Pascal Fabre

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• Type de publi. : Article dans une revue
• Date de publi. : 06/03/2023
• Auteurs : Lise CuzinPhilippe FlandreClotilde AllavenaRomain PalichClaudine DuvivierAgathe BeckerHélène LarochePascal PuglieseAndré CabieC ChirouzeO BabreK BouillerF BozonA BrunelE ChevalierL Hustache-MathieuJ LagoutteQ LepillerS Marty-QuinternetP MuretB RosolenN TissotS JaffuelC JacometC AumeranO BaudA BrebionV CorbinE GoncalvezC HenquellH LaurichesseO LesensD MazzocolinA MirandN MrozekC TheisM VidalI LamauryF BissuelF BoulardE CurlierI FabreE HalleyC Herrmann-StorckC Le GuillouS MarkowiczM MarquetR OuissaM ReceveurJ ReltienP RogerB TressieresD MerrienO BollangierD BoucherT GuimardL LaineS LeautezM MorrierP PerréP PointJ FaucherA CypierreS Ducroix-RoubertouH DuroxC Genet-VillegerJ PascualP PinetS RogezJ WoillardL CotteF AderD AlfaiateAgathe BeckerA BoibieuxC BrochierF Brunel-DalmasO CannessonP ChiarelloC ChidiacA ConradS DegroodtT FerryM GodinotV IcardJ LivrozetD MakhloufiT PerpointM PerryC PouderouxS RouxM TrabaudC Triffault-FillitF ValourI RavauxA MénardS AherfiS AmraneA BelkhirP ColsonC DhiverM Martin-DegioanniL MeddebM MokhtariA MotteH Tissot-DupontC ToméiI Poizot-MartinS BrégigeonM DucassouS GalieA IvanovaI JaquetHélène LarocheV Obry-RoguetM OrticoniE RessiotA RitlengT Rojas-RojasO Zaegel-FaucherAndré CabieS AbelJ BavayB BigeardO CabrasLise CuzinR Dupin de MajoubertL FagourK GuitteaudM LehouxC MontagnacS Pierre-FrançoisK RomeJ TurmelJ ReynesN AtouiM BistoquetE DelaporteV Le MoingJ LejeuneA MakinsonN MeftahC Merle de BoeverB MontesA Montoya FerrerE TuaillonB LefèvreM AndréG BaronnetS BevilacquaL BoyerM BouillonA CharmillonM DelestanE FrentiuF GoehringerS HénardE JeanmaireC RabaudA Radjabaly-MandjeeF RaffiClotilde AllavenaE André-GarnierA Asquier-KhatiE BillaudC BironB BonnetS BouchezD BoutoilleC Brunet-CartierM CavellecC DeschanvresV FerréB GaboritA GrégoireM GrégoireT JovelinM LefebvreR LecomteR MahotP MorineauE ParedesV ReliquetE André-GarnierS SécherA SoriaPascal PuglieseS BréaudM BuscotM CarlesD ChirioE CuaP DellamonicaE DemonchyA de MonteJ DurantS FerrandoR GarraffoC MichelangeliA NaqviI PerbostC PradierB Prouvost-KellerK RissoI TouitouA ViotS Wehrlen-PuglieseL HocquelouxC GubavuV LegrosF PeiraT PrazuckV RzepeckiA SèveA CheretA Barrail-TranA CastroR ColarinoC GoujardS JaureguiberryY QuertainmontE TeicherV JolyC CharpentierD DescampsM DigumberA GervaisJ GhosnZ JuliaR LandmanS LarivenS Le GacF LouniG PeytavinC RiouxY YazdanpanahClaudine DuvivierK AmazzoughG BenabdelmoumenP BossiG CessotC CharlierP ConsignyE Gomes-PiresK JidarE LafontF LanternierO LortholaryC LouisinJ LourencoC MelenotteP ParizeA PouvaretC RouzaudA SerrisF TouamC KatlamaR AgherC BlancY DudoitN HamaniN QatibI QzaibriL LenclumeRomain PalichL SchneiderS SeangR TubianaM ValantinF Bani-SadrM BermejoJ BergerS DemotierM HentzienG JulienI KmiecD LambertH MartyY N’guyenJ RomaruC ArvieuxM BaldeyrouF BenezitJ ChapplainM DupontJ DuthéT JovelinA LebotF LemaitreA MaillardC MorlatS Patrat-DelonM Poisson-VannierC PronierM RevestJ SinteffF SoualaP TattevinA Gagneux-BrunonE Botelho-NeversA FrésardF LuchtV RonatD ReyC CheneauC Bernard-HenryE de MautortS Fafi-KremerP FischerP GantnerC MélounouM PartisaniP DelobelM AlvarezN BiezunskiA DebardC DelpierreC GarnierG GaubeL LelièvreM MarcelG Martin-BlondelM PiffautL PorteK SauneO RobineauE AïssiF AjanaI AlcarazE AlidjinouV BacletL BocketA BoucherV DerdourM GilbertT HuleuxB Lafon-DesmursA MeybeckM PradierM TetartP ThillM ValetteN VigetG Corvaisier
