Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Frédérique Pénault-LlorcaClarisse Audigier-ValettePierre-Jean LamyDominique Stoppa LyonnetPhilippe CamparoSophie BeaupèreXavier TroussardLaure Gueroult AccolasGérard RaymondAlexandre AudayJean-Yves BlayFrançois Sarkozy
• Organismes : Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand]
• Publié dans Bulletin du Cancer le 01/11/2020

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Résumé : The prognostic of certain cancers improved significantly in recent years thanks not only to the launch of innovative treatments but also to progress made in the diagnostic field. Thus, next-generation sequencing (NGS) became paramount to help characterizing tumors and selecting the most pertinent treatments. The survey conducted by a multi stakeholder committee, at the end of 2022, with 103 actors of the management of cancer patients (public and private centers, labs, prescribers, biologists, pathologists, direction) confirmed the heterogeneity of use of NGS tests across France due to, mainly, the lack of systematic reimbursement of related costs. Référentiel des actes innovants hors nomenclature de biologie (RIHN) covers, in a delayed and partial way, only half of costs engaged by centers. Only those with a critical mass of patients or with a sufficient funding capacity can guarantee an access to large panels. Postponing the initiation of a required treatment represents a risk of loss of opportunity for patients who cannot benefit of this technology. NGS large panels tests, an efficiency lever for cancer treatment, must be part of the care toolbox. Those with a demonstration of value created should nowadays be fully reimbursed by collectivity after HAS' evaluation, for a fair access throughout the territory. Precision diagnostic can open the way to a more personalized and efficient medicine.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Vincent Moya QuirosAhmed AdhamPhilippe ConversGaëtan LescaFrançois MauguièreHugo SoulierAlexis ArzimanoglouAllan BayatHilde BraakmanJean-Philippe CamdessanchéPhilippe CasenaveLaurence ChatonYves ChaixMaxime ChochoiChristel DepienneVincent Des PortesJessie de RidderVera DinkelackerElena GardellaGerhard KlugerJulien JungMartine Lemesle MartinMaria Margherita MancardiMarkus MuellerAnne-Lise PoulatKonrad PlatzerAgathe RoubertieMarijn F StokmanAnneke T Vulto‐van SilfhoutGert WiegandLaure Mazzola
• Organismes : Service de Neurologie [CHU de Saint-Étienne] Service de Médecine Physique et de Réadaptation [CHU Saint-Etienne] Clinatec - Centre de recherche biomédicale Edmond J.Safra Service de Neurologie [CHU de Saint-Étienne] Équipe Intégration Centrale de la Douleur chez l'Homme - Central Integration of Pain in Human Team Institut de Cancérologie des Hospices Civils de Lyon Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Équipe Intégration Centrale de la Douleur chez l'Homme - Central Integration of Pain in Human Team Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Service de Neurologie [CHU de Saint-Étienne] Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Hospital Sant Joan de Déu [Barcelona] Institute for Regional Health Services [Odense] The Danish Epilepsy Centre [Dianalund] Københavns Universitet = University of Copenhagen = Université de Copenhague Rigshospitalet [Copenhagen, Denmark] Radboud University Medical Center [Nijmegen] Service de Neurologie [CHU de Saint-Étienne] Centre Hospitalier Libourne Département de neurologie [Lille] Toulouse NeuroImaging Center Service Neurologie Pédiatrique [CHU Toulouse] Département de neurologie [Lille] Universität Duisburg-Essen = University of Duisburg-Essen [Essen] Hôpital Femme Mère Enfant [HCL] Academic Center for Epileptology Kempenhaeghe & Maastricht UMC+ [Heeze] Service de Neurologie [Strasbourg] Institute for Regional Health Services [Odense] The Danish Epilepsy Centre [Dianalund] Auteur indépendant Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Neurosciences de l’Expérience Subjective et Entraînement Mental - Experiential Neuroscience and Mental Training Service de Neurophysiologie Clinique (CHU Dijon) Istituto Giannina Gaslini, Genova Universität Bielefeld = Bielefeld University Hôpital Femme Mère Enfant [HCL] University Hospital Leipzig = Universitätsklinikum Leipzig Hôpital Gui de Chauliac [CHU Montpellier] Radboud University Medical Center [Nijmegen] Radboud University Medical Center [Nijmegen] Asklepios Klinikum Harburg [Hamburg, Germany] University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein Service de Neurologie [CHU de Saint-Étienne] Équipe Intégration Centrale de la Douleur chez l'Homme - Central Integration of Pain in Human Team
• Publié dans Annals of Neurology le 26/10/2020

