Anne Martin

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Erin Michelle BuchananSavannah C LewisBastien ParisPatrick S ForscherJeffrey PavlacicJulie BeshearsShira Meir DrexlerAmélie Gourdon-KanhukamwePeter MallikMiguel Alejandro A. SilanJeremy MillerHans I JzermanHannah MoshontzJennifer BeaudryJordan SuchowChristopher ChartierNicholas A ColesMohammadhasan SharifianAnna Louise TodsenCarmel A LevitanFlávio AzevedoNicole LegateBlake HellerAlexander RothmanCharles DorisonBrian GillKe WangVaughan ReesNancy GibbsAmit GoldenbergThuy-Vy Thi NguyenJames GrossGwenaêl KaminskiClaudia von BastianMariola Paruzel-CzachuraFarnaz MosannenzadehSoufian AzouagheAlexandre BranSusana Ruiz-FernándezAnabela Caetano SantosNiv ReggevJanis H ZickfeldHandan AkkasMyrto PantaziIvan RopovikMax KorbmacherPatrícia ArriagaBiljana GjoneskaLara WarmelinkSara AlvesGabriel Lins de Holanda CoelhoStefan StiegerVidar ScheiPaul HanelBarnabas SzasziMaksim FedotovJan AntfolkGabriela Mariana MarcuJana SchrötterJonas KunstSandra J GeigerAdeyemi AdetulaHalil Emre KocalarJulita KielińskaPavol KačmárAhmed BokkourOscar Galindo-CaballeroIkhlas DjamaiSara Johanna PöntinenBamikole Emmanuel AgesinTeodor JernsätherAnum UroojNikolay R RachevMaria Koptjevskaja-TammMurathan KurfalıIlse PitRanran LiSami ÇoksanDmitrii DubrovTamar Elise PaltrowGabriel BaníkTatiana KorobovaAnna StudzinskaXiaoming JiangJohn Jamir Benzon R. ArutaJáchym VintrFaith ChiuLada KaliskaJana BerkesselMurat TümerSara Morales IzquierdoChuan-Peng HuKevin VezirianAnna Dalla RosaOlga BialobrzeskaMartin VasilevJulia BeitnerOndřej KáchaBarbara ŽuroMinja WesterlundMina Nedelcheva-DatsovaAndrej FindorDajana KrupićMarta KowalAdrian Dahl AskelundRazieh PourafshariJasna Milošević ĐorđevićNadya-Daniela SchmidtEkaterina BaklanovaAnna SzalaIlya ZakharovMarek A VrankaKeiko IhayaCaterina GranoNicola CelliniMichał BiałekLisa Anton-BoicukIlker DalgarArca AdıgüzelJeroen VerharenPrincess Lovella Gonzales MaturanAngelos KassianosRaquel OliveiraMartin ČadekVera Cubela AdoricAsil Ali ÖzdoğruTherese SverdrupBalazs AczelDanilo ZambranoAfroja AhmedChristian TamnesYuki YamadaLeonhard VolzNaoyuki SunamiLilian SuterLuc VieiraAgata Groyecka-BernardJulia Arhondis KamburidisUlf-Dietrich ReipsMikayel HarutyunyanGabriel Agboola AdetulaTara Bulut AllredKrystian BarzykowskiBenedict AntazoAndras ZsidoDušana Dušan ŠakanWilson Cyrus-LaiLina Pernilla AhlgrenMatej HruškaDiego VegaEfisio ManuntaAviv MokadyMariagrazia CapizziMarcel MartončikNicolas SayKatarzyna FilipRoosevelt VilarKarolina StaniaszekMilica VdovicMatúš AdamkovičNiklas JohannesNandor HajduNoga CohenClara OverkottDino KrupićBarbora HubenaGustav NilsonneGiovanna MioniClaudio Singh SolorzanoTatsunori IshiiZhang ChenElizaveta KushnirCemre KaraarslanRafael RibeiroAhmed KhaoudiMałgorzata KossowskaJozef BavolarKarlijn HoyerMarta RoczniewskaAlper KarababaMaja BeckerRenan MonteiroYoshihiko KunisatoIrem Metin-OrtaSylwia AdamusLuca KozmaGabriela CzarnekArtur DomuratEva ŠtrukeljDaniela Serrato AlvarezMichal ParzuchowskiSébastien MassoniJohanna Czamanski-CohenEkaterina ProniziusFany MuchembledKevin van SchieAslı SaçaklıEvgeniya HristovaAnna KuzminskaAbdelilah CharyateGijsbert BijlstraReza AfhamiNadyanna MajeedErica D MusserMiroslav SirotaRobert Malcolm RossSiu Kit YeungMarietta Papadatou-PastouFrancesco ForoniInês AlmeidaDmitry GrigoryevDavid LewisDawn Liu HolfordSteve M J JanssenSrinivasan TatachariCarlota BatresJonas K. OlofssonShimrit DachesAnabel BelausGerit PfuhlNadia Sarai Corral-FriasDaniela SousaJan Philipp RöerPeder Mortvedt IsagerHendrik GodbersenRadoslaw WalczakNatalia van DorenDongning RenTripat GillMartin VoracekLisa Marie DebruineMichele AnneSanja Batić OčovajAndrew ThomasAlexios ArvanitisThomas OstermannKelly WolfeNwadiogo Chisom ArinzeCarsten BundtClaus LammRobert Calin-JagemanWilliam DavisMaria KareklaSaša ZorjanLisa JaremkaJim UttleyMonika HricovaMonica A KoehnNatalia KiselnikovaHui BaiAnthony James KrafnickBusra Bahar BalciTonia BallantyneSamuel LinsZahir VallyCelia Esteban-SernaKathleen