Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Jade RoyoBertin VianouManfred AccrombessiElisée KinkpéLinda AyédadjouIda Dossou-DagbaYélé LadipoMaroufou Jules AlaoGwladys BertinMichel CotFarid BoumédièneSandrine HouzéJean François FaucherAgnès AubouyDissou AffolabiDaniel AjzenbergBibiane BiokouJosselin BrissetJean-Eudes DegbeloPhilippe DeloronLatifou DramaneSayeh Jafari-GuemouriClaire KamaliddinAnaïs LabrunieThomas LathiereAchille MassougbodjiAudrey MowendabekaJade PapinBernard PipyPierre-Marie PreuxMarie RaymondeauDarius SossouBrigitte TecherLaurence Watier
• Organismes : Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Infectious Diseases of Poverty le 27/10/2020

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Résumé : Abstract Background Cerebral malaria (CM) is a neuropathology which remains one of the deadliest forms of malaria among African children. The kinetics of the pathophysiological mechanisms leading to neuroinflammation and the death or survival of patients during CM are still poorly understood. The increasing production of cytokines, chemokines and other actors of the inflammatory and oxidative response by various local actors in response to neuroinflammation plays a major role during CM, participating in both the amplification of the neuroinflammation phenomenon and its resolution. In this study, we aimed to identify risk factors for CM death among specific variables of inflammatory and oxidative responses to improve our understanding of CM pathogenesis. Methods Children presenting with CM ( n = 70) due to P. falciparum infection were included in southern Benin and divided according to the clinical outcome into 50 children who survived and 20 who died. Clinical examination was complemented by fundoscopic examination and extensive blood biochemical analysis associated with molecular diagnosis by multiplex PCR targeting 14 pathogens in the patients’ cerebrospinal fluid to rule out coinfections. Luminex technology and enzyme immunoassay kits were used to measure 17 plasma and 7 urinary biomarker levels, respectively. Data were analysed by univariate analysis using the nonparametric Mann‒Whitney U test and Pearson’s Chi2 test. Adjusted and multivariate analyses were conducted separately for plasma and urinary biomarkers to identify CM mortality risk factors. Results Univariate analysis revealed higher plasma levels of tumour necrosis factor (TNF), interleukin-1beta (IL-1β), IL-10, IL-8, C-X-C motif chemokine ligand 9 (CXCL9), granzyme B, and angiopoietin-2 and lower urinary levels of prostanglandine E2 metabolite (PGEM) in children who died compared to those who survived CM (Mann–Whitney U -test, P -values between 0.03 and < 0.0001). The multivariate logistic analysis highlighted elevated plasma levels of IL-8 as the main risk factor for death during CM (adjusted odd ratio = 14.2, P -value = 0.002). Values obtained during follow-up at D3 and D30 revealed immune factors associated with disease resolution, including plasma CXCL5, C–C motif chemokine ligand 17 (CCL17), CCL22, and urinary 15-F2t-isoprostane. Conclusions The main risk factor of death during CM was thus elevated plasma levels of IL-8 at inclusion. Follow-up of patients until D30 revealed marker profiles of disease aggravation and resolution for markers implicated in neutrophil activation, endothelium activation and damage, inflammatory and oxidative response. These results provide important insight into our understanding of CM pathogenesis and clinical outcome and may have important therapeutic implications. Graphical Abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : William YoungJeffrey HaesslerJan-Walter BenjaminsLinda RepettoJie YaoAaron IsaacsAndrew HarperJulia RamirezSophie GarnierStefan van DuijvenbodenAntoine BaldassariMaria Pina ConcasThuyvy DuongLuisa FocoJonas IsaksenHao MeiRaymond NoordamCasia NursyifaAnne RichmondMeddly SantolallaColleen SitlaniNegin SoroushSébastien ThériaultStella TrompetStefanie AeschbacherFariba AhmadizarAlvaro AlonsoJennifer BrodyArchie CampbellAdolfo CorreaDawood DarbarAntonio de LucaJean-François DeleuzeChristina EllervikChristian FuchsbergerAnuj GoelChristopher GraceXiuqing GuoTorben HansenSusan HeckbertRebecca JacksonJan KorsMaria Fernanda Lima-CostaAllan LinnebergPeter