Justine Paulus

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El BaghdadiSara Espinosa-PadillaJosé Luis FrancoAntoine FroidureDavid HaginSarah HenricksonElena HsiehEystein HusebyeKohsuke ImaiYuval ItanErich JarvisTimokratis KaramitrosKai KisandCheng-Lung KuYun LingCarrie LucasLászló MaródiIsabelle MeytsJoshua MilnerKristina MironskaTomohiro MorioLisa NgLuigi NotarangeloCliona O’FarrellySatoshi OkadaAnna PlanasLluis Quintana-MurciLaurent ReniaIgor ResnickCarlos Rodríguez-GallegoVanessa Sancho-ShimizuAnna SedivaMikko SeppänenAnna ShcherbinaOndrej SlabyAndrew SnowPere Soler-PalacínAndrás SpaanIvan TancevskiStuart TangyeSathishkumar RamaswamyStuart TurveyFurkan UddinMohammed UddinDiederik van de BeekDonald VinhMayana ZatzHelen SuJean-Laurent CasanovaSerge BureauYannick VacherAnne Gysembergh-HoualLauren DemervilleAbla ChachouaSebastien AbadRadhiya AbassiAbdelrafie AbdellaouiAbdelkrim AbdelmalekHendy AbdoulHelene AbergelFariza AbeudSophie AbgrallNoemie AbisrorMarylise AdechianNordine AderdourHakeem Farid AdmaneFrederic AdnetSara AfrittHelene AgostiniClaire AguilarSophie AgutTommaso Francesco AielloMarc Ait KaciHafid Ait OufellaGokula AjeenthiravasanVirginie AlauzyFanny Alby-LaurentLucie AllardMarie-Alexandra AlyanakianBlanca Amador BorreroSabrina AmamLucile AmroucheMarc AndronikofDany AnglicheauNadia AnguelDjillali AnnaneMohammed AounzouCaroline AparicioGladys AratusJean-Benoit ArletJeremy ArzoineElisabeth AslangulMona AssefiAdeline AubryLaetitia AudiffredEtienne AudureauChristelle Nathalie AugerJean-Charles AureganCeline AwotarSonia Ayllon MillaDelphine AzanLaurene AzemarBillal AzzouguenMarwa Bachir ElrufaaiAïda BadsiPrissile BakouboulaColine BalcerowiakFanta BaldeElodie BaldiviaEliane-Flore BangamingoAmandine BaptisteFanny Baran-MarszakCaroline BarauNathalie BargetFlore BaronnetRomain BarthelemyJean-Luc BaudelCamille BaudryElodie BaudryLaurent BeaugerieAdel BelamriNicolas BelaubeRhida BelilitaPierre BellassenRawan BelmokhtarIsabel BeltranRuben BenainousMourad BenallaouaRobert BenamouzigAmélie BenbaraJaouad BenhidaAnis BenkheloufJihene BenlaghaChahinez BenmostafaSkander BenothmaneMiassa BentifraouineLaurence BerardQuentin BernierEnora BertiAstrid BertierLaure BertonSimon BessisAlexandra BeurtonCeline BiancoClara BianquisFrank BidarPhilippe BlancheClarisse BlayauAlexandre BleibtreuEmmanuelle BlinCoralie Bloch-QueyratMarie-Christophe BoissierDiane BollensMarion BolzoniRudy Pierre BompardNicolas BonnetJustine BonnouvrierShirmonecrystal BothaWissam BoucennaFatiha BouchamaOlivier BouchaudHanane BouchghoulTaoueslylia BoudjeblaNoel BoudjemaCatherine BouffardAdrien BougleMeriem BouguerraLeila BourasAgnes BourcierAnne Bourgarit DurandAnne BourrierFabrice BouscaratDiane BouvryNesrine BouziriOns BouzraraSarah BribierDelphine BrugierMelanie BrunelEida BuiAnne BuissonIryna BukreyevaCôme BureauJacques CadranelJohann CailholRuxandra CalinClara Campos VegaPauline CanavaggioMarta CancellaDelphine CantinAlbert CaoLionel CarbillonNicolas CarlierClementine CassardGuylaine CastorMarion CauchyOlivier ChaBenjamin ChaigneSalima ChallalKarine ChampionPatrick ChariotJulie ChasSimon ChauveauAnthony ChauvinClement ChauvinNathalie ChavarotKamélia ChebboutMustapha CheraiIlaria CherubiniAmelie ChevalierThibault ChiarabiniThierry ChinetRichard ChocronPascaline ChoinierJuliette ChommelouxChristophe ChoquetLaure ChoupeauxBenjamin ChoustermanDragosmarius CiocanAda ClarkeGaëlle ClavereFlorian ClavierKarine ClementSebastien ClercYves CohenFleur CohenAdrien CohenAudrey CoillyHester ColbocPauline ColinMagalie ColletChloé ComarmondEmeline CombaconAlain CombesCeline ComparonJean-Michel ConstantinHugues CordelAnne-Gael CordierAdrien CostantiniNathalie Costedoat ChalumeauCamille CouffignalDoriane CoupeauAlain CreangeYannie Cuvillier LamarreCharlène da SilveiraSandrine Dautheville Guibal El KayaniNathalie de CastroYann De RyckeLucie del PozoQuentin DelannoyMathieu DelayRobin DelerisJuliette DelforgeLaëtitia DelphineNoemie DemareSophie DemeretAlexandre DemouleAurore DeniauFrançois DepretSophie DerolezOuda DerradjiNawal DerridjVincent DescampsLydia DeschampsCeline DesconcloisCyrielle DesnosKarine DesonginsRobin DhoteBenjamin DialloMorgane DidierMyriam DiemerStephane DiezJuliette Djadi-PratFatima-Zohra Djamouri MonnorySiham DjebaraNaoual DjebraMinette DjietcheuHadjer DjillaliNouara DjouadiSeverine DonnegerCatarina dos SantosNathalie DournonMartin DresLaura DroctoveMarie DrogreyMargot DropyElodie DrouetValérie DubosqEvelyne DubreucqEstelle DubusBoris DuchemannThibault DuchenoyEmmanuel DudoignonRomain DufauFlorence DumasClara DuranEmmanuelle DuronAntoine DurrbachClaudine DuvivierNathan EbsteinJihane El KhalifaAlexandre ElabbadiCaroline ElieGabriel ErnotteAnne EslingMartin EtienneXavier EyerMuriel Sarah FartoukhTakoua FayaliMarion FermautArianna FiorentinoSouha FlissMarie-Céline FournierBenjamin FournierHélène FrancoisOlivia