SchmidtPaulo Manuel L. MacapagalPaulina SzwedPrzemysław Marcin ZdybekDavid MoreauW. Matthew CollinsJennifer Joy-GabaIris VilaresUlrich TranJordane BoudesseulNihan Albayrak-AydemirBarnaby James Wyld DixsonJennifer PerilloAna FerreiraErin WestgateChristopher AbersonAzuka Ikechukwu ArinzeBastian JaegerMuhammad Mussaffa ButtJaime SilvaDaniel Shafik StorageAllison JanakWilliam Jiménez-LealJose SotoAgnieszka SorokowskaRandy McCarthyAlexa TullettMartha Frias-ArmentaMatheus Fernando Felix RibeiroAndree HartantoPaul ForbesMegan L WillisMaría del Carmen Tejada RAdriana Julieth Olaya TorresIan David StephenDavid VaidisAnabel de la Rosa-GómezKaren YuClare SutherlandMathi ManavalanBehzad BehzadniaJan UrbanErnest BaskinJoseph McfallChisom Esther OgbonnayaCynthia FuRima-Maria RahalIzuchukwu NdukaiheThomas HostlerHeather Barry KappesPiotr SorokowskiMeetu KhoslaLjiljana LazarevicLuis EudaveJohannes VilsmeierElkin LuisRafał MudaElena AgadullinaRodrigo CárcamoCrystal ReeckGulnaz AnjumMónica Camila Toro VenegasMichal MisiakRichard RyanNora NockGiovanni TravaglinoMichael MensinkGilad FeldmanAaron WichmanWeilun ChouIgnazio ZianoMartin SeehuusWilliam J ChopikFranki KungJoelle CarpentierLeigh Ann VaughnHongfei DuQinyu XiaoTiago LimaChris NooneSandersan OnieFrederick VerbruggenTheda RadtkeMaximilian Primbs
• Organismes : Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social Rhur University of Bochum Kingston University [London] King‘s College London Institute for Globally Distributed Open Research and Education Naturalis Biodiversity Center [Leiden] Laboratoire Inter-universitaire de Psychologie : Personnalité, Cognition, Changement Social University of Wisconsin-Madison University of Tehran School of Psychology and Neuroscience [University of St. Andrews] Bureau d'Économie Théorique et Appliquée
• Publié dans Scientific Data le 29/10/2020

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Résumé : In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data.

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Fichiers liés : s41597-022-01811-7-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : ikram MADANIJean-Benoît PeltierMartin BoeglinHervé SentenacAnne-Aliénor Véry
• Organismes : Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier
• Publié dans Stress Biology le 05/09/2022

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Résumé : Abstract The availability in the soil of potassium (K + ), a poorly mobile macronutrient required in large quantities for plant growth, is generally suboptimal for crop production in the absence of fertilization, making improvement of the ability of crops to adapt to K + deficiency stress a major issue. Increasing the uptake capacity of the root system is among the main strategies to achieve this goal. Here, we report an integrative approach to examine the effect of K + deficiency on the development of young plant entire root system, including root hairs which are known to provide a significant contribution to the uptake of poorly mobile nutrients such as K + , in two genetically distant wheat varieties. A rhizobox-type methodology was developed to obtain highly-resolved images of root and root hairs, allowing to describe global root and root hair traits over the whole root system via image analysis procedures. The two wheat varieties responded differently to the K + shortage: Escandia, a wheat ancestor, reduced shoot biomass in condition of K + shortage and substantially increased the surface area of its root system, specifically by increasing the total root hair area. Oued Zenati, a landrace, conversely appeared unresponsive to the K + shortage but was shown to constitutively express, independently of the external K + availability, favorable traits to cope with reduced K + availability, among which a high total root hair area. Thus, valuable information on root system adaptation to K + deficiency was provided by global analyses including root hairs, which should also be relevant for other nutrient stresses.

