Thomas BOUCHER

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• Type de publi. : Article dans une revue
• Date de publi. : 31/05/2022
• Auteurs : Cédric AnnweilerMélinda BeaudenonJennifer GautierJustine GonsardSophie BoucherGuillaume ChapeletAstrid DarsonvalBertrand FougèreOlivier GuérinMarjorie HouvetPierre MénagerClaire Roubaud BaudronAchille TchallaJean-Claude SouberbielleJeremie RiouElsa Parot-SchinkelThomas Célarier
• Organismes : Centre Hospitalier Universitaire d'Angers Laboratoire de Psychologie des Pays de la Loire Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Laboratoire de Psychologie des Pays de la Loire Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire de Nantes = Nantes University Hospital The Enteric Nervous System in gut and brain disorders [U1235] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Régional Universitaire de Tours Laboratoire Motricité Humaine Expertise Sport Santé Laboratoire Motricité Humaine Expertise Sport Santé Université Côte d'Azur Institut de Recherche sur le Cancer et le Vieillissement COVIT-TRIAL study group COVIT-TRIAL study group Centre Hospitalier Universitaire de Bordeaux Service de Médecine Gériatrique [CHU Limoges] Université de Limoges Hôpital Necker - Enfants Malades [AP-HP] Micro et Nanomédecines Translationnelles Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Université Jean Monnet - Saint-Étienne
• Publié dans PLoS Medicine le 27/10/2020

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Résumé : Background : Vitamin D supplementation has been proposed as a treatment for Coronavirus Disease 2019 (COVID-19) based on experimental data and data from small and uncontrolled observational studies. The COvid19 and Vitamin D TRIAL (COVIT-TRIAL) study was conducted to test whether a single oral high dose of cholecalciferol (vitamin D3) administered within 72 hours after the diagnosis of COVID-19 improves, compared to standard-dose cholecalciferol, the 14-day overall survival among at-risk older adults infected with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Methods and findings : This multicenter, randomized, controlled, open-label, superiority trial involved collaboration of 9 medical centers in France. Patients admitted to the hospital units or living in nursing homes adjacent to the investigator centers were eligible if they were ≥65 years, had SARS-CoV-2 infection of less than 3 days, and at least 1 COVID-19 worsening risk factor (among age ≥75 years, SpO2 ≤94%, or PaO 2 /FiO 2 ≤300 mm Hg). Main noninclusion criteria were organ failure requiring ICU, SpO2 ≤92% despite 5 L/min oxygen, life expectancy <3 months, vitamin D supplementation >800 IU/day during the preceding month, and contraindications to vitamin D supplements. Eligible and consenting patients were randomly allocated to either a single oral high-dose (400,000 IU) or standard-dose (50,000 IU) cholecalciferol administered under medical supervision within 72 hours after the diagnosis of COVID-19. Participants and local study staff were not masked to the allocated treatment, but the Steering Committee and the Data and Safety Monitoring Board were masked to the randomization group and outcome data during the trial. The primary outcome was 14-day overall mortality. Between April 15 and December 17, 2020, of 1,207 patients who were assessed for eligibility in the COVIT-TRIAL study, 254 met eligibility criteria and formed the intention-to-treat population. The median age was 88 (IQR, 82 to 92) years, and 148 patients (58%) were women. Overall, 8 (6%) of 127 patients allocated to high-dose cholecalciferol, and 14 (11%) of 127 patients allocated to standard-dose cholecalciferol died within 14 days (adjusted hazard ratio = 0.39 [95% confidence interval [CI], 0.16 to 0.99], P = 0.049, after controlling for randomization strata [i.e., age, oxygen requirement, hospitalization, use of antibiotics, anti-infective drugs, and/or corticosteroids] and baseline imbalances in important prognostic factors [i.e., sex, ongoing cancers, profuse diarrhea, and delirium at baseline]). The number needed to treat for one person to benefit (NNTB) was 21 [NNTB 9 to ∞ to number needed to treat for one person to harm (NNTH) 46]. Apparent benefits were also found on 14-day mortality due to COVID-19 (7 (6%) deaths in high-dose group and 14 (11%) deaths in standard-dose group; adjusted hazard ratio = 0.33 [95% CI, 0.12 to 0.86], P = 0.02). The protective effect of the single oral high-dose administration was not sustained at 28 days (19 (15%) deaths in high-dose group and 21 (17%) deaths in standard-dose group; adjusted hazard ratio = 0.70 [95% CI, 0.36 to 1.36], P = 0.29). High-dose cholecalciferol did not result in more frequent adverse effects compared to the standard dose. The open-label design and limited study power are the main limitations of the study. Conclusions : In this randomized controlled trial (RCT), we observed that the early administration of high-dose versus standard-dose vitamin D3 to at-risk older patients with COVID-19 improved overall mortality at day 14. The effect was no longer observed after 28 days. Trial registration ClinicalTrials.gov NCT04344041 .

