Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Michel HaïssaguerreJean-Marc SellalKarim BenaliBenjamin de BeckerPascal DefayePatrizio PascaleRaphaël P MartinsPhilippe MaboOlivier XhaetFabrice ExtramianaElodie SurgetThomas LavergneEloi MarijonPedro AdragaoMaria Salomé CarvalhoPaul-Ursmar MilliezMickael LaredoEstelle GandjbakhchCarla GiustettoFiorenzo GaitaRoland TilzLaurence Jesel-MorelJohannes SteinfurtThomas ArentzSebastien KnechtMattias DuytschaeverLaurent RotenTobias ReichlinMarjaneh FatemiJacques MansouratiClaude KouakamFrancis BessièrePhilippe ChevalierRafik TadrosLaurent MacleFrancisco GallegoAlexios HadjisFrederic SacherDylan PereiraJerome HourdainJean-Claude DeharoRomain EschalierGrégoire MassouliéPhilippe MauryDecebal Gabriel LatcuFrédéric AnselmeJosselin DuchateauRomain TixierKoonlawee NademaneeAkihiko NogamiNatasja de GrootEdward VigmondOlivier BernusMarc StrikPierre BordacharAude CathalaXavier BouteillerRemi DuboisSylvain Ploux
• Organismes : IHU-LIRYC CHU Pessac Service de Cardiologie [CHRU Nancy] CHU Pessac Université Jean Monnet - Saint-Étienne Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CHU UCL Namur AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hôpital Européen Georges Pompidou [APHP] Service de cardiologie et de pathologie vasculaire [CHU Caen] Institut de cardiologie [CHU Pitié-Salpêtrière] Università degli studi di Torino = University of Turin Service de cardiologie et de pathologie vasculaire [CHU Caen] Institut de cardiologie [CHU Pitié-Salpêtrière] Institut de cardiologie [CHU Pitié-Salpêtrière] Università degli studi di Torino = University of Turin University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein Hôpitaux Universitaires de Strasbourg Hôpitaux Universitaires de Strasbourg Médecine Cardiovasculaire Translationnelle University Heart Centre Freiburg - Bad Krozingen University Heart Centre Freiburg - Bad Krozingen Bern University Hospital [Berne] Bern University Hospital [Berne] Hôpital de la Cavale Blanche - CHRU Brest Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques Pole Cardio-vasculaire et pulmonaire [CHU Lille] Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] Montreal Heart Institute - Institut de Cardiologie de Montréal Montreal Heart Institute - Institut de Cardiologie de Montréal Montreal Heart Institute - Institut de Cardiologie de Montréal Hôpital du Sacré-Coeur de Montréal CHU Pessac CHU Trousseau [Tours] CHU Trousseau [Tours] Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] CHU Clermont-Ferrand CHU Clermont-Ferrand Service Cardiologie [CHU Toulouse] Centre Hospitalier Princesse Grace CHU Rouen IHU-LIRYC CHU Pessac CHU Pessac Bumrungrad International Hospital [ Bangkok] Erasmus University Medical Center [Rotterdam] IHU-LIRYC IHU-LIRYC IHU-LIRYC CHU Pessac IHU-LIRYC CHU Pessac CHU Pessac CHU Pessac IHU-LIRYC IHU-LIRYC CHU Pessac
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Marion CremoniMaxime TeisseyreOlivier ThaunatCéline FernandezChristine PayreAlan MoutouHadi ZarifVesna BrglezLaetitia AlbanoValérie MoalGeorges MouradEmmanuel MorelonBruno Hurault de LignyPhilippe ZaouiEric RondeauNacera OualiPierre RoncoBruno MoulinLaura Braun-ParvezAntoine DurrbachAnne-Elisabeth HengPhilippe GrimbertDidier DuclouxGilles BlanchoPierre MervilleGabriel ChoukrounYannick Le MeurCécile VigneauChristophe MariatLionel RostaingJean-François SubraJean-Luc TaupinG. LambeauVincent EsnaultAntoine SicardBarbara Seitz-Polsky
• Organismes : Université Côte d'Azur - Faculté de Médecine Unité de Recherche Clinique Côte d’Azur Centre Hospitalier Universitaire de Nice Département de Néphrologie - Hôpital Pasteur [Nice] Unité de Recherche Clinique Côte d’Azur Centre Hospitalier Universitaire de Nice Département de Néphrologie - Hôpital Pasteur [Nice] Hospices Civils de Lyon Centre International de Recherche en Infectiologie Cellules B normales et pathogéniques - Normal and pathogenic B cell responses [CIRI] Université Claude Bernard Lyon 1 Service de Transplantation, Néphrologie et Immunologie Clinique [Lyon] Département Maladies Infectieuses et Tropicales [CHRU Montpellier] Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Institut de pharmacologie moléculaire et cellulaire Hospices Civils de Lyon Institut de pharmacologie moléculaire et cellulaire Unité de Recherche Clinique Côte d’Azur Département de Néphrologie - Hôpital Pasteur [Nice] Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM] Microbes Evolution Phylogénie et Infections Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Hospices Civils de Lyon Centre Universitaire des Maladies Rénales [CHU Caen] Université de Caen Normandie - UFR Santé Centre Hospitalier Universitaire [CHU Grenoble] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Service de néphrologie et hémodialyse [CHU de Strasbourg] Centre Hospitalier Universitaire [Strasbourg] Immunologie intégrative des tumeurs et immunothérapie des cancers CHU Gabriel Montpied [Clermont-Ferrand] Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand] CHU Henri Mondor [Créteil] Centre Hospitalier Régional Universitaire de Besançon Service de Néphrologie [CHRU Besançon] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Néphrologie [Nantes] CHU de Bordeaux Pellegrin [Bordeaux] Service de Néphrologie-transplantation-dialyse [Bordeaux] Service de Néphrologie-Dialyse-Transplantation [CHU Amiens-Picardie] Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 CHRU Brest - Service de Nephrologie Lymphocytes B, Autoimmunité et Immunothérapies Service de néphrologie [Rennes] Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service de Néphrologie Dialyse, Transplantation rénale [CHU Saint Etienne] Département de Néphrologie et Transplantation d'organes [CHU Toulouse] Centre Hospitalier Universitaire d'Angers Hopital Saint-Louis [AP-HP] Institut de pharmacologie moléculaire et cellulaire Département de Néphrologie - Hôpital Pasteur [Nice] Centre Hospitalier Universitaire de Nice Département de Néphrologie - Hôpital Pasteur [Nice] Centre Hospitalier Universitaire de Nice Unité de Recherche Clinique Côte d’Azur Département de Néphrologie - Hôpital Pasteur [Nice]
• Publié dans Kidney International Reports le 26/10/2020

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Résumé : Introduction: Membranous nephropathy can lead to end-stage kidney disease, for which kidney transplantation is the preferred therapy. However, the disease often relapses, which can impact allograft survival. Methods: We conducted a prospective multicenter study in France involving 72 patients with membranous nephropathy who were awaiting and then underwent kidney transplantation. In addition, we established a retrospective validation cohort of 65 patients. The primary objective was to evaluate the prognostic significance of pretransplant anti phospholipase A2 receptor 1 (PLA2R1) antibodies on the recurrence of membranous nephropathy. The study also assessed the incidence rate, time to onset, and risk factors for recurrence, as well as allograft outcome. Results: The prospective cohort showed a 26% cumulative incidence of membranous nephropathy recurrence after a median follow-up of 23.5 months. This was confirmed by a 28% cumulative incidence after a median follow-up of 67 months in the retrospective cohort. A strong association was found between the presence of anti-PLA2R1 antibodies prior to transplantation and the risk of disease recurrence (risk ratio = 5.9; 95% confidence interval [CI]: 2.3-15.7; P < 0.0001). These results were confirmed in the retrospective cohort. Monitoring of anti-PLA2R1 antibodies in the immediate posttransplant period is of limited value, because recurrence occurred early in the first 6 months (median delay of 5 [3-14] months) after transplantation despite decreasing antibody levels. Conclusion: The presence of anti-PLA2R1 antibodies prior to transplantation was a strong predictor of recurrence of allograft membranous nephropathy. An individualized immunomonitoring and management strategy for kidney transplant candidates with anti-PLA2R1-associated membranous nephropathy should be considered.

