Justine Paulus

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• Type de publi. : Thèse
• Date de publi. : 20/12/2023
• Auteurs : Justine Paulus
• Organismes : Centre de Recherche en Gestion des Organisations

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Résumé : Notre thèse vise à répondre à la problématique : quel est le rôle du contrôle de gestion dans les Offices Publics de l’Habitat (OPH) confrontés à la complexité institutionnelle ? En étudiant ces organisations sujettes au pluralisme institutionnel (Greenwood et al., 2011), nous cherchons à enrichir la littérature (Château Terrisse, 2012 ; Boitier et Rivière, 2016 ; Renaud, 2017 ; Amans et al., 2020…) sur le rôle actif des dispositifs de contrôle de gestion dans l’hybridation de logiques potentiellement incompatibles. L’ancrage théorique de la thèse se situe dans le courant des microfondations de la théorie néo-institutionnelle (Thornton et Ocasio, 1999 ; Thornton et al., 2012).Notre démarche méthodologique est structurée en deux temps. Nous réalisons d’abord une étude qualitative sur Gesthome, un OPH en pleine mutation confronté à quatre logiques institutionnelles (bureaucratique, politique, de marché et professionnelle). Cette étude qualitative mobilise plusieurs méthodes de recueil et d’analyse des données : 16 entretiens semi-directifs auprès des parties prenantes internes et externes de cette organisation, l’analyse de 26 documents et des archives de 713 pages ainsi qu’une observation participante durant 3 ans (3 carnets de notes de 120 pages chacun). Ce travail de terrain minutieux est réalisé dans le cadre d’une Convention Industrielle de Formation par la Recherche (CIFRE).Pour l’analyse de contenu, nous utilisons le logiciel d’analyse qualitative N’Vivo. Puis, en complément de l’étude qualitative, une étude quantitative est menée auprès de 32 OPH sur le territoire français afin de vérifier la transférabilité des résultats obtenus au sein de Gesthome.Nous montrons que les dispositifs de contrôle de gestion permettent la coexistence des logiques, favorisent l’hybridation duale, voire « triale » des logiques en servant de base à des compromis. Il ressort de notre étude au sein de Gesthome et de l’étude quantitative quatre compromis (Amans et al., 2020) conduisant au polymorphisme organisationnel (Renaud, 2017) : un compromis des logiques politique et de marché, un compromis des logiques politique et professionnelle, un compromis des logiques de marché et professionnelle et enfin un compromis entre les trois logiques. En outre, nos travaux apportent un éclairage sur le pilotage des OPHLM encore balbutiant dans l'état de l'art.

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Fichiers liés : 107104_PAULUS_2023_archivage.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El 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KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnes LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalSébastien VielCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessia FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie CobatPierre-Emmanuel Morange
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research
• Publié dans Genome Medicine le 24/10/2020

