Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2026
• Auteurs : Maud RothärmelLila MekaouiFrançois KazourMorgane HerreroEva-Maria Beetz-LobonoAiste LengvenyteJérôme HoltzmannPhilippe RaynaudMacarena Cuenca-MaiaSamuel BulteauPierre de MaricourtThomas HussonÉmilie OliéB.GohierAnne SauvagetRaphaël GaillardRaphaëlle RichieriDavid SzekelyLudovic SamalinOlivier GuillinVirginie MoulierWissam El-HageAndrew LaurinLucie Berkovitch
• Organismes : Centre Hospitalier du Rouvray Normandie Université CHU Rouen Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Centre Hospitalier Universitaire d'Angers Pôle Psychiatrie [CHU Saint-Etienne] Centre Hospitalier Princesse Grace Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Centre Hospitalier Léon-Jean Grégory [Thuir] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Centre Hospitalier du Rouvray Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Institut FRESNEL Hôpital Sainte-Marguerite [CHU - APHM] Hôpital Princesse Grace [Monaco] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Centre Hospitalier du Rouvray Normandie Université CHU Rouen Centre Hospitalier du Rouvray Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Centre Hospitalier Régional Universitaire de Tours Imaging, Brain & Neuropsychiatry Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Université Paris Cité
• Publié dans European Journal of Psychotraumatology le 01/11/2020

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Résumé : Background: Posttraumatic stress disorder (PTSD) is a severe and frequent affection that is highly comorbid to major depressive disorder. Comorbid PTSD and depression increase the risk of treatment-resistant depression (TRD), with a high risk of functional impairment and suicide. Esketamine nasal spray is a recent validated treatment for TRD, but its efficacy on comorbid TRD-PTSD remains insufficiently documented. In particular, it is unknown whether traumatic re-experiencing may occur during esketamine treatment and if so, how it influences clinical outcomes.Objectives: Our objective was to describe trauma re-experiencing episodes during esketamine sessions and their impact on clinical trajectories within an ecological sample of patients with comorbid TRD-PTSD.Methods: We retrospectively collected clinical data of patients receiving esketamine nasal spray for TRD for whom at least one trauma re-experiencing episodes had been identified by clinicians during esketamine sessions across 11 psychiatric departments.Results: Between February 2020 and March 2023, 22 adult patients with TRD met inclusion criteria. In sixteen patients (72.7%) trauma re-experiencing episodesdisappeared as the sessions progressed. In six patients (27.3%), esketamine treatment was stopped because of trauma re-experiencing episodes. When esketamine was continued, favourable clinical outcomes were observed both for depression and PTSD (depression response rate: 45.5% and remission rate: 22.7%; PTSD improvement rate: 45.5% and remission: 18.2%).Limitations: The retrospective design of the study and the absence of a comparator group are the main limitations of our study.Conclusions: Our results suggest that esketamine can be safely administered to patients with comorbid PTSD and TRD, and that the occurrence of trauma re-experiencing episodes does not hinder clinical response.

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Fichiers liés : Rothärmel et al 2026.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2026
• Auteurs : Giovanna FancelloBasile ChaixPhilippe GerberYan KestensAlexandre NaudCédric SueurJulie Vallée
• Organismes : Géographie-cités Environnement, Mobilité et Santé [iPLesp] Environnement, Mobilité et Santé [iPLesp] Luxembourg Institute of Socio-Economic Research Centre de Recherche du Centre Hospitalier de l’Université de Montréal Université de Montréal Université de Strasbourg Institut Pluridisciplinaire Hubert Curien Institut universitaire de France Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires Géographie-cités
• Publié dans Social Networks le 30/10/2020

