Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 11/09/2024
• Auteurs : Antoine CormanMarie-Liesse LouvetMagali LugnotMarie GoudotMarc MalcorAnne Le MaîtreJean-Pierre LemairePierre MrdjenovicJulia CastiglionePascal DethurensDidier PourqueryAnne BaudartPierre CharreyClarisse TessonPascale GrusonOury GoldmanGildas LabeyClément BreschJoseph MailaOlivia LeboyerAlexei GrinbaumJean-Philippe PierronMichel Fédou
• Organismes : Laboratoire des Recherches sur les Sciences de la Matière
• Publié dans Études : revue de culture contemporaine le 26/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 11/09/2024
• Auteurs : Alice DejouxQianqian ZhuChristelle GanneauOdile Richard Le GoffOphélie GodonJulien LemaitreFrancis RelouzatFrançois HuetzAurélien SokalAlexis VandenbergheCyprien PecalvelLise HunaultThomas DerenneCaitlin GillisBruno IannascoliYidan WangThierry RoseChristel MertensPascale Nicaise-RolandPatrick EnglandMatthieu MahévasLuc de ChaisemartinRoger Le GrandHélène LetscherFrederick SaulCédric PissisAhmed HaouzLaurent ReberPascal ChappertFriederike JönssonDidier G. EboGael A. MillotSylvie BaySylvie Chollet-MartinAurélie Gouel-CheronPierre BruhnsDavid MancardiVanessa GrangerDan LongroisPhilippe MontraversCaroline SauvanMichel AubierCatherine NeukirchFadia DibCatherine Paugam-BurtzSkander NecibHawa Keita-MeyerValentina FaitotAlexandre MebazaaMatthieu Le DorzeBernard CholleyJean MantzOlivier LangeronSabrine RocheLaurent JacobBenoit PlaudJulie BressonCarole ChahineMarc FischlerMarie-Thérèse GuinnepainFlorence TubachAntoine Mignon
• Organismes : Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Collège Doctoral Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Inflammation, microbiome, immunosurveillance Chimie des Biomolécules - Chemistry of Biomolecules Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Commissariat à l'énergie atomique et aux énergies alternatives Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Commissariat à l'énergie atomique et aux énergies alternatives Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Institut Necker Enfants-Malades Université Paris-Est Créteil Val-de-Marne - Paris 12 Institut Mondor de Recherche Biomédicale Service de médecine interne Institut Necker Enfants-Malades Université Paris-Est Créteil Val-de-Marne - Paris 12 Institut Mondor de Recherche Biomédicale Institut Toulousain des Maladies Infectieuses et Inflammatoires Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Collège Doctoral Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Collège Doctoral Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Biologie Cellulaire des Lymphocytes - Lymphocyte Cell Biology Equipe labellisée Ligue contre le Cancer Antwerp University Hospital [Edegem] Universiteit Antwerpen = University of Antwerp AZ Jan Palfijn Hospital [Ghent, Belgium] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Biophysique Moléculaire (plateforme) - Molecular Biophysics (platform) Institut Necker Enfants-Malades Université Paris-Est Créteil Val-de-Marne - Paris 12 Institut Mondor de Recherche Biomédicale Inflammation, microbiome, immunosurveillance AP-HP - Hôpital Bichat - Claude Bernard [Paris] Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Commissariat à l'énergie atomique et aux énergies alternatives Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes Université Paris-Saclay Institut National de la Santé et de la Recherche Médicale Commissariat à l'énergie atomique et aux énergies alternatives Centre de recherche en Immunologie des Infections virales et des maladies auto-immunes Cristallographie (Plateforme) - Crystallography (Platform) Cristallographie (Plateforme) - Crystallography (Platform) Cristallographie (Plateforme) - Crystallography (Platform) Institut Toulousain des Maladies Infectieuses et Inflammatoires Institut Necker Enfants-Malades Université Paris-Est Créteil Val-de-Marne - Paris 12 Institut Mondor de Recherche Biomédicale Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Centre National de la Recherche Scientifique Antwerp University Hospital [Edegem] Universiteit Antwerpen = University of Antwerp AZ Jan Palfijn Hospital [Ghent, Belgium] Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB Chimie des Biomolécules - Chemistry of Biomolecules Inflammation, microbiome, immunosurveillance AP-HP - Hôpital Bichat - Claude Bernard [Paris] Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology AP-HP - Hôpital Bichat - Claude Bernard [Paris] Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology Physiopathologie et Epidémiologie des Maladies Respiratoires Laboratoire d'excellence Inflamex [site Bichat] Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology
• Publié dans Science Translational Medicine le 23/10/2020

