenn Jean-MarçaisSandrine MarlinLuisa MarsiliCyril MignotDaphné LehalleMathilde NizonRobert OlasoLaurent PasquierLaurine PerrinFlorence PetitVeronique PingaultAmélie PitonFabienne PrieurAudrey PutouxMarc PlanesSylvie OdentChloé QuélinSylvia Quémener-RedonMélanie RamaMarlène RioM. RossiElise SchaeferSophie RondeauPascale Saugier-VeberThomas SmolSabine SigaudyRenaud TouraineFrédéric Tran Mau-ThemAurélien TrimouilleJulien van GilsClémence VanlerbergheValérie VantalonGabriella VeraMarie VincentAlban ZieglerOlivier GuillinDominique CampionCamille Charbonnier
• Organismes : Cancer and Brain Genomics Centre Hospitalier du Rouvray Service de Génétique [CHU Rouen] Cancer and Brain Genomics CHU Rouen Cancer and Brain Genomics Service de Génétique [CHU Rouen] Cancer and Brain Genomics CHU Trousseau [APHP] Centre Hospitalier Régional Universitaire de Brest Génétique Médicale et Génomique Fonctionnelle Marseille medical genetics - Centre de génétique médicale de Marseille Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de neurosciences expérimentales et cliniques [U 1084] Centre Hospitalier de l'Estran Centre National de Recherche en Génomique Humaine Centre hospitalier de Valence Centre de génétique humaine [CHRU Besançon] Nutrition-Génétique et Exposition aux Risques Environnementaux Service de Génétique [CHRU Nancy] Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 Centre Hospitalier Régional Universitaire [CHU Lille] Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 Institut de Génétique Médicale [CHRU Lille] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Toulouse Centre de Biologie et Pathologie Est [Bron] Physiopathologie et génétique du neurone et du muscle Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire d'Angers Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] CHI Poissy - Saint-Germain-en-Laye CHU Limoges Centre de référence des maladies rares des déficiences intellectuelles de causes rares (CHU Dijon) Génétique des anomalies du développement : GAD (CTM UMR 1231) Centre National de Recherche en Génomique Humaine Centre hospitalier Bretagne Atlantique (Morbihan) Génétique des anomalies du développement : GAD (CTM UMR 1231) CHU Dijon Institute of Human Genetics - Institut für Humangenetik [Essen] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de Génétique et Développement de Rennes Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Institut de génétique médicale d’Alsace Institut de Génétique et de Biologie Moléculaire et Cellulaire Laboratoire de Génétique Médicale Centre de référence des maladies rares des déficiences intellectuelles de causes rares (CHU Dijon) Génétique des anomalies du développement : GAD (CTM UMR 1231) Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre de référence des maladies rares des déficiences intellectuelles de causes rares (CHU Dijon) Génétique des anomalies du développement : GAD (CTM UMR 1231) Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre Hospitalier Régional Universitaire [Montpellier] CHU Dijon Institut de Neurosciences cognitives et intégratives d'Aquitaine Centre Hospitalier Universitaire de Bordeaux Cancer and Brain Genomics CHU Rouen Hospices Civils de Lyon Mécanismes en sciences intégratives du vivant Cancer and Brain Genomics CHU Rouen Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] CHU Pitié-Salpêtrière [AP-HP] Institut du Thorax [CHU Nantes] Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire de mathématiques et applications [UMR 7348] CHU Pitié-Salpêtrière [AP-HP] Institute of Human Genetics - Institut für Humangenetik [Essen] Hôpital privé de l'Estuaire [Le Havre] Institut de Génétique et Développement de Rennes CHU Pitié-Salpêtrière [AP-HP] Hospices Civils de Lyon Centre Hospitalier Métropole Savoie [Chambéry] AP-HP Hôpital universitaire Robert-Debré [Paris] Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Pitié-Salpêtrière [AP-HP] Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon) Institut du Thorax [CHU Nantes] Centre National de Recherche en Génomique Humaine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire [CHU Lille] Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Institut de génétique médicale d’Alsace Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier Régional Universitaire de Brest Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de Génétique et Développement de Rennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire de Brest Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Necker - Enfants Malades [AP-HP] Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Institut de génétique médicale d’Alsace Hôpital Necker - Enfants Malades [AP-HP] Cancer and Brain Genomics CHU Rouen Maladies RAres du DEveloppement embryonnaire et du MEtabolisme : du Phénotype au Génotype et à la Fonction - ULR 7364 Marseille medical genetics - Centre de génétique médicale de Marseille Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Génétique des anomalies du développement : GAD (CTM UMR 1231) CHU Dijon Centre Hospitalier Universitaire de Bordeaux Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) Laboratoire Maladies Rares: Génétique et Métabolisme (Bordeaux) Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Robert Debré Cancer and Brain Genomics CHU Rouen Institut du Thorax [CHU Nantes] Centre Hospitalier Universitaire d'Angers Cancer and Brain Genomics CHU Rouen Cancer and Brain Genomics CHU Rouen Cancer and Brain Genomics CHU Rouen
• Publié dans European Journal of Human Genetics le 22/10/2020

