Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Charlotte Bert-MarcazÉtienne FortanierAntoine BriantaisBenoît FaucherRim BourguibaLaure SwiaderNicolas SchleinitzGiovanni CorazzaRodolphe JeanAdrien BigotPaola Marianetti-GuingelMarie KostineRoderau OuthYannick DieudonnéEstibaliz LazaroGuillaume VialSylvain PalatSimon FrachetSébastien de Almeida ChavesStéphane VinzioKarim SacréMarie RobertThilbault ComontJérémie DionPierre GirardieValentin LacombeVincent LangloisVincent JachietPaul DeckerThomas MoulinetSylvie GrosleronJonathan BronerPhilippe GuilpainMaxime SamsonBenjamin TerrierSophie Georgin-LavialleSharham AttarianArsène MekinianEmilien DelmontMikael EbboIsabelle MelkiLionel AdesLin Pierre ZhaoAlexandra AudemardOdile Beyne RauzyAlexandre BelotRaphaël BorieYgal BenhamouGaetan SauvetreKhalil El-KarouiFrançois RodriguesLouis TerriouJérome HadjadjYann NguyenDalila MouloudjMaël HeibligHassina AlouiChloe McavoySamuel ArdoisCorrado CampochiaroAlexandre MariaCyrille CoustalThibault ComontFrancois LifermannGuillaume Le GuennoHervé LobbesTomas UrbinaVincent GrobostJulien CampagneAnais Dor-EtienneAlice GarnierYvan JamillouxAntoine DossierSylvain AudiaBarbara NicolasAlexis MathianBaptiste de MalepradeBenjamin de Sainte-MarieJean-David BouazizCyril DumainCarole AntoineBenjamin CarpentierBrice CastelCeline Lartigau-RoussinÉtienne CrickxGeoffroy VolleDamien FayardAnael DumontAlexandre NguyenAchille AoubaJean-Philippe MartellosioMatthieu LevavasseurSebastien PuigrenierPascale AntoineJean-Thomas GiraudOlivier HermineCarole LacoutNihal MartisJean-Denis KaramFrancois ChassetLaurent ArnaudAntoine NéelLamia BoukirPaola MarianettiChristophe DelignyThibaud ChazalPascal Woaye-HuneMurielle Roux-SauvatAurore MeyerPierre SujobertPierre HirschNoemie AbisrorPierre FenauxOlivier KosmiderVincent JachietOlivier Fain
• Organismes : Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Centre Hospitalier Universitaire Mongi Slim [La Marsa] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital de la Conception [CHU - APHM] Centre Hospitalier Régional Universitaire de Tours Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Saint Jean de Perpignan Nouvel Hôpital Civil de Strasbourg Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux CHU Limoges CHU Limoges Centre Hospitalier Universitaire de Toulouse Groupe Hospitalier Mutualiste de Grenoble [France] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier du Haut Anjou [Château-Gontier, France] Groupe Hospitalier du Havre AP-HP - Hôpital Saint-Antoine Centre Hospitalier Régional Universitaire de Nancy Ingénierie Moléculaire, Cellulaire et Physiopathologie Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Agen-Nérac Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand AP-HP - Hôpital Cochin AP-HP - Hôpital Tenon Hôpital de la Timone [CHU - APHM] AP-HP - Hôpital Saint-Antoine Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM]
• Publié dans Journal of Neurology le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Pietro AddeoMilena MuzzoliniChristophe LaurentBruno HeydAlain SauvanetJonathan GarnierMarie Sophie AlfanoSébastien GaujouxCharles de PonthaudUgo MarcheseDoris da SilvaEmmanuel BucRegis SoucheJean Michel FabrePierre-Emanuel ColomboLorenzo FerreMaxime FoguenneCatherine HubertMehdi El AmraniStephanie TruantLilian SchwartzNicolas RegenetAurelien DupreRaffaele BrustiaRim CherifJulie NavezBenjamin DarnisOlivier FacyRobin GrelletGuillaume PiessenJulie VeziantRami RhaiemReza KianmaneshElena Fernandez-De-SevillaMaximiliano GelliAbdelkader TaibiPauline GeorgesJean Yves MabrutMickael LesurtelAlexandre DoussotPhilippe Bachellier
