Pascal Fabre

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2023
• Auteurs : Fabien HalkettMéline SaubinXhaard ConstanceBecheler RonanStoeckel SolennFabre FrédéricCoville JérômeMarçais BenoîtPascal Frey
• Organismes : Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes

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• Type de publi. : Article dans une revue
• Date de publi. : 09/05/2023
• Auteurs : Clémentine LouetMéline SaubinAxelle AndrieuxAntoine PersoonsMathilde GorseJérémy PétrowskiBénédicte FabreStéphane de MitaSébastien DuplessisPascal FreyFabien Halkett
• Organismes : Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes BIOlogie et GEstion des Risques en agriculture Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Plant Health Institute of Montpellier Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes Interactions Arbres-Microorganismes
• Publié dans Molecular Ecology le 29/10/2020

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Résumé : The deployment of plant varieties carrying resistance genes (R) exerts strong selection pressure on pathogen populations. Rapidly evolving avirulence genes (Avr) allow pathogens to escape R-mediated plant immunity through a variety of mechanisms, leading to virulence. The poplar rust fungus Melampsora larici-populina is a damaging pathogen of poplars in Europe. It underwent a major adaptive event in 1994, with the breakdown of the poplar RMlp7 resistance gene. Population genomics studies identified a locus in the genome of M. larici-populina that probably corresponds to the candidate avirulence gene AvrMlp7. Here, to further characterize this effector, we used a population genetics approach on a comprehensive set of 281 individuals recovered throughout a 28-year period encompassing the resistance breakdown event. Using two dedicated molecular tools, genotyping at the candidate locus highlighted two different alterations of a predominant allele found mainly before the resistance breakdown: a nonsynonymous mutation and a complete deletion of this locus. This results in six diploid genotypes: three genotypes related to the avirulent phenotype and three related to the virulent phenotype. The temporal survey of the candidate locus revealed that both alterations were found in association during the resistance breakdown event. They pre-existed before the breakdown in a heterozygous state with the predominant allele cited above. Altogether, these results suggest that the association of both alterations at the candidate locus AvrMlp7 drove the poplar rust adaptation to RMlp7-mediated immunity. This study demonstrates for the first time a case of adaptation from standing genetic variation in rust fungi during a qualitative resistance breakdown.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2023
• Auteurs : Christiana KartsonakiJ Kenneth BaillieNoelia García BarrioJoaquín BaruchAbigail BeaneLucille BlumbergFernando BozzaTessa BroadleyAidan BurrellGail CarsonBarbara Wanjiru CitarellaAndrew DagensEmmanuelle DankwaChristl DonnellyJake DunningLoubna ElotmaniMartina EscherNataly FarshaitJean-Christophe GoffardBronner GonçalvesMatthew HallMadiha HashmiBenedict Sim Lim HengAntonia HoWaasila JassatMiguel Pedrera JiménezCedric LaouenanSamantha LissauerIgnacio Martin-LoechesFrance MentréLaura MersonBen MortonDaniel MunblitNikita NekliudovAlistair NicholBudha Charan Singh OinamDavid OngPrasan Kumar PandaMichele PetrovicMark PritchardNagarajan RamakrishnanGrazielle Viana RamosClaire RogerOana SandulescuMalcolm SemplePratima SharmaLouise SigfridEmily SomersAnca Streinu-CercelFabio TacconePavan Kumar VechamBharath Kumar Tirupakuzhi VijayaraghavanJia WeiEvert-Jan WilsXin Ci WongPeter W. HorbyAmanda RojekPiero OlliaroAli AbbasSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelLara AbsilSubhash AcharyaAndrew AckerElisabeth AdamDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamAngela AlbertiTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliAdam AliNaseem Ali ShahKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesRita AlvesJoão Melo AlvesMaria AmaralNur AmiraPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise 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RahutullahFernando RainieriGiri Shan RajahramPratheema RamachandranAhmad Afiq RamliBlandine RammaertAsim RanaRajavardhan RangappaRitika RanjanChristophe RappAasiyah RashanThalha RashanGhulam RasheedMenaldi RasminIndrek RätsepCornelius RauTharmini RaviAli RazaAndre RealStanislas RebaudetSarah RedlBrenda ReeveAttaur RehmanLiadain ReidLiadain ReidDag Henrik ReikvamRenato ReisJordi RelloJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaLuis Felipe ReyesTiago ReyesMaria Ines RibeiroAntonia RicchiutoDavid RichardsonDenise RichardsonLaurent RichierSiti Nurul Atikah Ahmad RidzuanJordi RieraAna RiosAsgar RishuPatrick RispalKarine RissoMaria Angelica Rivera NuñezNicholas RizerChiara RobbaAndré RobertoStephanie RobertsDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaBernhard RoesslerPierre-Marie RogerEmmanuel RoilidesJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerNurul Hidayah Mohammad RoslanAndrea RossaneseMatteo RossettiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaria RyanMaeve RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaSairah SadafMusharaf SadatValla SahraeiMaximilien Saint-GillesPranya SakiyalakNawal SalahuddinLeonardo SalazarJodat SaleemGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroIam Claire E SarmientoBenjamine SartonAnkana SatyaSree SatyapriyaRumaisah SatyawatiEgle SaviciuteParthena SavvidouYen Tsen SawJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderStephan SchrollMichael SchwameisGary SchwartzBrendan SciclunaJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzJaganathan SelvanayagamMageswari SelvarajooCaroline SemailleRasidah Bt SenianEric SennevilleClaudia SepulvedaFilipa SequeiraTânia SequeiraAry Serpa NetoPablo Serrano BalazoteEllen ShadowitzSyamin Asyraf ShahidanMohammad ShamsahAnuraj ShankarShaikh SharjeelCatherine ShawVictoria ShawAshraf SheharyarRohan ShettyRajesh Mohan ShettyHaixia ShiNisreen ShibanMohiuddin ShiekhNobuaki ShimeHiroaki ShimizuKeiki ShimizuSally ShrapnelPramesh Sundar ShresthaShubha Kalyan ShresthaHoi Ping ShumNassima Si MohammedNg Yong SiangJeanne SibiudeAtif SiddiquiPiret SillaotsCatarina SilvaRogério SilvaMaria Joao SilvaWai Ching SinDario SinattiPunam SinghBudha Charan SinghPompini Agustina SitompulKarisha SivamVegard SkogenSue SmithBenjamin SmoodCoilin SmythMichelle SmythMichelle SmythMorgane SnackenDominic SoTze Vee SohJoshua SolomonTom SolomonAgnès SommetRima SongTae SongJack Song ChiaMichael SonntagbauerAzlan Mat SoomAlberto SottoEdouard SoumMarta SousaAna Chora SousaMaria Sousa UvaVicente Souza-DantasAlexandra SperryElisabetta SpinuzzaB DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelDavid StuartAmi StuartDecy SubektiGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováSuwarti SuwartiAndrey SvistunovSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziLysa TaghersetShahdattul Mawarni TaibEwa TalarekSara TalebJelmer TalsmaRenaud TamisierMaria Lawrensia TampubolonKim Keat TanYan Chyi TanTaku TanakaHiroyuki TanakaHayato TaniguchiHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikRichard TedderTze Yuan TeeJoão TeixeiraSofia TejadaMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitAnand ThakurZhang Duan ThamSuvintheran ThangaveluVincent ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonEmma ThomsonDavid ThomsonSurain Raaj Thanga ThuraiRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitNoémie TissotJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiMargarida TorresAntoni TorresRosario Maria Torres Santos-OlmoHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtleAnders TveitaPawel TwardowskiMakoto UchiyamaP UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsPiero ValentiniLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeMachteld van der FeltzJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfLaura van GulikJarne van HattemCarolien van NettenFrank van Someren GreveIlonka van VeenHugo van WilligenNoémie VanelHenk VanoverscheldePooja VargheseMichael VarroneShoban Raj VasudayanCharline VauchyShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoGayatri VishwanathanBenoit VisseauxHannah VisserChiara VitielloHarald VonkemanFanny VuottoSuhaila Abdul WahabNoor Hidayu WahabNadirah Abdul WahidMarina WainsteinWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbKatharina WeilTan Pei WenSanne WesseliusT Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsCalvin WongYew Sing WongTeck Fung WongNatalie WrightGan Ee XianLim Saio XianKuan Pei XuanIoannis XynogalasSiti Rohani Binti Mohd YakopMasaki YamazakiYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : University of Oxford Infection, Anti-microbiens, Modélisation, Evolution University of Oxford University of Oxford CHU Pontchaillou [Rennes] ARN régulateurs bactériens et médecine
• Publié dans International Journal of Epidemiology le 30/10/2020

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Résumé : Background: We describe demographic features, treatments and clinical outcomes in the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) COVID-19 cohort, one of the world's largest international, standardized data sets concerning hospitalized patients. Methods: The data set analysed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. We investigated how symptoms on admission, co-morbidities, risk factors and treatments varied by age, sex and other characteristics. We used Cox regression models to investigate associations between demographics, symptoms, co-morbidities and other factors with risk of death, admission to an intensive care unit (ICU) and invasive mechanical ventilation (IMV). Results: Data were available for 689 572 patients with laboratory-confirmed (91.1%) or clinically diagnosed (8.9%) SARS-CoV-2 infection from 52 countries. Age [adjusted hazard ratio per 10 years 1.49 (95% CI 1.48, 1.49)] and male sex [1.23 (1.21, 1.24)] were associated with a higher risk of death. Rates of admission to an ICU and use of IMV increased with age up to age 60 years then dropped. Symptoms, co-morbidities and treatments varied by age and had varied associations with clinical outcomes. The case-fatality ratio varied by country partly due to differences in the clinical characteristics of recruited patients and was on average 21.5%. Conclusions: Age was the strongest determinant of risk of death, with a ∼30-fold difference between the oldest and youngest groups; each of the co-morbidities included was associated with up to an almost 2-fold increase in risk. Smoking and obesity were also associated with a higher risk of death. The size of our international database and the standardized data collection method make this study a comprehensive international description of COVID-19 clinical features. Our findings may inform strategies that involve prioritization of patients hospitalized with COVID-19 who have a higher risk of death.

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• Type de publi. : Autre publication
• Date de publi. : 21/03/2023
• Auteurs : Amandine BellecPascal MartinNeus VilàStéphane LenfantStephane CampidelliY. J. DappeDenis FrathLuisa Della Rocca MariaBruno FabreSaioa Cobo
• Organismes : Laboratoire Matériaux et Phénomènes Quantiques Interfaces, Traitements, Organisation et Dynamique des Systèmes Université de Lorraine Nanostructures, nanoComponents & Molecules - IEMN Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Laboratoire Innovation en Chimie des Surfaces et NanoSciences Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) Service de physique de l'état condensé Groupe Modélisation et Théorie Laboratoire de Chimie - UMR5182 Laboratoire Matériaux et Phénomènes Quantiques Institut des Sciences Chimiques de Rennes Laboratoire de chimie de coordination