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Résumé : Neuromuscular blocking agents (NMBAs) relax skeletal muscles to facilitate surgeries and ease intubation but can lead to adverse reactions, including complications because of postoperative residual neuromuscular blockade (rNMB) and, in rare cases, anaphylaxis. Both adverse reactions vary between types of NMBAs, with rocuronium, a widely used nondepolarizing NMBA, inducing one of the longest rNMB durations and highest anaphylaxis incidences. rNMB induced by rocuronium can be reversed by the synthetic γ-cyclodextrin sugammadex. However, in rare cases, sugammadex can provoke anaphylaxis. Thus, additional therapeutic options are needed. Rocuronium-induced anaphylaxis is proposed to rely on preexisting rocuronium-binding antibodies. To understand the pathogenesis of rocuronium-induced anaphylaxis and to identify potential therapeutics, we investigated the memory B cell antibody repertoire of patients with suspected hypersensitivity to rocuronium. We identified polyclonal antibody repertoires with a high diversity among V(D)J genes without evidence of clonal groups. When recombinantly expressed, these antibodies demonstrated specificity and low affinity for rocuronium without cross-reactivity for other NMBAs. Moreover, when these antibodies were expressed as human immunoglobulin E (IgE), they triggered human mast cell activation and passive systemic anaphylaxis in transgenic mice, although their affinities were insufficient to serve as reversal agents. Rocuronium-specific, high-affinity antibodies were thus isolated from rocuronium-immunized mice. The highest-affinity antibody was able to reverse rocuronium-induced neuromuscular blockade in nonhuman primates with kinetics comparable to that of sugammadex. Together, these data support the hypothesis that antibodies cause anaphylactic reactions to rocuronium and pave the way for improved diagnostics and neuromuscular blockade reversal agents.

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Fichiers liés : Combined_pdf_no_marks.pdf

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• Type de publi. :
• Date de publi. : 11/09/2024
• Auteurs : Jean MainguyMaïna VienneJoanna FourquetPierre MartinVincent DarbotCéline NoirotPhilippe RuizGéraldine PascalClaire Hoede
• Organismes : Unité de Mathématiques et Informatique Appliquées de Toulouse Plateforme Bio-Informatique - Génotoul Plateforme Bio-Informatique - Génotoul Unité de Mathématiques et Informatique Appliquées de Toulouse Unité de Mathématiques et Informatique Appliquées de Toulouse Génétique Physiologie et Systèmes d'Elevage Plateforme Bio-Informatique - Génotoul Plateforme Bio-Informatique - Génotoul Unité de Mathématiques et Informatique Appliquées de Toulouse Génétique Physiologie et Systèmes d'Elevage Plateforme Bio-Informatique - Génotoul Unité de Mathématiques et Informatique Appliquées de Toulouse IR BioInfOmics Plateforme Bio-Informatique - Génotoul Unité de Mathématiques et Informatique Appliquées de Toulouse Génétique Physiologie et Systèmes d'Elevage Plateforme Bio-Informatique - Génotoul Unité de Mathématiques et Informatique Appliquées de Toulouse

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Résumé : metagWGS is a workflow dedicated to the analysis of metagenomic data. It allows assembly, taxonomic annotation, and functional annotation of predicted genes. Since release 2.3, binning step with the possibility of cross-alignment is included. It has been developed in collaboration with several CATI BIOS4biol agents. Funded by Antiselfish Project (Labex Ecofect), ExpoMicoPig project (France Futur elevage) and SeqOccIn project (CPER - Occitanie Toulouse / FEDER), ATB_Biofilm funded by PNREST Anses, France genomique (ANR-10-INBS-09-08) and Resalab Ouest.