MacfarlaneAlanna MorrisonPau NavarroDavid PorteousPeter PramstallerAlexander ReinerLorenz RischUlrich SchottenXia ShenGianfranco SinagraElsayed SolimanMonika StollEduardo Tarazona-SantosAndrew TinkerKaterina TrajanoskaEric VillardHelen WarrenEric WhitselKerri WigginsDan ArkingChristy AveryDavid ConenGiorgia GirottoNiels GrarupCaroline HaywardJ.Wouter JukemaDennis Mook-KanamoriMorten Salling OlesenSandosh PadmanabhanBruce PsatyCristian PattaroAntonio Luiz P. RibeiroJerome RotterBruno StrickerPim van der HarstCornelia van DuijnNiek VerweijJames WilsonMichele OriniPhilippe CharronHugh WatkinsCharles KooperbergHenry LinJames WilsonJørgen KantersNona SotoodehniaBorbala MifsudPier LambiaseLarisa TereshchenkoPatricia Munroe
• Organismes : Cardiovascular Genomics Cardiovascular Genomics Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Pitié-Salpêtrière [AP-HP] Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires ou Rares [Boulogne-Billancourt] Sorbonne Université Hôpital Ambroise Paré [AP-HP]
• Publié dans Nature Communications le 23/10/2020

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Résumé : Abstract The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle ( N = 118,780) and 11 for the frontal QRS-T angle ( N = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Emmanuel PardoThomas LescotJean-Charles PreiserPablo MassanetAntoine PonsSamir JaberVincent FraipontEric LevesqueCarole IchaiLaurent PetitFabienne TamionGarry TavernyPriscilla BoizeauCorinne AlbertiJean-Michel ConstantinMarie-Pierre BonnetDésiré SambaJean-Denis MoyerPhilippe MontraversNicolas MongardonArnaud MeffertAudrey de JongFouad BelafiaJérome MorelKarim AsehnounePierre-Joachim MahéAlain D’hondtNicolas PaquotMarc LeoneMichel KaidomarLudovic GrechEliane GouteixElise BarsamJacques DuranteauOrianne MartinezAudrey de Jong
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Current guidelines suggest the introduction of early nutrition support within the first 48 h of admission to the intensive care unit (ICU) for patients who cannot eat. In that context, we aimed to describe nutrition practices in the ICU and study the association between the introduction of early nutrition support (< 48 h) in the ICU and patient mortality at day 28 (D28) using data from a multicentre prospective cohort. Methods The ‘French-Speaking ICU Nutritional Survey’ (FRANS) study was conducted in 26 ICUs in France and Belgium over 3 months in 2015. Adult patients with a predicted ICU length of stay > 3 days were consecutively included and followed for 10 days. Their mortality was assessed at D28. We investigated the association between early nutrition (< 48 h) and mortality at D28 using univariate and multivariate propensity-score-weighted logistic regression analyses. Results During the study period, 1206 patients were included. Early nutrition support was administered to 718 patients (59.5%), with 504 patients receiving enteral nutrition and 214 parenteral nutrition. Early nutrition was more frequently prescribed in the presence of multiple organ failure and less frequently in overweight and obese patients. Early nutrition was significantly associated with D28 mortality in the univariate analysis (crude odds ratio (OR) 1.69, 95% confidence interval (CI) 1.23–2.34) and propensity-weighted multivariate analysis (adjusted OR (aOR) 1.05, 95% CI 1.00–1.10). In subgroup analyses, this association was stronger in patients ≤ 65 years and with SOFA scores ≤ 8. Compared with no early nutrition, a significant association was found of D28 mortality with early enteral (aOR 1.06, 95% CI 1.01–1.11) but not early parenteral nutrition (aOR 1.04, 95% CI 0.98–1.11). Conclusions In this prospective cohort study, early nutrition support in the ICU was significantly associated with increased mortality at D28, particularly in younger patients with less severe disease. Compared to no early nutrition, only early enteral nutrition appeared to be associated with increased mortality. Such findings are in contrast with current guidelines on the provision of early nutrition support in the ICU and may challenge our current practices, particularly concerning patients at low nutrition risk. Trial registration ClinicalTrials.gov Identifier: NCT02599948. Retrospectively registered on November 5th 2015.

