Pascal Fabre

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• Type de publi. : Article dans une revue
• Date de publi. : 20/02/2024
• Auteurs : Nicolas NesselerAlexandre MansourMatthieu SchmidtMarylou ParaAlizée PortoPierre-Emmanuel FalcozNicolas MongardonClaire FougerouJames RossAntoine BeurtonLucie Gaide-ChevronnayPierre-Grégoire GuinotGuillaume LebretonErwan FlecherAndré VincentelliNicolas MassartOlivier FouquetMarc PierrotSidney ChocronGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerRaphel BellaïcheOphélie ConstantQuentin de RouxL. AndréArnaud MeffertJean-Claude MerleLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas D’ostrevyMarie-Catherine MorganMaxime NguyenNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreJulien GuihaireIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaSabrina ManganielloAgnes MugnierNatacha RousseOlivier DesebbeJean-Luc FellahiRoland HenaineMatteo PozziZakaria RiadChristophe GuervillySami HraiechLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroPhilippe GaudardKais BriniNicolas BischoffAntoine KimmounBruno LevyPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéBertrand RozecMickaël Vourc’hStéphane AubertFlorian BazalgetteClaire RogerPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchereMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiBernard CholleyYannis GuyonvarchSophie HamadaClaudio BarbantiAstrid BertierAnatole HarroisJordi MatielloThomas KerforneCorentin LacroixNicolas BrechotAlain CombesJuliette ChommelouxCosimo D’alessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HekimianCharles JuvinPascal LeprinceDavid LevyCharles Edouard LuytThibaut SchoellPierre FillâtreMaud JonasNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierAmedeo AnselmiKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizineMaxime EsvanPhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierAnne OllandMarion VillardFanny BounesFrançois LabasteVincent MinvilleAntoine GuillonYannick Fedun
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer Institut de recherche en santé, environnement et travail Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Laboratoire de Recherche Vasculaire Translationnelle Assistance Publique - Hôpitaux de Marseille Nanomédecine Régénérative Institut Mondor de Recherche Biomédicale Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou] Centre d'Investigation Clinique [Rennes] Case Western Reserve University [Cleveland] Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Centre Hospitalier Universitaire [CHU Grenoble] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou] Laboratoire Traitement du Signal et de l'Image Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 Centre hospitalier Saint-Brieuc
• Publié dans Critical Care le 31/10/2020

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Résumé : Background Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI). However, data on incidence, microbiology, resistance patterns, and the impact of HAI on outcomes in patients receiving ECMO for severe COVID-19 remain limited. We aimed to report HAI incidence and microbiology in patients receiving ECMO for severe COVID-19 and to evaluate the impact of ECMO-associated infections (ECMO-AI) on in-hospital mortality. Methods For this study, we analyzed data from 701 patients included in the ECMOSARS registry which included COVID-19 patients supported by ECMO in France. Results Among 602 analyzed patients for whom HAI and hospital mortality data were available, 214 (36%) had ECMO-AI, resulting in an incidence rate of 27 ECMO-AI per 1000 ECMO days at risk. Of these, 154 patients had bloodstream infection (BSI) and 117 patients had ventilator-associated pneumonia (VAP). The responsible microorganisms were Enterobacteriaceae (34% for BSI and 48% for VAP), Enterococcus species (25% and 6%, respectively) and non-fermenting Gram-negative bacilli (13% and 20%, respectively). Fungal infections were also observed (10% for BSI and 3% for VAP), as were multidrug-resistant organisms (21% and 15%, respectively). Using a Cox multistate model, ECMO-AI were not found associated with hospital death (HR = 1.00 95% CI [0.79–1.26], p = 0.986). Conclusions In a nationwide cohort of COVID-19 patients receiving ECMO support, we observed a high incidence of ECMO-AI. ECMO-AI were not found associated with hospital death. Trial registration number NCT04397588 (May 21, 2020).

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Fichiers liés : 13054_2024_Article_4832.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Boris AmoryClaire GoumardAlexis LaurentSerena LangellaDaniel CherquiEphrem SalameLouise BarbierOlivier SoubraneOlivier FargesChristian HobeikaTakayuki KawaiJean-Marc RegimbeauFrançois FaitotPatrick PessauxStéphanie TruantEmmanuel BoleslawskiAstrid HerreroJean-Yves MabrutLaurence ChicheMarcello Di MartinoRami RhaiemLilian SchwarzVivian ResendeJulien CalderaroJérémy AugustinStefano CarusoDaniele SommacaleStefan HofmeyrAlessandro FerreroDavid FuksEric VibertGuido TorzilliOlivier ScattonRaffaele BrustiaJulio AbbaRené AdamMustapha AdhamPietro AddeoMarc-Antoine AllardGiuliana AmaddeoAhmet AyavDaniel AzoulayPhilippe BachellierPierre BalladurJulien BarbieuxEmmanuel BoleslawskiKarim BoudjemaM. BougardEmmanuel BucPetru BucurAntoine CarmeloFrançois CauchyDenis ChatelainJean ChauvatZineb CherkaouiMircea ChiricaOriana CiacioTatiana CodjiaFabio ColliLuciano de CarlisJean-Robert DelperoNicolas DemartinesOlivier DetryMarcelo Dias SanchesMomar DioufAlexandre DoussotChristian DucerfMehdi El AmraniJacques EwaldJean-Marc FabreHervé FagotSimone FamularoLéo FerreFrancesco FleresGilton Marques FonsecaÁlvaro Gancedo QuintanaBrice GayetAlessandro GiacomoniJean-Francois GigotNicolas GolseEmilie GregoireJean HardwigsenPaulo HermanThevi HorFrançois JehaesAli-Reza KianmaneshShohei KomatsuSophie LarocheChristophe LaurentYves-Patrice Le TreutPhilippe LeourierEmilie LermiteMikael LesurtelChristian LetoublonPaul LeymanMickael LesurtelJean LubranoJean-Yves MabrutGeorges MantionUgo MarcheseElena Martín-PérezBenjamin MenahemMaxime MeunierGuillaume MilletKayvan MohkamAndré MulliriFabrice MuscariFrancis NavarroFrancisco NolascoTakeo NomiJean NunozGennaro NuzzoShinya OkumuraNassima OudafalGerard PascalGuillaume PassotDamiano PatronoFrançois PayeFabiano PerdigaoNiccolo PetruccianiGabriella PittauFrançois-René PruvotArtigas RaventosHélène RegnaultMichel RivoireRenato RomagnoliDidier RoulinAntonio Sa-CunhaMichel ScotteFrançois-Regis SoucheBertrand SucAlexandre ThobieBoris TrechotStéphanie TruantOlivier TuriniShinji UemotoXavier UnterteinerCharles VanbruggheJean Zemour