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Résumé : Objective: There is currently scarce data on the electroclinical characteristics of epilepsy associated with synapsin 1 (SYN1) pathogenic variations. We examined clinical and electro-encephalographic (EEG) features in patients with epilepsy and SYN1 variants, with the aim of identifying a distinctive electroclinical pattern. Methods: In this retrospective multicenter study, we collected and reviewed demographic, genetic, and epilepsy data of 19 male patients with SYN1 variants. Specifically, we analyzed interictal EEG data for all patients, and electro-clinical data from 10 epileptic seizures in 5 patients, using prolonged video-EEG monitoring recordings. Inter-ictal EEG functional connectivity parameters and frequency spectrum of the 10 patients over 12 years of age, were computed and compared with those of 56 age- and sex-matched controls. Results: The main electroclinical features of epilepsy in patients with SYN1 were (1) EEG background and organization mainly normal; (2) interictal abnormalities are often rare or not visible on EEG; (3) more than 60% of patients had reflex seizures (cutaneous contact with water and defecation being the main triggers) isolated or associated with spontaneous seizures; (4) electro-clinical semiology of seizures was mainly temporal or temporo-insulo/perisylvian with a notable autonomic component; and (5) ictal EEG showed a characteristic rhythmic theta/delta activity predominating in temporo-perisylvian regions at the beginning of most seizures. Comparing patients with SYN1 to healthy subjects, we observed a shift to lower frequency bands in power spectrum of interictal EEG and an increased connectivity in both temporal regions. Interpretation: A distinct epilepsy syndrome emerges in patients with SYN1, with a rather characteristic clinical and EEG pattern suggesting predominant temporo-insular involvement. ANN NEUROL 2024.

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Fichiers liés : Moya Quiros_2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Olivier FogelDamien Caillet-PortilloAurélie NajmAthan BailletPascal ClaudepierreOrnella ConortEmmanuelle DernisFrançoise FayetLaure GossecPhilippe GoupilleChristophe HudryJean-Guillaume LetarouillyCédric LukasHubert MarotteAnna MoltoSophie PouplinEric SenbelChristelle SordetAnne TournadreMarie-Elise TruchetetDaniel WendlingAdeline Ruyssen-WitrandMaxime Dougados
• Organismes : AP-HP - Hôpital Cochin Clinical Epidemiology Applied to Osteoarticular Diseases | Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques Centre Hospitalier Universitaire de Toulouse University of Glasgow Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 AP-HP - Hôpital Henri-Mondor AP-HP - Hôpital Cochin Centre Hospitalier Le Mans (CH Le Mans) CHU Clermont-Ferrand Institut Pierre Louis d'Epidémiologie et de Santé Publique AP-HP - Hôpital de la Pitié Salpêtrière Nanomédicaments et Nanosondes Centre Hospitalier Régional Universitaire de Tours Institut Mutualiste de Montsouris Centre Hospitalier Régional Universitaire [CHU Lille] Institut Desbrest d'Epidémiologie et de Santé Publique U 1059 – SAINBIOSE Bio-ingénierie AP-HP - Hôpital Cochin Clinical Epidemiology Applied to Osteoarticular Diseases | Épidémiologie clinique appliquée aux maladies rhumatismales et musculo-squelettiques CHU Rouen Centre Hospitalier Universitaire [Strasbourg] Université Clermont Auvergne Service Rhumatologie [CHU Clermont-Ferrand] Unité de Nutrition Humaine Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle Agents pathogènes et inflammation - UFC (EA 4266) Centre d'investigation clinique de Toulouse Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques AP-HP - Hôpital Cochin
• Publié dans Revue du Rhumatisme le 29/10/2020