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Fichiers liés : 2023 Pardo et al., Association between early nutrition support and 28.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/06/2023
• Auteurs : Constance DouwesGiovanni BindiAntoine CaillonPhilippe EslingJean-Pierre Briot
• Organismes : Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son BAYER AG Sciences et Technologies de la Musique et du Son Systèmes Multi-Agents

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Résumé : In most scientific domains, the deep learning community has largely focused on the quality of deep generative models, resulting in highly accurate and successful solutions. However, this race for quality comes at a tremendous computational cost, which incurs vast energy consumption and greenhouse gas emissions. At the heart of this problem are the measures that we use as a scientific community to evaluate our work. In this paper, we suggest relying on a multi-objective measure based on Pareto optimality, which takes into account both the quality of the model and its energy consumption. By applying our measure on the current state-of-the-art in generative audio models, we show that it can drastically change the significance of the results. We believe that this type of metric can be widely used by the community to evaluate their work, while putting computational cost – and in fine energy consumption – in the spotlight of deep learning research.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2023
• Auteurs : Cyrille FérayLoïc CampionPhilippe MathurinIsabelle ArchambreaudXavier MirabelJean Pierre BronowickiEmmanuel RioChristophe PerretLaurent MineurFrédéric ObertiYann TouchefeuJérôme GournayHélène RegnaultJulien EdelineAgnès RodePatrick HillionJean Frédéric BlancEric Nguyen-KhacDaniel AzoulayAlain LucianiAthena Galetto PreglisascoElodie Faurel-PaulHélène AubleFrançoise MornexPhilippe Merle
• Organismes : Physiopathologie et traitement des maladies du foie Institut de Cancérologie de l'Ouest [Angers/Nantes] Service des Maladies de l'Appareil Digestif et de la Nutrition [CHRU Lille] Institute for Translational Research in Inflammation - U 1286 Centre hospitalier universitaire de Nantes Institut des Maladies de l'Appareil Digestif Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Nutrition-Génétique et Exposition aux Risques Environnementaux Service d'Hépato-gastro-entérologie [CHRU Nancy] Institut de Cancérologie de l'Ouest [Angers/Nantes] Hôtel-Dieu de Nantes Institut Sainte Catherine [Avignon] Centre Hospitalier Universitaire d'Angers Centre hospitalier universitaire de Nantes Centre hospitalier universitaire de Nantes Institut des Maladies de l'Appareil Digestif Service d'hépato-gastro-entérologie [APHP Henri Mondor] Oncogenesis, Stress, Signaling Service de Radiologie [Hôpital de la Croix-Rousse - HCL] Service d'Hépato-Gastro-Entérologie (CHU de Dijon) Hôpital Haut-Lévêque [CHU Bordeaux] Bordeaux Research In Translational Oncology [Bordeaux] CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 Physiopathologie et traitement des maladies du foie Service de Radiologie [Mondor] Service de Radiologie [Mondor] Hôtel-Dieu de Nantes Hôtel-Dieu de Nantes Centre pour l'innovation en cancérologie de Lyon Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL] Centre de Recherche en Cancérologie de Lyon Service d'Hépatologie et de Gastroentérologie [Lyon]
• Publié dans JHEP Reports Innovation in Hepatology le 07/09/2020

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Résumé : Background & aims: Transcatheter arterial chemoembolisation (TACE) is recommended for patients with hepatocellular carcinoma devoid of macrovascular invasion or extrahepatic spread but not eligible for curative therapies. We compared the efficacy and safety of the combination of a single TACE and external conformal radiotherapy (CRT) vs. classical TACE. Methods: TACERTE was an open-labelled, randomised controlled trial with a 1:1 allocation rate to two or three TACE (arm A) or one TACE + CRT (arm B). Participants had a mean age of 70 years, and 86% were male. The aetiology was alcohol in 85%. The primary endpoint was liver progression-free survival (PFS) in the intention-to-treat population. The typical CRT schedule