Justine Paulus

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• Type de publi. : Article dans une revue
• Date de publi. : 03/08/2021
• Auteurs : Gregory SchwartzMichael SzarekVera BittnerRafael DiazShaun GoodmanJ Wouter JukemaUlf LandmesserPatricio López-JaramilloGaren ManvelianRobert PordyMichel ScemamaPeter SinnaeveHarvey WhitePhilippe Gabriel StegJ. Wouter JukemaP.H. Gabriel StegDeepak L BhattRobert HarringtonAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefWilliam SasielaJean-François TambyPhilip AylwardHeinz DrexelMirza DilicRenato LopesNina GotchevaJuan-Carlos PrietoHuo YongIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo Carlos Montenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisDavid MaronJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicEtienne PuymiratWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio JureJulio O.E. BonoAdrian HrabarJulio VallejosRodolfo Ahuad GuerreroFederico NovoaCristian PatocchiCesar ZaidmanMaria GiulianoRicardo DranMarisa VicoGabriela CarneroPablo GuzmanJuan Medrano AllendeDaniela Garcia BrascaMiguel Bustamante LabartaSebastian NaniEduardo D.S. BlumbergHugo ColomboAlberto LibermanVictorino FuentealbaHector LuciardiGabriel WaismanMario BerliRuben Garcia DuranHoracio CestariHugo LuquezJorge GiordanoSilvia SaavedraGerardo ZapataOsvaldo CostamagnaSusana LloisJonathon WaitesNicholas CollinsAllan SowardChris L.S. HiiJames ShawMargaret ArstallJohn HorowitzDaniel NinioJames RogersDavid ColquhounRomulo Oqueli FloresPhilip Roberts-ThomsonOwen RaffelSam LehmanConstantine AroneySteven G.M. CoverdalePaul GarrahyGregory StarmerMark SaderPatrick CarrollRonald DickRobert ZweikerUta HoppeKurt HuberRudolf BergerGeorg Delle-KarthBernhard FreyDirk FaesKurt HermansBruno PirenneAttilio LeoneEtienne HofferMathias C.M. VrolixLuc de WolfBart WollaertMarc CastadotKarl DujardinChristophe BeauloyeGeert VervoortHarry StriekwoldCarl ConvensJohn RoosenEmanuele BarbatoMarc ClaeysFrank CoolsIbrahim TerzicFahir BarakovicZlatko MidzicBelma PojskicEmir FazlibegovicAzra Durak-NalbanticMehmed KulićDusko VulicAdis MuslibegovicBoris GoronjaGilmar ReisLuciano SousaJose NicolauFlavio GiorgetoRicardo SilvaLilia Nigro MaiaRafael RechPaulo R.F. RossiMaria José A.G. CerqueiraNorberto DudaRenato KalilAdrian KormannJosé Antonio M. AbrantesPedro Pimentel FilhoAna Priscila SoggiaMayler O.N. de SantosFernando NeuenschwanderLuiz BodaneseYorghos MichalarosFreddy EliaschewitzMaria VidottiPaulo LeaesRoberto BotelhoSergio KaiserEuler Roberto F. Fernandes ManentiDalton PrecomaJose Moura JorgePedro SilvaJose SilveiraWladmir SaporitoJose Marin NetoGilson FeitosaLuiz Eduardo F. RittJuliana de SouzaFernando CostaWeimar K.S.B. SouzaHelder J.L. ReisLeandro MachadoJosé Carlos Aidar AyoubGeorgi TodorovFedya NikolovElena VelchevaMaria TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva-PandevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodés-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi'An HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoWeiguo LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian'An WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora Molina de SalazarAlberto Cadena BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro Quintero OssaFernando Manzur JatinAristides Sotomayor HerazoJeffrey Castellanos ParadaRafael Suarez ArambulaMiguel Urina TrianaAngela Fernandez TrujilloMaja StrozziSiniša CarMelita JerićDavor MiličićMartina Lovrić BenčićHrvoje PintarićĐeiti PrvulovićJozica ŠikićViktor PeršićDean MiletaKresimir ŠtambukZdravko BabićVjekoslav TomulicJosip LukendaStanka Mejic-KrstulovicBoris StarcevicJindrich SpinarDavid HorakZdenek VelickaJosef StasekDavid AlanVilma MachovaAles LinhartVojtech NovotnyVladimir KaucakRichard RokytaRobert NaplavaZdenek CoufalVera AdamkovaIvo PodperaJiri ZizkaZuzana MotovskaIvana MarusincovaPremysl SvabPetr HeincJiri KucharPetr PovolnyJiri MatuskaSteen PoulsenBent RaungaardPeter ClemmensenLia BangOle MayMorten BøttcherJens HoveLars FrostGunnar GislasonJohn LarsenPeter Betton JohansenFlemming HaldPeter JohansenJørgen JeppesenTonny NielsenKjeld KristensenPiotr Maria WalichiewiczJens LomholdtIb KlausenPeter Kaiser NielsenFlemming DavidsenLars VidebaekMai SootsVeiko VahulaAnu HedmanÜllar SoopõldKaja MärtsinTiina JurgensonArved KristjanHeikki HuikuriJuhani Airaksinen Pierre CosteEmile FerrariOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinFlorence LeclercqAbdelkader BelhassaneNicolas DelarcheFranck BoccaraFranck PaganelliJérôme ClercFrancois SchieleVictor AboyansVincent ProbstJacques BerlandThierry LefèvreBernard CitronIrakli KhintibidzeTamaz ShaburishviliZurab PagavaRamaz GhlontiZaza LominadzeGeorge KhabeishviliRayyan HemetsbergerKemala EdwardUrsula Rauch-KröhnertMatthias StratmannKarl-Friedrich AppelEkkehard SchmidtHeyder OmranChristoph StellbrinkThomas DorselEmmanouil LianopoulosHans Friedrich VöhringerRoger MarxAndreas ZirlikDetlev SchellenbergThomas HeitzerUlrich LaufsChristian WernerStephan GielenSebastian NudingBernhard WinkelmannSteffen BehrensKarsten SydowMahir KarakasGregor SimonisThomas MuenzelNikos WernerStefan LeggewieDirk BöckerRüdiger Braun-DullaeusNicole ToursarkissianMichael JeserichMatthias WeissbrodtTim SchaeufeleJoachim WeilHeinz VöllerJohannes WaltenbergerMohammed NatourSusanne SchmittDirk Müller-WielandStephan SteinerLothar HeidenreichElmar OffersUwe GremmlerHolger KillatWerner RiekerSotiris PatsilinakosAthanasios KartalisAthanassios