Philippe JEAN-PIERRE

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• Type de publi. : Autre publication
• Date de publi. : 01/08/2024
• Auteurs : Ewen MullinsJean‐louis BressonTamas DalmayIan Crawford DewhurstMichelle EpsteinLeslie George FirbankPhilippe GuercheJan HejatkoHanspeter NaegeliFrancisco Javier MorenoFabien NoguéNils RostoksJose Juan Sánchez SerranoGiovanni SavoiniEve VeromannFabio VeronesiMichele ArdizzoneGiacomo de SanctisAntonio Fernandez DumontAndrea GennaroJosé Ángel Gómez RuizPaschalina GrammatikouTilemachos GoumperisPaolo LenziAleksandra LewandowskaAna Martin CamargoFranco Maria NeriPietro PiffanelliTommaso RaffaelloKyriaki Xiftou
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans EFSA Journal le 01/11/2020

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Résumé : Abstract Genetically modified (GM) maize DP910521 was developed to confer resistance against certain lepidopteran insect pests as well as tolerance to glufosinate herbicide; these properties were achieved by introducing the mo‐pat, pmi and cry1B.34 expression cassettes. The molecular characterisation data and bioinformatic analyses did not identify issues requiring food/feed safety assessment. None of the identified differences in the agronomic/phenotypic and compositional characteristics tested between maize DP910521 and its conventional counterpart needs further assessment except for the levels of iron in grain, which do not raise safety and nutritional concerns. The GMO Panel does not identify safety concerns regarding the toxicity and allergenicity of the Cry1B.34, PAT and PMI proteins as expressed in maize DP910521. The GMO panel finds no evidence that the genetic modification impacts the overall safety of maize DP910521. In the context of this application, the consumption of food and feed from maize DP910521 does not represent a nutritional concern in humans and animals. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and non‐GM maize varieties tested, and no post‐market monitoring of food/feed is considered necessary. In the case of accidental release of maize DP910521 material into the environment, this would not raise environmental safety concerns. The post‐market environmental monitoring plan and reporting intervals are in line with the intended uses of maize DP910521. The GMO Panel concludes that maize DP910521 is as safe as its conventional counterpart and the tested non‐GM maize varieties with respect to potential effects on human and animal health and the environment.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/07/2024
• Auteurs : Anne-Magali Seydoux-GuillaumePierre-Marie ZanettaPierre RochetteE. GardesPhilippe de ParsevalB.P. Glass
• Organismes : Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Laboratoire Magmas et Volcans Géosciences Environnement Toulouse University of Delaware [Newark]

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2024
• Auteurs : Lou GrangeonGrégoire BoulouisJean CapronFouzi BalaDimitri RenardNicolas RaposoOzlem Ozkul-WermesterAude Triquenot-BaganXavier AyrignacDavid WallonEmmanuel GerardinPhilippe KerschenDenis SablotMaïté FormaglioFernando PicoGuillaume TurcMarc VernyLisa HumbertjeanMarie GaudronStéphane VannierNelly DequatreBenoit GuillonClothilde IsabelCaroline ArquizanOlivier DetanteSophie GodardBarbara CasollaMichael LevrautCédric GollionMathieu Gerfaud-ValentinLaurent KremerLaure DaelmanNicolas LambertSylvain LanthierAlexandre PoppeAlexis RégentDavid Weisenburger-LilePierre VerdureGérald QuesneyMathieu VautierAnne WacongneEric ThouvenotJérémie ParienteSarah CoulettePierre M. LabaugeNadège OlivierThibaut AllouHelene ZephirAntoine NéelSaskia BreschBenjamin TerrierOlivier MartinaudRomain SchneckenburgerThomas PapoChloé Comarmond-OrtoliEric JouventMarie SubrévilleLouis Poncet-MegemontMuhammad A. KhatibFrançois LunCarole HenryEloi MagninQuentin ThomasMathilde GraberYassine BoukricheGeneviève Blanchet-FourcadeDiana RatiuChristian PagnouxEmmanuel TouzéHubert de BoyssonSonia AlamowitchAhmad Nehme
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Neurology le 01/11/2020