FreynetYvann FrigoutIsaure FromontAxelle FuentesThomas FuretJoris GalandMarc GarnierAgnes GaubertStéphane GaudrySamuel GaugainDamien GauthierMaxime GautierSophie Georgin-LavialleDaniela GerominMohamed GhalayiniBijan GhalehMyriam GhezalAude GibelinLinda GimenoBenoit GirardBénédicte Giroux LeprieurDoryan GomesElisabete Gomes-PiresAnne GougeAmel GoujaHelene GouletSylvain GoupilJeanne Goupil de BouilleJulien GrasSegolene GreffeLamiae GrimaldiPaul GuedeneyBertrand GuidetMatthias GuilloMariechristelle GulczynskiTassadit HadjamDidier HaguenauerSoumeya HammalNadjib HammoudiOlivier HanonAnarole HarroisCoraline HautemGuillaume HekimianNicholas HemingOlivier HermineSylvie HoMarie HoullierBenjamin HuotTessa HuscenotWafa Ibn SaiedGhilas IkherbaneMeriem ImarazenePatrick IngilizLina IratniStephane JaureguiberryJean-Francois Jean-MarcDeleena JeyarajasinghamPauline JouanyVeronique JouisClement JourdaineOuifiya KafifRim KallalaSandrine KatsahianLilit KelesyanVixra KeoFlora KetzWarda KhamisEnfel KheliliMehdi KhellafChristy Gaëlla Kotokpo YoukouIlias KounisGaelle KpalmaJessica KrauseVincent LabbeKarine LacombeJean-Marc LacorteAnne Gaelle LafontEmmanuel LafontLynda LaghaLionel LamhautAymeric LancelotCecilia LandmanFanny LanternierCecile LarchevequeCaroline Lascoux CombeLudovic LasselBenjamin LaverdantChristophe LavergneJean-Rémi LavillegrandPompilia LazureanuLoïc Le GuennecLamia LeberreClaire LeblancMarion LeboyerFrancois LecomteMarine LecorreRomain LeenhardtMarylou LefebvreBénédicte LefebvrePaul LegendreAnne LegerLaurence LegrosJustyna LegrosseSébastien LehuunghiaJulien LemarecJeremie Leporrier-ExtManon LeseinHubert LesurVincent LevyAlbert LevyEdwige LopesAmanda LopesVanessa LopezJulien LopintoOlivier LortholaryBadr LouadahBénédicte LozeMarie-Laure LucasAxelle LucasamichiLiem Binh LuongArouna Magazimama-ExtDavid MaingretLakhdar MameriPhilippe ManivetCylia MansouriEstelle MarcaultJonathan MareyNathalie MarinClémence MaroisOlivier MartinLou MartineauCannelle Martinez-LopezPierre MartyniuckPauline Mary de FarcyNessrine MarzoukRafik MasmoudiAlexandre MebazaaFrédéric MechaiFabio MecozziChamseddine MediouniBruno MegarbaneMohamed MeghadechaÉlodie MejeanArsene MekinianNour Mekki AbdelhadiRania MekniThinhinan Sabrina MelitiBreno Melo LimaParis MengSoraya MerbahFadhila MessaniYasmine MessaoudiBaboo-Irwinsingh MewasingLydia MezianeCarole Michelot-BurgerFrançoise MignotFadi Hillary MinkaMakoto MiyaraPierre MoineJean-Michel MolinaAnaïs Montegnies-BouletAlexandra MontiClaire MontlahucAnne-Lise MontoutAlexandre MooresCaroline MorbieuHelene MorteletteStéphane MoulyRosita MuzaffarCherifa Iness NacerddineMarine NadalHajer NadifKladoum NassarmadjiPierre NatellaSandrine NdingamondzeStefan NeraalCaroline NguyenBao N’guyenIsabelle Nion LarmurierLuc NlomenyengueNicolas NoelHilario NunesEdris OmarZineb OuazeneElise OuedraogoWassila OuelaaAnissa OukhedoumaYasmina Ould AmaraHerve OyaJohanna OzielThomas PadillaElena PaillaudSolenne PaivaBeatrice ParfaitPerrine ParizeChristophe ParizotAntoine ParrotArthur PavotLaetitia PeaudecerfFrédéric PeneMarion PepinJulie PernetClaire PerninMylène PetitOlivier PeyronyMarie-Pierre PietriOlivia PietriMarc Pineton de ChambrunMichelle PinsonClaire PintadoValentine PiquardChristine PiresBenjamin PlanquetteSandrine PoirierAnne-Laure PomelStéphanie PonsDiane PonscarmeAnnegaelle PourcelotValérie PourcherAnne PouvaretFlorian PreverMiresta PrevilonMargot PrevostMarie-Julie ProvoostCyril QuemeneurCédric RafatAgathe RamiBrigitte RanqueMaurice RaphaelJean Herle RaphalenAnna RastoinMathieu RauxAmani RebaiMichael RebyAlexis RegentAsma RegragMatthieu Resche-RigonQuentin RessaireChristian RichardMariecaroline RichardMaxence RobertBenjamin RohautCamille Rolland-DebordJacques RopersAnne-Marie Roque-AfonsoCharlotte RossoMélanie RousseauxNabila RousseauxSwasti RouxLorène RouxClaire RouzaudAntoine RozesEmma RubensteinJean-Marc SabateSheila SabetSophie-Caroline SacleuxNathalie Saidenberg KermanachFaouzi SalibaDominique SalmonLaurent SavaleGuillaume SavaryRebecca SberroAnne ScemlaFrederic SchlemmerMathieu SchwartzSaïd SedfiSamia Sefir-KribelPhilippe SeksikPierre SellierAgathe SelvesNicole SembachLuca SemeranoMarie-Victoire SenatDamien SeneAlexandra SerrisLucile SeseNaima SghiouarJohanna SigauxMartin SiguierJohanne SilvainNoémie SimonTabassome SimonLina Innes SkandriMiassa SlimaniAurélie SnauwaertHarry SokolHeithem SolimanNisrine SoltaniBenjamin SoyerGabriel StegLydia SuarezTali-Anne SzwebelKossi TaffameClaire TantetMariagrazia TateoIgor TheodosePierre Clement ThiebaudCaroline ThomasKelly TierceletJulie TisserandCarole TomczakKrystel TorelinoFatima Touam-ExtLilia ToumiGustave TouryMireille Toy-MiouOlivia Tran Dinh Thanh LienAlexy TrandinhJean-Marc TreluyerBaptiste TrinqueJennifer TruchotSimone TunesiMatthieu TurpinAgathe TurpinTomas UrbinaRafael Usubillaga NarvaezYurdagul UzunhanPrabakar VaittinadaayarArnaud ValentMaelle