Anne Martin

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2015
• Auteurs : Anne BodlennerWenjun LiuGuillaume HirschP. SchaefferMartin BlumenbergRalf LendtDenis TritschWalter MichaelisMichel Rohmer
• Organismes : Laboratoire d'innovation moléculaire et applications Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg Institut de Chimie de Strasbourg
• Publié dans ChemBioChem le 29/10/2020

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Résumé : The major bacterial triterpenoids of the hopane series each consist of a C30 triterpene hopane moiety and an additional nonterpene C5 side chain derived from d-ribose and linked through its C-5 carbon atom to the hopane side chain. Bacteriohopanetetrol and aminobacteriohopanetriol are the most common representatives of this natural product series, adenosylhopane and ribosylhopane being putative precursors. Deuterium- labelled ribosylhopane was obtained by hemisynthesis and converted into deuterium-labelled bacteriohopanetetrol in the presence of NADPH, thus giving evidence of this as yet unknown precursor-to-product relationship in the bacterial hopanoid metabolic pathway.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/07/2015
• Auteurs : Guillaume DesprasAlsu I. ZamaleevaLucie DardevetCéline TisseyreJoao Gamelas MagalhaesCharlotte GarnerMichel de WaardSebastian AmigorenaAnne FeltzJean-Maurice MalletMayeul Collot
• Organismes : Université Pierre et Marie Curie - Paris 6 Institut de biologie de l'ENS Paris Immunité et cancer Institut National de la Santé et de la Recherche Médicale Université Joseph Fourier - Grenoble 1 Institut National de la Santé et de la Recherche Médicale Université Joseph Fourier - Grenoble 1 Smartox Biotechnology [Saint Martin d'Hères] Université Pierre et Marie Curie - Paris 6 Institut National de la Santé et de la Recherche Médicale Université Joseph Fourier - Grenoble 1 Smartox Biotechnology [Saint Martin d'Hères] Smartox Biotechnology [Saint Martin d'Hères] Institut de biologie de l'ENS Paris Université Pierre et Marie Curie - Paris 6 Université Pierre et Marie Curie - Paris 6
• Publié dans Chemical Science le 22/10/2020

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Résumé : Monitoring intracellular pH has drawn much attention due to its undeniably important function in cells. The widespread development of fluorescent imaging techniques makes pH sensitive fluorescent dyes valuable tools, especially red-emitting dyes which help to avoid the overcrowded green end of the spectral band. Herein, we present H-Rubies, a family of pH sensors based on a phenol moiety and a X-rhodamine fluorophore that display a bright red fluorescence upon acidification with pK a values spanning from 4 to 9. Slight structural modifications led to dramatic changes in their physicochemical properties and a relationship between their structures, their ability to form H-aggregates, and their apparent pK a was established. While molecular form H-Rubies can be used to monitor mitochondrial acidification of glioma cells, their functionalised forms were linked via click chemistry to dextrans or microbeads containing a near infrared Cy5 (Alexa-647) in order to provide ratiometric systems that were used to measure respectively the phagosomal and endosomal pH in macrophages (RAW 264.7 cells) using flow cytometry.

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Fichiers liés : Despras_2015_H-Rubies,_a_new.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2015
• Auteurs : Karim FizaziLaura FaivreFrançois LesaunierRemy DelvaGwenaelle GravisFrédéric RollandFrank PriouJean-Marc FerreroNadine HouédéLoïc MoureyChristine ThéodoreIvan KrakowskiJean-François BerdahMarjorie BaciuchkaBrigitte LaguerreAude FléchonAlain RavaudIsabelle Cojean-ZelekStéphane OudardJean-Luc LaboureyPaule Chinet-CharrotEric LegouffeJean-Léon LagrangeClaude LinassierGaël DeplanquePhilippe BeuzebocJean-Louis DavinAnne-Laure MartinMuriel HabibianAgnès LaplancheStéphane Culine
• Organismes : Institut Gustave Roussy Institut Gustave Roussy Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Paoli-Calmettes Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Hospitalier Universitaire de Nîmes Institut de Recherche en Cancérologie de Montpellier Institut Claudius Regaud Hôpital Foch [Suresnes] Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Hôpital privé Toulon Hyères : Sainte Marguerite Hôpital de la Timone [CHU - APHM] CRLCC Eugène Marquis Centre Léon Bérard [Lyon] Hôpital Saint-André Groupe Hospitalier Diaconesses Croix Saint-Simon Hôpital Européen Georges Pompidou [APHP] CHU Limoges Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen ONCOGARD - NIMES Hôpital Henri Mondor Centre Hospitalier Régional Universitaire de Tours Hôpital Saint-Joseph Institut Curie [Paris] Institut Sainte Catherine [Avignon] UNICANCER [Paris] UNICANCER [Paris] Institut Gustave Roussy Hôpital Saint-Louis
• Publié dans Lancet Oncology le 02/11/2020