ManolisDimitrios SionisGeargios ChachalisIoannis SkoumasVasilios AthyrosPanagiotis VardasFrangkiskos ParthenakisJohn LekakisApostolos HatzitoliosSergio Fausto OvandoJuan Arango BeneckeEdgar Rodriguez de LeonBryan P.Y. YanDavid C.W. SiuTibor TuriBela MerkelyImre UngiGeza LupkovicsLajos NagyAndrás KatonaIstván ÉdesGábor MüllerIván HorvathTibor KapinZsolt SzigetiJózsef FaluközyMukund KumblaManjinder SandhuSharath AnnamNaveen Reddy ProdduturReddy RegellaRajendra PremchandAjaykumar MahajanSudhir PawarAtul AbhyanakarPrafulla KerkarRavishankar GovindaAbraham OommanDhurjati SinhaSachin PatilDhiman KahaliJitendra SawhneyAbhijeet JoshiSanjeev ChaudharyPankaj HarkutSantanu GuhaSanjay PorwalSrimannarayana JujjuruRamesh PothineniMinguel MonteiroAziz KhanShamanna IyengarJasprakash Singh GrewalManoj ChopdaMahesh FulwaniAparna PatangePatil SachinVijay ChopraNaresh GoyalRituparna ShindeGajendra ManaksheNitin PatkiSumeet SethiVengatesh MunusamySunil Karnaand Sunil ThanviSrilakshmi AdhyapakChandrakant PatilUlhas PandurangiRishabh MathurJugal GuptaSuhas KalashettiAjit BhagwatBagirath RaghuramanShiv Kumar YerraPrasant BhansaliRohidas BorsePatil RahulSrihari DasVinay KumarJabir AbdullakuttyShireesh SaathePriya PalimkarJabir AbdullkuttyShireesh SatheShaul AtarMichael ShechterMorris MosseriYaron ArbelChorin EhudHavakuk OferChaim LotanUri RosenscheinAmos KatzYaakov HenkinAdi FrancisMarc KlutsteinEugenia NikolskyRobert ZukermannYoav TurgemanMajdi HalabiAlon MarmorRan KornowskiMichael JonasOffer AmirYonathan HasinYoseph RozenmanShmuel FuchsVered ZviOsamah HusseinDov GavishZvi VeredYoseph CaracoMazen EliasNaveh TovEfrat WolfovitzMichael LishnerNizar EliasGiancarlo PiovaccariAnnamaria de PellegrinRaffaella GarbelottoGabriele GuardigliValgimigli MarcoGiovanni LicciardelloCarla AuguadroFilippo ScaliseClaudio CucciaAlessandro SalvioniGiuseppe MusumeciMichelle SenniPaolo CalabròSalvatore NovoPompilio FaggianoMarco MetraNicoletta de CesareSergio BertiClaudio CavalliniEnrico PuccioniMarcello GalvaniMaurizio TespiliPiermarco PiattiMichela PalvariniGiuseppe de LucaRoberto VioliniAlessandro de LeoZoran OlivariPasquale Perrone FilardiMaurizio FerratiniVittorio RaccaKazuoki DaiYuji ShimataniHaruo KamiyaKenji AndoYoshihiro TakedaYoshihiro MorinoYoshiki HataKazuo KimuraKoichi KishiIchiro MichishitaHiroki UeharaToshinori HigashikataAtsushi HirayamaKeiji HirookaYasuji DoiSatoru SakagamiShuichi TaguchiAkihiro KoikeHiroyuki FujinagaShinji KobaKen KozumaTomohiro KawasakiYujiro OnoMasatoshi ShimizuYousuke KatsudaAtsuyuki WadaToshiro ShinkeJunya AkoKenshi FujiiToshiyuki TakahashiTomohiro SakamotoKoichi NakaoYutaka FurukawaHiroshi SuginoRitsu TamuraToshiaki ManoMasaaki UematsuNoriaki UtsuKashima ItoTakuya HaraguchiKatsuhiko SatoYasunori UedaAkira NishibeKazuteru FujimotoMotomaru MasutaniJung Han YoonHack-Lyoung KimHun Sik ParkIn-Ho ChaeMoo Hyun KimMyung Ho JeongSeungwoon RhaChongjin KimHae Young KimTaekjong HongSeung-Jea TahkYoungkwon KimArija BusmaneNatalija PontagaAldis StrelnieksIveta MintaleIveta SimeZaneta PetrulionieneRoma KavaliauskieneRuta JurgaitieneGintare SakalyteRimvydas SlapikasSigute NorkieneNerijus MisonisAleksandras KibarskisRaimondas KubiliusStojko BojovskiNensi LozanceAleksandar KjovkaroskiSnezana DoncovskaTiong Kiam OngSazzli KasimOteh MaskonBalachandran KandasamyHoung LiewWan Mohd Izani Wan MohamedArmando García CastilloJorge Carrillo CalvilloPedro Fajardo CamposJuan Carlos Núñez FragosoEdmundo Alfredo Bayram LlamasMarco Antonio Alcocer GambaJaime Carranza MadrigalLuis Gerardo González SalasEnrique López RosasBelinda González DíazEduardo Salcido VázquezAlfredo Nacoud AckarGuillermo Antonio Llamas EsperónCarlos Rodolfo Martínez SánchezMaría Guerrero de LeonRodrigo Suarez OteroGuillermo Fanghänel SalmónJesús Antonio Pérez RíosJosé Angel Garza RuízRobert BreedveldMargriet Feenema-AardemaAlida Borger-van Der BurgPieter A.M. HoogslagHarry SuryapranataAntonius OomenPaulus van HaelstMargriet Feenema-ArademaJacobijne WiersmaDirk BasartRuud M.A. van Der WalPeter ZwartPascalle MonraatsHenricus van KesterenIoannis KaralisJohan JukemaGerardus J.E. VerdelBart R.G. BruerenRoland Pth TroquayEric ViergeverNadea Y.Y. Al-WindyGerard BartelsJan CornelWalter R.M. HermansJohannes P.R. HerrmanRobert BosReginald G.E.J. GroutarsCoenraad van Der ZwaanRefik KaplanRaymond LionaronsEelko RonnerBjorn GroenemeijerPatrick N.A. BronzwaerAnho A.H. LiemBernard J.W.M. RensingMarcel J.J.A. BokernRemco NijmeijerFerry M.R.J. HersbachFrank WillemsAntonius T.M. GosselinkSaman RasoulJohn ElliottGerard WilkinsRaewyn FisherMichael SchubnellHamish HartRalph StewartScott HardingIan TernouthNicholas FisherSamuel WilsonDenise AitkenRussell AnscombeLaura DavidsonTadeusz TomalaOttar NygårdJon Arne SparbyKjell AndersenLars GullestadJarle JortveitPeter MunkErlend Gyllensten SingsaasUlf HurtigJorge Calderon TiconaJulio Durand VelasquezSandra Negron MiguelEnrique Sanabria PerezJesus Carrion ChambillaCarlos Chavez AyalaReynaldo Castillo LeonRolando Vargas GonzalesJose Hernandez ZunigaLuis Camacho CosavalenteJorge Bravo MannucciJavier Heredia LandeoNassip Llerena NavarroYudy Roldan ConchaVíctor Rodriguez ChavezHenry Anchante HernandezCarlos Zea NunezWalter Mogrovejo RamosArthur FerrolinoRosa Allyn G. SyLouie TiradorGeneroso MatigaRaul Martin CochingAlisa BernanGregorio RogelioDante MoralesEdgar TanDennis Jose SulitAdrian WlodarczakKrystyna JaworskaGrzegorz SkoniecznyLidia PawlowiczPawel WojewodaBenita Busz-PapiezJanusz