Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/08/2024
• Auteurs : Anne-Lise GoujonVincent ArdAntoine LaurentAurélien PierreSophie CorsonPhilippe GouézinPhilippe LelongVidal Sophie-JeanneErmias Yeshitla Sengi
• Organismes : Technologie et Ethnologie des Mondes Préhistoriques Centre Français des Études Ethiopiennes Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut de recherche en informatique de Toulouse Musée Fenaille Conseil départemental de la Vendée Centre de Recherche en Archéologie, Archéosciences, Histoire École Doctorale TESC Temps - Espaces - Sociétés - Cultures, ED 327

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/08/2024
• Auteurs : Pierre-Antoine BeauvaisDidier BinderFrançoise BostynJean-Philippe CollinElsa DefranouldVincent DelvignePaul FernandesAlix GibaudMikaël Guiavarc'HMarie ImbeauxCéline Bressy-LeandriFrançois-Xavier Le BourdonnecLudovic MevelAntoine PasqualiniStéphane RenaultAntonin TomassoChristophe TufféryErwan Vaissié
• Organismes : Technologie et Ethnologie des Mondes Préhistoriques University of Cape Town Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Université Paris 1 Panthéon-Sorbonne Centre de recherches en archéologie et patrimoine Trajectoires - UMR 8215 Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Technologie et Ethnologie des Mondes Préhistoriques Paléotime Technologie et Ethnologie des Mondes Préhistoriques Laboratoire méditerranéen de préhistoire Europe-Afrique Centre de Recherche en Archéologie, Archéosciences, Histoire Archéologie, Terre, Histoire, Sociétés [Dijon] Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Ministère de la Culture Archéosciences Bordeaux Technologie et Ethnologie des Mondes Préhistoriques Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Laboratoire méditerranéen de préhistoire Europe-Afrique Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Centre National de la Recherche Scientifique Université Côte d'Azur Technologie et Ethnologie des Mondes Préhistoriques Ministère de la Culture Archéologies et Sciences de l'Antiquité De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich

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Résumé : Started in 2019, the Research Group (GDR) “Silex” is a consortium of about fifty researchers from various institutions interested in the diagnosis and transfer of siliceous raw materials during Prehistory. The research is structured around three complementary axes: 1. questioning the reliability of different analysis methods (axis 1); 2. enriching the data corpus through the use of harmonized tools (axis 2); 3. reflecting on the archaeological implications induced by methodological transformations over the last 15 years (axis 3). A transversal axis concerns publication and communication strategies with the aim of making data as accessible as possible. For these works, it was necessary to harmonize the vocabulary, build data recording tools, and develop exchange and visualization platforms. Inventory files of about fifteen lithotheques and the results of surveys conducted by GDR members since 2019 are now directly shared online under a free license specific for France (Etalab 2.0) compatible with the CC-BY license. This publication is based on a server and a mapping application (ArcGisOnLine) and a data warehouse (Nakala). The whole system enables georeferenced and descriptive data and associated images at different scales to be shared. Today, the data chain from their production to their publication, is a structured process, which enables to answer to the questions and constraints of archaeologists. The whole system allows both the enhancement of old data and the implementation of new surveys and characterizations data. The handling of these tools is facilitated through initial training sessions organized annually and follow up by various GDR members in charge of data validation. As a true collaborative platform, the proposed tool allows for the pooling of work at each one’s place, in a spirit of data sharing and protection and in compliance with FAIR principles.