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Résumé : BACKGROUND: Early risk-stratified chemotherapy is a standard treatment for breast, colorectal, and lung cancers, but not for high-risk localised prostate cancer. Combined docetaxel and estramustine improves survival in patients with castration-resistant prostate cancer. We assessed the effects of combined docetaxel and estramustine on relapse in patients with high-risk localised prostate cancer. METHODS: We did this randomised phase 3 trial at 26 hospitals in France. We enrolled patients with treatment-naive prostate cancer and at least one risk factor (ie, stage T3-T4 disease, Gleason score of ≥8, prostate-specific antigen concentration >20 ng/mL, or pathological node-positive). All patients underwent a staging pelvic lymph node dissection. Patients were randomly assigned (1:1) to either androgen deprivation therapy (ADT; goserelin 10·8 mg every 3 months for 3 years) plus four cycles of docetaxel on day 2 at a dose of 70 mg/m(2) and estramustine 10 mg/kg per day on days 1-5, every 3 weeks, or ADT only. The randomisation was done centrally by computer, stratified by risk factor. Local treatment was administered at 3 months. Neither patients nor investigators were masked to treatment allocation. The primary endpoint was relapse-free survival in the intention-to-treat population. Follow-up for other endpoints is ongoing. This study is registered with ClinicalTrials.gov, number NCT00055731. FINDINGS: We randomly assigned 207 patients to the ADT plus docetaxel and estramustine group and 206 to the ADT only group. Median follow-up was 8·8 years (IQR 8·1-9·7). 88 (43%) of 207 patients in the ADT plus docetaxel and estramustine group had an event (relapse or death) versus 111 (54%) of 206 in the ADT only group. 8-year relapse-free survival was 62% (95% CI 55-69) in the ADT plus docetaxel and estramustine group versus 50% (44-57) in the ADT only group (adjusted hazard ratio [HR] 0·71, 95% CI 0·54-0·94, p=0·017). Of patients who were treated with radiotherapy and had data available, 31 (21%) of 151 in the ADT plus docetaxel and estramustine group versus 26 (18%) of 143 in the ADT only group reported a grade 2 or higher long-term side-effect (p=0·61). We recorded no excess second cancers (26 [13%] of 207 vs 22 [11%] of 206; p=0·57), and there were no treatment-related deaths. INTERPRETATION: Docetaxel-based chemotherapy improves relapse-free survival in patients with high-risk localised prostate cancer. Longer follow-up is needed to assess whether this benefit translates into improved metastasis-free survival and overall survival. FUNDING: Ligue Contre le Cancer, Sanofi-Aventis, AstraZeneca, Institut National du Cancer.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/07/2015
• Auteurs : Martin OudinFederica OudinAnne-Christine Bécard
• Organismes : Centre de Recherche en Droit Privé (CRDP)