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Résumé : Introduction: National and international recommendations call for an annual standardized systematic holistic review in the management of chronic inflammatory rheumatism (CIR). This includes an assessment of disease activity and severity, as well as patient education on the disease, knowledge of pharmacological and non-pharmacological treatments, adherence to treatment and screening for comorbidities. Our study aims to recall the definition of a holistic review (HR), to present the evidence of their effectiveness and to give an overview of HR practices in France. Methods: A literature review was conducted in the Pubmed database to identify randomized controlled trials (RCTs) or meta-analyses reporting the efficacy of a multidisciplinary intervention in ICR or other chronic diseases. Two online surveys were sent to all rheumatology departments in France and to a sample of independent rheumatologists, with 34 and 19 questions respectively. These questionnaires were used to determine the profile of the responding center/rheumatologist, the existence of an HR and the obstacles or facilitators to its implementation. Results: Literature search yielded 872 articles, 24 of which were finally included: 16 RCTs and 8 meta-analyses. Only 3 articles concerned ICRs, including one meta-analysis of 10 RCTs in rheumatoid arthritis (RA). Of these 3 studies, 2 RCTs in systemic lupus and systemic sclerosis showed a favorable impact of a multidisciplinary approach on SLEDAI and grip strength and mouth opening respectively, while the meta-analysis in RA showed no benefit on disability or disease activity. The questionnaire was answered by 72 centers and 186 rheumatologists. A third of the centers had already implemented a HR during a day hospitalization. Seventy percent of centers estimated that they managed more than 10 patients per month, devoting an average of 35 minutes of rheumatologist time and 90 minutes of cumulative time for all other healthcare professionals (HCPs) involved in the program. Most of the HCPs involved were nurses (92%), dieticians (56%) and physiotherapists (56%). The main obstacles to setting up a HR were the lack of paramedical resources, lack of economic value and lack of support from treating rheumatologists, while patient motivation was seen as a facilitating factor. Conclusion: Although HR is recommended, there is little evidence of its effectiveness in ICR. Only 36% of responding centers have implemented such a program. This survey helps to identify the obstacles and facilitators, and to find solutions for extending this practice.

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Fichiers liés : ImmunoConcept_Revue_de_Rhumatisme_2025_Fogel.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Mathilde LefortOlivier DejardinEric BergerJean-Philippe CamdessanchéJonathan CironPierre ClavelouJerome de SèzeMarc DebouverieOlivier HeinzlefPierre LabaugeDavid-Axel LaplaudLaure MichelChristine Lebrun-FrenayThibault MoreauJean PelletierAurélie RuetEric ThouvenotSandra VukusicHélène ZéphirGilles DeferEmmanuelle Leray
• Organismes : École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut Toulousain des Maladies Infectieuses et Inflammatoires CHU Clermont-Ferrand Neuro-Dol CIC Strasbourg Adaptation, mesure et évaluation en santé. Approches interdisciplinaires Service de neurologie [CHRU Nancy] Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye CHU Montpellier = Montpellier University Hospital Université de Montpellier Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital de la Timone [CHU - APHM] Centre d'Investigation Clinique [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Hôpital Universitaire Carémeau [Nîmes] Institut de Génomique Fonctionnelle Hospices Civils de Lyon Observatoire Français de la Sclérose En Plaques [Lyon] Université Claude Bernard Lyon 1 Fondation Eugène Devic EDMUS Lille Neurosciences & Cognition - U 1172 Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre d'Investigation Clinique [Rennes] Département Méthodes quantitatives en santé publique École des Hautes Études en Santé Publique Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé
• Publié dans Multiple Sclerosis Journal le 31/10/2020

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Résumé : Background: We hypothesized that differences in access to disease-modifying treatments (DMTs) could explain the association between socioeconomic status and disability progression in multiple sclerosis (MS). Objective: This study aimed to analyze the association between education level and DMT use in France. Methods: All patients from OFSEP network with MS onset over 1996–2014 and aged ⩾ 25 years at onset were included. Three time-to-event outcomes were investigated using flexible parametric survival regression models: time from MS onset to first DMT (any) and to platform therapy, and time from platform therapy to switch to high-efficacy therapy. Results: Overall, 7563 patients were included (mean follow-up 12.6 ± 5.9 years). The percentages of patients aged less than 40 years at MS onset and who initiated treatment before the age of 40 years were significantly higher in the groups with a higher education level. The time-to-event outcomes showed no major difference in DMT practices according to education level, except for women who had a significantly shorter time to DMT initiation in medium to very high education level groups versus low, at 5 years from MS clinical onset. Conclusion: Our results suggest that the association between education level and MS disability progression does not solely reflect different therapeutic practices, particularly in men.