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• Type de publi. : Article dans une revue
• Date de publi. : 28/08/2024
• Auteurs : Pierre TuletJoel van BaelenPierre BosserJérôme BrioudeAurélie ColombPhilippe GoloubAndrea PazmiñoThierry PortafaixMichel RamonetKarine SellegriMelilotus ThyssenLéa GestNicolas MarquestautDominique MékièsJean-Marc MetzgerGilles AthierLuc BlarelMarc DelmotteGuillaume DesprairiesMérédith DournauxGaël DuboisValentin DuflotKevin LamyLionel GardesJean-François GuillemotValérie GrosJoanna KolasinskiMorgan LopezO. MagandErwan NouryManuel Nunes-PinharandaGuillaume PayenJoris PianezzeDavid PicardOlivier PicardSandrine PrunierFrançois Rigaud-LouiseMichaël SicardBenjamin Torres
• Organismes : Laboratoire d'aérologie Laboratoire de l'Atmosphère et des Cyclones École Nationale Supérieure de Techniques Avancées Bretagne Equipe Marine Mapping & Metrology Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance Laboratoire de l'Atmosphère et des Cyclones Laboratoire de Météorologie Physique Laboratoire d’Optique Atmosphérique - UMR 8518 STRATO - LATMOS Laboratoire de l'Atmosphère et des Cyclones Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Laboratoire de Météorologie Physique Institut méditerranéen d'océanologie Laboratoire de l'Atmosphère et des Cyclones Observatoire des Sciences de l'Univers de La Réunion Laboratoire de l'Atmosphère et des Cyclones Observatoire des Sciences de l'Univers de La Réunion Laboratoire d'aérologie Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Observatoire des Sciences de l'Univers de La Réunion Laboratoire d'aérologie Laboratoire d’Optique Atmosphérique - UMR 8518 Laboratoire de l'Atmosphère et des Cyclones Norwegian Institute for Air Research Observatoire des Sciences de l'Univers de La Réunion Laboratoire de l'Atmosphère et des Cyclones Terres Australes et Antarctiques Françaises Observatoire des Sciences de l'Univers de La Réunion Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Chimie Atmosphérique Expérimentale Ecologie marine tropicale dans les Océans Pacifique et Indien Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Observatoire des Sciences de l'Univers de La Réunion Observatoire des Sciences de l'Univers de La Réunion Laboratoire Atmosphères, Milieux, Observations Spatiales Observatoire des Sciences de l'Univers de La Réunion Laboratoire d'aérologie Laboratoire de Météorologie Physique Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones Laboratoire d’Optique Atmosphérique - UMR 8518
• Publié dans Earth System Science Data le 23/10/2020

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Résumé : This article is devoted to the presentation of the MAP-IO observation program. This program, launched in early 2021, has enabled the observation of nearly 700 d of measurements over the Indian and Southern Ocean with the equipment of 17 meteorological and oceanographic scientific instruments on board the ship Marion Dufresne. Several observational techniques have been developed to respond to the difficulties of observations on board the ship, in particular for passive remote sensing data, as well as for quasi-autonomous data acquisition and transfer. The first measurements made it possible to draw up unprecedented climatological data of the Southern Ocean regarding the size distribution and optical thickness of aerosols, the concentration of trace gases and greenhouse gases, UV, and integrated water vapor.