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Fichiers liés : MadaniI.-et al-StressBiol-2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Khalil ChaïbiFranck EhoomanBertrand PonsLaurent Martin-LefevreEric BouletAlexandre BoyerGuillaume ChevrelNicolas LerolleDorothée CarpentierNicolas de ProstAlexandre LautretteAnne BretagnolJulien MayauxSaad NseirBruno MegarbaneMarina ThirionJean-Marie ForelJulien MaizelHodane YonisPhilippe MarkowiczGuillaume ThieryFrédérique SchortgenCécile CouchoudDidier DreyfussStéphane Gaudry
• Organismes : Hôpital Avicenne [AP-HP] Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée CHU Pointe-à-Pitre/Abymes [Guadeloupe] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier René Dubos [Pontoise] Hôpital Pellegrin Centre Hospitalier Sud Francilien Centre Hospitalier Universitaire d'Angers CHU Rouen CHU Henri Mondor [Créteil] Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) CHU Gabriel Montpied [Clermont-Ferrand] Centre Hospitalier Régional d'Orléans CHU Pitié-Salpêtrière [AP-HP] CHU Lille Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Lariboisière-Fernand-Widal [APHP] Centre Hospitalier Victor Dupouy Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] CHU Amiens-Picardie Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 Hôpital de la Croix-Rousse [CHU - HCL] Centre Hospitalier de Cholet Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Intercommunal de Créteil Registre REIN Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Hôpital Louis Mourier - AP-HP [Colombes] Université Paris Cité Hôpital Avicenne [AP-HP] Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background The extent of the consequences of an episode of severe acute kidney injury (AKI) on long-term outcome of critically ill patients remain debated. We conducted a prospective follow-up of patients included in a large multicenter clinical trial of renal replacement therapy (RRT) initiation strategy during severe AKI (the Artificial Kidney Initiation in Kidney Injury, AKIKI) to investigate long-term survival, renal outcome and health related quality of life (HRQOL). We also assessed the influence of RRT initiation strategy on these outcomes. Results Follow-up of patients extended from 60 days to a median of 3.35 years [interquartile range (IQR), 1.89 to 4.09] after the end of initial study. Of the 619 patients included in the AKIKI trial, 316 survived after 60 days. The overall survival rate at 3 years from inclusion was 39.4% (95% CI 35.4 to 43.4). A total of 46 patients (on the 175 with available data on long-term kidney function) experienced worsening of renal function (WRF) at the time of follow-up [overall incidence of 26%, cumulative incidence at 4 years: 20.6% (CI 95% 13.0 to 28.3)]. Fifteen patients required chronic dialysis (5% of patients who survived after day 90). Among the 226 long-term survivors, 80 (35%) answered the EQ-5D questionnaire. The median index value reported was 0.67 (IQR 0.40 to 1.00) indicating a noticeable alteration of quality of life. Initiation strategy for RRT had no effect on any long-term outcome. Conclusion Severe AKI in critically ill patients was associated with a high proportion of death within the first 2 months but less so during long-term follow-up. A quarter of long-term survivors experienced a WRF and suffered from a noticeable impairment of quality of life. Renal replacement therapy initiation strategy was not associated with mortality outcome. Graphical Abstract

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Fichiers liés : s13613-023-01108-x.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Bernard CholleyMirela BojanBenoit GuillonEmmanuel BesnierMathieu MatteiBruno LevyAlexandre OuattaraNadir TaferClément DelmasDavid TononBertrand RozecJean-Luc FellahiPascal LimFrançois LabasteFrançois RoubilleThibaut CarubaPhilippe MauriatOlivier BarbotBerthomieu LaurentAnne-Marie BesselatBlanchart KatrienAdrien BouglePierre BourgoinCauseret ArnaudHélène CharbonneauMircea CristinarOlivier DesebbeVeldat EljeziThibaud GenetMaxime GrenierPierre Grégoire GuinotStéphane LebelYael LevyFrançois LionJacques MansouratiStéphanie MarlièreAnne-Céline MartinAlexandre MebazaaUsman MohammadJacques MonseguNicolas NesslerIsabelle OrselEtienne PuymiratMorgan RecherSabri SoussiVincent TroussardSabrina UhryXavier Zirphile
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied.

