Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 15/01/2026
• Auteurs : Ryma BenrabahÉmilien GirotJean-Marc CommengeRené FournetPhilippe ArnouxPierre-Alexandre GlaudeBaptiste Sirjean
• Organismes : Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Département de Chimie Physique des Réactions Laboratoire Réactions et Génie des Procédés
• Publié dans Chemical Engineering Science le 29/10/2020

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Résumé : Liquid phase oxidation reactions are widely studied and optimized for industrial processes of interest such as the oxidation of cyclohexane. The slow oxidation of hydrocarbons, which takes place throughout their chain of use, is the cause of fuel deterioration known as fuel ageing. In recent years, the use of microfluidic tools for the investigation of such processes is expanding with the development of the technologies. Microfluidics enables the use of explosive conditions in a safer way than traditional processes and these tools can be adapted for the kinetic study of the oxidation of ground fuels and jet fuels. Their kinetics of oxidation are slow, and their study requires long residence times, which are not usually reached in the microfluidic field. The PEEK-ACHU rig, a microfluidic device with a heated silicon/glass microfluidic reactor designed for long residence times (from 16 min up to 230 min) and high pressure (up to 40 bar), was developed for the study of slow oxidation reactions of organic compounds. This work presents the design of the reactor and proposes a hydrodynamic study of the gas-liquid Taylor flow implemented in this tool to enable the study of oxidation reactions of fuels. A good understanding of the different diphasic flow regimes as a function of gas bubble generation was obtained for conditions in the explosive range. A correlation was found between the density and viscosity of a fuel and the length of gas bubbles and liquid slugs. The thickness of the residual liquid film at the wall and the reaction regime were characterized and demonstrate that the design of our microreactor enables the kinetic study of organic compounds oxidation, without oxygen mass transfer limitations, at high temperature and high pressure, for very long residence times.

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Fichiers liés : microfluidic_article_R1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Margherita FabbriAymeric LanoreNathalie BertilleJean-Christophe CorvolOlivier J. RascolPhilippe RémyLuc DefebvreChloé LaurencinJean-Philippe AzulaySolène FrismandPhilppe DamierCaroline Giordana ReutherFazia Mélissa TirClaire ThiriezGwendoline DupontJean-Luc HouetoChristian GenyGiovanni CastelnovoAnne Doe de MaindrevilleSophie DrapierDavid MaltêteSolène AnsquerMatthieu AnheimFlorence TubachChristine Brefel-Courbon
• Organismes : Centre d'investigation clinique de Toulouse Toulouse NeuroImaging Center Institut du Cerveau = Paris Brain Institute Centre de pharmacoépidémiologie AP-HP Centre de pharmacoépidémiologie AP-HP Centre d'investigation clinique de Toulouse Centre d’Excellence en Maladies Neurodégénératives IMRB - "NeuroPsychologie Interventionnelle" [Créteil] Lille Neurosciences & Cognition - U 1172 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [CHRU Nancy] Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Service de Neurologie [CHU Nice] CIC Poitiers – Centre d'investigation clinique de Poitiers Service de neurologie [CHU de Poitiers] Service de Neurologie [Strasbourg] Service de neurochirurgie [CHU Dijon] Epidémiologie des Maladies Chroniques en zone tropicale Service de Neurologie [CHU Limoges] CHU Montpellier = Montpellier University Hospital Service de Neurologie [CHU Nimes] Service de neurologie [Reims] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service de neurologie [Rouen] CIC Poitiers – Centre d'investigation clinique de Poitiers Service de Neurologie [Strasbourg] Institut Pierre Louis d'Epidémiologie et de Santé Publique Pharmacoépidémiologie et évaluation des soins [iPLesp] Centre de pharmacoépidémiologie AP-HP Toulouse NeuroImaging Center Centre d'investigation clinique de Toulouse