• Organismes : Hôpital de Hautepierre [Strasbourg] AP-HP - Hôpital Beaujon Hôpital Haut-Lévêque [CHU Bordeaux] Centre Hospitalier Régional Universitaire de Besançon AP-HP - Hôpital Beaujon Institut Paoli-Calmettes Institut Paoli-Calmettes AP-HP - Hôpital de la Pitié Salpêtrière AP-HP - Hôpital de la Pitié Salpêtrière Health data-and model-driven approaches for Knowledge Acquisition AP-HP - Hôpital Cochin AP-HP - Hôpital Cochin CHU Clermont-Ferrand Hôpital Saint Eloi [CHU Montpellier] Hôpital Saint Eloi [CHU Montpellier] UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle Cliniques Universitaires Saint-Luc [Bruxelles] Cliniques Universitaires Saint-Luc [Bruxelles] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Rouen Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Léon Bérard [Lyon] AP-HP - Hôpital Henri-Mondor AP-HP - Hôpital Henri-Mondor Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis Clinique de la Sauvegarde [Lyon] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital Claude Huriez [Lille] Hôpital Claude Huriez [Lille] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Institut Gustave Roussy Département d'anesthésie [Gustave Roussy] Institut Gustave Roussy Département d'anesthésie [Gustave Roussy] Dynamique des cellules tumorales Centre Hospitalier Universitaire Dupuytren 1 et 2 Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] AP-HP - Hôpital Beaujon Centre Hospitalier Régional Universitaire de Besançon Hôpital de Hautepierre [Strasbourg]
• Publié dans Annals of Surgical Oncology le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Kim GénuitePierre VoinchetCarole NehmeDominique TodiscoJean-Jacques BahainDaniel BallesterosAndrew FarrantIgor GiraultJ. Michael GrapponeAnne PhilippeWilliam RapucDamase Mouralis
• Organismes : Environnements, Dynamiques et Territoires de Montagne De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Histoire naturelle de l'Homme préhistorique Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés Université de Rouen Normandie Histoire naturelle de l'Homme préhistorique Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés British Geological Survey Histoire naturelle de l'Homme préhistorique University of Liverpool Laboratoire de Mathématiques Jean Leray Environnements, Dynamiques et Territoires de Montagne Durham University Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés
• Publié dans Quaternary Science Reviews le 27/10/2020

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Résumé : In this paper we present a detailed Quaternary evolution model of the Seine valley (France). The lower Seine valley contains very specific preserved morphological features (semi-entrenched meander cut-offs) and develops in a karstified chalky plateau (Normandy Chalk). Regional geomorphological features make it possible to combine geomorphological observations, petrological investigations as well as cross-dating analysis of fluvial sediments and karstic archives. We have reviewed former chronological data through a combination of different dating methods including ESR, U-series as well as palaeomagnetism. We also present here new dating results from both cave deposits and fluvial terrace sediments through the combined use of quartz ESR dating method and palaeomagnetism. The obtained results show river evolution extending over the entire Quaternary period. The gentle incision rate and its variations highlight the influence of climate and eustatic processes, hence a partially climate-induced uplift. Results also provide new chronological markers on the fluvial deposits for future archaeological research.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Jean-Charles NaultMarouane BoubayaMyriam WartskiAnthony DohanStanislas PolGabriel PopMichael SoussanOlivier SutterCharlotte CostentinJulie RouxChristian SengelMarie LequoyFrançoise MontraversYves MenuGeorges-Philippe PageauxDenis Mariano-GoulartBoris GuiuAlain LucianiPierre NahonMarco Dioguardi BurgioMathilde WagnerPhilippe MaksudSebastien MuléManon AllaireSabrina SidaliAudrey CoillyFlorent BessonMaïté LewinHélène RegnaultClémence HollandeGiuliana AmaddeoMaxime RonotNathalie Ganne-CarriéEmmanuel IttiCoralie Bloch-QueyratVincent LevyRachida LebtahiJulia ChalayeMohamed Bouattour
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiopathogénèse et Traitement des Maladies du Foie
• Publié dans The Lancet Gastroenterology & Hepatology le 22/10/2020

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Fichiers liés : 2025 Nault et al., 18F.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Pierre SenersJean-Claude BaronAnke WoutersJean‐philippe DesillesFernando PicoRichard MacrezJean Marc OlivotRobin LemmensGregory W AlbersMaarten Lansberg
