Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/07/2024
• Auteurs : Basile RouxOriol TeixidóChristophe LucchesiJean-Philippe PerezDaniel ChemisanaPierre-Olivier ChapuisRodolphe Vaillon
• Organismes : Institut d’Electronique et des Systèmes Micro électronique, Composants, Systèmes, Efficacité Energétique Composants à Nanostructure pour le moyen infrarouge Matériaux Photonique et Ondes Universitat de Lleida Centre d'Energétique et de Thermique de Lyon Institut d’Electronique et des Systèmes Composants à Nanostructure pour le moyen infrarouge Universitat de Lleida Centre d'Energétique et de Thermique de Lyon Laboratoire d'analyse et d'architecture des systèmes Équipe Photonique

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Fichiers liés : Nanorad2024-one-page_abstract_Vaillon.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2024
• Auteurs : Lei FanTianxiang CuiWigneron J.-P.Philippe CiaisStephen SitchMartin BrandtXin LiShuli NiuXiangming XiaoJérôme ChaveChaoyang WuWei LiWenping YuanZanpin XingXiaojun LiMengjia WangXiangzhuo LiuXiuzhi ChenYuanwei QinHui YangQiang TangYuechen LiMingguo MaRasmus Fensholt
• Organismes : Southwest University [Chongqing] Nanjing Forestry University Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] University of Exeter IT University of Copenhagen Chinese Academy of Sciences [Beijing] Chinese Academy of Sciences [Beijing] University of Oklahoma Evolution et Diversité Biologique Chinese Academy of Sciences [Beijing] Tsing Hua University Peking University [Beijing] Interactions Sol Plante Atmosphère Chinese Academy of Sciences [Beijing] Interactions Sol Plante Atmosphère Zhengzhou University Interactions Sol Plante Atmosphère Sun Yat-sen University [Guangzhou] University of Oklahoma Max Planck Institute for Biogeochemistry Southwest University [Chongqing] Southwest University [Chongqing] Southwest University [Chongqing] IT University of Copenhagen
• Publié dans Global Change Biology le 25/10/2020

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Résumé : The extreme dry and hot 2015/16 El Niño episode caused large losses in tropical live aboveground carbon (AGC) stocks. Followed by climatic conditions conducive to high vegetation productivity since 2016, tropical AGC are expected to recover from large losses during the El Niño episode; however, the recovery rate and its spatial distribution remain unknown. Here, we used low‐frequency microwave satellite data to track AGC changes, and showed that tropical AGC stocks returned to pre‐El Niño levels by the end of 2020, resulting in an AGC sink of Pg C year −1 during 2014–2020. This sink was dominated by strong AGC increases ( Pg C year −1 ) in non‐forest woody vegetation during 2016–2020, compensating the forest AGC losses attributed to the El Niño event, forest loss, and degradation. Our findings highlight that non‐forest woody vegetation is an increasingly important contributor to interannual to decadal variability in the global carbon cycle.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2024
• Auteurs : Delphine MasséThierry CandresseDenis FillouxSébastien MassartNathalie CassamBruno HostachyArmelle MaraisEmmanuel FernandezPhilippe RoumagnacEric VerdinPierre-Yves TeycheneyJean-Michel LettPierre Lefeuvre
• Organismes : Peuplements végétaux et bioagresseurs en milieu tropical Unité Ravageurs et agents pathogènes tropicaux Biologie du fruit et pathologie Plant Health Institute of Montpellier Gembloux Agro-Bio Tech [Faculté universitaire des sciences agronomiques de Gembloux] Unité Ravageurs et agents pathogènes tropicaux Unité Ravageurs et agents pathogènes tropicaux Biologie du fruit et pathologie Plant Health Institute of Montpellier Plant Health Institute of Montpellier Unité de Pathologie Végétale Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical Peuplements végétaux et bioagresseurs en milieu tropical
• Publié dans Viruses le 01/11/2020

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Résumé : The cultivation of pineapple (Ananas comosus) is threatened worldwide by mealybug wilt disease of pineapple (MWP), whose etiology is not yet fully elucidated. In this study, we characterized pineapple mealybug wilt-associated ampeloviruses (PMWaVs, family Closteroviridae) from a diseased pineapple plant collected from Reunion Island, using a high-throughput sequencing approach combining Illumina short reads and Nanopore long reads. Reads co-assembly resulted in complete or near-complete genomes for six distinct ampeloviruses, including the first complete genome of pineapple mealybug wilt-associated virus 5 (PMWaV5) and that of a new species tentatively named pineapple mealybug wilt-associated virus 7 (PMWaV7). Short reads data provided high genome coverage and sequencing depths for all six viral genomes, contrary to long reads data. The 5′ and 3′ ends of the genome for most of the six ampeloviruses could be recovered from long reads, providing an alternative to RACE-PCRs. Phylogenetic analyses did not unveil any geographic structuring of the diversity of PMWaV1, PMWaV2 and PMWaV3 isolates, supporting the current hypothesis that PMWaVs were mainly spread by human activity and vegetative propagation.