BednarskiAleksander GochPawel StanetaElzbieta DulakKrzysztof SaminskiWlodzimierz KrasowskiWanda SudnikAleksander ZurakowskiMarcin SkorskiRoman LysekBeata MiklaszewiczJacek KubicaJan Andrzej LipkoEdyta Kostarska-SrokoszMarek PiepiorkaAnna DrzewieckaRyszard SciborskiArkadiusz StasiewskiTomasz BlicharskiLeszek BystrykMichal SzpajerMarek KorolTomasz CzerskiEwa Mirek-BryniarskaJacek GniotAndrzej LubinskiJerzy GornyEdward FranekGrzegorz RaczakHanna SzwedPedro MonteiroJose Mesquita BastosHelder PereiraDinis MartinsFilipe SeixoCarlos MendonçaAna BotelhoFrancisca CaetanoBogdan MinescuOctavian IstratoaieDan TesloianuGabriel CristianSilviu DumitrescuCristian G.C. PodoleanuMircea C.A. ConstantinescuCristina BengusConstantin MilitaruDoina RosuIrinel ParepaAdrian MateiTom AlexandruMihaela MalisIoan ComanRodica Stanescu-CioranuDoina DimulescuYury ShvartsOlga OrlikovaZhanna KobalavaOlga BarbarashValentin MarkovNadezhda LyaminaAlexander GordienkoKonstantin ZrazhevskyAlexander VishnevskyVictor GurevichRaisa StryukNikita LomakinIgor BokarevTatiana KhlevchukSergey ShalaevLarisa KhaishevaPetr ChizhovInna ViktorovaNatalya OsokinaVladimir ShchekotovEvgenia AkatovaGalina ChumakovaIgor LibovMikhail VoevodaTatyana TretyakovaEvgeny BaranovSergey ShustovSergey YakushinIvan GordeevNiiaz KhasanovOlga ReshetkoTatiana SotnikovaOlga MolchanovaKonstantin NikolaevLiudmila GaponElena BaranovaZaur ShogenovElena KosmachovaYuriy KarpovAnton PovzunLiudmila EgorovaVadim TyrenkoIgor IvanovMasterov IlyaSergey KanorskyDragan SimicNikola IvanovicGoran DavidovicNebojsa TasicMilika AsaninStevo StojicSvetlana ApostolovicStevan IlicBiljana Putnikovic TosicAleksandar StankovicAleksandra ArandjelovicSlavica RadovanovicBranislava TodicJovan BalinovacDragan DincicPetar SeferovicAna KaradzicSlobodan DodicSinisa DimkovicTamara JakimovKian-Keong PohHean Yee OngJustin Tang I-ShingKarol MickoJan NociarDaniel PellaPeter FulopMarian HranaiJuraj PalkaJuraj MazurIvan MajercákAndrej DzupinaFrantišek FazekasJozef GonsorcikViliam BuganJuraj SeleckyGabriel KamenskyJaroslava StrbovaRudolf SmikAndrej DukatPeter OlexaIvan ŽuranJanez PoklukarNataša Černič ŠuligojMatija CevcHenry CysterNaresh RanjithClive CorbettJunaid BayatEllen Makoali MakotokoHendrik Du Toit TheronIlse KappMatthys de V BassonHanlie LotteringDina van AswegenLouis van ZylPeter SebastianThayabran PillayJan SaaimanPatrick CommerfordSoraya CassimjeeGarda RiazIftikhar EbrahimMahomed SarvanJoseph MynhardtHelmuth ReuterRajendran MoodleyManuel VidaAngel Cequier FillatVicente Bodí PerisFrancisco Fuentes JimenezFrancisco MarínJose Cruz FernándezRafael Jesus Hidalgo UrbanoBlas Gil-ExtremeraPablo ToledoFernando Worner DizDavid Garcia-DoradoAndres IñiguezJosé Tuñón FernándezJose Gonzalez-JuanateyJavier Fernandez PortalesFernando Civeira MurilloLaia Matas PericasJose Luis ZamoranoManuel de Mora MartinJordi Bruguera CortadaJoaquin Alonso MartinJose Maria Serrano AntolinJosé de Berrazueta FernándezJosé Antonio Vázquez de PradaJose Francisco Díaz FernándezJosé Alberto García LledóJuan Cosín SalesJavier Botas RodriguezGabriel Gusi TragantAmparo BenedictoCarlos Gonzalez-JuanateyMercedes Camprubí PotauIgnacio Plaza PerezCésar Morís de La TassaPablo Loma-Osorio RinconJavier Balaguer RecenaJuan EscudierAntonio Coca PayerasNorberto Alonso OrcajoPedro ValdivielsoGodwin ConstantineRuvaiz HaniffaNirmali TisseraStanley AmarasekeraChandrike PonnamperumaNimali FernandoKaputella FernandoJayanthimala JayawardenaSantharaj WijeyasingamGotabhaya RanasingheRuvan EkanayakaSepalika MendisVajira SenaratneGnanamoorthy MayurathanAjantha RajapakshaThilak SirisenaJagath HerathNaomali AmarasenaStefan BerglundGundars RasmanisOla VedinNils WittGeorgios MourtzinisPeter NicolOle HansenStefano RomeoSteen Agergaard JensenIngemar TorstenssonUlf AhremarkTorbjörn SundelinTiziano MoccettiFrancois MachRonald BindeOliver GämperliWei-Chuan TsaiKwo-Chang UengWen-Ter LaiMing-En LiuJuey-Jen HwangWei-Hsian YinI-Chang HsiehMing-Jer HsiehWei Hsiang LinJen-Yuan KuoTsuei-Yuan HuangChih-Yuan FangPinij KaewsuwannaWasant SoonfuangWoravut JintapakornApichard SukonthasarnNattawut WongpraparutKrisada SastravahaNakarin SansanayudhWirash KehasukcharoenDilok PiyayotaiPaiboon ChotnoparatpatAhmet CamsariHakan KultursayBulent MutluMurat ErsanliMustafa DemirtasCevat KirmaErtan UralLale KoldasOleksandr KarpenkoAlexander ProkhorovIhor VakaluykHalyna MyshanychDmytro ReshotkoValeriy BatushkinLeonid RudenkoIhor KovalskyiMykola KushnirVira TseluykoYuriy MostovoyMykola StanislavchukYulian KyiakYuriy KarpenkoYaroslav MalynovskyAndriy KlantsaOles KutniyEkaterina AmosovaViktor TashchukOleh LeshchukMykola RishkoMykola KopytsyaAndriy YagenskyMykola VatutinAndriy BagriyOlga BarnaOlexiy UshakovGeorgiy DzyakBorys GoloborodkoAnatolii RudenkoVolodymyr ZheleznyyJasper TrevelyanAzfar ZamanKaeng LeeAndrew MoriartyRajesh AggarwalPiers CliffordYuk-Ki WongSyed M.R. IqbalEduardas SubkovasDenise BraganzaDavid SarkarRobert StoreyHuw GriffithsSam McclureRangasamy MuthusamySimon SmithJohn KurianTerry LevyCraig BarrHoner KadrRobert GerberAudrius SimaitisHandrean SoranAnthony MathurAdrian BrodisonMohammad AyazMuhammad CheemaRichard OliverSimon ThackrayTelal MudawiGohar RahmanAyyaz SultanTimothy ReynoldsDavid SharmanDavid SprigingsRob ButlerPeter WilkinsonDavid FitzmauriceJulian HalcoxSean GallagherNicholas Ossei-GerningGil VardiDuccio BaldariDavid BrabhamCharles TreasureCharles DahlBruce PalmerAlan WisemanAbul KhanSanjeev PuriAnn Elizabeth