ValentianNadia ValinHélène ValletMarina VazMiguel-Alejandro VazquezibarraBenoit VedieLaetitia VellyCeline VerstuyftCedric VialletteEric VicautDorothee VignesDamien VimpereMyriam VirlouvetGuillaume VoiriotLena VoisotEmmanuel WeissNicolas WeissAnaïs WinchenneYouri YordanovLara ZafraniMohamad ZaidanWissem ZaidiCathia ZakAida Zarhrate-GhoulOuassila ZatoutSuzanne ZeinoMichel ZeitouniNaïma ZemirliLorene ZerahOunsa ZiaMarianne ZiolOceane ZolarioJulien ZuberLaurent AbelClaire AndréjakFrançois AngoulvantDelphine BacheletMarie BartoliRomain BasmaciSylvie BehilillMarine BeluzeDehbia BenkerrouKrishna BhavsarLila BouadmaSabelline BouchezMaude BouscambertMinerva Cervantes-GonzalezAnissa ChairCatherine ChirouzeAlexandra CoelhoCamille CouffignalSandrine Couffin-CadierguesEric D’ortenzioMarie-Pierre DebrayLauren DeconinckDominique DeplanqueDiane DescampsMathilde DesvalléeAlpha DialloAlphonsine DioufCéline DorivalFrançois DubosXavier DuvalBrigitte ElharrarPhilippine EloyVincent EnoufHélène EsperouMarina Esposito-FareseManuel EtienneEglantine Ferrand DevougeNathalie GaultAlexandre GaymardJade GhosnTristan GiganteMorgane GilgJérémie GuedjAlexandre HoctinIsabelle HoffmannIkram HouasJean-Sébastien HulotSalma JaafouraOuifiya KafifFlorentia KaguelidouSabrina KaliAntoine KhalilCoralie KhanCédric LaouénanSamira LaribiMinh LeQuentin Le HingratSoizic Le MestreHervé Le NagardFrançois-Xavier LescureSophie LetrouYves LevyBruno LinaGuillaume LingasJean Christophe LucetDenis MalvyMarina MambertFrance MentréAmina MezianeHugo MouquetJimmy MullaertNadège NeantDuc NguyenMarion NoretSaad NseirAurélie PapadopoulosChristelle PaulNathan Peiffer-SmadjaThomas PerpointVentzislava Petrov-SanchezGilles PeytavinHuong PhamOlivier PiconeValentine PiquardOriane PuéchalChristian RabaudManuel Rosa-CalatravaBénédicte RossignolPatrick RossignolCarine RoyMarion SchneiderRicha SuCoralie TardivonMarie-Capucine TellierFrançois TéouléOlivier TerrierJean-François TimsitChristelle TualSylvie van der WerfNoémie VanelAurélie VeislingerBenoit VisseauxAurélie WiedemannYazdan YazdanpanahLoubna AlavoineSylvie BehillilCharles BurdetCharlotte CharpentierAline DechanetDiane DescampsXavier DuvalJean-Luc EcobichonVincent EnoufWahiba FrezoulsNadhira HouhouOuifiya KafifJonathan LehacautSophie LetrouBruno LinaJean-Christophe LucetPauline ManchonMariama NouroudineValentine PiquardCaroline QuintinMichael ThySylvie van der WerfValérie VignaliBenoit VisseauxYazdan YazdanpanahAbir ChahineNawal WaucquierMaria-Claire MigaudDominique DeplanqueFélix DjossouMayka Mergeay-FabreAude LucarelliMagalie DemarLéa BruneauPatrick GérardinAdrien MaillotChristine PayetBruno LaviolleFabrice LaineChristophe ParisMireille Desille-DugastJulie FouchardDenis MalvyDuc NguyenThierry PistonePauline PerreauValérie GissotCarole GoasSamatha MontagneLucie RichardCatherine ChirouzeKévin BouillerMaxime DesmaretsAlexandre MeunierMarilou BourgeonBenjamin LefévreHelene JeulinKarine LegrandSandra LomazziBernard TardyAmandine Gagneux-BrunonFrédérique BertholonElisabeth Botelho-NeversKouakam ChristelleLeturque NicolasLayidé RoufaiKarine AmatSandrine Couffin-CadierguesHélène EspérouSamia HendouGiuseppe FotiGiacomo BellaniGiuseppe CiterioErnesto ControAlberto PesciMaria Grazia ValsecchiMarina CazzanigaJorge AbadGiulia AccordinoCristian AchilleSergio Aguilera-AlbesaAina Aguiló-CucurullEsra Akyüz ÖzkanJonathan Antonio Roblero AlbisuresJuan AldaveMiquel Alfonso RamosTaj Ali KhanAnna AlibertiSeyed Alireza NadjiGulsum AlkanSuzan AlkhaterJerome Allardet-ServentMohammed AlshahraniLaia AlsinaMarie-Alexandra AlyanakianBlanca Amador BorreroZahir AmouraArnau AntolíRomain ArrestierMélodie AubartTeresa AuguetIryna AvramenkoGökhan AytekinAxelle AzotSeiamak BahramFanny BajolleFausto BaldantiAurélie BaldolliMaite BallesterHagit Baris FeldmanBenoit BarrouSabrina BassoGulsum Iclal BayhanAlexandre BelotLiliana BezrodnikAgurtzane BilbaoGeraldine Blanchard-RohnerIgnacio BlancoAdeline BlandinièresDaniel Blázquez-GameroAlexandre BleibtreuMarketa BloomfieldMireia Bolivar-PradosAnastasiia BondarenkoAlessandro BorghesiRaphael BorieElisabeth Botdhlo-NeversAhmed BousfihaAurore BousquetDavid BoutolleauClaire BouvattierOksana BoyarchukJuliette BravaisM. Luisa BrionesMarie-Eve BrunnerRaffaele BrunoMaria Rita P. BuenoHuda BukhariJacinta BustamanteJuan José Cáceres AgraRuggero CapraRaphael CarapitoMaria CarrabbaCarlos CasasnovasMarion CaserisIrene CassanitiMartin CastelleFrancesco CastelliMartín Castillo de VeraMateus CastroEmilie CatherinotJale Bengi CelikAlessandro CeschiMartin ChalumeauBruno CharbitMatthew ChengPère ClavéBonaventura ClotetAnna CodinaYves CohenCloé ComarmondAlain CombesPatrizia ComoliAngelo CorsicoBetul SozeriTaner CoşkunerAleksandar CvetkovskiCyril CyrusDavid DalmauFrançois DanionDavid Ross DarleyVincent DasNicolas DaubyStéphane DaugerPaul de MunterLoic de PontualAmin DehbanGeoffroy DelplancqAlexandre DemouleIsabelle