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Fichiers liés : 1-s2.0-S2468024924019405-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Ambre LoiodiceSébastien Bailly PharmdStéphane RucklyNiccolò BuettiFrançois BarbierQuentin StaiqulyAlexis TabahJean-François TimsitAlexis TabahJeffrey LipmanAlexis TabahHamish PollockAndrew UdyMeredith YoungNeeraj BhadangeSteven TylerAnne LedtischkeMackenzie FinnisJyotsna DwivediManoj SaxenaVishwanath BiradarNatalie SoarVineet SarodeDavid BrewsterAdrian RegliElizabeth WeedaSamiul AhmedCheryl FourieKevin LauplandMahesh RamananJames WalshamJason MeyerEdward LittonAnna Maria PalermoTimothy YapEge ErogluAntony George AttokaranC'Havala JaramilloKhalid Mk NafeesKhalid Mahmood Khan NafeesNurhikmahtul Aqilah Haji Abd RashidHaji Adi Muhamad Ibnu WalidTomas MonP. Dhakshina MoorthiShah SudhirchandraDhadappa Damodar SridharanQiu HaiboJianfeng XieQiu HaiboXie JianfengLu Wei-HuaWang ZhenChuanyun QianJili LuoXiaomei ChenHao WangPeng ZhaoJuan ZhaoQiu WusiChen MingminLei XuChengfen YinRuilan WangJinfeng WangYongjie YinMin ZhangJilu YeChungfang HuSuming ZhouMin HuangJing YanYan WangBingyu QinLing YeXie WeifengLi PeijeNan GengLowell LingLowell LingYoshiro HayashiYoshiro HayashiToshiyuki KarumaiMasaki YamasakiSatoru HashimotoKoji HosokawaJun MakinoTakeo MatsuyoshiAkira KuriyamaHidenobu ShigemitsuYuka MishimaMichio NagashimaHideki YoshidaShigeki FujitaniKoichiro OmoriHiroshi RinkaHiroki SaitoKaori AtobeHideaki KatoShunsuke TakakiHelmi SulaimanM. Shahnaz HasanMuhamad Fadhil Hadi JamaluddinLee See PhengSheshendrasurian VisvalingamMun Thing LiewSiong Ling Danny WongKean Khang FongHamizah Bt Abdul RahmanZuraini Md NoorKok Tong LeeAbd. Hamid AzmanMohd Zulfakar MazlanSaedah AliAaron Mark HernandezAnton AbelloKyeongman JeonKyeongman JeonSang-Min LeeSunghoon ParkSeung Yong ParkSung Yoon LimAndrea Lay Hoon KwaQing Yuan GohQing Yuan GohShin Yi NgSui an LieAndrea Lay Hoon KwaKen Junyang GohAndrew Yunkai LiCaroline Yu Ming OngJia Yan LimJessica Lishan QuahKangqi NgLouis Xiang Long NgTony Yu-Chang YehYu Chang YehNai-Kuan ChouCong-Tat CiaTing-Yu HuLi-Kuo KuoShih-Chi KuPhunsup WongsurakiatPhunsup WongsurakiatYutthana ApichatbutrSupattra ChiewroongrojAdel AlsisiRashid NadeemAshraf El HoufiAdel AlsisiAdel AlsisiAmr ElhadidyMina BarsoumNermin OsmanTarek MostafaMohamed ElbahnasawyAhmed SaberAmer AldhaliaOmar ElmandouhAhmed ElsayedMerihan ElbadawyAhmed AwadHanan HemeadFarid ZandFarid ZandMaryam OuhadianSeyed Hamid BorsiZahra MehrabanDavood KashipazhaFatemeh AhmadiMohsen SavaieFarhad SoltaniMahboobeh RashidiReza BaghbanianFatemeh JavaherforooshFereshteh AmiriArash KianiMohammad Amin ZargarAta MahmoodpoorFatemeh AalinezhadGholamreza DabiriGolnar SabetianHakimeh SarshadMansoor MasjediRamin TajvidiAbdullah Khudhur AhmedPierre SingerPierre SingerIlya KaganMerav RiglerDaniel BelmanPhillip LevinBelal HararaAdei DiabFayez AbillamaFayez AbilamaRebecca IbrahimAya FaresMuhammed ElhadiAhmad BuimsaedahMarwa GamraAhmed AqeelahAlmajdoub Ali Mohammed AliAhmed Gaber Sadik HomaidanBushray AlmiqlashHala BilkhayrAhmad BouhuwaishAhmed Sa TaherEman AbdulwahedFathi AbousninaAisha Khaled HdadaRania JobranHayat Ben HasanRabab Shaban Ben HasanIssam SerghiniRachid SeddikiBrahim BoukattaNabil KanjaaDoumiri MouhssineMaazouzi Ahmed WajdiTarek DendaneAmine Ali ZeggwaghBrahim HousniOujidi YounesAbdelhamid HachimiA. GhannamZ. BelkhadirMustafa Abu JayyabAli AithssainMarcus LanceShaikh NissarHend SallamOmar ElrabiGhaleb AlmekhlafiMaher AwadAhmed AljabbaryMohammad Karam ChaabanNatalia Abu-SayfMohammad Al-JadaanLubna BakrMounir BouazizOlfa TurkiWalid SellamiGabriela VidalPablo CentenoNatalia MorvilloJosé Oscar AcevedoPatricia Mabel LopezRubén FernándezMatías SeguraMarta AparicioIrene AlonzoYanina NuccetelliPablo MontefioreMario AriasLuis Felipe ReyesLuis Felipe ReyesSilvio Ñamendys-SilvaSilvio Ñamendys-SilvaJuan Romero-GonzalezMariana HermosilloRoberto Alejandro CastilloJesús Nicolás Pantoja LealCandy Garcia AguilarMara Ocotlan Gonzalez HerreraMissael Vladimir Espinoza VillafuerteManuel Lomeli-TeranJose Dominguez-CheritAdrian Davalos-AlvarezSilvio Ñamendys-SilvaLuis Sánchez-HurtadoBrigitte Tejeda-HuezoOrlando Perez-NietoErnesto Deloya TomasLiesbet de BusJan de WaeleGuy FrancoisLiesbet de BusJan de WaeleIsabelle HollevoetWouter DenysMarc BourgeoisSofie F.M. VanderhaeghenJean-Baptiste MeslandPierre HeninLionel HaentjensPatrick BistonCindérella NoelNathalie LayosBenoît MissetNicolas de SchryverNicolas SerckXavier WitteboleElisabeth de WaeleGodelive OpdenackerPedja KovacevicPedja KovacevicBiljana ZlojutroFilipovic-Grcic InaAida CustovicIna Filipovic-GrcicRadovan RadonicAna Vujaklija BrajkovicJasminka PersecSanja SakanMario NikolicHrvoje LasicMarc LeoneJean-François TimsitEtienne RuppeStephane RucklyPhilippe MontraversMarc LeoneCharlotte