COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study
- Type de publi. : Article dans une revue
- Date de publi. : 01/06/2021
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Auteurs :
Jérôme AvouacElodie DrumezEric HachullaRaphaèle SerorStéphanie Ducharme-BénardSoumaya El MahouEdouard PertuisetThao PhamHubert MarotteAmélie ServettazFanny DomontPascal ChazerainMathilde DevauxPascal ClaudepierreVincent LangloisArsène MekinianAlexandre Thibault Jacques MariaBéatrice BannevilleBruno FautrelJacques PouchotThierry ThomasRené-Marc FlipoChristophe RichezFlorence AeschlimannChristian AgardNassim Ait-AbdallahJean-David AlbertDidier AlcaisJean-Sébastien AllainYannick AllanoreBlanca Amador-BorreiroZahir AmouraEmma AndreAnaïs ArbaultJean-Benoît ArletLaurent ArnaudDenis ArniaudHerliette Arty-HueLucie AtlanAlexandra Audemard-VergerChristine Audoin-PajotVictor AudrenMaxime Bach-BunnerHélène Bacquet-DeschryverBrigitte Bader-MeunierNathalie BalandraudJean-Charles BalblancStéphane BallyFrédéric BanalPierre BarberyThomas BarnetcheAudre BarreletAndré BaschVincent BaumierGuillaume BayerSophie BayleCatherine BeauvaisRudie BeinatVéronique BelinRakiba BelkhirRuben BenainousAlexandre BelotMohammed BenammarMathilde BenhamouYgal BenhamouAhmed BenmansourPascal BennetBrigitte Bernoux-ManatElise BerthetEmilie BerthouxEwa BertoliniAdrien BigotAurélia Bisson-VaivreGilles BlaisonGilles BollaOlivier BonidanChristine BonnetRaphaël BorieMarie BossertLaurence BoudouFrançoise BouhourKévin BouillerBastien BouldoiresKarima BoussoualimEric BouvardRegine BrondinoPierre BuchlinLaurence CabantousPatrice CacoubSimon CadiouMaurizio CarteniAurélia CarbasseBrice CastelPascal CathebrasHervé CaumontAnnalisa CelantBenjamin ChaigneBenoît ChaillousRomuald ChampyAgnès CharcotPierre CharlesIsabelle Charlot-LambrechtCaroline CharpinEmmanuel ChatelusBernard ChaudierPascale ChertokXavier ChevalierMaxime ChevreauEmilie ChotardDelphine Chu Miow LinGaëlle ClavelCyril Clavel-OsorioFleur CohenGregory CohenMarie-Eve Colette-CedozNived CollercandyAntoine ColombeyChloé ComarmondBernard CombeCéline ComparonElodie ConstantPascal CoquerelleJustine CorliClémence CorreNathalie Costedoat-ChalumeauMarie CouretNatacha CourvoisierFabienne Coury-LucasCécile CoutarelFabrice CoutierRichard DamadeLaurence Daver-MalaterreSarahe DehimatMichel DelahousseEmilie Barrois-DelattreDelphine DenarieCamille DeprouwEmanuelle DernisAlban DerouxRenaud DesbarbieuxElise DescampsChantal DeslandreMarie DesmursJacques DespauxMarie DesplatsFrédérick DetreeValérie Devauchelle-PensecRobin DhotePhilippe DieudeYannick DieudonneElisabeth DiotGuillaume DirezDjamal-Dine DjeddiSarah DouvierBéatrice DrouetCatherine DucAngélique DucornetCarine Dufauret-LombardAlain DuhamelCécile DumaineAnne-Elisabeth DumelChantal Dumoulin-RichezAgnès DuquesneGéraldine DurandMariane Durandin-TruffinetPierre-Marie DuretMaïka DuvalMikaël EbboEsther EbsteinAndra Economu-DuboscStéphanie EmilieRomain EuvrardPhilippe EvonSylvie FabreDorothée FagedetMeryem FarhatMarion FauconierJacques FechtenbaumRenaud FeltenFanny FernandesNicole Ferreira-MaldentElodie FeurerAmandine FichetFrançoise FlaislerNans FlorensViolaine FoltzElisabeth FontangesJennifer ForetAnne-Claire FougerousseAnne Fouque-AubertCatherine Foutrier-MorelloHélène Francois-PradierLéa FrantzenPierre FritzAntoine FroissartJean FulpinPiera FuzibetFrancis GachesLaurence Gagneux-LemoussuMélanie Penhoat-GahierJoris GallandFrédérique GandjbakhchNicole GarnierThomas GarraudJean-François GarrotRomain GastaldiVéronique Gaud-ListratMaud Gauthier-PrieurDana GeorgescuNathalie GerardElisabeth Solau-GervaisChristelle GibertEric GibertGhislaine GillJérôme GillardMélanie GilsonPauline GimonnetJeanine-Sophie Giraudet-Le QuintrecAude Giraud-MoreletBaptiste GlaceCamille GlanowskiBertrand GodeauBruno GombertCamille Gonnet-GraciaTiphaine GoulenokPhilippe GoupilleOlivier GourmelenSophie