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Fichiers liés : 2024_Masse_Viruses.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2024
• Auteurs : Laurence CromerMariana Tiscareno-AndradeSandrine LefrancAurélie ChambonAurélie HurelManon BrogniezJulie GuérinIvan Le MassonGabriele AdamDelphine CharifPhilippe AndreyMathilde Grelon
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Centre d'études européennes et de politique comparée (Sciences Po, CNRS) Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal CEA- Saclay Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Sud - Paris 11 Université Paris-Saclay Agronomie Institut Jean-Pierre Bourgin Agronomie Institut des Sciences des Plantes de Paris-Saclay Institut Jean-Pierre Bourgin - Sciences du végétal Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans Nature Communications le 23/10/2020

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Résumé : Meiotic rapid prophase chromosome movements (RPMs) require connections between the chromosomes and the cytoskeleton, involving SUN (Sad1/UNC-84)-domain-containing proteins at the inner nuclear envelope (NE). RPMs remain significantly understudied in plants, notably with respect to their importance in the regulation of meiosis. Here, we demonstrate that Arabidopsis thaliana meiotic centromeres undergo rapid (up to 500 nm/s) and uncoordinated movements during the zygotene and pachytene stages. RPMs are not affected by altered chromosome organization and recombination but are abolished in the double mutant sun1 sun2 . We also document the changes in chromosome dynamics and nucleus organization during the transition from leptotene to zygotene, including telomere attachment to SUN-enriched NE domains, bouquet formation, and nucleolus displacement, all of which were defective in sun1 sun2 . These results establish A. thaliana as a new model species for studying the functional implications of meiotic RPMs and demonstrate the mechanistic conservation of telomere-led RPMs in plants.

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• Type de publi. :
• Date de publi. : 16/07/2024
• Auteurs : Jean-Philippe DenisPierre-Yves Gomez
• Organismes : Université Paris-Saclay Réseaux Innovation Territoires et Mondialisation EMLyon Business School

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Résumé : Xerfi Canal welcomed Pierre-Yves Gomez, Professor Emeritus at emlyon business school, Institut Français du Gouvernement des Entreprises, to talk about artificial intelligence as an expression of God's need. An interview conducted by Jean-Philippe Denis.

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Fichiers liés : L_I.A._expression_hymermaterialiste_du_besoin_de_Dieu_Pierre_Yves_Gomez_.mp4

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• Type de publi. : Article dans une revue
• Date de publi. : 16/07/2024
• Auteurs : Munib MesinovicXin Ci WongGiri Shan RajahramBarbara Wanjiru CitarellaKalaiarasu PeariasamyFrank van Someren GrevePiero OlliaroLaura MersonLei CliftonChristiana KartsonakiSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelAmal AbrousLara AbsilAndrew AckerShingo AdachiElisabeth AdamEnrico AdrianoDiana AdriãoSaleh Al AgeelShakeel AhmedMarina AielloKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamAngela AlbertiTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriAdam AliImran AliKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouJoão AlvesJoão Melo AlvesRita AlvesJoana Alves CabritaMaria AmaralNur AmiraHeidi AmmerlaanPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoKazi Rubayet AnwarArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalMotohiro AsakiAngel AsensioElizabeth AshleyMuhammad AshrafJean Baptiste AssieAmirul AsyrafAnika AtiqueAm Udara Lakshan AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrNadia BaigJ. Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanValeria BalanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaAudrey BarreletCleide BarrigotoMarie BartoliJoaquín BaruchRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanDehbia BenkerrouSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginGiulia BertoliLorenzo BertolinoSimon BessisAdam BetzSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarClaudia BiancoFarah Nadiah BidinMoirangthem Bikram SinghFelwa Bin HumaidMohd Nazlin Bin KamarudinZeno BisoffiFrançois BissuelPatrick BistonLaurent BitkerJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotLucille BlumbergFilomena BocciaLaetitia BodenesDebby BogaertAnne-Hélène BoivinIsabela BolañosPierre-Adrien BolzeFrançois BompartPatrizia BonelliAurelius BonfasiusDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKevin BouillerLaurence BouilletCamile BouisseThipsavanh BounphiengsyLatsaniphone BountthasavongAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisBianca BoxmaMarielle Boyer-BesseyreMaria BoylanFernando Augusto BozzaAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziDorothy BreenPatrick BreenDavid BrewsterKathy BrickellAlex BrowneShaunagh BrowneNicolas BrozziMarjolein Brusse-KeizerNina BuchtelePolina BugaevaMarielle BuissonDanilo BuonsensoErlina BurhanAidan BurrellIngrid BustosDenis ButnaruAndré CabieSusana CabralEder CaceresCyril CadozRui Caetano GarcêsMia CallahanKate CalligyJose Andres CalvacheCaterina CaminitiJoão CamõesValentine CampanaPaul CampbellJosie CampisiCecilia CanepaMireia CanteroPauline Caraux-PazSheila CárcelChiara Simona CardellinoFilipa CardosoFilipe CardosoNelson CardosoSofia CardosoSimone CarelliFrancesca CarlacciNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonLeonor CarvalhoMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoShelby CerkovnikMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeBounthavy ChaleunphonAdrienne ChanMeera ChandChristelle Chantalat AugerJean-Marc ChapplainCharlotte CharpentierJulie ChasAllegra ChatterjeeJonathan Samuel Chávez IñiguezAnjellica ChenLéo ChenardMatthew Pellan ChengAntoine CheretAlfredo Antonio ChettaThibault ChiarabiniJulian ChicaSuresh Kumar ChidambaramLeong Chin ThoCatherine ChirouzeDavide ChiumelloHwa Jin ChoSung-Min ChoBernard CholleyDanoy ChommanamMarie-Charlotte ChopinTing Soo ChowYock Ping ChowNathaniel ChristyHiu Jian ChuaJonathan ChuaJose Pedro CidadeJosé Miguel Cisneros HerrerosBarbara Wanjiru CitarellaAnna CiulloEmma ClarkeJennifer ClarkeRolando Claure-Del GranadoSara ClohiseyCassidy CodanCaitriona CodyAlexandra CoelhoJennifer ColesMegan ColesGwenhaël ColinMichael CollinsSebastiano Maria ColomboPamela CombsMarie ConnorAnne ConradSofía ContrerasElaine ConwayGraham CookeMary CoplandHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierEmma CostiganCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganCharles Crepy D’orleansCosimo CristellaSabine CroonenGloria CrowlJonathan CrumpClaudina CruzMarc CseteAilbhe CullenMatthew CummingsGer CurleyElodie CurlierColleen