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Abstract Objectives To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL). Patients and methods Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL < 50 copies/mL) they had a minimum of two additional VL measurements. Cox models adjusted for sex, age, acquisition group, hepatitis B or C coinfection, place of birth, year of ART initiation, CD4+ T cells and VL at ART initiation, duration of known HIV infection and of ART regimen were used to assess the association between the time to VF and the occurrence of LLVL. ART regimen was evaluated as time-varying covariate. Results LLVL was described in 13.7% and VF in 11% of the 3302 patients. LLVL was associated with VF [adjusted HR (aHR) 1.76, 95% CI 1.28–2.41], as well as age (aHR 0.97/year, 95% CI 0.96–0.98), CD4+ T cell count at ART initiation (aHR 0.93, 95% CI 0.87–0.98), heterosexual transmission (aHR 1.76, 95% CI 1.30–2.37) and being born abroad (aHR 1.50, 95% CI 1.17–1.93). Conclusions LLVL was related to VF. Even in the absence of subsequent failure, LLV episodes have a cost. Thus any VL value above 50 copies/mL should lead to enhanced adherence counselling.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Boris SorinMichele IudiciMary-Jane GuerryMaxime SamsonPhilip BielefeldThibault MailletMathilde NouvierAlexandre KarrasLara MeyerChristian LavigneAlexis RégentCécile-Audrey DurelMarc FabrePierre CharlesQuentin RaimbourgAurélia LanteriGrégory PugnetFrédéric RivièreMarc Pineton De ChambrunPatrice CacoubGuillaume Le GuennoPierre JourdainArsène MekinianRomain PauleJérémie DionPaul LegendrePascal CohenLoïc GuillevinXavier PuéchalBenjamin Terrier
• Organismes : Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière]
• Publié dans Rheumatology (Oxford, England) le 24/03/2022

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Source

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• Type de publi. : Rapport
• Date de publi. : 16/12/2022
• Auteurs : Florence GuillotAdeline BéaPascal Robert-Cols
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés CAUE 81 ACCA

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Fichiers liés : Cordes(81)-Ormeaux 2022 prefigur 2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Felipe ReyesSrinivas MurthyEsteban Garcia-GalloLaura MersonElsa Ibáñez-PradaJordi RelloYuli FuentesIgnacio Martin-LoechesFernando BozzaSara DuqueFabio TacconeRobert FowlerChristiana KartsonakiBronner GonçalvesBarbara Wanjiru CitarellaDiptesh AryalErlina BurhanMatthew CummingsChristelle DelmasRodrigo DiazClaudia Figueiredo-MelloMadiha HashmiPrasan Kumar PandaMiguel Pedrera JiménezDiego Fernando Bautista RinconDavid ThomsonAlistair NicholJohn MarshallPiero OlliaroAli AbbasSheryl Ann AbdukahilRyuzo AbeLaurent AbelLara AbsilSubhash AcharyaAndrew AckerDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliNaseem Ali ShahKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesJoana Alves CabritaMaria AmaralPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioNamra AsifMohammad AsimJean Baptiste AssieAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrNadia BaigJ. 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MartinGuillaume Martin-BlondelMartin MartinotAna MartinsJoão MartinsNuno MartinsCaroline Martins RegoGennaro MartucciOlga MartynenkoEva Miranda MarwaliDavid MasloveSabina MasonSobia MasoodBasri Mat NorBasri Mat NorMoshe MatanMeghena MathewDaniel MathieuMathieu MatteiRomans MatulevicsLaurence MaulinMichael MaxwellJavier MaynarThierry MazzoniNatalie Mc EvoyLisa Mc SweeneyColin McarthurColin McarthurAine MccarthyAnne MccarthyColin MccloskeyRachael McconnochieSherry McdermottSarah McdonaldAine McelroySamuel McelweeVictoria MceneanyAllison McgeerChris MckayJohnny MckeownKenneth McleanPaul McnallyBairbre McnicholasElaine McpartlanEdel MeaneyCécile Mear-PassardMaggie MechlinMinahel AtifMaqsood MeherFerruccio MeleLuis MeloKashif MemonJoao Joao MendesOgechukwu MenkitiKusum MenonFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreBlake MerglerAntónio MesquitaOsama MetwallyAgnès MeybeckDan MeyerAlison MeynertVanina MeysonnierAmina MezianeMehdi MezidiCéline MichelangleiIsabelle MicheletVladislav MihnovitAsma MoinDavid MolinaElena MolinosBrenda MolloyMary MoneAgostinho MonteiroClaudia MontesGiorgia MontrucchioSarah MooreShona MooreLina Morales CelyLucia MoroCatherine MotherwayAna MotosHugo MouquetClara Mouton PerrotJulien MoyetAisha Kalsoom MuftiJimmy MullaertFredrik MüllerKarl Erik MüllerDaniel MunblitSyed MuneebNadeem MunirAisling MurphyAisling MurphyLorna MurphyMarlène MurrisHimed MusaabHimasha MuvindiDimitra Melia MyrodiaFarah Nadia Mohd-HanafiahDave NagpalAlex NagrebetskyNageswaran NarayananRashid Nasim KhanAlasdair Nazerali-MaitlandNadège NeantNikita NekliudovRaul NetoEmily NeumannPauline Yeung NgAnthony NghiDuc NguyenOrna Ni ChoileainNiamh Ni LeathlobhairPrompak NitayavardhanaStephanie NonasMarion NoretLisa NormanAlessandra NotariMahdad NoursadeghiAdam NowinskiSaad NseirJose NunezNurnaningsih NurnaningsihElsa NyamankollyFionnuala BrienAnnmarie CallaghanAnnmarie O’callaghanGiovanna OcchipintiDerbrenn OconnorMax O’donnellTawnya OgstonTakayuki OguraSophie O’halloranKatie O’hearnJoão OliveiraLarissa OliveiraDavid OngWilna OosthuyzenAnne OpavskyPeter OpenshawSaijad OrakzaiClaudia Milena Orozco-ChamorroJamel OrtolevaJavier OsatnikLinda O’sheaMiriam O’sullivanNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesAmanda PalaciosMario PalaciosMassimo PalmariniGiovanna PanarelloHem PaneruMauro PanigadaNathalie PansuAurélie PapadopoulosRachael ParkeMelissa ParkerBriseida ParraTaha PashaJérémie PasquierBruno PasteneFabian PataunerLuís PatrãoPatricia PatricioJuliette PatrierLisa PattersonRajyabardhan PattnaikChristelle PaulMical PaulJorge PaulosWilliam PaxtonJean-François PayenFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezLuis PerielThomas PerpointAntonio PesentiVincent PestreLenka PetrouMichele PetrovicVentzislava Petrov-SanchezFrank Olav PettersenGilles PeytavinScott PharandWalter PicardOlivier PiconeCarola PierobonDjura PiersmaCarlos PimentelRaquel PintoCatarina PiresIsabelle PironneauLionel PirothRiinu PiusLaurent PlantierJulien PoissyRyadh PokeerbuxSergio PoliGeorgios PollakisDiane PonscarmeAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaSébastien PreauChristian PrebensenJean-Charles PreiserAnton PrinssenMark PritchardGamage Dona Dilanthi PriyadarshaniLucia ProençaSravya PudotaOriane PuéchalBambang Pujo SemediMathew PulickenGregory PurcellLuisa QuesadaVilmaris Quinones-CardonaVíctor Quirós GonzálezElse Quist-PaulsenMohammed QuraishiChristian RabaudEbenezer RabindrarajanAldo RafaelMarie RafiqArsalan RahutullahFernando RainieriPratheema RamachandranNagarajan RamakrishnanJosé RamalhoBlandine RammaertGrazielle Viana RamosAsim RanaRajavardhan RangappaRitika RanjanChristophe RappAasiyah RashanThalha RashanGhulam RasheedMenaldi RasminIndrek RätsepCornelius RauAli RazaAndre RealStanislas RebaudetSarah RedlBrenda ReeveAttaur RehmanLiadain ReidLiadain ReidDag Henrik ReikvamRenato ReisJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaTiago ReyesMaria Ines RibeiroDavid RichardsonDenise RichardsonLaurent RichierJordi RieraAna RiosAsgar RishuPatrick RispalKarine RissoNicholas RizerChiara RobbaAndré RobertoStephanie RobertsDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaJulia Rodriguez AbreuBernhard RoesslerPierre-Marie RogerAmanda RojekJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerAndrea RossaneseMatteo RossettiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaeve RyanMaria RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaSairah SadafMusharaf SadatValla SahraeiNadia SaidaniMaximilien Saint-GillesPranya SakiyalakNawal SalahuddinLeonardo SalazarJodat SaleemGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineOana SandulescuMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroBenjamine SartonSree SatyapriyaRumaisah SatyawatiEgle SaviciuteJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderStephan SchrollMichael SchwameisJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzJaganathan SelvanayagamCaroline SemailleMalcolm SempleEric SennevilleFilipa SequeiraTânia SequeiraAry Serpa NetoPablo Serrano BalazoteEllen ShadowitzMohammad ShamsahShaikh SharjeelPratima SharmaCatherine ShawVictoria ShawAshraf SheharyarRajesh Mohan ShettyHaixia ShiMohiuddin ShiekhKeiki ShimizuSally ShrapnelShubha Kalyan ShresthaPramesh Sundar ShresthaHoi Ping ShumNassima Si MohammedJeanne SibiudeAtif SiddiquiLouise SigfridPiret SillaotsCatarina SilvaMaria Joao SilvaRogério SilvaWai Ching SinBudha Charan SinghPunam SinghPompini Agustina SitompulVegard SkogenSue SmithBenjamin SmoodCoilin SmythMichelle SmythMichelle SmythMorgane SnackenDominic SoJoshua SolomonTom SolomonEmily SomersAgnès SommetMyung Jin SongRima SongTae SongJack Song ChiaAlbert SottoEdouard SoumAna Chora SousaMarta SousaMaria Sousa UvaAlexandra SperryElisabetta SpinuzzaB. DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicMagdalena SurovcováAndrey SvistunovKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziLysa TaghersetSara TalebJelmer TalsmaMaria Lawrensia TampubolonHiroyuki TanakaHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM. Azhari TaufikHassan TawfikRichard TedderJoão TeixeiraSofia TejadaMarie-Capucine TellierFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAnand ThakurVincent ThibaultSimon-Djamel ThibervilleBenoît ThillShaun ThompsonEmma ThomsonRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitBharath Kumar Tirupakuzhi VijayaraghavanNoémie TissotMaria TokiKristian TonbyMarta TorreAntoni TorresMargarida TorresHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtlePawel TwardowskiMakoto UchiyamaP. UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfLaura van GulikJarne van HattemCarolien van NettenIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseCharline VauchyAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoBenoit VisseauxHannah VisserChiara VitielloHarald VonkemanFanny VuottoWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsNg Wing YiuCalvin WongIoannis XynogalasMasaki YamazakiYazdan YazdanpanahCécile YelnikStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeMaram ZahranMaria ZambonAlberto ZanellaHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : University of Oxford University of La Sabana = Universitad de la Sabana University of Oxford ARN régulateurs bactériens et médecine CHU Pontchaillou [Rennes]
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Gemma LlauradóBogdan VlachoMatthieu WargnyYue RuanJosep Franch-NadalPere DomingoPierre GourdyPierre-Jean SaulnierSamy HadjadjSarah WildRustam ReaBertrand CariouKamlesh KhuntiDídac MauricioJuan Antonio ArroyoJuan-José ChillarónRosa CorcoyRoberto GüerriManel Mata-CasesEmilio OrtegaMatthieu PichelinMaëva SaignesJeanne SaunierSelma El AndaloussiJoëlle Martin-GauthierEmily RebouilleauTanguy RomanPascale MahotMatthieu PichelinAnne-Laure Fournier-GuillouxNicolas MauduitEdith Bigot- CorbelAnne-Sophie BoureauLaure de DekcerAudrey ErnouldClaire PrimotAnne SeguinMarielle JoliveauSonia PouvreauChloé FournierJeremy ThureauEdith FonteneauPamela HublainCarole AgasseMathilde de KergaradecVincent MinvilleFanny Vardon-BounesGuillaume Martin-BlondelBlandine TramuntMarie-Christine TurninHélène HanaireJean-Michel MansuyDidier FabreMarie-Blanche ArhainxLaurent CazalsLaure CombesEmmanuelle LamiBruno MégarbanePierre LeroyJean-François GautierTiphaine Vidal-TrecanJean-Pierre RivelineJean-Louis LaplancheStéphane MoulyLouis