Lydie CASSOU

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2023
• Auteurs : Benjamin GaboritBernard VanhoveKarine LacombeThomas GuimardLaurent HocquelouxLudivine PerrierVincent DubéeVirginie FerreCeline BressolletteRégis JosienAurélie Le ThuautMarie-Anne VibetAlexandra JobertEric DaillyFlorence AderSophie BrouardOdile DuvauxFrançois RaffiBenjamin GaboritFrançois RaffiMaeva LefebvreCharlotte BironRaphaël LecomteCécile BraudeauMarie ChauveauEric DaillyColin DeschanvresMatthieu GregoireAnne-Sophie LecomteLaurent FletMartine Tching-SinEugenie ClapeauJérémie OrainMorgane Le BrasAlexandre DuvalIsabelle PortierClara MoraAnne-Sophie BoureauEtienne Seronie-DoutriauxAgnès RouaudPamela HublainLaurence Le Jumeau de KergaradecCarole AgasseVivien DanieloMegguy BernardRégine ValeroKarine LacombeDiane BollensThibault ChiarabiniNadia ValinPatrick IngilizZineb OuazeneBénédicte LefebvreFrançois LecardonnelChristian TranRaynald FelihoManuela Le CamJulie LamarqueJean-Luc LagneauCyrielle LetaillandierAnne Daguenel-NguyenClémentine Mayala-KandaDjeneba FofanaArianna FiorentinoThomas GuimardYves BleherJean-Luc EsnaultDominique MerrienBlandine Le ClaireMarine MorrierDelphine BoucherRomain LamberetClémentine CoudonRomain DecoursHélène DurandArmelle PegeotEdwige MigneHélène PelerinYannick PoirierLaurent HocquelouxThierry PrazuckBarbara de DieuleveultPierre PloccoJérôme GuinardElisa DemonchyEric CuaEdouard DevaudStanislas HarentMarion PariseyCéleste LambertElise GobinJulien MansonPierre PasquierPascale MartresPatricia KessedjianHikombo HitotoNicolas CrochetteLucia Perez-GrandiereJean-Baptiste LaineArnaud Salmon-RousseauGuillaume CosseronSophie BlanchiFlorence AderValérie GalvanAlexia MoulinCorinne BrochierJulianne OddoneMaude Bouscambert-DuchampFirouzé Bani-SadrYohan N’guyenMaxime HentzienCédric CastexPhilippe BenoitVéronique BrodardDidier LaureillardAlbert SottoPaul LoubetAurélie MartinRégine DoncescoJulien MazetIan SoulairolRobin StephanFrançois GoehringerNathalie ThillyMichel PrevotHelene JeulinJean-Philippe TalarminLydie KhatchatourianNadia SaidanBrice GuerpillonPascaline RameauNicolas CassouThomas BriandF. LegallElodie Le BretonCédric JosephSandrine Soriot-ThomasClaire AndréjakJ.P. LanoixSophie BoddaertSandrine CastelainVincent PestreJuliette WoessnerSophie BayleStéphanie BrangerChristine ChristidesPhilippe BielefeldAdèle LacroixRoselyne Pillard-GaglianoIsabelle TrinhPierre LafitteGuillermo GiordanoMalena FinelloIgnacio LedesmaGustavo MartiniBenjamin DelafontaineIris CorusPierre BabyEmilie CatherinotCéline GoyardSimon ChauveauJad ChoucairBeatrice D’ursoMarie da Silva CostaLucie Le MeurMarc VasseTiffany PascreauEric FarfourBenjamin DervieuxC Charlotte KaeufferFrançois DanionYves HansmannNicolas LefebvreYvon RuchAxel UrsenbachCatherine Schmidt-MutterMuhtadi SulimanAnne HuttGuillaume BeckerElodie LaugelSophie BayerVincent DubéeRafael MahieuValérie DanielCaroline LefeuvreAlexandra DucancelleJean-Charles GagnardAbolfzl MohebbiMélanie DehaisSophie RaccahAnne-Lise PouliquenAlison KlasenEmmanuel ForestierMarie-Christine CarretSeverine LiardotJérôme GrosjeanJean-François FaucherJosselin BrissetAnne CypierreHélène DuroxPauline PinetSophie Ducroix-RoubertouClaire GenetChristine VallejoSébastien HantzMarie GousseffAntoine MerletSébastien BigotMarion Girard de CourtillesPascal PouedrasDelphine LariviereRenaud VerdonSylvie DargereJocelyn MichonAnna FournierSylvie BrucatoSéverine GautierCécile ValentinAnne RicciAntoine AlixFlore Lacassin-BellerRousseau SophieJérôme DimetAnne-Hélène BoivinMaylis LarregleGuillaume RousseauAdy AssafFanny VuottoKarine FaureCamille JoachimLaurence BocketKévin DialloJessy SafforeIsabelle MadelinePauline ChabanonNathalie AllouElisabeth FernandesAnne-Sophie GruliereElisabeth Botelho-NeversAmandine Gagneux-BrunonVéronique RonatNadine CasimirSylvie PilletFrédérique BertholonGilles PiallouxMarwa Bachir ElrufaaiRuxandra CalinPélagie ThibautFatima TendjaouiJulie FillonLaurence Morand-JoubertMarc-Olivier VareilHeidi WillePhilippe MenagerHugues CordelYoussouf Mohammed-KassimVanessa RathouinSégolène BrichlerAndré CabiéMélanie LehouxKarine GuitteaudKaramba SyllaBastien BigeardValentine CampanaIsabelle CalmontJean-Louis LamaignereMarine DeppenweillerChristophe PadoinMarine ThilbaultLaurence FagourFatiha NajioullahIsabelle Komla-SoukhaMariam Roncato-SaberanMartin MartinotMahsa Mohseni ZadehSimon GravierCiprian IonDamien KayserAnne Schieber PachartMagali EyrieyAnaïs HenricJean Daniel KaiserDominique de BrielOdile DuvauxGwenaëlle EvannoPierre-Joseph RoyerJuliette RousseCarine CironElsa LhériteauGaëtane RouvrayAlan MougeolleAuriane RilletSophie DesponsEdwige MevelFrançoise ShneikerRégis JosienCécile BraudeauSophie BrouardHoa Le MaiElise Appau-DanquahAmélie DanielVirginie GrybekDavid GueneauMarion GautierJoëlle Martin-GauthierEmily RebouilleauJoseph HeraultTanguy RomanSorady PlantardPatrice ChauveauAnne ChiffoleauStéphanie ThauvinLaurent FletMartine Tching-SinEugenie ClapeauIsabelle CharreauBruno HoenCaroline Solas-ChesneauAstrid Vabret
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique Centre d’Investigation Clinique de Nantes
• Publié dans Open Forum Infectious Diseases le 22/10/2020

