Philippe Jean-Pierre

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/1991
• Auteurs : Philippe DemuyterDominique SchneiderPierre LeblondJean-Marc SimonetBernard Decaris
• Organismes : Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie
• Publié dans Journal of general microbiology le 26/10/2020

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Résumé : Genetic instability in Strepfomyces ambofaciens DSM 40697 involves genomic rearrangements such as amplifications and deletions of particular DNA sequences. Most amplifications were located in two amplifiable regions, one of which, called AUD6 (amplifiable unit of DNA no. 6) was revealed to be a rearrangement hotspot. Indeed, 30% of the mutant strains studied had amplifications, deletions or both at the AUD6 locus. This locus contains several reiterations which are specific to this AUD. Moreover, one of the endpoints of the AUD6 shows homology with an internal sequence. Deletions occurred exclusively at one side of the amplified DNA sequence (ADS) and removed part of the proximal copy of this ADS, leading to the conclusion that multiple rearrangements can occur at this AUD locus.

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Fichiers liés : mic-137-3-491.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/1991
• Auteurs : Jocelyne CabochePhilippe VernierJean-François JulienMonique RogardJacques MalletMarie-Jo Besson
• Organismes : Laboratoire de Neurochimie Anatomie Laboratoire de neurobiologie cellulaire et moléculaire Laboratoire de neurobiologie cellulaire et moléculaire Laboratoire de Neurochimie Anatomie Laboratoire de neurobiologie cellulaire et moléculaire Laboratoire de Neurochimie Anatomie
• Publié dans Journal of Neurochemistry le 25/10/2020

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Résumé : The levels of mRNA encoding glutamic acid decarboxylase (GAD) and preproenkephalin (PPE) were measured by Northern blot analysis, in the dorsal and the ventral part of the striatum, following long-term treatments with drugs acting selectively on D1 or D2 dopaminergic receptors. Chronic injection of the selective D1 antagonist SCH 23390 elicited a significant decrease in level of both GAD and PPE mRNA (-30%) in the dorsal striatum, whereas no significant change was observed in the ventral striatum. Chronic administration of both SCH 23390 and RU 24926, a D2 agonist, decreased the GAD and PPE mRNA levels in the dorsal (-38 and -57%, respectively) as well as in the ventral (-70 and -60%, respectively) striatum. In the ventral striatum the marked reduction of GAD mRNA levels was paralleled by a significant decrease of Vmax values of GAD enzymatic activity (-41%). These results suggest that the decrease in content of both GAD and PPE mRNA, promoted by the chronic blockade of D1 receptors, is mainly due to the action of dopamine acting on unaffected D2 receptors. Indeed, this decrease is further amplified when the D2 agonist and the D1 antagonist are administered together. Our results substantiate further the molecular mechanisms by which dopamine acts on different populations of GABAergic and enkephalinergic neurons in the two striatal regions examined.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Michel CallonJean-Pierre CourtialPhilippe CrancePhilippe LarédoPhilippe MauguinVololona RabeharisoaYves-André RocherDominique Vinck
• Organismes : Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3 Centre de Sociologie de l'Innovation i3
• Publié dans Technology Analysis & Strategic Management le 09/04/2008

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• Type de publi. :
• Date de publi. : 01/01/1991
• Auteurs : Mohamed HimdiJean Pierre DanielPhilippe Dupuis
• Organismes : Institut d'Électronique et des Technologies du numéRique Institut d'Électronique et des Technologies du numéRique CRITT Ct Reg Innovat Transfert Tech

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/1991
• Auteurs : Pierre BoherPhilippe HoudyLouis HennetZhigang LiAbhijit ModakDavid SmithM. IdirT. MorenoRobert BarchewitzMikhael KuehnePeter MuellerJean-Pierre Delaboudiniere
• Organismes : Laboratoire d'électronique de Philips Laboratoire d'électronique de Philips Laboratoire d'électronique de Philips Arizona State University [Tempe] Arizona State University [Tempe] Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Laboratoire de Chimie Physique - Matière et Rayonnement Institut d'astrophysique spatiale

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Jean-Philippe MazzucotelliC Klein-SoyerAlain BeretzC BrissonGisele Haan-ArchipoffJean-Pierre Cazenave
• Organismes : Nanomédecine Régénérative Université Louis Pasteur - Strasbourg I Institut de Biologie Moléculaire des Plantes Laboratoire d'Analyses de Biologie Médicale
• Publié dans The International Journal of Artificial Organs le 28/10/2020

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Résumé : The establishment of an endothelial lining on vascular grafts to obtain a highly thromboresistant surface in a clinical situation requires optimization of cell collection, quality, adhesion and growth. We have studied the conditions for collection, seeding and growth of human saphenous vein endothelial cells (HSVEC), on Dacron or Gore-Tex expanded polytetrafluoroethylene (PTFE) vascular grafts. Carefully handled veins, as opposed to veins obtained using the usual procedures for coronary bypass graft preparation, yielded a higher rate of successful culture (94% vs 43%) and reached confluence in primary culture sooner (9.4 +/- 3 days vs 13.4 +/- 4.5 days). HSVEC were seeded at a density of 6 x 10(3) cells/cm2 on graft fragments coated with fibronectin (FN) or Transglutine (TGL), a biological glue. There was no HSVEC adhesion on Dacron or PTFE without protein pretreatment of the artificial surface. FN improved HSVEC adhesion but there was no cell growth. Adhesion, doubling time and cell density at confluence on PTFE pretreated with TGL were similar to those on conventional tissue culture polystyrene (TCP) pretreated with TGL or FN. HSVEC adhesion on Dacron pretreated with TGL was lower than on TCP pretreated with TGL; the doubling time was similar but the density at confluence was 40% lower. We conclude that pretreatment of vascular grafts with TGL, besides being an alternative to preclotting of the Dacron graft, allows adhesion and growth to confluence of HSVEC on these surfaces.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Ginette SaraccoJean-Pierre SessaregoJean SageloliPhilippe GuillemainRichard Kronland-Martinet
• Organismes : Laboratoire de Mécanique et d'Acoustique [Marseille] Centre européen de recherche et d'enseignement des géosciences de l'environnement Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille]
• Publié dans Research Notes in Applied Mathematics, Masson-Springer le 27/06/2007

