Catherine Gall

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Perrine PortierMarion Fischer-Le SauxChristophe MougelCatherine LerondelleDavid ChapulliotJean ThioulouseXavier Nesme
• Organismes : Laboratoire d'Ecologie Microbienne - UMR 5557 Pathologie Végétale Laboratoire d'Ecologie Microbienne - UMR 5557 Laboratoire d'Ecologie Microbienne - UMR 5557 Laboratoire d'Ecologie Microbienne - UMR 5557 Ecologie quantitative et évolutive des communautés [LBBE] Laboratoire d'Ecologie Microbienne - UMR 5557
• Publié dans Applied and Environmental Microbiology le 01/11/2020

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Résumé : Biovar 1 of the genus Agrobacterium consists of at least nine genomic species that have not yet received accepted species names. However, rapid identification of these organisms in various biotopes is needed to elucidate crown gall epidemiology, as well as Agrobacterium ecology. For this purpose, the AFLP methodology provides rapid and unambiguous determination of the genomic species status of agrobacteria, as confirmed by additional DNA-DNA hybridizations. The AFLP method has been proven to be reliable and to eliminate the need for DNA-DNA hybridization. In addition, AFLP fragments common to all members of the three major genomic species of agrobacteria, genomic species G1 (reference strain, strain TT111), G4 (reference strain, strain B6, the type strain of Agrobacterium tumefaciens), and G8 (reference strain, strain C58), have been identified, and these fragments facilitate analysis and show the applicability of the method. The maximal infraspecies current genome mispairing (CGM) value found for the biovar 1 taxon is 10.8%, while the smallest CGM value found for pairs of genomic species is 15.2%. This emphasizes the gap in the distribution of genome divergence values upon which the genomic species definition is based. The three main genomic species of agrobacteria in biovar 1 displayed high infraspecies current genome mispairing values (9 to 9.7%). The common fragments of a genomic species are thus likely “species-specific” markers tagging the core genomes of the species.

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Fichiers liés : Portier2006-030.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Nabil BoughnimBernard YannouGwenola Yannou-Le BrisCatherine GallAndré Malsch
• Organismes : Laboratoire Génie Industriel - EA 2606 Centre Économie de la Production ALimentaire - UP1404 Laboratoire Génie Industriel - EA 2606 Centre Économie de la Production ALimentaire - UP1404 Laboratoire Génie Industriel - EA 2606 Centre Économie de la Production ALimentaire - UP1404 Laboratoire Génie Industriel - EA 2606 Centre Économie de la Production ALimentaire - UP1404 Laboratoire Génie Industriel - EA 2606 Centre Économie de la Production ALimentaire - UP1404

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Résumé : A world leader company in office furniture like Steelcase is moving its business from manufacturing physical products toward more integrated solutions for work environment. Through this new strategy, this company aims to develop a new business which makes possible to satisfy the various needs of customer and workspace users, to anticipate the future tendencies, organisational and cultural changes in work and to be in compliance with sustainability recommendations. The objective of this paper is to feature Steelcase company within its actual competing situation, to characterize from a design point of view, its know-how, its processes and tools. After this statement, we stress the issues raised by the shift from a current state of green product offer to sustainable integrated solutions of workplace. One of the main challenges is to monitor the emerging performances of the design alternatives - technical, economical, environmental and social - during the design process and to be able to comment a few variant solutions in a multicriteria way to the clients. The suggested solution is to adopt a modelling and capitalization approach for the performance measurement of workplace solutions.

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Fichiers liés : LCE2006_paper_141_Boughnim_al.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/12/2004
• Auteurs : Carole CarantaCatherine DogimontSandrine RuffelValerie NicaiseOlivier Le GallVéronique Decroocq
• Organismes : Génétique et Amélioration des Fruits et Légumes Génétique et Amélioration des Fruits et Légumes Génétique et Amélioration des Fruits et Légumes Unité Mixte de Recherche en Santé Végétale (INRA/ENITA) Unité Mixte de Recherche en Santé Végétale (INRA/ENITA) Unité Mixte de Recherche en Santé Végétale (INRA/ENITA)

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• Type de publi. : Article dans une revue
• Date de publi. : 15/10/2004
• Auteurs : Sylvain M Le GallPierre MenetonPhilippe MauduitCatherine Dreux
• Organismes : Développement et évolution
• Publié dans Regulatory Peptides le 28/10/2020