• Publié dans Parkinsonism & Related Disorders le 02/11/2020

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Résumé : Background: Postural abnormalities (PA) and motor complications (MCs, including motor fluctuations - MFs- and levodopa-induced dyskinesia - LIDs) are hallmark of Parkinson's disease (PD) progression, yet their relationship remains poorly understood. Objective: To investigate the association between PA and MCs, motor symptoms, and non-motor symptoms (NMS) in patients with PD, and to assess whether PA influences the development of MCs over time. Methods: Data of the prospective NS-Park cohort (27 French PD Expert Centers) were analysed. PA was defined by a score ≥2 on item 3.13 of the MDS-UPDRS-III. Associations between PA and MCs, as well as with other motor symptoms and NMS, were assessed using logistic regression models. We used interval censoring survival models to assess the associations between PA at inclusion and the incidence of MCs. Analyses were adjusted for sex, age, disease duration, dopaminergic dose, and disease severity. Results: Among 13,037 included PD patients (58.7 % male, median age at diagnosis 61 years), 724 (5.6 %) presented with PA. Patients with PA had longer disease duration, higher disease severity, and higher dopaminergic treatment. PA exhibited a higher prevalence of troublesome MFs (OR: 5.96; 95 % CI: 4.25-8.32) and LIDs (OR: 2.81; 95 % CI: 1.79-4.30), while associations with milder MCs were inconsistent. However, PA was not significantly associated with the development of MCs during follow-up. Conclusions: PA are associated with more frequent severe MCs, and a higher burden of motor and NMS, making patient care particularly challenging.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/12/2025
• Auteurs : Jose Villasboas BisnetoStephen SmithDanielle WallaceJean-Pierre MarolleauCarlos Grande GarciaReid MerrymanFrancesc BoschLuca ArcainiAntonio PintoNorma GutierrezBrian TillPierre MorelRocío Figueroa MoraCristina GarcíaSara RattottiLucie AubergeonLaurent ChêneJan FagerbergPier Luigi ZinzaniPhilippe ArmandJonathan FriedbergStephen Ansell
• Organismes : Mayo Clinic [Rochester] Fred Hutchinson Cancer Research Center [Seattle] Wilmot Cancer Institute [Rochester] Service d'Hématologie Clinique et Thérapie Cellulaire [CHU Amiens] HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Universidad de Navarra [Pamplona] Dana-Farber Cancer Institute [Boston] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Istituto Nazionale Tumori IRCCS Fondazione G. Pascale [Naples, Italy] Instituto de Investigación Biomédica de Salamanca Service de radiothérapie [CHU Amiens] Universidad de Navarra [Pamplona] Vall d'Hebron University Hospital [Barcelona] Fondazione IRCCS Policlinico San Matteo [Pavia] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Fred Hutchinson Cancer Research Center [Seattle] Alma Mater Studiorum Università di Bologna = University of Bologna Dana-Farber Cancer Institute [Boston] University of Rochester [USA] Mayo Clinic [Rochester]