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Fichiers liés : 2023 Chollet et al., Overview of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Matthieu JabaudonAlexandra GenevrierSamir JaberOlivier WindischStéphanie BulyezPierre-François LaterreEtienne EscudierAchille SossouPhilippe GuerciPierre-Marie BertrandPierre-Eric DaninMartin BonnassieuxLeo BühlerClaudia Paula HeideggerRussell ChabanneThomas GodetLaurence RoszykVincent SapinEmmanuel FutierBruno PereiraJean-Michel ConstantinElodie CaumonJulien AmatDominique MorandRenaud GuérinSébastien PerbetBenjamin RieuSophie CayotChristian ChartierCamille VerlhacChristine RolhionJustine BourdierBernard CosserantRaiko BlondonnetJean-Baptiste JoffredoThomas CostillesDamien BouvierLise BernardJean-Etienne BazinLaurence RoszykLydie Marie-AnneRaphaël GiraudAnnick PuchoisCyril BoronadMarine AgulloBoris JungGérald ChanquesCécile SpiritoMarion MonninAlbert PradesMoussa CisseAnne VerchereClaudine GniadekFouad BelafiaDaniel VerzilliJulie CarrAudrey de JongYannael CoiselJean-Marc DelayMatthieu ConseilMarie GonzalezDelphine RosantMichel PrevotBernard ClaudFrançois BrenasLassane ZanrePhilippe BrayHélène RieraEmilie Gadea-DeschampsPablo MassanetCaroline BoutinSaber BarbarDavid-Paul de BrauwereSerge LumbrosoAmélie MaurinSophie LloretLaurent MullerClaire RogerJean-Yves LefrantLoubna ElotmaniAudrey AyralSuzanne RenardNadège BouskilaGaspard BeauneMagali Farines-RaffoulMarie LeboucAuguste DargentThomas CrozonJulien ClauzelMarinne Le CoreThomas Rimmelé
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in addition to usual care, in improving clinical outcomes of intensive care unit patients with acute pancreatitis. Methods A multicenter, open-label, randomized, controlled trial including adult patients with a clinical diagnosis of acute pancreatitis upon admission to the intensive care unit. Participants were randomly assigned (1:1) to a strategy combining thoracic epidural analgesia and usual care (intervention group) or a strategy of usual care alone (control group). The primary outcome was the number of ventilator-free days from randomization until day 30. Results Between June 2014 and January 2019, 148 patients were enrolled, and 135 patients were included in the intention-to-treat analysis, with 65 patients randomly assigned to the intervention group and 70 to the control group. The number of ventilator-free days did not differ significantly between the intervention and control groups (median [interquartile range], 30 days [15–30] and 30 days [18–30], respectively; median absolute difference of − 0.0 days, 95% CI − 3.3 to 3.3; p = 0.59). Epidural analgesia was significantly associated with longer duration of invasive ventilation (median [interquartile range], 14 days [5–28] versus 6 days [2–13], p = 0.02). Conclusions In a population of intensive care unit adults with acute pancreatitis and low requirement for intubation, this first multicenter randomized trial did not show the hypothesized benefit of epidural analgesia in addition to usual care. Safety of epidural analgesia in this setting requires further investigation. Trial registration : ClinicalTrials.gov registration number NCT02126332 , April 30, 2014.

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Fichiers liés : 2023 Jabaudon et al., Thoracic.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Marius TrøseidJosé ArribasLambert AssoumouAleksander Rygh HoltenJulien PoissyVida TerzićFulvia MazzaferriJesús Rodríguez BañoJoe EustaceMaya HitesMichael JoannidisJosé-Artur PaivaJean ReuterIsabel PüntmannThale Patrick-BrownElin WesterheimKaterina Nezvalova-HenriksenLydie BeniguelTuva Børresdatter DahlMaude BouscambertMonika HalanovaZoltán PéterfiSotirios TsiodrasMichael RezekMatthias BrielSerhat ÜnalMartin SchlegelFlorence AderKarine LacombeCecilie Delphin AmdalSerge RodriguesKristian TonbyAlexandre GaudetLars HeggelundJoy MootienAsgeir JohannessenJannicke Horjen MøllerBeatriz Diaz PollanAnders Aune TveitaAnders Benjamin KildalJean-Christophe RichardOlav DalgardVictoria Charlotte SimensenAliou BaldéLucie de GastinesMarta del ÁlamoBurç AydinFridtjof Lund-JohansenMary-Anne TrabaudAlpha DialloBente HalvorsenJohn-Arne RøttingenEvelina TacconelliYazdan YazdanpanahInge