PotierRonan RousselMalak TaherYawa AboulekaFetta YakerAurelie CarlierAnne BouttenMarilyne Hallot-FeronFadila MourahCharles ThivoletEmilie BlondMuriel RollandJosep Verdecho MendezMarine AlexandreJulien PottecherEmilie RicherLaurent MeyerFlorina LucaJean-Marc LessingerThibault BahougneBruno GuerciSiham BenzirarCatherine MalaplateThierry MattonJulien PoissyKarine FaurePierre FontaineFlorence BaudouxAnne VambergueJean David PekarMarc LambertCécile YelnikAmélie BruandetLaurent PetitDidier NeauVincent RigalleauAnnie BerardAmandine GaliootRemy CoudroyArnaud ThilleRené RobertFrance Roblot-CazenaveBlandine RammaertPierre Jean SaulnierXavier PiguelNesrine BenhendaCamille HussonCeline OlivierFlorence TorremochaMathilde FratyMarie Flamen D’assignyAurelie MiotValentin BossardKada KloucheAlain MakinsonAriane SultanJean-Baptiste BonnetVincent FoulongneFlorence GaltierCécile AubronSéverine AnsartVéronique KerlanPascale QuiniouJean- Luc CarreStéphane QuesnotBruno LaviolleCarole SchwebelOlivier EpaulardPierre-Yves BenhamouCécile BétryAnne-Laure BorelSandrine LablancheDorra GuergourCatherine DuclosEmmanuel CossonErwan GuyotAurore DeniauPhucthutrang NguyenYves ReznikMichael JoubertStéphane AlloucheLydia GuittetSteven GrangeManuel EtienneGaëtan PrévostValéry BrunelJean-Christophe LagierDidier RaoultAnne DutourBénédicte GaboritSandrine BoullluPatrice DarmonAdèle LasbleizMathieu CerinoFanny RomainMarie HoussaysJean-Pierre QuenotLionel PirothBruno VergèsLaurence DuvillardBernard BonnotteAlain MercatVincent DubeeIngrid AllixPatrice RodienRobin DhersinMaylis LebeaultWojciech TrzepizurJocelyne LoisonAntoine BrangierPierre AsfarPascal ReynierFrançoise LarcherFrançoise JoubaudMarie-Rita AndreuGeoffrey UrbanskiLaurent HubertCédric AnnweilerJean DellamonicaJohan CourjonNicolas ChevalierGiulia ChinettiMagda ChafaiBruno MourvillierFirouze Bani-SadrSarra BarraudBrigitte DelemerPhilippe GilleryPascale LabedadeAmélie ChabrolAlfred PenfornisCatherine PetitCoralie AmadouMaxime AdlerClément DubostPierre-Louis ConanLyse BordierFranck CeppaCyril GarciaMathilde SollierOlivier DupuySophie LaplanceOlivier BilluartMarie Joseph AroulandaFrédérique OlivierFlorence AyonNathalie WilhelmLoic EpelboinNadia SabbahAurelie CharpinPierre SquaraOlivier BelliardClaude DuboisMichel MarreJohann AuchabieRoxane CourtoisThierry DuriezTiphaine MergeyLaura ValleeLaetitia SeguinAbdallah Al-SalamehJean-Philippe LanoixSandrine Soriot-ThomasAnne-Marie Bourgeois-DescoulsRachel DesailloudNatacha GermainBogdan GaluscaGwenaelle BelletonNesrine MarouaniDelia PalaghiuAmira HammourFernando BerdaguerThimothée KlopfensteinHajer ZayetPatrice WiniszewskiMarie ZanussoPauline GarnierIngrid JulierKarim HamzaouiSophie Marty-GresTarik El SadkiLucile CadotJean-Louis DubostCéline GonfroyCatherine CampinosPascale MartresMarie Pierre CoulhonNicolas AllouMarwa BachirStella HoangCandice KembellecOlivia SuplyFatima KharchaAnne-Claire DevougeAnna Flaus-FurmanukIsabelle MadelineVincent EhingerSophie BastardLoic RaffrayFrederic RenouAude BojarskKarine BorsuAngelique GorlinServane Di BernardoCarole Truong van UtStephane RenaudAntoine VignolesEmilie FochLaurie MasseHubert GrandHelene FerrandChristelle Raffaitin-CardinHadjer ZellaguiCeline Castang-BrachetFrederique BouryAna Alvarez TenaIsabelle MouraPierre KalfonLouis PasteurJuliana DarasteanuLouis PasteurArnaud MonierLouis PasteurPascal FoucaultLouis PasteurAlexandra DepuilleLouis PasteurStéphanie Laugier-RobiollePatrick CaneiroMaud BassoEtienne LargerSamir BouamWahiba BenzenatiLeila Ait BachirCamille Cussac PillegandMarc VasseChristophe MichardNathanaëlle MontanierLuc MillotFrançoise CrepetDanielle RatsimbaKevin BouillerSophie BorotIsabelle BruckertAnnie ClergeotFranck SchilloDorothée VignesMuriel Bourgeon-GhittorilachgarClaire Lambert de CursayStéphane