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Résumé : Background and Objectives Cerebral amyloid angiopathy-related inflammation (CAA-RI) and biopsy-positive primary angiitis of the CNS (BP-PACNS) have overlapping clinicoradiologic presentations. It is unknown whether clinical and radiologic features can differentiate CAA-RI from BP-PACNS and whether both diseases have different relapse rates. The objectives of this study were to compare clinicoradiologic presentations and relapse rates in patients with CAA-RI vs BP-PACNS. Methods Patients with CAA-RI and BP-PACNS were enrolled from 2 retrospective multicenter cohorts. Patients with CAA-RI were biopsy-positive or met probable clinicoradiologic criteria. Patients with BP-PACNS had histopathologic confirmation of CNS angiitis, with no secondary etiology. A neuroradiologist read brain MRIs, blinded to the diagnosis of CAA-RI or BP-PACNS. Clinicoradiologic features were compared using univariable logistic regression models. Relapse rates were compared using a univariable Fine-Gray subdistribution hazard model, with death as a competing risk. Results This study enrolled 104 patients with CAA-RI (mean age 73 years, 48% female sex) and 52 patients with BP-PACNS (mean age 45 years, 48% female sex). Patients with CAA-RI more often had white matter hyperintense lesions meeting the probable CAA-RI criteria (93% vs 51%, p < 0.001), acute subarachnoid hemorrhage (15% vs 2%, p = 0.02), cortical superficial siderosis (27% vs 4%, p < 0.001), ≥1 lobar microbleed (94% vs 26%, p < 0.001), past intracerebral hemorrhage (17% vs 4%, p = 0.04), ≥21 visible centrum semiovale perivascular spaces (34% vs 4%, p < 0.01), and leptomeningeal enhancement (70% vs 27%, p < 0.001). Patients with BP-PACNS more often had headaches (56% vs 31%, p < 0.01), motor deficits (56% vs 36%, p = 0.02), and nonischemic parenchymal gadolinium enhancement (82% vs 16%, p < 0.001). The prevalence of acute ischemic lesions was 18% in CAA-RI and 22% in BP-PACNS (p = 0.57). The features with the highest specificity for CAA-RI were acute subarachnoid hemorrhage (98%), cortical superficial siderosis (96%), past intracerebral hemorrhage (96%), and ≥21 visible centrum semiovale perivascular spaces (96%). The probable CAA-RI criteria had a 71% sensitivity (95% CI 44%–90%) and 91% specificity (95% CI 79%–98%) in differentiating biopsy-positive CAA-RI from BP-PACNS. The rate of relapse in the first 2 years after remission was lower in CAA-RI than in BP-PACNS (hazard ratio 0.46, 95% CI 0.22–0.96, p = 0.04). Conclusion Clinicoradiologic features differed between patients with CAA-RI and those with BP-PACNS. Specific markers for CAA-RI were hemorrhagic signs of subarachnoid involvement, past intracerebral hemorrhage, ≥21 visible centrum semiovale perivascular spaces, and the probable CAA-RI criteria. A biopsy remains necessary for diagnosis in some cases of CAA-RI. The rate of relapse in the first 2 years after disease remission was lower in CAA-RI than in BP-PACNS.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 23/07/2024
• Auteurs : Roel AaijAhmed Sameh Wagih AbdelmottelebCarlos Abellan BetetaFernando Jesus AbudinénThomas AckernleyAyomide Matthew AdefisoyeBernardo AdevaMarco AdinolfiPatrik Harri AdlarsonChristina AgapopoulouChristine Angela AidalaZiad AjaltouniSimon AkarKazuyoshi AkibaPietro AlbicoccoJohannes AlbrechtFederico AlessioMichael AlexanderZakariya AliouchePaula Alvarez CartelleRenaud AmalricSandra AmatoJake Lewis AmeyYasmine AmhisLiupan AnLucio AnderliniMartin AnderssonAleksei AndreianovPasquale AndreolaMirco AndreottiDimitra AndreouAlessia AnelliDong AoFlavio ArchilliMatteo ArgentonSergio Arguedas CuendisAlexander ArtamonovMarina ArtusoElie AslanidesMichele AtzeniBenjamin AudurierDavid BacherIrene Bachiller PereaSebastian BachmannMarie BachmayerJohn BackPablo Baladron RodriguezVladislav BalaguraWander BaldiniHaoran BaoJuan Baptista de Souza LeiteMatteo BarbettiIvanildo Rui BarbosaRoger BarlowMikhail BarnyakovSergey BarsukWilliam BarterMatteo BartoliniJustin BartzFedor BaryshnikovJan-Marc BaselsGiovanni BassiBaasansuren BatsukhAurelio BayAnja BeckMaik BeckerFranco BedeschiIgnacio BediagaSamuel BelinViolaine BelleeKonstantin BelousIlia BelovIvan BelyaevGaya BenaneGiovanni BencivenniEli Ben-HaimAlexander BerezhnoyRoland BernetSergi Bernet AndresAlessandro BertolinChristopher BetancourtFederico BettiJosh BexIaroslava BezshyikoJihyun BhomMartin Stefan BiekerNicolo Vladi BiesuzPierre BilloirAlice BiolchiniMatthew BirchFionn Caitlin Ros BishopAlexander BitadzeAndrea BizzetiThomas BlakeFrederic BlancJonah Evan BlankSteven BluskVladimir BocharnikovJulian Alexander BoelhauveOscar Boente GarciaThomas BoettcherAbhishek BohareAlexey BoldyrevCarolina BolognaniRiccardo BolzonellaNikolay BondarFederica BorgatoSilvia BorghiMartino BorsatoJozef Tomasz BorsukSonia Amina BouchibaThemistocles BowcockAlexandre BoyerConcezio BozziMatthew John BradleyAlexandre Brea RodriguezNils BreerJolanta BrodzickaArnau Brossa GonzaloJames David BrownDavide BrunduEmma BuchananAnnarita BuonauraLaura BuonincontriAodhan Tomas BurkeChristopher BurrAnatoly ButkevichJordy Sebastiaan ButterJan BuytaertWiktor ByczynskiSandro CadedduHao CaiRoberto CalabreseSaul Calderon RamirezLukas CaleficeStefano CaliMarta CalviMiriam Calvo GomezPatricia Camargo MagalhaesJose Ivan Cambon BouzasPierluigi CampanaDaniel Hugo Campora PerezAngel Fernando Campoverde QuezadaSimone CapelliLorenzo CapriottiRonald Gerardo Caravaca-MoraAngelo CarboneLidia Carcedo SalgadoRoberta CardinaleAlessandro CardiniPaolo CarnitiLeon David CarusAdrian Casais VidalRowina CasparyGianluigi CasseJorge Castro GodinezMarco CattaneoGiovanni CavalleroViola CavalliniSara CelaniDaniel CervenkovSara CesareAbbie Jane ChadwickIbrahim ChahrourMatthew CharlesPhilippe CharpentierCarlos Alberto Chavez BarajasMaximilien ChefdevilleChen ChenShanzhen ChenZewen ChenAleksei ChernovSerhii ChernyshenkoVeronika ChobanovaSerhii CholakMarcin ChrzaszczAleksei ChubykinVladimir ChulikovPaolo CiambroneXabier Cid VidalGregory CiezarekPierfrancesco CifraPeter ClarkeMarco ClemencicHarry CliffJoel ClosierCarlos Eduardo Cocha ToapaxiVictor CocoJulien CoganEric CognerasLucian CojocariuPaula CollinsTommaso ColomboAlbert Comerma-MontellsLiliana CongedoAndrea ContuNaomi CookeImanol CorredoiraAnthony CorreiaGloria CortiJosephine Jane Cottee MeldrumBenjamin CouturierDaniel Charles CraikMelissa Maria Cruz TorresEsteban Curras RiveraRobert CurrieCesar Luiz da SilvaShakhzod DadabaevLingyun DaiXinchen DaiElena Dall'OccoJeremy DalsenoCarmelo d'AmbrosioJessy DanielAnna DanilinaPhilippe d'ArgentAlexander DavidsonJonathan Edward DaviesAdam DavisOscar de Aguiar FranciscoCamilla de AngelisFederico de BenedettiJan de