• Organismes : Centre de Recherche Saint-Antoine Service de chirurgie digestive Centre Hépato-Biliaire [Hôpital Paul Brousse] CHU Trousseau [Tours] Hôpital Haut-Lévêque - CHU de Bordeaux CHU Pitié-Salpêtrière [AP-HP] Institut Mutualiste de Montsouris Laboratoire d'Energétique et Mécanique Théorique et Appliquée Service de chirurgie hepato-pancreato-biliaire Simplification des soins chez les patients complexes - UR UPJV 7518 Chirurgie digestive [CHU Amiens] Hôpital de Hautepierre [Strasbourg] Institute for Translational Medicine and Liver Disease Institut de Recherche sur les Maladies Virales et Hépatiques Service de chirurgie hepato-pancreato-biliaire Hôpital Claude Huriez [Lille] Hôpital Gui de Chauliac [CHU Montpellier] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Haut-Lévêque - CHU de Bordeaux Université Paris-Est Créteil Val-de-Marne - Faculté de médecine IMRB - VHC/"Viruses-Hepatology-Cancers" [Créteil]
• Publié dans Surgery le 31/10/2020

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Résumé : Background Combined hepatocholangiocarcinoma is a rare cancer with a grim prognosis composed of both hepatocellular carcinoma and intrahepatic cholangiocarcinoma morphologic patterns in the same tumor. The aim of this multicenter, international cohort study was to compare the oncologic outcomes after surgery of combined hepatocholangiocarcinoma to hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods Patients treated by surgery for combined hepatocholangiocarcinoma, hepatocellular carcinoma, and intrahepatic cholangiocarcinoma from 2000 to 2021 from multicenter international databases were analyzed retrospectively. Patients with combined hepatocholangiocarcinoma (cases) were compared with 2 control groups of hepatocellular carcinoma or intrahepatic cholangiocarcinoma, sequentially matched using a propensity score based on 8 preoperative characteristics. Overall and disease-free survival were compared, and predictors of mortality and recurrence were analyzed with Cox regression after propensity score matching. Results During the study period, 3,196 patients were included. Propensity score adjustment and 2 sequential matching processes produced a new cohort (n = 244) comprising 3 balanced groups was obtained (combined hepatocholangiocarcinoma = 56, intrahepatic cholangiocarcinoma = 66, and hepatocellular carcinoma = 122). Kaplan–Meier overall survival estimations at 1, 3, and 5 years were 67%, 45%, and 28% for combined hepatocholangiocarcinoma, 92%, 75%, and 55% for hepatocellular carcinoma, and 86%, 53%, and 42% for the intrahepatic cholangiocarcinoma group, respectively (P = .0014). Estimations of disease-free survival at 1, 3, and 5 years were 51%, 25%, and 17% for combined hepatocholangiocarcinoma, 63%, 35%, and 26% for the hepatocellular carcinoma group, and 51%, 31%, and 28% for the intrahepatic cholangiocarcinoma group, respectively (P = .19). Predictors of mortality were combined hepatocholangiocarcinoma subtype, metabolic syndrome, preoperative tumor markers alpha-fetoprotein and carbohydrate antigen 19-9, and satellite nodules, and recurrence was associated with satellite nodules rather than cancer subtype. Conclusion Despite data limitations, overall survival among patients with combined hepatocholangiocarcinoma was worse than both groups and closer intrahepatic cholangiocarcinoma, whereas disease-free survival was similar among the 3 groups. Future research on immunophenotypic profiling may hold more promise than traditional nonmodifiable clinical characteristics (as found in this study) in predicting recurrence or response to salvage treatments.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/01/2024
• Auteurs : Méline SaubinJérôme CovilleConstance XhaardPascal FreySamuel SoubeyrandFabien HalkettFrédéric Fabre
• Organismes : Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes Santé et agroécologie du vignoble
• Publié dans Peer Community Journal le 26/11/2021

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Résumé : Dispersal, and in particular the frequency of long-distance dispersal (LDD) events, has strong implications for population dynamics with possibly the acceleration of the colonisation front, and for evolution with possibly the conservation of genetic diversity along the colonised domain. However, accurately inferring LDD is challenging as it requires both large-scale data and a methodology that encompasses the redistribution of individuals in time and space. Here, we propose a mechanistic-statistical framework to estimate dispersal from one-dimensional invasions. The mechanistic model takes into account population growth and grasps the diversity in dispersal processes by using either diffusion, leading to a reaction-diffusion (R.D.) formalism, or kernels, leading to an integro-differential (I.D.) formalism. The latter considers different dispersal kernels (e.g. Gaussian, Exponential, and Exponential-power) differing in their frequency of LDD events. The statistical model relies on dedicated observation laws that describe two types of samples, clumped or not. As such, we take into account the variability in both habitat suitability and occupancy perception. We first check the identifiability of the parameters and the confidence in the selection of the dispersal process. We observed good identifiability for all parameters (correlation coefficient >0.9 between true and fitted values). The dispersal process that is the most confidently identified is Exponential-Power (i.e. fat-tailed) kernel. We then applied our framework to data describing an annual invasion of the poplar rust disease along the Durance River valley over nearly 200 km. This spatio-temporal survey consisted of 12 study sites examined at seven time points. We confidently estimated that the dispersal of poplar rust is best described by an Exponential-power kernel with a mean dispersal distance of 1.94 km and an exponent parameter of 0.24 characterising a fat-tailed kernel with frequent LDD events. By considering the whole range of possible dispersal processes our method forms a robust inference framework. It can be employed for a variety of organisms, provided they are monitored in time and space along a one-dimension invasion.