ArbelotJean-François TimsitJuliette PatrierN. ZappelaP. MontraversThierry DulacJérémy CastaneraJohann AuchabieAnthony Le MeurA. MarchalotM. BeuzelinAlexandre MassriCharlotte GuesdonEtienne EscudierPhilippe MateuJérémy RosmanOlivier LeroySerge AlfandariAlexandru NicaBertrand SouweineElisabeth CoupezThibault DuburcqEric KipnisPerrine BortolottiMathieu Le SouhaitierJean-Paul MiraPierre GarconMatthieu DupreyMartial ThyraultRémi PauletFrançois PhilippartMarc TranCédric BruelEmmanuel WeissSylvie JannyArnaud FoucrierPierre-François PerrigaultFlora DjanikianFrançois BarbierMarc GainnierJérémy BourenneGuillaume LouisRoland SmonigLaurent ArgaudThomas BaudryArmand Mekonted DessapKeyvan RazaziPierre KalfonGaëtan BadreRomaric LarcherJean-Yves LefrantClaire RogerBenjamine SartonStein SilvaSophie DemeretLoïc Le GuennecShidasp SiamiChristelle AparicioGuillaume VoiriotMuriel FartoukhClaire Dahyot-FizelierNadia ImziKada KloucheHendrik BrachtHendrik BrachtSandra HoheisenFrank BloosDaniel Thomas-RueddelSirak PetrosBastian PasiekaSimon DublerKarsten SchmidtAntje GottschalkCarola WempePhilippe LepperCarlos MetzDmitriy VidermanDmitriy VidermanYerlan UmbetzhanovMiras MugazovYelena BazhykayevaZhannur KaligozhinBaurzhan BabashevYevgeniy MerenkovTalgat TemirovKostoula ArvanitiKostoula ArvanitiDimitrios SmyrniotisVasiliki PsallidaGeorgios FildisisVasiliki SoulountsiEvangelos KaimakamisCristina IasonidouSofia PapotiFoteini RentaMaria VasileiouVasiliki RomanouVasiliki KoutsoukouMariana Kristina MateiLeora MoldovanIlias KaraiskosHarry PaskalisKyriaki MarmanidouM. PapanikolaouC. KampolisMarina OikonomouEvangelos KogkopoulosCharikleia NikolaouAnastasios SakkalisMarinos ChatzisMaria GeorgopoulouAnna EfthymiouVasiliki ChantziaraAikaterini SakagianniEirini PapageorgiouFadi AliGeorges DimopoulosMariota Panagiota AlmiroudiPolychronis MalliotakisDiamantina MarouliVasiliki TheodorouIoannis RetselasVasilios KouroulasGeorgios PapathanakosMatteo BassettiDaniele GiacobbeGiorgia MontrucchioGabriele SalesGennaro de PascaleLuca Maria MontiniSimone CarelliJoel VargasValentina Di GravioDaniele Roberto GiacobbeAngelo GratarolaElisa PorcileMichele MirabellaIvan DarouiGiovanni LodiFrancesco ZuccaroMaria Grazia SchleveninPaolo PelosiDenise BattagliniAndrea CortegianiMariachiara IppolitoDavide BellinaAndrea Di GuardoLorella PelagalliMarco CovottaMonica RoccoSilvia FiorelliAntonella CotoiaAnna Chiara RizzoAdam MikstackiBarbara TamowiczIrmina Kaptur KomorowskaAnna SzczesniakJozef BojkoAnna KotkowskaPaulina Walczak-WieteskaDominika WasowskaTomasz NowakowskiHanna BrodaAssoc Mariusz PeichotaIwona Pietraszek-GrzywaczewskaIgnacio Martin-LoechesAlessandra BisantiJosé Artur PaivaPedro PóvoaNuno CartozeTiago PereiraNádia GuimarãesMadalena AlvesAna Josefina Pinheiro MarquesAna Rios PintoAndriy KrystopchukAna TeresaAntónio Manuel Pereira de FigueiredoIsabel BotelhoTiago DuarteVasco CostaRui Pedro CunhaElena MolinosSara LedoJoana QueiróDulce PascoalinhoCristina NunesJosé Pedro MouraÉnio PereiraAntónio Carvalho MendesLiana ValeanuLiana ValeanuSerban Bubenek-TurconiIoana Marina GrintescuCristian CobilinschiDaniela Carmen FilipescuCornelia Elena PredoiDana TomescuMihai PopescuAlexandra MarcuIoana GrigorasOlguta LunguAlexey GritsanAlexey GritsanAnastasia AnderzhanovaYulia MeleshkinaMarat MagomedovNadezhda ZubarevaMaksim TribulevDenis GaigolnikAleksandr EremenkoNatala VistovskayaMaria ChukinaVladislav BelskiyMikhail FurmanRicard Ferrer RoccaRicard Ferrer RoccaMaria MartinezVanessa CasaresRicard Mellado ArtigasPaula VeraMatias FloresJoaquin Amador AmerigoMaria Pilar Gracia ArnillasRosana Munoz BermudezFernando ArmestarBeatriz CatalanRegina RoigLaura RaguerMaría Dolores QuesadaEmilio Diaz SantosGemma GomàAlejandro UbedaMaria SalgadoLorena Forcelledo EspinaEmilio Garcia PrietoMj AsensioM. RodriguezDr Emilio MasedaAlejandro Suarez de la RicaJ. Ignacio AyestaranMariana NovoMiguel Angel Blasco-NavalpotroAlberto Orejas GallegoFredrik SjovallFredrik SjövallDzana SpahicCarl Johan SvenssonMichael HaneyAlicia EdinJoyce ÅkerlundLina de GeerJosef PrazakNiccolò BuettiJosef PrazakStephan JakobJl PaganiS. Abed-MaillardMurat AkovaAbdullah Tarık AslanMurat AkovaAbdullah Tarik AslanArif TimurogluSesin KocagozHulya KusogluSelcuk MehtapSolakoğlu CeyhunDr. Neriman Defne AltintasLeyla TalanBircan KayaaslanAyşe Kaya KalemDr. Ibrahim KurtMurat TelliBarcin OzturkÇiğdem ErolEmine Kubra Dindar DemiraySait ÇolakTürkay AkbasAli SariCanan AgalarOnur ÇolakMesut YilmazBurcu TunayRumeysa CakmakNese SaltogluRidvan KaraaliAhmet ErogluKemal Tolga SaracogluYeliz BilirSeda GuzeldagGulden ErsozGuliz EvikHulya SungurtekinCansu OzgenCem ErdoğanYunus GürbüzNilgün AltinYasar BayindirYasemin ErsoySenay GoksuAhmet AkyolKartal DrAyse BatirelSabahat Cagan AktasAndrew Conway MorrisAndrew Conway MorrisMatthew RoutledgeAndrew Conway MorrisAri