• Organismes : Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Institut de psychiatrie et neurosciences de Paris French-Clinical Research Infrastructure Network - F-CRIN [Paris] Institut de psychiatrie et neurosciences de Paris Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Catholic University of Leuven = Katholieke Universiteit Leuven Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain French-Clinical Research Infrastructure Network - F-CRIN [Paris] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Optimisation thérapeutique en Neuropsychopharmacologie French-Clinical Research Infrastructure Network - F-CRIN [Paris] Centre Hospitalier de Versailles André Mignot Université Paris-Saclay French-Clinical Research Infrastructure Network - F-CRIN [Paris] Physiopathologie et imagerie des troubles neurologiques French-Clinical Research Infrastructure Network - F-CRIN [Paris] Centre d'investigation clinique de Toulouse Catholic University of Leuven = Katholieke Universiteit Leuven Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Stanford University Stanford University
• Publié dans Stroke le 31/10/2020

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Résumé : Currently, most acute ischemic stroke patients presenting with a large vessel occlusion are first evaluated at a nonthrombectomy-capable center before transfer to a comprehensive stroke center that performs thrombectomy. Interfacility transfer is a complex process that requires extensive coordination between the referring, transporting, and receiving facilities. As a result, long delays are common, contributing to poor clinical outcomes. In this review, we summarize the accumulating literature about the clinical as well as radiological-infarct growth, collateral change, arterial recanalization, and hemorrhagic transformation-changes during interfacility transfer for thrombectomy. Recent evidence shows that clinical/radiological changes during transfer are heterogeneous across patients and impact long-term functional outcomes, highlighting the urgent need to optimize care during this time window. We review some of the most promising therapeutic strategies-for example, penumbral protection to reduce infarct growth-that may improve clinical outcome in patients being transferred to thrombectomy-capable centers. Finally, we discuss key methodological considerations for designing clinical trials aimed at reducing infarct growth during transfer.

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Fichiers liés : Seners et al Stroke 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Carlo FischerTongai Gibson MapongaAnges YadouletonNuro AbílioEmmanuel AbocePraise AdewumiPedro AfonsoJewelna AkorliSoa Fy AndriamandimbyLatifa AngaYvonne AshongMohamed Amine BeloufaAicha BensalemRichard BirtlesAnicet Luc Magloire BoumbaFreddie BwangaMike ChapondaParadzai ChibukiraR Matthew ChicoJustin ChilesheWonderful ChogaGershom ChongweAssana CisséFatoumata CisséUmberto D’alessandroXavier de LamballerieJoana de MoraisFawzi DerrarNdongo DiaYoussouf DiarraLassina DoumbiaChristian DrostenPhilippe DussartRichard EchoduAbdelmajid EloualidOusmane FayeTorsten FeldtAnna FrühaufSimani GaseitsiweAfiwa HalatokoEtuhole IipumbuPauliana-Vanessa IlougaNalia IsmaelRonan JambouSheikh JarjuAntje KampradBen KatowaJohn KayiwaLeonard King’waraOusmane KoitaVincent LacosteAdamou LagareOlfert LandtSonia Etenna Lekana-DoukiJean-Bernard Lekana-DoukiHugues LoembaTom LueddeJulius LutwamaSantou MamadouIssaka MamanBrendon ManyisaPedro MartinezJaphet MatobaLusia MhuuluAndrés Moreira-SotoSikhulile MoyoJudy MwangiNadine N’dilimabakaCharity Angella NassunaMamadou Ousmane NdiathEmmanuel NepoloRichard NjouomJalal NourlilSteven Ger NyanjomEddy Okoth OdariAlfred OkengJean Bienvenue OuobaMichael OwusuIrene Owusu DonkorKarabo Kristen PhaduRichard Odame PhillipsWolfgang PreiserPierre RoquesVurayai RuhanyaFortune SalahSourakatou SalifouAmadou Alpha SallAugustina Angelina SylverkenPaul Alain Tagnouokam-NgoupoZekiba TarnagdaFrancis Olivier TchikayaNoël TordoTafese Beyene TufaJan Felix Drexler