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Fichiers liés : journal.pmed.1003999.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 31/05/2022
• Auteurs : Nicole LegateThuy-Vy NguyenNetta WeinsteinArlen MollerLisa LegaultZahir VallyZuzanna TajchmanAndras N. ZsidoMiha ZrimsekZhang ChenIgnazio ZianoZoi GialitakiChris D. CearyYuna JangYijun LinYoshihiko KunisatoYuki YamadaQinyu XiaoXiaoming JiangXinkai DuElvin YaoWilliam S. RyanJohn Paul WilsonWilson Cyrus-LaiWilliam Jimenez-LealWilbert LawWenceslao UnanueW. Matthew CollinsKarley L. RichardMarek VrankaVladislav AnkushevVidar ScheiVeronika LercheVanja KovicValerija KrižanićVeselina Hristova KadrevaVera Cubela AdoricUlrich S. TranSiu Kit YeungWidad HassanRalph HoustonMichael A. MachinTiago J. S. LimaThomas OstermannThomas FrizzoTherese SverdrupThea HouseTripat GillMaksim FedotovTamar PaltrowTeodor JernsätherTasnim RahmanTanya MachinMaria Koptjevskaja-TammThomas J. HostlerTatsunori IshiiBarnabas SzasziSylwia AdamusLilian SuterSuparpit M. von BormannSumaiya HabibAnna StudzinskaDragana StojanovskaSteve M. J. JanssenStefan StiegerStefan E. SchulenbergSrinivasan TatachariSoufian AzouaghePiotr SorokowskiAgnieszka SorokowskaXin SongSofie MorbéeSavannah LewisSladjana SinkolovaDmitry GrigoryevShira Meir DrexlerShimrit DachesShelby L. LevineShawn N. GenioleShahunur AkterSelena VračarSébastien MassoniSebastiano CostaSaša ZorjanEylul SarioguzSara Morales IzquierdoSarah Suzette TshondaSara G. AlvesSara PöntinenSara Álvarez SolasSantiago Ordoñez-RiañoSanja Batić OčovajSandersan OnieSamuel LinsTheresa BiberauerSami ÇoksanSakda KhumkomAsli SacakliSusana Ruiz-FernándezSandra J. GeigerSaeideh FatahmodaresRadoslaw B. WalczakRuben BetlehemRoosevelt VilarRodrigo A. CárcamoRobert M. RossRandy McCarthyTonia BallantyneErin C. WestgateRichard M. RyanRafael GargurevichReza AfhamiDongning RenRenan P. MonteiroUlf-Dietrich ReipsNiv ReggevRobert J. Calin-JagemanRazieh PourafshariRaquel OliveiraMina Nedelcheva-DatsovaRima-Maria RahalRafael R. RibeiroTheda RadtkeRachel SearstonRachadaporn Jai-AiRedeate HabtePrzemysław ZdybekSau-Chin ChenPiyaorn WajanatinapartPrincess Lovella G. MaturanJennifer T. PerilloPeder Mortvedt IsagerPavol KačmárPaulo Manuel MacapagalMichael R. ManiaciPaulina SzwedPaul H. P. HanelPaul A. G. ForbesPatricia ArriagaBastien ParisNeha ParasharKonstantinos PapachristopoulosPablo Sebastián CorreaOndřej KáchaMárcia BernardoOlatz CamposOlalla Niño BravoOscar J. Galindo-CaballeroChisom Esther OgbonnayaOlga BialobrzeskaNatalia KiselnikovaNicolle SimonovicNoga CohenNora L. NockAlejandrina HernandezCecilie Thogersen-NtoumaniNikos NtoumanisNiklas JohannesNihan Albayrak-AydemirNicolas SayAndreas B. NeubauerNeil I. MartinNathan TorunskyNatasha Van AntwerpenNatalia Van DorenNaoyuki SunamiNikolay R. RachevNadyanna M. MajeedNadya-Daniela SchmidtKhaoula NadifNadia S. Corral-FríasNihal OuherrouNida AbbasMyrto PantaziMarc Y. LucasMartin R. VasilevMaría Victoria OrtizMuhammad Mussaffa ButtMurathan KurfalıMuhib KabirRafał MudaMaría del Carmen MC Tejada RiveraMiroslav SirotaMartin SeehuusMichal ParzuchowskiMónica ToroMonika HricovaMónica Alarcón MaldonadoPanagiotis RentzelasMaarten VansteenkisteMolly A. MetzMagdalena MarszalekMaria KareklaGiovanna MioniMinke Jasmijn BosmaMinja WesterlundMilica VdovicMichal BialekMiguel A. SilanMichele AnneMichal MisiakMaria C. GugliandoloMaurice GrinbergMariagrazia CapizziMauricio F. Espinoza BarríaMerve A. KurfaliMichael C. MensinkMikayel HarutyunyanMeetu KhoslaMegan R. DunnMax KorbmacherMatúš AdamkovičMatheus Fernando Felix RibeiroMaria TerskovaMatej HruškaMarcel MartončikMartin VoracekMartin ČadekMartha Frias-ArmentaMarta KowalMarta ToporMarta RoczniewskaMarlies OosterlinckMarkéta Braun KohlováMariola Paruzel-CzachuraMarina SabristovMarina RomanovaMarietta Papadatou-PastouMaria Louise LundMaria AntoniadiMaria Elena MagrinMarc V. JonesManyu LiManuel S. OrtizMathi ManavalanAbdumalik MuminovMałgorzata KossowskaMaja FriedemannMagdalena WielgusMadelon L.M. van HooffMarco A. C. VarellaMartyn StandageMatilde NicolottiMelissa F. ColloffMaria BradfordLeigh Ann VaughnLuis EudaveLuc VieiraJackson G. LuLina Maria Sanabria PinedaLennia MatosLaura Calderón PérezLjiljana B. LazarevicLisa M. JaremkaEline Suzanne SmitElizaveta KushnirLisa J. FergusonLisa Anton-BoicukGabriel Lins de Holanda CoelhoLina AhlgrenFrancesca LigaCarmel A. LevitanLeticia MicheliLesley-Ann GuntonLeonhard VolzMarija StojanovskaLeanne BoucherLara SamojlenkoLady Grey Javela DelgadoLada KaliskaLabadi BeatrixLara WarmelinkLuis Miguel Rojas-BersciaKaren YuKeith WylieJakub WachowiczKermeka DesaiKrystian BarzykowskiLuca KozmaKortnee EvansKomila KirgizovaBamikole B. Emmanuel AgesinMonica A. KoehnKelly WolfeTatiana KorobovaKatherine MorrisKristoffer KlevjerKevin van SchieKevin VezirianKaja DamnjanovićKatrine Krabbe ThommesenKathleen SchmidtKatarzyna FilipKarolina StaniaszekKarolina GrzechKarlijn HoyerKaris MoonSirikon KhaobunmasiriKafeel RanaKristina JanjićJordan W. SuchowJulita KielińskaJulio E. Cruz VásquezJulien ChanalJulia BeitnerJuan Camilo Vargas-NietoJose Carlos T. RoxasJennifer TaberJoan Urriago-RayoJeffrey M. PavlacicJozef BenkaJozef BavolarJosé A. SotoJonas K. OlofssonJohannes K. VilsmeierJohanna MesserschmidtJohanna Czamanski-CohenJoachim WaterschootJennifer D. MossJordane BoudesseulJeong Min LeeJulia KamburidisJennifer A. Joy-GabaJanis ZickfeldJacob F. MirandaJeroen P. H. VerharenEvgeniya HristovaJulie E. BeshearsJasna Milosevic DjordjevicJasmijn BoschJaroslava Varella ValentovaJan AntfolkJana B. BerkesselJana SchrötterJan UrbanJan Philipp RöerJames O. NortonJaime R. SilvaJade S. PickeringJáchym VintrJim UttleyJonas R. KunstIzuchukwu L. G. NdukaiheAishwarya IyerIris VilaresAleksandr IvanovIvan RopovikIsabela SulaIrena SarievaIrem Metin-OrtaIrina PrusovaIsabel PintoAndreea Ioana BozdocInês A. T. AlmeidaIlse L. PitIlker DalgarIlya ZakharovAzuka Ikechukwu ArinzeKeiko IhayaIan D. StephenBiljana GjoneskaHilmar BrohmerHeather FloweHendrik GodbersenHalil Emre KocalarMattie V. HedgebethHu Chuan-PengMohammadhasan SharifianHarry ManleyHandan AkkasNandor HajduHabiba AzabGwenaël KaminskiGustav NilsonneGulnaz AnjumGiovanni A. TravaglinoGilad FeldmanGerit PfuhlGabriela CzarnekGabriela Mariana MarcuGabriela HoferGabriel BanikGabriel Agboola AdetulaGijsbert BijlstraFrederick VerbruggenFranki Y. H. KungFrank MartelaFrancesco ForoniJacques ForestGage SingerFany MuchembledFlavio AzevedoFarnaz MosannenzadehEvelina MarinovaEva ŠtrukeljZahra EtebariEmma L. BradshawErnest BaskinElkin Oswaldo Luis GarciaErica MusserI.M.M. van SteenkisteEl Rim AhnEleanor QuestedEkaterina ProniziusEmily A. JacksonEfisio ManuntaElena AgadullinaDušana ŠakanPinar DursunOlivier DujolsDmitrii DubrovMegan WillisMurat TümerJennifer L. BeaudryDora PopovićDaniel DunleavyIkhlas DjamaiDino KrupićDora HerreraDiego VegaHongfei DuDébora MolaDesislava ChakarovaWilliam E. DavisDawn Liu HolfordDavid M. G. LewisDavid C. VaidisDaphna Hausman OzeryDanilo Zambrano RicaurteDaniel StorageDaniela SousaDaniela Serrato AlvarezDaniel BollerAnna Dalla RosaDaliborka DimovaDajana KrupićDafne MarkoDavid MoreauCrystal ReeckRita C. CorreiaCassie M. WhittClaus LammClaudio Singh SolorzanoClaudia C. von BastianClare AM SutherlandClara OverkottChristopher L. AbersonChunhui WangChristopher P. NiemiecChristiana KarashialiChris NooneFaith ChiuChiara PicciocchiCharlotte BrownlowCemre KaraarslanNicola CelliniCelia Esteban-SernaCecilia ReynaCecilia FerreyraCarlota BatresRanran LiCaterina GranoJoelle CarpentierChristian K. TamnesCynthia H.Y. FuByurakn IshkhanyanLisa BylininaBastian JaegerCarsten BundtTara Bulut AllredBranko J. VermoteAhmed BokkourNatalia BogatyrevaJiaxin ShiWilliam J. ChopikBenedict AntazoBehzad BehzadniaMaja BeckerManal M. BayyatBeatrice CoccoWei-Lun ChouVassilis BarkoukisBarbora HubenaBarbara ŽuroBalazs AczelEkaterina BaklanovaHui BaiBusra Bahar BalciPeter BabinčákBart SoenensBarnaby James Wyld DixsonAviv MokadyHeather Barry KappesMohammad AtariAnna SzalaAnna SzabelskaJohn Jamir Benzon ArutaArtur DomuratNwadiogo Chisom ArinzeArianna ModenaArca AdiguzelArash MonajemKanza Ait El ArabiAsil Ali ÖzdoğruAlex O. RothbaumAdriana Olaya TorresAndriana TheodoropoulouAnna SkowronekAnita Penić JurkovićAnisha SinghAngelos P. KassianosAndrej FindorAndree HartantoAnais Thibault LandryAna FerreiraAnabela Caetano SantosAnabel de la Rosa-GomezAmélie Gourdon-KanhukamweAlexandria M. LuxonAnna Louise TodsenAlper KarababaAllison JanakAlice PilatoAlexandre BranAlexa M. TullettAnna O. KuzminskaAnthony J. KrafnickAnum UroojAhmed KhaoudiAfroja AhmedAgata Groyecka-BernardAdrian Dahl AskelundAdeyemi AdetulaAnabel BelausAbdelilah Ca CharyateAaron L. WichmanAlina StoyanovaAnna GreenburghAndrew G. ThomasAlexios ArvanitisPatrick ForscherPeter R. MallikNicholas A. ColesJeremy K. MillerHannah MoshontzHeather L. UrryHans IjzermanDana M. Basnight-BrownCharles EbersoleChristopher R ChartierErin M. BuchananMaximilian Primbs
• Organismes : Illinois Institute of Technology Durham University University of Reading Illinois Institute of Technology Clarkson University United Arab Emirates University Wolfson Medical Vision Laboratory University of Minnesota [Twin Cities] University of Pécs [Pécs, Hungary] University of Ljubljana Department of Experimental Psychology EESC-GEM Grenoble Ecole de Management Chercheur indépendant Indiana University of Pennsylvania Chercheur indépendant University of Florida [Gainesville] Senshu University Kyushu University The University of Hong Kong Shanghai University Universiteit van Amsterdam = University of Amsterdam Claremont Graduate University [Claremont, CA ] University of Toronto Montclair State University [USA] Institut Européen d'administration des Affaires Universidad de los Andes [Bogota] The Education University of Hong Kong Universidad Adolfo Ibáñez = University Adolfo Ibañez [Santiago] Nova Southeastern University Indiana University of Pennsylvania Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Norwegian School of Economics and Business Administration Universität Heidelberg [Heidelberg] = Heidelberg University University of Belgrade [Belgrade] Josip Juraj Strossmayer University of Osijek New Bulgarian University University of Zadar Universität Wien = University of Vienna The University of Hong Kong University of East London Chercheur indépendant University of Southern Queensland Universidade de Brasilia = University of Brasilia [Brasília] Universität Witten/Herdecke Bureau d'Économie Théorique et Appliquée Norwegian School of Economics and Business Administration Macquarie University [Sydney] University of Bristol [Bristol] Wilfrid Laurier University Russian Academy of Sciences [Moscow] Chercheur indépendant Stockholm University University of Dhaka University of Southern Queensland Stockholm University Manchester Metropolitan University Department of Science and Engineering [University of Waseda] Eötvös Loránd Tudományegyetem = Eötvös Loránd University [Budapest] Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie Zürcher Hochschule für Angewandte Wissenschaften = Zurich University of Applied Sciences Suranaree University of Technology University of Dhaka Institut Catholique d'Arts et Métiers Auteur indépendant University of Nottingham Malaysia Campus Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria] The University of Mississippi [Oxford] T. A. Pai Management Institute Université Mohammed V de Rabat [Agdal] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social University of Wrocław [Poland] University of Wrocław [Poland] University of Minnesota [Twin Cities] Universiteit Gent = Ghent University = Université de Gand Chercheur indépendant Auteur indépendant Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Ruhr University Bochum = Ruhr-Universität Bochum [Bochum] Bar-Ilan University [Israël] McGill University = Université McGill [Montréal, Canada] University College of the Fraser Valley University of Dhaka University of Belgrade [Belgrade] Bureau d'Économie Théorique et Appliquée Università degli studi della Campania "Luigi Vanvitelli" = University of the Study of Campania Luigi Vanvitelli University of Maribor Department of Psychology [University of Roma "La Sapienza"] University of Warwick [Coventry] Chercheur indépendant Universidade do Porto = University of Porto Åbo Akademi University [Turku] Universidad Regional Amazonica Ikiam Universidad de Guadalajara University of Novi Sad University of New South Wales [Sydney] Universidade do Porto = University of Porto University of Cambridge [UK] Stellenbosch University University of the Western Cape Erzurum Technical University Suranaree University of Technology Chercheur indépendant Leibniz-Institut für Wissensmedien [Tübingen] Eberhard Karls Universität Tübingen = University of Tübingen Department of Biological Psychology [Amsterdam] Urmia University Opole University of Technology Josip Juraj Strossmayer University of Osijek Universidade Cruzeiro do Sul Universidad de Magallanes Macquarie University [Sydney] Northern Illinois University Indiana University of Pennsylvania University of Florida [Gainesville] Australian Catholic University Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Tarbiat Modares University [Tehran] Tilburg University [Netherlands] Universidade Federal de Mato Grosso University of Konstanz Ben-Gurion University of the Negev Ohio Dominican University University of Tehran Instituto Universitário de Lisboa Center for Research in Advanced Computing Systems Sofia University Saint Kliment Ohridski - Софийски университет „Свети Климент Охридски Max-Planck-Institut für Gesellschaftsforschung Tilburg University [Netherlands] Instituto Universitário de Lisboa Stadtverwaltung Wuppertal University of Adelaide Suranaree University of Technology Jacobs University = Constructor University [Bremen] Opole University of Technology Chercheur indépendant Suranaree University of Technology University of the Philippines Indiana University of Pennsylvania Eindhoven University of Technology [Eindhoven] University of Pavol Jozef Šafárik Ateneo de Manila University Florida Atlantic University [Boca Raton] Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie University of Essex Faculty of Psychology [Vienna] Instituto Universitário de Lisboa Université Grenoble Alpes Chercheur indépendant Concordia University [Montreal] Athens University of Economics and Business Universidad Nacional de Córdoba [Argentina] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Department of Experimental Psychology, University of Cambridge Universidade do Porto = University of Porto Universidad de Deusto Chercheur indépendant Universidad de los Andes [Bogota] Universidad Manuela Beltrán Alex Ekwueme Federal University Ndufu-Alike, Ikwo SWPS University of Social Sciences and Humanities Psychological Institute of Russian Academy of Education Kent State University Ǧāmiʿat͏̈ Hayfā = University of Haifa Case Western Reserve University [Cleveland] Universidad Nacional Autónoma de México = National Autonomous University of Mexico University of Southern Denmark University of Southern Denmark University of Oxford London School of Economics and Political Science Prague University of Economics and Business Leibniz Institute for Research and Information in Education University of Southern Queensland University of Minnesota [Twin Cities] University of Adelaide Pennsylvania State University University of Delaware [Newark] Sofia University Saint Kliment Ohridski - Софийски университет „Свети Климент Охридски Singapore Management University University of Hildesheim Chercheur indépendant Universidad de Sonora Langages HUmanités Médiations Apprentissages Interactions Numérique Jacobs University = Constructor University [Bremen] University of Oxford