was 54 Gy in 18 sessions of 3 Gy. Results: Of the 120 participants randomised, 64 were in arm A and 56 in arm B; 100 participants underwent the planned schedule and defined the 'per-protocol' group. In intention-to-treat participants, the liver PFS at 12 and 18 months were 59% and 19% in arm A and 61% and 36% in arm B (hazard ratio [HR] 0.69; 95% CI 0.40-1.18; p = 0.17), respectively. In the per-protocol population, treated liver PFS tended to be better in arm B (HR 0.61; 95% CI 0.34-1.06; p = 0.081) than in arm A. Liver-related grade III-IV adverse events were more frequent in arm B than in arm A. Median overall survival reached 30 months (95% CI 23-35) in arm A and 22 months (95% CI 15.7-26.2) in arm B. Conclusions: Although TACE + CRT tended to improve local control, this first Western randomised controlled trial showed that the combined strategy failed to increase PFS or overall survival and led more frequently to liver-related adverse effects. Impact and implications: Hepatocellular carcinoma is frequently treated by arterial embolisation of the tumour and more recently by external radiotherapy. We tried to determine whether combination of the two treatments (irradiation after embolisation) might produce interesting results. Our results in this prospective randomised study were not able to demonstrate a beneficial effect of combining embolisation and irradiation in these patients. On the contrary, we observed more adverse effects with the combined treatment.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2023
• Auteurs : Perrine RoussetStéphane DalleLaurent MortierOlivier DereureSophie DalacCaroline DutriauxMarie-Thérèse LecciaDelphine LegoupilFlorence Brunet-PossentiJulie de QuatrebarbesJean-Jacques GrobPhilippe SaiagEve MaubecPierre-Emmanuel StoebnerFlorence Granel-BrocardJean-Philippe ArnaultClara AllayousBastien OrianoCeleste LebbéHenri Montaudié
• Organismes : Centre Hospitalier Universitaire de Nice Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Thérapies Laser Assistées par l'Image pour l'Oncologie - U 1189 Centre Hospitalier Régional Universitaire [Lille] Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Régional Universitaire [Montpellier] Service de Dermatologie (CHU de Dijon) CHU Bordeaux [Bordeaux] Centre Hospitalier Universitaire [Grenoble] Centre Hospitalier Régional Universitaire de Brest AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Service de dermatologie, vénéreologie et cancérologie cutanée [Hôpital de la Timone - APHM] Hôpital Ambroise Paré [AP-HP] Université de Versailles Saint-Quentin-en-Yvelines Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Hôpital Avicenne [AP-HP] Centre Hospitalier Universitaire de Nîmes Institut de Recherche en Cancérologie de Montpellier Service de Dermatologie et Allergologie [CHRU Nancy] CHU Amiens-Picardie Service de Dermatologie [AP-HP Hôpital Saint-Louis] Immunologie humaine, physiopathologie & immunothérapie Hopital Saint-Louis [AP-HP] Hôpital Hôtel-Dieu [Paris] Assistance publique - Hôpitaux de Paris (AP-HP) Service de Dermatologie [Nice] Centre méditerranéen de médecine moléculaire
• Publié dans Journal of The American Academy of Dermatology le 26/10/2020

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Résumé : Background: Clinical outcomes of advanced melanoma of unknown primary (MUP) in the era of novel therapies have been scarcely studied. Objective: To investigate the efficacy and safety of systemic treatments in patients with advanced MUP compared to patients with stage-matched melanoma of known cutaneous primary (cMKP). Methods: Based on the nationwide MelBase prospective database, this study included advanced melanoma patients treated from March 2013 to June 2021 with first-line immunotherapies, targeted therapies, or chemotherapy. Co-primary outcomes were progression-free survival and overall survival. Secondary outcome was treatment-related toxicities. Multivariate and propensity score analyses were performed. Results: Of 1882 patients, 265 (14.1%) had advanced MUP. Patients with advanced MUP displayed more often unfavorable initial prognostic factors than those with cMKP. Progression-free and overall survival did not differ significantly between the groups (P = .73 and P = .93, respectively), as well as treatment-related toxicity rate and severity, regardless of treatment type. Limitations: No record of standard diagnostic criteria of MUP used in the participating centers. Conclusions: Although patients with MUP had less favorable baseline prognostic factors, they benefited from the novel therapies as much as those with cMKP. They should be managed according to similar strategies.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 31/03/2023