LevanteJean Charles AureganAntoine MerletCécile ZaragozaGwénaëlle ArnaultAnne-Gaëlle Le LouppOlivier LesieurMariam Roncato-SaberanDidier GouetRomain LemariHong-An AllanoEmmanuel VivierCaroline ParisetCédric LuytonLucien MarchandFanny DoroszewskiMatthieu PecquetLaurent PerardSylvie Vuillermoz-BlasNicolas KackiPatricia CharrierAmélie Ducet-BoiffardFrançoise Desroys Du RoureOlivier BourronDominique Bonnefont-RousselotSuzanne LarocheFranck PhanAgnès HartemannCyrielle CaussyEmmanuel DisseEmilie BlondClaude GuerinThomas PerpointPhilippe MoulinRégine CartierGeoffroy HaririDorothée ChopinCamille VatierNathalie BourcigauxEmmanuelle ChaigneauSophie Christin-MaitreBruno DonadilleBruno FèveSophie LamotheJulie SarfatiPascal PernetAnne ChambonDelphine DemarsyHugo CampagneFrançoise Latil-PlatMonica BerneMarilyne GrinandMarion TouzetAydrey ZabulonJocelyne CraspagCatherine LedouxCédric ContaretBlandine Janand-DelenneAnaïs GiraudMarie Lou LacriminiJoëlle ArrivieDeborah AncelleCarine GuilloisBénédicte FremyAmina ChaalalGaëlle BarrandeAnne DorangeEglantine RouanetDominique Seret-BegueAudrey SaoudAnne-Marie GuedjNathalie BedosFritz-Line VelayoudomMarie DumasBenoite GondaChristine CoffinStéphanie GibiatMyriam LungoChantal BullyPierre SerusclatStella BullyPatricia CarreJean-Philippe LeberreCarlos ElkhouryMarine ThieuxLaetitia Paradisi-PrieurEmma WilmotSarah WildBen FieldParth NarendranRajiv GandhiSophie HarrisDinesh NagiRobert RyderJim DaviesSteve HarrisOliver FreemanBen MaylorKinga VárnaiGail RoadknightMelissa CulAmy EdwardsSusan GeldingKirun GunganahPyei AungMoulinath BanerjeeAli ChakeraDominique RouseSyed Haris AhmedHo Yee CheungHywel RobertsSusan SealSyed Saah ShahAmir HayatCynthia MohandasHtet Htet AungSu Khant ChelNyan LinKavitia NarulaFurruq QuadriSu Lei YinYin YinAlamin AlkundiAbdelmajid MusaEmma BirbeckCharles BodmerIrene BossmanSathis KumarUmesh DashoraElizabeth ToubiMansoor ZafarVinod PatelAmitha GopinathBelinda AllanRemat KarimDharshana AppuhamillageKhubaib AyoubSophie HarrisCharmaine IlangaratneMaliha IqbalRory MacleanOmar MustafaSusan BaxterMalgorzata AdamusKevin BaynesSiva SivappriyanRyan D’costaDinesh NagiVernon ParfittMazharul IslamSadia NasirGail RoadknightKinga VárnaiSenthil VasanVilashini Arul DevahFoteini KavvouraLina FickenJames GilhamVincent SimpsonNeil WalkerUmaira AzizEfthimia KarraDipesh PatelMiranda RosenthalTracy CurranAngela PaisleyMelissa CullParijat de PMay Thin KhinePari QayyamRobert RyderPriscilla SarkarRajiv GandhiBen FieldJames ClarkVesna HoganLauren JacksonJamie-Leigh WilliamsonR. YounesLucy RobinLydia GrixtiSuann TeeAbilash SathyaEmma WilmotMayank PatelCatherine HolmesWasim HanifSandip GhoshParth NarendranEhtasham AhmadEjaz AhmedMelanie DaviesSteven HartshornKamlesh KhuntiLee SimonsDavid WebbBen MaylorJim DaviesOliver FreemanSteve HarrisAnupam BrahmaSeshadri PramodhKaty FrewAlison MackenzieAbigail WildHelen CaseyDeborah MorrisonConor MckeagAnne SillarsAngus StirlingFiona SmeetonSyed MuhammadKofi ObuobieWin YinNeera AgarwalMike AtkinsonSai AmbatiRahim KhanPreethi NallaArshiya TabasumStamatios ZourasAkhila MallipedhiRichard ChudleighDavid WilliamsMallory CianferaniLisa LudwigCaroline PaulHamoud Lachgar
• Organismes : INSERM UMRS-1144, Université Paris Cité, Réanimation Médicale et Toxicologique, Hôpital Lariboisière
• Publié dans Cardiovascular Diabetology le 23/10/2020

