Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Pierre PradatSolene PantelMarianne MaynardLaure LalandeSylvie ThevenonRene AdamMarc-Antoine AllardFabien RobinMichel RayarEmmanuel BoleslawskiOlivier ScattonMircea ChiricaFrançois FaitotPhilippe BachellierOlivier SoubraneKayvan MohkamJean‐yves MabrutMickaël Lesurtel
• Organismes : Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon
• Publié dans Trials le 31/10/2020

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Résumé : Abstract Background Given the scarce donor supply, an increasing number of so-called marginal or extended criteria donor (ECD) organs are used for liver transplantation. These ECD liver grafts are however known to be associated with a higher rate of early allograft dysfunction and primary non-function because of a greater vulnerability to ischemia–reperfusion injury. The end-ischemic hypothermic oxygenated machine perfusion (HOPE) technique may improve outcomes of liver transplantation with ECD grafts by decreasing reperfusion injury. Methods HOPExt trial is a comparative open-label, multicenter, national, prospective, randomized, controlled study, in two parallel groups, using static cold storage, the gold standard procedure, as control. The trial will enroll adult patients on the transplant waiting list for liver failure or liver cirrhosis and/or liver malignancy requiring liver transplantation and receiving an ECD liver graft from a brain-dead donor. In the experimental group, ECD liver grafts will first undergo a classical static cold (4 °C) storage followed by a hypothermic oxygenated perfusion (HOPE) for a period of 1 to 4 h. The control group will consist of the classic static cold storage which is the gold standard procedure in liver transplantation. The primary objective of this trial is to study the efficacy of HOPE used before transplantation of ECD liver grafts from brain-dead donors in reducing postoperative early allograft dysfunction within the first 7 postoperative days compared to simple cold static storage. Discussion We present in this protocol all study procedures in regard to the achievement of the HOPExt trial, to prevent biased analysis of trial outcomes and improve the transparency of the trial results. Enrollment of patients in the HOPExt trial has started on September 10, 2019, and is ongoing. Trial registration ClinicalTrials.gov NCT03929523. Registered on April 29, 2019, before the start of inclusion.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Jean-François David CadranelIsabelle Ollivier-HourmandJacques CadranelThierry ThevenotHonoré ZougmoreEric Nguyen-KhacChristophe BureauManon AllaireJean-Baptiste NousbaumVéronique Loustaud-RattiXavier CaussePhilippe SogniBertrand HanslikMarc BourliereJean-Marie PeronNathalie Ganne-CarrieThong DaoDominique ThabutBernard. MaitreNabil DebziRyad SmadhiRoger SombieRaimi KpossouOlivier NouelJulien BissonnetteIsaac RuizMourad MedmounSergio Negrin DastisPierre DeltenreFlorent ArtruChantal RaherisonLaure ElkriefTristan Lemagoarou
• Organismes : CHU Caen Service d'Hépatologie [CHRU Besançon] CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 Centre Hospitalier Universitaire de Toulouse Centre de recherche sur l'Inflammation CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire de Brest Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation Institut Cochin Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Hôpital Saint-Joseph [Marseille] Centre Hospitalier Universitaire de Toulouse Hôpital Avicenne [AP-HP] Centre de Recherche des Cordeliers CHU Caen CHU Pitié-Salpêtrière [AP-HP] Centre de recherche en épidémiologie et santé des populations Service Addictologie [CHU Nîmes] Sorbonne Université Centre Hospitalo-Universitaire Mustapha Bacha
• Publié dans BMC Gastroenterology le 01/11/2020