---

Résumé : Abstract Background We evaluated the safety and efficacy of XAV-19, an antispike glyco-humanized swine polyclonal neutralizing antibody in patients hospitalized with severe coronavirus disease 2019 (COVID-19). Methods This phase 2b clinical trial enrolled adult patients from 34 hospitals in France. Eligible patients had a confirmed diagnosis of severe acute respiratory syndrome coronavirus 2 within 14 days of onset of symptoms that required hospitalization for low-flow oxygen therapy (<6 L/min of oxygen). Patients were randomly assigned to receive a single intravenous infusion of 2 mg/kg of XAV-19 or placebo. The primary end point was the occurrence of death or severe respiratory failure between baseline and day 15. Results Between January 12, 2021, and April 16, 2021, 398 patients were enrolled in the study and randomly assigned to XAV-19 or placebo. The modified intention-to-treat population comprised 388 participants who received full perfusion of XAV-19 (199 patients) or placebo (189 patients). The mean (SD) age was 59.8 (12.4) years, 249 (64.2%) individuals were men, and the median time (interquartile range) from symptom onset to enrollment was 9 (7–10) days. There was no statistically significant decrease in the cumulative incidence of death or severe respiratory failure through day 15 in the XAV-19 group vs the placebo group (53/199 [26.6%] vs 48/189 [25.4%]; adjusted risk difference, 0.6%; 95% CI, −6% to 7%; hazard ratio, 1.03; 95% CI, 0.64–1.66; P = .90). In the safety population, adverse events were reported in 75.4% of 199 patients in the XAV-19 group and in 76.3% of 190 patients in the placebo group through D29. Conclusions Among patients hospitalized with COVID-19 requiring low-flow oxygen therapy, treatment with a single intravenous dose of XAV-19, compared with placebo, did not show a significant difference in terms of disease progression at day 15.

---

Source