• Auteurs : Georges AadBraden Keim AbbottKira AbelingNils Julius AbichtHaider AbidiAsmaa AboulhormaHalina AbramowiczHenso AbreuYiming AbulaitiAngel AbuslemeBobby Samir AcharyaClaire Adam BourdariosLeszek AdamczykLukas AdamekSagar AddepalliJahred AdelmanAytul AdiguzelSofia Adorni Braccesi ChiassiTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasJinky AgarwalaAnamika AggarwalCatalin AgheorghieseiAmmara AhmadFaig AhmadovWaleed Syed AhmedSudha AhujaXiaocong AiGiulio AielliMalak Ait TamlihatBrahim AitbenchikhIakov AizenbergMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarKonie Al KhouryGian Luigi AlberghiJustin AlbertPietro AlbicoccoGuillaume Lucas AlbouySara AlderweireldtMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosAlice AlfonsiFabrizio AlfonsiMuhammad AlhroobBabar AliShahzad AliMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeCristian Andres Allendes FloresPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiManuel Alvarez EstevezAdrian Alvarez FernandezMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesDante AmideiSusana Patricia Amor dos SantosKieran Robert AmosViktor AnanievChristos AnastopoulosTimothy Robert AndeenJohn Kenneth AndersStefio Yosse AndreanAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelMatthew Thomas AnthonyEgor AntipovMario AntonelliDaniel Joseph AntrimFabio AnulliMasato AokiTakumi AokiJavier Alberto Aparisi PozoMarco AparoLudovica Aperio BellaChristian AppeltNordin Aranzabal BarrioVictor Araujo FerrazChiara ArcangelettiAyana Tamu ArceEloisa ArenaJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingAaron James ArmbrusterOlivier ArnaezHannah ArnoldZulit Paola Arrubarrena TameGiacomo ArtoniHaruka AsadaKanae AsaiShoji AsaiNedaa Alexandra AsbahJihad AssahsahKetevi Adikle AssamaganRobert AstalosRose AtashiRyan Justin AtkinMarkus Julian AtkinsonNaim Bora AtlayHicham AtmaniPrachi AtmasiddhaKamil AugstenSilvia AuricchioAdrien AuriolVolker Andreas AustrupGiuseppe AvolioKonstantinos AxiotisGeorges AzuelosDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuKarl Filip BackmanAnthony BadeaPaolo BagnaiaMarzieh BahmaniAdam BaileyVirginia BaileyJohn BainesChristos BakalisKeith BakerEvelin BakosDebottam Bakshi GuptaRahul BalasubramanianEvgenii BaldinPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasJohannes BalzElzbieta BanasMarilena BandieramonteAnjishnu BandyopadhyayShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoGregory BarbourKevin Nicholas BarendsTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliGaetano BaroneAlan BarrJackson BarrLaura Barranco NavarroFernando Barreiro AlonsoJoao Barreiro Guimaraes da CostaUriel BarronMaura BarrosSergey BarsovFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosAlexander BasanMarta Baselga BacarditAhmed BassalatMatthew Joseph BassoCandice Ruth BassonRichard BatesSouad BatlamousRichard BatleyBinish BatoolMarco BattagliaDaariimaa BattulgaMatteo BauceMichael BauerPatrick BauerTomas BazzanoJames BeachamTristan BeauPierre-Hugues BeaucheminFabian BechererPhilip BechtleHans Peter BeckKathrin BeckerAndrew BeddallVadim BednyakovChris BeeLars BeemsterThomas BeermannMarcia BegalliMichael BegelArabinda BeheraJanna Katharina BehrJoshua Falco BeirerFlorian BeisiegelMohamed BelfkirGideon BellaLorenzo BellagambaAlain BellerivePanagiotis BellosKonstantin BeloborodovNikita BelyaevDriss BenchekrounFatima BendebbaYan BenhammouMathieu BenoitJim BensingerStan BentvelsenLydia Audrey BeresfordMatteo Mario BerettaElin Bergeaas KuutmannNicolas BergerBenedikt Ludwig BergmannJuerg BeringerSimon BerlendisGregorio BernardiCatrin BerniusFlorian Urs BernlochnerFlorent BernonTracey BerryPeter BertaAnne-Sophie BertholdIain BertramSiegfried BethkeAlessandra BettiAdrian BevanMuaaz BhamjeeSomadutta BhattaDeb Sankar BhattacharyaPrajita BhattaraiVallary