ErcoleDavid AntcliffeRoceld RojoKate TizardMaria FaulknerAmanda CowtonMelanie KentAshok RajArtemis ZormpaGeorge TinaslanidisReena KhadeTomasz TorlinskiRandeep MulhiShraddha GoyalManan BajajMarina SoltanAimee YonanRachael DolanAimee JohnsonCaroline MacfieJames LennardMaie TempletonSonia Sousa AriasUwe FrankeKeith HugillHollie AngellKatherine CobbStephen ColeTim SmithClive GrahamJaroslav CermanAllison KeeganJenny RitzemaAmanda SandersonAshraf RoshdyTamas SzakmanyTom BaumerRebecca LongbottomDaniel HallKate TathamS. LoftusA. HusainE. BlackS. JhanjiR. Rao BaikadyPeter McguiganRachel MckeeSanthana KannanSupriya AntrolikarNicholas MarsdenValentina Della TorreDorota BanachAhmed ZakiMatthew JacksonMoses ChikungwaBen AttwoodJamie PatelSally HumphreysPaul Jean RenaudAnton SokhanYaroslava BurmaWendy SliglWendy SliglNadia BaigLorena MccoshenDemetrios KutsogiannisWendy SliglPatricia ThompsonTayne HewerRaihan RabbaniRaihan RabbaniShihan Mahmud Redwanul HuqRajib HasanMohammad Motiul IslamMohan GurjarMohan GurjarArvind BaroniaNikhil KothariAnkur SharmaSaurabh KarmakarPriya SharmaJanardan NimbolkarPratit SamdaniR. VaidyanathanNoor Ahmedi RubinaNikhilesh JainMadhumati PahujaRitu SinghSaurav ShekharNabeel Muzaffar SyedAhmad OzairSuhail Sarwar SiddiquiPayel BoseAvijatri DattaDarshana RathodMayur PatelRenuka MkK Baby SailajaCarol DsilvaJagadish ChandranPralay GhoshSudipta MukherjeeKaladhar SheshalaKrushna Chandra MisraOyebola AdekolaSaidu Yusuf YakubuEuphemia Mgbosoro UgwuIbironke DesaluGabriel AsiyanbiMotunrayo OladimejiOlusola IdowuFowotade AdeolaMervyn MerMervyn MerMelanie Mc CreeDr. Bashir El SanousiAli Adil Ali KararElfayadh SaidahmedHytham K.S. HamidRomaric LarcherKada Klouche
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Clinical Microbiology and Infection le 30/10/2020

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Fichiers liés : 2024 Loiodice et al., Effect of adequacy.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Nicolas RichardAriane LeroyerDelphine LeyClaire DupontValérie BertrandPauline WilsCorine Gower-RousseauDominique TurckNathalie GuillonHélène SarterGuillaume SavoyeMathurin FumeryAl Ghossaini NajibAl Hameedi RaiedAl Turk SariaAgoute EricAntoine MatthieuAntonietti MichelAouakli AmarArmengol-Debeir LauraAroichane IbrahimAssi FadiAuxenfants EricAzzouzi KassemBankovski DamyanBarbry BernardBardoux NicolasBaron PhilippeBaudet AgnèsBayart PaulineBazin BriceBebahani ArashBecqwort Jean-PierreBellati SaraBenet VincentBen Ali HoussemBenard CoralieBenguigui CorinneBen Soussan EmmanuelBental AbdeslamBernet JacquesBernou KarineBertot PaulineBertiaux-Vandaële NathalieBertrand ValérieBilloud EmilieBiron NathalieBismuth BenjaminBlanchard CyrilBlondel FabienneBlondin ValérieBobula MariusBohon PhilippeBoivin EléonoreBon Djemah VanessaBoniface EricBankovski DamyanBonnière PhilippeBoruchowicz ArnaudBoualit MédinaBouazza AhlemBouche BrunoBourgeaux ClaudeBourgeois-Fumery MorganeBourguet ArnaudBoutaleb HamzaBouthors AlexisBranche JulienBrazier FrankBridenne MarieBrihier HélèneBril LauraBrung-Lefebvre MaudBulois PhilippeBurgiere PierreButel JoëlCanva-Delcambre ValérieCardot FlorenceCarette SandrineCarpentier PierreCassar Jean-FrançoisCassagnou MichelCastex FrançoisCatala PascaleStéphane CattanCatteau SylvianeCaujolle BernardCharpentier CloéChavance-Thelu MartheCheny AgatheChoteau AntoireClergue Pierre-YvesCoevoet HuguesCohen GilCollet RégisColin MarieColombel Jean-FredericCoopman StéphanieCordiez LucieCorvisart JeanCortot AntoineCouttenier FrédéricCrombe ValérieDaoudi AbdelhakimDapvril VincentDavion ThierryDecoster SébastienAurélien DejaegerRichard DelcenserieDeleplanque MarineDelesalle DorothéeDelette OlivierDelgrange ThierryDelhoustal LaurenceDelmotte Jean-StéphaneDemmane SabriDeregnaucourt GuyDesechalliers Jean PierreDesmet PatrickDesreumaux PierreDesseaux GérardDesurmont PhilippeDevienne AlainDevouge EveDevroux AlexDewailly ArnaudDharancy SébastienDjamal DjeddiDjedir RachidDoleh WissamDreher-Duwat Marie LaureDuburque ClotildeDucrot FrédéricDucrotte PhilippeDufilho AndréDuhamel ChristianDumant-Forest CarolineJean-Louis DupasDupont FrédéricDuranton YvesDuriez ArnaudDuveau NicolasEl Achkar KhalilEl Farisi MohammadiElie CarolineDesmet PatrickElie-Legrand Marie-ClaireEoche MatthieuEssmaeel EssmaeelEvrard DominiqueEvrard Jean-PaulFatome ArmelleFinet LaurentFlahaut MathildeFlamme CamilleFoissey DavidFournier PeggyFoutrein-Comes Marie-ChristineFoutrein PhilippeFrere ThierryGaland JulieGallais PhilippeGamblin ClaudineGanga SergeGerard RomainGhrib SalahGilbert ThierryGodart DenisGodchaux Jean-MichelGoegebeur GuettyGoria OdileGottrand FredericLucien GradosGrandmaison BrigitteGroux MarionGuedon ClaireGuerbeau LoïcGueroult-Dero MathildeGuillem LaurenceGuillemot FrançoisGuimber DominiqueHaddouche BayaVincent HautefeuilleHecquet