• Organismes : Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Stellenbosch University - Universiteit Stellenbosch [South Africa] National Health Laboratory Service [Johannesburg, South Africa] Laboratoire des Fièvres hémorragiques virales [Cotonou, Bénin] Instituto Nacional de Saude [Maputo, Mozambique] MBN Clinical Laboratories [Kampala, Uganda] Laboratoire des Fièvres hémorragiques virales [Cotonou, Bénin] Instituto Nacional de Investigação em Saúde - National Institute for Health [Luanda, Angola] Université du Ghana = University of Ghana Institut Pasteur de Madagascar Institut Pasteur du Maroc Université du Ghana = University of Ghana Institut Pasteur d'Algérie Institut Pasteur d'Algérie Gulu University University of Salford Université Marien-Ngouabi [Université de Brazzaville] = Marien Ngouabi University [University of Brazzaville] Molecular Diagnostic Laboratory HDL [Pointe Noire, République Démocratique du Congo] MBN Clinical Laboratories [Kampala, Uganda] Makerere University [Kampala, Ouganda] Tropical Diseases Research Centre [Zambia] University of Zimbabwe London School of Hygiene & Tropical Medicine [Fajara, The Gambia] Tropical Diseases Research Centre [Zambia] Botswana Harvard AIDS Institute Partnership University of Botswana Tropical Diseases Research Centre [Zambia] Laboratoire National de Référence-Grippes [Ouagadougou, Burkina Faso] Institut Pasteur de Guinée London School of Hygiene & Tropical Medicine [Fajara, The Gambia] Unité des Virus Emergents Instituto Nacional de Investigação em Saúde - National Institute for Health [Luanda, Angola] Institut Pasteur d'Algérie Institut Pasteur de Dakar Université des Sciences, des Techniques et des Technologies de Bamako Université des Sciences, des Techniques et des Technologies de Bamako Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin German Centre for Infection Research Institut Pasteur de Madagascar Gulu University Institut Pasteur du Maroc Institut Pasteur de Dakar University Hospital Düsseldorf Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Botswana Harvard AIDS Institute Partnership Harvard T.H. Chan School of Public Health Institut National D'Hygiène [Lomé, Togo] University of Namibia Centre Pasteur du Cameroun Instituto Nacional de Saude [Maputo, Mozambique] Centre de Recherche Médicale et Sanitaire [Niamey, Niger] London School of Hygiene & Tropical Medicine [Fajara, The Gambia] Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Macha Research Trust [Macha, Zambia] Uganda Virus Research Institute Ministry of Health [Kenya] Université des Sciences, des Techniques et des Technologies de Bamako Institut Pasteur de Madagascar Centre de Recherche Médicale et Sanitaire [Niamey, Niger] TIB MOLBIOL GmbH [Berlin] Centre Interdisciplinaire de Recherches Médicales de Franceville Centre Interdisciplinaire de Recherches Médicales de Franceville Molecular Diagnostic Laboratory HDL [Pointe Noire, République Démocratique du Congo] Université d'Ottawa = University of Ottawa [Ontario] University Hospital Düsseldorf Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Uganda Virus Research Institute Centre de Recherche Médicale et Sanitaire [Niamey, Niger] Institut National D'Hygiène [Lomé, Togo] University of Zimbabwe Instituto Nacional de Investigação em Saúde - National Institute for Health [Luanda, Angola] Macha Research Trust [Macha, Zambia] University of Zambia [Lusaka] University of Namibia Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin Botswana Harvard AIDS Institute Partnership University of Botswana Harvard T.H. Chan School of Public Health University of Pretoria [South Africa] Stellenbosch University - Universiteit Stellenbosch [South Africa] Gulu University University of Salford Centre Interdisciplinaire de Recherches Médicales de Franceville Uganda Virus Research Institute London School of Hygiene & Tropical Medicine [Fajara, The Gambia] University of Namibia Centre Pasteur du Cameroun Institut Pasteur du Maroc Jomo Kenyatta University of Agriculture and Technology Jomo Kenyatta University of