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Résumé : We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7 , with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10 −4 ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10 −4 ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10 −3 ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10 −8 ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 −5 ). Conclusions Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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Fichiers liés : s13073-023-01173-8.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2022
• Auteurs : Emil HagströmPhilippe Gabriel StegMichael SzarekDeepak BhattVera BittnerNicolas DanchinRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaEvangelos LiberopoulosNikolaus MarxJennifer McginnissGaren ManvelianRobert PordyMichel ScemamaHarvey WhiteAndreas ZeiherGregory SchwartzGregory SchwartzDeepak BhattVera BittnerRafael DiazShaun GoodmanRobert HarringtonJ. Wouter JukemaMichael SzarekHarvey WhiteAndreas ZeiherPierluigi TricociMatthew RoeKenneth MahaffeyJay EdelbergCorinne HanotinGuillaume LecorpsAngèle MoryusefRobert PordyWilliam SasielaJean-François TambyRafael DiazPhilip AylwardHeinz DrexelPeter SinnaeveMirza DilicRenato LopesNina GotchevaShaun GoodmanJuan-Carlos PrietoHuo YongPatricio López-JaramilloIvan PećinZeljko ReinerPetr OstadalSteen Hvitfeldt PoulsenMargus ViigimaaMarkku NieminenNicolas DanchinVakhtang ChumburidzeNikolaus MarxEvangelos LiberopoulosPablo CarlosMontenegro ValdovinosHung-Fat TseRobert Gabor KissDenis XavierDoron ZahgerMarco ValgimigliTakeshi KimuraHyo Soo KimSang-Hyun KimAndrejs ErglisAleksandras LauceviciusSasko KedevKhalid YusoffGabriel Arturo Ramos LópezMarco AlingsHarvey WhiteSigrun HalvorsenRoger Correa FloresRody SyAndrzej BudajJoao MoraisMaria DorobantuYuri KarpovArsen RisticTerrance ChuaJan MurinZlatko FrasAnthony DalbyJosé TuñónH. Asita de SilvaEmil HagströmUlf LandmesserChristian MüllerChern-En ChiangPiyamitr SritaraSema GuneriAlexander ParkhomenkoKausik RayPatrick MoriartyMatthew RoeRobert VogelBernard ChaitmanSheryl KelseyAnders OlssonJean-Lucien RouleauMaarten SimoonsKaren AlexanderChiara MeloniRobert RosensonEric J.G. SijbrandsPierluigi TricociJohn AlexanderLuciana ArmaganijanAkshay BagaiMaria Cecilia BahitJ. Matthew BrennanShaun CliftonAdam DevoreShalonda DeloatchSheila DickeyKeith DombrowskiGrégory DucrocqZubin EapenPatricia EndsleyArleen EppingerRobert HarrisonConnie Ng HessMark HlatkyJoseph Dedrick JordanJoshua KnowlesBradley KollsDavid KongSergio LeonardiLinda LillisRenato LopesDavid MaronKenneth MahaffeyJill MarcusRobin MathewsRajendra MehtaRobert MentzHumberto Graner MoreiraChetan PatelSabrina Bernardez PereiraLynn PerkinsThomas PovsicEtienne PuymiratMatthew RoeWilliam Schuyler JonesBimal ShahMatthew SherwoodKenya StringfellowDarin SujjavanichMustafa TomaCharlene TrotterSean F.P. van DiepenMatthew WilsonAndrew Tze-Kay YanLilia SchiaviMarcelo GarridoAndrés AlvarisquetaSonia SassoneAnselmo BordonavaAlberto Alves de LimaJorge SchmidbergErnesto DurontoOrlando CarusoLeonardo NovarettoMiguel Angel HominalOscar MontañaAlberto CaccavoOscar Gomez VilamajoAlberto LorenzattiLuis CartasegnaGustavo PaterliniIgnacio MackinnonGuillermo CaimeMarcos AmuchasteguiOscar SalomoneOscar CoduttiHoracio 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TzekovaHaralambi BenovStanislav PetranovHaralin TumbevNina Shehova-YankovaDimitar MarkovDimitar RaevMihail MollovKostadin KichukovKatya Ilieva- PandevaNina GotchevaRaya IvanovaMaryana GospodinovValentina MinchevaPetar LazovBojidar DimovManohara SenaratneJames StoneJan KornderStephen PearceDanielle DionDaniel SavardYves PesantAmritanshu PandeySimon RobinsonGilbert GosselinSaul VizelGordon HoagRonald BourgeoisAnne MorissetEric SabbahBruce SussexSimon KouzPaul MacdonaldAriel DiazNicolas MichaudDavid FellRaymond LeungTycho VuurmansChristopher LaiFrank NigroRichard DaviesGustavo NogaredaRam VijayaraghavanJohn DucasSerge LepageShamir MehtaJames ChaRobert DupuisPeter FongSohrab LutchmedialJosep Rodes-CabauHussein FadlallahDavid ClevelandThao HuynhIqbal BataAdnan HameedCristian PincettiSergio PotthoffJuan PrietoMonica AcevedoArnoldo AguirreMargarita VejarMario YañezGuillermo AranedaMauricio FernandezLuis PerezPaola VarletaFernando FlorenzanoLaura HuidobroCarlos RaffoClaudia OlivaresLeonardo NahuelpanHumberto MontecinosJiyan ChenYugang DongWeijian HuangJianzhong WangShi’an HuangZhuhua YaoXiang LiLan CuiWenhua LinYuemin SunJingfeng WangJianping LiXuelian ZhangHong ZhuDandan ChenLan HuangShaohong DongGuohai SuBiao XuXi SuXiaoshu ChengJinxiu LinWenxia ZongHuanming LiYi FengDingli XuXinchun YangYuannan KeXuefeng LinZheng ZhangZeqi ZhengZhurong LuoYundai ChenChunhua DingYi ZhongYang ZhengXiaodong LiDaoquan PengShuiping ZhaoYing LiXuebo LiuMeng WeiShaowen LiuYihua YuBaiming QuWeihong JiangYujie ZhouXingsheng ZhaoZuyi YuanYing GuoXiping XuXubo ShiJunbo GeGuosheng FuFeng BaiWeiyi FangXiling ShouXiangjun YangJian’an WangMeixiang XiangYingxian SunQinghua LuRuiyan ZhangJianhua ZhuYizhou XuZhongcai FanTianchang LiChun WuNicolas JaramilloGregorio Sanchez VallejoDiana Luna BotiaRodrigo Botero LopezDora de SalazarAlberto BonfantiCarlos Cotes ArocaJuan Diego HigueraMarco BlanquicettSandra Barrera SilvaHenry Garcia LozadaJulian Coronel ArroyoJose Accini MendozaRicardo Fernandez RuizAlvaro 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MärtsinTiina JurgensonArved KristjanMarkku NieminenSaila VikmanHeikki HuikuriJuhani AiraksinenPierre CosteEmile FerrariNicolas DanchinOlivier MorelGilles MontalescotJacques MachecourtGilles Barone-RochetteJacques MansouratiYves CottinPh. 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• Organismes : Laboratoire de Recherche Vasculaire Translationnelle
• Publié dans Circulation le 29/10/2020

