Anne Martin

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/05/2015
• Auteurs : Martin Anne
• Organismes : DRM MOST

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Résumé : Cette recherche porte sur l’introduction de la comptabilité analytique dans une université française, analysée au travers de la Théorie de l’acteur-réseau (ANT). Cet outil de gestion est une contrainte réglementaire opérationnalisant la tendance « New Public Management » (NPM) contenue dans la réforme publique actuelle. Pour ce faire, une recherche-expérimentation a été menée dans une université, et les résultats montrent qu’un actant issu du contexte et de l’histoire de l’organisation a eu une influence prépondérante sur la forme de l’outil.

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Fichiers liés : Outils de gestion et services publics - le cas de la comptabilité analytique à l'université.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/05/2015
• Auteurs : Martin Anne
• Organismes : DRM MOST

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Résumé : Cette recherche porte sur l’introduction de la comptabilité analytique dans une université française, analysée au travers de la Théorie de l’acteur-réseau (ANT). Cet outil de gestion est une contrainte réglementaire opérationnalisant la tendance « New Public Management » (NPM) contenue dans la réforme publique actuelle. Pour ce faire, une recherche-expérimentation a été menée dans une université, et les résultats montrent qu’un actant issu du contexte et de l’histoire de l’organisation a eu une influence prépondérante sur la forme de l’outil.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/05/2015
• Auteurs : Isabelle HeardIsabelle EtienneyValérie PotardIsabelle Poizot-MartinCatherine MooreAnne-Carole C LesageEmmanuelle RessiotCatherine Crenn-HebertJ F FlejouHeather CubieDominique CostagliolaTeresa M Darragh
• Organismes : Centre National de Référence pour les Papillomavirus Humains - Génétique, Papillomavirus et Cancer Humain CHU Pitié-Salpêtrière [AP-HP] Groupe Hospitalier Diaconesses Croix Saint-Simon Institut Pierre Louis d'Epidémiologie et de Santé Publique Rhumatologie [Sainte- Marguerite - APHM] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Scottish Human Papillomavirus Reference Laboratory [Edinburgh, United Kingdom] Groupe Hospitalier Diaconesses Croix Saint-Simon Rhumatologie [Sainte- Marguerite - APHM] Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Hôpital Louis Mourier - AP-HP [Colombes] Hôpitaux Universitaires de l'Est Parisien [Paris] CHU Saint-Antoine [AP-HP] Scottish Human Papillomavirus Reference Laboratory [Edinburgh, United Kingdom] Institut Pierre Louis d'Epidémiologie et de Santé Publique University of San Francisco
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : Background. Although human immunodeficiency virus (HIV)-infected women are at high risk for anal cancer, few data have been published on prevalence of and risk factors for anal precancer and potential screening strategies in this risk group. Methods. A cross-sectional anal screening study was nested in a gynecological cohort of HIV-infected women. Anal swab specimens were collected for cytology and human papillomavirus (HPV) testing. High-resolution anoscopy, with biopsy when indicated, was systematically performed. Results. Among the 171 enrolled women, median age was 47.3 years and 98% were receiving combination antiretroviral therapy. Median CD4 + count was 655 cells/µL and HIV load was <50 copies/mL in 89% of subjects. High-grade anal intraepithelial neoplasia or worse (HG-AIN+) was diagnosed in 12.9% (n = 21). In multivariable analysis, a history of cervical squamous intraepithelial lesion (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.1-16.4) and anal HPV-16 infection (OR, 16.1; 95% CI, 5.4-48.3) was associated with increased risk of HG-AIN+. Abnormal anal cytology and HPV-16 infection performed best as a screening strategy for HG-AIN+ histology, with positive likelihood ratios of 3.4 (95% CI, 2.3-5.1) and 4.7 (95% CI, 2.5-8.7) and negative likelihood ratios of 0.2 (95% CI, .07-.8) and 0.4 (95% CI, .2-.9), respectively. Conclusions. HIV-infected women with a history of HPV-associated cervical disease are at increased risk for HG-AIN+ and should be offered anal cancer screening. Anal cytology and HPV-16 genotyping had the best screening performance. Anal cytology is easy to perform routinely; it may be the best candidate for screening for HG-AIN among HIV-infected women.