DesguerreAntonio Di SabatinoJean-Luc DiehlStephanie DobbelaereElena Domínguez-GarridoClément DubostOlov EkwallŞefika Elmas BozdemirMarwa ElnagdyMelike EmirogluAkifumi EndoEmine Hafize ErdenizSelma Erol AytekinMaria Pilar Etxart LasaRomain EuvrardGiovanna FabioLaurence FaivreAntonin FalckMuriel FartoukhMorgane FaureMiguel Fernandez ArqueroRicard FerrerJose FerreresBruno FrancoisVictoria FumadóKitty FungFrancesca FuscoAlenka GagroBlanca Garcia SolisPierre GarçonPascale GaussemZeynep GayretliJuana Gil-HerreraLaurent GilardinAudrey Giraud GatineauMònica Girona-AlarcónKaren Alejandra Cifuentes GodínezJean-Christophe GoffardNacho GonzalesLuis Gonzalez-GranadoRafaela González-MontelongoAntoine GuerderBelgin GülhanVictor Daniel GumucioLeif Gunnar HanitschJan GunstJérôme HadjadjTetyana HariyanNevin HatipogluDeniz HeppekcanElisa Hernandez-BritoPo-Ki HoMaría Soledad Holanda-PeñaJuan HorcajadaSami HraiechLinda HumbertIvan HungAlejandro IglesiasAntonio Íñigo-CamposMatthieu JammeMaría Jesús ArranzMarie-Thérèse JimenoIolanda JordanSaliha Kanik-YüksekYalcin Burak KaraAydın KarahanKadriye Kart YasarOzgur KasapcopurKenichi KashimadaYasemin Kendir DemirkolYasutoshi KidoCan KizilAhmet Osman KılıçAdam KlocperkAntonia KoutsoukouZbigniew KrólHatem KsouriPaul KuentzArthur KwanYat Wah M. KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnes LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalSébastien VielCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessio FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie Cobat
• Organismes : Nutrition et obésités: approches systémiques (UMR-S 1269)
• Publié dans Genome Medicine le 24/10/2020

---

Résumé : Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7 , with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10 −4 ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10 −4 ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10 −3 ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10 −8 ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 −5 ). Conclusions Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Gregory SchwartzMichael SzarekVera BittnerRafael DiazShaun GoodmanJ Wouter JukemaUlf LandmesserPatricio López-JaramilloGaren ManvelianRobert PordyMichel ScemamaPeter SinnaeveHarvey WhitePhilippe Gabriel StegJ. Wouter JukemaP.H. Gabriel StegDeepak L BhattRobert HarringtonAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefWilliam SasielaJean-François TambyPhilip AylwardHeinz DrexelMirza DilicRenato LopesNina GotchevaJuan-Carlos PrietoHuo YongIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo Carlos Montenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisDavid MaronJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicEtienne PuymiratWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio O.E. BonoAdrian HrabarJulio VallejosRodolfo Ahuad GuerreroFederico NovoaCristian PatocchiCesar ZaidmanMaria GiulianoRicardo DranMarisa VicoGabriela CarneroPablo GuzmanJuan Medrano AllendeDaniela Garcia BrascaMiguel Bustamante LabartaSebastian NaniEduardo D.S. BlumbergHugo ColomboAlberto LibermanVictorino FuentealbaHector LuciardiGabriel WaismanMario BerliRuben Garcia DuranHoracio CestariHugo LuquezJorge GiordanoSilvia SaavedraGerardo ZapataOsvaldo CostamagnaSusana LloisJonathon WaitesNicholas CollinsAllan SowardChris L.S. HiiJames ShawMargaret ArstallJohn HorowitzDaniel NinioJames RogersDavid ColquhounRomulo Oqueli FloresPhilip Roberts-ThomsonOwen RaffelSam LehmanConstantine AroneySteven G.M. CoverdalePaul GarrahyGregory StarmerMark SaderPatrick CarrollRonald DickRobert ZweikerUta HoppeKurt HuberRudolf BergerGeorg Delle-KarthBernhard FreyDirk FaesKurt HermansBruno PirenneAttilio LeoneEtienne HofferMathias C.M. VrolixLuc de WolfBart WollaertMarc CastadotKarl DujardinChristophe BeauloyeGeert VervoortHarry StriekwoldCarl ConvensJohn RoosenEmanuele BarbatoMarc ClaeysFrank CoolsIbrahim TerzicFahir BarakovicZlatko MidzicBelma PojskicEmir FazlibegovicAzra Durak-NalbanticMehmed KulićDusko VulicAdis MuslibegovicBoris GoronjaGilmar ReisLuciano SousaJose NicolauFlavio GiorgetoRicardo SilvaLilia Nigro MaiaRafael RechPaulo R.F. RossiMaria José A.G. CerqueiraNorberto DudaRenato KalilAdrian KormannJosé Antonio M. AbrantesPedro Pimentel FilhoAna Priscila SoggiaMayler O.N. de SantosFernando NeuenschwanderLuiz BodaneseYorghos MichalarosFreddy EliaschewitzMaria VidottiPaulo LeaesRoberto BotelhoSergio KaiserEuler Roberto F. Fernandes ManentiDalton PrecomaJose Moura JorgePedro SilvaJose SilveiraWladmir SaporitoJose Marin NetoGilson FeitosaLuiz Eduardo F. RittJuliana de SouzaFernando CostaWeimar K.S.B. SouzaHelder J.L. ReisLeandro MachadoJosé Carlos Aidar AyoubGeorgi TodorovFedya NikolovElena VelchevaMaria TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva-PandevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodés-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi'An HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoWeiguo LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian'An WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora Molina de SalazarAlberto Cadena BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro Quintero OssaFernando Manzur JatinAristides Sotomayor HerazoJeffrey Castellanos ParadaRafael Suarez ArambulaMiguel Urina TrianaAngela Fernandez TrujilloMaja StrozziSiniša CarMelita JerićDavor MiličićMartina Lovrić BenčićHrvoje PintarićĐeiti PrvulovićJozica ŠikićViktor PeršićDean MiletaKresimir ŠtambukZdravko BabićVjekoslav TomulicJosip LukendaStanka Mejic-KrstulovicBoris StarcevicJindrich SpinarDavid HorakZdenek VelickaJosef StasekDavid AlanVilma MachovaAles LinhartVojtech NovotnyVladimir KaucakRichard RokytaRobert NaplavaZdenek CoufalVera AdamkovaIvo PodperaJiri ZizkaZuzana MotovskaIvana MarusincovaPremysl SvabPetr HeincJiri KucharPetr PovolnyJiri MatuskaSteen PoulsenBent RaungaardPeter ClemmensenLia BangOle MayMorten BøttcherJens HoveLars FrostGunnar GislasonJohn LarsenPeter Betton JohansenFlemming HaldPeter JohansenJørgen JeppesenTonny NielsenKjeld KristensenPiotr Maria WalichiewiczJens LomholdtIb KlausenPeter Kaiser NielsenFlemming DavidsenLars VidebaekMai SootsVeiko VahulaAnu HedmanÜllar SoopõldKaja MärtsinTiina JurgensonArved KristjanHeikki HuikuriJuhani Airaksinen Pierre CosteEmile FerrariOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinFlorence LeclercqAbdelkader BelhassaneNicolas DelarcheFranck BoccaraFranck PaganelliJérôme ClercFrancois SchieleVictor AboyansVincent ProbstJacques BerlandThierry LefèvreBernard CitronIrakli KhintibidzeTamaz ShaburishviliZurab PagavaRamaz GhlontiZaza LominadzeGeorge KhabeishviliRayyan HemetsbergerKemala EdwardUrsula Rauch-KröhnertMatthias StratmannKarl-Friedrich AppelEkkehard SchmidtHeyder OmranChristoph StellbrinkThomas DorselEmmanouil LianopoulosHans Friedrich VöhringerRoger MarxAndreas ZirlikDetlev SchellenbergThomas HeitzerUlrich LaufsChristian WernerStephan GielenSebastian NudingBernhard WinkelmannSteffen BehrensKarsten SydowMahir KarakasGregor SimonisThomas MuenzelNikos WernerStefan LeggewieDirk BöckerRüdiger Braun-DullaeusNicole ToursarkissianMichael JeserichMatthias WeissbrodtTim SchaeufeleJoachim WeilHeinz VöllerJohannes WaltenbergerMohammed NatourSusanne SchmittDirk Müller-WielandStephan SteinerLothar HeidenreichElmar OffersUwe GremmlerHolger KillatWerner RiekerSotiris PatsilinakosAthanasios KartalisAthanassios ManolisDimitrios SionisGeargios ChachalisIoannis SkoumasVasilios AthyrosPanagiotis VardasFrangkiskos ParthenakisJohn LekakisApostolos HatzitoliosSergio Fausto OvandoJuan Arango BeneckeEdgar Rodriguez de LeonBryan P.Y. YanDavid C.W. SiuTibor TuriBela MerkelyImre UngiGeza LupkovicsLajos NagyAndrás KatonaIstván ÉdesGábor MüllerIván HorvathTibor KapinZsolt SzigetiJózsef FaluközyMukund KumblaManjinder SandhuSharath AnnamNaveen Reddy ProdduturReddy RegellaRajendra PremchandAjaykumar MahajanSudhir PawarAtul AbhyanakarPrafulla KerkarRavishankar GovindaAbraham OommanDhurjati SinhaSachin PatilDhiman KahaliJitendra SawhneyAbhijeet JoshiSanjeev ChaudharyPankaj HarkutSantanu GuhaSanjay PorwalSrimannarayana JujjuruRamesh PothineniMinguel MonteiroAziz KhanShamanna IyengarJasprakash Singh GrewalManoj ChopdaMahesh FulwaniAparna PatangePatil SachinVijay ChopraNaresh GoyalRituparna ShindeGajendra ManaksheNitin PatkiSumeet SethiVengatesh MunusamySunil Karnaand Sunil ThanviSrilakshmi AdhyapakChandrakant PatilUlhas PandurangiRishabh MathurJugal GuptaSuhas KalashettiAjit BhagwatBagirath RaghuramanShiv Kumar YerraPrasant BhansaliRohidas BorsePatil RahulSrihari DasVinay KumarJabir AbdullakuttyShireesh SaathePriya PalimkarJabir AbdullkuttyShireesh SatheShaul AtarMichael ShechterMorris MosseriYaron ArbelChorin EhudHavakuk OferChaim LotanUri RosenscheinAmos KatzYaakov HenkinAdi FrancisMarc KlutsteinEugenia NikolskyRobert ZukermannYoav TurgemanMajdi HalabiAlon MarmorRan KornowskiMichael JonasOffer AmirYonathan HasinYoseph RozenmanShmuel FuchsVered ZviOsamah HusseinDov GavishZvi VeredYoseph CaracoMazen EliasNaveh TovEfrat WolfovitzMichael LishnerNizar EliasGiancarlo PiovaccariAnnamaria de PellegrinRaffaella GarbelottoGabriele GuardigliValgimigli MarcoGiovanni LicciardelloCarla AuguadroFilippo ScaliseClaudio CucciaAlessandro SalvioniGiuseppe MusumeciMichelle SenniPaolo CalabròSalvatore NovoPompilio FaggianoMarco MetraNicoletta de CesareSergio BertiClaudio CavalliniEnrico PuccioniMarcello GalvaniMaurizio TespiliPiermarco PiattiMichela PalvariniGiuseppe de LucaRoberto VioliniAlessandro de LeoZoran OlivariPasquale Perrone FilardiMaurizio FerratiniVittorio RaccaKazuoki DaiYuji ShimataniHaruo KamiyaKenji AndoYoshihiro TakedaYoshihiro MorinoYoshiki HataKazuo KimuraKoichi KishiIchiro MichishitaHiroki UeharaToshinori HigashikataAtsushi HirayamaKeiji HirookaYasuji DoiSatoru