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Résumé : Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome and elevated atherogenic lipoproteins despite optimized statin therapy. Primary outcome was major adverse cardiovascular events (MACE; coronary heart disease death, nonfatal myocardial infarction, fatal/nonfatal ischemic stroke, hospitalization for unstable angina). Associations between baseline apoB or apoB at 4 months and MACE were assessed in adjusted Cox proportional hazards and propensity score–matched models. Results: Median follow-up was 2.8 years. In proportional hazards analysis in the placebo group, MACE incidence increased across increasing baseline apoB strata (3.2 [95% CI, 2.9–3.6], 4.0 [95% CI, 3.6–4.5], and 5.5 [95% CI, 5.0–6.1] events per 100 patient-years in strata <75, 75–<90, ≥90 mg/dL, respectively; P trend <0.0001) and after adjustment for low-density lipoprotein cholesterol ( P trend =0.035). Higher baseline apoB stratum was associated with greater relative ( P trend <0.0001) and absolute reduction in MACE with alirocumab versus placebo. In the alirocumab group, the incidence of MACE after month 4 decreased monotonically across decreasing achieved apoB strata (4.26 [95% CI, 3.78–4.79], 3.09 [95% CI, 2.69–3.54], and 2.41 [95% CI, 2.11–2.76] events per 100 patient-years in strata ≥50, >35–<50, and ≤35 mg/dL, respectively). Compared with propensity score–matched patients from the placebo group, treatment hazard ratios for alirocumab also decreased monotonically across achieved apoB strata. Achieved apoB was predictive of MACE after adjustment for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol but not vice versa. Conclusions: In patients with recent acute coronary syndrome and elevated atherogenic lipoproteins, MACE increased across baseline apoB strata. Alirocumab reduced MACE across all strata of baseline apoB, with larger absolute reductions in patients with higher baseline levels. Lower achieved apoB was associated with lower risk of MACE, even after accounting for achieved low-density lipoprotein cholesterol or non–high-density lipoprotein cholesterol, indicating that apoB provides incremental information. Achievement of apoB levels as low as ≤35 mg/dL may reduce lipoprotein-attributable residual risk after acute coronary syndrome. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01663402.

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