OlsenDominique CostagliolaAnne Ma Dyrhol-RiiseBirgitte StiksrudSynne JenumMagnhild Eide MacphersonNikolai Ravn AarskogKjerstin RøstadLinda Gail SkeieÅsne DahlJeanette Konstance SteenSarah NurFilip SegersKatrine Andersen KorsanAshwini SethupathyAnn Jorunn SandståGunn-Janne PaulsenThor UelandAnnika MichelsenPål AukrustJan Erik BerdalIngunn MelkeraaenMerete Moen TollefsenJessica AndreassenJannicke DokkenKarl Erik MüllerBjørn Martin WollHanne OpsandMette BogenLinn-Therese RødTrude SteinsvikBjørn Åsheim-HansenRandi Haukaas BjerkreimÅse BergSolfrid MoenStina KvalheimKristian StrandBerit GravrokVegard SkogenElias Myrvoll LorentzenSimen Walberg SchiveLasse RossvollHedda HoelSimon EngebråtenMia Schie MartinssonMonica ThallingerElise ÅdnanesRaisa HannulaNina BremnesKristin LiyanarachiBirgitta EhrnströmMartin KvalshaugKari BergeMarte BygdåsLinda GustafssonSaad AballibMarianne StrandBritt AndersenPål AukrustAndreas Barratt-DueKaterina Nezvalova HenriksenTrine KåsineAnne Ma Dyrhol-RiiseJan Erik BerdalRaphaël FavorySaad NseirSebastien PreauMercé JourdainGeoffrey LedouxArthur DurandMarion HouardAnne-Sophie MoreauAnahita RouzéRomain TortuyauxGuillaume DegouyClémentin LevyVincent LiuNicolas DognonLaure MarillerClaire DelcourteZineb ReguigAmélie CerfMarie CuvelliezEric KipnisMarielle Boyer-BeysserreAnne BignonLaurie ParmentierDamia MeddourSarah FradeJean-François TimsitNathan Peiffer-SmadjaPaul-Henri WickyEtienne de MontmollinLila BouadmaJulien DessajanRomain SonnevilleJuliette PatrierSimona PresenteZmihi SyliaChristophe RiouxMichaël ThyLio ColliasYasmine BouarabaNikita DobremelAnne-Florence DureauPierre OudevilleValentin PointurierYannick RabouelLaure StielCamille AlzinaCamille RamsteinHafid Ait-OufellaFatima HamoudiThomas UrbinaYoann ZerbibJulien MaizelCeline WilpotteLionel PirothMathieu BlotThibault SixtFlorian MorettoCarole CharlesSandrine GohierDamien RouxCamille Le BretonCoralie GernezIngrid ThiryLoredana BaboiDenis MalvyAlexandre BoyerPauline PerreauMaddalena ArmelliniGiulia de LucaOspedale Di PietroBenedetta RomaninMichela BrogiFrancesco CastelliSilvia AmadasiFrancesco BarchiesiBenedetta CanovariNicola CoppolaMariantonietta PisaturoAntonio RussoLaura OcchielloFrancesco CataldoMarta Mora RilloJavier QueirugaEnrique SecoStefan StewartAlberto BorobiaPaloma MoragaRocío PrietoIrene GarcíaCarlota RiveraJosé Luis NarroNatalia ChacónSandra de la RosaMaría MacíasLydia BarreraAlmudena SernaVirginia PalomoMaria Isabel García SánchezDavid GutiérrezAna Silva CamposMiguel Ángel Gómez GarfiaElvira Bonilla ToyosJudith Sanabria CabreraMaría Isabel LucenaEva Larranaga LapiquePierre EnglertZineb KhalilFrédérique JacobsJustine MalaiseOdette MukangenziCinderella SmissaertMarc HildebrandDelphine MartinyAudrey VervackeAxelle ScarnièreNicolas YinCharlotte MichelLucie SeylerSabine AllardJohan van LaethemGil VerscheldenAnnelies MeeuwissenAlex de WaeleVirgini van BuggenhoutDora MonteyneNils NoppeLeila BelkhirJean Cyr YombiJulien de GreefJean Baptiste MeslandLéopold de GhellinckValérie KinCéline D’aoustAnne BouvierAnne- Charlotte DekeisterEstelle HawiaAdeline GailletHélène DeshormeSeverine HalleuxVanessa GalandRoberto Roncon-AlbuquerqueLuís Linhares SantosCésar Burgi VieiraRosana MagalhaesSónia FerreiraMariana BernardoArthur JacksonCorinna SadlierSarah O’connellMatthew BlairEdmund ManningFiona CusackNiamh KellyHannah StephensonRuben KeaneAisling MurphyMichele CunnaneFionnuala KeaneMary-Claire O’reganEoghan de BarraAimee Mcgreal BelloneSiobhan O’reganPatrick CareyJeffrey HartePeter CoakleyAoife HeeneyDorothy RyanGerard CurleySamuel McconkeyImran SulaimanRichard CostelloCora McnallyClaire FoleySophie TrainorBenson JacobSuchitra VengathodiBrian KentColm BerginLiam TownsendColm KerrNalini PantiAlberto Garcia SanzBinny BennyEdel DeaNiamh GalvinClaire BurkeAisling GalvinSara AisiyabiDeepanjali LoboJohn LaffeyBairbre McnicolasDavid CosgraveJ. SheehanCiprian NitaCiara HanleyClaire KellyMaeve KernanJonathan MurrayThérèse StaubThomas HeninGaelle DamilotTania BintenerJoelle CollingChristian FerrettiChristophe WererPascal StammetPierre BraquetVic ArendtEsther CalvoChristian MichauxChouaib MediouniAli ZnatiGloria MontanesLaetitia GarciaClaudius ThoméRobert BreitkopfAndreas PeerGeorg LehnerRomuald BellmanAdelheid DitlbacherArmin