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Fichiers liés : Lefort - 2024 - Association between education level and access to disease-modifying treatment _Manuscript_Education&Treatment Leray MSJ pour HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Rodrigue GarciaFawzi KerkouriChristelle MarquiéMouna Ben KilaniHugues BlangyGaël ClericiRomain EschalierFabrice ExtramianaBenoît Guy-MoyatAlexis HermidaJérôme HourdainPeggy JaconChristophe LeclercqPhilippe MauryPierre OllitraultJean-Luc PasquiéBertrand PierreVincent ProbstSerge BovedaEloi Marijon
• Organismes : Service de cardiologie [CHU de Poitiers] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Hôpital de la Cavale Blanche - CHRU Brest Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Centre Hospitalier Universitaire d'Angers Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de cardiologie [CHU La Réunion] Service Chirurgie Cardio-Vasculaire [CHU Clermont-Ferrand] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases AP-HP - Hôpital Bichat - Claude Bernard [Paris] Service de cardiologie [CHU Limoges] Service de Cardiologie [Amiens] HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Service de cardiologie Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Département de cardiologie [CHU de Grenoble] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Service Chirurgie Cardio-Vasculaire [CHU Toulouse] Service Cardiologie pédiatrique [CHU Toulouse] Service de cardiologie et de pathologie vasculaire [CHU Caen] Service de Médecine du Sport [CHU CAEN] Service de Chirurgie thoracique et cardio-vasculaire [CHU Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours PHU 2 - Institut du Thorax et du Sytème Nerveux [CHU Nantes] Clinique Pasteur [Toulouse] Service de cardiologie [Clinique Pasteur - Toulouse] AP-HP - Hôpital Européen Georges Pompidou Paris-Centre de Recherche Cardiovasculaire
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Introduction While the subcutaneous implantable cardioverter defibrillator (S-ICD) is now an established strategy to prevent sudden cardiac death, the specificities and outcomes associated with the use of this device in women have never been assessed so far. Objective The present study aimed to provide contemporary real-world data on S-ICD use and outcomes in women. Method We used data from the HONEST cohort, a nationwide study including all patients implanted with a S-ICD between 2012 and 2019 in France. Sex-specific outcomes were acceded using a weighting propensity score analysis. Results A total of 1148 women (47.3 ± 15.6 years), accounting for 23.3% of the whole cohort (n = 4924), were enrolled. Indication of implantation was primary prevention in 57.6% (vs. 65.1% in men) and secondary prevention in 42.4% (vs. 34.9% in men; P < 0.009). Coronary artery disease was the most frequent underlying heart disease (38.9% vs. 56.5% in men) and electrical heart disorders were more common in women (26.4% vs. 20.5%; P < 0.001). During a mean follow up of 4.22 ± 2.18 years, women did not have a higher risk of overall complications (aHR 0.95; 95%CI 0.89–1.01; P = 0.065), and of surgical reintervention (aHR 0.95, 95%CI 0.89–1.02, P = 0.094) (Fig. 1). Re-intervention due to pacing need occurred similarly in both sexes (2.4% vs. 2.8%; P = 0.434). Conversely, the risk of inappropriate (aHR 0.81; 95% 0.71–0.91; P < 0.001) and appropriate shocks (aHR 0.91; 95%CI 0.82–1.00; P = 0.045) was lower in women. Finally, there was no difference in risk of death between genders (aHR 1.00; 95%CI 0.97–1.02; P = 0.790). Conclusion This nationwide multicenter cohort study of S-ICD patients showed significant sex-related differences in patient characteristics and outcomes, with a lower risk of appropriate and inappropriate shocks in women as compared with men.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Nicola VeroneseMaria Cristina PolidoriStefania MaggiJavier ZamoraGabriel Ruiz-CalvoMathieu BangertPierre BourronAnnika BauschJuan Dionisio Avilés-HernándezAlfonso López-SotoDaniel Padrón GuillénJ.P. LanoixAlfonso Cruz-JentoftGaëtan GavazziLena PickertClara LehmannChristine von ArnimChristoph FriedrichAlberto PilottoRomina CustureriSimone DiniRosetta FemiaFrancesca TricerriMargherita AzziniFrancesco SpeltaPaolo BertasselloNicola VeroneseMario BarbagalloFrancesco Saverio RagusaLuisa SolimandoRoberta MasnataEleonora SantangeloRoberta BonicaOttavia TuloneCarlo CustoderoDario ConteArianna AntonacciLuca RizzoGaetano SguraFrancesco BolzettaFlavio BusoneraStefano GrandessoCarraro SaraLa Rosa GiovanniBolzonella SandroGiovanni RuotoloAlberto CastagnaRosa Paola CerraLaura GrecoCarmen RubertoVirginia BoccardiPatrizia MecocciEmma Giulia TravagliniEmanuela SciaccaSara ErcolaniAntonella RepettoFilippo AllegrucciGiovanni CenderelloMarco BerrutiKatiuscia SciolèAbd-El-Rachid MahmoudiMarc PaccalinSaber TouatiBertrand FougèreSarah Laurent BadrSarah BoulahrouzAymric KisserliSoraya SabeurArthur FourmyCarole GrandElodie EdwigePauline Caraux PazSylvain DiamantisEmmanuel ForestierMarion Le MarechalCyprien ArlaudMeryl DodgeAurora Rexach-CanoPaula León-NuñezMario Domínguez-RodríguezDesiree Gijón-CorderoBartolomé Garcia-PerezElisa Garcia -VázquezAychel Elena Roura-PilotoRaquel Pérez-LujanMaría del Carmen Martínez-ToldosPedro Paredes-ReyesAntonio Mateo-LópezNicolas Dario Ortega-LopezFerran Masanés- ToránTania Campomanes-RobledoLaia Rosell-TuralLara Guardado-FuentesLoreto Richi-CastellanoAndrés Burillo-Pérez
• Organismes : King Saud University [Riyadh] Università degli studi di Palermo - University of Palermo University Hospital of Cologne [Cologne] National Research Council of Italy | Consiglio Nazionale delle Ricerche Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] University of Liverpool European Centre for Disease Prevention and Control [Solna, Sweden] Parcours santé systémique University Hospital of Cologne [Cologne] Universidad Católica San Antonio de Murcia Universitat de Barcelona Maladies infectieuses et tropicales [CHU Amiens] Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 University Hospital of Cologne [Cologne] Universität zu Köln = University of Cologne Center of Molecular Medicine Cologne German Centre for Infection Research Galliera Hospital Éducation Éthique Santé Centre Hospitalier Régional Universitaire de Tours
• Publié dans Clinical Microbiology and Infection le 30/10/2020

