Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Ryma BenrabahÉmilien GirotJean-Marc CommengeRené FournetPhilippe ArnouxPierre-Alexandre GlaudeBaptiste Sirjean
• Organismes : Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Département de Chimie Physique des Réactions Laboratoire Réactions et Génie des Procédés
• Publié dans Chemical Engineering Science le 29/10/2020

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Résumé : Liquid phase oxidation reactions are widely studied and optimized for industrial processes of interest such as the oxidation of cyclohexane. The slow oxidation of hydrocarbons, which takes place throughout their chain of use, is the cause of fuel deterioration known as fuel ageing. In recent years, the use of microfluidic tools for the investigation of such processes is expanding with the development of the technologies. Microfluidics enables the use of explosive conditions in a safer way than traditional processes and these tools can be adapted for the kinetic study of the oxidation of ground fuels and jet fuels. Their kinetics of oxidation are slow, and their study requires long residence times, which are not usually reached in the microfluidic field. The PEEK-ACHU rig, a microfluidic device with a heated silicon/glass microfluidic reactor designed for long residence times (from 16 min up to 230 min) and high pressure (up to 40 bar), was developed for the study of slow oxidation reactions of organic compounds. This work presents the design of the reactor and proposes a hydrodynamic study of the gas-liquid Taylor flow implemented in this tool to enable the study of oxidation reactions of fuels. A good understanding of the different diphasic flow regimes as a function of gas bubble generation was obtained for conditions in the explosive range. A correlation was found between the density and viscosity of a fuel and the length of gas bubbles and liquid slugs. The thickness of the residual liquid film at the wall and the reaction regime were characterized and demonstrate that the design of our microreactor enables the kinetic study of organic compounds oxidation, without oxygen mass transfer limitations, at high temperature and high pressure, for very long residence times.

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Fichiers liés : microfluidic_article_R1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/12/2025
• Auteurs : Jose Villasboas BisnetoStephen SmithDanielle WallaceJean-Pierre MarolleauCarlos Grande GarciaReid MerrymanFrancesc BoschLuca ArcainiAntonio PintoNorma GutierrezBrian TillPierre MorelRocío Figueroa MoraCristina GarcíaSara RattottiLucie AubergeonLaurent ChêneJan FagerbergPier Luigi ZinzaniPhilippe ArmandJonathan FriedbergStephen Ansell
• Organismes : Mayo Clinic [Rochester] Fred Hutchinson Cancer Research Center [Seattle] Wilmot Cancer Institute [Rochester] Service d'Hématologie Clinique et Thérapie Cellulaire [CHU Amiens] HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Universidad de Navarra [Pamplona] Dana-Farber Cancer Institute [Boston] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples, Italy] Instituto de Investigación Biomédica de Salamanca Service de radiothérapie [CHU Amiens] Universidad de Navarra [Pamplona] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Alma Mater Studiorum Università di Bologna = University of Bologna Dana-Farber Cancer Institute [Boston] University of Rochester [USA] Mayo Clinic [Rochester]