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• Type de publi. : Article dans une revue
• Date de publi. : 29/06/2015
• Auteurs : Maria ValkonenInge M. WoutersMartin TäubelHelena RintalaVirissa LentersRitva VasaraJon GenuneitCharlotte Braun-FahrländerRenaud PiarrouxErika von MutiusDick HeederikAnne Hyvärinen
• Organismes : Department of Health Protection Department of Environmental Science Division of Environmental Epidemiology Department of Health Protection Department of Health Protection Division of Environmental Epidemiology Department of Health Protection Institute of Epidemiology Université de Bâle = University of Basel = Basel Universität Infections Parasitaires : Transmission, Physiopathologie et Thérapeutiques Ludwig-Maximilians University [Munich] Division of Environmental Epidemiology Department of Health Protection
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Background :The increase in prevalence of asthma and atopic diseases in Western countries has been linked to aspects of microbial exposure patterns of people. It remains unclear which microbial aspects contribute to the protective farm effect. Objective :The objective of this study was to identify bacterial groups associated with prevalence of asthma and atopy, and to quantify indoor exposure to some of these bacterial groups. Methods :A DNA fingerprinting technique, denaturing gradient gel electrophoresis (DGGE), was applied to mattress dust samples of farm children and control children in the context of the GABRIEL Advanced study. Associations between signals in DGGE and atopy, asthma and other allergic health outcomes were analyzed. Quantitative DNA based assays (qPCR) for four bacterial groups were applied on the dust samples to seek quantitative confirmation of associations indicated in DNA fingerprinting. Results :Several statistically significant associations between individual bacterial signals and also bacterial diversity in DGGE and health outcomes in children were observed. The majority of these associations showed inverse relationships with atopy, less so with asthma. Also, in a subsequent confirmation study using a quantitative method (qPCR), higher mattress levels of specifically targeted bacterial groups - Mycobacterium spp., Bifidobacteriaceae spp. and two different clusters of Clostridium spp. - were associated with a lower prevalence of atopy. Conclusion :DNA fingerprinting proved useful in identifying bacterial signals that were associated with atopy in particular. These findings were quantitatively confirmed for selected bacterial groups with a second method. High correlations between the different bacterial exposures impede a clear attribution of protective effects to one specific bacterial group. More diverse bacterial flora in mattress dust may link to microbial exposure patterns that protect against development of atopic diseases.

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Fichiers liés : fetchObject.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/06/2015
• Auteurs : Marie FretinAnne FerlayMarie-Christine M.-C. MontelEtienne RifaBruno MartinCéline Delbès
• Organismes : Unité Mixte de Recherche Fromagère Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche Fromagère Unité Mixte de Recherche Fromagère Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche Fromagère

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/06/2015
• Auteurs : Christian HoffmannAnne Briançon-MarjolletPhilippe BrulardJean-Luc CracowskiJulien DouadyMyriam Houssay-HolzschuchPascal LafourcadeIsabelle Le BrunSigne SeidelinSophie Térouanne
• Organismes : Hélium : du fondamental aux applications Education, Cultures, Politiques Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Université Joseph Fourier - Grenoble 1 Université Joseph Fourier - Grenoble 1 Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] Pacte, Laboratoire de sciences sociales Université Grenoble Alpes [2016-2019] Université Joseph Fourier - Grenoble 1 Université Joseph Fourier - Grenoble 1 [GIN] Grenoble Institut des Neurosciences Nano-Optique et Forces Université Joseph Fourier - Grenoble 1

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Résumé : Nous décrivons et analysons dans cette communication le fonctionnement d’un groupe d’enseignants et d’enseignants-chercheurs qui contribue au développement professionnel de chacun de ses membres d’une part, et qui devient une source durable d’innovations pédagogiques dans notre établissement d’autre part.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/06/2015
• Auteurs : Sanja MikićBrigitte GouesnardVioleta AndelkovicStanisavljević DušanAnne ZanettoDelphine MadurCyril BaulandJacques LabordeMira MilisavljevićMilisav StojakovićAlain Charcosset
• Organismes : Institute of Field and Vegetable Crops [Novi Sad] Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Research Institute Institute of Field and Vegetable Crops [Novi Sad] Domaine expérimental de Melgueil Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Unité expérimentale du maïs University of Belgrade Institute of Field and Vegetable Crops [Novi Sad] Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale)