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Résumé : Objectives: To evaluate the impact of hospitalisation for infectious diseases on the Health-Related Quality of life (HRQOL), multidimensional frailty, and functioning of older patients, we conducted a longitudinal matched cohort study in four European countries. Methods: HRQOL, frailty, and functioning were assessed using validated questionnaires at inclusion, at discharge, and up to six months later (M6) in patients aged over 65 years hospitalised for severe acute respiratory or bloodstream infections, and matched controls hospitalised for non-infectious conditions. Comparative analyses employed multilevel mixed-effect linear or logistic models to assess changes from inclusion. Results: Between 2020 and 2023, 1,968 patients aged 65 to 100 years (mean: 81) were included; 1,064 (54.1%) were male and 59 (3%) were institutionalised. Of these 1,968 patients, 826 were hospitalised for infectious diseases and 1,142 for non-infectious conditions. At inclusion, EQ-5D-3L (European Quality of life 5 Dimensions and 3 Lines) scores ranged from -0.7 to 1 (full HRQOL), with a median of 0.7 across all visits and groups. Compared to controls, patients hospitalised for infectious diseases had lower scores on the Activities of Daily Living (ADL) scale (median, 4.5 vs 5.0; p=0.020) and the Instrumental Activities of Daily Living (IADL) scale (median, 3.0 vs 4.0; p<0.001). At discharge, IADL scores were lower in patients hospitalised for infectious diseases than in controls (median, 4.0 vs 5.0, p=0.003), indicating reduced functioning. The proportion of frail patients, determined by a Multidimensional Prognostic Index (MPI) score between 0.67 and 1, was significantly higher among patients hospitalised for infectious diseases (n=113/801, 14.1%) than controls (n=108/1,111, 9.7%; p=0.012). At M6, no statistically significant differences were observed between groups in changes from inclusion in HRQOL (EQ-5D-3L, p=0.436), frailty (MPI, p=0.269), and functioning (ADL, p=0.993). Conclusions: Hospitalisation for infectious diseases and non-infectious diseases or conditions had a similar impact on HRQOL in non-institutionalised older adults.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Mathilde LefortOlivier DejardinEric BergerJean-Philippe CamdessanchéJonathan CironPierre ClavelouJérôme de SèzeMarc DebouverieOlivier HeinzlefPierre M. LabaugeDavid-Axel LaplaudEmmanuelle Le PageChristine Lebrun-FrenayThibault MoreauJean PelletierAurélie RuetEric ThouvenotSandra VukusicHélène ZéphirGilles-Louis DeferEmmanuelle Leray
• Organismes : Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Département Méthodes quantitatives en santé publique Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers Service de Neurologie [CHRU Besançon] Service de Neurologie [CHU de Saint-Étienne] Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [Strasbourg] CIC Strasbourg Adaptation, mesure et évaluation en santé. Approches interdisciplinaires Service de neurologie [CHRU Nancy] Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye Université de Montpellier Centre Hospitalier Régional Universitaire [Montpellier] Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre d’Investigation Clinique de Nantes Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Centre d'épidémiologie des populations Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] CHU de Bordeaux Pellegrin [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Institut de Génomique Fonctionnelle Centre Hospitalier Universitaire de Nîmes Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Lille Neurosciences & Cognition - U 1172 Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Département Méthodes quantitatives en santé publique Centre d'Investigation Clinique [Rennes]
• Publié dans Multiple Sclerosis Journal le 31/10/2020