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Résumé : Background Follicular lymphoma (FL) is a generally indolent disease where a watch and wait strategy is standard in asymptomatic patients (pts) with a low tumor-burden. Harnessing antitumor immunity through an anti-tumor immunization strategy at this stage may delay or avoid the subsequent need for more toxic and complex therapies. EO2463 is a therapeutic vaccine designed from non-self protein sequences, derived from gut bacteria, including 4 HLA-A2 synthetically produced 9-mer CD8 cytotoxic T cell epitopes, exhibiting molecular mimicry with specific epitopes on the B cell markers CD20, CD22, CD37, and CD268 (BAFF-receptor). Additionally, EO2463 contains a CD4 helper epitope UCP2 derived from hTERT. The compound expands pre-existing memory CD8 T cells recognizing the non-self protein sequences from gut bacteria which can then cross-react with the selected B cell antigens on tumor cells. EO2463 is being used to drive anti-tumor immunity against B cell malignancies, and has demonstrated long-lasting, specific CD8-memory T cell responses and clinical activity in relapsed/refractory FL and marginal zone lymphoma (MZL) [J Clinical Oncol 2024, 42 (S16), 7058]. Furthermore, CD8 T cells expanded from samples of patients treated with EO2463 can kill HLA-A2 expressing lymphoblastoid cell lines presenting the B cell targets [Hematological Oncol 2023, 41 (S2), 581-582]. Methods The current report describes Cohort 2 of trial EONHL1-20/SIDNEY (NCT04669171) and includes pts with newly diagnosed, previously untreated FL, grade 1-3A, HLA-A2, and not in need of treatment. Pts receive EO2463 (300μg/peptide) SC with adjuvant Montanide ISA 51 VG, q2 weeks (w) x 4, then q4w, for a total of 12 doses (39w; PET-CTs at w6, w19, and w42). Planned accrual for this cohort is 25 pts. Immune responses were assayed on thawed pt peripheral blood mononuclear cells by flow cytometry and EO2463 peptide specific tetramers or by IFN-γ ELISPOT (assaying responses against 9-mer peptides from CD20, CD22, CD37, and CD268; and from peptides of EO2463) without any proceeding in vitro stimulation (ex vivo). Results As of June 2024, 15 pts had started study treatment. Median age was 62 (range 55-66) year, 7 male and 6 female, 2 pts Ann Arbor stage I/II, 5 stage III, and 8 stage IV. Ten of 15 pts were still on treatment; median treatment duration was 18.4 weeks (range 5-39 w) for all pts. Among 13 evaluable pts, best responses by PET-CT using Lugano criteria were 1 pt CR, 5 pts PR (46% objective responses (OR)), 3 pts SD, and 4 pts PD. Of those with PD per Lugano, 2 had isolated increases in FDG-uptake without increase in lesion size/number at w6 and both remain on treatment (per protocol based on LYRIC criteria). OR was first noted w6 in 3 pts and w19 in 3 pts; duration of response is not evaluable at this time due to short follow-up. The pt with CR had isolated increases in FDG-uptake at w6, PR at w19, and CR at w35. Anti-EO2463 immune responses were observed in 4 of 5 tested pts at the 1st testing timepoint (w5) and onwards (currently longest tested up until w31). In an exploratory analysis, the percentage of EO2463 peptide specific CD8 T cells measured by tetramers seemed linked to clinical response (OR 3 pts vs non-OR 2 pts; 2-sided T-test, p=0.02; range of percentages in pts with OR 0.85%-1.39% of all CD8 T cells in peripheral blood, range in pts with non-OR 0.17%-0.27%). Functionality and cross-reactivity of responses were shown by IFN-γ ELISPOT using 9-mer peptides corresponding to the B cell targets in 4 tested pts. Expanded antigen-specific CD8 T cells displayed a memory phenotype; effector/memory (TEM), and terminally differentiated effector memory CD8 T cells (TEMRA). The most common related AEs were grade 1 (7 pts) and grade 2 (5 pts) local administration site reactions (mainly erythema, pruritus, and induration). Other related AEs in > 1 pt were grade 1 headache (2 pts) and grade 1-3 fatigue/asthenia (3 pts). Asthenia lasting 2 days was the only related grade 3 adverse event (AE). Conclusions EO2463 monotherapy is associated with a very manageable safety profile and appears to demonstrate meaningful single-agent efficacy in FL. Consistent with the preclinical hypothesis, expansion of specific CD8 memory T cells may be associated with response. Results will be expanded at the meeting. Study EONHL1-20/SIDNEY also includes cohorts, not covered in this abstract, exploring EO2463 plus rituximab for 1st line FL/MZL, and EO2463 plus lenalidomide/rituximab in relapsed FL/MZL.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2025
• Auteurs : Amélie CrépetPhilippe QuénelJeanne GarricAlain KaufmannJean-Marc BonmatinP DuchéAurélie Mathieu-HuartMadeline CarsiqueJulien JeanPascal SandersJean-Pierre CravediMatthieu SchulerRobert Barouki
• Organismes : Direction de l'Evaluation des Risques École des Hautes Études en Santé Publique [EHESP] Institut de recherche en santé, environnement et travail Université de Rennes Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Université de Lausanne = University of Lausanne Centre de biophysique moléculaire Jeunesse - Activité Physique et Sportive, Santé Direction de l'Evaluation des Risques Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Direction de l'Evaluation des Risques Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Direction de l'Evaluation des Risques Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence pour la Recherche et l’Information en Fruits et Légumes Direction de l'Evaluation des Risques Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire
• Publié dans Environmental Research le 24/10/2020