FinkenstedtKlemens ZotterChristian Preuss HernandezSasa RajsicBarbara LanthalerRichard GreilKiss TamásSzilvia Kovácsné-LevangDavid SiposAgnes KappéterBernadett Halda-KissEdit Madarassi-PappEdit HajduBalázs BendeThomas KonstantinosCharalambos MoschopoulosEleni LabrouMaria TsakonaIoannis GrigoropoulosAnastasia KotanidouParaskevi FragkouMaria TheodorakopoulouEugenia PantaziEdison JahaiMaria MoukouliDimitrios SiafakasBernd MühlbauerRolf DembinskiKathrin StichGerhard SchneiderAndrej NagyKarolína GrodováMichaela KubelováLenka SoučkováHelena Kartáková ŠvábováRegina DemlováSimona SonderlichováSerhat UnalA. InkayaStephanie de BonoCynthia KartmanDavid AdamsBrenda CroweYazdan YazdanapanahSerhat UnalGerhard SchneiderBernd MühlbauerTone ØdegårdGine BakkehøiBrigitte AutranMagnar BjøråsXavier De- LambellerieFulvia MezzarriJeremie GuedjHelene EsperouJulia LumbrosoTobias WelteAlexandra CalmySøren PischkeShaun TreweekEls GoetghebeurAdelaide DoussauLaurence WeissFrank HulstaertRadu BotgrosMarta del AlamoFlorence ChungJulia LumbrosoMarkus ZeitlingerBegonya EscaleraChantal CsajkaClare WilliamsAlain AmstutzCorina Silvia RüeggCharles BurdetClement MassonnaudDrifa BelhadiFrance MentréMassinissa ArounFrance MentréStephan EhrmannHelene EspoerouCharles BurdetRagnhild Sørum FalkKristin BjordalGina BakkehøiTone ØdegårdAndreas Barratt-Due
• Organismes : Infection, Anti-microbiens, Modélisation, Evolution
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-controlled trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients with severe/critical COVID-19 were randomised to Baricitinib 4 mg once daily or placebo, added to standard of care. The primary endpoint was all-cause mortality within 60 days. Participants were remotely followed to day 90 for safety and patient related outcome measures. Results Two hundred ninety-nine patients were screened, 284 randomised, and 275 received study drug or placebo and were included in the modified intent-to-treat analyses (139 receiving baricitinib and 136 placebo). Median age was 60 (IQR 49–69) years, 77% were male and 35% had received at least one dose of SARS-CoV2 vaccine. There were 21 deaths at day 60 in each group, 15.1% in the baricitinib group and 15.4% in the placebo group (adjusted absolute difference and 95% CI − 0.1% [− 8·3 to 8·0]). In sensitivity analysis censoring observations after drug discontinuation or rescue therapy (tocilizumab/increased steroid dose), proportions of death were 5.8% versus 8.8% (− 3.2% [− 9.0 to 2.7]), respectively. There were 148 serious adverse events in 46 participants (33.1%) receiving baricitinib and 155 in 51 participants (37.5%) receiving placebo. In subgroup analyses, there was a potential interaction between vaccination status and treatment allocation on 60-day mortality. In a subsequent post hoc analysis there was a significant interaction between vaccination status and treatment allocation on the occurrence of serious adverse events, with more respiratory complications and severe infections in vaccinated participants treated with baricitinib. Vaccinated participants were on average 11 years older, with more comorbidities. Conclusion This clinical trial was prematurely stopped for external evidence and therefore underpowered to conclude on a potential survival benefit of baricitinib in severe/critical COVID-19. We observed a possible safety signal in vaccinated participants, who were older with more comorbidities. Although based on a post-hoc analysis, these findings warrant further investigation in other trials and real-world studies. Trial registration Bari-SolidAct is registered at NCT04891133 (registered May 18, 2021) and EUClinicalTrials.eu ( 2022-500385-99-00 ).