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Résumé : Sommaire : – Détection électrique de la transition de spin de molécules Amandine Bellec – Electroluminescence de molécules chargées adsorbées sur une surface métallique Amandine Bellec – Approche moléculaire pour la fabrication de surfaces fonctionnalisées de Qubits moléculaires Pascal Martin – Electropolymérisation itérative contrôlée Neus Vila – Formation et dissociation induites par STM des liaisons au sein d’une molécule Stéphane Lenfant – Synthèse de nanographène sur surface semi-conductrice Stéphane Campidelli – Véritable isolant topologique moléculaire ou simple fil moléculaire conducteur ? Yannick Dappe – Transfert de l’effet d’interférence quantique moléculaire à différentes échelles de longueur Maria Luisa Della Rocca – Commutateurs moléculaires dynamiques avec conductance différentielle négative hystérétique Denis Frath – Transport de charge intermoléculaire dans des assemblages supramoléculaires Denis Frath – Un nouveau moteur moléculaire électrique Bruno Fabre – Synergie entre propriétés électroniques et magnétiques dans un complexe de manganèse Saioa Cobo

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Fichiers liés : Chronique NEMO #1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/03/2023
• Auteurs : Lise CuzinPhilippe FlandreClotilde AllavenaRomain PalichClaudine DuvivierAgathe BeckerHélène LarochePascal PuglieseAndré CabieC ChirouzeO BabreK BouillerF BozonA BrunelE ChevalierL Hustache-MathieuJ LagoutteQ LepillerS Marty-QuinternetP MuretB RosolenN TissotS JaffuelC JacometC AumeranO BaudA BrebionV CorbinE GoncalvezC HenquellH LaurichesseO LesensD MazzocolinA MirandN MrozekC TheisM VidalI LamauryF BissuelF BoulardE CurlierI FabreE HalleyC Herrmann-StorckC Le GuillouS MarkowiczM MarquetR OuissaM ReceveurJ ReltienP RogerB TressieresD MerrienO BollangierD BoucherT GuimardL LaineS LeautezM MorrierP PerréP PointJ FaucherA CypierreS Ducroix-RoubertouH DuroxC Genet-VillegerJ PascualP PinetS RogezJ WoillardL CotteF AderD AlfaiateAgathe BeckerA BoibieuxC BrochierF Brunel-DalmasO CannessonP ChiarelloC ChidiacA ConradS DegroodtT FerryM GodinotV IcardJ LivrozetD MakhloufiT PerpointM PerryC PouderouxS RouxM TrabaudC Triffault-FillitF ValourI RavauxA MénardS AherfiS AmraneA BelkhirP ColsonC DhiverM Martin-DegioanniL MeddebM MokhtariA MotteH Tissot-DupontC ToméiI Poizot-MartinS BrégigeonM DucassouS GalieA IvanovaI JaquetHélène LarocheV Obry-RoguetM OrticoniE RessiotA RitlengT Rojas-RojasO Zaegel-FaucherAndré CabieS AbelJ BavayB BigeardO CabrasLise CuzinR Dupin de MajoubertL FagourK GuitteaudM LehouxC MontagnacS Pierre-FrançoisK RomeJ TurmelJ ReynesN AtouiM BistoquetE DelaporteV Le MoingJ LejeuneA MakinsonN MeftahC Merle de BoeverB MontesA Montoya FerrerE TuaillonB LefèvreM AndréG BaronnetS BevilacquaL BoyerM BouillonA CharmillonM DelestanE FrentiuF GoehringerS HénardE JeanmaireC RabaudA Radjabaly-MandjeeF RaffiClotilde AllavenaE André-GarnierA Asquier-KhatiE BillaudC BironB BonnetS BouchezD BoutoilleC Brunet-CartierM CavellecC DeschanvresV FerréB GaboritA GrégoireM GrégoireT JovelinM LefebvreR LecomteR MahotP MorineauE ParedesV ReliquetE André-GarnierS SécherA SoriaPascal PuglieseS BréaudM BuscotM CarlesD ChirioE CuaP DellamonicaE DemonchyA de MonteJ DurantS FerrandoR GarraffoC MichelangeliA NaqviI PerbostC PradierB Prouvost-KellerK RissoI TouitouA ViotS Wehrlen-PuglieseL HocquelouxC GubavuV LegrosF PeiraT PrazuckV RzepeckiA SèveA CheretA Barrail-TranA CastroR ColarinoC GoujardS JaureguiberryY QuertainmontE TeicherV JolyC CharpentierD DescampsM DigumberA GervaisJ GhosnZ JuliaR LandmanS LarivenS Le GacF LouniG PeytavinC RiouxY YazdanpanahClaudine DuvivierK AmazzoughG BenabdelmoumenP BossiG