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Résumé : Epidermal growth factor (EGF) is present in kidney membranes as an integral type I precursor protein, enzymatically processed to release immunoreactive materials in urine or incubation medium. The aim of this work was the elucidation of both the anchor of the serine protease activity that processes pro-EGF, and the determination of the steps of the enzymatic processing. Quantification of EGF containing molecules by RIA following gel filtration analysis demonstrated that the membrane precursor is first shed from the kidney membrane principally into a 170-kDa soluble precursor. This entire ectodomain is further processed into a 70-kDa precursor and finally into the mature 5.9 kDa urinary EGF. These species correspond to the ones found in urines. Both shedding and maturation events are clearly realized by membrane anchored serine protease activity, which remains active in detergent. By use of wild-type and knockout mice urines, we found that tissue kallikrein (TK) was not involved in the regulation of this processing.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/11/2003
• Auteurs : Sylvain M Le GallRodolphe AugerCatherine DreuxPhilippe Mauduit
• Organismes : Institut de biochimie et biophysique moléculaire et cellulaire Développement et évolution
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : Epidermal growth factor receptor (EGFR) ligands are synthesized as type I membrane protein precursors exposed at the cell surface. Shedding of the ectodomain of these proteins is the way cells regulate the equilibrium between cell-associated and diffusible forms of these growth factors. Whereas the regulated shedding of transforming growth factor-alpha, HB-EGF, and amphiregulin precursors have been clearly established, regulation of full-length pro-EGF shedding has not been clearly demonstrated. Here, using both wild-type and M2 mutant CHO-K1 as well as HeLa cell lines transiently transfected with epitope-tagged rat pro-EGF expression plasmid, we demonstrate that these cells synthesize EGF as a high molecular weight membrane-associated precursor glycoprotein expressed at the cell surface. All cell lines are able to release the entire ectodomain of pro-EGF in the extracellular medium following juxtamembrane cleavage of the precursor once it is present at the cell surface. More significantly we clearly established that CHO-M2 and HeLa cells only constitutively release low levels of pro-EGF. This shedding is a regulated phenomenon in wild-type CHO cells where it can be induced by different agents such as phorbol 12-myristate 13-acetate (PMA), pervanadate, and serum but not by calcium ionophores. Using specific inhibitors as well as protein kinase C (PKC) depletion, PMA stimulation was shown to be completely dependent on PKC activation whereas pervanadate and serum stimulation were not. Regulated ectodomain shedding involves the activity of a zinc metalloprotease as determined by inhibition with phenantrolin and TAPI-2 and by the results obtained with the CHO-M2 shedding defective mutant cell line. Comparison of the ability of CHO and HeLa cell lines to shed pro-EGF and pro-TNF-alpha upon stimulation greatly suggests that TACE (ADAM 17) may not be the ectoprotease involved in the secretion of pro-EGF ectodomain and that this protease, which remains to be identified, shows a restricted cellular expression pattern.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Franck LedouxJean-Marc MotaAgnès ArnouldCatherine DuboisPascale Le GallYves Bertrand
• Organismes : Laboratoire de Méthodes Informatiques Laboratoire de Méthodes Informatiques SIGNAL-IMAGE-COMMUNICATION Centre d'études et de recherche en informatique et communications Laboratoire de Méthodes Informatiques SIGNAL-IMAGE-COMMUNICATION
• Publié dans Revue des Sciences et Technologies de l'Information - Série TSI : Technique et Science Informatiques le 31/10/2020

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Résumé : La représentation mathématique des objets géométriques, la complexité et le nombre d'algorithmes nécessaires à leur manipulation, sont des indices forts pour une utilisation aisée et bénéfique des méthodes formelles. Nous présentons dans cet article une étude de la spécifi- cation formelle d'une opération complexe et importante en modélisation géométrique. Il s'agit de l'opération de chanfreinage consistant à aplanir les angles vifs des objets 3D. Cette étude est menée dans le cadre de deux méthodes formelles, B (orientée modèles) et CA S L (orientée propriétés) avec pour objectif de privilégier la lisibilité par les experts du domaine. De plus, la formalisation et la rétro-ingéd'une méthodologie dédiée.

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Fichiers liés : TSI2001_2.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2001
• Auteurs : F. LedouxJean-Marc MotaA. ArnouldCatherine DuboisPascale Le GallYves Bertrand
• Organismes : Centre d'études et de recherche en informatique et communications Centre d'études et de recherche en informatique et communications

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2000
• Auteurs : Isabelle CatalaCatherine JusteN. BoehlerJacqueline FerezouM. AndréMichel RiottotC. LuttonH. LafontFrancis BornetT. Corring
• Organismes : Unité de recherche d'Écologie et Physiologie du Système Digestif Unité de recherche d'Écologie et Physiologie du Système Digestif Unité de recherche d'Écologie et Physiologie du Système Digestif
• Publié dans British Journal of Nutrition le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1996
• Auteurs : Christian NeriVéronique AlbanèseAnne Sophie LebreSébastien HolbertClaudine SaadaLydie BougueleretSebastian Meier-EwertIsabelle Le GallPhilippe MillasseauHung BuiCatherine GiudicelliCatherine MassartSophie GuillouPatricia GervyEric PoullierPhilippe RigaultJean WeissenbachGreg LennonIlya ChumakovJean DaussetHans LehrachDaniel CohenHoward M. Cann
• Organismes : Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Max Planck Institute for Molecular Genetics Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Centre National de la Recherche Scientifique Lawrence Livermore National Laboratory Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Max Planck Institute for Molecular Genetics Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain
• Publié dans Human Molecular Genetics le 26/10/2020

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Résumé : Expansion of polymorphic CAG and CTG repeats in transcripts is the cause of six inherited origin. neurodegenerative or neuromuscular diseases and may be involved in several other genetic disorders of the central nervous system. To identify new candidate genes, we have undertaken a large-scale screening project for CAG and CTG repeats in human reference cDNAs. We screened 100 128 brain cDNAs by hybridization. We also scanned GenBank expressed sequence tags for the presence of long CAG/CTG repeats in the extremities of cDNAs from several human tissues, Of the selected clones, 286 were found to represent new genes, and 72 have thus far been shown to contain CAG/CTG repeats, Our data indicate that CAG/CTG repeated 10 or more times are more likely to be polymorphic, and that new 3'-directed cDNAs with such repeats are very rare (1/2862). Nine new cDNAs containing polymorphic (observed heterozygote frequency: 0.05-0.90) CAG/CTG repeats have been currently identified in cDNAs, Ail of the cDNAs have been assigned to chromosomes, and six of them could be mapped with YACs to 1q32-q41, 3p14, 4q28, 3p21 and 12q13.3, 13q13.1-q13.2, and 19q13.43, Three of these clones are highly polymorphic and represent the most likely candidate genes for inherited neurodegenerative diseases and, perhaps, neuropsychiatric disorders of multifactorial origin.

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