SakagamiShuichi TaguchiAkihiro KoikeHiroyuki FujinagaShinji KobaKen KozumaTomohiro KawasakiYujiro OnoMasatoshi ShimizuYousuke KatsudaAtsuyuki WadaToshiro ShinkeJunya AkoKenshi FujiiToshiyuki TakahashiTomohiro SakamotoKoichi NakaoYutaka FurukawaHiroshi SuginoRitsu TamuraToshiaki ManoMasaaki UematsuNoriaki UtsuKashima ItoTakuya HaraguchiKatsuhiko SatoYasunori UedaAkira NishibeKazuteru FujimotoMotomaru MasutaniJung Han YoonHack-Lyoung KimHun Sik ParkIn-Ho ChaeMoo Hyun KimMyung Ho JeongSeungwoon RhaChongjin KimHae Young KimTaekjong HongSeung-Jea TahkYoungkwon KimArija BusmaneNatalija PontagaAldis StrelnieksIveta MintaleIveta SimeZaneta PetrulionieneRoma KavaliauskieneRuta JurgaitieneGintare SakalyteRimvydas SlapikasSigute NorkieneNerijus MisonisAleksandras KibarskisRaimondas KubiliusStojko BojovskiNensi LozanceAleksandar KjovkaroskiSnezana DoncovskaTiong Kiam OngSazzli KasimOteh MaskonBalachandran KandasamyHoung LiewWan Mohd Izani Wan MohamedArmando García CastilloJorge Carrillo CalvilloPedro Fajardo CamposJuan Carlos Núñez FragosoEdmundo Alfredo Bayram LlamasMarco Antonio Alcocer GambaJaime Carranza MadrigalLuis Gerardo González SalasEnrique López RosasBelinda González DíazEduardo Salcido VázquezAlfredo Nacoud AckarGuillermo Antonio Llamas EsperónCarlos Rodolfo Martínez SánchezMaría Guerrero de LeonRodrigo Suarez OteroGuillermo Fanghänel SalmónJesús Antonio Pérez RíosJosé Angel Garza RuízRobert BreedveldMargriet Feenema-AardemaAlida Borger-van Der BurgPieter A.M. HoogslagHarry SuryapranataAntonius OomenPaulus van HaelstMargriet Feenema-ArademaJacobijne WiersmaDirk BasartRuud M.A. van Der WalPeter ZwartPascalle MonraatsHenricus van KesterenIoannis KaralisJohan JukemaGerardus J.E. VerdelBart R.G. BruerenRoland Pth TroquayEric ViergeverNadea Y.Y. Al-WindyGerard BartelsJan CornelWalter R.M. HermansJohannes P.R. HerrmanRobert BosReginald G.E.J. GroutarsCoenraad van Der ZwaanRefik KaplanRaymond LionaronsEelko RonnerBjorn GroenemeijerPatrick N.A. BronzwaerAnho A.H. LiemBernard J.W.M. RensingMarcel J.J.A. BokernRemco NijmeijerFerry M.R.J. HersbachFrank WillemsAntonius T.M. GosselinkSaman RasoulJohn ElliottGerard WilkinsRaewyn FisherMichael SchubnellHamish HartRalph StewartScott HardingIan TernouthNicholas FisherSamuel WilsonDenise AitkenRussell AnscombeLaura DavidsonTadeusz TomalaOttar NygårdJon Arne SparbyKjell AndersenLars GullestadJarle JortveitPeter MunkErlend Gyllensten SingsaasUlf HurtigJorge Calderon TiconaJulio Durand VelasquezSandra Negron MiguelEnrique Sanabria PerezJesus Carrion ChambillaCarlos Chavez AyalaReynaldo Castillo LeonRolando Vargas GonzalesJose Hernandez ZunigaLuis Camacho CosavalenteJorge Bravo MannucciJavier Heredia LandeoNassip Llerena NavarroYudy Roldan ConchaVíctor Rodriguez ChavezHenry Anchante HernandezCarlos Zea NunezWalter Mogrovejo RamosArthur FerrolinoRosa Allyn G. SyLouie TiradorGeneroso MatigaRaul Martin CochingAlisa BernanGregorio RogelioDante MoralesEdgar TanDennis Jose SulitAdrian WlodarczakKrystyna JaworskaGrzegorz SkoniecznyLidia PawlowiczPawel WojewodaBenita Busz-PapiezJanusz BednarskiAleksander GochPawel StanetaElzbieta DulakKrzysztof SaminskiWlodzimierz KrasowskiWanda SudnikAleksander ZurakowskiMarcin SkorskiRoman LysekBeata MiklaszewiczJacek KubicaJan Andrzej LipkoEdyta Kostarska-SrokoszMarek PiepiorkaAnna DrzewieckaRyszard SciborskiArkadiusz StasiewskiTomasz BlicharskiLeszek BystrykMichal SzpajerMarek KorolTomasz CzerskiEwa Mirek-BryniarskaJacek GniotAndrzej LubinskiJerzy GornyEdward FranekGrzegorz RaczakHanna SzwedPedro MonteiroJose Mesquita BastosHelder PereiraDinis MartinsFilipe SeixoCarlos MendonçaAna BotelhoFrancisca CaetanoBogdan MinescuOctavian IstratoaieDan TesloianuGabriel CristianSilviu DumitrescuCristian G.C. PodoleanuMircea C.A. ConstantinescuCristina BengusConstantin MilitaruDoina RosuIrinel ParepaAdrian MateiTom AlexandruMihaela MalisIoan ComanRodica Stanescu-CioranuDoina DimulescuYury ShvartsOlga OrlikovaZhanna KobalavaOlga BarbarashValentin MarkovNadezhda LyaminaAlexander GordienkoKonstantin ZrazhevskyAlexander VishnevskyVictor GurevichRaisa StryukNikita LomakinIgor BokarevTatiana KhlevchukSergey ShalaevLarisa KhaishevaPetr ChizhovInna ViktorovaNatalya OsokinaVladimir ShchekotovEvgenia AkatovaGalina ChumakovaIgor LibovMikhail VoevodaTatyana TretyakovaEvgeny BaranovSergey ShustovSergey YakushinIvan GordeevNiiaz KhasanovOlga ReshetkoTatiana SotnikovaOlga MolchanovaKonstantin NikolaevLiudmila GaponElena BaranovaZaur ShogenovElena KosmachovaYuriy KarpovAnton PovzunLiudmila EgorovaVadim TyrenkoIgor IvanovMasterov IlyaSergey KanorskyDragan SimicNikola IvanovicGoran DavidovicNebojsa TasicMilika AsaninStevo StojicSvetlana ApostolovicStevan IlicBiljana Putnikovic TosicAleksandar StankovicAleksandra ArandjelovicSlavica RadovanovicBranislava TodicJovan BalinovacDragan DincicPetar SeferovicAna KaradzicSlobodan DodicSinisa DimkovicTamara JakimovKian-Keong