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Fichiers liés : civ049.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/05/2015
• Auteurs : Anne GierschPatrick PonceletRémi L. CapaBrice MartinCéline DuvalMaxime CurziettiMarc HoonackerMitsouko van AsscheLaurence Lalanne
• Organismes : Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Service universitaire de réhabilitation, Centre référent lyonnais en réhabilitation et en remédiation cognitive (CL3R) Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie
• Publié dans Schizophrenia Research: Cognition le 27/10/2020

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Résumé : We review studies suggesting time disorders on both automatic and subjective levels in patients with schizophrenia. Patients have difficulty explicitly discriminating between simultaneous and asynchronous events, and ordering events in time. We discuss the relationship between these difficulties and impairments on a more elementary level. We showed that for undetectable stimulus onset asynchronies below 20 ms, neither patients nor controls merge events in time, as previously believed. On the contrary, subjects implicitly distinguish between events even when evaluating them to be simultaneous. Furthermore, controls privilege the last stimulus, whereas patients seem to stay stuck on the first stimulus when asynchronies are sub-threshold. Combining previous results shows this to be true for patients even for asynchronies as short as 8 ms. Moreover, this peculiarity predicts difficulties with detecting asynchronies longer than 50 ms, suggesting an impact on the conscious ability to time events. Difficulties on the subjective level are also correlated with clinical disorganization. The results are interpreted within the framework of predictive coding which can account for an implicit ability to update events. These results complement a range of other results, by suggesting a difficulty with binding information in time as well as space, and by showing that information processing lacks continuity and stability in patients. The time perspective may help bridge the gap between cognitive impairments and clinical symptoms, by showing how the innermost structure of thought and experience is disrupted.

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Fichiers liés : islandora_66357.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2015
• Auteurs : Anne Duvoid-GuillouNicola RomanòFrederik SteynKarine AbitbolPaul Le TissierXavier BonnefontChen ChenPatrice MollardAgnès O Martin
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle The University of Queensland Institut de Génomique Fonctionnelle University of Edinburgh Institut de Génomique Fonctionnelle The University of Queensland Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans Endocrinology le 22/10/2020

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Résumé : The pattern of prolactin (PRL) secretion depends on the physiological state. Due to insufficient detection sensitivity of existing assays, the precise description of these patterns in mice is lacking. We described an ultrasensitive ELISA assay that can detect mouse PRL in small fractions of whole blood, allowing longitudinal studies of PRL secretion profiles in freely moving mice. Over a 24-hour period, males displayed no oscillation in PRL levels, whereas virgin and lactating females showed large pulses. Peaks of PRL secretion reached 30-40 ng/mL in lactating female mice and rarely exceeded 10 ng/mL in virgin females. These pulses of PRL in lactating females were associated with suckling. The return of pups after an experimental 12-hour weaning induced a pulse of PRL release, reaching 100 ng/mL. This approach also enabled us to assess the inhibitory tone from hypothalamic dopamine neurons on PRL secretion. We used a dopamine D2 receptor antagonist to relieve pituitary lactotrophs from the tuberoinfundibular dopaminergic inhibitory tone and demonstrate a D2-induced PRL rise that can be used to evaluate both the secretory capacity of lactotrophs and the magnitude of the inhibitory tone on pituitary PRL release. We demonstrate that, although lactotroph function is altered to enhance chronic PRL output, their secretory response to acute stimulus is not modified during lactation and that chronic hyperprolactinemia is linked to a lower inhibitory tone. The combination of a sensitive PRL ELISA and administration of D2 receptor antagonist provide a unique opportunity to investigate the function and plasticity of the lactotroph axis in freely moving mice.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2015
• Auteurs : Emilie PastelJean-Christophe PointudGaëlle LoubeauChristian DaniKarem SlimGwenaëlle MartinFanny VolatIsabelle Sahut-BarnolaPierre ValAntoine MartinezAnne-Marie Lefrançois-Martinez
• Organismes : Génétique, Reproduction et Développement Génétique, Reproduction et Développement Génétique, Reproduction et Développement Institut de Biologie Valrose CHU Estaing [Clermont-Ferrand] CHU Estaing [Clermont-Ferrand] Institut des Maladies Métaboliques et Cardiovasculaires Interactions génétiques et cellulaires au cours de la différenciation Génétique, Reproduction et Développement Génétique, Reproduction et Développement Génétique, Reproduction et Développement
• Publié dans Endocrinology le 22/10/2020

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Résumé : Aldose reductases (AKR1B) are widely expressed oxidoreductases whose physiological function remains elusive. Some isoforms are genuine prostaglandin F2α (PGF2α) synthases, suggesting they might influence adipose homeostasis because PGF2α inhibits adipogenesis. This was shown by Akr1b7 gene ablation in the mouse, which resulted in increased adiposity related to a lower PGF2α content in fat. Yet humans have no ortholog gene for Akr1b7, so the role of aldose reductases in human adipose homeostasis remains to be explored. We analyzed expression of genes encoding human and mouse aldose reductase isoforms in adipose tissues and differentiating adipocytes to assess conserved mechanisms regulating PGF2α synthesis and adipogenesis. The Akr1b3 gene encoded the most abundant isoform in mouse adipose tissue, whereas Akr1b7 encoded the only isoform enriched in the stromal vascular fraction. Most mouse aldose reductase gene expression peaked in early adipogenesis of 3T3-L1 cells and diminished with differentiation. In contrast with its mouse ortholog Akr1b3, AKR1B1 expression increased throughout differentiation of human multipotent adipose-derived stem cells, paralleling PGF2α release, whereas PGF2α receptor (FP) levels collapsed in early differentiation. Pharmacological inhibition of aldose reductase using Statil altered PGF2α production and enhanced human multipotent adipose-derived stem adipocyte differentiation. As expected, the adipogenic effects of Statil were counteracted by an FP agonist (cloprostenol). Thus, in both species aldose reductase-dependent PGF2α production could be important in early differentiation to restrict adipogenesis. PGF2α antiadipogenic signaling could then be toned down through the FP receptor or aldose reductases down-regulation in human and mouse cells, respectively. Our data suggest that aldose reductase inhibitors could have obesogenic potential.