Agriculture and Technology MBN Clinical Laboratories [Kampala, Uganda] Laboratoire National de Référence-Grippes [Ouagadougou, Burkina Faso] Kumasi Centre for Collaborative Research in Tropical Medicine Université du Ghana = University of Ghana Stellenbosch University - Universiteit Stellenbosch [South Africa] Kumasi Centre for Collaborative Research in Tropical Medicine Stellenbosch University - Universiteit Stellenbosch [South Africa] National Health Laboratory Service [Johannesburg, South Africa] Institut Pasteur de Guinée Institut de Biologie François JACOB University of Zimbabwe Institut National D'Hygiène [Lomé, Togo] Ministère de la Santé - Ministry of Health [Cotonou, Bénin] Institut Pasteur de Dakar Kumasi Centre for Collaborative Research in Tropical Medicine Kwame Nkrumah University of Science and Technology Centre Pasteur du Cameroun Laboratoire National de Référence-Grippes [Ouagadougou, Burkina Faso] Molecular Diagnostic Laboratory HDL [Pointe Noire, République Démocratique du Congo] Institut Pasteur de Guinée University Hospital Düsseldorf Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Freie Universität Berlin = Free University of Berlin Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin German Centre for Infection Research
• Publié dans The Lancet global health le 26/10/2020

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Résumé : Background: In mid-November, 2021, the SARS-CoV-2 omicron variant (B.1.1.529; BA.1 sublineage) was detected in southern Africa, prompting international travel restrictions. We aimed to investigate the spread of omicron BA.1 in Africa. Methods: In this observational study, samples from patients infected with SARS-CoV-2 from 27 laboratories in 24 African countries, collected between June 1, 2021 and April 14, 2022, were tested for omicron BA.1 and delta (B.1.617.2) variants using real-time RT-PCR. Samples that tested positive for BA.1 by RT-PCR and were collected before estimated BA.1 emergence according to epidemiological properties were excluded from downstream analyses. The diagnostic precision of the assays was evaluated by high-throughput sequencing of samples from four countries. The observed spread of BA.1 was compared with mobility-based mathematical simulations and entries for SARS-CoV-2 in the Global Initiative on Sharing All Influenza Data (GISAID) genomic database. We estimated the effective reproduction number (Rt) at the country level considering the BA.1 fraction and the reported numbers of infections. Phylogeographical analyses were done in a Bayesian framework. Findings: Through testing of 13 294 samples from patients infected with SARS-CoV-2, we established that, by November-December, 2021, omicron BA.1 had replaced the delta variant of SARS-CoV-2 in all African subregions, following a south-north gradient, with a median Rt of 2·60 (95% CI 2·46-2·71). This south-north spread, established on the basis of PCR data, was substantiated by phylogeographical reconstructions, ancestral state reconstructions, and GISAID data. PCR-based reconstructions of country-level BA.1 predominance and the availability of BA.1 genomic sequences in GISAID correlated significantly in time (p=0·0002, r=0·78). The first detections of BA.1 in high-income settings beyond Africa were predicted accurately in time by mobility-based mathematical simulations (p<0·0001). Comparing PCR-based reconstructions with mobility-based mathematical simulations suggested that SARS-CoV-2 infections in Africa were under-reported by approximately ten times. Inbound travellers infected with BA.1, departing from five continents, were identified in six African countries by early December, 2021. Interpretation: Omicron BA.1 was widespread in Africa when travel bans were implemented, limiting their effectiveness. Combined with genomic surveillance and mobility-based mathematical modelling, PCR-based strategies can inform Rt and the geographical spread of emerging pathogens in a cost-effective and timely manner, and can guide evidence-based, non-pharmaceutical interventions such as travel restrictions or physical distancing.