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• Type de publi. : Autre publication
• Date de publi. : 07/01/2024
• Auteurs : Pascal MartinY. J. DappeStéphane LenfantMaria Luisa Della RoccaVincent HucAmandine BellecBruno FabreFrédéric Chérioux
• Organismes : Interfaces, Traitements, Organisation et Dynamique des Systèmes CEA- Saclay Service de physique de l'état condensé Groupe Modélisation et Théorie Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Laboratoire Matériaux et Phénomènes Quantiques Institut de Chimie Moléculaire et des Matériaux d'Orsay Laboratoire Matériaux et Phénomènes Quantiques Institut des Sciences Chimiques de Rennes Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174)

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Fichiers liés : Chronique NEMO #3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Jean-Guillaume DillingerThéo PezelClément DelmasGuillaume SchurtzAntonin TrimailleNicolas PilieroClaire BouletiBenoît LattucaStéphane AndrieuJulien FabreReza Rossanaly VasramJean-Claude DibVictor AboyansCharles FauvelFrançois RoubilleEdouard GerbaudAlbert BoccaraEtienne PuymiratSolenn ToupinEric VicautPatrick HenryVictor AboyansEmeric AlbertFranck AlbertSean AlvainNabil AmriStéphane AndrieuSabir AttouSimon AuvraySonia AzzakaniRuben AzencotMarc BedossaFranck BoccaraAlbert BoccaraThomas BochatonEric Bonnefoy-CudrazGuillaume BonnetGuillaume BonnetNabil BoualiOcéane BouchotClaire BouletiTanissia BoukertoutaJean-Baptiste BretteMarjorie CanuAures ChaibClement CharbonnelAnne-Solene ChaussadeAlexandre CoppensYves CottinArthur DarmonElena de AngelisClément DelmasLaura DelsarteAntoine DeneyJean-Claude DibJean-Guillaume DillingerClemence DocqValentin DupasquierMeyer ElbazAntony El HadadAmine El OuahidiNacim EzzouhairiJulien FabreDamien FardCharles FauvelÉdouard GerbaudMartine GilardMarc GoralskiNissim GrinbergAlain GrentzingerMarie Hauguel-MoreauPatrick HenryFabien HuetThomas LandemaineBenoit LattucaLéo LemarchandThomas LevasseurPascal LimLaura Maitre BallesterosNicolas MansencalBenjamin MarieDavid MartinezBenoit MeratChristophe MeuneDamien MillischerThomas MoinePascal NhanNathalie NoirclercPatrick OhlmannThéo PezelFabien PicardNicolas PilieroThibaut PommierEtienne PuymiratArthur RamonatxoReza Rossanaly VasramFrançois RoubilleVincent RouleGuillaume SchurtzMathilde StevenardDavid SulmanFédérico SwedskyVictoria TeaEugénie ThevenetChristophe ThuaireAntonin TrimailleChristophe TronGuillaume ViboudDominique YomiCyril Zakine
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans EClinicalMedicine le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 26/12/2023
• Auteurs : Félix Camirand-LemyreLaura MersonBharath Kumar Tirupakuzhi VijayaraghavanAidan BurrellBarbara Wanjiru CitarellaMarie-Pier DomingueSimon LévesqueEffua UsufEvert-Jan WilsShinichiro OhshimoIgnacio Martin-LoechesOana SǎndulescuJon Henrik LaakeFrançois LamontagneSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelAmal AbrousLara AbsilKamal Abu JabalNashat Abu SalahAndrew AckerElisabeth AdamDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalChika AkwaniEman Al QasimRazi AlalqamAliya Mohammed AlameenAngela AlbertiTala Al-DabbousSenthilkumar AlegesanMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliAdam AliKazali Enagnon AlidjnouQabas AlkhafajeeClotilde AllavenaNathalie AllouJoão AlvesRita AlvesJoão Melo AlvesJoana Alves CabritaMaria AmaralNur AmiraRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariAngel AsensioElizabeth AshleyMuhammad AshrafJean Baptiste AssieAmirul AsyrafMinahel AtifAnika AtiqueAm Udara Lakshan AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayHakeem BabatundeBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenNadia BaigJohn Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaCleide BarrigotoMarie BartoliJoaquín BaruchRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarClaudia BiancoFarah Nadiah BidinFelwa Bin HumaidMohd Nazlin Bin KamarudinZeno BisoffiPatrick BistonLaurent BitkerMustapha BittayeJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotFilomena BocciaLaetitia BodenesDebby BogaertAnne-Hélène BoivinIsabela BolañosPierre-Adrien BolzeFrançois BompartAurelius BonfasiusDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKévin BouillerLaurence BouilletCamile BouisseLatsaniphone BountthasavongAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisMarielle Boyer-BesseyreMaria BoylanFernando Augusto BozzaAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziPatrick BreenDorothy BreenDavid BrewsterKathy BrickellTessa BroadleyHelen BrothertonShaunagh BrowneAlex BrowneNicolas BrozziSonja Hjellegjerde BrunvollMarjolein Brusse-KeizerPetra BrydaNina BuchtelePolina BugaevaMarielle BuissonDanilo BuonsensoErlina BurhanIngrid BustosDenis ButnaruAndré CabieSusana CabralJoana CabritaEder CaceresCyril CadozRui Caetano GarcêsKate CalligyJose Andres CalvacheJoão CamõesValentine CampanaPaul CampbellJosie CampisiCecilia CanepaMireia CanteroJanice CaoiliPauline Caraux-PazSheila CárcelSofia CardosoFilipe CardosoFilipa CardosoNelson CardosoSimone CarelliNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoMasaneh CeesayMinerva Cervantes-GonzalezMuge CevikAnissa ChairCatherine ChakveatzeAdrienne ChanMeera ChandJean-Marc ChapplainCharlotte CharpentierJulie ChasJonathan Samuel Chávez IñiguezAnjellica ChenYih-Sharng ChenLéo ChenardMatthew Pellan ChengAntoine CheretThibault ChiarabiniJulian ChicaSuresh Kumar ChidambaramLeong Chin ThoCatherine ChirouzeDavide ChiumelloSung-Min ChoBernard CholleyDanoy ChommanamMarie-Charlotte ChopinTing Soo ChowNathaniel ChristyHiu Jian ChuaJonathan ChuaJose Pedro CidadeJosé Miguel Cisneros HerrerosAnna CiulloJennifer ClarkeRolando Claure-del GranadoSara ClohiseyCassidy CodanCaitriona CodyJennifer ColesGwenhaël ColinMichael CollinsPamela CombsJennifer ConnollyMarie ConnorAnne ConradElaine ConwayGraham CookeHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganCosimo CristellaGloria CrowlJonathan CrumpClaudina CruzJuan Luis Cruz BermúdezJaime Cruz RojoMarc CseteAilbhe CullenMatthew CummingsGerard CurleyElodie CurlierColleen CurranPaula CustodioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensJohn Arne DahlDarren DahlyUmberto d'AlessandroPeter DaleyJo DaltonHeidi DaltonSeamus DalyJuliana DamasNick DanemanEmmanuelle DankwaJorge DantasFrédérick d'AragonMenno de JongGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaCristina de RoseThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardBianca DebenedictisMarie-Pierre DebrayNathalie DecastroWilliam DechertRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneNathalie DelfosIonna DeligiannisAndrea Dell'AmoreChristelle DelmasPierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtMehul DesaiDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangarAlpha DialloSylvain DiamantisAndré DiasFernanda Dias da SilvaJuan Jose DiazRodrigo DiazPriscila DiazBakary DibbaKévin DidierJean-Luc DiehlWim DieperinkJérôme DimetVincent DinotFara DiopAlphonsine DioufYael DishonFélix DjossouAnnemarie DochertyHelen DohertyArjen DondorpChristl DonnellySean DonohueYoann DonohuePeter DoranCéline DorivalEric d'OrtenzioYash DoshiPhouvieng DouangdalaJames Joshua DouglasRenee DoumaNathalie DournonJoanne DowneyMark DowningThomas DrakeAoife DriscollAmiel DrorMurray DrydenClaudio Duarte FonsecaVincent DubeeFrançois DubosAudrey Dubot-PérèsAlexandre DucancelleToni DuculanSusanne DudmanAbhijit DuggalPaul DunandJake DunningMathilde DuplaixEmanuele Durante-MangoniLucian Durham IiiBertrand DussolJuliette DuthoitXavier DuvalAnne Margarita Dyrhol-RiiseSim Choon EanMarco Echeverria-VillalobosMichael EdelsteinSiobhan EganLinn Margrete EggesbøCarla EiraMohammed El SanharawiSubbarao ElapavaluruBrigitte ElharrarJacobien EllerbroekMerete Ellingjord-DaleLoubna ElotmaniPhilippine EloyTarek ElshazlyIqbal ElyazarIsabelle EnderleTomoyuki EndoChan Chee EngIlka EngelmannVincent EnoufOlivier EpaulardMartina EscherMariano EsperattiHélène EsperouCatarina Espírito SantoMarina Esposito-FareseJoão EstevãoManuel EtienneAnna Greti EverdingMirjam EversMarc FabreIsabelle FabreIsmaila FaderaAmna FaheemArabella FahyCameron FairfieldPedro FariaHanan FateenaArie Zainul FatoniKarine FaureRaphaël FavoryMohamed FayedNiamh FeelyJorge FernandesMarília Andreia FernandesSusana FernandesFrançois-Xavier FerrandEglantine Ferrand DevougeJoana FerrãoMário FerrazSílvia FerreiraBernardo FerreiraBenigno FerreiraIsabel FerreiraNicolas FerriereCéline FickoClaudia Figueiredo-MelloWilliam FinlaysonThomas FlamentTom FletcherAline-Marie FlorenceLetizia Lucia FlorioDeirdre FlynnBrigid FlynnJean FoleyVictor FominTatiana FonsecaPatricia FontelaKaren ForrestSimon ForsythDenise FosterGiuseppe FotiErwan FournRobert FowlerMarianne FraherDiego Franch-LlasatJohn FraserChristophe FraserMarcela Vieira FreireAna Freitas RibeiroCaren FriedrichRicardo FritzStéphanie FryNora FuentesMasahiro FukudaArgin GValérie GaborieauRostane GaciMassimo GagliardiJean-Charles GagnardAmandine Gagneux-BrunonAbdou GaiSérgio GaiãoLinda Gail SkeiePhil GallagherCarrol GambleYasmin GaniArthur GaranRebekha GarciaNoelia García BarrioJulia Garcia-DiazEsteban Garcia-GalloNavya GarimellaDenis GarotValérie GarraitAnatoliy GavrylovAlexandre GaymardJohannes GebauerEva GeraudLouis Gerbaud MorlaesNuno GermanoPraveen Kumar GhisulalJade GhosnMarco GianiTristan GiganteElaine GilroyGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanPetr GlybochkoEric GnallGeraldine GocoFrançois GoehringerSiri GoepelJean-Christophe GoffardJin Yi GohJonathan GolobRui GomesKyle GomezJoan Gómez-JunyentMarie GominetAlicia GonzalezPatricia GordonYanay GorelikIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokMargarite GrableJeronimo 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Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSue WillemsBailey WilliamsVirginie WilliamsPatricia WilliamsJessica WittmanCalvin WongXin Ci WongYew Sing WongTeck Fung WongNatalie WrightLim Saio XianIoannis XynogalasSiti Rohani Binti Mohd YakopMasaki YamazakiElizabeth YaradYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichTouxiong YiayeToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : Université de Sherbrooke, Sherbrooke, Quebec, Canada.