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Résumé : Background: Studies have reported an association between socioeconomic status and disability progression in multiple sclerosis (MS), but findings using the pre-MS individual socioeconomic status are missing. Objective: The objective was to investigate the association between education level and disability progression. Methods: All Observatoire Français de la Sclérose en Plaques (OFSEP) patients with MS clinical onset over 1960–2014, and aged ⩾25 years at MS onset were included. Education level was classified into four categories from low (primary/secondary school) to very high (master/doctoral degree). Time from MS onset to EDSS 4.0 was studied using flexible parametric survival models adjusted for age, period, and center, and stratified by phenotype (relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS)) and sex. Results: A total of 11,586 patients were included (women/men ratio = 2.5; age = 36.7 ± 8.6 years; follow-up duration 16.7 ± 9.3 years; 86.4% RMS). For women with RMS, the risk of reaching the outcome at 5 years was inversely associated with the education level (Hazard Ratio medium: 0.74 (0.63–0.87), high: 0.51 (0.43–0.62), very high: 0.39 (0.30–0.50) vs low). Results were similar for men. In PPMS, the risk was significantly different between the extreme groups (very high vs low) for women (0.45 (0.28–0.75)) and men (0.54 (0.32–0.91)), but no gradient was evident. Conclusion: Our study showed a strong association between education level and disability progression, regardless of sex and phenotype.