MohartCarlos InceEnrique FloresScott WrightShi-Chi ChengMichael RosenbergWilliam RogersEdward KosinskiLes ForgoshJonathan WaltmanMisal KhanMohammad ShoukfehGeorges DagherPatrick CambierIra LieberPriya KumarCara EastPerry KrichmarMian HasanLindsey WhiteThomas KnickelbineThomas HaldisEve GillespieThomas AmidonDavid SuhImran ArifMouhamad AbdallahFaiq AkhterEric CarlsonMichael d'UrsoFadi El-AhdabWilliam NelsonKatie MoriartyBarry HarrisSteven CohenLuther CarterDaniel DotyKenneth SabatinoTariq HaddadAmir MalikSunder RaoAngel MulkayIon JovinKim KlanckeVinay MalhotraSai DevarapalliMichael KorenHarish ChandnaGeorge DoddsTauqir GorayaJames BengstonMatthew JanikJoseph MoranAndrew SumnerJohn KobayashiWilliam DavisShahram YazdaniJohn PasquiniMaitreya ThakkarAmarnath VedereWayne LeimbachJames RiderSarah FentonNarendra SinghAnil ShahDenise JanosikCarl PepineBrett BermanJoseph GelorminiChristopher DanielsKerensky RichardFriederike KeatingNicholas KondoSanjay ShettyHoward LeviteWinfried WaiderTheodore TakataMazen Abu-FadelVipul ShahRahul AggarwalMark IzzoAnil KumarBrack HattlerRose DoChad LinkAnna BortnickGeorge KinzfoglArnold GhitisJohn LarryEdward TeufelPeter KuhlmanBrent MclaurinWenwu ZhangStephen ThewJalal AbbasMatthew WhiteOthman IslamSumeet SubherwalNandkishore RanadiveBabak VakiliChristian GringDavid HendersonTimothy SchuchardNaim FarhatGeoffrey KlineSharan MahalJack WhitakerShawn SpeirsRolf AndersenNizar DaboulPhillip HorwitzFiras ZahrGeorge PonceZubair JafarJoseph McgarveyVipul PanchalStephen VoyceThomas BlokWilliam SheldonMasoud AzizadCarsten SchmalfussMark PiconeRobert PedersonWilliam HerzogKeith FriedmanJason LindseyRosemary NowinsEichenlaub TimothyParilak LeonardNorman LeporMahfouz El ShahawyHoward WeintraubAnand IrimpenAlvaro AlonsoWade MayDaniels ChristopherThomas GalskiAlan ChuFreny ModyEbrahimi RaminZachary HodesJoseph RossiGregory RoseJames FairlambCharles LambertAjit RaisinghaniAntonio AbbateGeorge VetrovecMarilyn KingCharles CareyJaime GerberLiwa YounisHyeun ParkMladen VidovichThomas KnutsonDennis FriedmanFred ChaleffArthur LoussararianPhillip RozemanCarey KimmelstielJeffrey KuvinKevin SilverMalcolm FosterGlen TonnessenAndrey EspinozaMohamadali AmlaniAndreas WaliChristopher MalozziGeert JongClara MasseyKeattiyoat WattanakitPhilip O'DonnellDinesh SingalNaseem JaffraniSridhar BanuruDaniel FisherMark XenakisNeal PerlmutterRavi BhagwatJames StraderRonald BlonderAyim Akyea-DjamsonAjay LabrooKwan LeeH. John MaraisEdmund ClaxtonRobert WeissRohr KathrynMartin BerkPeter RossiParag JoshiAmit KheraAjit KhairaGreg KumkumianSteven LupovitchJoshua PurowStephen WelkaDavid HoffmanStuart FischerEugene SorokaDonald EagertonSamir PancholyMichael RayNorman ErenrichMichael FarrarStewart PollockWilliam FrenchSteve DiamantisDouglas GuyLawrence GimpleMark NeustelSteven SchwartzEdward PereiraSeals AlbertDouglas SpriggsJanet StrainSuneet MittalAnthony VoMajed ChaneJason HallNampalli VijayKapildeo LotunF. Martin LesterAhed NahhasTheodore PopePaul NagerRakesh VohraMukesh SharmaRiyaz BashirHinan AhmedMichael BerlowitzRobert FishbergRobert BarruccoEric YangMichael RadinDaniel SpornDwight StapletonSteven EisenbergJoel LandzbergMartin McgoughSamir TurkMichael SchwartzP. Sandy SundramDiwakar JainMark ZaineaCarlos BayronRonald KarlsbergSuhail DohadHenry LuiWilliam KeenDonald WesterhausenSandeep KhuranaHimanshu AgarwalJessica BirchemWilliam PennyMark ChangSherrill MurphyJohn HenryBranislav Schifferdecker ;john M GilbertGopal ChalavaryaCharles EatonJohn SchmedtjeStuart ChristensonImran DotaniDouglas DenhamAlexander MacdonellPaul GibsonAref RahmanTammam Al JoundiNizar AssiGary ConradPurushotham KothaMichael LoveGregory GieslerHoward RubensteinDawood GamilLaura AkrightJustine KrawczykJoanne CoblerTerry WellsJames WelkerRobert FosterRichard GilmoreJay AndersonDouglas JacobyBill HarrisGeraldine GardnerRamprasad DandillayaKishor VoraJohn KostisJohn HunterDavid LaxsonEric BallFlavia EgydioAnelise KawakamiJanaina OliveiraJulianna WozniakAlexander MatthewsCaroline RatkyJanine ValirisLisa BerdanAnita HepditchKirby QuinteroTyrus RorickMelissa WestbrookAndrea PascualCarla RovitoMadeleine BezaultElodie DrouetTabassome SimonCaroline AlsweilerAnne LuytenJulie ButtersLiddy GriffithMichelle ShawLena GrunbergShahidul IslamMarie-France BrégeaultNathalie BougonDouglas FaustinoSylvie FontecaveJudith MurphyMelanie VerrierVéronique AgnettiDorthe AndersenEmmy BadreddineMhamed BekkoucheCecile BouancheauImane BriguiMaddy BrocklehurstJoseph CianciaruloDawn DevaulSzilvia DomokosCecile GacheCaroline GobillotSeverine GuillouJan HealyMegan HeathGayatri JaiwalCarine JavierreJulien LabeirieMyriam MonierUlises MoralesAsmaa MrabtiBicky MthombeniBetim OkanLucile SmithJennifer ShellerSebastien SopenaValerie PellanFadela BenbernouNafissa BengraitMaud LamoureuxKatarina KralovaRaphael BejuitAnthony CoulangeChristelle BerthouJérôme RepincayChristelle LorenzatoAlexis EtienneValerie GouetVirginie LoizeauMickael NormandAnne OurliacChristelle RondelAntony AdamoPascale BeltranPauline BarraudHelene Dubois-GacheBenjamin HalleLamia MetwallyMaxime MourguesMarc SottyMarion VincendetRaluca CotrutaZhu ChengyueDominique Fournie-LloretChristine MorrelloAurelie PerthuisPatrick PicaultIsabelle ZobouyanHelen ColhounMichael DempseyMark Mcclanahan