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Résumé : Traditional landraces adapted to local conditions harbour alleles for traits of interest and may be of valuable contribution in enhancing the stability of maize production under increasing challenges of climatic changes. It is therefore of great importance to preserve and assess local maize populations as a potential source of favourable agronomic traits. As a part of the bilateral project DIVERZEATY between Serbia and France (2014-2015), ten local landraces and ten inbred lines, derived from local landraces of the Maize Research Institute Zemun Polje gene bank and the Institute of Field and Vegetable Crops collection, were characterised at a pilot scale. The analysed accessions from diverse regions of former SFR Yugoslavia were genotyped with MaizeSNP50 BeadChip and allelic frequencies for landraces were estimated from the bulked DNA. Principal coordinate analyses showed the genotypes cover a range of diversity. Four local dent landraces grouped with Corn Belt populations, four populations grouped closely to European OPVs and Northern flints, one landrace with Italian flints and one was grouped in the Mexican cluster within the first two axes and with Corn Belt on the third and fourth coordinates. Two inbred lines, developed from the Montenegrin landraces, and one inbred line, derived from a Slovenian landrace, grouped with Northern flint lines, whereas the others clustered with Stiff Stalk ones. The landraces and lines fit well to historical data about their origin and introduction of maize in the region.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/06/2015
• Auteurs : Anne DupuyAmandine RochedyC. Sarrat
• Organismes : Centre d'Etude et de Recherche Travail Organisation Pouvoir Centre d'Etude et de Recherche Travail Organisation Pouvoir Danone Research