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Résumé :

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Fichiers liés : Husson et al. 2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Julie SemenchukYumi NaitoSusan C CharmanSiobhán CarrStephanie ChengBruce C MarshallAlbert FaroAlexander ElbertHector GutierrezChristopher H GossBülent KaradagPierre-Régis BurgelCarla ColomboMarco SalvatoreRita PadoanGéraldine DaneauSatenik HarutyunyanNataliya KashirskayaLaura KirwanPeter MiddletonRasa RuseckaiteIsabelle de MonestrolLutz NährlichPedro Mondejar-LopezAndreas JungJacqui van RensEgil BakkeheimAnnalisa OrentiDomenique Zomer-van OmmenLuiz Vicente Rf da Silva-FilhoFlavia Fonseca FernandesMarco ZampoliAnne L StephensonIrena KasmiOuardia DraliSabine BurghartAndrea Lakatos-KrepcikJohannes EderPeter JakschKatharina KainzMargit KallingerAlexander LeitnerMarta MozdzenAndreas PflegerSabine RennerMartin StadlingerChristina ThirEmil NuriyevHedwige BoboliElke de WachterLieven DupontSophie GohyLaurence HanssensChristiane KnoopElise LammertynVicky NowéJessica PirsonMatthieu ThimmeschEva van BraeckelKim van HoorenbeeckEef VanderhelstEduardo Piacentini FilhoRodrigo Abensur AthanazioValéria de Carvalho MartinsMarta Cristina DuarteLuciana de Freitas Velloso MonteMarcelo Bicalho de FuccioAdriana de Siqueira Carvalho KnabbenRoberta MellotiDaniela Gois MenesesGuergana PetrovaDuška Tješić-DrinkovićAndrea Vukić DugacIvan BambirPanayiotis YiallourosAlena BilkovaPavel DrevinekMilan MacekHanne Vebert OlesenTania PresslerEman Mahmoud FoudaSamya NasrAbate Yeshidinber WeldetsadikMontaha Al-IedeOlzhas AbdrakhmanovHarriet CorvolLydie Lemonnier-VideauMichel AbelyCarole Bailly PicciniChantal BelleguicTiphaine BihoueeYves BillonStéphanie BuiBoubou CamaraMarie-Christine CheraudRaphael ChironEmmanuelle Coirier DuetLaure CossonMarie-Laure DalphinIsabelle Danner BoucherSandra de MirandaEric DeneuvilleJean-Christophe DubusIsabelle DurieuRalph EpaudMichèle GerardinDominique GrenetVéronique HoudouinFrédéric HuetKanaan ReemRomain KesslerJeanne LanguepinMuriel LauransSylvie LeroyCathie LlerenaJulie MaceyJulie MankikianChristophe MarguetClémence MartinLaurent MelyMarie MittaineMarlène Murris-EspinCaroline PerissonAnne PrevotatSophie RamelCinthia RamesPhilippe ReixMarine RevillonMartine Reynaud-GaubertBénédicte Richaud-ThiriezJean-Luc RittieManuëla Scalbert-DujardinIsabelle Sermet-GaudelusVéronique StorniAurélie TatopoulosGuillaume ThouveninFrançoise TroussierLaurence WeissNathalie WizlaEva-Susanne BehlFolke BrinkmannMartin ClaßenUte Graepler-MainkaMatthias GrieseArmin GrüblJutta HammermannHelge HebestreitAndrea HeinzmannAlexander HerzAlexander KieferBirte KinderHolger KösterStefan KuhnertJochen MainzAngelika MayerSusanne NaehrigTim NiehuesThomas NüßleinKrystyna PoplawskaFelix RingshausenMarkus RoseJosef RoseneckerRenate RuppelAnette ScharschingerChristian SchroppCarsten SchwarzChristina SmacznyOlaf SommerburgSivagurunathan SutharsanSimone StolzWolfgang ThomasSabine WegeBritta WelzenbachBettina WollschlägerFilia DiamanteaElpis HatziagorouKaterina ManikaDes CoxBasil ElnazirGodfrey FletcherCedric GunaratnamEdward F MckoneBarry J PlantMalena Cohen-CymberknohMichal GurGalit LivnatMeir Mei-ZahavAnnalisa AmatoGianluca FerrariRaffaele BadolatoPiercarlo PoliFiorella BattistiniValentina DonatiElisabetta BignaminiAnna FolinoVincenzo CarnovaleCarlo CastellaniRosaria CasciaroGiuseppe CiminoMarco CipolliFrancesca LuccaMirella ColluraFrancesca FiciliValeria DaccòVanessa GaglianoGiovanna PizzamiglioValeria MencariniNicola PalladinoSalvatore LeonardiNovella RotoloMaria Cristina LucantoEster QuattromanoVincenzina LucidiFabio MajoFederico AlghisiFabiana