BoerKristof de BruynStefano de CapuaMichel de CianUlisses de Freitas Carneiro da GracaErika de LuciaJussara de MirandaLeandro de PaulaMarilisa de SerioPatrizia de SimoneFabio de VellisJacco de VriesFrancesco DebernardisDaniel DecampVlad-George DeduLuigi del BuonoBlaise DelaneyHans Peter DembinskiJianqiao DengVadym DenysenkoOlivier DeschampsFrancesco DettoriBiplab DeyPasquale Di NezzaIgor DiachkovSergey DidenkoShuchong DingLucas DittmannVasyl DobishukAleksandrina DochevaChenzhi DongAmanda May DonohoeFrancesca DordeiAlberto dos ReisAndrew Jay DowlingWeisong DuanPiotr Jakub DudaMaciej Wojciech DudekLaurent DufourViacheslav DukPaolo DuranteMaciej DurasJohn Matthew DurhamOzgur DurmusAgnieszka DziurdaAlexey DzyubaSajan EasoEllinor EcksteinUlrik EgedeArtem EgorychevVictor EgorychevStephan EisenhardtEnoch EjopuLars EklundMohamed ElashriJan Hendrik EllbrachtScott ElyAlexandru EneEliane EppleJonas Nathanael EschleSevda EsenTimothy EvansFederica FabianoLucas FalcaoYanting FanBo FangLisa FantiniMaria FariaKeira Gwyn FarmerDavide FazziniLukasz Jerzy FelkowskiMingjie FengMauricio FeoMiguel Fernandez GomezAlex Daniel FernezFabio FerrariFernando Ferreira RodriguesMartina FerrilloMassimiliano Ferro-LuzziSergey FilippovRosa Anna FiniMassimiliano FioriniKamil Leszek FischerDillon Scott FitzgeraldConor FitzpatrickFrederic FleuretMarianna FontanaLucas Arthur ForemanRoger FortyDaniel Foulds-HoltManuel Franco SevillaMarkus FrankEdoardo FranzosoGiulia FrauChristoph FreiDavid Anthony FridayJinlin FuQuentin FuehringYuki FujiiTommaso FulghesuEmmy GabrielGiuliana GalatiMaria Domenica GalatiAbraham Gallas TorreiraDomenico GalliSilvia GambettaMiriam GandelmanPaolo GandiniBilal Ahmad GanieHan GaoRui GaoYang GaoYuanning GaoYuxi GaoMichela GarauLuis Miguel Garcia MartinPaula Garcia MorenoJulián García PardiñasKunal GargLluis GarridoClara GasparRobbert Erik GeertsemaLouis Lenard GerkenEvelina GersabeckMarco GersabeckTimothy GershonZahra GhorbanimoghaddamLuca GiambastianiFotis Ioannis GiasemisValerie GibsonHenryk Karol GiemzaAlexander Leon GilmanMatteo GiovannettiAlessandra GioventùPere Gironella GironellCarmen GiuglianoMaciej Artur GizaEvangelos Leonidas GkougkousisFabian Christoph GlaserVladimir GligorovCarla GöbelElisabet GolobardesDmitry GolubkovAndrey GolutvinAlvaro GomesSergio Gomez FernandezFernanda Goncalves AbrantesMateusz GoncerzGuanghua GongJames Andrew GoodingIgor Vladimirovich GorelovClaudio GottiJascha Peter GrabowskiLuis Alberto Granado CardosoEugeni GraugésElena GraveriniLuke GrazetteGiacomo GrazianiAlexandru Tudor GrecuLex Marinus GreevenNathan Allen GrieserLucia GrilloSergey GromovChenxi GuMarco GuariseManuel GuittiereVasilisa GuliaevaPaul Andre GüntherAbdul-Kerim GuseinovEvgeny GushchinYury GuzThierry GysKai Sebastian HabermannThomas HadavizadehChristos HadjivasiliouGuido HaefeliChristophe HaenJakob HaimbergerMohammadtaghi HajheidariMarius Maehlum HalvorsenPhoebe Meredith HamiltonJan HammerichQundong HanXiaoxue HanStephanie Hansmann-MenzemerLei HaoNeville HarnewMarie HartmannJibo HeFrederic HemmerConor HendersonRiley Dylan Leslie HendersonArthur Marius HennequinKarol HennessyLouis HenryJames Daniel HerdPaula Herrero GasconJohannes HeuelAdlène HicheurGuillermo Hijano MendizabalDonal HillSophie HollittJoshua Ethan HorswillRuiwen HouYingrui HouNed Francis HowarthJiangqiao HuJifeng HuWenhua HuXiaofan HuWenqian HuangWouter HulsbergenRoss John HunterMikhail HushchynDavid HutchcroftDmitrii IlinPhilip IltenAlexander InglessiAleksandr IniukhinArtur IshteevKuzma IvshinRichard JacobssonHendrik JageSergio Javier Jaimes EllesSune JakobsenEddy JansBrij Kishor JashalAbolhassan JawaheryVukan JevticEmily Kaiyin JiangXiaojie JiangYi JiangYuyang JiangMalcolm JohnDaniel JohnsonChristopher JonesThomas Peter JonesSalil JoshiBeat JostNathan JurikIzabela JuszczakDimitrios KaminarisSergii KandybeiYouen KangChandiprasad KarMatthias KaracsonDmitrii KarpenkovAnni KauniskangasJacob William KautzFloris KeizerMatthew KenzieTjeerd KetelBasem KhanjiAnastasiia KharisovaSergei KholodenkoGaelle KhreichThomas KirnVeronica Soelund KirsebomOuail KitouniSuzanne KlaverNico KleijneKonrad KlimaszewskiMateusz Rafal KmiecSerhii KoliievLars KolkAnatoly KonoplyannikovPawel KopciewiczPatrick KoppenburgMikhail KorolevIgor KostiukOleksander KotSofia KotriakhovaAnastasiia KozachukPolina KravchenkoLeonid KravchukMichal KrepsPavel KrokovnyWojciech KrupaWojciech KrzemienOleksandr KshyvanskyiJakub KubatSebastian Antoni KubisMarcin KucharczykVasily KudryavtsevEvgenia KulikovaAndrzej KupscBogdan KutsenkoDaniel LacarrereAdriano LaiAndrea LampisDavide LancieriniClara Landesa GomezJohn Jake LaneRichard LaneChristoph LangenbruchJan LangerOliver LantwinThomas LathamFederico LazzariCristina LazzeroniRenaud Le GacRegis LefèvreAlexander LeflatSergey LegotinMarion LehurauxEdgar Lemos CidOlivier LeroyTadeusz LesiakBlake LeveringtonAnfeng LiHengne LiKechen LiLanxing LiPeilian LiPei-Rong LiQinze LiShiyang LiTiange LiTianqi LiYanru LiYiming LiZhengchen LianXixin LiangSimone LibralonChuangxin LinTai-Hua LinRolf LindnerVitalii LisovskyiRoman LitvinovFrank Xiangyu LiuGuoming LiuKai LiuShuaiyi LiuYiming LiuYing LiuYiwei LiuAniol Lobo SalviaAngelo LoiJulian Lomba CastroThomas LongJose LopesAlbert Lopez HuertasSaúl López SoliñoChiara LucarelliDonatella LucchesiMiriam Lucio MartinezValeriia LukashenkoYiheng LuoAnna LupatoEleonora LuppiKate LynchXiao-Rui LyuGe MaRuiting MaSerena MaccoliniFrederic MachefertFlorin MaciucBridget MackInnes MackayLauren Grace MackeyLakshan Ram Madhan MohanMarcus Jonathan MaduraiArtem MaevskiyDaniel MagdalinskiDmitrii MaisuzenkoMaciej Witold MajewskiJakub Jacek MalczewskiSneha MaldeLorenzo MalentaccaAlexander MalininTimofei MaltsevGiulia MancaGiampiero MancinelliChiara MancusoRafel Manera EscaleroDaniele ManuzziDaniele MarangottoJean François MarchandRadoslav MarchevskiUmberto MarconiSaverio MarianiCarla Marin BenitoJörg MarksAlexander Mclean MarshallGabriele MartelliGiuseppe MartellottiLoris MartinazzoliMaurizio MartinelliDiego Martinez SantosFernando Martinez VidalAndré MassafferriRosen MatevAbhijit MathadViacheslav MatiuninClara MatteuzziKara Renee MattioliAndrea MauriEmilie MauriceJoan MauricioPierre Paul Louis MayencourtMichal MazurekMichael MccannLucas McconnellTamaki Holly McgrathNiall Thomas MchughAndrew McnabRonan McnultyBrian MeadowsGerwin MeierDmytro MelnychukFanjie MengMarcel MerkAndrea MerliLucas Meyer GarciaDexing MiaoHan MiaoMikhail MikhasenkoDiego Alejandro MilanesAlessandro MinottiElisa MinucciTristan MirallesBiljana MitreskaDominik Stefan MitzelAtanu ModakAntje MöddenRizwaan Adeeb MohammedRazvan-Daniel MoiseSergei MokhnenkoTitus MombächerMatthew David MonkStephane MonteilAngel Morcillo GomezGianfranco MorelloMichael Joseph MorelloMaurice Pierre