• Organismes : University of Colorado [Colorado Springs] State University of New York at New Paltz University of Alabama at Birmingham [ Birmingham] University of Toronto St. Michael's Hospital Leiden University Medical Center (LUMC) Charité - UniversitätsMedizin = Charité - University Hospital [Berlin] Berlin Institute of Health Universidad Autónoma de Bucaramanga Regeneron Pharmaceuticals [Tarrytown] Regeneron Pharmaceuticals [Tarrytown] SANOFI Recherche University Hospitals Leuven [Leuven] Alliance française pour les essais cliniques cardio-vasculaires - French Alliance for Cardiovascular Trials Laboratoire de Recherche Vasculaire Translationnelle Royal Brompton Hospital Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier
• Publié dans Journal of the American College of Cardiology le 26/10/2020

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Résumé : Background: Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. Objectives: In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, the authors evaluated the benefit of adding the proprotein subtilisin/kexin type 9 inhibitor alirocumab to optimized statin treatment in patients with LDL-C levels near 70 mg/dL. Effects were evaluated according to concurrent lipoprotein(a) levels. Methods: ODYSSEY Outcomes compared alirocumab with placebo in 18,924 patients with recent acute coronary syndromes receiving optimized statin treatment. In 4,351 patients (23.0%), screening or randomization LDL-C was <70 mg/dL (median 69.4 mg/dL; interquartile range: 64.3-74.0 mg/dL); in 14,573 patients (77.0%), both determinations were ≥70 mg/dL (median 94.0 mg/dL; interquartile range: 83.2-111.0 mg/dL). Results: In the lower LDL-C subgroup, MACE rates were 4.2 and 3.1 per 100 patient-years among placebo-treated patients with baseline lipoprotein(a) greater than or less than or equal to the median (13.7 mg/dL). Corresponding adjusted treatment hazard ratios were 0.68 (95% confidence interval [CI]: 0.52-0.90) and 1.11 (95% CI: 0.83-1.49), with treatment-lipoprotein(a) interaction on MACE (Pinteraction = 0.017). In the higher LDL-C subgroup, MACE rates were 4.7 and 3.8 per 100 patient-years among placebo-treated patients with lipoprotein(a) >13.7 mg/dL or ≤13.7 mg/dL; corresponding adjusted treatment hazard ratios were 0.82 (95% CI: 0.72-0.92) and 0.89 (95% CI: 0.75-1.06), with Pinteraction = 0.43. Conclusions: In patients with recent acute coronary syndromes and LDL-C near 70 mg/dL on optimized statin therapy, proprotein subtilisin/kexin type 9 inhibition provides incremental clinical benefit only when lipoprotein(a) concentration is at least mildly elevated. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2021
• Auteurs : Mark McclanahanMichael DempseyHelen ColhounIsabelle ZobouyanPatrick PicaultAurelie PerthuisChristine MorrelloDominique Fournie-LloretZhu ChengyueRaluca CotrutaMarion VincendetMarc SottyMaxime MourguesLamia MetwallyBenjamin HalleHelene Dubois-GachePauline BarraudPascale BeltranAntony AdamoChristelle RondelAnne OurliacMickael NormandVirginie LoizeauValerie GouetAlexis EtienneChristelle LorenzatoJérôme RepincayChristelle BerthouAnthony CoulangeRaphael BejuitMichel ScemamaKatarina KralovaMaud LamoureuxNafissa BengraitFadela BenbernouValerie PellanSebastien SopenaJennifer ShellerLucile SmithBetim OkanBicky MthombeniAsmaa MrabtiUlises MoralesMyriam MonierJulien LabeirieCarine JavierreGayatri JaiwalMegan HeathJan HealySeverine GuillouCaroline GobillotCecile GacheSzilvia DomokosDawn DevaulJoseph CianciaruloMaddy BrocklehurstImane BriguiCecile BouancheauMhamed BekkoucheEmmy BadreddineDorthe AndersenVeronique AgnettiMelanie VerrierJudith MurphySylvie FontecaveDouglas FaustinoNathalie BougonMarie-France BrégeaultShahidul IslamLena GrunbergMichelle ShawLiddy GriffithJulie ButtersAnne LuytenCaroline AlsweilerTabassome SimonElodie DrouetMadeleine BezaultCarla RovitoAndrea PascualMelissa WestbrookTyrus RorickKirby QuinteroAnita HepditchLisa BerdanJanine ValirisCaroline RatkyAlexander MatthewsJulianna WozniakJanaina OliveiraAnelise KawakamiFlavia EgydioEric BallDavid LaxsonJohn HunterJohn KostisKishor VoraRamprasad DandillayaGeraldine GardnerBill HarrisDouglas JacobyJay AndersonRichard GilmoreRobert FosterJames WelkerTerry WellsJoanne CoblerJustine KrawczykLaura AkrightDawood GamilHoward RubensteinGregory GieslerMichael LovePurushotham KothaGary ConradNizar AssiTammam Al JoundiAref RahmanPaul GibsonAlexander MacdonellDouglas DenhamImran DotaniStuart ChristensonJohn SchmedtjeCharles EatonGopal ChalavaryaJohn GilbertBranislav SchifferdeckerJohn HenrySherrill MurphyMark ChangWilliam PennyJessica BirchemHimanshu AgarwalSandeep KhuranaDonald WesterhausenWilliam KeenHenry LuiSuhail DohadRonald KarlsbergCarlos BayronMark ZaineaDiwakar JainP. Sandy SundramMichael SchwartzSamir TurkMartin McgoughJoel LandzbergSteven EisenbergDwight StapletonDaniel SpornMichael RadinEric YangRobert BarruccoRobert FishbergMichael BerlowitzHinan AhmedRiyaz BashirMukesh SharmaRakesh VohraPaul NagerTheodore PopeAhed NahhasF. Martin LesterKapildeo LotunNampalli VijayJason HallMajed ChaneAnthony VoSuneet MittalJanet StrainDouglas SpriggsSeals AlbertEdward PereiraSteven SchwartzMark NeustelLawrence GimpleDouglas GuySteve DiamantisWilliam FrenchStewart PollockMichael FarrarNorman ErenrichMichael RaySamir PancholyDonald EagertonEugene SorokaStuart FischerDavid HoffmanStephen WelkaJoshua PurowSteven LupovitchGreg KumkumianAjit KhairaAmit KheraParag JoshiPeter RossiMartin BerkRohr KathrynRobert WeissEdmund ClaxtonH. John MaraisKwan LeeAjay LabrooAyim Akyea-DjamsonRonald BlonderJames StraderRavi BhagwatNeal