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Fichiers liés : metagwgs-v2.4.2.zip

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• Type de publi. :
• Date de publi. : 10/09/2024
• Auteurs : Lucie ThomasLaurence CuissetJean-François PaponAline TamaletIsabelle PinRola Abou TaamCatherine FauconGuy MontantinSylvie TissierPhilippe DuquesnoyFlorence Dastot - Le MoalBruno CopinNathalie CarionBruno LouisSandra Chantot-BastaraudJean-Pierre SiffroiRana MitriAndré CosteEstelle EscudierGuillaume ThouveninSerge AmselemMarie Legendre
• Organismes : Maladies génétiques d'expression pédiatrique AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Institut Mondor de Recherche Biomédicale Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] CHU Trousseau [APHP] Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire [CHU Grenoble] CHU Trousseau [APHP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Institut Mondor de Recherche Biomédicale CHU Trousseau [APHP] CHU Trousseau [APHP] Centre Hospitalier Intercommunal de Créteil Institut Mondor de Recherche Biomédicale Centre Hospitalier Intercommunal de Créteil CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Maladies génétiques d'expression pédiatrique

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Résumé : Background. Primary ciliary dyskinesia (PCD) is a rare airway disorder caused by defective motile cilia. Only male patients have been reported with pathogenic mutations in X-linked DNAAF6, which result in the absence of ciliary dynein arms, whereas their heterozygous mothers are supposedly healthy. Our objective was to assess the possible clinical and ciliary consequences of X-chromosome inactivation (XCI) in these mothers. Methods. XCI patterns of 6 mothers of male patients with DNAAF6-related PCD were determined by DNA-methylation studies and compared to their clinical phenotype (6/6 mothers), as well as their ciliary phenotype (4/6 mothers), as assessed by immunofluorescence and high-speed videomicroscopy analyses. The mutated X chromosome was tracked to assess the percentage of cells with a normal inactivated DNAAF6 allele. Results. The mothers’ phenotypes ranged from absence of symptoms to mild/moderate or severe airway phenotypes, closely reflecting their XCI pattern. Analyses of the symptomatic mothers’ airway ciliated cells revealed the coexistence of normal cells and cells with immotile cilia lacking dynein arms, whose ratio closely mirrored their XCI pattern. Conclusion. This study highlights the importance of searching for heterozygous pathogenic DNAAF6 mutations in all female relatives of male PCD patients with a DNAAF6 defect, as well as in females consulting for mild chronic respiratory symptoms. Our results also demonstrate that about one third - ranging from 20-50% - normal ciliated airway cells sufficed to avoid severe PCD, a result paving the way for gene therapy.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2024
• Auteurs : Sergey KhaykinAlain HauchecornePhilippe KeckhutJ.-P. CammasMathieu RatynskiRobin WingSamuel TrémoulouFabrice Chane Ming
• Organismes : STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS Observatoire des Sciences de l'Univers de La Réunion STRATO - LATMOS Rosenstiel School of Marine and Atmospheric Science Leibniz-Institute of Atmospheric Physics STRATO - LATMOS Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones

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Résumé : Vertically-resolved measurements of wind velocity in the middle atmosphere are essential for understanding the global circulation driven by dynamical processes such as gravity and planetary waves interacting with the atmospheric flow. While weather balloon soundings provide regular observations of horizontal wind profiles up to about 30 km altitude, the layer between 30 – 60 km altitude, the so called “radar gap” is poorly covered by observations. The only information on the wind field in this layer available on the regular basis is inferred from horizontal pressure gradients derived from space-borne temperature measurements using geostrophic balance assumption however this does not allow characterizing regional-scale dynamical processes. Here we present Rayleigh-Mie wind lidar, measuring Doppler shift between the emitted and backscattered light by means of a Fabry-Perot interferometer. The wind lidars are deployed at Observatory of Haute-Provence (OHP, Southern France) and at Maido observatory in Reunion Island (tropical Indian Ocean). The instruments are capable of measuring horizontal wind components from the middle troposphere up to 75 km altitude with vertical resolution as high as 100 m and temporal resolution down to 5 minutes. Both lidars have been operated quasi-continuously since 2019 thus providing the first multi-year vertically-resolved time series of wind velocity in the northern midlatitudes and southern tropics. In this study, we present and discuss various scientific applications of the wind lidar observations. We report examples of a weekly and an hourly observation series, reflecting various dynamical events in the middle atmosphere, such as a Sudden Stratospheric Warming events and occurrence of orographic and non-orographic gravity waves. Wind velocity profiles are analysed in conjunction with temperature lidar profiling, radiosoundings, satellite observations as well as meteorological analysis/reanalysis in order to characterize gravity waves and their vertical propagation and filtering. Finally, we present a summary of results of the ESA Aeolus space-borne wind lidar validation using its ground-based predecessor in the frame of a series of dedicated campaigns at both observatories.

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• Type de publi. : Article dans une revue
• Date de publi. : 09/09/2024
• Auteurs : Laetitia GayValérie Desquiret-DumasNicolas NagotClara RapennePhilippe van de PerrePascal ReynierJean‐pierre Molès
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Pathogenesis and Control of Chronic and Emerging Infections Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Journal of Medical Virology le 25/10/2020

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Résumé : Mitochondria are vital for most cells' functions. Viruses hijack mitochondria machinery for misappropriation of energy supply or to bypass defense mechanisms. Many of these mitochondrial dysfunctions persist after recovery from treated or untreated viral infections, particularly when mitochondrial DNA is permanently damaged. Quantitative defects and structural rearrangements of mitochondrial DNA accumulate in post‐mitotic tissues as recently reported long after SARS‐CoV‐2 or HIV infection, or following antiviral therapy. These observations are consistent with the “hit‐and‐run” concept proposed decades ago to explain viro‐induced cell transformation and it could apply to delayed post‐viral onsets of symptoms and advocate for complementary supportive care. Thus, according to this concept, following exposure to viruses or antiviral agents, mitochondrial damage could evolve into an autonomous clinical condition. It also establishes a pathogenic link between communicable and non‐communicable chronic diseases.

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Fichiers liés : Journal of Medical Virology - 2024 - Gay - Long‐term persistence of mitochondrial dysfunctions after viral infections and.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 09/09/2024
• Auteurs : Liss LudivineYanis AbdedouRuiling WengPierre JeunesseChristophe HecquetFlorence Fuchs-NogrettePhilippe DelayeMondher BesbesJérôme SalviJean-Charles BeugnotSylvie Lebrun
• Organismes : Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Laboratoire Charles Fabry / Photonique Non Linéaire Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Laboratoire Charles Fabry / Photonique Non Linéaire

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Résumé : We present measurements of the temperature of optical microfibers self-heated by a cw laser emitting at 1.48 μm. The experimental method we have implemented is simple and enables to perform for the first time to our knowledge spatially distributed measurements along the tapers and the microfiber part. Temperature rise of more than 20 °C is measured for moderate powers (200 mW) and relatively large radii (1.45 μm). The results are confronted to a numerical model we have developed and enable to determine range of values for the couple thermal transfer coefficient/surface absorption coefficient.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/09/2024
• Auteurs : Ryma BenrabahÉmilien GirotPhilippe ArnouxJean-Marc CommengeRené FournetPierre-Alexandre GlaudeBaptiste Sirjean
• Organismes : Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés Laboratoire Réactions et Génie des Procédés