GenevièveHedde Jean-PierreHenneresse Pierre-EmmanuelHeyman BrunoHeraud MichelHerve SophieHochain PatrickHoussin-Bailly LucieHoucke PhilippeHuguenin BrunoIobagiu SilviuIstanboli ShataIvanovic AlexsandarIwanicki-Caron IsabelleJanicki EricJarry MarineJean Bart CharlotteJouvenet AnneKatherin FadiKerleveo AndréKhachfe AliKiriakos JeanKlein OlivierKohut MatthieuKornhauser RichardLaberenne Jean-EricLacotte EricLaffineur GuyLagarde MarineLahaye AnouckLalanne ArnaudLalieu AmbroiseLannoy PierreLaprand MichelLaude DenisLeblanc RachidaLecleire StéphaneLeclerc NathalieLe Couteulx ChristianLefilliatre PascaleLegrand CélineLemaitre CarolineJean-Philippe Le MouelLepeut GabrielLepileur LucieLepoutre-Dujardin ElodieLeroi HenriLeroy MaryvonneLe Roy PaulineLesage BenoitLesage XavierLesage JocelynLescanne-Darchis IsabelleLescut DominiqueLeurent BrunoLey DelphineLibier LouiseLoreau JulienLouvet AlexandreJoséphine LozinguezLubret HenriLucidarme DamienLugand Jean-JacquesMaetz DenisManolache OliviaMarks-Brunel Anne-BérangèreMarre CharlineMarzloff EricMathurin PhilippeMauillon JacquesMaunoury VincentMedam Djomo Michèle-AngeMelchior ChloéMelki ZiadMethari LoftiMeurisse FranckMichaud LaurentModaine PatriciaMonthe AngéliqueMorel LoïkMorin MathildeMortier Pierre EugeneMouterde OlivierMozziconaci NicolasMudry JeanNachury MariaNgo Minh DungEric Nguyen-KhacNotteghem BertrandOllevier VincentOuraghi AtikaOussadou BarrizaPainchart ClaireParent BrunoPatrier PhilippePaupard ThierryPauwels MathieuPetit RichardPiat MurielPiotte SandrinePlane ChristophePlouvier BernardPommelet PierrePop DanielaPordes CharlottePouchain GérardPrades PhilippePrevost Jean ChristopheQuartier GillesQueuniet Anne-MarieQuinton Jean-FrançoisRabache AlainRatajczyk SébastienReix NicoleRenaut-Vantroys ThibaudRevillion MarineRiachi GhassanClémentine RiaultRichard NicolasRichez CécileRimbert BenoitRodriguez Juan DanielRoux Jean-MarcRudelli AlainSaingier ClémenceSavoye GuillaumeSchlossberg PatrickSefrioui DavidSeguy DavidSeminur CelikSpyckerelle ClaireTalbodec NathalieTavernier NoémieTchandeu HenrietteTechy AuroreHenri ThiebaultThorel Jean-MarieThuillier ChristopheTielman GuillaumeTode ManuelaTouchais Jean-YvesToumelin PierreTouze YvanTran LéaTranvouez Jean-LucTriki NadiaTurck DominiqueJustine TurpinUhlen StéphanieVaillant EricValmage ClaudeVanco DominiqueVandaele-Bertiaux NathalieVandamme HélèneVanderbecq EtienneVander Eecken EliseVandermolen PhilipeVandevenne PhilippeVandeville LionelVandewalle AlainVanhoove Jean-PierreVanrenterghem AudreyVanveuren CharlotteVasies IonaVerbiese GuyVerlynde JulietteVernier-Massouille GwenolaVermelle PhilippeVerne ChristineVezilier-Cocq PerrineViart JulietteVigneron BenoitVincendet MarcWallez Jean-YvesWantiez MichelWartel FaustineWeber Jean-ChristianWillocquet Jean-LouisWizla NathalieWolschies EricZaharia OanaZaoui SoniaZalar AlbertoZellweger Anne
• Organismes : Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Biomécanique et Bioingénierie Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Institute for Translational Research in Inflammation - U 1286 Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Institute for Translational Research in Inflammation - U 1286 Service d'Hépato-Gastroentérologie [CHU Rouen] CHU Rouen CHU Amiens-Picardie CHU Amiens-Picardie CHU Amiens-Picardie Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV CHU Amiens-Picardie CHU Amiens-Picardie
• Publié dans Digestive and Liver Disease le 01/11/2020

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Résumé : Introduction: Patients with inflammatory bowel disease (IBD) are at higher risk of thromboembolic events (TE). In pediatric-onset IBD, more data on incidence and risk factors of venous (VTE) and arterial events (ATE) at the population level are needed to guide thromboprophylaxis. Methods: All patients aged ≤ 16 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) between 1988 and 2011 in the prospective EPIMAD population-based registry were followed until 2013. Every TE occurring during the follow-up period was included. Results: A total of 1,344 patients were included: 1,007 with CD and 337 with UC, and a median diagnosis age of 14.3 years. After a median follow-up of 8.3 years, 2 (0.15 %) ATE and 15 (1.1 %) VTE occurred at median age of 20.4 years. The global incidence rate of thromboembolic events was 1.32 per 1000 person-years. Periods of active disease (HR=8.4, p = 0.0002), the 3-month-period following surgery (HR=16.4, p = 0.0002) and hospitalization (HR=21.7, p < 0.0001) were found to be associated with an increased risk of VTE. A lower rate of VTE was found in patients treated with 5-aminosalicylates (HR=0.1, p = 0.002). Conclusion: The risk of TE was low in this population. VTE were strongly associated with active disease, surgery and hospitalization.