PerlmutterMark XenakisDaniel FisherSridhar BanuruNaseem JaffraniDinesh SingalPhilip O’donnellKeattiyoat WattanakitClara MasseyGeert JongChristopher MalozziAndreas WaliMohamadali AmlaniAndrey EspinozaGlen TonnessenMalcolm FosterKevin SilverJeffrey KuvinCarey KimmelstielPhillip RozemanArthur LoussararianFred ChaleffDennis FriedmanThomas KnutsonMladen VidovichHyeun (tom) ParkLiwa YounisJaime GerberCharles CareyMarilyn KingGeorge VetrovecAntonio AbbateAjit RaisinghaniCharles LambertJames FairlambGregory RoseJoseph RossiZachary HodesEbrahimi RaminFreny ModyAlan ChuThomas GalskiDaniels ChristopherWade MayAlvaro AlonsoAnand IrimpenHoward WeintraubMahfouz El ShahawyNorman LeporParilak LeonardEichenlaub TimothyRosemary NowinsJason LindseyKeith FriedmanWilliam HerzogRobert PedersonMark PiconeCarsten SchmalfussMasoud AzizadWilliam SheldonThomas BlokStephen VoyceVipul PanchalJoseph McgarveyZubair JafarGeorge PonceFiras ZahrPhillip HorwitzNizar DaboulRolf AndersenShawn SpeirsJack WhitakerSharan MahalGeoffrey KlineNaim FarhatTimothy SchuchardDavid HendersonChristian GringBabak VakiliNandkishore RanadiveSumeet SubherwalOthman IslamMatthew WhiteJalal AbbasStephen ThewWenwu ZhangBrent MclaurinPeter KuhlmanEdward TeufelJohn LarryArnold GhitisGeorge KinzfoglAnna BortnickChad LinkRose DoBrack HattlerAnil KumarMark IzzoRahul AggarwalVipul ShahMazen Abu-FadelTheodore TakataWinfried WaiderHoward LeviteSanjay ShettyNicholas KondoFriederike KeatingKerensky RichardChristopher DanielsJoseph GelorminiBrett BermanCarl PepineDenise JanosikAnil ShahNarendra SinghSarah FentonJames RiderWayne LeimbachAmarnath VedereMaitreya ThakkarJohn PasquiniShahram YazdaniWilliam DavisJohn KobayashiAndrew SumnerJoseph MoranMatthew JanikJames BengstonTauqir GorayaGeorge DoddsHarish ChandnaMichael KorenSai DevarapalliVinay MalhotraKim KlanckeIon JovinAngel MulkaySunder RaoAmir MalikTariq HaddadKenneth SabatinoDaniel DotyLuther CarterSteven CohenBarry HarrisKatie MoriartyWilliam NelsonFadi El-AhdabMichael d'UrsoEric CarlsonFaiq AkhterMouhamad AbdallahImran ArifDavid SuhThomas AmidonEve GillespieThomas HaldisThomas KnickelbineLindsey WhiteMian HasanPerry KrichmarCara EastPriya KumarIra LieberPatrick CambierGeorges DagherMohammad ShoukfehMisal KhanJonathan WaltmanLes ForgoshEdward KosinskiWilliam RogersMichael RosenbergShi-Chi ChengScott WrightEnrique FloresCarlos InceAnn Elizabeth MohartSanjeev PuriAbul KhanAlan WisemanBruce PalmerCharles DahlCharles Treasure IiDavid BrabhamDuccio BaldariGil VardiNicholas Ossei-GerningSean GallagherJulian HalcoxDavid FitzmauricePeter WilkinsonRob ButlerDavid SprigingsDavid SharmanTimothy ReynoldsAyyaz SultanGohar RahmanTelal MudawiSimon ThackrayRichard OliverMuhammad CheemaMohammad AyazAdrian BrodisonAnthony MathurHandrean SoranAudrius SimaitisRobert GerberHoner KadrCraig BarrTerry LevyJohn KurianSimon SmithRangasamy MuthusamySam McclureHuw GriffithsRobert StoreyDavid SarkarDenise BraganzaEduardas SubkovasSyed M.R. IqbalYuk-Ki WongPiers CliffordRajesh AggarwalAndrew MoriartyKaeng LeeAzfar ZamanJasper TrevelyanVolodymyr ZheleznyyAnatolii RudenkoBorys GoloborodkoGeorgiy DzyakOlexiy UshakovOlga BarnaAndriy BagriyMykola VatutinAndriy YagenskyMykola KopytsyaMykola RishkoOleh LeshchukViktor TashchukEkaterina AmosovaOles KutniyAndriy KlantsaYaroslav MalynovskyYuriy KarpenkoYulian KyiakMykola StanislavchukYuriy MostovoyVira TseluykoMykola KushnirIhor KovalskyiLeonid RudenkoValeriy BatushkinDmytro ReshotkoHalyna MyshanychIhor VakaluykAlexander ProkhorovOleksandr KarpenkoLale KoldasErtan UralCevat KirmaMustafa DemirtasMurat ErsanliBulent MutluHakan KultursayAhmet CamsariPaiboon ChotnoparatpatDilok PiyayotaiWirash KehasukcharoenNakarin SansanayudhKrisada SastravahaNattawut WongpraparutApichard SukonthasarnWoravut JintapakornWasant SoonfuangPinij KaewsuwannaChih-Yuan FangTsuei-Yuan HuangJen-Yuan KuoWei Hsiang LinMing-Jer HsiehI-Chang HsiehWei-Hsian YinJuey-Jen HwangMing-En LiuWen-Ter LaiKwo-Chang UengWei-Chuan TsaiOliver GämperliRonald BindeFrancois MachChristian MüllerTiziano MoccettiTorbjörn SundelinUlf AhremarkIngemar TorstenssonSteen Agergaard JensenStefano RomeoOle HansenPeter NicolGeorgios MourtzinisNils WittOla VedinGundars RasmanisStefan BerglundNaomali AmarasenaJagath HerathAjantha RajapakshaThilak SirisenaGnanamoorthy MayurathanVajira SenaratneSepalika MendisRuvan EkanayakaGotabhaya RanasingheSantharaj WijeyasingamJayanthimala JayawardenaKaputella FernandoNimali FernandoChandrike PonnamperumaStanley AmarasekeraNirmali TisseraRuvaiz HaniffaGodwin ConstantinePedro ValdivielsoNorberto Alonso OrcajoAntonio Coca PayerasJuan EscudierJavier Balaguer RecenaPablo Loma-Osorio RinconCésar Morís de La TassaIgnacio Plaza PerezMercedes Camprubí PotauCarlos Gonzalez-JuanateyAmparo BenedictoGabriel Gusi TragantJavier Botas RodriguezJuan Cosín SalesJosé Alberto García LledóJose Francisco Díaz FernándezJosé Antonio Vázquez de PradaJosé de Berrazueta FernándezJose Maria Serrano AntolinJoaquin Alonso MartinJordi Bruguera CortadaManuel de Mora MartinJose Luis ZamoranoLaia Matas PericasFernando Civeira MurilloJavier Fernandez PortalesJose Gonzalez-JuanateyJosé Tuñón FernándezAndres IñiguezDavid Garcia-DoradoFernando Worner DizPablo ToledoBlas Gil-ExtremeraRafael Jesus Hidalgo UrbanoJose Cruz FernándezFrancisco MarínFrancisco Fuentes JimenezVicente Bodí PerisAngel Cequier FillatManuel VidaRajendran MoodleyHelmuth ReuterJoseph MynhardtMahomed SarvanIftikhar EbrahimGarda RiazSoraya