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Résumé : This paper isconcerned with the characterization of elastic targets immersed in a fluid and submitted to an acoustic impulse. Time-frequency methods have already been used in the case of scatterers of simple geometric shape. We have chosen the wavelet transform for its particular properties, such as linearity and local analysis at Df/f=Cst. We have developped an algorithm based on the behavior of the phase of the transform, which enables us to extract modulation laws (related to the dispersion law of the phase velocity), even for close echoes. In the case of spherical elastic shells,we have applied this method to both experimental and simulated signals. We point out the good agreement between theoretical ans experimental results.

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Fichiers liés : SpringMas91SSSGKM.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Pierre LeblondPhilippe DemuyterJean-Marc SimonetBernard Decaris
• Organismes : Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie Laboratoire de génétique et microbiologie
• Publié dans Journal of Bacteriology le 02/11/2020

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Résumé : Using pulsed-field gel electrophoresis (PFGE) analysis, the amplifiable units of DNA (AUD) loci AUD6 and AUD90 of Streptomyces ambofaciens DSM40697 could be mapped in the wild-type genome within two adjacent AseI restriction fragments estimated to be about 75 and 850 kb. In addition, the genetic instability and formation of very large deletions were strictly correlated. Their sizes were estimated to range from 250 to more than 2,000 kb. These deletions affected the DNA region overlapping both amplifiable loci. PFGE also allowed us to localize the amplified DNA sequences and to establish their structure: amplification takes place at the AUD locus as a tandem array of the wild-type AUD sequence.

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Fichiers liés : J. Bacteriol.-1991-Leblond-4229-33.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Jean-Michel CourtyPhilippe GrangierLaurent HilicoSerge Reynaud
• Organismes : Université Pierre et Marie Curie - Paris 6 Laboratoire Charles Fabry de l'Institut d'Optique / Optique quantique Université Pierre et Marie Curie - Paris 6 Université Pierre et Marie Curie - Paris 6
• Publié dans Optics Communications le 02/11/2020

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Résumé : We present a new method for computing quantum fluctuations of fields emitted by optical cavities containing atoms. The noise generation by atoms is described by atomic correlation functions. The parametric transformation of the fields by the atomic medium is described by susceptibility functions, as in linear response theory. The susceptibility functions and the correlation functions can be calculated as in the resonance fluorescence theory. The compatibility between dissipation and added fluctuations is ensured by general relations existing between these atomic functions.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1991
• Auteurs : Laurent JolivetPhilippe HuchonXavier Le PichonNicolas Chamot-RookeJean-Charles ThomasJean-Pierre Brun
• Organismes : Département de Géologie Institut des Sciences de la Terre d'Orléans Département de Géologie Institut des Sciences de la Terre de Paris Département de Géologie Collège de France - Chaire Géodynamique Département de Géologie Laboratoire de géologie de l'ENS Département de Géologie Centre National de la Recherche Scientifique
• Publié dans Journal of Geophysical Research : Solid Earth le 27/10/2020

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Résumé : We discuss the opening mechanism of the Japan Sea in Miocene time using (1) tectonic and published paleomagnetic data along the eastern margin from the north of Hokkaido Island to Sado Island, (2) a mechanical model which is tested by small-scale physical modeling, and (3) crustal structure and bathymetric features in the Japan Sea which constrain our kinematic model and preopening reconstructions. Our main conclusions are the following. The eastern margin of the Japan Sea was, as a whole, a dextral shear zone about 100 km wide. This conclusion is supported by the existence of a ductile dextral shear zone in Central Hokkaido (Hidaka Mountains) and associated brittle deformation in western Hokkaido and northeastern Honshu. The stress field during the opening (which ended about 12 Ma ago at the end of the middle Miocene) changes from right-lateral transpression in the north to right-lateral transtension in the south. The western margin, along the Korean peninsula, during the same period, also was an active dextral shear zone. Paleomagnetic results indicate that clockwise rotations occurred in the south during the opening and counterclockwise rotations in the north. We propose a model of right-lateral pull-apart deformation with clockwise rotations of rigid blocks in the southern transtensional domain and counterclockwise rotations in the transpressional one. Small-scale physical models show that the clockwise rotation in transtension is possible provided that the eastern boundary (Pacific side) is free of stress. The opening stopped and compression subsequently began about 12 Ma ago. Finally, we show that the dextral shear, which is distributed over the whole Japan Sea area, is accommodated by N-S trending right-lateral faults and rotation of blocks located between these right-lateral faults.

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Fichiers liés : 90JB02455.pdf

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