Shashikant BhopatkarRan BiRiccardo Maria BianchiGianluca BiancoOtmar BiebelRafal BielskiMichela BigliettiThomas BilloudMarcello BindiAhmet BingulCesare BiniAlessandro BiondiniCallum Jacob Birch-SykesGareth Adam BirdMattias BirmanMarek BirosTobias BisanzEmanuele BisceglieDiptaparna BiswasAlexander BitadzeKristian BjoerkeIngo BlochCraig BlockerAndrew James BlueUlla BlumenscheinJulian BlumenthalGerjan BobbinkViktor BobrovnikovMichael BoehlerBurkhard BohmDanijela BogavacAlexander BogdanchikovChristian BohmVeronique BoisvertPetar BokanTomasz BoldMarco BombenMarcella BonaMaarten BoonekampCallum Dale BoothAlbert Gyorgy BorbelyIurii BordulevHanna Maria Borecka-BielskaLucas Santiago BorgnaGuennadi BorissovDaniela BortolettoDavide BoscheriniMartine Fernandez-BosmanJonathan BossioKhalil BouaoudaNaseem BouchharJoseph BoudreauEva Bouhova-ThackerDjamel Eddine BoumedieneRomain BouquetAntonio BoveiaJamie BoydDiallo BoyeIgor BoykoJuraj BracinikNihal BrahimiGerhard Immanuel BrandtOleg BrandtFrued Erik BrarenBenjamin Paul BrauJim BrauRoy Schimmel BrenerLydia BrennerRichard BrennerShikma BresslerDavid BrittonDaniel Andreas BritzgerIan BrockGustaaf BrooijmansWilliam King BrooksElizabeth BrostLeesa Marea BrownTim Lukas BrucklerPawel Bruckman de RenstromBen BruersDusan BrunckoAlessia BruniGraziano BruniMarco BruschiNello BruscinoTrygve BuanesQuentin BuatDaniel BuchinAndy BuckleyIoulian BudagovMagnar Kopangen BuggeOleg BulekovBrendon BullardSergey BurdinCarsten BurgardAngela Maria BurgerBlake Oliver BurghgraveOleksandr BurlayenkoJon BurrCharles BurtonJackson Carl BurzynskiElena Laura BuschVolker BuescherPeter John BusseyJohn Mark ButlerCraig Macleod ButtarJonathan ButterworthWill ButtingerCarlos Josue Buxo VazquezAlexey BuzykaevGrazia CabrasSusana Cabrera UrbanDavide CaforioHuacheng CaiYuchen CaiValentina CairoOrhan CakirNoemi CalacePaolo CalafiuraGiovanni CalderiniPhilippe CalfayanGiuseppe CalleaLuiz CalobaDavid CalvetSamuel CalvetThomas Philippe CalvetMilene CalvettiReina Coromoto Camacho ToroStefano CamardaDaniel Camarero MunozPaolo CamarriMaria Teresa CamerlingoDavid CameronClement CamincherMario CampanelliAlessandra CamplaniVincenzo CanaleAuriane CanesseMarc Bret CanoJosu Cantero GarciaYumeng CaoFrancesca CapocasaMarcella CapuaAntonio CarboneRoberto CardarelliJuan Carlos CardenasFabio CardilloTancredi CarliGiampaolo CarlinoJuan Ignacio CarlottoBen CarlsonEvan Michael CarlsonLeonardo CarminatiMaria CarnesaleSascha CaronEdson Carquin LopezSonia CarraGiuseppe CarrattaFernando Carrio ArgosJoseph CarterThomas Michael CarterPilar Casado LechugaAlbert Francis CashaMaximilian CasparEmma Grace CastigliaFlorencia Luciana CastilloLucia Castillo GarciaVictoria Castillo GimenezNuno CastroAndrea CatinaccioJames CatmoreViviana CavaliereNoemi CavalliVincenzo CavasinniYusuf Can CekmeceliogluEmre CelebiFederico CelliMartino Salomone CentonzeKarel CernyAugusto Santiago CerqueiraAlex CerriLucio CerritoFabio CeruttiBeatrice CervatoAlberto CervelliGianmario CesariniSerkant CetinZakaria ChadiDhiman ChakrabortyMikael ChalaJay ChanWai Yuen ChanJohn Derek ChapmanEmilien ChaponBakar ChargeishviliDave CharltonThomas Paul CharmanMeghranjana ChatterjeeChainika ChauhanSergei ChekanovSergey ChekulaevG ShelkovAndy ChenBoping ChenCharlie ChenHuirun ChenHucheng ChenJing ChenJiayi ChenMaggie ChenShion ChenShenjian ChenXiang ChenXin ChenYe ChenAlkaid ChengHok Chuen Tom ChengSanha CheongAlexander CheplakovEvgeniya CheremushkinaElizaveta CherepanovaRajaa Cherkaoui El MoursliElliott CheuKingman CheungLaurent ChevalierVitaliano ChiarellaGiorgio ChiarelliNemer ChieddeGabriele ChiodiniAndrew Stephen ChisholmAdrian ChitanMariam ChitishviliMihail ChizhovKyungeon ChoiArthur ChomontYuan-Tang ChouEdwin ChowTasnuva ChowdhuryLawrence Davou ChristopherMichael Kwok Lam ChuMing Chung ChuXiaotong ChuJiri ChudobaJanusz ChwastowskiDavide CieriKrzysztof CieslaVladimir CindroAlessandra CiocioFrancesco CirottoZvi CitronMauro CitterioDan Andrei CiubotaruBianca Monica CiunguAllan ClarkPhilip ClarkJose Manuel Clavijo ColumbieSavannah ClawsonChristophe ClementJoshua ClercxLuca ClissaYann CoadouMarina CobalAndrea CoccaroRicardo BarrueRafael Coelho Lopes de SaSimone CoelliHadar CohenArtur CoimbraBrian ColeJohann CollotPatricia Conde MuinoMatt ConnellSimon ConnellIan Allan