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Résumé : Background The Hepatic hydrothorax is a pleural effusion related to portal hypertension; its diagnosis and therapeutic management may be difficult. The aims of this article are which follows: To gather the practices of hepatogastroenterologists or pulmonologists practitioners regarding the diagnosis and management of the hepatic hydrothorax. Methods Practitioners from 13 French- speaking countries were invited to answer an online questionnaire on the hepatic hydrothorax diagnosis and its management. Results Five hundred twenty-eight practitioners (80% from France) responded to this survey. 75% were hepatogastroenterologists, 20% pulmonologists and the remaining 5% belonged to other specialities. The Hepatic hydrothorax can be located on the left lung for 64% of the responders (66% hepatogastroenterologists vs 57% pulmonologists; p = 0.25); The Hepatic hydrothorax can exist in the absence of clinical ascites for 91% of the responders (93% hepatogastroenterologists vs 88% pulmonologists; p = 0.27). An Ultrasound pleural scanning was systematically performed before a puncture for 43% of the responders (36% hepatogastroenterologists vs 70% pulmonologists; p < 0.001). A chest X-ray was performed before a puncture for 73% of the respondeurs (79% hepatogastroenterologists vs 54% pulmonologists; p < 0.001). In case of a spontaneous bacterial empyema, an albumin infusion was used by 73% hepatogastroenterologists and 20% pulmonologists ( p < 0.001). A drain was used by 37% of the responders (37% hepatogastroenterologists vs 31% pulmonologists; p = 0.26).An Indwelling pleural catheter was used by 50% pulmonologists and 22% hepatogastroenterologists ( p < 0.01). TIPS was recommended by 78% of the responders (85% hepatogastroenterologists vs 52% pulmonologists; p < 0.001) and a liver transplantation, by 76% of the responders (86% hepatogastroenterologists vs 44% pulmonologists; p < 0.001). Conclusions The results of this large study provide important data on practices of French speaking hepatogastroenterologists and pulmonologists; it appears that recommendations are warranted.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Saber Davide BarbarAbderrahmane BourredjemRémi TrussonAuguste DargentChristine BinquetJean-Pierre QuenotRaphaël Clere-JehlRomain HernuFlorent MontiniRémi BruyèreChristine LebertJulien BohéJulio BadieJean-Pierre EraldiJean-Philippe RigaudBruno LevyShidasp SiamiGuillaume LouisLila BouadmaJean-Michel ConstantinEmmanuelle MercierKada KloucheDamien Du CheyronGaël PitonDjillali AnnaneSamir JaberTherry van der LindenGilles BlascoJean-Paul MiraCarole SchwebelLoïc ChimotPhilippe GuiotMai-Anh NayFerhat MezianiJulie HelmsClaire RogerBenjamin Louart
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background This substudy of the randomized IDEAL-ICU trial assessed whether the timing of renal replacement therapy (RRT) initiation has a differential effect on 90-day mortality, according to the criteria used to diagnose acute kidney injury (AKI), in patients with early-stage septic shock. Methods Three groups were considered according to the criterion defining AKI: creatinine elevation only (group 1), reduced urinary output only (group 2), creatinine elevation plus reduced urinary output (group 3). Primary outcome was 90-day all-cause death. Secondary endpoints were RRT-free days, RRT dependence and renal function at discharge. We assessed the interaction between RRT strategy (early vs. delayed) and group, and the association between RRT strategy and mortality in each group by logistic regression. Results Of 488 patients enrolled, 205 (42%) patients were in group 1, 174 (35%) in group 2, and 100 (20%) in group 3. The effect of RRT initiation strategy on 90-day mortality across groups showed significant heterogeneity (adjusted interaction p = 0.021). Mortality was 58% vs. 42% for early vs. late RRT initiation, respectively, in group 1 ( p = 0.028); 57% vs. 67%, respectively, in group 2 ( p = 0.18); and 58% vs. 55%, respectively, in group 3 ( p = 0.79). There was no significant difference in secondary outcomes. Conclusion The timing of RRT initiation has a differential impact on outcome according to AKI diagnostic criteria. In patients with elevated creatinine only, early RRT initiation was associated with significantly increased mortality. In patients with reduced urine output only, late RRT initiation was associated with a nonsignificant, 10% absolute increase in mortality.