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Fichiers liés : PIIS1590865824010041.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Emmanuel CanetNoëlle BruleMorgane PereFanny FeuilletGilles BlanchoLaurent Martin-LefevreClaire GarandeauKarim AsehnouneBertrand RozecAgnès DuveauLaurent DubeMarc PierrotStanislas HumbertPatrice TirotJean-Marc BoyerFrançois LabadieRené RobertThierry BenardT KerforneAntoine ThierryOlivier LesieurJean-François VincentMathieu LesouhaitierRaphaëlle LarmetCécile VigneauAngélique GoeppPierre BoujuCharlotte QuentinPierre-Yves EgreteauOlivier HuetAnne RenaultYannick Le MeurJean-Christophe VenhardMatthias BuchlerMarie-Hélène VoellmyFabien HerveDavid SchnellAnne CourteDenis GlotzLucile AmroucheMarc HazzanNassim KamarValérie MoalJérémy BourenneMoglie Le QuintrecMoglie Le QuintrecEmmanuel MorelonToufik KamelPhilippe GrimbertAnne-Elisabeth HengPierre MervilleAude GarinChristian HiesseBrice FermierChristiane MoussonCharlotte Guyot-ColosioNicolas BouvierJean-Philippe RerolleAntoine DurrbachSarah J. DrouinSophie CaillardLuc FrimatSophie GirerdLaetitia AlbanoLionel RostaingDominique BertrandAlexandre HertigPierre-François WesteelFlorent MontiniEric DelpierreDidier DorezEric AlamartineCarole OuisseVéronique SébilleJean Reignier
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital methodS in Patients-centered outcomes and HEalth ResEarch Team 3 : Integrative transplantation, HLA, Immunology and genomics of kidney injury Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Team 6 : Impact of acute inflammation on host pathogen interactions and lung homeostasis Service d'anesthésie et réanimation chirurgicale [Nantes] Hôpital Guillaume-et-René-Laennec [Saint-Herblain] Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Université d'Angers Centre Hospitalier de Cholet Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier de Laval Centre hospitalier de Saint-Nazaire Laboratoire des Sciences de l'Environnement Marin (LEMAR) Unité Littoral Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Fédération Hospitalo-Universitaire « SUrvival oPtimization in ORgan Transplantation » Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique] Bibliothèque interuniversitaire de santé Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Etablissement Français du Sang Bretagne Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Institut de recherche en santé, environnement et travail CH Vannes Groupe Hospitalier Bretagne Sud CH de Saint-Malo [Broussais] CH Morlaix CHRU Brest - Département d'Anesthésie Réanimation Optimisation des régulations physiologiques Hôpital de la Cavale Blanche - CHRU Brest CHRU Brest - Service de Nephrologie Lymphocytes B, Autoimmunité et Immunothérapies CHU Trousseau [Tours] Service de néphrologie et immunologie clinique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Membrane Signalling and Inflammation in reperfusion Injuries Ecole Polytechnique de l'Université de Nantes Centre Hospitalier d'Angoulême Centre hospitalier Saint-Brieuc Paimpol Tréguier Immunologie humaine, physiopathologie & immunothérapie Hôpital Necker - Enfants Malades [AP-HP] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Centre Hospitalier Régional Universitaire [Montpellier] methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : Background - Expanded criteria donors help to increase graft availability, but provide organs with an increased risk of delayed graft function. We aimed to investigate whether donor hypothermia decreases the risk of delayed graft function compared with normothermia. Methods - We did this multicentre, randomised, controlled, parallel-arm trial at 53 intensive care units and transplant centres in France. We included expanded criteria donors in whom death was diagnosed based on neurological criteria, in compliance with French law, and the recipients of their kidney grafts. Eligible expanded criteria donors were older than 60 years or were aged 50-59 years and had at least two other risk factors (history of hypertension, creatinine >132 μmol/L, or cerebrovascular cause of death). Donors were randomly assigned to hypothermia (34-35°C) or normothermia (36·5-37·5°C). Machine perfusion was used routinely. Randomisation was done using a computer-generated, interactive, web-response system, in permuted blocks (block size six), stratified by centre. Outcome assessors were masked; investigator masking was not feasible. The primary outcome was the proportion of kidney recipients with delayed graft function, defined as renal replacement therapy within 7 days after transplantation, assessed in the modified intention-to-treat (mITT) population, which included all recipients who received at least one kidney from an expanded criteria donor, with the exception of those under guardianship. Secondary outcomes in expanded criteria donors were the number of organs recovered and transplanted, kidney function, body temperature, total volume of fluids administered, blood pressure and need for vasopressors and inotropes, and adverse events (cardiovascular events, metabolic disturbances, and coagulation disorders). Secondary outcomes in kidney recipients were duration of hospital stay, kidney graft function and vital status at day 7, day 28, 3 months, and 1 year after transplantation, and adverse events (infections, cardiovascular events, and surgical complications). Secondary outcomes were assessed in the mITT population. The trial was registered at ClinicalTrials.gov, NCT03098706. Findings - Between Nov 9, 2017, and March 3, 2021, 365 donors were randomly assigned, of whom 298 (151 [51%] male, 147 [49%] female) provided kidneys to 526 recipients (323 [61%] male, 203 [39%] female). 251 recipients in the hypothermia group and 275 recipients in the normothermia group were included in the analysis. Graft function was delayed in 40 (16%) of 251 recipients in the hypothermia group and 58 (21%) of 275 recipients in the normothermia group (odds ratio 0·71 [95% CI 0·44-1·13]; p=0·14; absolute difference -5·2% [95% CI 11·8-1·5]). Compared with donors in the normothermia group, donors in the hypothermia group had higher highest mean arterial pressure (115 mm Hg [SD 22] vs 108 mm Hg [20]; p=0·001). 1 year after transplantation, recipients in the hypothermia group had a lower mean creatinine concentration (152·4 μmol/L [SD 59·1] vs 169·7 μmol/L [51·4]; p=0·0351) and a higher mean creatinine clearance (42·3 mL/min/1·73 m [15·8] vs 40·5 mL/min/1·73 m [17·9]; p=0·0414) than those in the normothermia group. No significant differences between groups were identified for any other secondary outcomes. Interpretation - Hypothermia in expanded criteria donors whose organs were routinely stored using machine perfusion did not decrease the frequency of delayed kidney graft function. However, hypothermia was associated with a lower serum creatinine concentration and a higher creatinine clearance 1 year after transplantation. Funding - French Ministry of Health and French Intensive Care Society.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2024