Universidad de Sonora Bournemouth University [Poole] Universidad Nacional de Córdoba [Argentina] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Government College University [Lahore] Stockholm University University of Dhaka Maria Curie-Sklodowska University Universidad del Desarrollo University of Essex Middlebury College University of Vermont [Burlington] SWPS University of Social Sciences and Humanities Universidad del Desarrollo University of Pavol Jozef Šafárik Chercheur indépendant University College of London [London] Universiteit Gent = Ghent University = Université de Gand University of Toronto SWPS University of Social Sciences and Humanities University of Cyprus [Nicosia] Università degli Studi di Padova = University of Padua Universiteit van Amsterdam = University of Amsterdam Åbo Akademi University [Turku] Singidunum University University of Wrocław [Poland] University of the Philippines Diliman University of Nottingham Malaysia Campus University of Wrocław [Poland] University of Oxford Università degli Studi di Messina = University of Messina New Bulgarian University Université Paul-Valéry - Montpellier 3 Universidad del Desarrollo Bilkent University [Ankara] University of Wisconsin–Milwaukee Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] University of Delhi Illinois Institute of Technology University of Bergen Western Norway University of Applied Sciences University of Prešov Universidade de Brasilia = University of Brasilia [Brasília] Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Comenius University in Bratislava University of Prešov Universität Wien = University of Vienna University of Leeds Universidad de Sonora University of Wrocław [Poland] University of Surrey SWPS University of Social Sciences and Humanities Karolinska Institutet [Stockholm] Chercheur indépendant Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] University of Silesia in Katowice Chercheur indépendant Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] National and Kapodistrian University of Athens University of Oslo University of Cyprus [Nicosia] Università degli Studi di Milano = University of Milan Manchester Metropolitan University University of Louisiana Universidad de la frontera [Tecumo, Chile] = University of La Frontera [Tecumo, Chile] = Université de La Frontera [Tecumo, Chili] University of Minnesota [Twin Cities] Chercheur indépendant Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie University of Oxford Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie Radboud University [Nijmegen] Universidade de São Paulo = University of São Paulo University of Bath [Bath] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca University of Birmingham [Birmingham] Universidad de los Andes [Bogota] Ithaca College Universidad de Navarra [Pamplona] Laboratoire de Psychologie des Cognitions Massachusetts Institute of Technology Universidad de los Andes [Bogota] Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Universidad de los Andes [Bogota] University of Belgrade [Belgrade] University of Delaware [Newark] Universiteit van Amsterdam = University of Amsterdam Chercheur indépendant Northumbria University [Newcastle] Universität Wien = University of Vienna University College Cork Åbo Akademi University [Turku] Università degli Studi di Messina = University of Messina Occidental College Julius-Maximilians-Universität Würzburg = University of Würzburg [Würsburg, Germany] Northumbria University [Newcastle] Universiteit van Amsterdam = University of Amsterdam Chercheur indépendant Nova Southeastern University University of Primorska Universidad del Rosario [Bogota] Matej Bel University University of Pécs [Pécs, Hungary] Lancaster University The University of Queensland Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Sewanee: The University of the South Emporia State University Chercheur indépendant Indiana University of Pennsylvania Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie University of Pécs [Pécs, Hungary] Murdoch University [Perth] Chercheur indépendant Adekunle Ajasin University University of Canberra The University of Edinburgh Auteur indépendant Willamette University The Arctic University of Norway [Tromsø, Norway] Erasmus University Rotterdam University of Cambridge [UK] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social The University of Western Australia University of Belgrade [Belgrade] School of Psychology and Neuroscience [University of St. Andrews] Southern Illinois University [Carbondale] Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie Chercheur indépendant Universitat de València = University of Valencia = Universidade de Valencia Stockholm University Tilburg University [Tilburg] Kingston University [London] Suranaree University of Technology University of Veterinary and Animal Sciences [Lahore, Pakistan] Chercheur indépendant Stevens Institute of Technology [Hoboken] Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie Universidad de los Andes [Bogota] Université de Genève = University of Geneva Goethe University Frankfurt = Goethe-Universität Frankfurt am Main Universidad de los Andes [Bogota] University of the Philippines Diliman Kent State University Chercheur indépendant The University of Mississippi [Oxford] University of Pavol Jozef Šafárik University of Pavol Jozef Šafárik Pennsylvania State University Stockholm University Universität Wien = University of Vienna Leipzig University / Universität Leipzig Ǧāmiʿat͏̈ Hayfā = University of Haifa Universiteit Gent = Ghent University = Université de Gand Emporia State University Universidad de Lima Georgia State University Sofia University Saint Kliment Ohridski - Софийски университет „Свети Климент Охридски Virginia Commonwealth University Aarhus University [Aarhus] University of Alabama [Tuscaloosa] University of California [Berkeley] New Bulgarian University University of Southern Indiana Singidunum University Università degli Studi di Milano-Bicocca = University of Milano-Bicocca Universidade de São Paulo = University of São Paulo Åbo Akademi University [Turku] University of Mannheim = Universität Mannheim University of Pavol Jozef Šafárik Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] Universität Witten/Herdecke Murdoch University [Perth] Universidad del Desarrollo University of Manchester [Manchester] Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] University of Sheffield [Sheffield] University of Oslo Alex Ekwueme Federal University Ndufu-Alike, Ikwo Bangalore University University of Minnesota [Twin Cities] Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic] University of Prešov Chercheur indépendant Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Atilim University Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Universidade do Porto = University of Porto Universitatea "Lucian Blaga" Sibiu Universidade de Coimbra = University of Coimbra [Portugal] University of Oxford Ankara University School of Medicine [Turkey] St. Petersburg Academic University–Nanotechnology Research and Education Centre of the Russian Academy of Sciences Alex Ekwueme Federal University Ndufu-Alike, Ikwo Fukuoka Institute of Technology Nottingham Trent University Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] Graz University of Technology [Graz] University of Birmingham [Birmingham] Chercheur indépendant Muğla Sıtkı Koçman Üniversitesi [Türkiye Cumhuriyetı] = Muğla Sıtkı Koçman University [Türkiye] = Université Sıtkı Koçman de Muğla [Turquie] Virginia Commonwealth University Nanjing Normal University University of Tehran Chulalongkorn University [Bangkok] Ankara University = Ankara Üniversitesi Eötvös Loránd Tudományegyetem = Eötvös Loránd University [Budapest] Baylor College of Medicine Cognition, langues, langage, ergonomie Karolinska Institutet [Stockholm] Stockholm University Simon Fraser University = Université Simon Fraser Royal Holloway [University of London] The University of Hong Kong The Arctic University of Norway [Tromsø, Norway] Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie Universitatea "Lucian Blaga" Sibiu University of Medicine and Pharmacy “Carol Davila” Graz University of Technology [Graz] University of Prešov Adekunle Ajasin University Radboud University [Nijmegen] Universiteit Gent = Ghent University = Université de Gand Purdue University [West Lafayette] Aalto University Australian Catholic University Université du Québec à Montréal = University of Québec in Montréal Indiana University of Pennsylvania Tecnológico de Monterrey = Monterrey Institute of Technology Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] Radboud University [Nijmegen] Sofia University Saint Kliment Ohridski - Софийски университет „Свети Климент Охридски Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] Ferdowsi University of Mashhad Australian Catholic University Chercheur indépendant Universidad de Navarra [Pamplona] Florida International University [Miami] Universiteit Leiden = Leiden University University of Florida [Gainesville] Curtin University Universität Wien = University of Vienna Indiana University of Pennsylvania Cognition, langues, langage, ergonomie Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] University of Novi Sad Afyon Kocatepe University Université Grenoble Alpes Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] Australian Catholic University Hacettepe University = Hacettepe Üniversitesi Swinburne University of Technology [Melbourne] Institute of Social Sciences Ivo Pilar Florida State University [Tallahassee] Université Mohammed V de Rabat [Agdal] Josip Juraj Strossmayer University of Osijek Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Universidad Latina de Costa Rica Beijing Normal University Universidad Nacional de Córdoba [Argentina] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] New Bulgarian University Martin-Luther-Universität Halle Wittenberg - Martin-Luther-University Halle Wittenberg University of Essex Murdoch University [Perth] Laboratoire de Psychologie Sociale : contextes et régulation California State University [Northridge] Fundación Universitaria Konrad Lorenz = Konrad Lorenz University Foundation University of Denver Universidade de Coimbra = University of Coimbra [Portugal] Fundación Universitaria Konrad Lorenz = Konrad Lorenz University Foundation University of St.Gallen Università degli Studi di Padova = University of Padua Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] Chercheur indépendant University of Ljubljana University of Auckland [Auckland] Temple University [Philadelphia] Universidade do Porto = University of Porto University of Alabama [Tuscaloosa] Universität Wien = University of Vienna Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] University of Sheffield [Sheffield] University of Aberdeen The University of Western Australia Universität Zürich [Zürich] = University of Zurich California Polytechnic State University [San Luis Obispo] Chinese Center for Disease Control and Prevention University of Rochester [USA] University of Cyprus [Nicosia] National University of Ireland [Galway] University of Essex Università di Napoli L'Orientale = University of Naples University of Southern Queensland Başkent University Hospital [Adana, Turkey] Università degli Studi di Padova = University of Padua University College of London [London] Universidad Nacional de Córdoba [Argentina] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru Franklin and Marshall College Vrije Universiteit Amsterdam [Amsterdam] Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome] Université du Québec à Montréal = University of Québec in Montréal University of Oslo University of East London Institute of Psychiatry, Psychology & Neuroscience, King's College London Aarhus University [Aarhus] Universiteit Leiden = Leiden University Vrije Universiteit Amsterdam [Amsterdam] Tilburg University [Tilburg] University of Oslo University of Belgrade [Belgrade] Universiteit Gent = Ghent University = Université de Gand Université Mohammed V de Rabat [Agdal] Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] The University of Hong Kong Michigan State University [East Lansing] José Rizal University University of Tabriz [Tabriz] Cognition, langues, langage, ergonomie The University of Jordan Chercheur indépendant Chercheur indépendant Aristotle University of Thessaloniki Chercheur indépendant Josip Juraj Strossmayer University of Osijek Eötvös Loránd Tudományegyetem = Eötvös Loránd University [Budapest] Lomonosov Moscow State University = Université d'État Lomonossov de Moscou [Moscou] Stanford University Samsun university Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] University of Prešov Universiteit Gent = Ghent University = Université de Gand University of the Sunshine Coast Ben-Gurion University of the Negev London School of Economics and Political Science University of Southern California Oakland University Queen's University [Belfast] De La Salle University [Manila] Kozminski University Alex Ekwueme Federal University Ndufu-Alike, Ikwo Università degli studi di Trieste = University of Trieste Muğla Sıtkı Koçman Üniversitesi [Türkiye Cumhuriyetı] = Muğla Sıtkı Koçman University [Türkiye] = Université Sıtkı Koçman de Muğla [Turquie] University of Tehran Université Mohammed V de Rabat [Agdal] Üsküdar university Case Western Reserve University [Cleveland] Universidad del Desarrollo University of Essex Chercheur indépendant Auteur indépendant Auteur indépendant Cyprus University of Technology University College of London [London] Comenius University in Bratislava Auteur indépendant Concordia University [Montreal] Universidade de Coimbra = University of Coimbra [Portugal] Universidade de Lisboa = University of Lisbon = Université de Lisbonne Universidad Nacional Autónoma de México = National Autonomous University of Mexico Kingston University [London] King‘s College London Institute for Globally Distributed Open Research and Education Illinois Institute of Technology School of Psychology and Neuroscience [University of St. Andrews] Muğla Sıtkı Koçman Üniversitesi [Türkiye Cumhuriyetı] = Muğla Sıtkı Koçman University [Türkiye] = Université Sıtkı Koçman de Muğla [Turquie] New York University [New York] Università degli studi di Trieste = University of Trieste Laboratoire de Psychologie Sociale : contextes et régulation University of Alabama [Tuscaloosa] Uniwersytet Warszawski [Polska] = University of Warsaw [Poland] = Université de Varsovie [Pologne] Ohio Dominican University La Trobe University Université Mohammed V de Rabat [Agdal] University of Limerick University of Wrocław [Poland] Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University Lovisenberg Diakonale Sykehus - Lovisenberg Diaconal Hospital [Oslo] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social Alex Ekwueme Federal University Ndufu-Alike, Ikwo Universidad Nacional de Córdoba [Argentina] Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] LIRNE-EIMA [Kenitra] Western Kentucky University Sofia University Saint Kliment Ohridski - Софийски университет „Свети Климент Охридски University College of London [London] University College of London [London] Swansea University University of Crete [Heraklion] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social Chercheur indépendant Harvard University Stanford University Willamette University University of Wisconsin-Madison Tufts University [Medford] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social University of Nairobi University of Virginia Chercheur indépendant Penn State Harrisburg Radboud University [Nijmegen]
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment ( n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges.