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Résumé : Social interactions and daily mobility are two behaviors that mutually transform throughout life. Understanding how they interact is particularly important for elderly people, who are more at risk to be spatially and socially isolated. From data collected among a sample of 225 people aged 60 and over living in the Paris region (France), we explore how their social interactions are embedded into their activity space using the new concept of “sociability space” (the geographical portion of the activity space consisting of places visited with social network member). Sociability places are found to less numerous, less diversified, more spatially dispersed and more decentered from residence than non-sociability places. Regarding traditional social network measures (degree, global clustering, etc.), stronger and more numerous correlations are observed with the structural characteristics of sociability spaces than with non-sociability spaces. Finally, variations in structural characteristics of sociability spaces according to people’s socio-demographic and residential profiles largely differ from those observed in structural characteristics of non-sociability spaces. This empirical study shows that “sociability space” indicators are complementary to social network indicators and provide a more precise picture of geography of social interactions than activity space considered as a whole. Such approach may help to identify particular groups at risk of social isolation, such as people living alone and those with a low level of education, and inspire public policies aiming at both promoting daily mobility and reducing social isolation.

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Fichiers liés : Fancello_et-al_The sociability space_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2026
• Auteurs : Rita BitarPhilippe BlumsteinNicolas SoetartPierre CordierMaria Dolores SanchezBienvenue RazafimandimbyFaraj FajlounJean-Philippe BoucharaJacques GuillotEmmanuel Bensignor
• Organismes : SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique
• Publié dans Journal of Medical Mycology = Journal de Mycologie Médicale le 31/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/05/2026
• Auteurs : Julien RouzotChristian ArtiguesClement CarbonnelPhilippe GarnierEmmanuel HebrardPierre LopezBertrand Simon
• Organismes : Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Agents, Apprentissage, Contraintes Institut de recherche en astrophysique et planétologie Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Laboratoire d'Informatique de Grenoble Université Grenoble Alpes Institut polytechnique de Grenoble - Grenoble Institute of Technology