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Fichiers liés : PIIS2214109X24004194.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Aurélien DinhFrançois BarbierJean-Pierre BedosMathieu BlotVincent CattoirYann-Eric ClaessensXavier DuvalPierre FillâtreMaxime GautierYann GueganSophie JarraudAlban Le MonnierDavid LebeauxPaul LoubetConstance De MargeriePhilippe SerayetYacine Tandjaoui-LambotteEmmanuelle VaronYves WelkerDamien Basille
• Organismes : AP-HP - Hôpital Raymond Poincaré Université Paris-Saclay Assistance publique - Hôpitaux de Paris Centre Hospitalier Universitaire d'Orléans Service de réanimation [CH Versailles] Département d'infectiologie (CHU de Dijon) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Emergency department, Hospital Princesse Grace Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] ESCMID [Basel] Pathogenèse des légionelles- Legionella pathogenesis [CIRI] MICrobiologie de l'ALImentation au Service de la Santé Groupe Hospitalier Paris Saint-Joseph Service de Microbiologie [CHU GeorgesPompidou] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Intercommunal de Créteil Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Pneumologie [CHU Amiens]
• Publié dans Respiratory Medicine and Research le 28/10/2020

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Résumé : Community-Acquired Pneumonia (CAP) of Presumed Bacterial Origin: Updated Management Guidelines Community-acquired pneumonia (CAP) of presumed bacterial origin is a common condition with varying severity, requiring either outpatient, hospital, or even critical care management. The French Infectious Diseases Society (SPILF) and the French Language Pulmonology Society (SPLF), in collaboration with the French Societies of Microbiology (SFM), Emergency Medicine (SFMU), Radiology (SFR), and Intensive Care Medicine (SRLF), along with representatives of general practice, have coordinated an update of the previous management guidelines, which dated back to 2010. From a therapeutic perspective, the updated recommendations define the choice of initial empiric antibiotic therapy, indications for combination therapy, the use of anti-Pseudomonas beta-lactams, antibiotic treatment duration, and the indications and modalities for prescribing systemic corticosteroids. On a biological level, indications for biomarkers and microbiological investigations have been refined. Regarding imaging, the role of different modalities in the diagnosis and follow-up of CAP has been reassessed, including chest X-ray, pleuropulmonary ultrasound, and thoracic CT scan.