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Résumé : The exposome is a concept that aims to study the environmental factors to which individuals are exposed during their lifetime and the role of these factors in the development of chronic diseases. Since the concept emerged in 2005, new data, methods, and tools have been generated by the scientific community to assess the different components of the exposome and their impacts on human health. Currently, one of the main challenges is accounting for the diversity and complexity of exposures and their effects on health in risk assessment, which might be accomplished by integrating the exposome into this process. To this end, a working group was constituted by Anses to develop a strategy to integrate the exposome concept in risk assessment and more generally in the work produced by health safety agencies. We present the principal challenges to be addressed by considering 8 themes covering relevant aspects of the exposome and we made recommendations for each theme: 1) characterization of the exposome in epidemiological surveys; 2) exposome data; 3) risk assessment of chemical mixtures; 4) aggregation of multiple sources and routes of exposure; 5) dynamics of the exposure in the context of time, space, and social factors; 6) establishment of reference values; 7) multiple factors in risk, benefit and health impact assessment; and 8) eco-exposome. Then, we propose practical recommendations with short-, medium-, and longterm time scales to progressively operationalize the exposome into risk assessments implemented by health safety agencies. We also discuss how providing broader exposome input into risk assessment can support risk regulators to incorporate exposome input into risk management.

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Fichiers liés : Crepet et al 2025 Exposome 1-s2.0-S0013935125022893-main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/11/2025
• Auteurs : Julien RouzotMickaël PereiraChristian ArtiguesRomain BoyerFrédéric CampsPhilippe GarnierEmmanuel HebrardPierre Lopez
• Organismes : Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Énergie et Systèmes Embarqués Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Laboratoire d'analyse et d'architecture des systèmes Service Informatique : Développement, Exploitation et Assistance Service Informatique : Développement, Exploitation et Assistance Institut de recherche en astrophysique et planétologie Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes

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Résumé : Effective scheduling of tasks for nanosatellites is essential, given their limited onboard resources and capabilities. In a typical nanosatellite mission, the onboard computer has to run payload tasks linked to the mission objective, such as observations and measurements for science campaigns, but also communication and avionic tasks needed for navigation and safety. We consider a partitioned real-time system where a partition is a job that embeds a set of elementary tasks implementing one of the above-described functions. The offline nanosatellite partition scheduling problem consists in scheduling a set of partitions on a single core processor within a fixed time frame that will be repeated cyclically, while maximizing the number and duration of scheduled payload partitions. The paper first establishes similarities and differences with related scheduling problems. We then prove that the problem is strongly NP-hard. A Mixed Integer Linear Programming (MILP) matheuristic and a Constraint Programming (CP) model are proposed. We compare the MILP and CP approaches in a multi-objective context and demonstrate the relevance of the latter to solve the problem efficiently both on randomly generated instances and on a real nanosatellite case study of the University Space Center of Toulouse: the NIMPH project. The CP model is embedded in NanoSatScheduler, an open source software with a user interface designed for the offline nanosatellite partition scheduling problem. For the NIMPH real-case study, the proposed solution outperforms the semi-manual approach used so far. As a result, the NIMPH team has adopted NanoSatScheduler as an operational tool for their mission.