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Résumé : Background Follicular lymphoma (FL) is a generally indolent disease where a watch and wait strategy is standard in asymptomatic patients (pts) with a low tumor-burden. Harnessing antitumor immunity through an anti-tumor immunization strategy at this stage may delay or avoid the subsequent need for more toxic and complex therapies. EO2463 is a therapeutic vaccine designed from non-self protein sequences, derived from gut bacteria, including 4 HLA-A2 synthetically produced 9-mer CD8 cytotoxic T cell epitopes, exhibiting molecular mimicry with specific epitopes on the B cell markers CD20, CD22, CD37, and CD268 (BAFF-receptor). Additionally, EO2463 contains a CD4 helper epitope UCP2 derived from hTERT. The compound expands pre-existing memory CD8 T cells recognizing the non-self protein sequences from gut bacteria which can then cross-react with the selected B cell antigens on tumor cells. EO2463 is being used to drive anti-tumor immunity against B cell malignancies, and has demonstrated long-lasting, specific CD8-memory T cell responses and clinical activity in relapsed/refractory FL and marginal zone lymphoma (MZL) [J Clinical Oncol 2024, 42 (S16), 7058]. Furthermore, CD8 T cells expanded from samples of patients treated with EO2463 can kill HLA-A2 expressing lymphoblastoid cell lines presenting the B cell targets [Hematological Oncol 2023, 41 (S2), 581-582]. Methods The current report describes Cohort 2 of trial EONHL1-20/SIDNEY (NCT04669171) and includes pts with newly diagnosed, previously untreated FL, grade 1-3A, HLA-A2, and not in need of treatment. Pts receive EO2463 (300μg/peptide) SC with adjuvant Montanide ISA 51 VG, q2 weeks (w) x 4, then q4w, for a total of 12 doses (39w; PET-CTs at w6, w19, and w42). Planned accrual for this cohort is 25 pts. Immune responses were assayed on thawed pt peripheral blood mononuclear cells by flow cytometry and EO2463 peptide specific tetramers or by IFN-γ ELISPOT (assaying responses against 9-mer peptides from CD20, CD22, CD37, and CD268; and from peptides of EO2463) without any proceeding in vitro stimulation (ex vivo). Results As of June 2024, 15 pts had started study treatment. Median age was 62 (range 55-66) year, 7 male and 6 female, 2 pts Ann Arbor stage I/II, 5 stage III, and 8 stage IV. Ten of 15 pts were still on treatment; median treatment duration was 18.4 weeks (range 5-39 w) for all pts. Among 13 evaluable pts, best responses by PET-CT using Lugano criteria were 1 pt CR, 5 pts PR (46% objective responses (OR)), 3 pts SD, and 4 pts PD. Of those with PD per Lugano, 2 had isolated increases in FDG-uptake without increase in lesion size/number at w6 and both remain on treatment (per protocol based on LYRIC criteria). OR was first noted w6 in 3 pts and w19 in 3 pts; duration of response is not evaluable at this time due to short follow-up. The pt with CR had isolated increases in FDG-uptake at w6, PR at w19, and CR at w35. Anti-EO2463 immune responses were observed in 4 of 5 tested pts at the 1st testing timepoint (w5) and onwards (currently longest tested up until w31). In an exploratory analysis, the percentage of EO2463 peptide specific CD8 T cells measured by tetramers seemed linked to clinical response (OR 3 pts vs non-OR 2 pts; 2-sided T-test, p=0.02; range of percentages in pts with OR 0.85%-1.39% of all CD8 T cells in peripheral blood, range in pts with non-OR 0.17%-0.27%). Functionality and cross-reactivity of responses were shown by IFN-γ ELISPOT using 9-mer peptides corresponding to the B cell targets in 4 tested pts. Expanded antigen-specific CD8 T cells displayed a memory phenotype; effector/memory (TEM), and terminally differentiated effector memory CD8 T cells (TEMRA). The most common related AEs were grade 1 (7 pts) and grade 2 (5 pts) local administration site reactions (mainly erythema, pruritus, and induration). Other related AEs in > 1 pt were grade 1 headache (2 pts) and