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Fichiers liés : PSA_pnas_2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/05/2022
• Auteurs : Nicole LegateThuy-Vy NguyenNetta WeinsteinArlen MollerLisa LegaultZahir VallyZuzanna TajchmanAndras ZsidoMiha ZrimsekZhang ChenIgnazio ZianoZoi GialitakiChris CearyYuna JangYijun LinYoshihiko KunisatoYuki YamadaQinyu XiaoXiaoming JiangXinkai DuElvin YaoWilliam RyanJohn Paul WilsonWilson Cyrus-LaiWilliam Jimenez-LealWilbert LawWenceslao UnanueW. Matthew CollinsKarley RichardMarek VrankaVladislav AnkushevVidar ScheiVeronika LercheVanja KovicValerija KrižanićVeselina Hristova KadrevaVera Cubela AdoricUlrich TranSiu Kit YeungWidad HassanRalph HoustonMichael MachinTiago LimaThomas OstermannThomas FrizzoTherese SverdrupThea HouseTripat GillMaksim FedotovTamar PaltrowTeodor JernsätherTasnim RahmanTanya MachinMaria Koptjevskaja-TammThomas HostlerTatsunori IshiiBarnabas SzasziSylwia AdamusLilian SuterSuparpit von BormannSumaiya HabibAnna StudzinskaDragana StojanovskaSteve JanssenStefan StiegerStefan SchulenbergSrinivasan TatachariSoufian AzouaghePiotr SorokowskiAgnieszka SorokowskaXin SongSofie MorbéeSavannah LewisSladjana SinkolovaDmitry GrigoryevShira Meir DrexlerShimrit DachesShelby LevineShawn GenioleShahunur AkterSelena VračarSébastien MassoniSebastiano CostaSaša ZorjanEylul SarioguzSara Morales IzquierdoSarah Suzette TshondaSara AlvesSara PöntinenSara Álvarez SolasSantiago Ordoñez-RiañoSanja Batić OčovajSandersan OnieSamuel LinsTheresa BiberauerSami ÇoksanSakda KhumkomAsli SacakliSusana Ruiz-FernándezSandra GeigerSaeideh FatahmodaresRadoslaw WalczakRuben BetlehemRoosevelt VilarRodrigo CárcamoRobert RossRandy McCarthyTonia BallantyneErin WestgateRichard RyanRafael GargurevichReza AfhamiDongning RenRenan MonteiroUlf-Dietrich ReipsNiv ReggevRobert Calin-JagemanRazieh PourafshariRaquel OliveiraMina Nedelcheva-DatsovaRima-Maria RahalRafael RibeiroTheda RadtkeRachel SearstonRachadaporn Jai-AiRedeate HabtePrzemysław ZdybekSau-Chin ChenPiyaorn WajanatinapartPrincess Lovella G. MaturanJennifer PerilloPeder Mortvedt IsagerPavol KačmárPaulo Manuel MacapagalMichael ManiaciPaulina SzwedPaul HanelPaul ForbesPatricia ArriagaBastien ParisNeha ParasharKonstantinos PapachristopoulosPablo Sebastián CorreaOndřej KáchaMárcia BernardoOlatz CamposOlalla Niño BravoOscar Galindo-CaballeroChisom Esther OgbonnayaOlga BialobrzeskaNatalia KiselnikovaNicolle SimonovicNoga CohenNora NockAlejandrina HernandezCecilie Thogersen-NtoumaniNikos NtoumanisNiklas JohannesNihan Albayrak-AydemirNicolas SayAndreas NeubauerNeil MartinNathan TorunskyNatasha Van AntwerpenNatalia Van DorenNaoyuki SunamiNikolay RachevNadyanna MajeedNadya-Daniela SchmidtKhaoula NadifNadia Corral-FríasNihal OuherrouNida AbbasMyrto PantaziMarc LucasMartin VasilevMaría Victoria OrtizMuhammad Mussaffa ButtMurathan KurfalıMuhib KabirRafał MudaMaría del Carmen Mc Tejada RiveraMiroslav SirotaMartin SeehuusMichal ParzuchowskiMónica ToroMonika HricovaMónica Alarcón MaldonadoPanagiotis RentzelasMaarten VansteenkisteMolly MetzMagdalena MarszalekMaria KareklaGiovanna MioniMinke Jasmijn BosmaMinja WesterlundMilica VdovicMichal BialekMiguel A SilanMichele AnneMichal MisiakMaria GugliandoloMaurice GrinbergMariagrazia CapizziMauricio Espinoza BarríaMerve KurfaliMichael MensinkMikayel HarutyunyanMeetu KhoslaMegan DunnMax KorbmacherMatúš AdamkovičMatheus Fernando Felix RibeiroMaria TerskovaMatej HruškaMarcel MartončikMartin VoracekMartin ČadekMartha Frias-ArmentaMarta KowalMarta ToporMarta RoczniewskaMarlies OosterlinckMarkéta Braun KohlováMariola Paruzel-CzachuraMarina SabristovMarina RomanovaMarietta Papadatou-PastouMaria Louise LundMaria AntoniadiMaria Elena MagrinMarc JonesManyu LiManuel OrtizMathi ManavalanAbdumalik MuminovMałgorzata KossowskaMaja FriedemannMagdalena WielgusMadelon L.M. van HooffMarco VarellaMartyn StandageMatilde NicolottiMelissa ColloffMaria BradfordLeigh Ann VaughnLuis EudaveLuc VieiraJackson LuLina Maria Sanabria PinedaLennia MatosLaura Calderón PérezLjiljana LazarevicLisa JaremkaEline Suzanne SmitElizaveta KushnirLisa FergusonLisa Anton-BoicukGabriel Lins de Holanda CoelhoLina AhlgrenFrancesca LigaCarmel LevitanLeticia MicheliLesley-Ann GuntonLeonhard VolzMarija StojanovskaLeanne BoucherLara SamojlenkoLady Grey Javela DelgadoLada KaliskaLabadi BeatrixLara WarmelinkLuis Miguel Rojas-BersciaKaren YuKeith WylieJakub WachowiczKermeka DesaiKrystian BarzykowskiLuca KozmaKortnee EvansKomila KirgizovaBamikole Emmanuel AgesinMonica KoehnKelly WolfeTatiana KorobovaKatherine MorrisKristoffer KlevjerKevin van SchieKevin VezirianKaja DamnjanovićKatrine Krabbe ThommesenKathleen SchmidtKatarzyna FilipKarolina StaniaszekKarolina GrzechKarlijn HoyerKaris MoonSirikon KhaobunmasiriKafeel RanaKristina JanjićJordan SuchowJulita KielińskaJulio Cruz VásquezJulien ChanalJulia BeitnerJuan Camilo Vargas-NietoJose Carlos T. RoxasJennifer TaberJoan Urriago-RayoJeffrey PavlacicJozef BenkaJozef BavolarJosé SotoJonas OlofssonJohannes VilsmeierJohanna MesserschmidtJohanna Czamanski-CohenJoachim WaterschootJennifer MossJordane BoudesseulJeong Min LeeJulia KamburidisJennifer Joy-GabaJanis ZickfeldJacob MirandaJeroen VerharenEvgeniya HristovaJulie BeshearsJasna Milosevic DjordjevicJasmijn BoschJaroslava Varella ValentovaJan AntfolkJana BerkesselJana SchrötterJan UrbanJan Philipp RöerJames NortonJaime SilvaJade PickeringJáchym VintrJim UttleyJonas KunstIzuchukwu NdukaiheAishwarya IyerIris VilaresAleksandr IvanovIvan RopovikIsabela SulaIrena SarievaIrem Metin-OrtaIrina PrusovaIsabel PintoAndreea Ioana BozdocInês AlmeidaIlse PitIlker DalgarIlya ZakharovAzuka Ikechukwu ArinzeKeiko IhayaIan StephenBiljana GjoneskaHilmar BrohmerHeather FloweHendrik GodbersenHalil Emre KocalarMattie HedgebethHu Chuan-PengMohammadhasan SharifianHarry ManleyHandan AkkasNandor HajduHabiba AzabGwenael KaminskiGustav NilsonneGulnaz AnjumGiovanni TravaglinoGilad FeldmanGerit PfuhlGabriela CzarnekGabriela Mariana MarcuGabriela HoferGabriel BanikGabriel Agboola AdetulaGijsbert BijlstraFrederick VerbruggenFranki KungFrank MartelaFrancesco ForoniJacques ForestGage SingerFany MuchembledFlavio AzevedoFarnaz MosannenzadehEvelina MarinovaEva ŠtrukeljZahra EtebariEmma BradshawErnest BaskinElkin Oswaldo Luis GarciaErica MusserI.M.M. van SteenkisteEl Rim AhnEleanor QuestedEkaterina ProniziusEmily JacksonEfisio ManuntaElena AgadullinaDušana ŠakanPinar DursunOlivier DujolsDmitrii DubrovMegan WillisMurat TümerJennifer BeaudryDora PopovićDaniel DunleavyIkhlas DjamaiDino KrupićDora HerreraDiego VegaHongfei DuDébora MolaDesislava ChakarovaWilliam DavisDawn Liu HolfordDavid LewisDavid VaidisDaphna Hausman OzeryDanilo Zambrano RicaurteDaniel StorageDaniela SousaDaniela Serrato AlvarezDaniel BollerAnna Dalla RosaDaliborka DimovaDajana KrupićDafne MarkoDavid MoreauCrystal ReeckRita CorreiaCassie WhittClaus LammClaudio Singh SolorzanoClaudia von BastianClare Am SutherlandClara OverkottChristopher AbersonChunhui WangChristopher NiemiecChristiana KarashialiChris NooneFaith ChiuChiara PicciocchiCharlotte BrownlowCemre KaraarslanNicola CelliniCelia Esteban-SernaCecilia ReynaCecilia FerreyraCarlota BatresRanran LiCaterina GranoJoelle CarpentierChristian TamnesCynthia H.Y. FuByurakn IshkhanyanLisa BylininaBastian JaegerCarsten BundtTara Bulut AllredBranko VermoteAhmed BokkourNatalia BogatyrevaJiaxin ShiWilliam ChopikBenedict AntazoBehzad BehzadniaMaja BeckerManal BayyatBeatrice CoccoWei-Lun ChouVassilis BarkoukisBarbora HubenaBarbara ŽuroBalazs AczelEkaterina BaklanovaHui BaiBusra Bahar BalciPeter BabinčákBart SoenensBarnaby James Wyld DixsonAviv MokadyHeather Barry KappesMohammad AtariAnna SzalaAnna SzabelskaJohn Jamir Benzon ArutaArtur DomuratNwadiogo Chisom ArinzeArianna ModenaArca AdiguzelArash MonajemKanza Ait El ArabiAsil Ali ÖzdoğruAlex RothbaumAdriana Olaya TorresAndriana TheodoropoulouAnna SkowronekAnita Penić JurkovićAnisha SinghAngelos KassianosAndrej FindorAndree HartantoAnais Thibault LandryAna FerreiraAnabela Caetano SantosAnabel de la Rosa-GomezAmélie Gourdon-KanhukamweAlexandria LuxonAnna Louise TodsenAlper KarababaAllison JanakAlice PilatoAlexandre BranAlexa TullettAnna KuzminskaAnthony KrafnickAnum UroojAhmed KhaoudiAfroja AhmedAgata Groyecka-BernardAdrian Dahl AskelundAdeyemi AdetulaAnabel BelausAbdelilah Ca CharyateAaron WichmanAlina StoyanovaAnna GreenburghAndrew ThomasAlexios ArvanitisPatrick ForscherPeter MallikNicholas ColesJeremy MillerHannah MoshontzHeather UrryHans IjzermanDana Basnight-BrownCharles EbersoleChristopher ChartierErin BuchananMaximilian Primbs
• Organismes : Illinois Institute of Technology Durham University University of Reading Illinois Institute of Technology Clarkson University United Arab Emirates University Wolfson Medical Vision Laboratory University of Minnesota [Twin Cities] University of Ljubljana Laboratoire Traitement du Signal et de l'Image Laboratory of Image Science and Technology [Nanjing] EESC-GEM Grenoble Ecole de Management Chercheur indépendant Chercheur indépendant University of Florida [Gainesville] Senshu University Kyushu University The University of Hong Kong Xidian University Universiteit van Amsterdam = University of Amsterdam
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment ( n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one’s core values) or behavioral intentions. Results supported hypothesized associations between people’s existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges.