CurranPaula CustodioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensDarren DahlyHeidi DaltonJo DaltonSeamus DalyJuliana DamasNick DanemanCorinne DanielEmmanuelle DankwaJorge DantasFrédérick D’aragonMenno de JongGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaCristina de RoseThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardMarie-Pierre DebrayNathalie DecastroWilliam DechertLauren DeconninckRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneNathalie DelfosIonna DeligiannisAndrea Dell’amoreChristelle DelmasPierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtMehul DesaiDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangerAlpha DialloSylvain DiamantisAndré DiasAndrea DiasFernanda Dias da SilvaJuan Jose DiazPriscila DiazRodrigo DiazKévin DidierJean-Luc DiehlWim DieperinkJérôme DimetVincent DinotFara DiopAlphonsine DioufYael DishonFélix DjossouAnnemarie DochertyHelen DohertyArjen DondorpAndy DongChristl DonnellyMaria DonnellyChloe DonohueSean DonohueYoann DonohuePeter DoranCéline DorivalEric D’ortenzioPhouvieng DouangdalaJames Joshua DouglasRenee DoumaNathalie DournonTriona DownerJoanne DowneyMark DowningTom DrakeAoife DriscollMurray DrydenClaudio Duarte FonsecaVincent Dubée DubéeFrançois DubosAudrey Dubot-PérèsAlexandre DucancelleToni DuculanSusanne DudmanAbhijit DuggalPaul DunandJake DunningMathilde DuplaixEmanuele Durante-MangoniLucian DurhamBertrand DussolJuliette DuthoitXavier DuvalAnne Margarita Dyrhol-RiiseSim Choon EanMarco Echeverria-VillalobosGiorgio EconomopoulosSiobhan EganCarla EiraMohamed El SanharawiSubbarao ElapavaluruBrigitte ElharrarJacobien EllerbroekPhilippine EloyTarek ElshazlyIqbal ElyazarIsabelle EnderleTomoyuki EndoChan Chee EngIlka EngelmannVincent EnoufOlivier EpaulardMartina EscherMariano EsperattiHélène EsperouCatarina Espírito SantoMarina Esposito-FareseJoão EstevãoManuel EtienneNadia EttalhaouiAnna Greti EverdingMirjam EversIsabelle FabreMarc FabreAmna FaheemArabella FahyCameron FairfieldZul FakarPedro FariaHanan FateenaArie Zainul FatoniKarine FaureRaphaël FavoryMohamed FayedNiamh FeelyLaura FeeneyJorge FernandesMarília Andreia FernandesSusana FernandesFrançois-Xavier FerrandEglantine Ferrand DevougeJoana FerrãoCarlo FerrariMário FerrazBenigno FerreiraBernardo FerreiraIsabel FerreiraSílvia FerreiraRicard Ferrer-RocaNicolas FerriereCéline FickoClaudia Figueiredo-MelloWilliam FinlaysonJuan FiordaThomas FlamentClara FlateauTom FletcherAline-Marie FlorenceLetizia Lucia FlorioBrigid FlynnDeirdre FlynnFederica FogliazzaClaire FoleyJean FoleyVictor FominTatiana FonsecaPatricia FontelaSimon ForsythDenise FosterGiuseppe FotiErwan FournRobert FowlerMarianne FraherDiego Franch-LlasatChristophe FraserJohn FraserMarcela Vieira FreireAna Freitas RibeiroCaren FriedrichRicardo FritzStéphanie FryNora FuentesMasahiro FukudaArgin GValérie GaborieauRostane GaciMassimo GagliardiJean-Charles GagnardAmandine Gagneux-BrunonSérgio GaiãoLinda Gail SkeiePhil GallagherElena Gallego CurtoCarrol GambleYasmin GaniArthur GaranRebekha GarciaJulia Garcia-DiazEsteban Garcia-GalloNavya GarimellaFederica GarofaloDenis GarotValérie GarraitNathalie GaultAisling GavinAnatoliy GavrylovAlexandre GaymardJohannes GebauerEva GeraudLouis Gerbaud MorlaesNuno GermanoPraveen Kumar GhisulalJade GhosnMarco GianiCarlo GiaquintoJess GibsonTristan GiganteMorgane GilgElaine GilroyGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanPetr GlybochkoEric GnallGeraldine GocoFrançois GoehringerSiri GoepelJean-Christophe GoffardJin Yi GohJonathan GolobRui GomesKyle GomezJoan Gómez-JunyentMarie GominetAlicia GonzalezPatricia GordonIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokMargarite GrableJeronimo GrafEdward Wilson GrandinPascal GranierGiacomo GrasselliChristopher GreenCourtney GreeneWilliam GreenhalfSegolène GreffeDomenico Luca GriecoMatthew GriffeeFiona GriffithsIoana GrigorasAlbert GroenendijkAnja Grosse LordemannHeidi GrunerYusing GuJérémie GuedjMartin GuegoDewi GuellecAnne-Marie GuerguerianDaniela GuerreiroRomain GueryAnne GuillaumotLaurent GuilleminaultMaisa Guimarães de CastroThomas GuimardMarieke HaalboomDaniel HaberHannah HabrakenAli HachemiNadir HadriSheeba HakakAdam HallMatthew HallSophie HalpinAnsley HamerRebecca HamidfarNaomi HammondTerese HammondLim Yuen HanRashan HaniffaKok Wei HaoHayley HardwickEwen HarrisonJanet HarrisonSamuel Bernard Ekow HarrisonAlan HartmanJunaid HashmiAilbhe HayesLeanne HaysJan HeermanLars HeggelundRoss HendryMartina HennessyAquiles Henriquez-TrujilloMaxime HentzienDiana HernandezJaime Hernandez-MontfortAndrew HersheyLiv HesstvedtAstarini HidayahDawn HigginsEibhlin HigginsRupert HigginsRita HinchionSamuel HintonHiroaki HiraiwaHaider HirkaniHikombo HitotoAntonia HoYi Bin HoAlexandre HoctinIsabelle HoffmannWei Han HohOscar HoitingRebecca HoltJan Cato HolterPeter HorbyJuan Pablo HorcajadaKoji HoshinoKota HoshinoIkram HouasCatherine HoughStuart HoulthamJimmy Ming-Yang HsuJean-Sébastien HulotStella HuoAbby HurdSamreen IjazM. Arfan IkramCarlos Cañada IllanaHajnal-Gabriela IllesPatrick ImbertHugo InácioCarmen Infante DominguezYun Sii IngElias IosifidisMariachiara IppolitoVera IrawanySarah IsgettTiago IsidoroNadiah IsmailMargaux IsnardJunji ItaiAsami ItoDaniel IvulichDanielle JaafarSalma JaafouraJulien JabotClare JacksonNina JamiesonVictoria JanesPierre JaquetWaasila JassatColine Jaud-FischerStéphane JaureguiberryJeffrey JavidfarDenise JaworskyFlorence JegoAnilawati Mat JelaniSynne JenumRuth Jimbo-SotomayorOng Yiaw JoeRuth GarcíaCédric JosephMark JosephSwosti JoshiMercé JourdainPhilippe JouvetAnna JungHanna JungDafsah JuzarOuifiya KafifFlorentia KaguelidouNeerusha KaisbainThavamany KaleesvranSabina KaliAlina KalicinskaSmaragdi KalomoiriMuhammad Aisar Ayadi KamaluddinZul Amali Che KamaruddinNadiah KamarudinDarshana Hewa KandambyChris KandelKong Yeow KangPratap KarpayahTodd KarsiesChristiana KartsonakiDaisuke KasugaiAnant KatariaKevin KatzAasmine KaurChristy KayHannah KeaneSeán KeatingPulak KediaAndrea KellyAoife KellyClaire KellyNiamh KellySadie KellyYvelynne KellyMaeve KelseyRyan KennedyKalynn KennonSommay KeomanyMaeve KernanYounes KerroumiSharma KeshavEvelyne KestelynImrana KhalidAntoine KhalilCoralie KhanIrfan KhanKrish KherajaniMichelle KhoDenisa KhooRyan KhooSaye KhooKhor How KiatYuri KidaPeter KiizaBeathe Kiland GranerudAnders Benjamin KildalJae Burm KimAntoine KimmounDetlef Kindgen-MillesAlexander KingNobuya KitamuraPaul KlenermanRob KlontGry Kloumann BekkenStephen KnightRobin KobbeChamira KodippilyMalte Kohns VasconcelosMamoru KomatsuIsaric Collaborator KortenCaroline KosgeiArsène KpangonKarolina KrawczykSudhir KrishnanVinothini KrishnanOksana KruglovaDeepali KumarGanesh KumarPavan Kumar VechamDinesh KuriakoseEthan KurtzmanNeurinda Permata KusumastutiDemetrios KutsogiannisGalyna KutsynaKonstantinos KyriakoulisRaph HamersMarie LachatreMarie LacosteJohn LaffeyNadhem LafhejMarie LagrangeFabrice