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Résumé : In space missions, scientific data collected by various instruments must be stored onboard before being downlinked to Earth during designated communication windows. For many long range missions, the available bandwidth is shared according to a priority assigned to each memory buffer during such downlink window. The overlapping Memory Dumping Problem (oMDP) consists in finding the priority assignment that minimizes the highest memory peak. This problem has been shown to be weakly NP-hard and has so far only been addressed with heuristic methods. In this paper, we complete the complexity analysis by proving that the problem is strongly NP-hard in the general case, and we propose the first exact method to solve the oMDP. We present a constraint programming approach combining new global constraints and a heuristic branching strategy, and show that our method is competitive with state-of-the-art heuristics while being more generic and able to produce optimality proofs on small instances.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2026
• Auteurs : Caroline RobertEmilie GérardEmilie LanoyGaelle QuéreuxPhilippe BernardManuelle ViguierFlorent GrangeNicolas MeyerMonica DinulescuDelphine LegoupilEve Marie NeidhardtPhilippe SaiagSabiha TrabelsiPhilippe CélérierCharlee NardinEve MaubecAnne-Benedicte Duval- ModesteEwa HainautSophie DarrasHerve MaillardSarah GueganJean-Philippe ArnaultPierre-Emmanuel StoebnerYannick Le CorreLucie PeuvrelBertille BonniaudHugo HerrscherFlorence Granel-BrocardAnne-Lise VataireAurore TabellionCeleste LebbéLaurent Mortier
• Organismes : Université Paris-Saclay Département de médecine oncologique [Gustave Roussy] Hôpital Saint-André CIC - HEGP Immunology and New Concepts in ImmunoTherapy Centre Hospitalier Universitaire Dupuytren 1 et 2 Hôpital Robert Debré Centre hospitalier de Valence Clinique Médipôle Garonne CRLCC Eugène Marquis Hôpital Morvan [Brest] Centre Léon Bérard [Lyon] Hôpital Ambroise Paré [AP-HP] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Hôpital Avicenne [AP-HP] CHU Rouen Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Le Mans (CH Le Mans) Paris Santé Cochin CHU Amiens-Picardie Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Universitaire d'Angers Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Groupe Hospitalier Saint-Vincent Centre Hospitalier Régional Universitaire de Nancy Sanofi Winthrop Industry [Paris] Sanofi Winthrop Industry [Paris] Immunologie humaine, physiopathologie & immunothérapie Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : Background: Cemiplimab an anti-programmed cell death receptor-1 antibody, was approved by the FDA and EMA for patients with locally advanced cutaneous squamous cell carcinoma (laCSCC) ineligible for curative surgery/radiotherapy or with metastatic (m) CSCC. TOSCA study evaluated the real-world effectiveness and safety of cemiplimab compared to historical systemic therapies (HSTs). Methods: TOSCA (NCT05302297) was a large French retrospective, multicenter study comparing patient with la/mCSCC treated with cemiplimab via the early access program (EAP, 2018-2019) or HST (2013-2018). The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS), duration of response (DoR), overall response rate (ORR), and safety. Effectiveness analysis using inverse probability weighting included a trial-like cohort of only immunocompetent patients meeting the EAP criteria to emulate a randomized clinical trial; safety analysis included all real-life patients. Findings: The study included 280 real-life patients (cemiplimab: n = 147; HST: n = 133). The primary effectiveness analysis included a trial-like cohort (cemiplimab: n = 129; HST: n = 70; median age: 81 and 78 years, respectively). Median follow-up was 20 and 10 months in the cemiplimab and HST arms, respectively; median OS was 21.2 and 9.8 months, respectively (HR 95% CI: 0.57 [0.45-0.73]; P < 0.0001); median PFS was 13.7 and 5.3 months, respectively (HR [95% CI]: 0.57 [0.43-0.76]; P = 0.0001). Adverse drug reactions occurred in 27% of cemiplimab patients and 33% of HST patients. Interpretation: TOSCA demonstrated better survival and response outcomes for cemiplimab versus HST in la/mCSCC; emphasizing, the importance of this retrospective studie in the absence of standard comparative trials.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2026
• Auteurs : Tim RietbergSusana BarbosaPieter MeysmanBruno AouizerateFrank BellivierFabrice BernaDelphine CapdevielleIsabelle Chereau-BoudetPhilippe CourtetClément DondéCaroline DubertretB EtainWissam El-HageMona GerentesJérôme HoltzmannEric FakraEmmanuel HaffenNoomane BouazizAntoine LefrerePierre-Michel LlorcaJasmina MalletDavid MisdrahiÉmilie OliéAgnès PelletierGiulia PivaBaptiste PignonMircea PolosanRomain ReyPaul RouxLudovic SamalinFranck SchürhoffRaymund SchwanFlorian StéphanDavid SzekelyMathieu UrbachGuillaume VaivaEtienne VeryAntoine YrondiMarion LeboyerLivia de PickerOphélia Godin
• Organismes : Universiteit Antwerpen = University of Antwerp Equipe Sociale Santé Mentale et Addictions [iPLesp] Sorbonne Université Universiteit Antwerpen = University of Antwerp Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpitaux Universitaires de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Neuroscience et Psychiatrie Translationnelle de Strasbourg Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Université Clermont Auvergne Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes Isère [Grenoble, France] Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Imaging, Brain & Neuropsychiatry Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Fondation FondaMental [Créteil] Pôle Psychiatrie [CHU Saint-Etienne] Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Université Marie et Louis Pasteur Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Université Sorbonne Paris Nord Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Assistance Publique - Hôpitaux de Marseille Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Laboratoire Interdisciplinaire pour l'Innovation et la Recherche en Santé d’Orléans Centre Hospitalier Universitaire d'Orléans Fondation FondaMental [Créteil] Etablissement public de santé mentale du Loiret Georges Daumézon Université de Bordeaux Fondation FondaMental [Créteil] Institut de Neurosciences cognitives et intégratives d'Aquitaine Centre hospitalier Charles Perrens [Bordeaux] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 Fondation FondaMental [Créteil] Hôpital Henri Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes Isère [Grenoble, France] Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Fondation FondaMental [Créteil] Université Paris-Est Créteil Val-de-Marne - Paris 12 Hôpital Henri Mondor IMRB - "NeuroPsychologie Interventionnelle" [Créteil] Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] CHRU Brest - Psychiatrie Adulte Hôpital Princesse Grace [Monaco] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] Centre National de Ressources et de Résilience [Lille] Fondation FondaMental [Créteil] Service Psychiatrie, Psychothérapies et Art-thérapie [CHU Toulouse] Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Toulouse NeuroImaging Center Service Psychiatrie et psychologie médicale [CHU Toulouse] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] Hôpital Henri Mondor Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Universiteit Antwerpen = University of Antwerp Fondation FondaMental [Créteil] Hôpital Henri Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
• Publié dans Brain, Behavior, and Immunity le 29/10/2020