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Fichiers liés : et-al-2022-a-global-experiment-on-motivating-social-distancing-during-the-covid-19-pandemic.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2022
• Auteurs : Raphaël HahnThomas BattardOscar BoucherYan PicardHans LignierDaniel ComparatNolwenn-Amandine KerielColin LopezEmanuel OswaldMorgan ReveillardMatthieu Viteau
• Organismes : Laboratoire Lumière, Matière et Interfaces Laboratoire Lumière, Matière et Interfaces Orsay Physics Orsay Physics
• Publié dans Review of Scientific Instruments le 02/11/2020

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Résumé : We have performed a study of several cesium oven designs. A comparison between recirculating (or sticking-wall) and collimating (or re-emitting-wall) ovens is made in order to extract the most efficient design in terms of beam brightness. Unfortunately, non-reproducible behaviors have been observed, and the most often observed output flux is similar to the sticking-wall case, which is the lowest theoretical value of the two cases, with a beam brightness close to 10 18 at. sr −1 s −1 cm −2 . The reason of this universally observed behavior is unclear despite having tested several materials for the collimating tube. Conclusion on possible improved design based on sticking of cesium on several (un)cleaned surfaces is given.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2022
• Auteurs : Thomas PuechValentin PyAmandine Durpoix
• Organismes : Agro-Systèmes Territoires Ressources Mirecourt Agro-Systèmes Territoires Ressources Mirecourt Agro-Systèmes Territoires Ressources Mirecourt
• Publié dans Fourrages le 29/10/2020