CessotC CharlierP ConsignyE Gomes-PiresK JidarE LafontF LanternierO LortholaryC LouisinJ LourencoC MelenotteP ParizeA PouvaretC RouzaudA SerrisF TouamC KatlamaR AgherC BlancY DudoitN HamaniN QatibI QzaibriL LenclumeRomain PalichL SchneiderS SeangR TubianaM ValantinF Bani-SadrM BermejoJ BergerS DemotierM HentzienG JulienI KmiecD LambertH MartyY N’guyenJ RomaruC ArvieuxM BaldeyrouF BenezitJ ChapplainM DupontJ DuthéT JovelinA LebotF LemaitreA MaillardC MorlatS Patrat-DelonM Poisson-VannierC PronierM RevestJ SinteffF SoualaP TattevinA Gagneux-BrunonE Botelho-NeversA FrésardF LuchtV RonatD ReyC CheneauC Bernard-HenryE de MautortSamira Fafi-KremerP FischerP GantnerC MélounouM PartisaniP DelobelM AlvarezN BiezunskiA DebardC DelpierreC GarnierG GaubeL LelièvreM MarcelG Martin-BlondelM PiffautL PorteK SauneO RobineauE AïssiF AjanaI AlcarazE AlidjinouV BacletL BocketA BoucherV DerdourM GilbertT HuleuxB Lafon-DesmursA MeybeckM PradierM TetartP ThillM ValetteN VigetG Corvaisier
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). Patients and methods Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL < 50 copies/mL) they had a minimum of two additional VL measurements. Cox models adjusted for sex, age, acquisition group, hepatitis B or C coinfection, place of birth, year of ART initiation, CD4+ T cells and VL at ART initiation, duration of known HIV infection and of ART regimen were used to assess the association between the time to VF and the occurrence of LLVL. ART regimen was evaluated as time-varying covariate. Results LLVL was described in 13.7% and VF in 11% of the 3302 patients. LLVL was associated with VF [adjusted HR (aHR) 1.76, 95% CI 1.28–2.41], as well as age (aHR 0.97/year, 95% CI 0.96–0.98), CD4+ T cell count at ART initiation (aHR 0.93, 95% CI 0.87–0.98), heterosexual transmission (aHR 1.76, 95% CI 1.30–2.37) and being born abroad (aHR 1.50, 95% CI 1.17–1.93). Conclusions LLVL was related to VF. Even in the absence of subsequent failure, LLV episodes have a cost. Thus any VL value above 50 copies/mL should lead to enhanced adherence counselling.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Amedeo AnselmiAlexandre MansourMarylou ParaNicolas MongardonAlizée PortoJulien GuihaireMarie-Catherine MorgantMatteo PozziBernard CholleyPierre-Emmanuel FalcozPhilippe GaudardGuillaume LebretonFrançois LabasteClaudio BarbantiOlivier FouquetSidney ChocronNicolas MottardMaxime EsvanClaire Fougerou-LeurentErwan FlecherAndré VincentelliNicolas NesselerMarc PierrotGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerClaire AlessandriRaphel BellaïcheOphélie ConstantQuentin RouxAndré LyArnaud MeffertJean-Claude MerleLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas d'OstrevyMarie-Catherine MorganPierre-Grégoire GuinotMaxime NguyenLucie Gaide-ChevronnayNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreAntoine GiraultIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaAgnes MugnierNatacha RousseSabrina ManganielloOlivier DesebbeJean-Luc FellahiRoland HenaineMatteo PozziJean-Christophe RichardZakaria RiadChristophe GuervillySami HraiechLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroKais BriniNicolas BischoffBruno LevyAntoine KimmounMathieu MatteiPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéBertrand RozecMickaël Vourc’hStéphane AubertFlorian BazalgetteClaire RogerPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchereMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiYannis GuyonvarchSophie HamadaAstrid BertierAnatole HarroisJordi MatielloThomas KerforneCorentin LacroixNicolas BrechotAlain CombesMatthieu SchmidtJuliette ChommelouxJean Michel ConstantinCosimo D’alessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HekimianCharles JuvinPascal LeprinceDavid LevyCharles Edouard LuytMarc Pineton de ChambrunThibaut SchoellPierre FillâtreNicolas MassartRoxane NicolasMaud JonasCharles VidalNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizinePhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierAnne OllandMarion VillardFanny BounesVincent MinvilleAntoine GuillonYannick FedunJames Ross