ConnellyEimear Isobel ConroyFrancesco ConventiHarry CookeAmanda SarkarArtur Cordeiro Oudot ChoiFelix CormierLouie Dartmoor CorpeMassimo CorradiFrancois CorriveauArely Cortes GonzalezMaria Jose Costa MezquitaFrancesco CostanzaDavide CostanzoBenjamin CoteGlen CowanKyle Stuart CranmerDavide CremoniniSabine Crepe-RenaudinFrancesco CrescioliMarkus CristinzianiMarco CristoforettiVincent Alexander CroftJacob Edwin CrosbyNanni CrosettiAna Rosario Cueto GomezTulay Cuhadar DonszelmannHan CuiZhaoyuan CuiLiam CunninghamFrancesco CurcioPatrick Karl CzodrowskiMarta CzuryloMario Jose SousaJoao Victor da Fonseca PintoCinzia da ViaWladyslaw DabrowskiTomas 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• Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont AstroParticule et Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers AstroParticule et Cosmologie Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie AstroParticule et Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : A search is reported for excited $\tau$-leptons and leptoquarks in events with two hadronically decaying $\tau$-leptons and two or more jets. The search uses proton-proton (pp) collision data at $\sqrt{s} = 13$ TeV recorded by the ATLAS experiment during the Run 2 of the Large Hadron Collider in 2015-2018. The total integrated luminosity is 139 fb$^{-1}$. The excited $\tau$-lepton is assumed to be produced and to decay via a four-fermion contact interaction into an ordinary $\tau$-lepton and a quark-antiquark pair. The leptoquarks are assumed to be produced in pairs via the strong interaction, and each leptoquark is assumed to couple to a charm or lighter quark and a $\tau$-lepton. No excess over the background prediction is observed. Excited $\tau$-leptons with masses below 2.8 TeV are excluded at 95% CL in scenarios with the contact interaction scale $\Lambda$ set to 10 TeV. At the extreme limit of model validity where $\Lambda$ is set equal to the excited $\tau$-lepton mass, excited $\tau$-leptons with masses below 4.6 TeV are excluded. Leptoquarks with masses below 1.3 TeV are excluded at 95% CL if their branching ratio to a charm quark and a $\tau$-lepton equals 1. The analysis does not exploit flavour-tagging in the signal region.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/03/2023
• Auteurs : Philippe CouvertPhilippe GiralPierre -Yves BoelleValérie CarreauSophie BéliardJean -Marc LacortePhilippe LesnikFrancois PaillardRené ValéroAnnelies RotthierEric BruckertAlain Carrié
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases

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• Type de publi. : Article dans une revue
• Date de publi. : 21/03/2023
• Auteurs : Antoine GavoilleFabien RollotRomain CaseyMarc DebouverieEmmanuelle Le PageJonathan CironJerome de SezeAurélie RuetElisabeth MaillartPierre LabaugeHelene ZephirCaroline PapeixGilles DeferChristine Lebrun-FrénayThibault MoreauDavid Axel LaplaudEric BergerBruno StankoffPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourrePhilippe CabreAbir WahabLaurent MagyJean-Philippe CamdessancheAude MauroussetSolène MoulinNasr Haifa BenDalia Dimitri BoulosKarolina HankiewiczJean-Philippe NeauCorinne PottierChantal NifleMuriel RabilloudFabien SubtilSandra Vukusic
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center CHU Pontchaillou [Rennes] Centre hospitalier universitaire de Poitiers Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Laboratoire d'Immunologie Service de Neurologie [CHU Pitié-Salpêtrière] Service de Neurologie [CHU Caen] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) CIC Plurithématique de Nantes Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Barcelona Supercomputing Center - Centro Nacional de Supercomputacion CHU Saint-Antoine [AP-HP] Centre de résonance magnétique biologique et médicale Hôpital Universitaire Carémeau [Nîmes] Institut de Génomique Fonctionnelle CHI Poissy-Saint-Germain Centre de résonance magnétique biologique et médicale Département biostatistiques et modélisation pour la santé et l'environnement [LBBE] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives: The question of the long-term safety of pregnancy is a major concern in multiple sclerosis (MS) patients, but its study is biased by