LaineOlivier LairezMarc LambertFrançois LamontagneMarie Langelot-RichardVincent LangloisEka Yudha LantangMarina LanzaCédric LaouénanSamira LaribiDelphine LariviereStéphane LasrySakshi LathOdile LaunayDidier LaureillardYoan Lavie-BadieAndrew LawCassie LawrenceTeresa LawrenceMinh LeClément Le BihanCyril Le BrisGeorges Le FalherLucie Le FevreQuentin Le HingratMarion Le MaréchalSoizic Le MestreGwenaël Le MoalVincent Le MoingHervé Le NagardPaul Le TurnierEma LealMarta Leal SantosBiing Horng LeeHeng Gee LeeJames LeeJennifer LeeSu Hwan LeeTodd LeeYi Lin LeeGary LeemingBénédicte LefebvreLaurent LefebvreBenjamin LefèvreSylvie LegacJean-Daniel LelievreFrançois LelloucheAdrien LemaignenVéronique LemeeAnthony LemeurGretchen LemminkHa Sha LeneJenny LennonRafael LeónMarc LeoneMichela LeoneFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierAmy Lester-GrantAndrew LetiziaSophie LetrouBruno LevyYves LevyClaire Levy-MarchalKatarzyna LewandowskaErwan L'HerGianluigi Li BassiJanet LiangGeoffrey LiegeonKah Chuan LimWei Shen LimChantre LimaBruno LinaLim LinaAndreas LindMaja Katherine LingadGuillaume LingasSylvie Lion-DaolioSamantha LissauerKeibun LiuMarine LivrozetPatricia LizotteAntonio LoforteNavy LolongLeong Chee LoonDiogo LopesDalia Lopez-ColonJose Lopez-RevillaAnthony LoschnerPaul LoubetBouchra LouftiGuillame LouisSilvia LourencoLara Lovelace-MaconLee Lee LowMarije LowikJia Shyi LoyJean Christophe LucetCarlos LunaOlguta LunguLiem LuongNestor LuqueDominique LutonNilar LwinRuth LyonsOlavi MaasikasOryane MabialaMoïse MachadoSara MachadoGabriel MachedaHashmi MadihaGiuseppe MagliettaRafaël MahieuSophie MahyAna Raquel MaiaLars MaierMylène MailletThomas MaitreMaria MajoriMaximilian MalfertheinerNadia MalikPaddy MallonFernando MaltezDenis MalvyPatrizia MammiVictoria MandaJose MandeiLaurent MandelbrotFrank ManettaJulie MankikianEdmund ManningAldric ManuelDaniel MarinoFlávio MarinoSamuel MarkowiczAna MarquesCatherine MarquisBrian MarshMegan MarshalJohn MarshallCelina Turchi MartelliDori-Ann MartinEmily MartinGuillaume Martin-BlondelIgnacio Martin-LoechesMartin MartinotAlejandro Martín-QuirosF. Eduardo MartinezAna MartinsJoão MartinsNuno MartinsCaroline Martins RegoGennaro MartucciOlga MartynenkoEva Miranda MarwaliMarsilla MarzukieJuan Fernado Masa JimenezDavid MasloveSabina MasonBasri Mat NorMoshe MatanDaniel MathieuMathieu MatteiRomans MatulevicsLaurence MaulinMichael MaxwellJavier MaynarMayfong MayxayThierry MazzoniLisa Mc SweeneyPeter MccannyColin McarthurAine MccarthyAnne MccarthyColin MccloskeyRachael McconnochieSherry McdermottSarah McdonaldAine McelroySamuel McelweeVictoria MceneanyNatalie McevoyAllison McgeerChris MckayJohnny MckeownKenneth McleanPaul McnallyBairbre McnicholasElaine McpartlanEdel MeaneyCécile Mear-PassardMaggie MechlinOmar MehkriFerruccio MeleLuis MeloJoao Joao MendesOgechukwu MenkitiKusum MenonFrance MentréAlexander MentzerEmmanuelle MercierNoémie MercierAntoine MerckxMayka Mergeay-FabreBlake MerglerLaura MersonTiziana MeschiAntónio MesquitaRoberta MetaOsama MetwallyAgnès MeybeckDan MeyerAlison MeynertVanina MeysonnierAmina MezianeMehdi MezidiCéline MichelangleiIsabelle MicheletEfstathia MihelisVladislav MihnovitJennene MillerHugo Miranda-MaldonadoNor Arisah MisnanNik Nur Eliza MohamedTahira Jamal MohamedAsma MoinElena MolinosBrenda MolloyMary MoneAgostinho MonteiroClaudia MontesGiorgia MontrucchioSarah MooreShona MooreLina Morales CelyLucia MoroBen MortonCatherine