MorgenthalerAdam Benjamin MorrisAndrew George MorrisRaymond MountainHongjie MuZeqing MuEmir MuhammadFranz MuheimMick MulderKatharina MüllerFederico Muñoz-RojasRebecca MurtaParas NaikTatsuya NakadaRaja NandakumarTara NanutIrina NastevaMatthew NeedhamNicola NeriSebastian NeubertNiko NeufeldPetr NeustroevJanina NicoliniDavide NicotraElisabeth Maria NielNikolay NikitinPedro NogarolliPiet NoggaNiklas Stefan NolteCamille NormandJulio Novoa FernandezGabriel Matthew NowakCynthia NunezHavva Hasret NurAgnieszka Oblakowska-MuchaVladimir ObraztsovThomas OeserShinichi OkamuraArtem OkhotnikovOleksandr OkhrimenkoRudolf OldemanFederica OlivaMicol OloccoGerco OnderwaterRyunosuke Hugo O'NeilJuan Martin Otalora GoicocheaPatrick OwenMaria Aranzazu OyangurenOzlem OzcelikKlaas Ole PadekenBhagyashree PagarePreema Rennee PaisTommaso PajeroAntimo PalanoMatteo PalutanGennady PanshinLorenzo PaolucciAntonios PapanestisMarco PappagalloLuciano PappalardoCheryl PappenheimerChristopher ParkesBarbara PassalacquaGiovanni PassalevaDaniele PassaroAlessandra PastoreMitesh PatelJairus Tristan PatocClaudia PatrignaniAntara PaulChristopher James PawleyAntonio PellegrinoJi PengMonica Pepe AltarelliStefano PerazziniDmitrii PereimaHugo Pereira da CostaAsier Pereiro CastroPascal PerretAlberto PerroKonstantinos PetridisAlessandro PetroliniJacob PfallerHang PhamLorenzo PicaMauro PicciniBoleslaw PietrzykGuillaume PietrzykDavide PinciFlavio PisaniMarco PizzichemiVlad-Mihai PlacintaMaximo Plo CasasusFrancesco PolciMarco Poli LenerAnton PoluektovNatalia PolukhinaIvan PolyakovErica PolycarpoSebastien PonceDmitry PopovStanislav PoslavskiiKodassery PrasanthClaire ProuveValery PugatchGiovanni PunziShah Rukh QasimWenbin QianNing QinSanqiang QuRenato QuaglianiRaul Iraq Rabadan TrejoJonas RademackerMatteo RamaManuel Ramírez GarcíaVictoria Ramos de OliveiraMiguel Ramos PernasMurilo RangelFedor RatnikovGerhard RavenMiguel Rebollo de MiguelFederico RediJake ReichFlorian ReissZan RenP.K ResmiRoberto RibattiGabriel RicartDomenico RiccardiStefania RicciardiKate Abigail RichardsonMary Richardson-SlipperKurt RinnertPatrick RobbeGary RobertsonEduardo RodriguesEmilio Xose Rodriguez FernandezJairo Alexis Rodriguez LopezEfren Rodriguez RodriguezAlexander RogovskiyDavid Leonhard RolfPhilipp RoloffVladimir RomanovskiyMarcos Romero LamasAntonio Romero VidalGabriele RomoliniFederico RonchettiMarcello RotondoShreya RoyMatthew Scott RudolphThomas RufMiguel Ruiz DiazRamon Angel Ruiz FernandezJoan Ruiz VidalArtem RyzhikovJakub RyzkaJose Javier Saavedra-AriasJuan Jose Saborido SilvaRita SadekNaylya SagidovaDebashis SahooNiladribihari SahooBiagio SaittaMatteo SalomoniCristina Sanchez GrasIzaac SanderswoodRoberta SantacesariaCibran Santamarina RiosMarco SantimariaLeonardo SantoroEmanuele SantovettiAlessandro SaputiDanila SaraninGediminas SarpisMindaugas SarpisCelestina SatrianoAlessia SattaMiroslav SaurDarya SavrinaHalime SazakLuke George Scantlebury SmeadAlessandro ScarabottoStefan SchaelSigrid ScherlManuel SchillerHeinrich SchindlerMichael SchmellingBurkhard SchmidtSebastian SchmittHannah SchmitzOlivier SchneiderAndreas SchopperNicole SchulteSebastian SchulteMarie Helene SchuneRainer SchwemmerGeorg SchweringBarbara SciasciaAugusto SciuccatiSara SellamAlexander SemennikovThomas Christian SengerMara Senghi SoaresAntonino SergiNicola SerraLorenzo SestiniAlex SeutheYiduo ShangDesmond Mzamo ShangaseMikhail ShapkinRashi SharmaIvan ShchemerovLesya ShchutskaTara ShearsLev ShekhtmanZhihong ShenShuqi ShengVladimir ShevchenkoBoan ShiQi ShiEdward Brendan ShieldsYuya ShimizuEvgenii ShmaninRoman ShorkinJoseph David ShupperdRafael Silva CoutinhoGabriele SimiSaverio SimoneNicola SkidmoreTomasz SkwarnickiMark SlaterJennifer Clare SmallwoodEluned SmithKrista Lizbeth SmithMark SmithAleksandra SnochLais Soares LavraMichael SokoloffPaul SolerAnatoly SolominAleksandr SolovevIvan SolovyevRongrong SongYunxuan SongYuxiang SongYintong SongFelipe Luan Souza de AlmeidaBruno Souza de PaulaElisabetta Spadaro NorellaEugenia SpedicatoJannis Guido SpeerEduard SpiridenkovPatrick SpradlinViros SriskaranFederico StagniMarian StahlSascha StahlSeophine StanislausEloise Noelle SteinOlaf SteinkampOleg StenyakinHolger StevensDaria StrekalinaYangjie SuFidan SuljikJiayin SunLiang SunYipeng SunDaniel Sundfeld LimaWilliam SutcliffePaul Nathaniel SwallowFrancesca SwystunAdam SzabelskiTomasz SzumlakYinghua TanMartin Duy TatAleksandr TerentevFrancesco TerzuoliFrederic TeubertEric ThomasDaniel James David ThompsonHanae TilquinVincent TisserandStephane t'JampensMark TobinLuca TomassettiGiorgia TonaniXingyu TongDiego Torres MachadoLuca Toscanoda Yu TouCarina TripplGiulia TuciNiels TuningLennart Henning UeckerArtur UklejaDaniel Joachim UnverzagtEduard UrsovAndrii UsachovAndrey UstyuzhaninUlrich UwerVincenzo VagnoniAndrea ValassiGiovanni ValentiNuria Valls CanudasHubert van HeckeEric van HerwijnenCharlotte Barbara van HulseRaphael van LaakMaarten van VeghelGerardo VasquezRicardo Vazquez GomezPablo Vazquez RegueiroCarlos Vázquez SierraStefania VecchiJaap VelthuisMichele VeltriAravindhan VenkateswaranMika VesterinenMaria Vieites DiazXavier Vilasis-CardonaEva Vilella FiguerasAndrea VillaPascal VincentFelicia Carolin VolleDorothea Vom BruchNikolai VoropaevKimberley VosGuillaume VoutersConstantinos VrahasJan Peter WagnerJohn WalshEliot Jane WaltonGuanyue WanChishuai WangGanrong WangJialu WangJianchun WangJianqiao WangJike WangMengzhen WangNanyang WangRui WangXiao WangXiaolin WangXiaohan WangZhenzi WangZirui WangZiyi WangJake Alexander WardMark WaterlaatNigel WatsonDavid WebsdaleYajing WeiJohn WendelBenedict Donald C WesthenryDylan Jaide WhiteMark WhiteheadAidan Richard WiederholdDirk WiednerGuy WilkinsonMichael K WilkinsonMike WilliamsMark Richard James WilliamsRichard Morgan WilliamsFergus WilsonWojciech WislickiMariusz WitekLukas WitolaCheuk Ping WongGuy WormserStephen WottonHangyi WuJie WuYanxi WuKenneth WyllieShu XianZhiyu XiangYuehong XieAo XuJingyi XuLi XuLiangjun XuMenglin XuZehua XuZhihao XuZijun XuDi YangKang YangShuangli YangXueting YangYouhua YangZhenwei YangZishuo YangVsevolod YeroshenkoHo Yin Dereck YeungHang YinChenxu YuJiesheng YuXuhao YuanEttore ZaffaroniMikhail ZavertyaevMilosz ZdybalCheng ZengMing ZengChenjia ZhangDongliang ZhangJianyu ZhangLiming ZhangShulei ZhangShunan ZhangYanxi ZhangYuge ZhangYa ZhaoAlina ZharkovaAlexey ZhelezovXutao ZhengYangheng ZhengTianwen ZhouXiaokang ZhouYixiong ZhouValeriia ZhovkovskaLinxuan ZhuXianglei ZhuXiaoyu ZhuValery ZhukovJiahui ZhuoQuan ZouDavide ZulianiGianluca Zunica
• Organismes : Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire Leprince-Ringuet Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire Leprince-Ringuet Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie

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Résumé : A search for the nonresonant $\Lambda_c^+ \to p \mu^+ \mu^-$ decay is performed using proton-proton collision data recorded at a centre-of-mass energy of 13 TeV by the LHCb experiment, corresponding to an integrated luminosity of 5.4 fb$^{-1}$. No evidence for the decay is found in the dimuon invariant-mass regions where the expected contributions of resonances is subdominant. The upper limit on the branching fraction of the $\Lambda_c^+ \to p \mu^+ \mu^-$ decay is determined to be $2.9~(3.2) \times 10^{-8}$ at 90% (95%) confidence level. The branching fractions in the dimuon invariant-mass regions dominated by the $\eta$, $\rho$ and $\omega$ resonances are also determined.

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2024
• Auteurs : Olivier DecauxRonan GarlantézecKarim Belhadj-MerzougMargaret MacroLaurent FrenzelAurore PerrotPhilippe MoreauBruno RoyerDenis CaillotXavier LeleuMohamad MohtyLionel KarlinPierre FeugierSophie RigaudeauJean FontanCécile SonntagLaure VincentThomas ChalopinHerve Avet LoiseauZakaria MaaroufLouni ChanazNathalie TexierCyrille Hulin
• Organismes : Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] CHU Henri Mondor [Créteil] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Imagine - Institut des maladies génétiques (IHU) Institut Universitaire du Cancer de Toulouse - Oncopole Laboratoire d'Automatique, de Mécanique et d'Informatique industrielles et Humaines - UMR 8201 Hopital Saint-Louis [AP-HP] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Ischémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Sorbonne Université CHU Saint-Antoine [AP-HP] Centre Hospitalier Lyon Sud [CHU - HCL] Immuno-Biologie des Lymphomes [CIRI] Service d'Hématologie [CHRU Nancy] Nutrition-Génétique et Exposition aux Risques Environnementaux Centre Hospitalier de Versailles André Mignot Service d'hématologie Hôpital de Hautepierre [Strasbourg] CHU Montpellier = Montpellier University Hospital Centre Hospitalier Régional Universitaire de Tours Institut Universitaire du Cancer de Toulouse - Oncopole Intergroupe francophone du myélome Intergroupe francophone du myélome Kappa Santé Hôpital Haut-Lévêque [CHU Bordeaux]
• Publié dans Clinical Hematology International le 16/03/2021