reverse causation (women with higher disability are less likely to experience pregnancy). Using a causal inference approach, we aimed to estimate the unbiased long-term effects of pregnancy on disability and relapse risk in MS patients, and secondarily the short-term effects (during the per-partum and post-partum years) and delayed effects (occurring beyond one year after delivery). Methods: We conducted an observational cohort study with data from MS patients followed in the OFSEP registry between 1990 and 2020. We included MS female patients aged 18-45 years at MS onset, clinically followed-up for more than 2 years and with ≥3 Expanded Disease Status Scale (EDSS) measurements. Outcomes were the mean EDSS at the end of follow-up and the annual probability of relapse during follow-up. Counterfactual outcomes were predicted using the longitudinal targeted maximum likelihood estimator in the entire study population. The patients exposed to at least one pregnancy during their follow-up were compared with the counterfactual situation in which, contrary to what was observed, they would not have been exposed to any pregnancy. Short-term and delayed effects were analyzed from the first pregnancy of early-exposed patients (who experienced it during their first three years of follow-up). Results: We included 9,100 patients, with a median follow-up duration of 7.8 years, of whom 2,125 (23.4%) patients were exposed to at least one pregnancy. Pregnancy had no significant long-term causal effect on the mean EDSS at 9 years (causal mean difference [95% CI] = 0.00 [-0.16; 0.15]), nor on the annual probability of relapse (causal risk ratio [95% CI] = 0.95 [0.93; 1.38]). For the 1,253 early-exposed patients, pregnancy significantly decreased the probability of relapse during the per-partum year and significantly increased it during the post-partum year, but no significant delayed effect was found on EDSS and relapse rate. Discussion: Using a causal inference approach, we found no evidence of significantly deleterious or beneficial long-term effects of pregnancy on disability. The beneficial effects found in other studies were probably related to a reverse causation bias.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/03/2023
• Auteurs : Iannis DandourasMatt G G T TaylorJohan de KeyserYoshifumi FutaanaRuth A BamfordGraziella Branduardi-RaymontJean-Yves ChaufrayDragos ConstantinescuElisabetta de AngelisPierre DevotoJonathan EastwoodMarius EchimPhilippe GarnierBenjamin GrisonDavid HercikHelmut LammerAndré LaurensFrançois LeblancAnna MililloRumi NakamuraLubomír PřechElias RoussosŠtěpán ŠtverákJulien ForestArnaud TroucheSébastien L G HessJean-Charles Mateo- VélezJames CarpenterJosef Winter
• Organismes : Institut de recherche en astrophysique et planétologie
• Publié dans Frontiers in Astronomy and Space Sciences le 01/11/2020

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Résumé : The Lunar Orbital Platform-Gateway (LOP-Gateway, or simply Gateway) is a crewed platform that will be assembled and operated in the vicinity of the Moon by NASA and international partner organizations, including ESA, starting from the mid-2020s. It will offer new opportunities for fundamental and applied scientific research. The Moon is a unique location to study the deep space plasma environment. Moreover, the lunar surface and the surface-bounded exosphere are interacting with this environment, constituting a complex multi-scale interacting system. This paper examines the opportunities provided by externally mounted payloads on the Gateway in the field of space plasma physics, heliophysics and space weather, but also examines the impact of the space environment on an inhabited platform in the vicinity of the Moon. It then presents the conceptual design of a model payload, required to perform these space plasma measurements and observations. It results that the Gateway is very well-suited for space plasma physics research. It allows a series of scientific objectives with a multidisciplinary dimension to be addressed.

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Fichiers liés : Dandouras et al_Gateway Space Plasma Physics _FrontiersAstronomySpaceSci_2023.pdf

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