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Résumé : La diversification et l’autonomie sont des pistes à explorer pour engager les systèmes agricoles vers la transition agro-écologique. L’expérimentation système INRAE ASTER Mirecourt met en place depuis 2016 un système de polyculture-élevage autonome et diversifié. Dans ce cadre, entre 15 et 30 porcs à l’engraissement sont élevés en plein air intégral chaque année depuis 2017, avec l’objectif de valoriser les productions issues des autres ateliers du système et non commercialisables en alimentation humaine. Nous montrons que les choix de conception du système entrainent (i) une hétérogénéité des performances que nous décrivons à partir de 4 profils de performances (croissance, poids carcasse, rendement boucher) et (ii) que cette hétérogénéité est présente tant au sein qu’entre les bandes de porcs. L’inscription de ce système dans des circuits courts de commercialisation permet de valoriser cet atelier de diversification peu adapté aux filières spécialisées.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2022
• Auteurs : Rébecca LajaunieLise CuzinRomain PalichAlain MakinsonFirouzé Bani-SadrClaudine DuvivierCedric ArvieuxDavid ReyIsabelle Poizot‐martinCyrille DelpierrePierre DelobelGuillaume Martin-BlondelC ChirouzeC Drobacheff-ThiébautA FoltzerKevin BouillerL Hustache-MathieuQ LepillerF BozonO BabreA S BrunelP MuretE ChevalierC JacometH LaurichesseO LesensM VidalN MrozekAumeran C.O BaudV CorbinE GoncalvezA MirandA BrebionC HenquellI LamauryI FabreE CurlierR OuissaC Herrmann-StorckB TressieresM C ReceveurF BoulardC DanielC ClavelP M RogerS MarkowiczN Chellum RungenD MerrienP PerréT GuimardO BollangierS LeautezM MorrierL LaineD BoucherP PointL CotteF AderA BeckerA BoibieuxC BrochierF Brunel-DalmasO CannessonP ChiarelloC ChidiacS DegroodtT FerryM GodinotJ M LivrozetD MakhloufiP MiailhesT PerpointM PerryC PouderouxS RouxC Triffault-FillitF ValourC CharreV IcardJ C TardyM a TrabaudI RavauxA MénardA y BelkhirP ColsonC DhiverA MadridM Martin-DegioanniL MeddebM MokhtariA MotteA RaouxC ToméiH Tissot-DupontI Poizot-MartinS BrégigeonO Zaegel-FaucherV Obry-RoguetH LarocheM OrticoniM J SoaviE RessiotM J DucassouI JaquetS GalieH ColsonA S RitlengA IvanovaC DebreuxC LionsT Rojas-RojasA CabiéS AbelJ BavayB BigeardO CabrasL CuzinR Dupin de MajoubertL FagourK GuitteaudA MarquiseF NajioullahS Pierre-FrançoisJ PasquierP RichardK RomeJ M TurmelC VaracheN AtouiM BistoquetE DelaporteV Le MoingA MakinsonN MeftahC Merle de BoeverB MontesA Montoya FerrerE TuaillonJ ReynesB LefèvreE JeanmaireS HénardE FrentiuA CharmillonA LegoffN TissotM AndréL BoyerM P BouillonM DelestanF GoehringerS BevilacquaC RabaudT MayF RaffiC AllavenaO AubryE BillaudC BironB BonnetS BouchezD BoutoilleC Brunet-CartierC DeschanvresB J GaboritA GrégoireM GrégoireO GrossiR GuéryT JovelinM LefebvreP Le TurnierR LecomteP MorineauV ReliquetS SécherM CavellecE ParedesA SoriaV FerréE André-GarnierA RodallecP PuglieseS BreaudC CeppiD ChirioE CuaP DellamonicaE DemonchyA de MonteJ DurantC EtienneS FerrandoR GarraffoC MichelangeliV MondainA NaqviN OranI PerbostM CarlesC KlotzA MakaC PradierB Prouvost-KellerK RissoV RioE RosenthalI TouitouS Wehrlen-PuglieseG ZouzouL HocquelouxT PrazuckC GubavuA SèveS GiachéV RzepeckiM ColinC BoulardG ThomasA CheretC GoujardY QuertainmontE TeicherN LerolleS JaureguiberryR ColarinoO DeradjiA CastroA Barrail-TranY YazdanpanahR LandmanV JolyJ GhosnC RiouxS LarivenA GervaisF X LescureS MatheronF LouniZ JuliaS Le GacC CharpentierD DescampsG PeytavinC DuvivierC AguilarF Alby-LaurentK AmazzoughG BenabdelmoumenP BossiG CessotC CharlierP H ConsignyK JidarE LafontF LanternierJ LeporrierO LortholaryC LouisinJ LourencoP ParizeB PilmisC RouzaudF TouamM a ValantinR TubianaR AgherS SeangL SchneiderR PalichC BlancC KatlamaF Bani-SadrJ L BergerY N'GuyenD LambertI KmiecM HentzienA BrunetJ RomaruH MartyV BrodardC ArvieuxP TattevinM RevestF SoualaM BaldeyrouS Patrat-DelonJ M ChapplainF BenezitM DupontM PoinotA MaillardC PronierF LemaitreC MorlatM Poisson-VannierT JovelinJ P SinteffA Gagneux-BrunonE Botelho-NeversA FrésardV RonatF LuchtD ReyP FischerM PartisaniC CheneauM PriesterM L BatardC MélounouC Bernard-HenryE de MautortS Fafi-KremerP DelobelM AlvarezN BiezunskiA DebardC DelpierreG GaubeP LansalotL LelièvreM MarcelG Martin-BlondelM PiffautL PorteK SauneO RobineauF AjanaE AïssiI AlcarazE AlidjinouV BacletL BocketA BoucherM DigumberT HuleuxB Lafon-DesmursA MeybeckM PradierM TetartP ThillN VigetM Valette
• Organismes : Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Equipe EQUITY (CERPOP) CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Département Maladies Infectieuses et Tropicales [CHRU Montpellier] Hôpital universitaire Robert Debré [Reims] Service des Maladies infectieuses et tropicales [CHU Necker] Imagine - Institut des maladies génétiques (IHU) Institut Cochin Centre Médical de l'Institut Pasteur Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire [Strasbourg] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Equipe EQUITY (CERPOP) Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Régional Universitaire de Besançon EMERGEN consortium Science des Procédés Céramiques et de Traitements de Surface CHU Clermont-Ferrand Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] CHU Clermont-Ferrand Queen's University [Kingston, Canada] Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand] Laboratoire Microorganismes : Génome et Environnement CHU Clermont-Ferrand Université Clermont Auvergne Service Hygiène Hospitalière [CHU Clermont-Ferrand] CCLIN Sud-Est – Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est
• Publié dans HIV Medicine le 26/10/2020

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Résumé : Objectives: Our aim was to assess if switching from a protease inhibitors (PI)-based regimen to a PI-free one is associated with an increased risk of Kaposi Sarcoma (KS) relapse among patients living with HIV (PLHIV) with history of KS and controlled HIV replication. Methods: In a retrospective analysis of the prospectively collected Dat'AIDS database we selected patients who both had a past KS history and a HIV-1 viral load below 200 copies/mL while being PI-treated. We searched for KS relapses while persistent virological success was maintained for at least 6 months, whether patients kept taking the PI, or switched to PI-free regimen. Results: Among the 216 patients with past KS event and a history of HIV-1 infection efficiently treated by a PI-based regimen, 148 patients (68.5%) later switched to a PI-sparing regimen. Their baseline characteristics were not different from non-switching patients. We described 7 cases of relapse (3.2% of the 216 patients). Five cases of relapse occurred in switching patients (3.4%). The remaining two relapses occurred in PI-treated patients (2.9%). At KS relapse, CD4 cell count was 459 cells/μL (range 225-560) for switching patients, compared with 362 and 136 cells/μL for the other two patients. Conclusions: In this large cohort of PLHIV with a history of KS and ART-controlled HIV replication, KS relapses were described in 3.2% of the patients, and were not more frequent when a PI-containing ART regimen has been switched to a PI-free regimen. Our results do not support a specific effect of PI on KS.