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Résumé : Abstract Background It is not clear whether pre-existing macrovascular complications (ischemic heart disease, stroke or peripheral artery disease) are associated with health outcomes in people with diabetes mellitus hospitalized for COVID-19. Methods We conducted cohort studies of adults with pre-existing diabetes hospitalized for COVID-19 infection in the UK, France, and Spain during the early phase of the pandemic (between March 2020—October 2020). Logistic regression models adjusted for demographic factors and other comorbidities were used to determine associations between previous macrovascular disease and relevant clinical outcomes: mortality, intensive care unit (ICU) admission and use of invasive mechanical ventilation (IMV) during the hospitalization. Output from individual logistic regression models for each cohort was combined in a meta-analysis. Results Complete data were available for 4,106 (60.4%) individuals. Of these, 1,652 (40.2%) had any prior macrovascular disease of whom 28.5% of patients died. Mortality was higher for people with compared to those without previous macrovascular disease (37.7% vs 22.4%). The combined crude odds ratio (OR) for previous macrovascular disease and mortality for all four cohorts was 2.12 (95% CI 1.83–2.45 with an I 2 of 60%, reduced after adjustments for age, sex, type of diabetes, hypertension, microvascular disease, ethnicity, and BMI to adjusted OR 1.53 [95% CI 1.29–1.81]) for the three cohorts. Further analysis revealed that ischemic heart disease and cerebrovascular disease were the main contributors of adverse outcomes. However, proportions of people admitted to ICU (adjOR 0.48 [95% CI 0.31–0.75], I 2 60%) and the use of IMV during hospitalization (adjOR 0.52 [95% CI 0.40–0.68], I 2 37%) were significantly lower for people with previous macrovascular disease. Conclusions This large multinational study of people with diabetes mellitus hospitalized for COVID-19 demonstrates that previous macrovascular disease is associated with higher mortality and lower proportions admitted to ICU and treated with IMV during hospitalization suggesting selective admission criteria. Our findings highlight the importance correctly assess the prognosis and intensive monitoring in this high-risk group of patients and emphasize the need to design specific public health programs aimed to prevent SARS-CoV-2 infection in this subgroup.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Ali AbbasSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelLara AbsilKamal Abu JabalHiba Abu ZayyadSubhash AcharyaAndrew AckerShingo AdachiElisabeth AdamEnrico AdrianoDiana AdriãoSaleh Al AgeelShakeel AhmedMarina AielloKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimTala Al-DabbousAbdulrahman Al-FaresRazi AlalqamAngela AlbertiSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreHuda AlfoudriAdam AliImran AliNaseem Ali ShahNaseem Ali SheikhKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesMaria AmaralNur AmiraHeidi AmmerlaanPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoKazi Rubayet AnwarArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayAna ArocaLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalMotohiro AsakiAngel AsensioElizabeth AshleyMuhammad AshrafNamra AsifMohammad AsimJean Baptiste AssieAmirul AsyrafAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenNadia BaigJ. Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanValeria BalanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaAudrey BarreletCleide BarrigotoMarie BartoliCheryl BartoneJoaquín BaruchMustehan BashirRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillKarine BeirutiAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanDehbia BenkerrouSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisAdam BetzSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarIsabella BianchiClaudia BiancoFarah Nadiah BidinMoirangthem Bikram SinghFelwa Bin HumaidMohd Nazlin Bin KamarudinFrançois 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RyanMazankowski Heart Institute RyckaertSteffi RyckaertAleksander Rygh HoltenIsabela SabaLuca SacchelliSairah SadafMusharaf SadatValla SahraeiNadia SaidaniMaximilien Saint-GillesPranya SakiyalakNawal SalahuddinLeonardo SalazarJodat SaleemNazal SalehGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezXavier Sánchez ChoezKizy Sanchez de OliveiraAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineOana SandulescuMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroIam Claire E. 