• Auteurs : Matthieu LegrandJérémy FalconeBernard CholleyHélène CharbonneauAmélie DelaporteAdrien LemoineMatthias GarotAlexandre JoostenClaude MeistelmanDelphine Cheron-LeroyJean-Philippe RivesBruno PasteneAntoine DewitteStéphanie SigautMarc Danguy Des DesertsCyrille TrucMatthieu BoissonSigismond LasockiPhilippe CuvillonUgo SchiffSamir JaberMorgan Le GuenAnaïs CaillardStéphane BarEdmundo Pereira de Souza NetoVincent ColasFlorin DimacheThibaut GirardotElsa JozefowiczSimon ViquesnelFrancis BerthierEric VicautEtienne GayatSimon MonziolsMylene DefayeThibault CamusJean-Jacques RobinAlexandre OuattaraIoana FetitaOlivier Joannes-BoyauEline BonnardelRémi BouquerelAntoine StrzeleckiThibaut FayonChristophe PelletierBenjamin Le GaillardThibaut GirardotGéraud AmoussouMaalik El BouyousfiBruno GanasciaCalliope ButrulleSoizic GergaudPierre HabrialSolène PessiotEmmanuel SamsonCaroline WolffNevena StankovaFarida AouatiJuliette KavafyanVlad SuparschiDan LongroisJulie Le RoyBenoit RossignolOlivier HuetChristophe BoissonPierre Olivier BonninMohamed DhaouadiGhislaine GardesMikael PerinSophie BrunetYann GricourtMarc-Olivier FischerStéphane DebrocziLucie RetournayPierre StrubPatrice VivinRachel DupaysT KerforneGabriel VianetVirginie ManzanoEric NollPierre-Olivier LudesThiên-Nga Chamaraux-TranCédric CireneiDjihad HamrounBenoit LebasGrégoire Andrieu AndrieuVincent EtienneRaphaël CinottiNatacha SimonDenis FrascaHélène BeloeilAmandine Le GallPetyo TechevLudovic MeuretJérémie JoffreHervé DupontBeny CharbitArthur DavyDavid LoboJean-Michel DevysBenjamin SoriaClémentine CholetCyrus MotamedAnne WynieckiValérie BillardMigena DemiriClement MilletSamuel DegoulChristophe CanevetCéline MounierFlavie DesrumauxJulia MartinezClaire TexierBenoit VoisinGuillaume DubreuilJacques de MontblancClaire MengelleLaura RuscioEmmanuel FutierJulie FayonBenoit BaiettoMarie VignaudYoann MunierBertille PaquetteDiana SaptefratZakia MachroubJean-Sébastien AubertGeorges Abi AbdallahNicolas PolgeNajla DachraouiAnne GodierDiane ZlotnikHélène NougueDarless ClausseSabrina MaSherifatou Salami-AdjavonPatrick RossignolFrancis BerthierRomain BarthélémyGabriel VianetDamien LogeartPeggy ReinerKarine PautratAlex HongMarine CoroirClaire MayeurJacques ThesFlorent LaverdureSofiane SeriVioleta BercanCristian Radu IonescuCaroline Gonnet PintonMarc LeoneNathalie LesavreJeanne ChatelonMarion PoirierAdrien RivoryStéphanie RoulletSean CoeckelenberghLeila ToubalJoanna RamadanKarine Nouette-GaulainBruno RalecChloé ThillChristophe GiacardiEtienne MontelescautPhilippe AriesBenoît TavernierJulie BelletRomain DelassusHélène TribouillardDaniel VerzilliAlice MillotAudrey de JongMarie GeniezVirginie MarreMichaëla PenneYvan PouzeratteGuillaume RaoMaxime CoutrotAlice BletBenoit PlaudEmmanuel BastoMathilde PonsinMarie-Christine BecqMaïté ChaussardAristide NtaheFrançois DépretLucie GuillemetArnaud ValentLyse FloresJulien BureySarah FerayYoann ElmalehSophie DupeyratThomas BauryClémentine TaconetThomas RimmeleElodie MazockyMarie Luce ParrouffeCatherine JadaudStanislas AbrardPierre-Antoine TroncheArthur VialEmma AkaAnne-Sophie BellocqJean-François CarabalonaBlandine FayardJean Marie GuyaderLetitia HuriauxIngrid MillotAntoine LamblinMarine DutourMathilde Roukhomovsky-MorettiPascal MeuretNadir OmraniBarnabé RaymondClemence RoyFlorent SigwaltXavier MerindolMathieu DesmardLouis BourreauPierre-Antoine AllainCharlotte Dei SvaldiBrenton Alexander
• Organismes : University of California [San Francisco] University of California Hôpital Claude Huriez [Lille] Hôpital Européen Georges Pompidou [APHP] Clinique Pasteur [Toulouse] Hôpital Marie-Lannelongue CHU Tenon [AP-HP] Sorbonne Université Hôpital Claude Huriez [Lille] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier Régional Universitaire de Nancy Hopital Saint-Louis [AP-HP] Département d'anesthésie [Gustave Roussy] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle Hôpital Beaujon [AP-HP] Groupe d'Etude de la Thrombose de Bretagne Occidentale Hôpital d'Instruction des Armées Clermont Tonnerre Hôpital Edouard Herriot [CHU - HCL] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Faculté de Médecine - Clermont-Auvergne Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Foch [Suresnes] Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques CHU Amiens-Picardie Simplification des soins chez les patients complexes - UR UPJV 7518 Centre hospitalier de Montauban Hôpital Saint Philibert [Lomme] Centre Hospitalier Universitaire [Strasbourg] Centre hospitalier de Valence Hôpital Roger Salengro [Lille] Service d'anesthésie réanimation chirurgicale [Rennes] Centre d'Investigation Clinique de Besançon Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière] Marqueurs cardiovasculaires en situation de stress Hôpital d'Instruction des Armées Clermont Tonnerre Hôpital d'Instruction des Armées Clermont Tonnerre Hôpital d'Instruction des Armées Clermont Tonnerre Hopital d'instruction des armées Sainte-Anne [Toulon] Hôpital d'Instruction des Armées Clermont Tonnerre Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance: Before surgery, the best strategy for managing patients who are taking renin-angiotensin system inhibitors (RASIs) (angiotensin-converting enzyme inhibitors or angiotensin receptor blockers) is unknown. The lack of evidence leads to conflicting guidelines. Objective: To evaluate whether a continuation strategy vs a discontinuation strategy of RASIs before major noncardiac surgery results in decreased complications at 28 days after surgery. Design, Setting, and Participants: Randomized clinical trial that included patients who were being treated with a RASI for at least 3 months and were scheduled to undergo a major noncardiac surgery between January 2018 and April 2023 at 40 hospitals in France. Intervention: Patients were randomized to continue use of RASIs (n = 1107) until the day of surgery or to discontinue use of RASIs 48 hours prior to surgery (ie, they would take the last dose 3 days before surgery) (n = 1115). Main Outcomes and Measures: The primary outcome was a composite of all-cause mortality and major postoperative complications within 28 days after surgery. The key secondary outcomes were episodes of hypotension during surgery, acute kidney injury, postoperative organ failure, and length of stay in the hospital and intensive care unit during the 28 days after surgery. Results: Of the 2222 patients (mean age, 67 years [SD, 10 years]; 65% were male), 46% were being treated with angiotensin-converting enzyme inhibitors at baseline and 54% were being treated with angiotensin receptor blockers. The rate of all-cause mortality and major postoperative complications was 22% (245 of 1115 patients) in the RASI discontinuation group and 22% (247 of 1107 patients) in the RASI continuation group (risk ratio, 1.02 [95% CI, 0.87-1.19]; P = .85). Episodes of hypotension during surgery occurred in 41% of the patients in the RASI discontinuation group and in 54% of the patients in the RASI continuation group (risk ratio, 1.31 [95% CI, 1.19-1.44]). There were no other differences in the trial outcomes. Conclusions and Relevance: Among patients who underwent major noncardiac surgery, a continuation strategy of RASIs before surgery was not associated with a higher rate of postoperative complications than a discontinuation strategy. Trial Registration: ClinicalTrials.gov Identifier: NCT03374449