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Fichiers liés : ONPSP.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Jérôme RoncalliFrançois RoubilleYves CottinLionel LerouxAnthony MathurJohn IrvingSohail Q KhanNicolas MeneveauDidier BressonThomas HovasseGiulio PompilioAnthony MattaPhilippe HenonGuillaume TrebuchetMatthieu de KalbermattenIbon GaritaonandiaEric SalouxAlain ManriqueNicolas MeyerPierre-Yves MarieDeepak BhattScott D SolomonGilles MontalescotDavid E NewbyFaiez Zannad
• Organismes : Service Cardiologie [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Module Biothérapies CHU Montpellier = Montpellier University Hospital Service de Cardiologie [CHU de Dijon] Département de cardiologie Barts Heart Centre [London, UK] Barts Health NHS Trust [London, UK] Ninewells Hospital and Medical School [Dundee] Queen Elizabeth Hospital University Hospitals Birmingham [Birmingham, Royaume-Uni] NHS Foundation Trust [London] Hôpital Jean Minjoz [Besançon] Centre Hospitalier Emile Muller [Mulhouse] Institut Cardiovasculaire Paris Sud Centro Cardiologico Monzino [Milano] Università degli Studi di Milano = University of Milan Service Cardiologie [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Module Biothérapies CellProthera CellProthera CellProthera CellProthera Service de cardiologie et de pathologie vasculaire [CHU Caen] Service de médecine nucléaire [CHU Caen] Groupe Méthodes en Recherche Clinique [Strasbourg] Défaillance Cardiovasculaire Aiguë et Chronique Service de Médecine Nucléaire [CHRU Nancy] Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire Mount Sinai Fuster Heart Hospital Icahn School of Medicine at Mount Sinai [New York] Brigham and Women's Hospital [Boston] Harvard Medical School [Boston] CHU Pitié-Salpêtrière [AP-HP] Groupe Action British Heart Foundation Centre of Research Excellence The University of Edinburgh Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris]
• Publié dans JACC: Heart Failure le 29/10/2020

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Fichiers liés : 1-s2.0-S2213177925005542-main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 22/10/2025
• Auteurs : Bruno da Silva HenriquesBenjamin AllaertNicolas Sutton-CharaniPierre SlangenJean-Philippe Vandeborre
• Organismes : Centre for Digital Systems Ecole nationale supérieure Mines-Télécom Lille Douai Centre for Digital Systems Ecole nationale supérieure Mines-Télécom Lille Douai IMT - MINES ALES EuroMov - Digital Health in Motion Centre for Digital Systems Ecole nationale supérieure Mines-Télécom Lille Douai