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Fichiers liés : 2023 Barbar et al., Differential.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Jade RoyoBertin VianouManfred AccrombessiElisée KinkpéLinda AyédadjouIda Dossou-DagbaYélé LadipoMaroufou Jules AlaoGwladys BertinMichel CotFarid BoumédièneSandrine HouzéJean François FaucherAgnès AubouyDissou AffolabiDaniel AjzenbergBibiane BiokouJosselin BrissetJean-Eudes DegbeloPhilippe DeloronLatifou DramaneSayeh Jafari-GuemouriClaire KamaliddinAnaïs LabrunieThomas LathiereAchille MassougbodjiAudrey MowendabekaJade PapinBernard PipyPierre-Marie PreuxMarie RaymondeauDarius SossouBrigitte TecherLaurence Watier
• Organismes : Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Infectious Diseases of Poverty le 27/10/2020

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Résumé : Abstract Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest forms of malaria among African children. The kinetics of the pathophysiological mechanisms leading to neuroinflammation and the death or survival of patients during CM are still poorly understood. The increasing production of cytokines, chemokines and other actors of the inflammatory and oxidative response by various local actors in response to neuroinflammation plays a major role during CM, participating in both the amplification of the neuroinflammation phenomenon and its resolution. In this study, we aimed to identify risk factors for CM death among specific variables of inflammatory and oxidative responses to improve our understanding of CM pathogenesis. Methods Children presenting with CM ( n = 70) due to P. falciparum infection were included in southern Benin and divided according to the clinical outcome into 50 children who survived and 20 who died. Clinical examination was complemented by fundoscopic examination and extensive blood biochemical analysis associated with molecular diagnosis by multiplex PCR targeting 14 pathogens in the patients’ cerebrospinal fluid to rule out coinfections. Luminex technology and enzyme immunoassay kits were used to measure 17 plasma and 7 urinary biomarker levels, respectively. Data were analysed by univariate analysis using the nonparametric Mann‒Whitney U test and Pearson’s Chi2 test. Adjusted and multivariate analyses were conducted separately for plasma and urinary biomarkers to identify CM mortality risk factors. Results Univariate analysis revealed higher plasma levels of tumour necrosis factor (TNF), interleukin-1beta (IL-1β), IL-10, IL-8, C-X-C motif chemokine ligand 9 (CXCL9), granzyme B, and angiopoietin-2 and lower urinary levels of prostanglandine E2 metabolite (PGEM) in children who died compared to those who survived CM (Mann–Whitney U -test, P -values between 0.03 and < 0.0001). The multivariate logistic analysis highlighted elevated plasma levels of IL-8 as the main risk factor for death during CM (adjusted odd ratio = 14.2, P -value = 0.002). Values obtained during follow-up at D3 and D30 revealed immune factors associated with disease resolution, including plasma CXCL5, C–C motif chemokine ligand 17 (CCL17), CCL22, and urinary 15-F2t-isoprostane. Conclusions The main risk factor of death during CM was thus elevated plasma levels of IL-8 at inclusion. Follow-up of patients until D30 revealed marker profiles of disease aggravation and resolution for markers implicated in neutrophil activation, endothelium activation and damage, inflammatory and oxidative response. These results provide important insight into our understanding of CM pathogenesis and clinical outcome and may have important therapeutic implications. Graphical Abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Bernard CholleyMirela BojanBenoit GuillonEmmanuel BesnierMathieu MatteiBruno LevyAlexandre OuattaraNadir TaferClément DelmasDavid TononBertrand RozecJean-Luc FellahiPascal LimFrançois LabasteFrançois RoubilleThibaut CarubaPhilippe MauriatOlivier BarbotBerthomieu LaurentAnne-Marie BesselatBlanchart KatrienAdrien BouglePierre BourgoinCauseret ArnaudHélène CharbonneauMircea CristinarOlivier DesebbeVeldat EljeziThibaud GenetMaxime GrenierPierre Grégoire GuinotStéphane LebelYael LevyFrançois LionJacques MansouratiStéphanie MarlièreAnne-Céline MartinAlexandre MebazaaUsman MohammadJacques MonseguNicolas NesslerIsabelle OrselEtienne PuymiratMorgan RecherSabri SoussiVincent TroussardSabrina UhryXavier Zirphile
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied.