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Fichiers liés : endo1671.pdf

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• Type de publi. :
• Date de publi. : 26/04/2015
• Auteurs : K. GrybelEugénie CanonMareike PendzialekMaria SchindlerJacqueline GurkeThierry BlachèreMurielle GodetBernd FischerAnne Navarrete SantosVéronique Duranthon
• Organismes : Department of Anatomy and Cell Biology Biologie du Développement et Reproduction Department of Anatomy and Cell Biology Department of Anatomy and Cell Biology Department of Anatomy and Cell Biology Institut cellule souche et cerveau Université de Lyon (COMUE) Institut cellule souche et cerveau Department of Anatomy and Cell Biology Department of Anatomy and Cell Biology Biologie du Développement et Reproduction

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Résumé : DNA methylation is a conservative epigenetic marker. A correct DNA methylation pattern is essential for embryonic development. Mammalian embryos gain a complete de novo DNA methylation design around implantation. DNA methylation is a potential mechanism of periconceptional programming, suggesting that the DNA methylation pattern of developing embryo might be affected in distinct ways, depending on nutritional and hormonal signals. To expand this idea we have investigated the DNA methylation pattern of the promoter region of the POU5F1 (Oct4) pluripotency gene in preimplantation rabbit embryos at day 6 p.c (early gastrulation stage). The blastocysts were collected from healthy and diabetic rabbits. The POU5F1 promoter contains four conservative regions, which are embracing important elements for its transcription: proximal and distal enhancers (PE-1A, PE-1B, DE-1A), a SOX2/Oct4 binding site and hormone responding element (HRE). We have characterized the CpG islands methylation at all mentioned regions in two embryonic tissues: embryoblast and trophoblast, using bisulfite treatment, cloning and sequencing. The analysis has been successfully performed for the trophoblast tissue yet. A higher methylation of the CpG islands for HRE and at the beginning of first exon has been noticed in the trophoblast of diabetic embryos. A hypomethylation in trophoblast from diabetic embryos comparing to trophoblasts from healthy pregnancies was visible for proximal enhancer 1A (PE-1A) in frame of conservative region 3 (CR3). In this context, DNA methylation can be considered as a form of embryo developmental plasticity, which can promote metabolic disorders in adult life.

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• Type de publi. :
• Date de publi. : 21/04/2015
• Auteurs : J. MorettoA. GuglielmettiH. MartinM. NappeyAnne Prigent-TessierCéline Demougeot
• Organismes : Fonctions et dysfonctions épithéliales - UFC (EA 4267) Fonctions et dysfonctions épithéliales - UFC (EA 4267) Fonctions et dysfonctions épithéliales - UFC (EA 4267) Fonctions et dysfonctions épithéliales - UFC (EA 4267) Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] Fonctions et dysfonctions épithéliales - UFC (EA 4267)

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• Type de publi. : Article dans une revue
• Date de publi. : 17/04/2015
• Auteurs : Stéphane GaudryDavid HajageFrédérique SchortgenLaurent Martin-LefevreFlorence TubachBertrand PonsEric BouletAlexandre BoyerNicolas LerolleGuillaume ChevrelDorothee CarpentierAlexandre LautretteAnne BretagnolJulien MayauxMarina ThirionPhilippe MarkowiczGuillemette ThomasJean DellamonicaJack RichecoeurMichaël DarmonNicolas de ProstHodane YonisBruno MégarbaneYann LoubieresClarisse BlayauJulien MaizelBenjamin ZuberSaad NseirNaike BigeIsabelle HoffmannJean-Damien RicardDidier Dreyfuss
• Organismes : Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables Hôpital Louis Mourier - AP-HP [Colombes] Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon AP-HP - Hôpital Bichat - Claude Bernard [Paris] CHU Pointe-à-Pitre/Abymes [Guadeloupe] Centre Hospitalier René Dubos [Pontoise] Hôpital Pellegrin Centre Hospitalier Universitaire d'Angers CHU Rouen CHU Gabriel Montpied [Clermont-Ferrand] Centre Hospitalier Régional d'Orléans CHU Pitié-Salpêtrière [AP-HP] Hôpital Nord [CHU - APHM] Centre Hospitalier Universitaire de Nice Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital Henri Mondor Hôpital de la Croix-Rousse [CHU - HCL] Université Paris Diderot, Sorbonne Paris Cité, Paris, France CHI Poissy-Saint-Germain CHU Tenon [AP-HP] CHU Amiens-Picardie Centre Hospitalier de Versailles André Mignot Lille Inflammation Research International Center - U 995 CHU Saint-Antoine [AP-HP] CIC - CHU Bichat Hôpital Louis Mourier - AP-HP [Colombes] Hôpital Louis Mourier - AP-HP [Colombes]
• Publié dans Trials le 31/10/2020