PohHean Yee OngJustin Tang I-ShingKarol MickoJan NociarDaniel PellaPeter FulopMarian HranaiJuraj PalkaJuraj MazurIvan MajercákAndrej DzupinaFrantišek FazekasJozef GonsorcikViliam BuganJuraj SeleckyGabriel KamenskyJaroslava StrbovaRudolf SmikAndrej DukatPeter OlexaIvan ŽuranJanez PoklukarNataša Černič ŠuligojMatija CevcHenry CysterNaresh RanjithClive CorbettJunaid BayatEllen Makoali MakotokoHendrik Du Toit TheronIlse KappMatthys de V BassonHanlie LotteringDina van AswegenLouis van ZylPeter SebastianThayabran PillayJan SaaimanPatrick CommerfordSoraya CassimjeeGarda RiazIftikhar EbrahimMahomed SarvanJoseph MynhardtHelmuth ReuterRajendran MoodleyManuel VidaAngel Cequier FillatVicente Bodí PerisFrancisco Fuentes JimenezFrancisco MarínJose Cruz FernándezRafael Jesus Hidalgo UrbanoBlas Gil-ExtremeraPablo ToledoFernando Worner DizDavid Garcia-DoradoAndres IñiguezJosé Tuñón FernándezJose Gonzalez-JuanateyJavier Fernandez PortalesFernando Civeira MurilloLaia Matas PericasJose Luis ZamoranoManuel de Mora MartinJordi Bruguera CortadaJoaquin Alonso MartinJose Maria Serrano AntolinJosé de Berrazueta FernándezJosé Antonio Vázquez de PradaJose Francisco Díaz FernándezJosé Alberto García LledóJuan Cosín SalesJavier Botas RodriguezGabriel Gusi TragantAmparo BenedictoCarlos Gonzalez-JuanateyMercedes Camprubí PotauIgnacio Plaza PerezCésar Morís de La TassaPablo Loma-Osorio RinconJavier Balaguer RecenaJuan EscudierAntonio Coca PayerasNorberto Alonso OrcajoPedro ValdivielsoGodwin ConstantineRuvaiz HaniffaNirmali TisseraStanley AmarasekeraChandrike PonnamperumaNimali FernandoKaputella FernandoJayanthimala JayawardenaSantharaj WijeyasingamGotabhaya RanasingheRuvan EkanayakaSepalika MendisVajira SenaratneGnanamoorthy MayurathanAjantha RajapakshaThilak SirisenaJagath HerathNaomali AmarasenaStefan BerglundGundars RasmanisOla VedinNils WittGeorgios MourtzinisPeter NicolOle HansenStefano RomeoSteen Agergaard JensenIngemar TorstenssonUlf AhremarkTorbjörn SundelinTiziano MoccettiFrancois MachRonald BindeOliver GämperliWei-Chuan TsaiKwo-Chang UengWen-Ter LaiMing-En LiuJuey-Jen HwangWei-Hsian YinI-Chang HsiehMing-Jer HsiehWei Hsiang LinJen-Yuan KuoTsuei-Yuan HuangChih-Yuan FangPinij KaewsuwannaWasant SoonfuangWoravut JintapakornApichard SukonthasarnNattawut WongpraparutKrisada SastravahaNakarin SansanayudhWirash KehasukcharoenDilok PiyayotaiPaiboon ChotnoparatpatAhmet CamsariHakan KultursayBulent MutluMurat ErsanliMustafa DemirtasCevat KirmaErtan UralLale KoldasOleksandr KarpenkoAlexander ProkhorovIhor VakaluykHalyna MyshanychDmytro ReshotkoValeriy BatushkinLeonid RudenkoIhor KovalskyiMykola KushnirVira TseluykoYuriy MostovoyMykola StanislavchukYulian KyiakYuriy KarpenkoYaroslav MalynovskyAndriy KlantsaOles KutniyEkaterina AmosovaViktor TashchukOleh LeshchukMykola RishkoMykola KopytsyaAndriy YagenskyMykola VatutinAndriy BagriyOlga BarnaOlexiy UshakovGeorgiy DzyakBorys GoloborodkoAnatolii RudenkoVolodymyr ZheleznyyJasper TrevelyanAzfar ZamanKaeng LeeAndrew MoriartyRajesh AggarwalPiers CliffordYuk-Ki WongSyed M.R. IqbalEduardas SubkovasDenise BraganzaDavid SarkarRobert StoreyHuw GriffithsSam McclureRangasamy MuthusamySimon SmithJohn KurianTerry LevyCraig BarrHoner KadrRobert GerberAudrius SimaitisHandrean SoranAnthony MathurAdrian BrodisonMohammad AyazMuhammad CheemaRichard OliverSimon ThackrayTelal MudawiGohar RahmanAyyaz SultanTimothy ReynoldsDavid SharmanDavid SprigingsRob ButlerPeter WilkinsonDavid FitzmauriceJulian HalcoxSean GallagherNicholas Ossei-GerningGil VardiDuccio BaldariDavid BrabhamCharles TreasureCharles DahlBruce PalmerAlan WisemanAbul KhanSanjeev PuriAnn Elizabeth MohartCarlos InceEnrique FloresScott WrightShi-Chi ChengMichael RosenbergWilliam RogersEdward KosinskiLes ForgoshJonathan WaltmanMisal KhanMohammad ShoukfehGeorges DagherPatrick CambierIra LieberPriya KumarCara EastPerry KrichmarMian HasanLindsey WhiteThomas KnickelbineThomas HaldisEve GillespieThomas AmidonDavid SuhImran ArifMouhamad AbdallahFaiq AkhterEric CarlsonMichael d'UrsoFadi El-AhdabWilliam NelsonKatie MoriartyBarry HarrisSteven CohenLuther CarterDaniel DotyKenneth SabatinoTariq HaddadAmir MalikSunder RaoAngel MulkayIon JovinKim KlanckeVinay MalhotraSai DevarapalliMichael KorenHarish ChandnaGeorge DoddsTauqir GorayaJames BengstonMatthew JanikJoseph MoranAndrew SumnerJohn KobayashiWilliam DavisShahram YazdaniJohn PasquiniMaitreya ThakkarAmarnath VedereWayne LeimbachJames RiderSarah FentonNarendra SinghAnil ShahDenise JanosikCarl PepineBrett BermanJoseph GelorminiChristopher DanielsKerensky RichardFriederike KeatingNicholas KondoSanjay ShettyHoward LeviteWinfried WaiderTheodore TakataMazen Abu-FadelVipul ShahRahul AggarwalMark IzzoAnil KumarBrack HattlerRose DoChad LinkAnna BortnickGeorge KinzfoglArnold GhitisJohn LarryEdward TeufelPeter KuhlmanBrent MclaurinWenwu ZhangStephen ThewJalal AbbasMatthew WhiteOthman IslamSumeet