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Fichiers liés : 2023 Chollet et al., Overview of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : William YoungJeffrey HaesslerJan-Walter BenjaminsLinda RepettoJie YaoAaron IsaacsAndrew HarperJulia RamirezSophie GarnierStefan van DuijvenbodenAntoine BaldassariMaria Pina ConcasThuyvy DuongLuisa FocoJonas IsaksenHao MeiRaymond NoordamCasia NursyifaAnne RichmondMeddly SantolallaColleen SitlaniNegin SoroushSébastien ThériaultStella TrompetStefanie AeschbacherFariba AhmadizarAlvaro AlonsoJennifer BrodyArchie CampbellAdolfo CorreaDawood DarbarAntonio de LucaJean-François DeleuzeChristina EllervikChristian FuchsbergerAnuj GoelChristopher GraceXiuqing GuoTorben HansenSusan HeckbertRebecca JacksonJan KorsMaria Fernanda Lima-CostaAllan LinnebergPeter MacfarlaneAlanna MorrisonPau NavarroDavid PorteousPeter PramstallerAlexander ReinerLorenz RischUlrich SchottenXia ShenGianfranco SinagraElsayed SolimanMonika StollEduardo Tarazona-SantosAndrew TinkerKaterina TrajanoskaEric VillardHelen WarrenEric WhitselKerri WigginsDan ArkingChristy AveryDavid ConenGiorgia GirottoNiels GrarupCaroline HaywardJ. Wouter JukemaDennis Mook-KanamoriMorten Salling OlesenSandosh PadmanabhanBruce PsatyCristian PattaroAntonio Luiz P. RibeiroJerome RotterBruno StrickerPim van der HarstCornelia van DuijnNiek VerweijJames WilsonMichele OriniPhilippe CharronHugh WatkinsCharles KooperbergHenry LinJames WilsonJørgen KantersNona SotoodehniaBorbala MifsudPier LambiaseLarisa TereshchenkoPatricia Munroe
• Organismes : Cardiovascular Genomics Cardiovascular Genomics Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Pitié-Salpêtrière [AP-HP] Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires ou Rares [Boulogne-Billancourt] Sorbonne Université Hôpital Ambroise Paré [AP-HP]
• Publié dans Nature Communications le 23/10/2020

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Résumé : Abstract The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle ( N = 118,780) and 11 for the frontal QRS-T angle ( N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Matthieu JabaudonAlexandra GenevrierSamir JaberOlivier WindischStéphanie BulyezPierre-François LaterreEtienne EscudierAchille SossouPhilippe GuerciPierre-Marie BertrandPierre-Eric DaninMartin BonnassieuxLeo BühlerClaudia Paula HeideggerRussell ChabanneThomas GodetLaurence RoszykVincent SapinEmmanuel FutierBruno PereiraJean-Michel ConstantinElodie CaumonJulien AmatDominique MorandRenaud GuérinSébastien PerbetBenjamin RieuSophie CayotChristian ChartierCamille VerlhacChristine RolhionJustine BourdierBernard CosserantRaiko BlondonnetJean-Baptiste JoffredoThomas CostillesDamien BouvierLise BernardJean-Etienne BazinLaurence RoszykLydie Marie-AnneRaphaël GiraudAnnick PuchoisCyril BoronadMarine AgulloBoris JungGérald ChanquesCécile SpiritoMarion MonninAlbert PradesMoussa CisseAnne VerchereClaudine GniadekFouad BelafiaDaniel VerzilliJulie CarrAudrey de JongYannael CoiselJean-Marc DelayMatthieu ConseilMarie GonzalezDelphine RosantMichel PrevotBernard ClaudFrançois BrenasLassane ZanrePhilippe BrayHélène RieraEmilie Gadea-DeschampsPablo MassanetCaroline BoutinSaber BarbarDavid-Paul de BrauwereSerge LumbrosoAmélie MaurinSophie LloretLaurent MullerClaire RogerJean-Yves LefrantLoubna ElotmaniAudrey AyralSuzanne RenardNadège BouskilaGaspard BeauneMagali Farines-RaffoulMarie LeboucAuguste DargentThomas CrozonJulien ClauzelMarinne Le CoreThomas Rimmelé