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Résumé : Accurate egocentric body-pose estimation is essential for delivering immersive experiences in Virtual, Augmented, and Mixed Reality (VR/AR/MR) applications. A major challenge in this setting arises from the limited field of view provided by head-mounted cameras, which often leads to self-occlusion and poor visibility of certain body joints—particularly in the lower body. Current state-of-the-art methods typically perform pose estimation frame-by-frame in a view-aligned manner. While this is computationally efficient and performs well for visible joints, it struggles to estimate occluded joints due to the lack of contextual information. In this work, we explore the role of temporal information in improving joint estimation. We propose a lightweight model that refines pose predictions by leveraging a large temporal window. Our results show that incorporating such module improves the accuracy of joint estimation without incurring a large computation overhead.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 16/10/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanJochen SchieckRobert SchöfbeckMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselDiego Matos FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesLuigi CalligarisFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerZhipeng CuiBolin LiHui WangKai YiJingqing ZhangZhenyu ChenYuji LiJiateng PengYilin ZhouZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouSotiroulla KonstantinouChristos LeonidouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinYasser AssranBasma El-MahdyAhmed HusseinHemida MohammedMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniErik BrückenAnna MilievaKenneth OsterbergMikko VoutilainenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas Samuli KallonenRavindra Kumar VermaTapio LampénKati Lassila-PeriniBettina LehtelaSami LehtiTomas LindénNestor Raul Mancilla XintoMikael MyllymäkiMilla-Maarit RantanenSanteri SaariokariNico Timothy ToikkaJorma TuominiemiNurfikri Bin NorjoharuddeenHenning KirschenmannPanja-Riina LuukkaHenri PetrowMarc BesanconFabrice CoudercMarc DejardinDaniel DenegriPaul DevougeJean-Louis FaureFederico FerriPaul GaigneSerguei GanjourPhilippe GrasGautier Hamel de MonchenaultMintu KumarVictor LohezicYuliia MaidannykJulie MalclesFrancesco OrlandiLouis PortalesSamuele RonchiMehmet Özgür SahinAurore Savoy-NavarroPolina SimkinaMaksym TitovMarta TornagoRuth Amella RanzFlorian BeaudetteGiacomo BoldriniPhilippe BussonClaude CharlotMarco ChiusiTheo Damien CuissetOlivier DavignonAdinda de WitTrisha DebnathIsaac Telford EhleShamik GhoshAndrew GilbertRaphael Granier de CassagnacLida KalipolitiMartina ManoniMatthew NguyenStepan ObraztsovChristophe OchandoRoberto SalernoJean-Baptiste SauvanYves SiroisGamze SokmenLourdes Urda GómezAlexandre ZabiAmina ZghicheJean-Laurent AgramJeremy AndreaDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardGael CoulonSaskia FalkeUlrich GoerlachRaphael HaeberleAnne-Catherine Le BihanMeena MeenaOceane PoncetGourab SahaPaul VaucelleAdriano Di FlorioDavid AmramStephanie BeauceronBenjamin BlanconGaelle BoudoulNicolas ChanonDidier ContardoPierre DepasseHoumani El MamouniJean FaySusan GasconMaxime GouzevitchChristopher GreenbergGérald GrenierBernard IlleElise Jourd'HuyMorgan LethuillierBenjamin MassoteauLaurent MirabitoArnab PurohitMuriel Vander DoncktJie XiaoGeorge AdamovIrakli LomidzeZviad TsamalaidzeValeria BottaSandra Consuegra RodríguezLutz FeldKatja KleinMartin LipinskiPhilipp NattlandVanessa OppenländerAlexander PaulsDanyer Pérez AdánNicolas RöwertCaio DaumannSvenja DiekmannNiclas EichDmitry EliseevFrederic EngelkeJohannes ErdmannMartin ErdmannBenjamin FischerThomas HebbekerKerstin HoepfnerFrancesco IvoneAlexander JungNitish KumarMing-Yan LeeFlorian MausolfMarkus MerschmeyerArnd MeyerAndrey PozdnyakovWahid RedjebHans ReithlerUttiya SarkarValentina SarkisoviAlexander SchmidtChinmay SethArchana SharmaJan Lukas SpahValentyn VaulinShawn ZaleskiMax Romain BeckersChristian DziwokGünter FlüggeNina HoeflichThomas KressAndreas NowackOliver PoothAchim StahlAlexander ZotzAenne AbelMaria Aldaya MartinJuliette AlimenaSimone AmorosoYing AnIakov AndreevJorn BachSamuel BaxterMaryam BayatmakouHugo Becerril GonzalezOlaf BehnkeAlberto BelvedereFreya BlekmanKerstin BorrasAlan CampbellSuman ChatterjeeLucia Ximena Coll SaraviaGuenter EckerlinDoris EcksteinElisabetta GalloAchim GeiserMoritz GuthoffAndreas HinzmannLaurids JeppeMatthias KasemannClaus KleinwortRoman KoglerMatthias KommDirk KrückerWolfgang LangeDaina Leyva PerniaKuan-Yu LinKaterina LipkaWolfgang LohmannJacopo