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Résumé : One potential solution to diminish the aviation carbon footprint is to blend Sustainable Aviation Fuel (SAF) into jet fuels. However, the thermal stability and oxidation stability of standard jetfuels may be affected by the addition of SAF 1 . In this context, we developed a Si-glass microfluidic reactor with a fluid supply made of inert polyether ether ketone (PEEK). The experimental rig PEEK-ACHU (Autoxidation µChip Heated Unit) was used to investigate the oxidation stability of a SAF surrogate and the results were compared to Induction Period (IP) measures, obtained in a standard PetroOxy device. A mixture of n-decane and iso-octane was used as the surrogate SAF 2 . The thermal oxidation stability of the mixtures was measured in the microreactor, working at conditions up to 453 K and 30 bar, with a gas-liquid segmented flow that allows the liquid oxidation to occur in homogeneous, self-agitated liquid slugs. PEEK-ACHU enables residence times as long as 3.8 hours to be reached on a 4-inch diameter Si/glass wafer, visual access to the reactor, and a well-defined kinetic study of the liquid fuel autoxidation. The total hydroperoxide (ROOH) concentration was quantified at the exit of the microreactor using a specifically designed HPLC device with a post-column reactor 3 . For comparison, the same analysis was conducted on the SAF oxidized in the PetroOxy apparatus, with the same residence time. The results of this study show that the microfluidic apparatus is able to perform reliable autoxidation measurements and allows a better understanding of the kinetics. The self-stirring ensures a homogenous phase, and the visual access of the reactor is relevant for other applications, such as spectroscopic monitoring of deposit formation.

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Fichiers liés : IASH 2024_Bacha_ Benrabah_vf.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/09/2024
• Auteurs : Sélim Ben ChéhidaHeemee Devi BunwareeMurielle HoareauOumaima MoubsetCharlotte JulianLaurence BlondinDenis FillouxChristophe LavergnePhilippe RoumagnacArvind VarsaniDarren MartinJean Michel LettPierre Lefeuvre
• Organismes : Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Conservatoire Botanique National de Mascarin Plant Health Institute of Montpellier Arizona State University [Tempe] University of Cape Town University of Cape Town Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical

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Résumé : The geographical distribution and diversity of viruses can differ between cultivated areas and adjacent natural environments, raising questions about the interplay between plant diversity and the species richness and prevalence of the phytoviruses. As both the amplification and the dilution of viral species richness due to increasing host diversity have been theorized and observed, a deeper understanding of how plant-viruses interact in natural environments is needed to explore how host availability conditions viral diversity and distributions. This study explores interactions of viruses from the Mastrevirus genus (family Geminiviridae) with hosts from the Poaceae family across ten sites from three contrasting ecosystems on La Réunion. Among 273 plant pools, representing 61 Poales species, 15 Mastrevirus species were characterized from 22 hosts. We find a strong association of mastreviruses with hosts from agro-ecosystems and the absence of mastreviruses in subalpine areas, dominated by native plants. This suggests that all detected mastreviruses likely originated from viruses introduced through agricultural activities rather than being native to La Réunion. Analyses of the structure of the host plant-mastrevirus interaction network revealed a pattern of increasing viral richness with increasing host richness. Accounting for variations in the diversity of hosts across sites, we observed increasing viral niche occupancies with increasing host species richness. Virus realized richness at any given site is conditioned on the global capacity of the plant populations to host diverse mastreviruses. Whether this tendency is driven by synergy between viruses, or by an interplay between vector population and plant richness, remains to be established.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/09/2024
• Auteurs : Marion FilliâtreSeda SerenAnge Embo-IbouangaJean-Patrick JolyVéronique BouchaudInes KelkoulSylvain MarqueGérard AudranPierre VoisinPhilippe Mellet
• Organismes : Institut de Chimie Radicalaire Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Institut de Chimie Radicalaire Institut de Chimie Radicalaire Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques
• Publié dans ACS Omega le 23/10/2020

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Fichiers liés : Filliâtre et al. - 2024 - Intrinsic Proteolytic Activities from Cancer Cells.pdf

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