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in addition to usual care, in improving clinical outcomes of intensive care unit patients with acute pancreatitis. Methods A multicenter, open-label, randomized, controlled trial including adult patients with a clinical diagnosis of acute pancreatitis upon admission to the intensive care unit. Participants were randomly assigned (1:1) to a strategy combining thoracic epidural analgesia and usual care (intervention group) or a strategy of usual care alone (control group). The primary outcome was the number of ventilator-free days from randomization until day 30. Results Between June 2014 and January 2019, 148 patients were enrolled, and 135 patients were included in the intention-to-treat analysis, with 65 patients randomly assigned to the intervention group and 70 to the control group. The number of ventilator-free days did not differ significantly between the intervention and control groups (median [interquartile range], 30 days [15–30] and 30 days [18–30], respectively; median absolute difference of − 0.0 days, 95% CI − 3.3 to 3.3; p = 0.59). Epidural analgesia was significantly associated with longer duration of invasive ventilation (median [interquartile range], 14 days [5–28] versus 6 days [2–13], p = 0.02). Conclusions In a population of intensive care unit adults with acute pancreatitis and low requirement for intubation, this first multicenter randomized trial did not show the hypothesized benefit of epidural analgesia in addition to usual care. Safety of epidural analgesia in this setting requires further investigation. Trial registration : ClinicalTrials.gov registration number NCT02126332 , April 30, 2014.

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Fichiers liés : 2023 Jabaudon et al., Thoracic.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Edouard CaspersenPierre-Grégoire GuinotBertrand RozecJean-Ferréol OilleauJean-Luc FellahiPhilippe GaudardEmmanuel LorneYazine MahjoubEmmanuel BesnierMouhamed Djahoum MoussaNicolas MongardonJean-Luc HanouzAnaïs BriantLaure Peyro Saint PaulClémence TomadessoJean-Jacques ParientiRichard DescampsAlina DenisenkoMarc-Olivier Fischer
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Trials le 31/10/2020

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Résumé : Abstract Background Postoperative atrial fibrillation (PoAF) after cardiac surgery has a high incidence of 30%, but its management is controversial. Two strategies are recommended without evidence of a superiority of one against the other: rate control with beta-blocker or rhythm control with amiodarone. Landiolol is a new-generation beta-blocker with fast onset and short half-life. One retrospective, single-center study compared landiolol to amiodarone for PoAF after cardiac surgery with a better hemodynamic stability and a higher rate of reduction to sinus rhythm with landiolol, justifying the need for a multicenter randomized controlled trial. Our aim is to compare landiolol to amiodarone in the setting of PoAF after cardiac surgery with the hypothesis of a higher rate of reduction to sinus rhythm with landiolol during the 48 h after the first episode of POAF. Methods The FAAC trial is a multicenter single-blind two parallel-arm randomized study, which planned to include 350 patients with a first episode of PoAF following cardiac surgery. The duration of the study is 2 years. The patients are randomized in two arms: a landiolol group and an amiodarone group. Randomization (Ennov Clinical®) is performed by the anesthesiologist in charge of the patient if PoAF is persistent for at least 30 min after correction of hypovolemia, dyskalemia, and absence of pericardial effusion on a transthoracic echocardiography done at bedside. Our hypothesis is an increase of the percentage of patients in sinus rhythm from 70 to 85% with landiolol in less than 48 h after onset of PoAF (alpha risk = 5%, power = 90%, bilateral test). Discussion