Govindaraju-AudouardFranck GradosMartine Grall-LeroseyBruno GrardelAnne GraslandGilles GrateauMonica GrozaConstance GuillaudSéverine GuillaumeCaroline GuillibertXavier GuillotPhilippe GuilpainAline GuryMarie-Hélène GuyotCécile Hacquard-BouderMarie-Noelle HavardJean-Pierre HellierPascal HennequinBasile HenriotJulien HenryVéronique HentgenMarion HermetMuriel HerasseJulie HernandezMiguel HiePascal HilliquinOlivier HinschbergerAmbre Hittinger-RouxJan HolubarChristophe HudrySerge HuguenelClara JaccardJean-Michel, JacquemierBénédicte JamardCatherine JanSylvie JeanMathieu JouvrayPierre-Antoine JugeLaurent JuillardDenis JullienAnna KabalaAbdelkrim KabchouLudovic KarkowskiFrançoise KarmanFarid KemicheJérémy KeraenPierre KiefferIsabelle Kone-PautAbdeldajallil KoreichiMarie KostineSylvain La Batide AlanorePierre LafforgueSophie LahalleMarc LambertIsabelle LambrechtSylvain LanotAurélia LanteriJean-Paul LarbreAugustin LatourteChristian LavigneSophie Le Guen GueganGuillaume, Le GuennoDiane LeguyAgnès LebrunEmmanuel LedoultNathalie LegoupilErick LegrandCharlotte LejeuneOlivier LeloireChristophe LerouxRémi LeroyMarie Leroy-GouixTifenn LeturcqAmélie LeursCéline Leveque-MichaudFrançois-Xavier LimbachFrédéric LioteAnne LohsePierre Lozac'HVirginie LucasAurélie MadelonNadine Magy-BertrandMatthieu MahevasHélène MaillardThibault MailletSandrine Malochet-GuinamandQuentin MangonSylvie Marchou-LopezNathalie MargaritThierry MarhadourXavier MarietteClaire MartinAlexis MathianFrançois MaurierFrédéric MauryBetty Mazet-GuillaumeArnaud MazouyezHassan MazyadNadia Mehsen-CetreUlrich MeinzerIsabelle MelkiLaurent MesserCorinne MiceliMartin MichaudCatherine MichelMatthias MichelMathilde MichonAnne-Marie Milesi-LecatAnna MoltóMarie MolyOlivier MoranneGautier MorelHugo MorelJacques MorelFranck MorinLaurence MoulinierGuillaume MoulisBertrand MouraMinh NguyenSabine Nicolas-VulliermeHubert NiellyGaétane NocturneAurore NottezHenri-Olivier OllagnonIsabelle Pacaud-VitouxAnne PagnierCaroline ParisAntoine ParrotTristan PascartYasmina Pascaud-MansourLætitia PaulinStephan PavyLaurent PerardYves-Marie PersMicheline PhaMaud PichonAudrey PierreisnardGabrielle PizanaSylvaine PoignantElsa PoixAgnès PortierAntoine PouletSamira PlassardGrégory PugnetDéborah Puyraimond-ZemmourPierre Quartier-Dit-MaireMarion QuenetViviane QueyrelLoïc RaffrayPhilippe RemyMyriam RenardJessica ReneSabine RevuzBénédicte ReyGaëlle Richard-ColmantEtienne RiviereSébastien RiviereSophie RobinJulien RohmerIsabelle RoitgMélanie RomierMichel RollandMélanie RorizCarole RosenbergLinda RossiOlivier RothSid-Ahmed RouidiMathilde RoumierMickaël RousiereClémentine RousselinBénédicte RouviereChristian RouxFabienne RouxMarielle RouxNicolas RouxDiane RouzaudSylvie RozenbergIsabelle SaccoFatiha SadjiLaurent SaillerCarine SalliotJean-Hugues SalmonAlain SarauxJean SchmidtJulie SeguierJérémie SellamEric SenbelThomas SenePatricia SenetPascal SeveAurélie SicaudPerrine SmetsVincent SobanskiChristelle SordetElisabeth Sornay-RenduOdile Souchaud-DebouverieLætitia SparsaLionel SpielmannSarah SteibChloé StavrisCatherine StrausVictor StrotzPaulina SzaforsSéverine Taffignon-ClaveJustine SimoensClaire TheillacNora TenenbaumBenoît ThomachotNathalie TieulieSoizic TiriauAlice TisonEric ToussirotLudovic TrefondSophie TrijauSébastien TrouillierAnne-Priscille TrouvinMarie-Elise TruchetetMarc UlrichJacques VaquierEric VeillardLaurent VeillonGuillaume VialJean-François ViallardJudith VictorClaire VidonMathias VidonCamille VigneAlexandre VironeUrsula WarzochaDaniel WendlingClaude WerleCécile WibauxAlexandra WillemsMichel WisniewskiJuliette WoessnerBernadette Xerri-Campano
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Organismes :
Service de rhumatologie [CHU Cochin]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Service de médecine interne [Lille]
Institute for Translational Research in Inflammation - U 1286