grade 1-3 fatigue/asthenia (3 pts). Asthenia lasting 2 days was the only related grade 3 adverse event (AE). Conclusions EO2463 monotherapy is associated with a very manageable safety profile and appears to demonstrate meaningful single-agent efficacy in FL. Consistent with the preclinical hypothesis, expansion of specific CD8 memory T cells may be associated with response. Results will be expanded at the meeting. Study EONHL1-20/SIDNEY also includes cohorts, not covered in this abstract, exploring EO2463 plus rituximab for 1st line FL/MZL, and EO2463 plus lenalidomide/rituximab in relapsed FL/MZL.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 02/12/2025
• Auteurs : Saeed AbbasluAdam Abed AbudRoberto AcciarriLuiz Paulo AccorsiMario AceroMarcio AdamesGeorge AdamovMark AdamowskiCris AdrianoFaiza AkbarFrancesca AlemannoNimmy Sarah AlexKyle AllisonMunera AlrashedAndrew AltonRodrigo AlvarezTiago AlvesAdil AmanHamza AmarPablo AmedoJohn AndersonDiego Andrade AldanaCostas AndreopoulosMirco AndreottiMichael P AndrewsFenompanirina AndrianalaSofia AndringaFleuri AnjarazafySaeed AnsarifardDiana AnticMarcelo AntoniassiAlfredo Aranda-FernandezLuciano ArellanoEnrique Arrieta DiazManuel ArroyaveMaria ArteroponsJonathan AsaadiMarvin AscencioAdi AshkenaziDavid AsnerLily AsquithEdward AtkinDidier AugusteAdam AurisanoVladimir AushevDario AutieroDaniel Ávila GómezMuhammad Bilal AzamFarrukh AzfarAshley BackJohn BackYuri BaeIuri BagaturiaLinda BagbyDosbol BaigarashevSupraja BalasubramanianAnna BalboniPierre BaldiWander BaldiniJacobo BaldonedoBruce BallerBindu BambahFernando BaraoDenis BarbuGabriela BarenboimPablo Barham AlzásGary BarkerWayne BarkhouseGiles BarrAdilson BarrosNuno BarrosDaniel BarrowJoshua BarrowAnastasia Basharina-FreshvilleAmit BashyalVincent BasqueMarco BassaniDhrubojyoti BasuCharlie BatchelorLars Bathe-PetersJames BattatFederico BattistiJanelly BautistaFatih BayJosé Luis Bazo AlbaJohn BeacomEdouard BechetoilleBiswaranjan BeheraEwerton BelchiorBeryl BellGerard BellLeo BellantoniGiorgio BellettiniVincenzo BelliniOlga BeltramelloAndrey BelyaevCarlos Benitez MontielDouglas BenjaminFrancisco Bento NevesJoshua BergerSophie BerkmanJudilka BermudezJavier BernalPaolo BernardiniAndrea BersaniEmilie BertholetElenora BertoliniSergio BertolucciMinerba BetancourtAmalia Betancur RodríguezYashwanth BezawadaAnibal BezerraAvinay BhatVipin BhatnagarMaharnab BhattacharjeeSaikat BhattacharjeeMeghna BhattacharyaShyam BhullerBipul BhuyanSimone BiagiJianming BianKurt BieryBurak BilkiMary BishaiAndrew BlakeFlor BlaszczykGerald BlazeyEdward BlucherBenjamin BogartJan BoissevainSara BolognesiTimothy BoltonLuca BombenMaurizio BonesiniCesar Bonilla-DiazAlexander BoothFatma BoranRafael Borges MerloNilay BostanGabriel BotogoskeBianca BottinoRaphael BouetJacob BozaJuraj BracinikBarnali BrahmaDominic BrailsfordFilippo BramatiAntonio BrancaAndrew BrandtJohan BremerStephen BriceVanessa BrioClaudia BrizzolariCarl BrombergJim BrookeAlan BrossGiulia BrunettiMaria Brigida BrunettiNorman BuchananHoward BuddJonas BuergiAaron BundockDustin BurgardtSophie ButchartGian Caceres VeraRoberta CalabreseRoberto CalabreseJacob CalcuttLivio CaliversEnrique CalvoAlessio CaminataAmelia CaminoWallison CampanelliAlice CampaniAxel Campos BenitezNicola CanciJordi CapóIoana CaracasDavid CaratelliDaniel CarberJuan CarcellerGabriella CariniBruno CarlusMateus CarneiroPaolo CarnitiIvan Caro TerrazasHector CarranzaNicholas CarraraLauren CarrollThomas CarrollAlex CarterEnrique CasarejosDenise CasazzaJavier Castaño ForeroFabian Castaño UsugaCesar CastromonteErika Catano-MurCarla CattadoriFabien CavalierFlavio CavannaSandro CentroGiuseppe CeratiCédric CernaAlberto CervelliAnselmo Cervera VillanuevaJaafar ChakraniMichel