CassimjeePatrick CommerfordJan SaaimanThayabran PillayPeter SebastianLouis van ZylDina van AswegenHanlie LotteringMatthys de V. BassonIlse KappHendrik Du Toit TheronEllen Makoali MakotokoJunaid BayatClive CorbettNaresh RanjithHenry CysterMatija CevcNataša Černič ŠuligojJanez PoklukarIvan ŽuranPeter OlexaAndrej DukatRudolf SmikJaroslava StrbovaGabriel KamenskyJuraj SeleckyViliam BuganJozef GonsorcikFrantišek FazekasAndrej DzupinaIvan MajercákJuraj MazurJuraj PalkaMarian HranaiPeter FulopDaniel PellaJan NociarKarol MickoJustin Tang I-ShingHean Yee OngKian-Keong PohTamara JakimovSinisa DimkovicSlobodan DodicAna KaradzicPetar SeferovicDragan DincicJovan BalinovacBranislava TodicSlavica RadovanovicAleksandra ArandjelovicAleksandar StankovicBiljana Putnikovic TosicStevan IlicSvetlana ApostolovicStevo StojicMilika AsaninNebojsa TasicGoran DavidovicNikola IvanovicDragan SimicSergey KanorskyMasterov IlyaIgor IvanovVadim TyrenkoLiudmila EgorovaAnton PovzunYuriy KarpovElena KosmachovaZaur ShogenovElena BaranovaLiudmila GaponKonstantin NikolaevOlga MolchanovaTatiana SotnikovaOlga ReshetkoNiiaz KhasanovIvan GordeevSergey YakushinSergey ShustovEvgeny BaranovTatyana TretyakovaMikhail VoevodaIgor LibovGalina ChumakovaEvgenia AkatovaVladimir ShchekotovNatalya OsokinaInna ViktorovaPetr ChizhovLarisa KhaishevaSergey ShalaevTatiana KhlevchukIgor BokarevNikita LomakinRaisa StryukVictor GurevichAlexander VishnevskyKonstantin ZrazhevskyAlexander GordienkoNadezhda LyaminaValentin MarkovOlga BarbarashZhanna KobalavaOlga OrlikovaYury ShvartsDoina DimulescuRodica Stanescu-CioranuIoan ComanMihaela MalisTom AlexandruAdrian MateiIrinel ParepaDoina RosuConstantin MilitaruCristina BengusMircea C.A. ConstantinescuCristian G.C. PodoleanuSilviu DumitrescuGabriel CristianDan TesloianuOctavian IstratoaieBogdan MinescuFrancisca CaetanoAna BotelhoCarlos MendonçaFilipe SeixoDinis MartinsHelder PereiraJose Mesquita BastosPedro MonteiroHanna SzwedGrzegorz RaczakEdward FranekJerzy GornyAndrzej LubinskiJacek GniotEwa Mirek-BryniarskaTomasz CzerskiMarek KorolMichal SzpajerLeszek BystrykTomasz BlicharskiArkadiusz StasiewskiRyszard SciborskiAnna DrzewieckaMarek PiepiorkaEdyta Kostarska-SrokoszJan Andrzej LipkoJacek KubicaBeata MiklaszewiczMarcin SkorskiAleksander ZurakowskiWanda SudnikWlodzimierz KrasowskiKrzysztof SaminskiElzbieta DulakPawel StanetaAleksander GochJanusz BednarskiBenita Busz-PapiezPawel WojewodaLidia PawlowiczGrzegorz SkoniecznyKrystyna JaworskaAdrian WlodarczakDennis Jose SulitEdgar TanDante MoralesGregorio RogelioAlisa BernanRaul Martin CochingGeneroso MatigaRody SyLouie TiradorRosa Allyn G. 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HerrmanWalter R.M. HermansJan CornelGerard BartelsNadea Y.Y. Al-WindyEric ViergeverRoland P.T. TroquayBart R.G. BruerenGerardus J.E. VerdelJohan JukemaIoannis KaralisHenricus van KesterenPascalle MonraatsPeter ZwartRuud M.A. van Der WalDirk BasartJacobijne WiersmaPaulus van HaelstAntonius OomenHarry SuryapranataPieter A.M. 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ReisWeimar K.S.B. SouzaFernando CostaJuliana de SouzaLuiz Eduardo F. RittGilson FeitosaJose Marin-NetoWladmir SaporitoJose SilveiraPedro SilvaJose Moura JorgeDalton PrecomaEuler Roberto Fernandes ManentiSergio KaiserRoberto BotelhoPaulo LeaesMaria VidottiFreddy EliaschewitzYorghos MichalarosLuiz BodaneseFernando NeuenschwanderMayler O.N. de SantosAna Priscila SoggiaPedro Pimentel FilhoJosé Antonio M. AbrantesAdrian KormannRenato KalilNorberto DudaMaria José A.G. CerqueiraPaulo R.F. RossiRafael RechLilia Nigro MaiaRicardo SilvaFlavio GiorgetoJose NicolauLuciano SousaGilmar ReisBoris GoronjaAdis MuslibegovicDusko VulicAzra Durak-NalbanticMehmed KulićEmir FazlibegovicBelma PojskicZlatko MidzicFahir BarakovicIbrahim TerzicFrank CoolsMarc ClaeysEmanuele BarbatoJohn RoosenCarl ConvensHarry StriekwoldGeert VervoortChristophe BeauloyeKarl DujardinMarc CastadotBart WollaertLuc de WolfMathias C.M. VrolixEtienne HofferAttilio LeoneBruno PirenneKurt HermansDirk FaesFranz WeidingerBernhard FreyGeorg Delle-KarthRudolf BergerKurt HuberUta HoppeRobert ZweikerRonald DickPatrick CarrollMark SaderGregory StarmerPaul GarrahySteven G.M. CoverdaleConstantine AroneySam LehmanOwen RaffelPhilip Roberts-ThomsonRomulo Oqueli FloresDavid ColquhounJames RogersDaniel NinioJohn HorowitzMargaret ArstallJames ShawChris L.S. HiiAllan SowardNicholas CollinsJonathon WaitesSusana LloisOsvaldo CostamagnaGerardo ZapataSilvia SaavedraJorge GiordanoHugo LuquezHoracio CestariRuben Garcia DuranMario BerliGabriel WaismanHector LuciardiVictorino FuentealbaAlberto LibermanHugo ColomboEduardo D.S. BlumbergSebastian NaniMiguel Bustamante LabartaDaniela Garcia BrascaJuan Medrano AllendePablo GuzmanGabriela CarneroMarisa VicoRicardo DranMaria GiulianoCesar ZaidmanCristian PatocchiFederico NovoaRodolfo Ahuad GuerreroJulio VallejosAdrian HrabarJulio O.E. BonoHoracio JureOscar CoduttiOscar SalomoneMarcos AmuchasteguiGuillermo CaimeIgnacio MackinnonGustavo PaterliniLuis CartasegnaAlberto LorenzattiOscar Gomez VilamajoAlberto CaccavoOscar MontañaMiguel Angel HominalLeonardo NovarettoOrlando CarusoErnesto DurontoJorge SchmidbergAlberto Alves de LimaAnselmo BordonavaSonia SassoneAndrés AlvarisquetaMarcelo GarridoLilia SchiaviAndrew YanMatthew WilsonSean van DiepenCharlene TrotterMustafa TomaDarin SujjavanichKenya StringfellowMatthew SherwoodBimal ShahWilliam Schuyler JonesEtienne PuymiratThomas PovsicLynn PerkinsSabrina