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Fichiers liés : 81-Tulet-et-al-essd-2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/08/2024
• Auteurs : Aurélien DinhMartin McnallyEmma D’anglejanChristel Mamona KiluJulie LourtetRosemary HoMatthew ScarboroughMaria DudarevaGerald JesuthasanCecile Ronde OustauStéphane KleinLaura Escolà-VergéDolores Rodriguez PardoPierre DelobelJaime Lora-TamayoMikel Mancheño-LosaMaria Luisa Sorlí RedóJosé María Barbero AllendeCédric ArvieuxDanguole VaznaisièneThomas BauerAnne-Laure RouxLatifa NoussairStéphane CorvecMarta Fernández-SampedroNicolò RossiAdrien LemaignenMauro José Costa SallesTaiana Cunha RibeiroJulien MazetMilène SassoJean-Philippe LavigneAlbert SottoEtienne CanouïÉric SennevillePauline ThillOlivier LortholaryFanny LanternierLaura MorataAlex SorianoGérard GiordanoCamille FourcadeBernhard J H FrankJochen G HofstaetterClara DuranEric Bonnet
• Organismes : Hôpital Raymond Poincaré [AP-HP] Oxford University Hospitals NHS Trust Hôpital Raymond Poincaré [AP-HP] Hôpital Raymond Poincaré [AP-HP] Groupe Hospitalier Paris Saint-Joseph Oxford University Hospitals NHS Trust Oxford University Hospitals NHS Trust Oxford University Hospitals NHS Trust Oxford University Hospitals NHS Trust Université de Strasbourg Université de Strasbourg Vall d'Hebron University Hospital [Barcelona] Vall d'Hebron University Hospital [Barcelona] Centre Hospitalier Universitaire de Toulouse Hospital Universitario 12 de Octubre [Madrid] Hospital Universitario 12 de Octubre [Madrid] Hospital Universitario Puerta del Mar [Cádiz, Spain] Universidad de Alcalá [Alcalá de Henares, España] = University of Alcalá [Alcalá de Henares, Spain] = Université d'Alcalá [Alcalá de Henares, Espagne] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Lithuanian University of health Sciences Hôpital Raymond Poincaré [AP-HP] Hôpital Raymond Poincaré [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Marqués de Valdecilla Research Institute - Instituto de Investigación Marqués de Valdecilla [Santander] Hôpital Bretonneau Faculdade de Ciências Médicas Santa Casa de São Paulo [Brazil] Faculdade de Ciências Médicas Santa Casa de São Paulo [Brazil] Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nîmes Hôpital Cochin [AP-HP] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Joseph Ducuing - Varsovie [Toulouse] Hôpital Joseph Ducuing - Varsovie [Toulouse] Wilhelminenspital Vienna = Wilhelminen Hospital Wilhelminenspital Vienna = Wilhelminen Hospital Hôpital Raymond Poincaré [AP-HP] Hôpital Joseph Ducuing - Varsovie [Toulouse]
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : Background: Prosthetic joint infection (PJI) caused by Candida spp is a severe complication of arthroplasty. We investigated the outcomes of Candida PJI. Methods: This was a retrospective observational multinational study including patients diagnosed with Candida-related PJI between 2010 and 2021. Treatment outcome was assessed at 2-year follow-up. Results: A total of 269 patients were analyzed. Median age was 73.0 (interquartile range [IQR], 64.0-79.0) years; 46.5% of patients were male and 10.8% were immunosuppressed. Main infection sites were hip (53.0%) and knee (43.1%), and 33.8% patients had fistulas. Surgical procedures included debridement, antibiotics, and implant retention (DAIR) (35.7%), 1-stage exchange (28.3%), and 2-stage exchange (29.0%). Candida spp identified were Candida albicans (55.8%), Candida parapsilosis (29.4%), Candida glabrata (7.8%), and Candida tropicalis (5.6%). Coinfection with bacteria was found in 51.3% of cases. The primary antifungal agents prescribed were azoles (75.8%) and echinocandins (30.9%), administered for a median of 92.0 (IQR, 54.5-181.3) days. Cure was observed in 156 of 269 (58.0%) cases. Treatment failure was associated with age >70 years (OR, 1.811 [95% confidence interval {CI}: 1.079-3.072]), and the use of DAIR (OR, 1.946 [95% CI: 1.157-3.285]). Candida parapsilosis infection was associated with better outcome (OR, 0.546 [95% CI: .305-.958]). Cure rates were significantly different between DAIR versus 1-stage exchange (46.9% vs 67.1%, P = .008) and DAIR versus 2-stage exchange (46.9% vs 69.2%, P = .003), but there was no difference comparing 1- to 2-stage exchanges (P = .777). Conclusions: Candida PJI prognosis seems poor, with high rate of failure, which does not appear to be linked to immunosuppression, use of azoles, or treatment duration.