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Fichiers liés : HIVMedicine_2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/02/2022
• Auteurs : Chris WymantDaniela BezemerFrançois BlanquartLuca FerrettiAstrid GallMatthew HallTanya GolubchikMargreet BakkerSwee Hoe OngLele ZhaoDavid BonsallMariateresa de CesareGeorge Macintyre-CockettLucie Abeler-DörnerJan AlbertNorbert BannertJacques FellayMary Kate GrabowskiBarbara Gunsenheimer-BartmeyerHuldrych GünthardPia KiveläRoger KouyosOliver LaeyendeckerLaurence MeyerKholoud PorterMatti RistolaArd van SighemBen BerkhoutPaul KellamMarion CornelissenPeter ReissChristophe FraserV. AubertM. BattegayE. BernasconiJ. BöniD. BraunH. BucherC. Burton-JeangrosA. CalmyM. CavassiniG. DollenmaierM. EggerL. ElziJ. FehrJ. FellayH. FurrerC. FuxM. GorgievskiH. GünthardD. HaerryB. HasseH. HirschM. HoffmannI. HösliC. KahlertL. KaiserO. KeiserT. KlimkaitR. KouyosH. KovariB. LedergerberG. MartinettiB. Martinez de TejadaC. MarzoliniK. MetznerN. MüllerD. NadalD. NiccaG. PantaleoA. RauchS. RegenassC. RudinF. Schöni-AffolterP. SchmidR. SpeckM. StöckleP. TarrA. TrkolaP. VernazzaR. WeberS. YerlyM. van der ValkS. GeerlingsA. GoorhuisJ. HoviusB. LempkesF. NellenT. van der PollJ. PrinsP. ReissM. van VugtW. WiersingaF. WitM. van DuinenJ. van EdenA. HazenbergA. van HesF. PijnappelS. SmalhoutA. WeijsenfeldS. JurriaansN. BackH. ZaaijerB. BerkhoutM. CornelissenC. SchinkelK. WolthersE. PetersM. van AgtmaelR. AutarM. BomersK. SigaloffM. HeitmullerL. LaanC. AngR. van HoudtM. JongesT. KuijpersD. PajkrtH. ScherpbierC. de BoerA. van der PlasM. van den BergeA. StegemanS. BaasL. Hage de LooffA. BuitingA. ReuwerJ. VeenemansB. WintermansM. PronkH. AmmerlaanD. van den BersselaarE. de MunnikB. DeimanA. JanszV. ScharnhorstJ. TjhieM. WegdamA. van EedenJ. NellenW. BrokkingL. ElsenburgH. NobelM. van KasterenM. BerrevoetsA. BrouwerA. AdamsR. van ErveB. de Kruijf-van de WielS. Keelan-PhafB. van de VenB. van der VenA. BuitingJ. MurckT. de Vries-SluijsH. BaxE. van GorpN. de Jong-PeltenburgM. de Mendonç̧a MeloE. van NoodJ. NouwenB. RijndersC. RokxC. SchurinkL. SlobbeA. VerbonN. BassantJ. van BeekM. VriesdeL. van ZonneveldJ. de GrootC. BoucherM. KoopmansJ. van KampenP. FraaijA. van RossumC. VermontL. van der KnaapE. VisserJ. BrangerR. DoumaA. Cents-BosmaC. Duijf-van de VenE. SchippersC. van NieuwkoopJ. van IjperenJ. GeilingsG. van der HutN. van BurgelE. LeytenL. GelinckF. MollemaS. Davids-VeldhuisC. TearnoG. WildenbeestE. HeikensP. GroeneveldJ. BouwhuisA. LammersS. KraanA. van HulzenM. KruiperG. van der BliekP. BorS. DebastG. WagenvoortF. KroonM. de BoerH. JolinkM. LambregtsA. RoukensH. ScheperW. DoramaN. van HoltenE. ClaasE. WesselsJ. den HollanderR. El MoussaouiK. PoganyC. BrouwerJ. SmitD. Struik-KalkmanT. van NiekerkO. PontesilliS. LoweA. Oude LashofD. PosthouwerM. van WolfswinkelR. AckensK. BurgersJ. SchippersB. Weijenberg-MaesI. van LooT. HavenithM. van VonderenL. KampschreurS. FaberR. Steeman-BoumaA. Al MoujahidG. KootstraC. DelsingM. van der Burg-van de PlasL. ScheiberlichW. KortmannG. van TwillertR. RenckensD. Ruiter-PronkF. van Truijen-OudJ. Cohen StuartEr. JansenM. HoogewerfW. RozemeijerW. van der ReijdenJ. SinnigeK. BrinkmanG. van den BerkW. BlokK. LettingaM. de RegtW. SchoutenJ. StalenhoefJ. VeenstraS. VrouenraetsH. BlaauwG. GeerdersM. KleeneM. KokM. KnapenI. van der MechéE. Mulder-SeelemanA. ToonenS. WijnandsE. WttewaalD. KwaR. van CrevelK. van AerdeA. DofferhoffS. HenrietH. ter HofstedeJ. HoogerwerfM. KeuterO. RichelM. AlbersK. Grintjes-HuismanM. de HaanM. MarneefR. Strik-AlbersJ. Rahamat-LangendoenF. StelmaD. BurgerE. GisolfR. HassingM. ClaassenG. ter BeestP. van BentumN. LangebeekR. TiemessenC. SwaninkS. van LelyveldR. SoetekouwL. van der PrijtJ. van der SwaluwN. BermonW. van der ReijdenR. JansenB. HerpersD. VeenendaalD. VerhagenF. LauwM. van BroekhuizenM. van WijkW. BiermanM. BakkerJ. KleinnijenhuisE. KloezeA. MiddelD. PostmaE. SchölvinckY. StienstraA. VerhageM. Wouthuyzen-BakkerA. BoonstraH. de Groot-de JongeP. van der MeulenD. de WeerdH. NiestersC. van Leer-ButerM. KnoesterA. HoepelmanJ. ArendsR. BarthA. BrunsP. EllerbroekT. MudrikovaJ. OosterheertE. SchaddB. van WelzenK. AarsmanB. Griffioen-van SantenI. de KroonM. van BerkelC. van RooijenR. SchuurmanF. Verduyn-LunelA. WensingL. BontS. GeelenY. LoeffenT. WolfsN. NautaE. RooijakkersH. HoltsemaR. VoigtD. van de WeteringA. AlbertoI. van der MeerA. RosinghT. HalabyS. ZaheriA. BoydD. BezemerA. van SighemC. SmitM. HillebregtA. de JongT. WoudstraD. BergsmaR. MeijeringL. van de SandeT. RutkensS. van der VlietL. de GrootM. van den AkkerY. BakkerA. El BerkaouiM. BezemerN. BrétinE. DjoechroM. GrotersE. KruijneK. LeliveltC. LodewijkE. LucasL. MunjishviliF. PalingB. PeeckC. ReeR. RegtopY. RuijsM. SchoorlP. SchnörrA. ScheigrondE. TuijnL. VeenenbergK. VisserE. WitteY. 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KennedyJ. PritchardU. AndradyN. RajdaC. DonnellyS. MckernanS. DrakeG. GilleranD. WhiteJ. RossJ. HardingR. FavilleJ. SweeneyP. FleggS. ToomerH. WildingR. WoodwardG. DeanC. RichardsonN. PerryM. GompelsL. JenningsD. BansaalM. BrowingL. ConnollyB. StanleyS. EstreichA. MagdyC. O’mahonyP. FraserS. JebakumarL. DavidR. MetteH. SummerfieldM. EvansC. WhiteR. RobertsonC. LeanS. MorrisA. WinterS. FaulknerB. GoorneyL. HowardI. FairleyC. StempL. ShortM. GomezF. YoungM. RobertsS. GreenK. SivakumarJ. MintonA. SiminoniJ. CalderwoodD. GreenhoughC. DesouzaLisa MuthernC. OrkinS. MurphyM. TruvediK. McleanD. HawkinsC. HiggsA. MoyesS. AntonucciS. MccormackW. LynnM. BevanJ. FoxA. TeagueJ. AndersonS. MguniF. PostL. CampbellC. MazhudeH. RussellR. GilsonG. CarrickJ. AinsworthA. WatersP. ByrneM. JohnsonS. FidlerK. KuldanekS. MullaneyV. LawlorR. MelvilleA. SukthankarS. ThorpeC. MurphyE. WilkinsS. AhmadP. GreenS. TayalElodie OngJ. MeadenL. RiddellD. LoayK. PeacockH. BlackmanV. HarindraA. SaeedS. AllenU. NatarajanO. WilliamsH. LaceyC. CareC. BowmanS. HermanS. DevendraJ. WitherA. BridgwoodG. SinghS. BushbyD. KellockS. YoungG. RooneyB. SnartJ. CurrieM. FitzgeraldJ. ArumainayyagamS. ChandramaniS. RajamanoharanT. RobinsonB. TaylorC. BrewerChristoph MayrWolfgang SchmidtAndrea SpeidelFrank StrohbachKeikawus ArastéhChristiane CordesManfred StündelJörg ClausAxel BaumgartenAndreas CarganicoPatrick IngilizStephan DupkeMatthias FreiwaldMichael RauschArend MollDorothea SchleehaufBettina HintscheGerd KlausenHeiko JessenArne JessenSiegfried KöppePeter KreckelDietmar SchranzKlaus FischerHubert SchulbinMiriam SpeerTobias GlaunsingerThomas WickeBernhard BieniekHeribert HillenbrandFrank SchloteElke Lauenroth-MaiChristoph SchulerDirk SchürmannHans WesselmannNorbert BrockmeyerPeter GehringDirk SchmalöerMartin HowerPetra Spornraft-RagallerDieter HäussingerStefan ReuterStefan EsserRudolf MarkusBurkhard KreftDirk BerzowAndreas ChristlAndreas MeyerAndreas PlettenbergAlbrecht StoehrKatrin GraefeThore LorenzenAxel AdamKnut ScheweLutwin WeitnerStefan FenskeStefan HansenHans-Jürgen StellbrinkDorothea WiemerSandra HertlingReinhold SchmidtPeter ArbterBernd ClausPeter GalleHans JägerEva Jä̈gel-GuedesNils PostelMonika FröschlChristoph SpinnerJohannes BognerBernd SalzbergerJürgen SchölmerichFranz AudebertTies MarquardtAndreas SchaffertEiko SchnaitmannAndreas TreinBernhard FrietschMarcus MüllerAlbrecht UlmerBarbara Detering-HübnerPeter KernFranz SchubertGünther DehnMaria SchreiberCengiz GülerBarbara Gunsenheimer-BartmeyerDaniel SchmidtKarolin MeixenbergerNorbert Bannert
• Organismes : Big Data Institute Stichting HIV Monitoring, Amsterdam Centre interdisciplinaire de recherche en biologie Infection, Anti-microbiens, Modélisation, Evolution Big Data Institute European Bioinformatics Institute [Hinxton] Big Data Institute Big Data Institute Amsterdam University Medical Centers The Wellcome Trust Sanger Institute [Cambridge] Big Data Institute Big Data Institute Nuffield Department of Clinical Medicine [Oxford] Nuffield Department of Clinical Medicine [Oxford] Big Data Institute Nuffield Department of Clinical Medicine [Oxford] Big Data Institute Karolinska Institutet [Stockholm] Karolinska University Hospital [Stockholm] Robert Koch Institute [Berlin] Ecole Polytechnique Fédérale de Lausanne Swiss Institute of Bioinformatics [Basel] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Université de Lausanne = University of Lausanne Johns Hopkins University [Baltimore] Robert Koch Institute [Berlin] University hospital of Zurich [Zurich] Universität Zürich [Zürich] = University of Zurich Helsinki University Hospital [Finland] University hospital of Zurich [Zurich] Universität Zürich [Zürich] = University of Zurich Centre de recherche en épidémiologie et santé des populations Helsinki University Hospital [Finland] Stichting HIV Monitoring, Amsterdam Amsterdam University Medical Centers Stichting HIV Monitoring, Amsterdam Big Data Institute Nuffield Department of Clinical Medicine [Oxford] Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Publié dans Science le 22/10/2020

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Résumé : We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.