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : Importance Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines. Objectives To compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation. Design, Setting, and Participants This prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)–WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set). Exposure Corticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Main Outcomes and Measures Number and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region. Results Among 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3). Conclusions and Relevance The results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2023
• Auteurs : Denise BattagliniNicole WhiteLavienraj PremrajBarbara Wanjiru CitarellaLaura MersonChiara RobbaDavid ThomsonSung-Min ChoLaurent AbelAmal AbrousKamal Abu JabalManuella AdemnouYounes Ait TamlihatAliya Mohammed AlameenMarta AlessiBeatrice AlexKévin AlexandreAdam AliKazali Enagnon AlidjnouClotilde AllavenaNathalie AllouPasquale AnaniaClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartJean-Benoît ArletElise Artaud-MacariGrace AssiJean Baptiste AssieFouda AtanganaJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenJohn Kenneth BaillieFirouzé Bani-SadrWendy BarclayMarie BartoliJoaquín BaruchRomain BasmaciJules BauerAlexandra BedossaHusna BegumSylvie BehilillAnna BeltrameMarine BeluzeNicolas BenechDelphine BergeaudJosé Luis Bernal SobrinoGiulia BertoliSimon BessisSybille BevilcaquaKarine BezulierKrishna BhavsarSandra BichokaZeno BisoffiLaurent BitkerMathieu BlotLucille BlumbergLaetitia BodenesDebby BogaertAnne-Hélène BoivinAriel BolangaIsabela BolañosPierre-Adrien BolzeRaphaël BorieElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDamien BouhourKévin BouillerLaurence BouilletCamile BouisseAnne-Sophie BoureauMaude BouscambertAurore BousquetMarielle Boyer-BesseyreAxelle BraconnierSonja Hjellegjerde BrunvollMarielle BuissonDanilo BuonsensoDonald BuriAidan BurrellIngrid BustosAndré CabieEder CaceresCyril CadozJose Andres CalvacheValentine CampanaPauline Caraux-PazNicolas CarlierThierry CarmoiMarie-Christine CarretGail CarsonMaire-Laure CasanovaGuylaine Castor-AlexandreFrançois-Xavier CatherineMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeMeera ChandJean-Marc ChapplainCharlotte CharpentierJulie ChasLéo ChenardAntoine CheretThibault ChiarabiniCatherine ChirouzeBernard CholleyMarie-Charlotte ChopinYock Ping ChowSara ClohiseyGwenhaël ColinMarie ConnorAnne ConradGraham CookeHugues CordelAndrea CortegianiGrégory CorvaisierCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseJuan Luis Cruz BermúdezJaime Cruz RojoElodie CurlierAna da SilvafilipeCharlene da SilveiraAndrew DagensJohn Arne DahlJo DaltonCammandji DamienEtienne de MontmollinCristina de RoseThushan de SilvaAlexa DebardMarie-Pierre DebrayNathalie DecastroRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneChristelle DelmasPierre DelobelElisa DemonchyEmmanuelle DenisDominique DeplanqueDiane DescampsMathilde DesvalléesAlpha DialloSylvain DiamantisFernanda Dias Da SilvaKévin DidierJean-Luc DiehlJérôme DimetVincent DinotFara DiopAlphonsine DioufCedric DjaddaFélix DjossouAnnemarie DochertyChristl DonnellyCéline DorivalEric D’ortenzioYash DoshiNathalie DournonThomas DrakeAmiel DrorMurray DrydenVincent DubeeFrançois DubosAlexandre DucancelleSusanne DudmanPaul DunandJake DunningBertrand DussolXavier DuvalAnne Margarita Dyrhol-RiiseAda EboMichael EdelsteinLinn Margrete EggesbøMohammed ElsanharawiBrigitte ElharrarMerete Ellingjord-DaleLauren EloundouPhilippine EloyIsabelle EnderleGervais EneliIlka EngelmannVincent EnoufOlivier EpaulardHélène EsperouMarina Esposito-FareseRachel EssakaManuel EtienneMirjam EversMarc FabreIsabelle FabreCameron FairfieldKarine FaureRaphaël FavoryFrançois-Xavier FerrandEglantine Ferrand DevougeNicolas FerriereCéline FickoWilliam FinlaysonThomas FlamentTom FletcherAline-Marie FlorenceBerline FotsoErwan FournRobert FowlerChristophe FraserStéphanie FryValérie GaborieauRostane GaciJean-Charles GagnardAmandine Gagneux-BrunonSérgio GaiãoLinda Gail SkeieCarrol GambleNoelia García BarrioEsteban Garcia-GalloDenis GarotValérie GarraitAnatoliy GavrylovAlexandre GaymardEva GeraudLouis Gerbaud MorlaesJade GhosnTristan GiganteGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanFrançois GoehringerKyle GomezMarie GominetYanay GorelikIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokPascal GranierChristopher GreenWilliam GreenhalfSegolène GreffeFiona GriffithsJérémie GuedjMartin GuegoRomain GueryAnne GuillaumotLaurent GuilleminaultThomas GuimardAli HachemiNadir HadriMatthew HallSophie HalpinRebecca HamidfarBato HammarströmHayley HardwickEwen HarrisonJanet HarrisonLars HeggelundRoss HendryMaxime HentzienDiana HernandezLiv HesstvedtRupert HigginsHaider HirkaniHikombo HitotoAntonia HoAlexandre HoctinIsabelle HoffmannPeter HorbyIkram HouasJean-Sébastien HulotSamreen IjazPatrick ImbertMariachiara IppolitoMargaux IsnardDanielle JaafarSalma JaafouraJulien JabotClare JacksonWaasila JassatStéphane JaureguiberryFlorence JegoSynne JenumCédric JosephMercé JourdainOuifiya KafifFlorentia KaguelidouSabina KaliDeepjyoti KalitaChristiana KartsonakiSeán KeatingPulak KediaSadie KellyKalynn KennonYounes KerroumiAntoine KhalilKrish KherajaniSaye KhooAntoine KimmounEyrun Floerecke Kjetland KjetlandPaul KlenermanStephen KnightStephanie KoubaArsène KpangonOksana KruglovaGalyna KutsynaSylvie KwediMarie LachatreMarie LacosteNadhem LafhejMarie LagrangeFabrice LaineOlivier LairezAntonio LaluezaMarc LambertMarie Langelot-RichardVincent LangloisCédric LaouénanSamira LaribiDelphine LariviereStéphane LasrySakshi LathOdile LaunayDidier LaureillardYoan Lavie-BadieAndy LawMinh LeClément BihanCyril BrisGeorges FalherLucie FevreQuentin HingratMarion MaréchalSoizic MestreGwenaël MoalVincent MoingHervé NagardJames LeeJennifer LeeGary LeemingBénédicte LefebvreLaurent LefebvreBenjamin LefèvreSylvie LegacJean-Daniel LelievreAdrien