ChalifourAndrew ChappellAnimesh ChatterjeeBhavesh ChauhanCarlos Chavez BarajasHucheng ChenMu-Chun ChenWen Chao ChenYifan ChenZhengyang ChenDaniel CherdackSimranjit Singh ChhibraCheng-Yi ChiFrancesco ChiapponiRobert ChircoNamitha ChitirasreemadamKihyeon ChoSarah ChoateGweneth ChoiDavid ChokheliPooi ChongBarnali ChowdhuryDavid ChristianMoses ChungEric ChurchMaria Flavia CicalaMagda CicerchiaValentina CiceroRiccardo CioliniPeter ClarkeGordon ClineAlfredo CoccoJoao CoelhoAriel CohenJoaquin CollazoJohann CollotHarrison CombsJanet M ConradLivio ContiTaylor ContrerasMark ConveryKyle ConwaySimone CopelloPaolo CovaCallum CoxLinda CremonesiJosé Crespo-AnadónMichael CrislerEsteban CristaldoJason CrnkovicGordon CroneRyan CrossAndrew CuddClara CuestaYanou CuiFrancesca CurciarelloDavid CussansJoel DaiOlivia DalagerWilliam DallawayRiccardo d'AmicoHelio da MottaZubair DarRobert DarbyLeonardo da Silva PeresQuentin DavidGavin DaviesStefano DaviniJaime DawsonRenan de AguiarPaul DebbinsM. Patrick DecowskiAndre de GouveaPedro de HolandaPaul de JongPablo del Amo SanchezGinevra de LauretisAlain DelbartMaritza DelgadoAndrea Dell'AcquaGiovanni Delle MonacheNicola DelmontePatrick de LurgioGiovanni de MatteisJoao de Mello NetoAna de MendoncaDavid DemuthSteve DennisChris DenshamPeter DentonGrzegorz DeptuchAlbert de RoeckValentina de RomeriJan DetjeJames DevineKarishma DhanmeherRanjan DharmapalanMarco DiasAlejandro DiazJorge S DiazFelix DíazFrancesco Di CapuaAntonio Di DomenicoSergio Di DomizioStefano Di FalcoLetizia Di GiulioPengfei DingLea Di NotoEleonora DiociaiutiGiuseppe Di SciascioViola Di SilvestreCarla DistefanoRoberto Di StefanoRichard DiurbaMilind DiwanZelimir DjurcicStephen DolanMichael DolceMichelle J DolinskiDanilo DomeniciSergio DominguezSimone DonatiSteven DoranDaniel DouglasTristan DoyleFrancois DrielsmaDominique DuchesneauKirsty DuffyKatherine DugasPatrick DunneBhaskar DuttaDaniel A DwyerAlexandre S DyshkantSteven DytmanMichael EadsAntony EarleSijith EdayathDaniel EdmundsJonathan EischWilliam EmarkPanagiotis EnglezosAntonio EreditatoTyler ErjavecCarlos O EscobarJustin EvansErin EwartAnthony EzeribeKevin FaheyAndrea FalconeMattia FaniDaniel FaragherChristian FarneseYasaman FarzanJulian FelixYue FengMarcos Ferreira da SilvaGilles FerryEva FialovaLaura FieldsPeter FilipAmy FilkinsFrank FilthautGiuliana FiorilloMassimiliano FioriniSam FogartyWill ForemanJack FowlerJiri FrancKurt FrancisDomenico FrancoJack FranklinJohn FreemanJack FriedAlex FriedlandMary FucciStu FuessIvan FuricKrzysztof FurmanAndrew FurmanskiRiya GabaAlessandro GabrielliA.M GagoFederico GalizziHugh GallagherMatteo GalliNiccolo GalliceVyacheslav GalymovEnrico GamberiniTrevor GambleRaj GandhiSudeshna GangulyFan GaoShanshan GaoDiego Garcia-GamezMiguel Garcia-PerisFernando GardimSteven GardinerAnna GartmanAnja GauchPaolo GauzziStefano GazzanaGuanqun GeNicolas GeffroyBruno GelliStephen GentLino GerlachAvik GhoshTommaso GiammariaDaniele GibinInes Gil-BotellaAntonio GioiosaSimona GiovannellaAnjan Kumar GiriValerio GiustiDario GnaniOlga GogotaSowjanya GollapinniKeith GollwitzerRicardo GomesLuz Gomez FajardoDiego Gonzalez-DiazJuan Gonzalez-SantomeMaury GoodmanSrubabati GoswamiClaudio GottiJacob GoudeauCarl GraceElena GramelliniRik GranPierre GrangerChristopher GrantDiego GratieriGianfrancesco GrausoPatrick GreenStephen GreenbergClark GriffithKatarzyna GrzelakLinhui GuWenqiang GuVictor GuarinoMarco GuariseRoxanne GuenetteMarco GuerzoniDaniele GuffantiAlberto GuglielmiFlynn GuoAnuj GuptaVikas GuptaGanjendra GurungDaniel GutierrezPawel GuzowskiMarcelo GuzzoSunwoo GwonAlec HabigLeïla HaegelRaheema HafejiLee HagamanAlan HahnJanina HakenmüllerThomas HamernikPhilip HamiltonJonathan HancockMagnus HandleyFabio