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Fichiers liés : Lineage Effect Paper_V12_WithFigures.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/02/2022
• Auteurs : Florent SalvadorLaure DeramoudtFrédéric LeprêtreMartin FigeacThomas GuerrierJulie BoucherMathilde BasNathalie JourniacA. PetersLennart MarsHélène Zéphir
• Organismes : Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Genomic @ Lille - PLBS Genomic @ Lille - PLBS Lille Inflammation Research International Center - U 995 Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Lille Neurosciences & Cognition - U 1172 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Frontiers in Immunology le 25/10/2020

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Résumé : The key role of B cells in the pathophysiology of multiple sclerosis (MS) is supported by the presence of oligoclonal bands in the cerebrospinal fluid, by the association of meningeal ectopic B cell follicles with demyelination, axonal loss and reduction of astrocytes, as well as by the high efficacy of B lymphocyte depletion in controlling inflammatory parameters of MS. Here, we use a spontaneous model of experimental autoimmune encephalomyelitis (EAE) to study the clonality of the B cell response targeting myelin oligodendrocyte glycoprotein (MOG). In particular, 94% of SJL/j mice expressing an I-As: MOG92-106 specific transgenic T cell receptor (TCR1640) spontaneously develop a chronic paralytic EAE between the age of 60-500 days. The immune response is triggered by the microbiota in the gut-associated lymphoid tissue, while there is evidence that the maturation of the autoimmune demyelinating response might occur in the cervical lymph nodes owing to local brain drainage. Using MOG-protein-tetramers we tracked the autoantigen-specific B cells and localized their enrichment to the cervical lymph nodes and among the brain immune infiltrate. MOG-specific IgG1 antibodies were detected in the serum of diseased TCR1640 mice and proved pathogenic upon adoptive transfer into disease-prone recipients. The ontogeny of the MOG-specific humoral response preceded disease onset coherent with their contribution to EAE initiation. This humoral response was, however, not sufficient for disease induction as MOG-antibodies could be detected at the age of 69 days in a model with an average age of onset of 197 days. To assess the MOG-specific B cell repertoire we FACS-sorted MOG-tetramer binding cells and clonally expand them in vitro to sequence the paratopes of the IgG heavy chain and kappa light chains. Despite the fragility of clonally expanding MOG-tetramer binding effector B cells, our results indicate the selection of a common CDR-3 clonotype among the Igk light chains derived from both disease-free and diseased TCR1640 mice. Our study demonstrates the pre-clinical mobilization of the MOG-specific B cell response within the brain-draining cervical lymph nodes, and reiterates that MOG antibodies are a poor biomarker of disease onset and progression.

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Fichiers liés : fimmu-13-755900.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/01/2022
• Auteurs : Myles AllenGlen PetersKeith P ShineChristian AzarPaul BalcombeOlivier BoucherMichelle CainPhilippe CiaisWilliam J. CollinsPiers M ForsterDave J FramePierre FriedlingsteinClaire FysonThomas GasserBill HareStuart JenkinsSteven P HamburgDaniel J A JohanssonJohn LynchAdrian MaceyJohannes MorfeldtAlexander NauelsIlissa OckoMichael OppenheimerStephen W PacalaRaymond PierrehumbertJoeri RogeljMichiel SchaefferCarl F SchleussnerDrew ShindellRagnhild Bieltvedt SkeieStephen M SmithKatsumasa Tanaka
• Organismes : School of Geography and the Environment [Oxford] Center for International Climate and Environmental Research [Oslo] Department of Meteorology [Reading] Chalmers University of Technology [Göteborg] Queen Mary University of London Institut Pierre-Simon-Laplace Cranfield University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] University of Reading University of Leeds Victoria University of Wellington University of Exeter Climate Analytics International Institute for Applied Systems Analysis [Laxenburg] Climate Analytics University of Oxford Environmental Defense Fund Chalmers University of Technology [Göteborg] University of Oxford Victoria University of Wellington Chalmers University of Technology [Göteborg] Climate Analytics Environmental Defense Fund Princeton University Princeton University University of Oxford Imperial College London Climate Analytics Climate Analytics Duke University [Durham] Center for International Climate and Environmental Research [Oslo] University of Oxford Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation du climat
• Publié dans npj climate and atmospheric science le 21/06/2019

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Résumé : As researchers who have published over recent years on the issue of comparing the climate effects of different greenhouse gases, we would like to highlight a simple innovation that would enhance the transparency of stocktakes of progress towards achieving any multi-decade-timescale global temperature goal. In addition to specifying targets for total CO 2-equivalent emissions of all greenhouse gases, governments and corporations could also indicate the separate contribution to these totals from greenhouse gases with lifetimes around 100 years or longer, notably CO 2 and nitrous oxide, and the contribution from Short-Lived Climate Forcers (SLCFs), notably methane and some hydrofluorocarbons. This separate indication would support an objective assessment of the implications of aggregated emission targets for global temperature, in alignment with the UNFCCC Parties' Decision (4/ CMA.1) 1 to provide "information necessary for clarity, transparency and understanding" in nationally determined contributions (NDCs) and long-term low-emission development strategies (LT-LEDSs). While differences remain between us regarding how best to set fair yet ambitious targets for individual emitters 2-5 , including how any additional information might be used, and the interpretation of the Paris Agreement, it is important to emphasise the high level of agreement on the underlying science of how different greenhouse gases affect global temperature. The 2018 IPCC Special Report on 1.5 °C (SR1.5) 6 stated "Reaching and sustaining net-zero global anthropogenic CO 2 emissions and declining net non-CO 2 radiative forcing (Planetary energy imbalance resulting directly from human-induced changes.) would halt anthropogenic global warming on multi-decadal timescales (high confidence). The maximum temperature reached is then determined by cumulative net global anthropogenic CO 2 emissions up to the time of net zero CO 2 emissions (high confidence) and the level of non-CO 2 radiative forcing in the decades prior to the time that maximum temperatures are reached (medium confidence)". The IPCC 6th Assessment Report (AR6) 7 confirmed "limiting human-induced global warming to a specific level requires limiting cumulative CO 2 emissions, reaching at least net zero CO 2 emissions, along with strong reductions in other greenhouse gas emissions". Parties to the Paris Agreement agreed in Katowice in 2018 (Decision 18/CMA.1) 1 to report past emissions of individual gases separately and use 100-year Global Warming Potentials (GWP 100

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Fichiers liés : s41612-021-00226-2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2022
• Auteurs : Axel BenhamedAmina NdiayeMarcel EmondThomas LieutaudValérie BoucherAmaury GossiomeBernard LaumonBlandine GadegbekuKarim Tazarourte
• Organismes : Centre Hospitalier Lyon Sud [CHU - HCL] Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement CHU de Québec–Université Laval Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement CHU de Québec–Université Laval Centre Hospitalier Lyon Sud [CHU - HCL] Département Transport, Santé, Sécurité Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement Centre Hospitalier Lyon Sud [CHU - HCL]
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Background Thoracic trauma is a major cause of death in trauma patients and road traffic accident (RTA)-related thoracic injuries have different characteristics than those with non-RTA related thoracic traumas, but this have been poorly described. The main objective was to investigate the epidemiology, injury pattern and outcome of patients suffering a significant RTA-related thoracic injury. Secondary objective was to investigate the influence of serious thoracic injuries on mortality, compared to other serious injuries. Methods We performed a multicenter observational study including patients of the Rhône RTA registry between 1997 and 2016 sustaining a moderate to lethal (Abbreviated Injury Scale, AIS?2) injury in any body region. A subgroup (AISThorax?2 group) included those with one or more AIS?2 thoracic injury. Descriptive statistics were performed for the main outcome and a multivariate logistic regression was computed for our secondary outcome. Results A total of 176,346 patients were included in the registry and 6,382 (3.6%) sustained a thoracic injury. Among those, median age [IQR] was 41 [25-58] years, and 68.9% were male. The highest incidence of thoracic injuries in female patients was in the 70-79 years age group, while this was observed in the 20-29 years age group among males. Most patients were car occupants (52.3%). Chest wall injuries were the most frequent thoracic injuries (62.1%), 52.4% of which were multiple rib fractures. Trauma brain injuries (TBI) were the most frequent concomitant injuries (29.1%). The frequency of MAISThorax = 2 injuries increased with age while that of MAISThorax = 3 injuries decreased. A total of 16.2% patients died. Serious (AIS?3) thoracic injuries (OR = 12.4, 95%CI [8.6;18.0]) were strongly associated with mortality but less than were TBI (OR = 27.9, 95%CI [21.3;36.7]). Conclusion Moderate to lethal RTA-related thoracic injuries were rare. Multiple ribs fractures, pulmonary contusions, and sternal fractures were the most frequent anatomical injuries. The incidence, injury pattern and mechanisms greatly vary across age groups.

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Fichiers liés : ris00002240.pdf

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