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Fichiers liés : Lefort - 2024 - Association between education level and disability progression in patients with multiple sclerosis in France _Manuscript_Education&Disability Leray MSJ pour HAL.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2025
• Auteurs : Olivier AsserinDanièle AyraultBenoît BaryAlberto BeccantiniPatrick BlaiseJ.-B. BlanchardFabienne BliardSophie Borel-SandouEmeric BourasseauJean-Christophe BrachetMatthieu BreuzéLaurent BriottetAli CharbalPierre-Étienne CharbonnelRaphael David-MenendezStanislas de LambertXavier DelauneThierry DelonOlivier FandeurVincent FaucherJean-Luc FayardCyril FeauEvelyne FoersterLaurent ForestPascal GalonClement GauchyFabrice GaudierClaire GauthierLionel GélébartDiogo GoncalvesStephane GounandCédric GourdinThomas HelferJérémy HureDenis HyvertClément IntroïniClémentine JacquemoudOlivier JamondLudovic JasonYann KayserSergey KudriakovRomain LagrangeThomas LaporteNicolas LelongAlain Le MaoultLe Pallec Jean-CharlesBertrand LeturcqValérie L'HostisStéphane LoubièrePaul MandinBernard MariniRenaud MassonBruno MichelSylvie NaurySéverine PaillardDomenico PanunzioSerge PascalCyril PatricotGregory PerezCécile PéteschEric PhilipPhilippe PiteauIoannis PolitopoulosBenoit PrabelMaria Adela PuscasIsabelle RamièreGilles RampalGiuseppe RastielloGuillaume RicciardiYannick RobertMaria Giovanna RodioGilles RodriguezDarius SeyediHélène SimonBenoit TanguyPierre VerpeauxLudovic Vincent
• Organismes : Service de Recherche en Matériaux et procédés Avancés Service de recherche en Corrosion et Comportement des Matériaux Service d'Etudes Mécaniques et Thermiques Service Physique EXpérimentale, d'essais en Sûreté et d'Instrumentation Service de Génie Logiciel pour la Simulation Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes de Simulation du Comportement du combustibles Service de Recherche en Matériaux et procédés Avancés Service d'Etudes Mécaniques et Thermiques Service de Physico-Chimie Service de Recherche en Matériaux et procédés Avancés Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service d'Etudes Mécaniques et Thermiques Département Technologie Nucléaire Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Département de Modélisation des Systèmes et Structures Service de Recherche en Matériaux et procédés Avancés Service d'Etudes Mécaniques et Thermiques Service de Génie Logiciel pour la Simulation Département Ingénierie Logiciels et Systèmes CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service de Recherche en Matériaux et procédés Avancés Commissariat à l'énergie atomique et aux énergies alternatives Service de Recherche en Matériaux et procédés Avancés Service d'Etudes Mécaniques et Thermiques Service d'Etudes de Simulation du Comportement du combustibles Service d'Etudes des Matériaux Irradiés Service d'Etudes Mécaniques et Thermiques Service d'Etudes de Simulation du Comportement du combustibles Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service d'Etudes Mécaniques et Thermiques Commissariat à l'énergie atomique et aux énergies alternatives Service d'Etudes Mécaniques et Thermiques CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service de Recherche en Matériaux et procédés Avancés Service d'Etudes de Simulation du Comportement du combustibles Service d'Etudes de Simulation du Comportement du combustibles Service d'Etudes Mécaniques et Thermiques Service de Thermo-hydraulique et de Mécanique des Fluides Service d'Etudes Mécaniques et Thermiques Service de Recherche en Matériaux et procédés Avancés Service d’Études des Réacteurs et de Mathématiques Appliquées Service de recherche en Corrosion et Comportement des Matériaux Service d'Etudes Mécaniques et Thermiques CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service de Thermo-hydraulique et de Mécanique des Fluides Service d'Etudes de Simulation du Comportement du combustibles Département de Modélisation des Systèmes et Structures Service d'Etudes Mécaniques et Thermiques Service de Technologie des Composants et des Procédés CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) Service de Génie Logiciel pour la Simulation Département Etude des Réacteurs Service d'Etudes Mécaniques et Thermiques Service d'Etudes Mécaniques et Thermiques Service d'Etudes des Matériaux Irradiés Service d'Etudes Mécaniques et Thermiques Service de Recherche en Matériaux et procédés Avancés

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Résumé : La mécanique, dans son aspect le plus primaire, est très probablement la plus ancienne des sciences de la nature, non pas car la plus simple mais parce qu’elle répond à des besoins existentiels de l’être humain : se loger, s’abriter, se protéger, se déplacer... en un mot : « bâtir ». Bien que la mécanique puise ses racines dans les savoirs anciens liés notamment aux réflexions d’Archimède ou Aristote, l’histoire de la mécanique moderne débute avec les travaux de Galilée. Les trois siècles qui lui ont succédé ont été fondamentaux pour la construction de la mécanique des structures telle que nous la pratiquons aujourd’hui. La mécanique des structures englobe des applications diverses, des physiques complexes et couplées. Si la mécanique des structures est une thématique scientifique transverse, les articles de cette monographie sont consacrés à son application dans le monde du nucléaire et tout particulièrement celui des réacteurs. Ce volume s’achève sur la valorisation des compétences acquises par la DES dans le cadre des réacteurs nucléaires, dans le domaine des nouvelles technologies de l’énergie en lien avec la mise en place de stratégies de décarbonation des usages domestiques et industriels.