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Résumé : Background and objectives: Low-grade systemic inflammation contributes to the pathophysiology of severe mental illness (SMI) in a substantial subset of patients, who often experience greater disease burden and poorer treatment response. Elevated C-reactive protein (CRP), defined as CRP ≥ 3 mg/L, has been proposed to identify this group, but its non-specificity limits the biomarker's ability to guide targeted intervention. We aimed to determine the most consistent drivers of high CRP across bipolar disorder (BD), schizophrenia (SZ) and major depressive disorder (MDD), and to translate these into clinically actionable intervention targets using robust data-driven methods. Methods: We pooled and harmonised data from three large French national SMI cohorts (n = 7149: 4797 bipolar disorder, 1958 schizophrenia and 394 resistant major depression) and classified participants by CRP ≥ 3 mg/L, as well as an alternative cut-off of 5 mg/L. We applied penalised logistic regression (PLR), random forests (RF) and unsupervised clustering, using 28 biopsychosocial variables to identify robust drivers of high-CRP status. We then grouped these into actionable targets and assessed relative dominance. Results: In total, 30.16% of participants had CRP ≥ 3 mg/L. PLR identified female sex (OR [95% CI]: 1.60 [1.27, 1.93]), higher BMI (OR: 1.09 [1.07, 1.13]), current nicotine dependence (OR: 1.05 [1.02, 1.09]), lower HDL cholesterol (OR: 0.57 [0.44, 0.73]) and smoking (ex-smoker status OR: 0.84 [0.66, 0.98]) as consistent drivers. RF highlighted a similar set of key drivers, also including waist circumference, triglycerides and cardiovascular comorbidities. Clustering of the high-CRP group was almost entirely driven by smoking status and nicotine dependence. When grouped into actionable targets, the identified drivers accounted for 16% of variance in CRP status, with obesity emerging as most dominant contributor. This pattern was most pronounced in females; in males it was more diffuse, with a more prominent role for smoking. Conclusions: We propose a decision tree framework where CRP can serve as a first-line screening marker for inflammation in SMI, with subsequent steps focusing on the main contributing factors to guide targeted interventions. Priority should be given to targeting obesity and metabolic dysregulation. Among females, hyperuricemia represents the next most appropriate target, whereas in males, smoking warrants greater attention. This stepwise approach provides a route from a nonspecific biomarker to targeted treatment strategies and should be validated in prospective studies.