MalvasoRainer MankelIsabell-Alissandra Melzer-PellmannMikel Mendizabal MorentinAndreas Bernhard MeyerGabriele MilellaKeila Moral FigueroaAndreas MussgillerLakshmi Priya NairJeremi NiedzielaAndreas NürnbergJiwon ParkEvan RankenAlexei RasperezaDaniil RastorguevLovisa RygaardMoritz SchamSimon SchnakePaul SchützeChristian SchwanenbergerDennis SchwarzDaria SelivanovaKonstantin SharkoMykyta ShchedrolosievDominic StaffordMatin TorkianAna Ventura BarrosoRoberval WalshDi WangQun WangKatarzyna WichmannLucas WiensChristoph WissingYewon YangStepan ZakharovAndré Zimermmane Castro SantosAna Rita Alves AndradeMassimiliano AntonelloSven BollwegMatteo BonanomiLukas EbelingKarim El MorabitYannick FischerMathis FrahmErika GaruttiAlexander GrohsjeanAyse Asu GuvenliJohannes HallerDaniel HundhausenGregor KasieczkaPhilip KeicherRobert KlannerWilliam KorcariTobias KramerChin-Chia KuoFinn LabeJohannes LangeArtur LobanovJohanna MatthiesenLouis MoureauxKonstantinos NikolopoulosAlexander PaaschKarla Josefina Pena RodriguezNathan ProuvostBianca RacitiMarcel RiegerDaniel SavoiuPeter SchleperMatthias SchröderJoern SchwandtManuel SommerhalderHartmut StadieGeorg SteinbrückRobert WardBogdan WiederspanMoritz WolfChitrakshee YedeSebastian BrommerAlessandro BrusamolinoErik ButzYi-Mu ChenThorsten ChwalekAlexander DierlammGizem Gul DincerDmitry DruzhkinUmut ElicabukNils FaltermannManuel GiffelsArtur GottmannFrank HartmannMaximilian HorzelaFabian HummerUlrich HusemannJan KieselerMarkus KluteJoscha KnolleRufa Kunnilan Muhammed RafeekOlha LavorykJay Mathew LawhornAdelina LintuluotoStefan MaierArtur MonschMichele MormileThomas MüllerEmanuel PfefferMatteo PresillaGunter QuastKlaus RabbertzBrendan RegneryRalf SchmiederNikita ShadskiyIvan ShvetsovHans-Jürgen SimonisLars SowaLea StockmeierKomal TauqeerMaria TomsBogdan TopkoNicolò TrevisaniCedric VerstegeTim VoigtländerRalf Florian von CubeJost von den DrieschMichael WassmerChristian WinterRoger WolfWolfram Dietrich ZeunerXunwu ZuoGeorgios AnagnostouGeorgios DaskalakisAristotelis KyriakisGeorgios MelachroinosZacharias PainesisIoannis ParaskevasNiki SaoulidouKonstantinos TheofilatosEirini 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Résumé : The long-range collective flow of particles produced in oxygen-oxygen (OO) and neon-neon (NeNe) collisions is measured with the CMS detector at the CERN LHC. The data samples were collected at a center-of-mass energy per nucleon pair of 5.36 TeV, with integrated luminosities of 7 nb$^{-1}$ and 0.8 nb$^{-1}$ for OO and NeNe collisions, respectively. Two- and four-particle azimuthal correlations are measured over nearly five units of pseudorapidity. Significant elliptic ($v_2$) and triangular ($v_3$) flow harmonics are observed in both systems. The ratios of $v_n$ coefficients between NeNe and OO collisions reveal sensitivity to quadrupole correlations in the nuclear wave functions. Hydrodynamic models with $\textit{ab initio}$ nuclear structure inputs qualitatively reproduce the collision-overlap dependence of both the $v_n$ values and the NeNe to OO ratios. These measurements provide new constraints on hydrodynamic models for small collision systems and offer valuable input on the nuclear structure of $^{16}$O and $^{20}$Ne.

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 16/10/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de 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Résumé : A novel anomaly detection algorithm is presented. The Wasserstein normalized autoencoder (WNAE) is a normalized probabilistic model that minimizes the Wasserstein distance between the learned probability distribution -- a Boltzmann distribution where the energy is the reconstruction error of the autoencoder -- and the distribution of the training data. This algorithm has been developed and applied to the identification of semivisible jets -- conical sprays of visible standard model particles and invisible dark matter states -- with the CMS experiment at the CERN LHC. Trained on jets of particles from simulated standard model processes, the WNAE is shown to learn the probability distribution of the input data in a fully unsupervised fashion, such that it effectively identifies new physics jets as anomalies. The model consistently demonstrates stable, convergent training and achieves strong classification performance across a wide range of signals, improving upon standard normalized autoencoders, while remaining agnostic to the signal. The WNAE directly tackles the problem of outlier reconstruction, a common failure mode of autoencoders in anomaly detection tasks.

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