Immunologie des Maladies Virales et Autoimmunes
CHU Tenon [AP-HP]
Centre Hospitalier Tourcoing
Centre Hospitalier René Dubos [Pontoise]
Assistance Publique - Hôpitaux de Marseille
Santé Ingénierie Biologie Saint-Etienne
Biologie Intégrative du Tissu Osseux
Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
Hôpital universitaire Robert Debré [Reims]
CHU Pitié-Salpêtrière [AP-HP]
Groupe Hospitalier Diaconesses Croix Saint-Simon
Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy]
Epidemiology in Dermatology and Evaluation in Therapeutics
CHU Saint-Antoine [AP-HP]
Centre Hospitalier Régional Universitaire [Montpellier]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
CHU Pitié-Salpêtrière [AP-HP]
CHU Pitié-Salpêtrière [AP-HP]
Hôpital Européen Georges Pompidou [APHP]
Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
Biologie Intégrative du Tissu Osseux
Centre Hospitalier Régional Universitaire [Lille]
CHU Bordeaux [Bordeaux]
Composantes innées de la réponse immunitaire et différenciation
Laboratoire Chrono-environnement (UMR 6249)
Centre Hospitalier Régional Universitaire de Besançon
CHU Tenon [AP-HP]
Maladies génétiques d'expression pédiatrique
Centre Hospitalier Régional Universitaire [Montpellier]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Centre Hospitalier Régional Universitaire [Montpellier]
Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
Centre Hospitalier Régional Universitaire [Montpellier]
- Publié dans The Lancet Rheumatology le 13/12/2019
Résumé : Background: Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is associated with severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases.Methods: In this cohort study, we analysed data from the French RMD COVID-19 cohort, which included patients aged 18 years or older with inflammatory rheumatic and musculoskeletal diseases and highly suspected or confirmed COVID-19. The primary endpoint was the severity of COVID-19 in patients treated with rituximab (rituximab group) compared with patients who did not receive rituximab (no rituximab group). Severe disease was defined as that requiring admission to an intensive care unit or leading to death. Secondary objectives were to analyse deaths and duration of hospital stay. The inverse probability of treatment weighting propensity score method was used to adjust for potential confounding factors (age, sex, arterial hypertension, diabetes, smoking status, body-mass index, interstitial lung disease, cardiovascular diseases, cancer, corticosteroid use, chronic renal failure, and the underlying disease [rheumatoid arthritis vs others]). Odds ratios and hazard ratios and their 95% CIs were calculated as effect size, by dividing the two population mean differences by their SD. This study is registered with ClinicalTrials.gov, NCT04353609.Findings: Between April 15, 2020, and Nov 20, 2020, data were collected for 1090 patients (mean age 55·2 years [SD 16·4]); 734 (67%) were female and 356 (33%) were male. Of the 1090 patients, 137 (13%) developed severe COVID-19 and 89 (8%) died. After adjusting for potential confounding factors, severe disease was observed more frequently (effect size 3·26, 95% CI 1·66-6·40, p=0·0006) and the duration of hospital stay was markedly longer (0·62, 0·46-0·85, p=0·0024) in the 63 patients in the rituximab group than in the 1027 patients in the no rituximab group. 13 (21%) of 63 patients in the rituximab group died compared with 76 (7%) of 1027 patients in the no rituximab group, but the adjusted risk of death was not significantly increased in the rituximab group (effect size 1·32, 95% CI 0·55-3·19, p=0·53).Interpretation: Rituximab therapy is associated with more severe COVID-19. Rituximab will have to be prescribed with particular caution in patients with inflammatory rheumatic and musculoskeletal diseases.
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