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Fichiers liés : 1-s2.0-S0889159126002126-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/04/2026
• Auteurs : Maxime SchleefValentin MayetAmélie Le GougeJulio BadieLouis ChauvelotJérôme DevaquetSamir JaberJulien JabotFabien LambiotteBenjamin MadeuxClara VigneronDidier ThéveninSaad NseirGaetan PlantefeveJean-Pierre QuenotJean-Philippe RigaudJean-Etienne HerbrechtBertrand SouweinePatrice TirotIsabelle VinatierJean ReignierLaurent ArgaudJean-Baptiste LascarrouDiane MaugarsGaëtan PlantefèveDamien ContouOlivier PajotCécile Le ParcoJean-Paul MiraPaul JaubertNathalie MarinLaurent ArgaudMartin CourNeven StevicMarion ProventPierre AsfarSatar MortazaMarc PierrotVincent SoudayMarie LemerleNadia AissaouiJulio BadieSylvain MalfroyFernando Berdaguer FerrariNicolae-Vlad BotocLaurent BrisardBertrand RozecLaurence PacaudHoang-Nam BuiDidier GrusonCharline SazioSuzanne ChampionRémi CoudroyFlorence BoissierAnne VeinsteinLouis ChauvelotLoredana BaboiJean-Christophe RichardHodane YonisAlain CombesLoïc Le GuennecLucie LefevreJuliette ChommelouxGuillaume HékimianMichael DarmonVirginie LemialeEric MariotteSandrine ValadeVincent DasJoanna TirolienMatthieu DebarreAgathe DelboveYannick FedunSébastien BigotJerôme DevaquetCharles CerfGuillaume TachonLouis-Marie DumontOlivier GontierSamuel GroyerJérôme RoustanSylvie VimeuxMichel BonnivardLaurent GuérinNadia AnguelDavid OsmanBertrand GuidetYannick HourmantKarim AsehnouneAntoine RoquillyFouad BelafiaMatthieu ConseilMoussa CisseLambiotte FabienBouras ChaoukiFodil HannaneChristophe LeroyAnthéa LoïezRémi EspenelMargot ChabanonPhilippe LetocartChristine BrasseSebastien EnaArnaud DelahayeJeremy CastaneraThiery DulacPhilippe PetuaJulien MaizelYoann ZerbibClement BraultOlivier MartinetFrédéric MartinoRégine RichardDjillali AnnaneRania BounabNicholas HemingVirginie MaximeEmmanuelle MercierMai-Anh NayThierry BoulainSophie JacquierGrégoire MullerSaad NseirRaphaël FavorySébastien PreauJulien PoissyJohanna OzielAlexandre MassriFloriane LissondeMarie VaissiereGaël PitonHadrien WiniszewskiThibault VieilleJean-Pierre QuenotMarine JacquierMarie LabruyèrePascal AndreuFlorian ReizineJean-Marc TadiéAnne RenaultLaetitia BodenesJack RichecoeurDanièle CombauxDavid LuisFabienne HuysmanJean-Philippe RigaudAntoine MarchalotCécile LafosseChristelle BigotFrançis SchneiderRaphaël Clere-JehlChristophe CraccoDavid SchnellDaniel SilvaJérôme AboadMichel SirodotDavid BougonEtienne EscudierMarion LeboucElisabeth CoupezClaire DupuisFabienne TamionGregoire JollyZoé DemaillyNicolas TerziLouis-Marie GalerneauAmel RefesPierre NicolasOlivier NigeonGuillaume ThiéryNathalie Thieulot-RolinJonathan ChellyFranck PourcineLy Van VongJean-François TimsitSonia AbidÉtienne de MontmollinRomain SonnevilleFrançois TinturierChristophe GuittonNicolas ChudeauMickaël LandaisThierry VanderlindenVincent PagesIsabelle VinatierAngélique DeschampsNatacha MaquigneauChristophe VinsonneauCaroline SejourneImen RahmaniGhada SbouiSebastian VoicuBruno MégarbaneNicolas DeyeIsabelle Malissin
• Organismes : Cardiovasculaire, métabolisme, diabétologie et nutrition Hospices Civils de Lyon Université Claude Bernard Lyon 1 Hôpital Edouard Herriot [CHU - HCL] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre de recherche en éducation de Nantes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance
• Publié dans Intensive Care Medicine le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2026
• Auteurs : Paul VerweijAna Alastruey-IzquierdoKarin AmilonMaiken Cavling ArendrupDarius Armstrong-JamesElaine BignellDavid R BoulwareJoão BrandãoMike BromleyGordon BrownJochem BuilArunaloke ChakrabartiMethee ChayakulkeereeTom ChillerAriya ChindampornArnaldo ColomboOliver CornelyEric DannaouiPhilippe DufresneAgustina ForastieroJean-Pierre GangneuxChristian GiskeNelesh GovenderNeil GowJacques GuillotThomas HarrisonMartin HoeniglDimitrios KontoyiannisCornelia Lass-FlörlThuy LeRuoyu LiNarda MedinaJacques MeisJoseph MeletiadisRita OladeleLuis Ostrosky-ZeichnerAtul PatelJohn PerfectFlavio Queiroz-TellesJuan Luis Rodriguez-TudelaShivaprakash RudramurthyJon Salmanton GarcíaAmanda Ribeiro dos SantosEsther SegalAmir SeyedmousaviYinggai SongGeorge ThompsonAntonio VenaAdilia WarrisNathan P WiederholdMichaela LacknerAmanda Ribeiro dos SantosAtul PatelPaul VerweijJon Salmanton GarcíaMaiken Cavling Arendrup
• Organismes : Unité de Parasitologie-Mycologie [CHU HEGP] Université Paris Cité Dynamic Microbiology - EA 7380 Archéosciences Bordeaux Géosciences Rennes Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique
• Publié dans Nature Medicine le 29/10/2020