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Fichiers liés : ciae395.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/08/2024
• Auteurs : Samuel ChalléatNicolas FarrugiaJérémy S.P. FroidevauxAmandine GascNicolas PajuscoCarlos R AbrahamsOrlando Acevedo‐charryLudmilla M S AguiarZachary R AhlinFranz AipleCécile H. AlbertIrene AlcocerAna Sofia AlvesFrancisco AmorimLudmila B AndradePedro M AraújoFernando AscensãoSerge AucoinElias BaderDiego BalbuenaLuc BarbaroEder BarbierEliana Barona CortésLuis Emilio BarrieJosé L BartheldHenry BatesAlice BaudouinRichard D BeasonChrista BeckmannAmy BeestonGvan BeláKristen M BellisarioSimon BelshawGuillermo Velo-AntónRaone Beltrão‐mendesEnrico BernardThierry BeschePeter A BiroCathie BoléatMathieu BossaertAlly BradleyPaulo BrancoWijnand BredewoldPhilip A BriggsSylvio Romério Briglia-FerreiraEmily BucknerIvana BudinskiAlbane BurensRachel T BuxtonAndrés CanaveroPaulo CardosoFarah Carrasco-RuedaPaula C CaycedoFrédéric CazabanLara R CerveiraAda CeuppensAlain ChalléatAngela Chappa LarreaAdrien CharbonneauMina CharnauxPooja ChoksiJan CibulkaJulián Clavijo-BustosZuania Colón-PiñeiroSofia CondeMaria João CostaAntónio CotãoClément CouturierMarina D A ScarpelliLuis P da SilvaTom DavisNathalie de LacosteSarah L DeansSerge DentinKrzysztof DeoniziakSarah R DodginIvo dos SantosTudor I DraganoiuBruno DroletMarina H L DuarteGonçalo DuarteChloé DubsetFrank DziockAlice EldridgeSimon EliseDavid R ElliottArthur EnguehardKarl EsztlDarren M EvansDaniel M FerreiraSonia a F FerreiraDiogo F FerreiraAna Margarida FerreiraPenelope C FialasLauren Foster-ShanerBárbara FreitasNicholas R FriedmanSusan FullerDidier GalopDaniel GarsideJean-Christophe GattusSylvain GeoffrayLouis GodartLaurent GodetInês Gomes MarquesFernando González-GarcaPaul GriesbergerBilal HabibMadeline E HalletMeena M HaribalJennifer HatlaufSylvain HaupertJosé M HerreraSierra E HerzbergerFrederico Hintze OliveiraKathy H HodderIsabelle HoecherlMark F HulmeEmilia HylandMichel JacobsAkash JaiswalLaurent JégouSteve JonesHervé JourdanTomáš JůnekLeili KhalatbariSarika KhanwilkarJames J N KitsonAmanda H KorstjensKim Krähenbühl-KünzliNatalija LaceSébastien LaguetHedwig LankauThiago O LaranjeirasGregoire LauvinSamuel LavinMatthieu Le CorreMonica LeónJudah J LevensonPavel LinhartJuliette LinossierDiego J LizcanoDiego LlusiaMarty LockettPedro B LopesRicardo Jorge LopesJosé Vicente López-BaoAdrià López‐baucellsDavid López-BoschRicardo B MachadoClaude MandeGuillaume MarchaisFabio MarcolinOscar H Marn GómezCarina B MarquesJ. Tiago MarquesTilla MartinVanessa MataEloisa Matheu-CortadaVincent MédocKirsten E MillerBasile MontagneAllen MooreJomari M A MorenoFelipe N Moreno-GómezSandra MüllerDaniela Murillo-BedoyaLuciano N NakaAdrian C NewtonJoão T NunesPierrette NyssenFionn Ó MarcaighDarren P O’connellM. Teague O’maraDavid OcampoMeryem OuertaniJan Olav OwrenVitor H PaivaStéphane ParisMarion ParisotSwaroop PatankarJorge M PereiraSlvia Pereira BarreiroCédric PeyronnetMagalie PhillippeBryan C PijanowskiNuno PintoZach PoffJonathan M PoppeleAndrew PowerVictoria PrattDarren S ProppeRaphaël ProulxLaura PrughSebastien J PuechmailleXavier Puig-MontserratLorenzo QuagliettaJohn E QuinnNancy I QuirogaMariana RamosRebecca RasmussenGeorges ReckingerMimi ReedJean-Benoît ReginsterVanesa RiveraClara F RodriguesPatricia Mara Rodrguez-GonzálezEduardo Rodrguez-RodrguezLuke RomaineAndrei L RoosJoao RosaNull- J RossQuentin RouyAlyssa M RyserSougata SadhukhanRobin SandfortJosé Maria SantosDavid SavageStéphanie C Schai-BraunMichael Scherer-LorenzenMathilde Schoenauer SebagPedro SeguradoAna M SerronhaTaylor ShawBrenda ShepherdCárol Sierra-DuránBruno M SilvaVictoire SimonPeter F SinclairCarolina Soto-NavarroAnne SourdrilJérôme SueurLarissa S M SugaiIan B TarrantFran TattersallChristopher N TempletonMichelle E ThompsonMarcela ToddJuan D Tovar-GarcaKarina TownsendAmaro TuninettiPaul A UllrichJuan S Vargas SotoKevin VegaGabriella VentricePierre J VictorJosep Vidal OliverasSara Villén-PérezOlivier VinetAgnés VivatJean-Do VrignaultWilliam D J WaltonChristopher J WatsonOliver R WearnDamion L WhyteFredric M WindsorYanchen WuSelena XieIgnacio Zeballos PuccherelliVera Zina
• Organismes : Géographie de l'environnement Observatoire de l'environnement nocturne Institut Ecologie et Environnement - CNRS Ecologie et Environnement Institut des Sciences Humaines et Sociales - CNRS Sciences humaines et sociales Equipe Better Representations for Artificial Intelligence Département Mathematical and Electrical Engineering Centre de Recherches sur les Ecosystèmes d'Altitude Muséum national d'Histoire naturelle Institut méditerranéen de biodiversité et d'écologie marine et continentale Oregon State University Laboratoire d'Acoustique de l'Université du Mans Laboratoire d'Acoustique de l'Université du Mans Florida Museum of Natural History [Gainesville] University of Braslia, Braslia University of Washington [Seattle] Department of Epigenetics [Freiburg Im Breisgau] Institut méditerranéen de biodiversité et d'écologie marine et continentale Universidad Autónoma de Madrid Centre de Recherche en Paléontologie - Paris Centro de Investigação em Biodiversidade e Recursos Genéticos [Vairao] Universidade de Brasilia = University of Brasilia [Brasília] Institute of Marine Research [Bergen] Centre for Ecology - Evolution and Environmental Changes IDL-Faculdade de Ciencias da Universidade de Lisboa Parks Canada Agency Wildlife Consulting Dynamiques et écologie des paysages agriforestiers Universidade Federal de Pernambuco [Recife] Ligue pour la Protection des Oiseaux Hawkesbury Institute for the Environment [Richmond] Deakin University [Melbourne Burwood] Western Sydney University Géographie de l'environnement Géographie de l'environnement Littoral, Environnement, Télédétection, Géomatique Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires Université Toulouse - Jean Jaurès Géographie de l'environnement
• Publié dans Scientific Data le 29/10/2020