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Résumé : The therapeutic management of patients with multiple myeloma (MM) is complex. Despite substantial advances, MM remains incurable, and management involves cycles of treatment response, disease relapse, and further therapy. Currently, evidence to support the therapeutic decision is limited. Thus, the EMMY longitudinal, real-world study was designed to annually assess therapeutic management of MM in France to provide evidence to support physicians. During an annual prespecified 3-month recruitment period, eligible patients will be identified from their medical records. Adults aged ≥18 years diagnosed with symptomatic MM and requiring systemic treatment will be eligible. The primary objective, the evolution of MM therapeutic management, will be described, as well as the impact on the following outcomes: time-to-next treatment (TTNT), progression-free survival (PFS), and overall survival (OS). The study plans to recruit 5000 patients over 6 years: 700 to 900 patients annually. EMMY is a unique opportunity to collect real-world data to describe the evolving MM therapeutic landscape and record outcomes in France. These data will provide annual snapshots of various aspects of MM management. This knowledge will provide physicians with real-life, evidence-based data for therapeutic decision-making and ultimately improve treatment for MM patients.

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Fichiers liés : chi_2024_6_3_121371.pdf

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• Type de publi. : Rapport
• Date de publi. : 22/07/2024
• Auteurs : Jean-Claude GregoireMartin GodefroidHervé JactelRaphaëlle MouttetCecile RobinAlain RoquesThomas E BourgeoisPhilippe Castagnone-SerenoThierry CandresseNicolas DesneuxSandrine EveillardFlorence FontainePascal GentitLucia GuerinBruno HostachyKazakou EleniChristophe Le MayEric LombaertDavid MakowskiCharles ManceauBenoit MarçaisArnaud MontyMaria Navajas NavarroAurélien SalleFrédéric SuffertStéphan SteyerPierre-Yves TeycheneyEric VerdinFrançois VerheggenEmmanuel GachetXavier Tassus
• Organismes : Université libre de Bruxelles Museo Nacional de Ciencias Naturales [Madrid] Biodiversité, Gènes & Communautés Laboratoire de la santé des végétaux Biodiversité, Gènes & Communautés Zoologie forestière Botanique et Modélisation de l'Architecture des Plantes et des Végétations Institut Sophia Agrobiotech Biologie du fruit et pathologie Institut Sophia Agrobiotech Biologie du fruit et pathologie Université de Reims Champagne-Ardenne Laboratoire de la santé des végétaux Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine Institut Agro - Montpellier SupAgro Institut Agro Rennes Angers Institut Sophia Agrobiotech Mathématiques et Informatique Appliquées Interactions Arbres-Microorganismes Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Centre de Biologie pour la Gestion des Populations Université d'Orléans BIOlogie et GEstion des Risques en agriculture Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Centre wallon de Recherches Agronomiques [Belgique] = Walloon Agricultural Research Centre [Belgium] Centre de Coopération Internationale en Recherche Agronomique pour le Développement Unité de Pathologie Végétale Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire de la santé des végétaux Laboratoire de la santé des végétaux