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Résumé : BACKGROUND: There is currently no validated strategy for the timing of renal replacement therapy (RRT) for acute kidney injury (AKI) in the intensive care unit (ICU) when short-term life-threatening metabolic abnormalities are absent. No adequately powered prospective randomized study has addressed this issue to date. As a result, significant practice heterogeneity exists and may expose patients to either unnecessary hazardous procedures or undue delay in RRT. METHODS: This is a multicenter, prospective, randomized, open-label parallel-group clinical trial that compares the effect of two RRT initiation strategies on overall survival of critically ill patients receiving intravenous catecholamines or invasive mechanical ventilation and presenting with AKI classification stage 3 (KDIGO 2012). In the 'early' strategy, RRT is initiated immediately. In the 'delayed' strategy, clinical and metabolic conditions are closely monitored and RRT is initiated only when one or more events (severity criteria) occur, including: oliguria or anuria for more than 72 hours after randomization, serum urea concentration >40 mmol/l, serum potassium concentration >6 mmol/l, serum potassium concentration >5.5 mmol/l persisting despite medical treatment, arterial blood pH <7.15 in a context of pure metabolic acidosis (PaCO2 < 35 mmHg) or in a context of mixed acidosis with a PaCO2 ≥ 50 mmHg without possibility of increasing alveolar ventilation, acute pulmonary edema due to fluid overload despite diuretic therapy leading to severe hypoxemia requiring oxygen flow rate >5 l/min to maintain SpO2 > 95% or FiO2 > 50% under invasive or noninvasive mechanical ventilation. The primary outcome measure is overall survival, measured from randomization (D0) until death, regardless of the cause. The minimum follow-up duration for each patient will be 60 days. Two interim analyses are planned, blinded to group allocation. It is expected that there will be 620 subjects in all. CONCLUSIONS: The AKIKI study will be one of the very few large randomized controlled trials evaluating mortality according to the timing of RRT in critically ill patients with AKI classification stage 3 (KDIGO 2012). Results should help clinicians decide when to initiate RRT. BACKGROUND: ClinicalTrials.gov NCT01932190.

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Fichiers liés : s13063-015-0718-x.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2015
• Auteurs : Gonzalo de La MorenaBogdan A. PopescuMartin PenickaTolga OzyigitJose David Rodrigo CarboneroAlessandro SalustriNico van de VeireRalph Stephan von BardelebenDragos VinereanuJens-Uwe VoigtJose Luis ZamoranoAnne BernardErwan DonalRoberto M. LangLuigi P. BadanoPatrizio LancellottiLuis CaballeroSeisyou KouRaluca DulgheruNatalia GonjilashviliGeorge D. AthanassopoulosDaniele BaroneMonica BaroniNuno CardimJose Juan Gomez De DiegoMaria Jose OlivaAndreas HagendorffKrasimira HristovaTeresa LopezJulien MagneChristophe Martinez
• Organismes : Cardiology Service de cardiologie Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Laboratoire Traitement du Signal et de l'Image Groupe Interdisciplinaire de Génoprotéomique Appliquée Hospital Clínico Universitario Virgen de la Arrixaca = University Hospital Virgen de la Arrixaca [Murcia] Groupe Interdisciplinaire de Génoprotéomique Appliquée
• Publié dans European Heart Journal - Cardiovascular Imaging le 25/10/2020

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Résumé : AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols. The majority of the Doppler diastolic parameters (e', E/e') as well as right ventricle systolic s' wave velocity were similar in men and women. Left ventricle s' wave velocity was higher in men than in women. E wave and e' were higher in younger subjects and decreased progressively in the older ones. E/e' ratio increased with ageing. Septal e' \textless8 cm/s was present in 19.7% of the subjects in the 40-60 year group and in 55% of those in the ≥60 year group. However, the cut-off value of average E/e' or lateral E/e' remained \textless15 or 13, respectively, in the majority of patients. CONCLUSION: The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology. These data highlight the need of using age-specific reference values especially for the diagnosis of LV systolic and diastolic dysfunction and for the estimation of LV filling pressures

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