HappacherBenjamin HarrisDeborah HarrisLetrell HarrisAkeem HartJeffrey HartnellTrevor HartnettJohn HartonTakyua HasegawaCiaran HasnipRobert HatcherSarah HawkinsJonathan HaysMuyuan HeAnne HeaveyKarsten HeegerAlex HeindelJaret HeisePatrick HellmuthLouise HendersonKenneth HernerV HewesAaron Higuera PichardoAlexander HimmelElise HinkleLuciana HirschJason HoJaime Hoefken ZinkJames HoffAnna HolinThomas HolveyCheong HongShunsaku HoriuchiGlenn Horton-SmithRitsuya HosokawaThibaut HoudyBruce HowardRyan HowellIvana HristovaMaxine HronekHank HuaJunying HuangRoger HuangXiaoyan HuangZachary HulcherAdil HussainGregory IlesNikolina IlicAntoniu IliescuRobert IllingworthGianfranco IngrattaAra IoannisianMarcelo Ismerio OliveiraChristopher JacksonVivek JainEric JamesWooyoung JangBenjamin JargowskyDeepika JenaIan JentzChao JiangJunjie JiangAlexandru JipaJay Hyun JoFilipe JoaquimWalker JohnsonCécile JolletRhiannon JonesNikola JovancevicMatthew JudahChang Kee JungKiyoung JungThomas JunkYeon-Jae JwaMonireh KabirnezhadAsher KabothIgor KadenkoOrazaly KalikulovDaisy KalraMustafa KandemirSamikshya KarGeorgia KaragiorgiGurkan KaramanArmin KarcherYannis KaryotakisSiva KasettiLane KashurAbdulrahman KautherNarine KazaryanLingyun KeEdward KearnsPaul KeenerKevin KellyRijeesh KelothErnesto KempOtari KemulariaYoann KermaidicWes KetchumSteve KettellNaseem KhanArsen KhvedelidzeDoojin KimJaesung KimMin Jeong KimSuhyeon KimBonnie KingMatthew KingMichael KirbyAlexander KishJoshua KleinJeffrey KleykampAnezka KlustovaThomas KobilarcikLukas KochKevin KoehlerLisa KoernerDae KohMike KordoskyThomas KoscV. Alan KosteleckyIan KotlerWessel KrahRobert KralikMatthew KramerFrank KrennrichTereza KroupovaShion KubotaMiroslav KubuVitaly KudryavtsevGeorgette KufattyStephen KuhlmannAnkip KumarJason KumarMudit KumarPawan KumarPraveen KumarSindhujha KumaranJan KunzmannVaclav KusThomas KutterJiri KvasnickaTyler LabreeMitchell LachatTeresa LackeyIoana LalăuAndrew LambertBenjamin LandCharles LaneNicholas LaneKarol LangThomas LangfordMark LangstaffFrancesco LanniJacob LarkinPierre LasorakDavid LastAndy LaundrieGiuliano LaurentiEmile LavautHenry LayIonel LazanuRyan LazurMassimo LazzaroniTrung LeSara LeardiniJohn LearnedThomas LecompteGiovanna Lehmann MiottoRalf LehnertMatthaeus LeitnerHannah LemoineDiana Leon SilverioLuis LepinJiaoyang LiShirley W LiYichen LiRodrigo LimaCheng-Ju Stephen LinDennis LindebaumSteven LindenRoberto LinerosAdam ListerBryce LittlejohnJunze LiuYinrui LiuSarah LockwitzIrakli LomidzeKen LongJorge Lopez BoteroIgnacio López de RegoNeus López-MarchJohn M LoseccoAdrian Lozano SanchezXianguo LuKam-Biu LukXiao LuoEleonora LuppiAna Amelia MachadoPedro MachadoChristopher Thomas MaciasJolie R MacierMargot MacmahonSteve MagillChristopher MagueurKendall MahnAmélia MaioNabila MajeedAdryanna MajorKrishanu MajumdarAkshay MaligeSaverio MameliMatthew ManRoberto MandujanoJosé ManeiraSteve ManlyAnthony MannKonstantinos ManolopoulosMaria Manrique PlataSergio Manthey CorchadoLuis Manzanillas-VelezEdgar MaoMiquel MarchanAlberto MarchionniDanny MarfatiaCamillo MarianiJelena MaricicFranciole MarinhoAlysia MarinoThomas MarkiewiczFrancisco MarquesMarvin MarshakChris MarshallJohn MarshallLuigi MartinaJusto Martín-AlboDavid Martinez CaicedoMaria Martinez-CasalesFrancisco Martínez LópezSergey MartynenkoValerio MascagnaAndrew MastbaumMehedi MasudFabrice MatichardGiuseppe MatteucciJames MatthewsChristopher MaugerNicoletta MauriKonstantinos MavrokoridisIsobel MawbyFinn MayhewTracy McaskillNicola McconkeyBrenna McconnellKevin McfarlandCarrie McgivernClark McgrewAndrew McnabCynthia McnultyJames MeadLuca MeazzaVaruna Crishan Nimalasooriya MeddageAbinash MedhiMaria MehmoodBhumika MehtaPoonam MehtaFilippo MeiPantelis MelasLucile MelletTatiana