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Résumé : Dans le cadre de la surveillance des organismes réglementés ou émergents (SORE), un dispositif de piégeage a été déployé par la DGAL en 2021 avec l’appui de l’INRAE et de l’ONF. L’objectif de ce dispositif est d’effectuer une surveillance passive dans les sites d’entrée potentiels (ports, aéroports, marché d’intérêt national (MIN)) des organismes réglementés ou émergents (SORE). Ce piégeage est qualifié de « large spectre » car il peut concerner plusieurs filières de production suivies dans le cadre de la SORE (forêts, jardins et espaces verts et infrastructures (JEVI), arboriculture fruitière) en ciblant cependant majoritairement les insectes coléoptères des ligneux. Les principes de la surveillance mise en œuvre s’appuient sur les résultats précédemment acquis dans le cadre du projet PORTRAP, utilisant des pièges génériques multi-composés pour la détection précoce d’insectes exotiques xylophages dans les sites potentiels d’entrée sur le territoire national. Les pièges ont été disposés sur 13 sites (7 ports maritimes, 1 port fluvial, 4 aéroports et 1 marché national) dispersés sur le territoire (France métropolitaine continentale). Au total 9279 individus appartenant à 110 espèces différentes ont été capturés. Aucune espèce d’insecte de quarantaine prioritaire n’a été piégée. En revanche, la présence d’individus appartenant à 8 espèces de coléoptères exotiques, a priori non présents sur notre territoire, des familles Cerambycidae et Curculionidae (sous-familles des Scolytinae et Platypodinae) a été relevée. Les 8 espèces d’insectes exotiques sont les suivantes : - Cerambycidae : Cordylomera spinicornis (Fabricius, 1775), Trichoferus campestris (Faldermann, 1835), Xylotrechus chinensis (Chevrolat, 1852), Xylotrechus stebbingi Gahan, 1906 ; - Curculionidae : Amasa sp. near truncata, Euplatypus hintzii (Schaufuss, 1897), Euplatypus parallelus (Fabricius, 1801), Xyleborus affinis Eichhoff, 1868.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/07/2024
• Auteurs : Ameena GogaTrisha RamrajLogashvari NaidooBrodie DanielsMasefetsane MatlouTerusha ChettyReshmi DassayeNobubelo K NganduLaura GalliTarylee ReddyIshen SeocharanQondeni NdlangamandlaQholokazi SeptemberNokwanda NgcoboMayuri ReddyTamon Cafun-NaidooKubashni WoeberNitesha JeenarainRabia ImamdinKeshnee MaharajhAshmintha RamjethThobile BhenguEmma ClarencePhilippe Van De PerreThorkild TylleskärNicolas NagotJean-Pierre MolesPenny L MooreNonhlanhla N MkhizeLucio GamaStefania DispinseriPriscilla BiswasGabriella Scarlatti
• Organismes : South African Medical Research Council [Cape Town, South Africa] University of Pretoria [South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] IRCCS Ospedale San Raffaele [Milan, Italy] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] South African Medical Research Council [Cape Town, South Africa] Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital University of Bergen Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] Centre for the AIDS Programme of Research [Durban, South Africa] University of the Witwatersrand [Johannesburg] National Institute for Communicable Diseases [Johannesburg] National Institute of Allergy and Infectious Diseases [Bethesda] IRCCS Ospedale San Raffaele [Milan, Italy] IRCCS Ospedale San Raffaele [Milan, Italy] IRCCS Ospedale San Raffaele [Milan, Italy]
• Publié dans BMC Infectious Diseases le 01/11/2020

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Résumé : Background: The ambitious goal to eliminate new pediatric HIV infections by 2030 requires accelerated prevention strategies in high-risk settings such as South Africa. One approach could be pre-exposure prophylaxis (PrEP) with broadly neutralizing anti-HIV-1 monoclonal antibodies (bNAbs). The aim of our study is to define the optimal dose(s), the ideal combination(s) of bNAbs in terms of potency and breadth, and timing of subcutaneous (SC) administration(s) to prevent breast milk transmission of HIV. Methods: Two bNAbs, CAP256V2LS and VRC07-523LS, will be assessed in a sequential and randomized phase I, single-site, single-blind, dose-finding trial. We aim to investigate the 28-day safety and pharmacokinetics (PK) profile of incrementally higher doses of these bNAbs in breastfeeding HIV-1 exposed born without HIV neonates alongside standard of care antiretroviral (ARV) medication to prevent (infants) or treat (mothers) HIV infection. The trial design includes 3 steps and 7 arms (1, 2, 3, 4, 5, 6 and 6b) with 8 infants in each arm. The first step will evaluate the safety and PK profile of the bNAbs when given alone as a single subcutaneous (SC) administration at increasing mg/kg body weight doses within 96 h of birth: arms 1, 2 and 3 at doses of 5, 10, and 20 mg/kg of CAP256V2LS, respectively; arms 4 and 5 at doses of 20 and 30 mg/kg of VRC07-523LS, respectively. Step two will evaluate the safety and PK profile of a combination of the two bNAbs administered SC at fixed doses within 96 h of birth. Step three will evaluate the safety and PK profile of the two bNAbs administered SC in combination at fixed doses, after 3 months. Arms 1 and 6 will follow sequential recruitment, whereas randomization will occur sequentially between arms (a) 2 & 4 and (b) 3 & 5. Before each randomization, a safety pause will allow review of safety data of the preceding arms. Discussion: The results of this trial will guide further studies on bNAbs to prevent breast milk transmission of HIV.