• Organismes : Laboratoire Traitement du Signal et de l'Image CHU Pontchaillou [Rennes] CHU Pontchaillou [Rennes] Centre d'Investigation Clinique [Rennes] Laboratoire de Recherche Vasculaire Translationnelle Institut Mondor de Recherche Biomédicale IMRB - PROTECT/"Pharmacologie et Technologies pour les Maladies Cardiovasculaires" [Créteil] Pôle des Cardiopathies Congénitales du Nouveau-Né à L'adulte - Centre Constitutif Cardiopathies Congénitales Complexes M3C, Groupe Hospitalier Paris Saint-Joseph, Hôpital Marie-Lannelongue, Inserm U999, Université Paris-Saclay Research on Healthcare Performance Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Franco-czech Laboratory for clinical research on obesity MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre d'Investigation Clinique [Rennes] CHU Pontchaillou [Rennes] Centre d'Investigation Clinique [Rennes] CHU Pontchaillou [Rennes] CHU Pontchaillou [Rennes] Laboratoire Traitement du Signal et de l'Image CHU Pontchaillou [Rennes] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer
• Publié dans European Journal of Cardio-Thoracic Surgery le 22/10/2020

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Résumé : Objectives: The clinical profile and outcomes of patients with Covid-19 who require veno-arterial or veno-venous-arterial extracorporeal membrane oxygenation (VA-ECMO - VAV-ECMO) are poorly understood. We aimed to describe the characteristics and outcomes of these patients and to identify predictors of both favorable and unfavorable outcomes.Methods: ECMOSARS is a multicenter, prospective, nationwide French registry enrolling patients who require VV/VA-ECMO in the context of Covid-19 infection (652 patients at 41 centers). We focused on 47 patients supported with VA- or VAV-ECMO for refractory cardiogenic shock.Results: Median age was 49. 14% of patients had a prior diagnosis of heart failure. The most common etiologies of cardiogenic shock were acute pulmonary embolism (30%), myocarditis (28%), and acute coronary syndrome (4%). E-CPR (Extracorporeal Cardiopulmonary Resuscitation) occurred in 38%. In-hospital survival was 28% in the whole cohort, and 43% when E-CPR patients were excluded. ECMO cannulation was associated with significant improvements in pH and FiO2 on day one, but non-survivors showed significantly more severe acidosis and higher FiO2 than survivors at this point (p = 0.030 and p = 0.006). Other factors associated with death were greater age (p = 0.02), higher BMI (p = 0.03), E-CPR (p = 0.001), non-myocarditis etiology (p = 0.02), higher serum lactates (p = 0.004), epinephrine (but not noradrenaline) use before initiation of ECMO (p = 0.003), hemorrhagic complications (p = 0.001), greater transfusion requirements (p = 0.001), and more severe SAVE and SAFE scores (p = 0.01 and p = 0.03).Conclusions: We report the largest focused analysis of VA- and VAV-ECMO recipients in Covid-19. Although relatively rare, the need for temporary mechanical circulatory support in these patients is associated with poor prognosis. However, VA-ECMO remains a viable solution to rescue carefully selected patients. We identified factors associated with poor prognosis and suggest that E-CPR is not a reasonable indication for VA-ECMO in this population.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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• Type de publi. : Rapport
• Date de publi. : 16/12/2022
• Auteurs : Florence GuillotAdeline BéaPascal Robert-Cols
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés CAUE 81 ACCA

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Fichiers liés : Cordes(81)-Ormeaux 2022 prefigur 2023.pdf

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