MeloOlga MenaHector MendezDiana MéndezA MenegolliGuang MengAretha MercuriAnselmo MeregagliaMark MessierSteven MetalloWilliam MetcalfMatthew MewesHolger MeyerTing MiaoJessie MicallefAlessandro MiccoliGregory MichnaRadovan MilincicFranklin MillerGraham MillerWilliam MillerAlessandro MinottiLuis Miralles VergeCamelia MironovStefano MiscettiC. Shekhar MishraPriya MishraSanjib R MishraDimitar MladenovIrina MocioiuAndrew MoganRukmani MohantaTanaz MohayaiNikolai MokhovJorge MolinaLaura Molina BuenoElisabetta MontagnaAlessandro MontanariClaudio MontanariDavid MontanariDaniele MontaninoLuis Montaño ZetinaMichael MooneyAlexandra MoorMiriam MooreZae MooreDeywis MorenoG Moreno-GranadosOscar Moreno-PalaciosLuca MorescalchiCasandra MorrisErdem MotukCélio MouraGwenn MousterWei MuLeon MualemJustin MuellerMathew MuetherFranz MuheimAlan MuirYerzhan MukhamejanovAssel MukhamejanovaMike MulhearnDonnie MunfordLaura MunteanuHajime MuramatsuJean-Francois MurazMatt MurphyThomas MurphyAngeliki MytilinakiJane NachtmanYoshikazu NagaiSrishti NaguDonna NaplesShinya NaritaJacopo NavaAnyssa Navrer-AgassonNitish NayakMiquel Nebot-GuinotAsa NehmJeff NelsonOrgho NeogiJake NesbitMarzio NessiDavid NewboldMitch NewcomerDarcy NewmarkRyan NicholFrancisco Nicolas-ArnaldosAj NielsenAdrian NikolicaJovana NikolovEvan NinerXuyang NingKurtis NishimuraAndrew NormanAnne NorrickFrancesco NotoPau NovellaAgnieszka NowakJaroslaw NowakMichael OberlingJuan Pedro Ochoa-RicouxSeog OhSungbin OhAndrew OlivierTravis OlsonYasar OnelYuriy OnishchukAlejandro OrandayMatthew OsbistonJaime Osorio VélezLiam O'SullivanLuis Otiniano OrmacheaLuca PaganiGuillermo PalacioOrnella PalamaraSandro PalestiniJonathan PaleyMarco PallaviciniCarmen PalomaresSupriya PanMarco PanareoPapia PandaVishvas PandeyWilliam Panduro VazquezEmilija PanticVittorio PaoloneAfroditi PapadopoulouRiccardo PapaleoDimitrios PapouliasSudarshan ParamesvaranJuseong ParkStephen ParkeSaba ParsaSabila ParveenMihaela ParvuDaniele PasciutoSilvia PascoliLaura PasqualiniJaroslaw PasternakGracee PatelJosephine PatonCheryl PatrickLaura PatriziiRyan PattersonThomas PatzakAjib PaudelJasper PaulLaura PaulucciZarko PavlovicGreg PawloskiDavid PayneAbigail PeakeViktor PecElena PedreschiSimon PeetersWilliam PellicoElisabetta PennacchioAldo PenzoOrlando PeresYuber Ferney Perez GonzalezLaura Pérez-MolinaCarlos PernasJames PerryDaniel PersheyGianluigi PessinaGianluca PetrilloCatia PettaRoberto PettiMarvin PfaffValerio PiaGiovanni Maria PiacentinoLuke PickeringLorenzo PieriniFrancesco PietropaoloVinicius PimentelGiovanni PinaroliShailesh PinchaJoshua PinchaultKevin PittsPawel PlesniakKatherine PletcherKomninos-John PlowsCesar PollackTina PollmannFederica PompaMaria Artero PonsXavier PonsNavaneeth PoonthottathilVitaliy PopovFrancesco PoppiJoshua PorterLuis Gustavo Porto PaixãoMaxim PotekhinMichele PozzatoRitesh PradhanTarun PrakashMichela PrestFernanda PsihasDenis PugnereDario PulliaXin QianJoshua QueenJennifer L RaafMiranda RabelhoferVeljko RadekaJonas RademackerFabrizio RaffaelliAleena RafiqueAlexander RaheSrini RajagopalanMiriama RajaoalisoaIgor RakhnoLaza RakotondravohitraMamitiana Angelo RalaikotoLalnuntluanga RalteManuel Alejandro Ramirez DelgadoBryan RamsonSteve Stone RandriamanampisoaA RappoldiG.L RaselliTyler RathPeter RatoffRon RayHerilala RazafinimeRado Fanantenana RazakamiandraEran 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• Organismes : Laboratoire de l'Accélérateur Linéaire Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Commissariat à l'énergie atomique et aux énergies alternatives Laboratoire de Physique des Deux Infinis Bordeaux Institut de Physique des 2 Infinis de Lyon Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie AstroParticule et Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Institut de Physique des 2 Infinis de Lyon AstroParticule et Cosmologie Laboratoire d'Annecy de Physique des Particules Institut de Physique des 2 Infinis de Lyon Commissariat à l'énergie atomique et aux énergies alternatives Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique des Deux Infinis Bordeaux AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire Laboratoire de Physique des Deux Infinis Bordeaux Laboratoire d'Annecy de Physique des Particules Laboratoire de l'Accélérateur Linéaire Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de l'Accélérateur Linéaire Laboratoire de l'Accélérateur Linéaire Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Institut de Physique des 2 Infinis de Lyon Laboratoire d'Annecy de Physique des Particules Institut de Physique des 2 Infinis de Lyon AstroParticule et Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de l'Accélérateur Linéaire Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Institut de Physique des 2 Infinis de Lyon Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie AstroParticule et Cosmologie AstroParticule et Cosmologie Laboratoire d'Annecy de Physique des Particules

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Résumé : We present the measurement of $π^{+}$--argon inelastic cross sections using the ProtoDUNE Single-Phase liquid argon time projection chamber in the incident $π^+$ kinetic energy range of 500 -- 800 MeV in multiple exclusive channels (absorption, charge exchange, and the remaining inelastic interactions). The results of this analysis are important inputs to simulations of liquid argon neutrino experiments such as the Deep Underground Neutrino Experiment and the Short Baseline Neutrino program at Fermi National Accelerator Laboratory. They will be employed to improve the modeling of final state interactions within neutrino event generators used by these experiments, as well as the modeling of $π^{+}$--argon secondary interactions within the liquid argon. This is the first measurement of $π^+$--argon absorption at this kinetic energy range as well as the first ever measurement of $π^{+}$--argon charge exchange.

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 02/12/2025
• Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengDawei FuBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangMingtao ZhangYuzhe ZhaoChen ZhouShuai 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Résumé : A search for heavy resonances decaying into a Higgs boson (H) or a Z boson and a photon ($γ$), with the H or Z bosons decaying to a bottom quark-antiquark pair ($\mathrm{b\bar{b}}$) is presented. The analysis is performed using proton-proton collision data at $\sqrt{s}$ = 13 TeV collected by the CMS experiment at the CERN Large Hadron Collider, corresponding to an integrated luminosity of 138 fb$^{-1}$. The analyzed events contain a photon and a massive large-radius jet originating from a Lorentz-boosted $\mathrm{b\bar{b}}$ system. An advanced transformer-based algorithm classifies jets according to their substructure and quark flavors, forming a tagger that identifies jets as candidates from H/Z $\to$$\mathrm{b\bar{b}}$ decays. A set of parametric functions is used to fit the photon-jet invariant mass spectrum and to extract potential signals. No significant excess is observed above the standard model expectations. The results set upper limits at 95% confidence level on the product of the cross section and the branching fraction for spin-1 H$γ$ resonances and spin-0 Z$γ$ resonances, below 0.1 and 0.3 fb, respectively, representing the most stringent limits to date.

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