The FAAC trial was approved by the Ethics Committee of EST III with approval number 19.05.08. The FAAC trial is the first randomized controlled trial comparing landiolol to amiodarone for PoAF after cardiac surgery. In case of higher rate of reduction with landiolol, this beta-blocker could be the drug of choice used in this context as to reduce the need for anticoagulant therapy and reduce the risk of complications of anticoagulant therapy for patients with a first episode of postoperative atrial fibrillation after cardiac surgery. Trial registration ClinicalTrials.gov NCT04223739. Registered on January 10, 2020.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El BaghdadiSara Espinosa-PadillaJosé Luis FrancoAntoine FroidureDavid HaginSarah HenricksonElena HsiehEystein HusebyeKohsuke ImaiYuval ItanErich JarvisTimokratis KaramitrosKai KisandCheng-Lung KuYun LingCarrie LucasLászló MaródiIsabelle MeytsJoshua MilnerKristina MironskaTomohiro MorioLisa NgLuigi NotarangeloCliona O’FarrellySatoshi OkadaAnna PlanasLluis Quintana-MurciLaurent ReniaIgor ResnickCarlos Rodríguez-GallegoVanessa Sancho-ShimizuAnna SedivaMikko SeppänenAnna ShcherbinaOndrej SlabyAndrew SnowPere Soler-PalacínAndrás SpaanIvan TancevskiStuart TangyeSathishkumar RamaswamyStuart TurveyFurkan UddinMohammed UddinDiederik van de BeekDonald VinhMayana ZatzHelen SuJean-Laurent CasanovaSerge BureauYannick VacherAnne Gysembergh-HoualLauren DemervilleAbla ChachouaSebastien AbadRadhiya AbassiAbdelrafie AbdellaouiAbdelkrim AbdelmalekHendy AbdoulHelene AbergelFariza AbeudSophie AbgrallNoemie AbisrorMarylise AdechianNordine AderdourHakeem Farid AdmaneFrederic AdnetSara AfrittHelene AgostiniClaire AguilarSophie AgutTommaso Francesco AielloMarc Ait KaciHafid Ait OufellaGokula AjeenthiravasanVirginie AlauzyFanny Alby-LaurentLucie AllardMarie-Alexandra AlyanakianBlanca Amador BorreroSabrina AmamLucile AmroucheMarc AndronikofDany AnglicheauNadia AnguelDjillali AnnaneMohammed AounzouCaroline AparicioGladys AratusJean-Benoit ArletJeremy ArzoineElisabeth AslangulMona AssefiAdeline AubryLaetitia AudiffredEtienne AudureauChristelle Nathalie AugerJean-Charles AureganCeline AwotarSonia Ayllon MillaDelphine AzanLaurene AzemarBillal AzzouguenMarwa Bachir ElrufaaiAïda BadsiPrissile BakouboulaColine BalcerowiakFanta BaldeElodie BaldiviaEliane-Flore BangamingoAmandine BaptisteFanny Baran-MarszakCaroline BarauNathalie BargetFlore BaronnetRomain BarthelemyJean-Luc BaudelCamille BaudryElodie BaudryLaurent BeaugerieAdel BelamriNicolas BelaubeRhida BelilitaPierre BellassenRawan BelmokhtarIsabel BeltranRuben BenainousMourad BenallaouaRobert BenamouzigAmélie BenbaraJaouad BenhidaAnis 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ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie Cobat
• Organismes : Nutrition et obésités: approches systémiques (UMR-S 1269)
• Publié dans Genome Medicine le 24/10/2020

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Résumé : Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7 , with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10 −4 ) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10 −4 ). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10 −3 ), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10 −8 ). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10 −5 ). Conclusions Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2023
• Auteurs : Mélanie CognéArthur DelayrePauline CoignardJean-Luc Le GuietPierre-Alain JosephIsabelle BonanEric SoritaClaire Le GallPhilippe Azouvi
• Organismes : Bordeaux population health
• Publié dans Annals of Physical and Rehabilitation Medicine le 02/11/2020

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