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Fichiers liés : s12879-024-09588-3.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 19/07/2024
• Auteurs : Cyril GrandjeanChristophe VéronésiChristine RusterucciCharlotte GautierYanis MaillotMaïté LeschevinFrançoise FournetJan DrouaudPaulo MarceloLuciane ZabijakPhilippe DelavaultPhilippe SimierSophie BoutonKarine Pageau
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Unité en Sciences Biologiques et Biotechnologies de Nantes BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment BioEcoAgro - UMR transfrontalière INRAe - UMRT1158 BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment BioEcoAgro - UMR transfrontalière INRAe - UMRT1158 Plateforme d’Ingénierie Cellulaire et Analyses des Protéines - UPJV Plateforme d’Ingénierie Cellulaire et Analyses des Protéines - UPJV Unité en Sciences Biologiques et Biotechnologies de Nantes Unité en Sciences Biologiques et Biotechnologies de Nantes BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment BioEcoAgro BIOPI-UPJV BioEcoAgro - Equipe 1 - Functioning and adaptation of the plant in interaction with its environment

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Résumé : Phelipanche ramosa is a root parasitic plant fully dependent on host plants for nutrition and development. Once germinated, the parasitic seedling develops inside of the infected roots a specific organ, the haustorium, thanks to notably cell wall degrading enzymes of haustorial intrusive cells and induced modifications in host’s cell walls. The model plant Arabidopsis thaliana is susceptible to P. ramosa, thus mutants in cell wall metabolism, notably in pectin remodeling like Atpme3-1, are of interest in studying the involvement of cell wall degrading host’s enzymes in establishment of the plant-plant interaction. Host-parasite co-cultures in mini-rhizotrons systems revealed that parasite attachments are twice more numerous and tubercle growth is quicker on Atpme3-1 roots than on WT roots. When compared to the WT, increase in susceptibility in the mutant is associated to reduction in PME activity in roots and to lowering in the degree of pectin methylation at the host-parasite interface, as detected immunohistochemically in infected roots. In addition, both WT and Atpme3-1 responded to infestation by modulations in expression of PAE and PME encoding genes and in global related enzymes activities in roots, before and after parasite attachment. However, modulations differ in WT and Atpme3-1 and this may contribute to different pectin remodeling in roots and contrasted susceptibility to P. ramosa. By this integrative study, we could define a model of the cell wall response to this particular biotic stress and indicate for the first time the role of PME3 in this parasitic plant-plant interaction.

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• Type de publi. : Article dans une revue
• Date de publi. : 18/07/2024
• Auteurs : Coralie BarreraCarsten SchwarzLaurence DelhaesSolène Le GalSophie RamelJean-Pierre GangneuxJuliette GuitardClaire HoffmannAnne-Pauline BellangerJean-Philippe BoucharaLaurence Millon
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Charité - UniversitätsMedizin = Berlin University Medicine Centre Hospitalier Universitaire de Bordeaux SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] Fondation ILDYS Institut de recherche en santé, environnement et travail Centre de Recherche Saint-Antoine SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire Chrono-environnement (UMR 6249) SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie-Mycologie, CHU d'Angers, Angers, Centre Hospitalier Universitaire d'Angers Laboratoire Chrono-environnement (UMR 6249)
• Publié dans Mycopathologia le 31/10/2020

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Résumé : Context: Allergic bronchopulmonary mycoses (ABPM) can be due to molds other than Aspergillus fumigatus in patients with cystic fibrosis (pwCF). We aimed to develop immunoassays for the detection of specific IgE (sIgE) directed against five fungal species involved in ABPM: Aspergillus terreus, Scedosporium apiospermum, Lomentospora prolificans, Rasamsonia argillacea, and Exophiala dermatitidis.Materials and methods: Serum samples (n = 356) from 238 pwCF, collected in eight CF care centers in France, Germany, and Italy, were analyzed by dissociated enhanced lanthanide fluorescent immunoassay (DELFIA®) to assess levels of sIgE directed against antigenic extracts of each fungus. Clinical, biological, and radiological data were collected for each episode. One hundred serum samples from healthy blood donors were used as controls. Sera were classified into four groups depending on the level of sIgE according to the quartile repartition calculated for the pwCF population. A score of 4 for values above the 3rd quartile corresponds to an elevated level of sIgE.Results: PwCF showed higher levels of sIgE than controls. Based on criteria from the ABPA-ISHAM working group, with an additional criterion of "a sIgE score of 4 for at least one non-A. fumigatus mold", we were able to diagnose six cases of ABPM.Conclusions: Using 417 IU/mL as the threshold for total IgE and the same additional criterion, we identified seven additional pwCF with "putative ABPM". Detection of sIgE by DELFIA® showed good analytical performance and supports the role played by non-A. fumigatus molds in ABPM. However, commercially available kits usable in routine practice are needed to improve the diagnosis of ABPM.

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• Type de publi. : Article dans une revue
• Date de publi. : 17/07/2024
• Auteurs : Gabrielle dos Santos IlhaMarianne BoixJürgen KnödlsederPhilippe GarnierLudovic MontastrucP. JeanGiovanni PareschiAlexander SteinerFrançois Toussenel
• Organismes : Institut de recherche en astrophysique et planétologie Laboratoire de Génie Chimique Institut de recherche en astrophysique et planétologie Institut de recherche en astrophysique et planétologie Institut Universitaire de Technologie - Paul Sabatier Laboratoire de Génie Chimique Institut de recherche en astrophysique et planétologie INAF - Osservatorio Astronomico di Brera Deutsches Elektronen-Synchrotron [Zeuthen] Laboratoire de Physique Nucléaire et de Hautes Énergies
• Publié dans Nature Astronomy le 15/02/2017

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Résumé : Astronomical observatories have been identified as substantial contributors to the carbon footprint of astrophysical research. Being part of the collaboration that is currently developing the medium-sized telescopes in the Cherenkov Telescope Array, a ground-based observatory for very-high-energy γ-rays that will comprise 64 telescopes deployed on two sites, we assessed the environmental impacts of one medium-sized telescope on the northern site with a life-cycle assessment. We identified resource use and climate change as having the most significant impacts due to telescope manufacturing and energy consumption during operations. We estimate life-cycle greenhouse gas emissions of 2,660 ± 274 tCO2e for the telescope, 44% of which arise from construction, 1% from on-site assembly and commissioning and 55% from operations over 30 yr. The environmental impacts could be reduced by using renewable energy during construction and operations, using fewer electronic components and metal casting and using recycled materials. We propose complementing the project requirements with environmental budgets as an effective measure for impact management and reductions.

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Fichiers liés : archive.pdf

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