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Fichiers liés : 1-s2.0-S259004122500008X-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Patrick GérardinRaïssa Medina SantosSigrid Le ClercLéa BruneauAdrien MaillotTaoufik LabibMyriam RahmouniJean-Louis SpadoniJean-Philippe MeynielClémence CornetCécile LefebvreNora El JahraniJakub SavaraMano Joseph MathewChristine FontaineChristine PayetNathalie Ah-YouCécile ChabertCorinne MussardSylvaine PorcheratSamir MedjaneJosselin NoirelCatherine MarimoutouHakim HociniJean-François Zagury
• Organismes : Centre d'Investigation Clinique de La Réunion - INSERM Laboratoire Génomique, bioinformatique et chimie moléculaire Laboratoire Génomique, bioinformatique et chimie moléculaire Centre Hospitalier Universitaire de La Réunion Centre Hospitalier Universitaire de La Réunion Laboratoire Génomique, bioinformatique et chimie moléculaire Laboratoire Génomique, bioinformatique et chimie moléculaire Laboratoire Génomique, bioinformatique et chimie moléculaire ISoft [Saint-Aubin] Aix-Marseille Université - École de maïeutique Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Institut Mondor de Recherche Biomédicale Vaccine Research Institute [Créteil, France] Efrei Research Lab Department of Computer Science [Ostrava] Univerzita Palackého [Olomouci] Efrei Research Lab Efrei (Villejuif / Bordeaux) Laboratoire Génomique, bioinformatique et chimie moléculaire CHU Sud Saint Pierre [Ile de la Réunion] CHU Sud Saint Pierre [Ile de la Réunion] Centre Hospitalier Universitaire de La Réunion CHU Sud Saint Pierre [Ile de la Réunion] Centre d'Investigation Clinique de La Réunion - INSERM Centre Hospitalier Universitaire de La Réunion Centre d'Investigation Clinique de La Réunion - INSERM Centre Hospitalier Universitaire de La Réunion CHU Sud Saint Pierre [Ile de la Réunion] Laboratoire Génomique, bioinformatique et chimie moléculaire Centre d'Investigation Clinique de La Réunion - INSERM CHU Sud Saint Pierre [Ile de la Réunion] Vaccine Research Institute [Créteil, France] Laboratoire Génomique, bioinformatique et chimie moléculaire
• Publié dans Travel Medicine and Infectious Disease le 25/10/2020

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Résumé : In 2005-2006, a chikungunya epidemic of unprecedented magnitude hit Reunion Island, which raised a public health concern through the substantial proportions of long-lasting manifestations. To understand the pathophysiology underlying chronic chikungunya (CC), we designed the CHIKGene cohort study and collected blood samples from 133 subjects diagnosed with CC and from 86 control individuals that had recovered within 3 months, 12-to-15 years after exposure.We conducted bulk RNAseq analysis on peripheral blood mononuclear cells to find differentially expressed genes (DEGs), gene set enrichment analysis (GSEA) and gene ontologies to uncover top-level enriched terms associated with DEGs, and weighted gene correlation network analysis (WGCNA) to elucidate underlying cellular processes.Among 1549 DEGs, gene expression analysis identified 10 top genes including NR4A2 and TRIM58 (upregulated in CC), IGHG3 and IGHV3-49 (downregulated in CC) linked to immune regulation, OSBP2 (upregulated in CC) and SEMA6B (downregulated in CC) linked to neuronal homeostasis and axon guidance, respectively. GSEA and WGCNA unveiled cellular processes such as "Metabolism of RNA" and "Cell Cycle”.This study uncovers a shift in gene expression of CC subjects. IGHG3 and IGHV3-49 gene shut-offs spotlight the importance of neutralizing antibodies against chikungunya virus in the progression to chronic disease. Human diseases associations highlight connections to rheumatoid arthritis, nervous and cardiac systems. GSEA and WGCNA bounce the hypotheses of a persistent viral reservoir or an increased susceptibility to RNA viral pathogens with new onset infections. Together, our findings might offer potential targets for therapeutic options aimed at alleviating chronic chikungunya.