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Résumé : Political responses to the COVID-19 pandemic led to changes in city soundscapes around the globe. From March to October 2020, a consortium of 261 contributors from 35 countries brought together by the Silent Cities project built a unique soundscape recordings collection to report on local acoustic changes in urban areas. We present this collection here, along with metadata including observational descriptions of the local areas from the contributors, open-source environmental data, open-source confinement levels and calculation of acoustic descriptors. We performed a technical validation of the dataset using statistical models run on a subset of manually annotated soundscapes. Results confirmed the large-scale usability of ecoacoustic indices and automatic sound event recognition in the Silent Cities soundscape collection. We expect this dataset to be useful for research in the multidisciplinary field of environmental sciences.

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Fichiers liés : s41597-024-03611-7.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/08/2024
• Auteurs : Brice MarcPhilippe FoucherFlorence ForbesPierre Charbonnier
• Organismes : Evaluation non destructive des structures et des matériaux Modèles statistiques bayésiens et des valeurs extrêmes pour données structurées et de grande dimension Evaluation non destructive des structures et des matériaux Modèles statistiques bayésiens et des valeurs extrêmes pour données structurées et de grande dimension Evaluation non destructive des structures et des matériaux

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Résumé : Automatic anomaly detection on engineering structures is often carried out using supervised models, raising the issue of anomalous images acquisition and annotation. Unsupervised methods like normalizing flows achieve excellent results while trained with defect-free images only. However, normalizing flows methods, such as MSFlow, are generally applied on features extracted by an encoder pre-trained on datasets that may not be related to engineering structures images. Therefore, we investigate the possibility to derive more discriminative features with an additional fine-tuning of the feature extractor on images with synthetic anomalies. We consider two types of such anomalies and demonstrate their efficiency with MSFlow on the MVTec (Wood/Tile) and Crack500 datasets, with significantly improved predictions. Interestingly, both tasks produce similar results suggesting that pre-training is mainly improved by the healthy part of images and not very sensitive to anomaly realism. Additionally, when comparing our fine-tuned MSFlow with a reference supervised model, CT-CrackSeg, on the Crack500 dataset, we observe similar qualitative behaviours. This open a promising direction towards annotation-free, more scalable alternatives, in particular for anomaly detection in engineering structure applications.