Bernardez-PereiraChetan PatelHumberto Graner MoreiraRobert MentzRajendra MehtaRobin MathewsJill MarcusDavid MaronLinda LillisSergio LeonardiDavid KongBradley KollsJoshua KnowlesJoseph Dedrick JordanMark HlatkyConnie Ng HessRobert HarrisonArleen EppingerPatricia EndsleyZubin EapenGrégory DucrocqKeith DombrowskiSheila DickeyShalonda DeloatchAdam DevoreShaun CliftonJ. Matthew BrennanMaria Cecilia BahitAkshay BagaiLuciana ArmaganijanJohn AlexanderEric J.G. SijbrandsRobert RosensonChiara MeloniKaren AlexanderMaarten SimoonsJean-Lucien RouleauAnders OlssonSheryl KelseyBernard ChaitmanRobert VogelPatrick MoriartyKausik RayAlexander ParkhomenkoSema GuneriPiyamitr SritaraChern-En ChiangUlf LandmesserEmil HagströmH. Asita de SilvaJosé TuñónAnthony DalbyZlatko FrasJan MurinTerrance ChuaArsen RisticYuri KarpovMaria DorobantuJoao MoraisAndrzej BudajRoger Correa FloresSigrun HalvorsenMarco AlingsGabriel Arturo Ramos LópezKhalid YusoffSasko KedevAleksandras LauceviciusAndrejs ErglisSang-Hyun KimHyo Soo KimTakeshi KimuraMarco ValgimigliDoron ZahgerDenis XavierRobert Gabor KissHung-Fat TsePablo Carlos Montenegro ValdovinosEvangelos LiberopoulosNicolas DanchinNikolaus MarxVakhtang ChumburidzeMarkku NieminenMargus ViigimaaPetr OstadalZeljko ReinerIvan PećinPatricio López-JaramilloHuo YongJuan-Carlos PrietoNina GotchevaRenato LopesMirza DilicPeter SinnaeveHeinz DrexelPhilip AylwardJean-François TambyWilliam SasielaAngèle MoryusefGuillaume LecorpsCorinne HanotinJay EdelbergKenneth MahaffeyMatthew RoePierluigi TricociAndreas ZeiherRobert HarringtonJ. Wouter JukemaPhilippe Gabriel StegHarvey WhiteRobert PordyGaren ManvelianMegan LoyJ Wouter JukemaShaun GoodmanRafael DiazDeepak L BhattVera BittnerMichael SzarekGregory Schwartz
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Auckland City Hospital Regeneron Pharmaceuticals [Tarrytown] Regeneron Pharmaceuticals [Tarrytown] Sanofi Bridgewater Leiden University Medical Center (LUMC) University of Alberta St. Michael's Hospital ECLAEstudios Clínicos Latino América & Instituto Cardiovascular de Rosario), Rosario, Argentina Brigham & Women’s Hospital [Boston] University of Alabama at Birmingham [ Birmingham] University of Colorado Anschutz [Aurora] Clinical Research Center State University of New York University of Colorado Anschutz [Aurora]
• Publié dans Diabetes Care le 01/11/2020

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Résumé : OBJECTIVE In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary syndrome. Incident diabetes was determined from laboratory, medication, and adverse event data. RESULTS Among 13,480 patients without diabetes at baseline, 1,324 developed type 2 diabetes over a median 2.7 years. Median baseline lipoprotein(a) was 21.9 mg/dL. With placebo, 10 mg/dL lower baseline lipoprotein(a) was associated with hazard ratio 1.04 (95% CI 1.02−1.06, P < 0.001) for incident type 2 diabetes. Alirocumab reduced lipoprotein(a) by a median 23.2% with greater absolute reductions from higher baseline levels and no overall effect on incident type 2 diabetes (hazard ratio 0.95, 95% CI 0.85–1.05). At low baseline lipoprotein(a) levels, alirocumab tended to reduce incident type 2 diabetes, while at high baseline lipoprotein(a) alirocumab tended to increase incident type 2 diabetes compared with placebo (treatment–baseline lipoprotein(a) interaction P = 0.006). In the alirocumab group, a 10 mg/dL decrease in lipoprotein(a) from baseline was associated with hazard ratio 1.07 (95% CI 1.03−1.12; P = 0.0002) for incident type 2 diabetes. CONCLUSIONS In patients with acute coronary syndrome, baseline lipoprotein(a) concentration associated inversely with incident type 2 diabetes. Alirocumab had neutral overall effect on incident type 2 diabetes. However, treatment-related reductions in lipoprotein(a), more pronounced from high baseline levels, were associated with increased risk of incident type 2 diabetes. Whether these findings pertain to other therapies that reduce lipoprotein(a) is undetermined.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2019
• Auteurs : Hamed EkhtiariHosna TavakoliGiovanni AddoloratoChris BaekenAntonello BonciSalvatore CampanellaLuis Castelo-BrancoGaëlle Challet-BoujuVincent ClarkEric ClausPinhas DannonAlessandra del FeliceTess den UylMarco DianaMassimo Di GiannantonioJohn FedotaPaul FitzgeraldLuigi GallimbertiM. BronnecSarah HerremansMartin HerrmannAsif JamilEman KhedrChristos KouimtsidisKarolina KozakEvgeny KrupitskyClaus LammWilliam LechnerGraziella MadeoNastaran MalmirGiovanni MartinottiWilliam McdonaldChiara MontemitroEster Nakamura-PalaciosMohammad NasehiXavier NoëlMasoud NosratabadiMartin PaulusMauro PettorrusoBasant PradhanSamir PraharajHaley RaffertyGregory SahlemBetty Jo SalmeronAnne SauvagetRenée SchluterCarmen SergiouAlireza ShahbabaieChristine ShefferPrimavera SpagnoloVaughn SteeleTi-Fei YuanJosanne D.M. van DongenVincent van WaesGanesan VenkatasubramanianAntonio Verdejo-GarcíaIlse VerveerJustine WelshMichael WesleyKatie WitkiewitzFatemeh YavariMohammad-Reza ZarrindastLaurie ZawertailoXiaochu ZhangYoon-Hee ChaTony GeorgeFlavio FrohlichAnna GoudriaanShirley FecteauStacey DaughtersElliot SteinFelipe FregniMichael NitscheAbraham ZangenMarom BiksonColleen Hanlon
• Organismes : Laboratoires de neurosciences intégratives et cliniques (EA 481)
• Publié dans Neuroscience and Biobehavioral Reviews le 22/10/2020

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