LemaignenVéronique LemeeAnthony LemeurMarc LeoneQuentin LepillerFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierSophie LetrouBruno LevyYves LevyClaire Levy-MarchalErwan L’herGeoffrey LiegeonBruno LinaAndreas LindGuillaume LingasSylvie Lion-DaolioMarine LivrozetPaul LoubetBouchra LouftiGuillame LouisMiles LunnLiem LuongDominique LutonMoïse MachadoGabriel MachedaRafael MahieuSophie MahyMylène MailletThomas MaitreDenis MalvyVictoria MandaLaurent MandelbrotJulie MankikianAldric ManuelSamuel MarkowiczLaura MarshJohn MarshallGuillaume Martin-BlondelMartin MartinotOlga MartynenkoMoise MassomaPalmer MasumbeMathieu MatteiLaurence MaulinThierry MazzoniColin McarthurSarah McdonaldKenneth McleanCécile Mear-PassardNastia MedombouFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreRoberta MetaAgnès MeybeckAlison MeynertVanina MeysonnierMehdi MezidiCéline MichelangleiIsabelle MicheletShona MooreSarah MooreLucia MoroHugo MouquetJulien MoyetCaroline MudaraJimmy MullaertFredrik MüllerMarlène MurrisSrinivas MurthyAlamin MustafaNadège NeantAnthony NghiDuc NguyenNerissa NibaAlistair NicholMahdad NoursadeghiSaad NseirLeonard NumforElsa NyamankollyPiero OlliaroPierre OndoboWilna OosthuyzenPeter OpenshawPaul OtikuNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesMassimo PalmariniNathalie PansuAurélie PapadopoulosRachael ParkeJérémie PasquierBruno PasteneDrashti PatelChristelle PaulWilliam PaxtonJean-François PayenFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneDaniel PerezThomas PerpointVincent PestreVentzislava Petrov-SanchezGilles PeytavinWalter PicardOlivier PiconeLionel PirothChiara PiubelliRiinu PiusLaurent PlantierJulien PoissyRyadh PokeerbuxGeorgios PollakisDiane PonscarmeSébastien PréauMark PritchardElse Quist-PaulsenChristian RabaudMarie RafiqBlandine RammaertChristophe RappStanislas RebaudetSarah RedlMartine RemyAnne-Sophie ResseguierMatthieu RevestAntonia RicchiutoLaurent RichierPatrick RispalKarine RissoStephanie RobertsDavid RobertsonOlivier RobineauPaola RodariPierre-Marie RogerAmanda RojekMélanie RorizManuel Rosa-CalatravaAndrea RossanesePatrick RossignolCarine RoyBenoît RozeClark RussellNadia SaidaniHélène SalvatorOlivier SanchezVanessa Sancho-ShimizuPierre-François SandrineOana SăndulescuBenjamine SartonAnkana SatyaEgle SaviciuteArnaud ScherpereelMarion SchneiderJanet ScottJames Scott-BrownNicholas SedillotMalcolm SempleEric SennevilleCatherine ShawVictoria ShawRohan ShettyJeanne SibiudeLouise SigfridDario SinattiGirish SindhwaniMahendra SinghVegard SkogenSue SmithTom SolomonAgnès SommetArne SøraasAlbert SottoEdouard SoumElisabetta SpinuzzaShiranee SriskandanSarah StablerTrude SteinsvikBirgitte StiksrudAdrian Streinu-CercelAnca Streinu-CercelDavid StuartRicha SuCharlotte SummersLysa TaghersetRenaud TamisierCoralie TardivonPierre TattevinMarie-Capucine TellierFrançois TéouléOlivier TerrierNicolas TerziVincent ThibaultSimon-Djamel ThibervilleBenoît ThillEmma ThomsonMathew ThorpeRyan ThwaitesVadim TieroshynJean-François TimsitNoémie TissotKristian TonbyCécile TromeurTiffany TrouillonJeanne TruongChristelle TualSarah TubianaJean-Marie TurmelLance TurtleAnders TveitaTimothy UyekiPiero ValentiniSylvie van der WerfNoémie VanelCharline VauchyAurélie VeislingerGayatri VishwanathanBenoit VisseauxFanny VuottoSteve WebbJia WeiMurray WhamPaul Henri WickyAurélie WiedemannNatalie WrightYazdan YazdanpanahCécile YelnikHodane YonisMarion ZabbeMaria ZambonHiba ZayyadDavid Zucma.
• Organismes : IRCCS Ospedale Policlinico San Martino, Genova, Italy
• Publié dans Journal of Neurology le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2023
• Auteurs : Denise BattagliniNicole WhiteLavienraj PremrajBarbara Wanjiru CitarellaLaura MersonChiara RobbaDavid ThomsonSung-Min ChoLaurent AbelAmal AbrousKamal Abu JabalManuella AdemnouYounes Ait TamlihatAliya Mohammed AlameenMarta AlessiBeatrice AlexKévin AlexandreAdam AliKazali Enagnon AlidjnouClotilde AllavenaNathalie AllouPasquale AnaniaClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartJean-Benoît ArletElise Artaud-MacariGrace AssiJean Baptiste AssieFouda AtanganaJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenJohn Kenneth BaillieFirouzé Bani-SadrWendy BarclayMarie BartoliJoaquín BaruchRomain BasmaciJules BauerAlexandra BedossaHusna BegumSylvie BehilillAnna BeltrameMarine BeluzeNicolas BenechDelphine BergeaudJosé Luis Bernal SobrinoGiulia BertoliSimon BessisSybille BevilcaquaKarine BezulierKrishna BhavsarSandra BichokaZeno BisoffiLaurent BitkerMathieu BlotLucille BlumbergLaetitia BodenesDebby BogaertAnne-Hélène BoivinAriel BolangaIsabela BolañosPierre-Adrien BolzeRaphaël BorieElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDamien BouhourKévin BouillerLaurence BouilletCamile BouisseAnne-Sophie BoureauMaude BouscambertAurore BousquetMarielle Boyer-BesseyreAxelle BraconnierSonja Hjellegjerde BrunvollMarielle BuissonDanilo BuonsensoDonald BuriAidan BurrellIngrid BustosAndré CabieEder CaceresCyril CadozJose Andres CalvacheValentine CampanaPauline Caraux-PazNicolas CarlierThierry CarmoiMarie-Christine CarretGail CarsonMaire-Laure CasanovaGuylaine Castor-AlexandreFrançois-Xavier CatherineMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeMeera ChandJean-Marc ChapplainCharlotte CharpentierJulie ChasLéo ChenardAntoine CheretThibault ChiarabiniCatherine ChirouzeBernard CholleyMarie-Charlotte ChopinYock Ping ChowSara ClohiseyGwenhaël ColinMarie ConnorAnne ConradGraham CookeHugues CordelAndrea CortegianiGrégory CorvaisierCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseJuan Luis Cruz BermúdezJaime Cruz RojoElodie CurlierAna da SilvafilipeCharlene da SilveiraAndrew DagensJohn Arne DahlJo DaltonCammandji DamienEtienne de MontmollinCristina de RoseThushan de SilvaAlexa DebardMarie-Pierre DebrayNathalie DecastroRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneChristelle DelmasPierre DelobelElisa DemonchyEmmanuelle DenisDominique DeplanqueDiane DescampsMathilde DesvalléesAlpha DialloSylvain