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Fichiers liés : 1-s2.0-S1477893925000316-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Goran Stanajic-PetrovicMathilde KeckPeggy BarbeApolline UrmanEvelyne CorreiaPierre IsnardJean-Paul DuongKhawla ChmeisSékou Siramakan DiarraStefano PaleaFrederic TheodoroAnvi-Laëtitia NguyenFlorence CastelliAlain PruvostWenchao ZhaoChristiane MendreBernard MouillacFrank BienaiméPhilippe RobinPascal KesslerCatherine Llorens-CortesDenis ServentHervé NozachBernard MaillèreDong GuoCharles TruilletNicolas Gilles
• Organismes : Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) AP-HP - Hôpital Necker - Enfants Malades AP-HP - Hôpital Necker - Enfants Malades LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay Humana Biosciences, Prologue Biotech, 516 Rue Pierre et Marie Curie, 31670, Labège, France. Humana Biosciences, Prologue Biotech, 516 Rue Pierre et Marie Curie, 31670, Labège, France. Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Xuzhou Medical University Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut Necker Enfants-Malades AP-HP - Hôpital Necker - Enfants Malades Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO) Xuzhou Medical University LaBoratoire d'Imagerie biOmédicale MultimodAle Paris-Saclay Service d'Ingénierie Moléculaire pour la Santé (ex SIMOPRO)
• Publié dans Journal of the American Society of Nephrology le 26/10/2020

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Résumé : Background: Vaptans were developed at the end of the previous century as V2R antagonists. Tolvaptan is the most prescribed vaptan for hyponatremia and the autosomal polycystic kidney disease (ADPKD). However, its use is not as widespread as it should be due to price issues, a narrow therapeutic window and some side effects. With the aim of discovering new efficient and safer V2R antagonists, we screened animal venoms and identified several interesting peptide toxins. Among them, MQ1 displayed such unique biological properties in that regard that it was the starting point for the development of a potential drug candidate. Methods: Human T-cell assays and bioinformatics was used to mitigate MQ1 immunogenicity risk. The MQ232 biodistribution in mice was done by positron emission tomography (PET). Pharmacodynamics, pharmacokinetics, acute and chronic toxicity tests were performed on control rats. A rat experimental model of dDAVP-induced hyponatremia, an ex vivo mice model of renal cysts and a mice orthologous model of ADPKD were used to validate MQ232 efficacy in these pathologies. Results: Three mutations were introduced in MQ1 to mitigate its immunogenicity risk. A fourth gain-of-function mutation was added to generate MQ232. MQ232's safety was demonstrated by a first toxic dose as high as 3,000 nmol/kg and a strong kidney organ selectivity by PET imaging, while showing almost no interaction with the liver. MQ232's efficacy was first demonstrated with an effective dose of 3 nmol/kg in a hyponatremic model, and then in polycystic kidney models on which MQ232 significantly reduced cyst growth. Conclusions: We demonstrated, employing diverse translational techniques and minimizing animal use, MQ232's safety and efficacy in several rodent models of hyponatremia and ADPKD.

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Fichiers liés : Stanajic-Petrovic et al 2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2025
• Auteurs : Thomas BallulVito SabatoPeter ValentOlivier HermineOlivier LortholaryJulien RossignolThomas BallulVito SabatoCristina Bulai LivideanuAntoine NeurazJulie AgopianFabienne BrenetPatrice DubreuilDidier EboMichiel BeyensRichard LemalOlivier TournilhacLouis TerriouDavid LaunayLaurence BouilletCatharina ChatainClément GourguechonGandhi DamajStéphane DuruptCeline GrecoLaurent FrenzelChristine Bodemer-SkandalisLaura PolivkaMarine MadrangeCécile MeniHassiba BouktitAnne Florence BellaisJean-Marc DurandMarie GousseffEdwige Le MouelMohamed HamidouAntoine NéelDana RantaMathilde NiaultAurélie SchiffmannStéphane BareteMichel ArockDanielle CanioniThierry Jo MolinaJulie BruneauMélanie VaesViolaine HavelangeHassan FaourNicolas GarcelonRose-Marie JavierFabien PelletierFlorence CastelainDenis VincentFrédérique RetornazQuentin CabreraPatricia ZunicPhilippe GuilpainMarie Pierre GourinJean-François ViallardChristian LavigneCyrille HoarauLudovic LhermitteMaël HeibligRoland JaussaudPeter ValentOlivier HermineOlivier LortholaryJulien Rossignol
• Organismes : Translational Research in Autoimmunity and Inflammation Group
• Publié dans EClinicalMedicine le 01/11/2020

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