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Fichiers liés : CEA_Mécanique_des_structures (1).pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2025
• Auteurs : Julien RouzotChristian ArtiguesPhilippe GarnierEmmanuel HebrardPierre LopezAdrien MaillardG Rabideau
• Organismes : Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Institut de recherche en astrophysique et planétologie Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Équipe Recherche Opérationnelle, Optimisation Combinatoire et Contraintes Jet Propulsion Laboratory Jet Propulsion Laboratory

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Résumé : In deep space missions, scientific data generated by onboard instruments must be temporarily stored in local memory buffers before being downlinked to Earth during limited communication windows. Efficient scheduling of these data transfers is essential to prevent buffer overflows and data loss, particularly in the presence of uncertainties. Previous work has considered the overlapping Memory Dumping Problem (oMDP), which consists in assigning transfer priorities to the memory buffers and minimize the peaks memory usage, which reduces the risk of overflow. In this paper, we consider additional decisions in the transfer plans that are implementable in practice: data transfer from each buffer can be interrupted after a given time, once per downlink window, preventing it from dumping data until the next window, but redistributing the unused bandwidth to the other buffers. The new problem is called oMDPi (oMDP with interruptions). We obtain new complexity results, showing that oMDPi is NP-complete for at least two windows. While the complexity status of the single window oMDPi remains open, we propose a polynomial-time heuristic to solve it. We propose a hybrid heuristic to solve the general oMDPi, embedding a flow relaxation and a single window heuristic. The results on both real and realistic generated instances show that our heuristic achieves a significant reduction of memory peaks in a reasonable time compared to previous works, making the new policy attractive for future space missions.

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Fichiers liés : OMDPI__HAL_.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2025
• Auteurs : Clara LocherNathalie ManaudMathieu MolimardCatherine Cassé-PerrotJean-Luc CracowskiCyril Di PalmaLuc DuchossoyChantal GatignolAnthony GoldgewichtOlivier HertelKarine LacombeCorentin LacroixPhilippe Moreau-ChevroletSylvie QueletPriscille RivièreMarie Claude Lagouanelle-SimeoniJoëlle Micallef
• Organismes : Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] CHU de Bordeaux Pellegrin [Bordeaux] Assistance Publique - Hôpitaux de Marseille Centre Régional de PharmacoVigilance [CHU Grenoble] MSD France Institut Pierre Louis d'Epidémiologie et de Santé Publique Sciences Po Agence Régionale de Santé Nouvelle-Aquitaine Institut National de la Santé et de la Recherche Médicale Assistance Publique - Hôpitaux de Marseille Assistance Publique - Hôpitaux de Marseille
• Publié dans Therapies le 04/10/2022

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Résumé : Recognising the pivotal role of health products in our society, the challenges around accessing reliable information in a fast-expanding digital environment, and the essential role played by health literacy in enabling citizens to make informed choices, this round table session was convened to identify strategies for improving health product education and understanding among the general public. Having discussed the concept of health literacy and those initiatives already in place, the participants put forward ten recommendations (R) for improving health product literacy: definition of a consensus-based common core of minimum knowledge about medicines to provide a benchmark level of public understanding (R1); development of a multimodal information campaign coordinated at national, local and individual levels (R2); implementation of long-term interventions with repeated, age-appropriate, and context-sensitive messaging (R3); early introduction of health product education early in schools via lessons and health services (R4); promotion of high-quality education by embracing psychosocial skills and co-constructing messages with public contributors (R5); proactive engagement in digital environments to ensure visibility of reliable content (R6); promotion and upscaling of existing initiatives and educational content (R7); introduction of a trusted structure that centralises validated content (R8); using prescriptions to deliver personalised information (R9); and contribution to national discussions around health-related misinformation (R10).

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Fichiers liés : Locher et al. - 2025 - How can the level of health product education (literacy) be raised among the general public.pdf

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