DiamantisFernanda Dias Da SilvaKévin DidierJean-Luc DiehlJérôme DimetVincent DinotFara DiopAlphonsine DioufCedric DjaddaFélix DjossouAnnemarie DochertyChristl DonnellyCéline DorivalEric D’ortenzioYash DoshiNathalie DournonThomas DrakeAmiel DrorMurray DrydenVincent DubeeFrançois DubosAlexandre DucancelleSusanne DudmanPaul DunandJake DunningBertrand DussolXavier DuvalAnne Margarita Dyrhol-RiiseAda EboMichael EdelsteinLinn Margrete EggesbøMohammed ElsanharawiBrigitte ElharrarMerete Ellingjord-DaleLauren EloundouPhilippine EloyIsabelle EnderleGervais EneliIlka EngelmannVincent EnoufOlivier EpaulardHélène EsperouMarina Esposito-FareseRachel EssakaManuel EtienneMirjam EversMarc FabreIsabelle FabreCameron FairfieldKarine FaureRaphaël FavoryFrançois-Xavier FerrandEglantine Ferrand DevougeNicolas FerriereCéline FickoWilliam FinlaysonThomas FlamentTom FletcherAline-Marie FlorenceBerline FotsoErwan FournRobert FowlerChristophe FraserStéphanie FryValérie GaborieauRostane GaciJean-Charles GagnardAmandine Gagneux-BrunonSérgio GaiãoLinda Gail SkeieCarrol GambleNoelia García BarrioEsteban Garcia-GalloDenis GarotValérie GarraitAnatoliy GavrylovAlexandre GaymardEva GeraudLouis Gerbaud MorlaesJade GhosnTristan GiganteGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanFrançois GoehringerKyle GomezMarie GominetYanay GorelikIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokPascal GranierChristopher GreenWilliam GreenhalfSegolène GreffeFiona GriffithsJérémie GuedjMartin GuegoRomain GueryAnne GuillaumotLaurent GuilleminaultThomas GuimardAli HachemiNadir HadriMatthew HallSophie HalpinRebecca HamidfarBato HammarströmHayley HardwickEwen HarrisonJanet HarrisonLars HeggelundRoss HendryMaxime HentzienDiana HernandezLiv HesstvedtRupert HigginsHaider HirkaniHikombo HitotoAntonia HoAlexandre HoctinIsabelle HoffmannPeter HorbyIkram HouasJean-Sébastien HulotSamreen IjazPatrick ImbertMariachiara IppolitoMargaux IsnardDanielle JaafarSalma JaafouraJulien JabotClare JacksonWaasila JassatStéphane JaureguiberryFlorence JegoSynne JenumCédric JosephMercé JourdainOuifiya KafifFlorentia KaguelidouSabina KaliDeepjyoti KalitaChristiana KartsonakiSeán KeatingPulak KediaSadie KellyKalynn KennonYounes KerroumiAntoine KhalilKrish KherajaniSaye KhooAntoine KimmounEyrun Floerecke Kjetland KjetlandPaul KlenermanStephen KnightStephanie KoubaArsène KpangonOksana KruglovaGalyna KutsynaSylvie KwediMarie LachatreMarie LacosteNadhem LafhejMarie LagrangeFabrice LaineOlivier LairezAntonio LaluezaMarc LambertMarie Langelot-RichardVincent LangloisCédric LaouénanSamira LaribiDelphine LariviereStéphane LasrySakshi LathOdile LaunayDidier LaureillardYoan Lavie-BadieAndy LawMinh LeClément BihanCyril BrisGeorges FalherLucie FevreQuentin HingratMarion MaréchalSoizic MestreGwenaël MoalVincent MoingHervé NagardJames LeeJennifer LeeGary LeemingBénédicte LefebvreLaurent LefebvreBenjamin LefèvreSylvie LegacJean-Daniel LelievreAdrien LemaignenVéronique LemeeAnthony LemeurMarc LeoneQuentin LepillerFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierSophie LetrouBruno LevyYves LevyClaire Levy-MarchalErwan L’herGeoffrey LiegeonBruno LinaAndreas LindGuillaume LingasSylvie Lion-DaolioMarine LivrozetPaul LoubetBouchra LouftiGuillame LouisMiles LunnLiem LuongDominique LutonMoïse MachadoGabriel MachedaRafael MahieuSophie MahyMylène MailletThomas MaitreDenis MalvyVictoria MandaLaurent MandelbrotJulie MankikianAldric ManuelSamuel MarkowiczLaura MarshJohn MarshallGuillaume Martin-BlondelMartin MartinotOlga MartynenkoMoise MassomaPalmer MasumbeMathieu MatteiLaurence MaulinThierry MazzoniColin McarthurSarah McdonaldKenneth McleanCécile Mear-PassardNastia MedombouFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreRoberta MetaAgnès MeybeckAlison MeynertVanina MeysonnierMehdi MezidiCéline MichelangleiIsabelle MicheletShona MooreSarah MooreLucia MoroHugo MouquetJulien MoyetCaroline MudaraJimmy MullaertFredrik MüllerMarlène MurrisSrinivas MurthyAlamin MustafaNadège NeantAnthony NghiDuc NguyenNerissa NibaAlistair NicholMahdad NoursadeghiSaad NseirLeonard NumforElsa NyamankollyPiero OlliaroPierre OndoboWilna OosthuyzenPeter OpenshawPaul OtikuNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesMassimo PalmariniNathalie PansuAurélie PapadopoulosRachael ParkeJérémie PasquierBruno PasteneDrashti PatelChristelle PaulWilliam PaxtonJean-François PayenFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneDaniel PerezThomas PerpointVincent PestreVentzislava Petrov-SanchezGilles PeytavinWalter PicardOlivier PiconeLionel PirothChiara PiubelliRiinu PiusLaurent PlantierJulien PoissyRyadh PokeerbuxGeorgios PollakisDiane PonscarmeSébastien PréauMark PritchardElse Quist-PaulsenChristian RabaudMarie RafiqBlandine RammaertChristophe RappStanislas RebaudetSarah RedlMartine RemyAnne-Sophie ResseguierMatthieu RevestAntonia RicchiutoLaurent RichierPatrick RispalKarine RissoStephanie RobertsDavid RobertsonOlivier RobineauPaola RodariPierre-Marie RogerAmanda RojekMélanie RorizManuel Rosa-CalatravaAndrea RossanesePatrick RossignolCarine RoyBenoît RozeClark RussellNadia SaidaniHélène SalvatorOlivier SanchezVanessa Sancho-ShimizuPierre-François SandrineOana SăndulescuBenjamine SartonAnkana SatyaEgle SaviciuteArnaud ScherpereelMarion SchneiderJanet ScottJames Scott-BrownNicholas SedillotMalcolm SempleEric SennevilleCatherine ShawVictoria ShawRohan ShettyJeanne SibiudeLouise SigfridDario SinattiGirish SindhwaniMahendra SinghVegard SkogenSue SmithTom SolomonAgnès SommetArne SøraasAlbert SottoEdouard SoumElisabetta SpinuzzaShiranee SriskandanSarah StablerTrude SteinsvikBirgitte StiksrudAdrian Streinu-CercelAnca Streinu-CercelDavid StuartRicha SuCharlotte SummersLysa TaghersetRenaud TamisierCoralie TardivonPierre TattevinMarie-Capucine TellierFrançois TéouléOlivier TerrierNicolas TerziVincent ThibaultSimon-Djamel ThibervilleBenoît ThillEmma ThomsonMathew ThorpeRyan ThwaitesVadim TieroshynJean-François TimsitNoémie TissotKristian TonbyCécile TromeurTiffany TrouillonJeanne TruongChristelle TualSarah TubianaJean-Marie TurmelLance TurtleAnders TveitaTimothy UyekiPiero ValentiniSylvie van der WerfNoémie VanelCharline VauchyAurélie VeislingerGayatri VishwanathanBenoit VisseauxFanny VuottoSteve WebbJia WeiMurray WhamPaul Henri WickyAurélie WiedemannNatalie WrightYazdan YazdanpanahCécile YelnikHodane YonisMarion ZabbeMaria ZambonHiba ZayyadDavid Zucma.