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El 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BuenoHuda BukhariJacinta BustamanteJuan José Cáceres AgraRuggero CapraRaphael CarapitoMaria CarrabbaCarlos CasasnovasMarion CaserisIrene CassanitiMartin CastelleFrancesco CastelliMartín Castillo de VeraMateus CastroEmilie CatherinotJale Bengi CelikAlessandro CeschiMartin ChalumeauBruno CharbitMatthew ChengPère ClavéBonaventura ClotetAnna CodinaYves CohenCloé ComarmondAlain CombesPatrizia ComoliAngelo CorsicoBetul SozeriTaner CoşkunerAleksandar CvetkovskiCyril CyrusDavid DalmauFrançois DanionDavid Ross DarleyVincent DasNicolas DaubyStéphane DaugerPaul de MunterLoic de PontualAmin DehbanGeoffroy DelplancqAlexandre DemouleIsabelle DesguerreAntonio Di SabatinoJean-Luc DiehlStephanie DobbelaereElena Domínguez-GarridoClément DubostOlov EkwallŞefika Elmas BozdemirMarwa ElnagdyMelike EmirogluAkifumi EndoEmine Hafize ErdenizSelma Erol AytekinMaria Pilar Etxart LasaRomain EuvrardGiovanna FabioLaurence FaivreAntonin FalckMuriel FartoukhMorgane FaureMiguel Fernandez ArqueroRicard FerrerJose FerreresBruno FrancoisVictoria FumadóKitty FungFrancesca FuscoAlenka GagroBlanca Garcia SolisPierre GarçonPascale GaussemZeynep GayretliJuana Gil-HerreraLaurent GilardinAudrey Giraud GatineauMònica Girona-AlarcónKaren Alejandra Cifuentes GodínezJean-Christophe GoffardNacho GonzalesLuis Gonzalez-GranadoRafaela González-MontelongoAntoine GuerderBelgin GülhanVictor Daniel GumucioLeif Gunnar HanitschJan GunstJérôme HadjadjTetyana HariyanNevin HatipogluDeniz HeppekcanElisa Hernandez-BritoPo-Ki HoMaría Soledad Holanda-PeñaJuan HorcajadaSami HraiechLinda HumbertIvan HungAlejandro IglesiasAntonio Íñigo-CamposMatthieu JammeMaría Jesús ArranzMarie-Thérèse JimenoIolanda JordanSaliha Kanik-YüksekYalcin Burak KaraAydın KarahanKadriye Kart YasarOzgur KasapcopurKenichi KashimadaYasemin Kendir DemirkolYasutoshi KidoCan KizilAhmet Osman KılıçAdam KlocperkAntonia KoutsoukouZbigniew KrólHatem KsouriPaul KuentzArthur KwanYat Wah M. KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnes LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalSébastien VielCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessio FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie Cobat
• Organismes : Nutrition et obésités: approches systémiques (UMR-S 1269)
• Publié dans Genome Medicine le 24/10/2020

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Résumé : Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7 , with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10 −4 ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10 −4 ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10 −3 ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10 −8 ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 −5 ). Conclusions Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Sammy BadrAnne CottenRomuald MentaverriDaniela LombardoJulien LabreucheClaire MartinLucie HénautBernard CortetJulien Paccou
• Organismes : Neurobiologie des processus adaptatifs CHU Amiens-Picardie Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 Unité de Taphonomie médico-légale et Anatomie - ULR 7367 CHU Lille Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 University of Lille Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490
• Publié dans Bone Reports le 06/07/2018

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Résumé : Introduction Bone marrow adipose tissue (BMAT) is associated with aging, osteoporosis, and chronic kidney disease (CKD). To date, the association between BMAT and kidney function in postmenopausal women has not been thoroughly investigated. The main purpose of this study was to determine whether a relationship exists between proton density fat fraction (PDFF) and kidney function in postmenopausal women. Methods We investigated the cross-sectional association between estimated glomerular filtration rate (eGFR) – calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation – and PDFF – measured at the lumbar spine and proximal femur using Water Fat Imaging (WFI) MRI – in 199 postmenopausal women from the ADIMOS cohort study. We also performed DXA scans and laboratory measurements of sclerostin and c-terminal Fibroblast Growth Factor 23 (cFGF23). Results Participants' mean age was 67.5 (standard deviation, SD 10.0) years. Their median eGFR was 85.0 (interquartile range, IQR 72.2–95.0) ml/min/1.73 cm2, and their mean lumbar spine PDFF was 57.9 % (SD 9.6). When classified by eGFR-based CKD stages, 41.7 % of the cohort had an eGFR ≥ 90 (n = 83), 47.2 % had an eGFR of 60–89.9 (n = 94), and 11.1 % had an eGFR of 30–59.9 (n = 22). Participants with eGFR ≥ 90 had a lower lumbar spine PDFF than those with eGFR 60–89.9 (mean 55.8 % (9.8) vs. 58.9 % (9.0), p = 0.031) and those with eGFR 30–59.9 (55.8 % (9.8) vs. 60.8 % (9.8), p = 0.043). However, the differences did not remain significant after adjusting for predetermined confounders, including age, diabetes, Charlson comorbidity index, recent history of fragility fracture, appendicular lean mass, and lumbar spine BMD. The inclusion of sclerostin and/or cFGF23 as suspected mediators did not alter the findings. When proximal hip imaging-based PDFF was considered, no significant differences were found between the eGFR categories in the unadjusted and adjusted analyses. Conclusion No evidence of an association between kidney function and bone marrow adiposity was found either in the lumbar spine or proximal femur in a cohort of postmenopausal women.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2023
• Auteurs : Sylvain MathieuC. LambertFrançoise FayetMarion CoudercMarine BeaugerSandrine MalochetMarie-Eva PickeringAnne TournadreMartin Soubrier
• Organismes : Imagerie Moléculaire et Stratégies Théranostiques
• Publié dans Rheumatology International le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2023
• Auteurs : Anaïs RusquetVincent FaminX. QuidelleurLaurent MichonFrançois NauretMartin DanišíkIsabelle ThinonSylvie LeroyAnne Lemoine
• Organismes : Institut de Physique du Globe de Paris Université Paris Cité Laboratoire GéoSciences Réunion Laboratoire GéoSciences Réunion Institut de Physique du Globe de Paris Université Paris-Saclay Géosciences Paris Saclay Laboratoire GéoSciences Réunion Institut de Physique du Globe de Paris Laboratoire Magmas et Volcans Curtin University [Perth] Bureau de Recherches Géologiques et Minières (BRGM) Institut des Sciences de la Terre de Paris Bureau de Recherches Géologiques et Minières (BRGM)
• Publié dans Journal of Volcanology and Geothermal Research le 27/10/2020

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Résumé : The volcanism of the Comoros archipelago (from west to east: Grande Comore, Mohéli, Anjouan, and Mayotte islands) has been under renewed scientific scrutiny since the eruption of a new submarine volcanic edifice (Fani Maoré) which begun in May 2018 east of Mayotte. West of Mayotte, Mohéli island has received little attention from the geoscience community, despite its largely uneroded volcanic landscapes suggesting a recent activity that has not been dated. Here we address this gap in knowledge by applying Ksingle bondAr geochronology on groundmass and major-trace element analyses to subaerial and submarine rocks, in an attempt to reconstruct the volcano-tectonic and geochemical evolution of Mohéli. Our results show that Mohéli's volcano-tectonic evolution proceeded in two constructional stages, including a primary edification along a N070°E axis from before ca. 3.8 Ma to ca. 3 Ma (Stage 1), and a second construction along a N110°E ridge shaping the present-day island since ca. 2 Ma (Stage 2). The two stages were separated by an increased subsidence (≥0.2 mm/yr) that drowned a large part of the N070°E primary edifice. The two identified volcano-tectonic stages are reflected also in the geochemical evolution of emitted magmas, which were moderately silica-undersaturated in Stage 1 and moderately to highly silica-undersaturated in Stage 2. Silica undersaturation increases with time up to the olivine melilitite field, together with enrichments in Ca, P, and incompatible trace elements, suggesting the increasing contribution of a metasomatized mantle in melts. The coeval changes of construction orientations and magmas compositions of Mohéli suggest a modification in the tectonics of the Comoros related to magmatism at about 2 Ma. The most recent volcanic morphology investigated is an olivine nephelinite lava flow on the north coast of the island dated at 8 ± 2 ka. This finding of Holocene volcanism on Mohéli implies that the entire Comoros archipelago should be considered as an active zone in any volcanic hazard assessment. The melilite-bearing rocks of Mohéli share geochemical similarities with those of Mayotte and of the Cenozoic volcanic provinces of Madagascar, further pointing to similar melting sources and magmatic processes over the Mozambique channel.

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