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Fichiers liés : EUSIPCO (1).pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/08/2024
• Auteurs : Vilma DembitzHannah LawsonRichard BurtSirisha NataniCéline PhilippeSophie C JamesSamantha AtkinsonJozef DurkoLydia M WangJoana CamposAoife M S MageeKeith WoodleyMichael J AustinAna Rio-MachinPedro CasadoFindlay Bewicke-CopleyGiovanny Rodriguez BlancoDiego Pereira-MartinsLieve OudejansEmeline BoetAlex Von KriegsheimJuerg SchwallerAndrew FinchBela PatelJean-Emmanuel SarryJérôme TamburiniJan Jacob SchuringaLori HazlehurstJohn A Copland IiiMariia YunevaBarrie PeckPedro R CutillasJude FitzgibbonKevin Rouault-PierreKamil KrancPaolo Gallipoli
• Organismes : Barts Cancer Institute Queen Mary University of London University of Zagreb Queen Mary University of London The institute of cancer research [London] The Francis Crick Institute [London] Imperial College London Queen Mary University of London Barts Cancer Institute Queen Mary University of London Oncogenesis, Stress, Signaling Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Imperial College London The Francis Crick Institute [London] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The institute of cancer research [London] Queen Mary University of London Barts Cancer Institute The institute of cancer research [London] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Universidad Autónoma de Madrid Queen Mary University of London Barts Cancer Institute Instituto de Investigación Sanitaria Fundación Jiménez Diaz [Madrid] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The University of Edinburgh University Medical Center Groningen [Groningen] University of Groningen [Groningen] University Medical Center Groningen [Groningen] University of Groningen [Groningen] Centre de Recherches en Cancérologie de Toulouse Communauté d'universités et établissements de Toulouse The University of Edinburgh Université de Bâle = University of Basel = Basel Universität Queen Mary University of London Barts Cancer Institute Queen Mary University of London Centre de Recherches en Cancérologie de Toulouse Communauté d'universités et établissements de Toulouse Université de Genève = University of Geneva Swiss Institute for Experimental Cancer Research - Lausanne University Medical Center Groningen [Groningen] University of Groningen [Groningen] Mayo Clinic [Jacksonville] The Francis Crick Institute [London] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The institute of cancer research [London] Queen Mary University of London Barts Cancer Institute
• Publié dans Leukemia le 25/10/2020

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Résumé : Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) patients’ outcomes. We identify stearoyl-CoA desaturase (SCD), the key enzyme in fatty acid (FA) desaturation, as prognostic of patients’ outcomes and, using the clinical-grade inhibitor SSI-4, show that SCD inhibition (SCDi) is a therapeutic vulnerability across multiple AML models in vitro and in vivo. Multiomic analysis demonstrates that SCDi causes lipotoxicity, which induces AML cell death via pleiotropic effects. Sensitivity to SCDi correlates with AML dependency on FA desaturation regardless of mutational profile and is modulated by FA biosynthesis activity. Finally, we show that lipotoxicity increases chemotherapy-induced DNA damage and standard chemotherapy further sensitizes AML cells to SCDi. Our work supports developing FA desaturase inhibitors in AML while stressing the importance of identifying predictive biomarkers of response and biologically validated combination therapies to realize their full therapeutic potential.

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Fichiers liés : s41375-024-02390-9.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/08/2024
• Auteurs : Amélie CrépetPhilippe QuénelMadeline CarsiqueJeanne GarricPascal SandersJean-Marc BonmatinP DuchéAlain KaufmannJulien JeanJean-Pierre CravediMatthieu SchulerRobert Barouki
• Organismes : Direction de l'Evaluation des Risques Institut de recherche en santé, environnement et travail Direction de l'Evaluation des Risques Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Direction des affaires européennes et internationales Centre de biophysique moléculaire Université de Toulon Jeunesse - Activité Physique et Sportive, Santé Université de Lausanne = University of Lausanne Direction de l'Evaluation des Risques Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Institut National de la Santé et de la Recherche Médicale

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Résumé : BACKGROUND AND AIM: The exposome encompasses all environmental factors encountered over the life-course to explain their role in the development of health effects, in complement of the genome. Since the emergence of the concept in 2005, the scientific community has made a lot of efforts to produce new knowledge, data, methods and tools to assess the exposome and its impact on human health. However, the exposome has not yet been widely implemented by health and safety agencies and today, one of the key challenges is to include exposome-inspired approaches in health risk assessment. METHOD: After presenting the main recommendations to integrate the exposome in the risk assessment process, we will focus on chemical mixtures to practically show how the exposome can support risk assessment methodologies. RESULTS: Several applications of the different exposure and health data derived from studies in the French population will be presented: dietary exposure to chemical mixtures in children and women, exposure to pesticide mixtures from multiple sources of the general population and from occupational activity for agricultural workers, analysis of chemical mixtures from human biomonitoring data. CONCLUSIONS: The integration of approaches and knowledge relating to the exposome will enable environmental epidemiology and risk assessment to cross a decisive threshold, taking into account the contributions of citizen and participatory science wherever possible and useful. Developing the eco-exposome will also help for a better integration of human, animals and environmental health.