• Organismes : Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans Journal of Neurology le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Kristina LygnerudTheo NybergAnna NilssonAntoine FabrePascal StabatChloé DuchayneValentin Gavan
• Organismes : Swedish Environmental Research Institute Lund University Swedish Environmental Research Institute Swedish Environmental Research Institute Centre Efficacité Énergétique des Systèmes Centre Efficacité Énergétique des Systèmes ENGIE ENGIE
• Publié dans Energy, Sustainability and Society le 19/11/2018

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Résumé : Abstract Background District Heating (DH) is a technology that provides heating and domestic hot water to buildings and is an important technology for supporting the European energy transition. As such the heating systems increasingly resort to renewable heat sources and waste heat, it is even more important that they operate in the most efficient way possible. DH companies have access to the primary network of which they can impact system performance. To maximize the efficiency of the system, however, it is important that the system at the building level, known as the secondary system, is also efficient; otherwise, overall system efficiency is reduced. To increase system efficiency, return temperatures from the secondary system into the primary system have been targeted through motivational tariffs. There is limited information on how to establish a motivational tariff that motivates the customer to improve both the primary and secondary systems, which is a gap that this paper aims to fill. Results In this paper, the impacts of retrofit actions in secondary systems are assessed through simulations. The identified relevant refurbishment measures to lower the return temperature to the primary system are variable flow pumps, low-temperature radiators, parallel heat exchangers, and a pass-through DHW system. Apart from simulated refurbishments, we also identify that the secondary system sometimes generates excess heat, which is valuable to recover, especially during peak load periods for the primary system. Hence, motivational tariffs targeting secondary system efficiency should also encompass an incentive for the customer to make use of waste heat in the secondary circuit to lower peak demand for the DH system. Conclusions To date, the most commonly used parameters introduced to customers are linked to the flow of water through the customer’s asset and the bonus malus principle. The results from simulations show that DH companies can introduce additional parameters to support customers in guiding their secondary system to perform more efficiently. Increased overall system efficiency has a positive impact on both costs and emissions.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/11/2023
• Auteurs : Frédéric FabreMéline SaubinJérôme CovilleConstance XhaardPascal FreySamuel SoubeyrandFabien Halkett
• Organismes : Santé et agroécologie du vignoble Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes Biostatistique et Processus Spatiaux Interactions Arbres-Microorganismes

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Résumé : Dispersal, and in particular the frequency of long-distance dispersal (LDD) events, has strong implications for population dynamics with possibly the acceleration of the colonisation front, and for evolution with possibly the conservation of genetic diversity along the colonised domain. However, accurately inferring LDD is challenging as it requires both large-scale data and a methodology that encompasses the redistribution of individuals in time and space. Here, we propose a mechanistic-statistical framework to estimate dispersal from one-dimensional invasions. The mechanistic model takes into account population growth and grasps the diversity in dispersal processes by using either diffusion, leading to a reaction-diffusion (R.D.) formalism, or kernels, leading to an integro-differential (I.D.) formalism. The latter considers different dispersal kernels (e.g. Gaussian, Exponential, and Exponential-power) differing in their frequency of LDD events. The statistical model relies on dedicated observation laws that describe two types of samples, clumped or not. As such, we take into account the variability in both habitat suitability and occupancy perception. We first check the identifiability of the parameters and the confidence in the selection of the dispersal process. We observed good identifiability for all parameters (correlation coefficient > 0.9 between true and fitted values). The dispersal process that is the most confidently identified is Exponential-Power (i.e. fat-tailed) kernel. We then applied our framework to data describing an annual invasion of the poplar rust disease along the Durance River valley over nearly 200 km. This spatio-temporal survey consisted of 12 study sites examined at seven time points. We confidently estimated that the dispersal of poplar rust is best described by an Exponential-power kernel with a mean dispersal distance of 1.94 km and an exponent parameter of 0.24 characterising a fat-tailed kernel with frequent LDD events. By considering the whole range of possible dispersal processes our method forms a robust inference framework. It can be employed for a variety of organisms, provided they are monitored in time and space along a one-dimension invasion.

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Fichiers liés : Program_EDySA-MOMA_2023.pdf

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