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Résumé : The diet of young eaters: a specific requirement requiring a reorganisation of family eating habits L’alimentation des jeunes mangeurs : un besoin spécifique entrainant une réorganisation alimentaire familiale We decided to take a look at what children eat by focusing on some analyses and results from a research programme on the diet of very young eaters, i.e. children aged between 0 and 3 (Dupuy and Rochedy, 2015). By analysing the underside of domestic and parental production in respect of the diet of small children, the report will focus on the supply journey, storage methods, culinary techniques, table manners and post-meal practices, describing them in terms of different life stages and also in respect of the development and socialisation of children. From a sociological point of view, how can we analyse the parental practices related to the act of feeding alongside those related to the construction of the list, or even the register, of what young children eat as a result of diversification? The various aspects of the work of parents have been investigated (Vandelac et al., 1985): the material work (shopping, preparing food and feeding the child/children but also the rest of the family, etc.), the cognitive work (thinking about what to eat and how to prepare it and anticipating the shopping that needs to be done, etc.) and the sentimental and relational work (family cohesion, being together, conversations/discussions around the child's diet, pleasure, conviviality and the child's well-being, etc.). It then becomes possible to question the evidence of this social fact: studying the work of parents in respect of the diet of young eaters in order to understand the changes, the disparities and the inequalities as well as the construction of the dietary practices of young eaters and the impact of parental work on their socialisation. This line of questioning, which is situated at the crossroads of the sociology of food, childhood, the family, health and gender relations, demands that particular attention be given to the juxtaposition and the combination of several dimensions. Firstly, the social construction of childhood (and early childhood) with the current place of the child and the small child, of children and small children, of childhood and early childhood, in the family, in culture and, more widely, the society under examination, which creates understanding of the socialisation, and particularly the multiple facets (horizontal, vertical and inverse) of food socialisation and the underlying inter/intra-generational relationships. Furthermore, the life stages and diet of the child are taken into account in the process of constructing the list of food (construction of likes and dislikes, rejections, preferences, neophobia, pleasure and emotion) alongside the prevalent childcare norms today. Finally, the issue of domestic and parental work (mental and physical tasks and the division and inequality of work within the family) and the "care" aspect, i.e. "thinking about others", which includes tangible and intangible practices, such as "emotional" components, provide an insight into the complexity of this task. Several points concerning the study are worthy of particular attention. The first relates to the fact that it takes into account a change in the child's diet from birth with milk given to begin with (dietary diversification with the first purée and then textured food with the introduction of lumps) until the child is integrated into family mealtimes, both physically and symbolically, by being served the same food as the rest of the family. These changes require ongoing readjustments in the feeding environment. Furthermore, this study takes a look at the practices and representations of the young child's diet from the point of view of the feeding environment while also considering what the child does with what he receives. Next, transitory ritualisation processes will be considered in order to reflect on the issue of these small rites that enable the child's socialisation and to verbalise the unspoken organisational aspects of the feeding environment in terms of certain cognitive shortcuts that are far from insignificant in daily life, comprising a vital process for parental organisation and, more broadly, for the feeding environment. The "transitory" dimension made it possible to put change and the dynamics of child and adult adaptation at the centre of the ritualisation of daily life as a result of the swings and transitions at work during food socialisation leading the child towards a non-specific diet. Thus, by analysing the diet of young children in this way, it was possible to study the various mental and physical pressures present in the feeding environment and the disparities at work in the threefold work of acquisition-transformation, relationship and love involved in the feeding role. Here again, the plurality and the complexity observed made it possible to re-question the division of domestic and parental tasks in respect of food during early childhood both in practice and in terms of values. Finally, implicitly throughout this study, we looked at the effects of the various educational influences on the processes of food socialisation in the child. The more a person is involved in the feeding role, the more that person has an influence on the relationship between food and the child's health, pleasure, well-being, self-fulfilment and development (Dupuy, 2013, 2014). Consequently, the socialisation processes experienced with the child are complicated, even more so given the concerns that weigh heavily on early childhood, which are currently centred on the importance of feeding children tasty healthy food in the first 1000 days of their lives. Nutritional needs, dietary needs and emotional needs are combined and are translated into, among other things, a sense of catching up in the feeding methods used or by parental guilt and also by a "stencil effect" (Fischler, 1990) in terms of both the list of foods offered to the child and the way in which the child is fed depending on the circumstances, the place, the time, the effect produced, etc. These elements can influence the socialisation processes at work in the child, i.e. what the child receives, how he experiences it and relates to it emotionally and, more importantly, what he takes away from it. Consequently, in the first part, we will set out the context and the challenges of children's diets in order to set the stage for questions involving the concerns surrounding the relationships between diet and health and diet and transmission for early childhood as a result of the importance placed on the first 1000 days in the life of a child. This will provide an opportunity to put these notions back in the centre of individual, collective and social dynamics. The second part will deal with the unequal distribution of the feeding work in respect of the young child. A third part will look at the empirical data of this study, and will be broken down into discussions on the methodology employed and on the study populations in the two geographical areas of France: Toulouse, Paris and their respective suburbs. Finally, the fourth and fifth parts will revisit two particular results from our research. We will discuss the organisational logic and the processes of food socialisation in order to gain an understanding of the evolution of the dietary act by moving away from the specific in favour of the general. We will then suggest a description and an analysis of the complex and unequal feeding work undertaken by parents. Bibliography: Dupuy A., 2013, Plaisirs alimentaires, Socialisation des enfants et des adolescents, Rennes, Presses Universitaires de Rennes. Dupuy A., 2014, « Regard(s) « sur » et « par » l’alimentation pour renverser et comprendre comment sont renversés les rapports de générations : l’exemple de la socialisation alimentaire inversée », Enfances Familles Générations, p. 79-108. Dupuy A et Rochedy A., 2015, L’alimentation des O-3 ans. Compréhension des processus de socialisations alimentaires des enfants entre 0 et 3 ans et étude des logiques de co-socialisation et de co-éducation de l’entourage nourricier, Rapport de Recherche CNRS – Blédina. Fischler C., 1990, L’homnivore, Paris, Odile Jacob. Vandelac L., Bélisle D., Gauthier A. et Pinard Y., 1985, Du travail et de l’amour, les dessous de la production domestique, Québec, Saint-Martin.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/06/2015
• Auteurs : Thomas BriocheRémi DemangelAllan PaganoDamien MartinMaria Fernanda de TorresRémi RoumanilleAnne BonnieuGuillaume PyAngèle Chopard
• Organismes : Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme Dynamique Musculaire et Métabolisme

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Résumé : Beta-hydroxy-beta-methylbutyrate supplementation prevents muscle atrophy and aerobic fitness decrease induced by hindlimb suspension in mice . 36. Annual Meeting of the International Society for Gravitational Physiology

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Fichiers liés : 2015_Brioche_ISGP_1.pdf

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