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• Type de publi. :
• Date de publi. : 25/08/2024
• Auteurs : Julie BorgMohamed-Mahmoud MemmahJean-Noël AubertotPhilippe BlancStéphanie DruschPascal BorioliDanièle BevacquaValérie GalliaBertrand GauffreHélène GautierMichel GénardIsabelle GrechiPierre P. FranckBaptiste LabeyrieClaire LavigneFrançoise LescourretVincent MercierChristophe MouirenDidace Ndalla LandouFrédéric NormandMarie-Hélène RobinAntoine RollandJulien RuescheNatacha SautereauPierre ValsesiaG. Vercambre
• Organismes : Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Génétique et Amélioration des Fruits et Légumes AGroécologie, Innovations, teRritoires Unité Expérimentale de Recherches Intégrées en Production Fruitière Groupement Régional CETA de Basse Durance Plantes et systèmes de culture horticoles Station de Recherche Appliquée Fruits et Légumes Centre d'Études Biologiques de Chizé - UMR 7372 Plantes et systèmes de culture horticoles Plantes et systèmes de culture horticoles Plantes et systèmes de culture horticoles Plantes et systèmes de culture horticoles Station d’Expérimentation Fruits Rhône-Alpes Plantes et systèmes de culture horticoles Plantes et systèmes de culture horticoles Unité Expérimentale de Recherches Intégrées en Production Fruitière Groupement Régional des Centres d'Etudes Techniques Agricoles de Basse Durance Fonctionnement agroécologique et performances des systèmes de cultures horticoles Ecole d'Ingénieurs de Purpan AGroécologie, Innovations, teRritoires Entrepôts, Représentation et Ingénierie des Connaissances Génétique Physiologie et Systèmes d'Elevage Institut Technique de l'Agriculture Biologique Plantes et systèmes de culture horticoles Plantes et systèmes de culture horticoles

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• Type de publi. : Article dans une revue
• Date de publi. : 22/08/2024
• Auteurs : Vincent Jean-PierrePauline SorlinKaty JeannotRaphaël ChironJean-Philippe LavigneAlix PantelH. Marchandin
• Organismes : Hydrosciences Montpellier Centre Hospitalier Universitaire de Nîmes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre National de Référence de la Résistance aux Antibiotiques Hydrosciences Montpellier Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques Centre Hospitalier Universitaire de Nîmes Hydrosciences Montpellier Centre Hospitalier Universitaire de Nîmes
• Publié dans Annals of Clinical Microbiology and Antimicrobials le 30/10/2020

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Résumé : Background : Cefiderocol is a siderophore-conjugated cephalosporin increasingly used in the management of Achromobacter infections. Testing for cefiderocol susceptibility is challenging with distinct recommendations depending on the pathogens. Objectives : We evaluated the performance of commercial tests for testing cefiderocol susceptibility in the Achromobacter genus and reviewed the literature. Methods : Diffusion (disks, MIC gradient test strips [MTS], Liofilchem) and broth microdilution (BMD) methods (ComASP™, Liofilchem; UMIC®, Bruker) were compared with the BMD reference method according to the EUCAST guidelines on 143 Achromobacter strains from 14 species with MIC50/90 of ≤ 0.015/0.5 mg/L. A literature search was conducted regardless of method or species. Results : None of the methods tested fulfilled an acceptable essential agreement (EA). MTS displayed the lowest EA (30.8%) after UMIC® (49%) and ComASP™ (76.9%). All methods achieved an acceptable bias, with MICs either underestimated using MTS (-1.3%) and ComASP™ (-14.2%) or overestimated with UMIC® (+ 9.1%). Inhibition zone diameters ranged from 6 to 38 mm (IZD50/90=33/30 mm). UMIC® and ComASP™ failed to categorize one or the two cefiderocol-resistant strains of this study as resistant unlike the diffusion-based methods. The literature review highlighted distinct performance of the available methods according to pathogens and testing conditions. Conclusions : The use of MTS is discouraged for Achromobacter spp. Disk diffusion can be used to screen for susceptible strains by setting a threshold diameter of 30 mm. UMIC® and ComASP™ should not be used as the sole method but have to be systematically associated with disk diffusion to detect the yet rarely described cefiderocol-resistant Achromobacter sp. strains.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12941-024-00731-1.

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Fichiers liés : s12941-024-00731-1.pdf

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