SubherwalNandkishore RanadiveBabak VakiliChristian GringDavid HendersonTimothy SchuchardNaim FarhatGeoffrey KlineSharan MahalJack WhitakerShawn SpeirsRolf AndersenNizar DaboulPhillip HorwitzFiras ZahrGeorge PonceZubair JafarJoseph McgarveyVipul PanchalStephen VoyceThomas BlokWilliam SheldonMasoud AzizadCarsten SchmalfussMark PiconeRobert PedersonWilliam HerzogKeith FriedmanJason LindseyRosemary NowinsEichenlaub TimothyParilak LeonardNorman LeporMahfouz El ShahawyHoward WeintraubAnand IrimpenAlvaro AlonsoWade MayDaniels ChristopherThomas GalskiAlan ChuFreny ModyEbrahimi RaminZachary HodesJoseph RossiGregory RoseJames FairlambCharles LambertAjit RaisinghaniAntonio AbbateGeorge VetrovecMarilyn KingCharles CareyJaime GerberLiwa YounisHyeun ParkMladen VidovichThomas KnutsonDennis FriedmanFred ChaleffArthur LoussararianPhillip RozemanCarey KimmelstielJeffrey KuvinKevin SilverMalcolm FosterGlen TonnessenAndrey EspinozaMohamadali AmlaniAndreas WaliChristopher MalozziGeert JongClara MasseyKeattiyoat WattanakitPhilip O'DonnellDinesh SingalNaseem JaffraniSridhar BanuruDaniel FisherMark XenakisNeal PerlmutterRavi BhagwatJames StraderRonald BlonderAyim Akyea-DjamsonAjay LabrooKwan LeeH. John MaraisEdmund ClaxtonRobert WeissRohr KathrynMartin BerkPeter RossiParag JoshiAmit KheraAjit KhairaGreg KumkumianSteven LupovitchJoshua PurowStephen WelkaDavid HoffmanStuart FischerEugene SorokaDonald EagertonSamir PancholyMichael RayNorman ErenrichMichael FarrarStewart PollockWilliam FrenchSteve DiamantisDouglas GuyLawrence GimpleMark NeustelSteven SchwartzEdward PereiraSeals AlbertDouglas SpriggsJanet StrainSuneet MittalAnthony VoMajed ChaneJason HallNampalli VijayKapildeo LotunF. Martin LesterAhed NahhasTheodore PopePaul NagerRakesh VohraMukesh SharmaRiyaz BashirHinan AhmedMichael BerlowitzRobert FishbergRobert BarruccoEric YangMichael RadinDaniel SpornDwight StapletonSteven EisenbergJoel LandzbergMartin McgoughSamir TurkMichael SchwartzP. Sandy SundramDiwakar JainMark ZaineaCarlos BayronRonald KarlsbergSuhail DohadHenry LuiWilliam KeenDonald WesterhausenSandeep KhuranaHimanshu AgarwalJessica BirchemWilliam PennyMark ChangSherrill MurphyJohn HenryBranislav Schifferdecker ;john M GilbertGopal ChalavaryaCharles EatonJohn SchmedtjeStuart ChristensonImran DotaniDouglas DenhamAlexander MacdonellPaul GibsonAref RahmanTammam Al JoundiNizar AssiGary ConradPurushotham KothaMichael LoveGregory GieslerHoward RubensteinDawood GamilLaura AkrightJustine KrawczykJoanne CoblerTerry WellsJames WelkerRobert FosterRichard GilmoreJay AndersonDouglas JacobyBill HarrisGeraldine GardnerRamprasad DandillayaKishor VoraJohn KostisJohn HunterDavid LaxsonEric BallFlavia EgydioAnelise KawakamiJanaina OliveiraJulianna WozniakAlexander MatthewsCaroline RatkyJanine ValirisLisa BerdanAnita HepditchKirby QuinteroTyrus RorickMelissa WestbrookAndrea PascualCarla RovitoMadeleine BezaultElodie DrouetTabassome SimonCaroline AlsweilerAnne LuytenJulie ButtersLiddy GriffithMichelle ShawLena GrunbergShahidul IslamMarie-France BrégeaultNathalie BougonDouglas FaustinoSylvie FontecaveJudith MurphyMelanie VerrierVéronique AgnettiDorthe AndersenEmmy BadreddineMhamed BekkoucheCecile BouancheauImane BriguiMaddy BrocklehurstJoseph CianciaruloDawn DevaulSzilvia DomokosCecile GacheCaroline GobillotSeverine GuillouJan HealyMegan HeathGayatri JaiwalCarine JavierreJulien LabeirieMyriam MonierUlises MoralesAsmaa MrabtiBicky MthombeniBetim OkanLucile SmithJennifer ShellerSebastien SopenaValerie PellanFadela BenbernouNafissa BengraitMaud LamoureuxKatarina KralovaRaphael BejuitAnthony CoulangeChristelle BerthouJérôme RepincayChristelle LorenzatoAlexis EtienneValerie GouetVirginie LoizeauMickael NormandAnne OurliacChristelle RondelAntony AdamoPascale BeltranPauline BarraudHelene Dubois-GacheBenjamin HalleLamia MetwallyMaxime MourguesMarc SottyMarion VincendetRaluca CotrutaZhu ChengyueDominique Fournie-LloretChristine MorrelloAurelie PerthuisPatrick PicaultIsabelle ZobouyanHelen ColhounMichael DempseyMark Mcclanahan
• Organismes : University of Colorado [Colorado Springs] State University of New York at New Paltz University of Alabama at Birmingham [ Birmingham] University of Toronto St. Michael's Hospital Leiden University Medical Center Charité - UniversitätsMedizin = Charité - University Hospital [Berlin] Berlin Institute of Health Universidad Autónoma de Bucaramanga Regeneron Pharmaceuticals [Tarrytown] Regeneron Pharmaceuticals [Tarrytown] SANOFI Recherche University Hospitals Leuven [Leuven] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Laboratoire de Recherche Vasculaire Translationnelle Royal Brompton Hospital Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Journal of the American College of Cardiology le 26/10/2020

---

Résumé : Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were ≥70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).

---

Source