CicirielloAntonio MancaGiuseppina LeonettiMassimo MaschioBarbara MessoreStefano PantanoGiovanna PisiCinzia SpaggiariValeria RaiaCaterina LaezzaMirco RosDonatello SalvatoreGiovanni TaccettiMichela FrancalanciPamela VitulloAnna ZolinElina AleksejevaKestutis MalakauskasValdone MisevičieneAnna-Maria CharatsiHélène De La BarrièreJosje AltenburgMichiel BannierHarry HeijermanHettie JanssensGerard KoppelmanRenske van der MeerPeter MerkusMarianne NuijsinkSuzanne TerheggenHester van der VaartGeert-Jan WesselingKarin de WinterIvana Arnaudova DanevskaTatjana Jakovska MarettiStojka FustikDaria Dziecichowicz-LatałaIrena Wojsyk-BanaszakLukasz WozniackiAdelina AmorimAna Sofia Araújo SantosSusana CastanhinhaFernanda GamboaTeresa Reis SilvaFabienne GonçalvesLuísa PereiraIoana CiucaSónia SilvaSzabo Csilla-EniköIustina StanElena AmelinaEvgeniya BoitсovaAnastasia ChernyavskayaYuliya GorinovaStanislav KrasovskiyMaria MukhinaVictoria ShermanOlga SimonovaElena KondratyevaEva BérešováNina BližnákováHana KayserováBarbara SalobirJulij ŠelbUroš KrivecAntonio José Aguilar FernandezAntonio Alvarez FernàndezFélix Baranda GarcíaMarina Blanco AparicioSilvia Castillo CorullónIsidoro Cortell-AznarInés PérezJordi Costa I ColomerMaría Cols RoigIsabel Delgado PecellínLayla Diab CáceresCarmen Luna ParedesSilvia GartnerJosé Ramón Gutiérrez MartínezInés Herrero LabargaRosa Maria Girón-MorenoEsperanza Jiménez NogueiraAdelaida Lamas FerreiroAlejandro López NeyraEnrique Blitz CastroLaura Moreno GalarragaCarlos Martin de VincenteSilvia Merlos NavarroRosa Nieto-RoyoCasilda Olveira FusterMaria Dolores PastorEstela Pérez-RuizConcepción Prados-SánchezIsabel Ramos CanceloMarta Ruiz de ValbuenaJosé R Villa AsensiVeronica Sanz SantiagoPatricia Fernández GarcíaReem Mustafa TawfeeqAdrienn BankiMarita GilljamChristina KrantzUlrika LindbergAnders LindbladChristian ClarenbachCarolin SteinackRené HageMacé SchuurmansReta FischerRachel KuscheIsabelle RochatMacé SchuurmansAnna-Lena WalterHarutai KamalapornSamia HamoudaDilber Ademhan TuralUgur OzcelikPelin AsfuroğluTuğba Şişmanlar EyüboğluAyse Tana AslanAyşen BingölNazan ÇobanoğluGizem OzcanDeniz DogruYasemin GökdemirMehmet KöseSevgi PekcanRebecca Cosgriff
• Organismes : Monash Institute of Pharmaceutical Sciences [Parkville] Monash Institute of Pharmaceutical Sciences [Parkville] Royal Brompton Hospital [London, United Kingdom] Imperial College London Cystic Fibrosis Foundation Cystic Fibrosis Foundation Cystic Fibrosis Foundation University of Alabama [Birmingham] University of Washington [Seattle] Marmara University [Kadıköy - İstanbul] Institut Cochin Universidade do Minho = University of Minho [Guimarães] Istituto Superiore di Sanità = National Institute of Health Università degli Studi di Brescia = University of Brescia Sciensano [Bruxelles] Yerevan State University Research Centre for Medical Genetics [Moscow, Russia] University College Dublin [Dublin] Westmead Hospital [Sydney] Karolinska Institutet [Stockholm] Hospices Civils de Lyon Hôpital Femme Mère Enfant [CHU - HCL] Centre National de la Recherche Scientifique Université Claude Bernard Lyon 1
• Publié dans Journal of Cystic Fibrosis le 01/11/2020

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Résumé : Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV 1 ) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV 1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV 1 pre-and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre-and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.

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Fichiers liés : impact COVID lung function JCF 2024.pdf

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