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DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelSamantha StrudwickAmi StuartDavid StuartDecy SubektiGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováSuwarti SuwartiAndrey SvistunovSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziFabio TacconeLysa TaghersetShahdattul Mawarni TaibEwa TalarekSara TalebJelmer TalsmaRenaud TamisierMaria Lawrensia TampubolonKim Keat TanLe Van TanYan Chyi TanClarice TanakaHiroyuki TanakaTaku TanakaHayato TaniguchiHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikRichard TedderTze Yuan TeeJoão TeixeiraSofia TejadaMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitAnand ThakurZhang Duan ThamSuvintheran ThangaveluVincent ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonDavid ThomsonEmma ThomsonSurain Raaj Thanga ThuraiDuong Bich ThuyRyan ThwaitesAndrea TicinesiPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitBharath Kumar Tirupakuzhi VijayaraghavanNoémie TissotJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiAntoni TorresMargarida TorresRosario Maria Torres Santos-OlmoHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxHuynh Trung TrieuCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtleAnders TveitaPawel TwardowskiMakoto UchiyamaP UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresPiero ValentiniAna Luiza ValleAmélie ValranIlaria ValzanoStijn van de VeldeMarcel van den BergeMachteld van der FeltzJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfMarlice van DykLaura van GulikJarne van HattemCarolien van NettenGitte van TwillertIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseMichael VarroneShoban Raj VasudayanCharline VauchyShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoNguyen van Vinh ChauGayatri VishwanathanBenoit VisseauxHannah VisserChiara VitielloManivanh VongsouvathHarald VonkemanFanny VuottoNoor Hidayu WahabSuhaila Abdul WahabNadirah Abdul WahidMarina WainsteinWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilTan Pei WenSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsCalvin WongTeck Fung WongXin Ci WongYew Sing WongNatalie WrightGan Ee XianLim Saio XianKuan Pei XuanIoannis XynogalasSophie YacoubSiti Rohani Binti Mohd YakopMasaki YamazakiYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichTouxiong YiayeToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid ZucmanEsteban Garcia-GalloLaura MersonKalynn KennonSadie KellyBarbara Wanjiru CitarellaDaniel Vidali FryerSally ShrapnelJames LeeSara DuqueYuli FuentesValeria BalanSue SmithJia WeiBronner GonçalvesClark RussellLouise SigfridAndrew DagensPiero OlliaroJoaquin BaruchChristiana KartsonakiJake DunningAmanda RojekAasiyah RashanAbi BeaneSrinivas MurthyLuis Felipe Reyes
• Organismes : Imagine - Institut des maladies génétiques (IHU) CHU Pontchaillou [Rennes] ARN régulateurs bactériens et médecine University of La Sabana = Universitad de la Sabana University of Queensland [Brisbane] University of British Columbia University of La Sabana = Universitad de la Sabana University of Oxford
• Publié dans Scientific Data le 29/10/2020

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Résumé : The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.

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Fichiers liés : s41597-022-01534-9.pdf

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