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 14/04/2026
• Auteurs : Abdourahmane KhontéDiégane SarrPape Abdoulaye DiawDiène Diégane ThiaréJean Pierre BakhoumNdeye Arame DiopAtanasse ColyPhilippe Giamarchi
• Organismes : Université Alioune Diop de Bambey Université Alioune Diop de Bambey Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Université Cheikh Anta Diop de Dakar [Sénégal] Laboratoire d'Optique et de Magnétisme

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Résumé : Serotonin, like many small organic molecules, can undergo photochemical transformations under UV irradiation. Photodegradation of pharmaceuticals and biologically active compounds is an active research field due to concerns about drug stability under light exposure and the environmental fate of pharmaceutical residues in water systems. This study investigates the photophysical and photochemical behaviour of serotonin (5-HT) in various environments, including aqueous, organic, and micellar media. Using UV–vis absorption and fluorescence spectroscopy, key parameters such as dipole moments, Stokes shifts, and fluorescence lifetimes were determined. Solvatochromic analysis was performed with Lippert-Mataga, Bakhshiev, and related models, revealing significant intramolecular charge redistribution upon excitation (dipole moment increase to ~7.8 D). Photolysis kinetics were studied under controlled conditions, showing first- and second-order behaviours depending on the medium. Half-lives ranged from 24 s in aqueous pH 7 solutions to over 1900 s in micellar systems, illustrating enhanced photostability in hydrophobic microenvironments. The localisation of serotonin at the micelle–water interface was identified as a key factor governing its photochemical response. Quantitative data are summarised in tables for spectroscopic parameters, dipole moments, and kinetic constants, providing clarity and reproducibility. The findings offer insights into the influence of solvent polarity, pH, and micellar structures on serotonin’s stability and reactivity, with implications for neurochemistry, pharmacology, and photobiology. Overall, this comprehensive study demonstrates the utility of spectrofluorimetric methods in evaluating biomolecular photostability and provides a framework for designing safer drug formulations sensitive to light.

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• Type de publi. : Article dans une revue
• Date de publi. : 09/04/2026
• Auteurs : Dunya AlraddawiPhilippe KeckhutFlorian MandijaAlexis MariacciaChristophe PietrasJean-Charles DupontGuillaume PayenHélène VérèmesAlain HauchecorneAlain SarkissianJean-François MariscalJacques PorteneuveJean-Luc BarayNadège MontouxPatrick FrévilleSergey Khaykin
• Organismes : ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS Laboratoire de Météorologie Dynamique (UMR 8539) Institut Pierre-Simon-Laplace Université de La Réunion Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS Gordien Strato Laboratoire de Météorologie Physique Laboratoire de Météorologie Physique Observatoire de Physique du Globe de Clermont-Ferrand Laboratoire de Météorologie Physique Observatoire de Physique du Globe de Clermont-Ferrand ATMOSPHERE - LATMOS
• Publié dans EPJ Web of Conferences le 23/10/2020

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Résumé : Accurate water vapor measurements in the upper troposphere at cruise altitude are required to investigate contrails formation. We present 4 Raman lidars having these capabilities in France. Water vapor mixing ratio is proportional to the ratio of H2O and N2 Raman signals for the same altitude by a scale factor called calibration factor. Coaxial systems can be calibrated with independent measurement of water vapor total column. A more universal external method able to calibrate any lidar (co/non-axial system) is adopted, using co-located ERA5 hourly water vapor profiles. Full night calibration factor is estimated as the mean of hourly coefficients, daily calibrations are inspected to detect any instrumental changes. Final coefficients are then considered for quasi stationary periods. Calibrated profiles are validated against available radiosondes ones. This new software can be used to force models to better understand contrails contribution in future air traffic regulation as part of European project BeCoM.

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Fichiers liés : epjconf_clrc-ilrc2026_09011.pdf

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