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Fichiers liés : 2024 Legrand et al., Continuation vs Discontinuation.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2024
• Auteurs : Julien PelletPierre GératEmilie PétéAntoine RelaveGuillaume MartinentJean-Philippe HeuzéMickaël Campo
• Organismes : Sport et Environnement Social
• Publié dans Revista iberoamericana de psicología del ejercicio y el deporte le 13/01/2025

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• Type de publi. : Article dans une revue
• Date de publi. : 29/08/2024
• Auteurs : Sarah BaillyVanessa MachaultSamuel BeneteauPhilippe PalanyCamille FritzellRomain GirodJean-Pierre LacauxPhilippe QuénelClaude Flamand
• Organismes : Unité d'Epidémiologie [Cayenne, Guyane française] Laboratoire d'aérologie Unité d'Epidémiologie [Cayenne, Guyane française] Direction Inter-Régionale des Antilles-Guyane Unité d'Epidémiologie [Cayenne, Guyane française] Entomologie médicale [Cayenne, Guyane française] Laboratoire d'aérologie Institut de recherche en santé, environnement et travail École des Hautes Études en Santé Publique Institut Pasteur de la Guyane Institut Pasteur du Cambodge Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases Unité d'Epidémiologie [Cayenne, Guyane française]
• Publié dans Pathogens le 26/10/2020

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Résumé : French Guiana lacks a dedicated model for developing an early warning system tailored to its entomological contexts. We employed a spatiotemporal modeling approach to predict the risk of larvae presence in local households in French Guiana. The model integrated field data on larvae, environmental data obtained from very high-spatial-resolution Pleiades imagery, and meteorological data collected from September 2011 to February 2013 in an urban area of French Guiana. The identified environmental and meteorological factors were used to generate dynamic maps with high spatial and temporal resolution. The study collected larval data from 261 different surveyed houses, with each house being surveyed between one and three times. Of the observations, 41% were positive for the presence of larvae. We modeled the larvae risk within a radius of 50 to 200 m around houses using six explanatory variables and extrapolated the findings to other urban municipalities during the 2020 dengue epidemic in French Guiana. This study highlights the potential of spatiotemporal modeling approaches to predict and monitor the evolution of vector-borne disease transmission risk, representing a major opportunity to monitor the evolution of vector risk and provide valuable information for public health authorities.

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Fichiers liés : pathogens-13-00738.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/08/2024
• Auteurs : Laure PonthierBénédicte FranckJulie AutmizguineMarc LabriffePhilippe OvetchkinePierre MarquetAnders AsbergJean-Baptiste Woillard
• Organismes : Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation CHU Limoges Centre d'Investigation Clinique [Rennes] CHU Sainte Justine [Montréal] Université de Montréal Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation CHU Limoges Université de Montréal Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation CHU Limoges University of Oslo Oslo University Hospital [Oslo] Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation CHU Limoges
• Publié dans Antimicrobial Agents and Chemotherapy le 26/10/2020

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Résumé : Intravenous ganciclovir and oral valganciclovir display significant variability in ganciclovir pharmacokinetics, particularly in children. Therapeutic drug monitoring currently relies on the area under the concentration-time (AUC). Machine-learning (ML) algorithms represent an interesting alternative to Maximum-a-Posteriori Bayesian-estimators for AUC estimation. The goal of our study was to develop and validate an ML-based limited sampling strategy (LSS) approach to determine ganciclovir AUC(0-24) after administration of either intravenous ganciclovir or oral valganciclovir in children. Pharmacokinetic parameters from four published population pharmacokinetic models, in addition to the World Health Organization growth curve for children, were used in the mrgsolve R package to simulate 10,800 pharmacokinetic profiles of children. Different ML algorithms were trained to predict AUC(0-24) based on different combinations of two or three samples. Performances were evaluated in a simulated test set and in an external data set of real patients. The best estimation performances in the test set were obtained with the Xgboost algorithm using a 2 and 6 hours post dose LSS for oral valganciclovir (relative mean prediction error [rMPE] = 0.4% and relative root mean square error [rRMSE] = 5.7%) and 0 and 2 hours post dose LSS for intravenous ganciclovir (rMPE = 0.9% and rRMSE = 12.4%). In the external data set, the performance based on these two sample LSS was acceptable: rMPE = 0.2% and rRMSE = 16.5% for valganciclovir and rMPE = -9.7% and rRMSE = 17.2% for intravenous ganciclovir. The Xgboost algorithm developed resulted in a clinically relevant individual estimation using only two blood samples. This will improve the implementation of AUC-targeted ganciclovir therapeutic drug monitoring in children.

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Fichiers liés : Ponthier et al-2024-Application of machine learning models to predict the ganciclovir and valganciclovir.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/08/2024
• Auteurs : Anne-Lise GoujonVincent ArdAntoine LaurentAurélien PierreSophie CorsonPhilippe GouézinPhilippe LelongVidal Sophie-JeanneErmias Yeshitla Sengi
• Organismes : Technologie et Ethnologie des Mondes Préhistoriques Centre Français des Études Ethiopiennes Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut de recherche en informatique de Toulouse Musée Fenaille Conseil départemental de la Vendée Centre de Recherche en Archéologie, Archéosciences, Histoire École Doctorale TESC Temps - Espaces - Sociétés - Cultures, ED 327

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