MotherwayAna MotosHugo MouquetClara Mouton PerrotJulien MoyetCaroline MudaraNg Yong MuhDzawani MuhamadJimmy MullaertFredrik MüllerKarl Erik MüllerDaniel MunblitAisling MurphyLorna MurphyMarlène MurrisSrinivas MurthyHimed MusaabCarlotta MuttiHimasha MuvindiGugapriyaa MuyandyDimitra Melia MyrodiaFarah Nadia Mohd-HanafiahDave NagpalAlex NagrebetskyMangala NarasimhanNageswaran NarayananAlasdair Nazerali-MaitlandNadège NeantHolger NebCoca NecsoiNikita NekliudovErni NelwanRaul NetoEmily NeumannPauline Yeung NgAnthony NghiDuc NguyenOrna Ni ChoileainNiamh Ni LeathlobhairAlistair NicholPrompak NitayavardhanaStephanie NonasNurul Amani Mohd NoordinMarion NoretNurul Faten Izzati NorharizamLisa NormanAnita NorthAlessandra NotariMahdad NoursadeghiKarolina NowickaAdam NowinskiSaad NseirJose NunezNurnaningsih NurnaningsihDwi Utomo NusantaraElsa NyamankollyFionnuala BrienAnnmarie CallaghanAnnmarie O’callaghanGiovanna OcchipintiDerbrenn OconnorMax O’donnellTawnya OgstonTakayuki OguraTak-Hyuk OhSophie O’halloranKatie O’hearnShinichiro OhshimoAgnieszka OldakowskaJoão OliveiraLarissa OliveiraPiero OlliaroConar O’neilDavid OngJee Yan OngWilna OosthuyzenAnne OpavskyPeter OpenshawClaudia Milena Orozco-ChamorroJamel OrtolevaJavier OsatnikLinda O’sheaMiriam O’sullivanSiti Zubaidah OthmanNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesAmanda PalaciosMassimo PalmariniGiovanna PanarelloPrasan Kumar PandaLai Hui PangMauro PanigadaNathalie PansuAurélie PapadopoulosPaolo ParducciEdwin Fernando Paredes OñaRachael ParkeMelissa ParkerJérémie PasquierBruno PasteneFabian PataunerDrashti PatelMohan Dass PathmanathanLuís PatrãoPatricia PatricioJuliette PatrierLaura PatriziLisa PattersonChristelle PaulMical PaulJorge PaulosWilliam PaxtonJean-François PayenSandra PeakeKalaiarasu PeariasamyGiles PeekFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezLuis PerielThomas PerpointAntonio PesentiVincent PestreLenka PetrouMichele PetrovicVentzislava Petrov-SanchezFrank Olav PettersenGilles PeytavinScott PharandOoyanong PhonemixaySoulichanya PhoutthavongMichael PiagnerelliWalter PicardOlivier PiconeMaria de PieroCarola PierobonDjura PiersmaCarlos PimentelRaquel PintoValentine PiquardCatarina PiresIsabelle PironneauLionel PirothRoberta PisiAyodhia PitalokaChiara PiubelliRiinu PiusLaurent PlantierHon Shen PngJulien PoissyRyadh PokeerbuxMaria Pokorska-SpiewakSergio PoliGeorgios PollakisDiane PonscarmeJolanta PopielskaDiego Bastos PortoAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaViladeth PraphasiriSébastien PreauChristian PrebensenJean-Charles PreiserAnton PrinssenMark PritchardGamage Dona Dilanthi PriyadarshaniLucia ProençaSravya PudotaOriane PuéchalBambang Pujo SemediMatteo PuntoniGregory PurcellLuisa QuesadaVilmaris Quinones-CardonaElse Quist-PaulsenMohammed QuraishiMaia RabaaChristian RabaudAldo RafaelMarie RafiqGabrielle RagazzoMutia RahardjaniAhmad Kashfi Haji Ab RahmanRozanah Abd RahmanFernando RainieriGiri Shan RajahramNagarajan RamakrishnanJosé RamalhoAhmad Afiq RamliBlandine RammaertGrazielle Viana RamosAnais RampelloRajavardhan RangappaRitika RanjanElena RanzaChristophe RappAasiyah RashanThalha RashanMenaldi RasminIndrek RätsepCornelius RauFrancesco RausaTharmini RaviAndre RealStanislas RebaudetSarah RedlBrenda ReeveLiadain ReidDag Henrik ReikvamRenato ReisJordi RelloJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaLuis Felipe ReyesTiago ReyesMaria Ines RibeiroAntonia RicchiutoDavid RichardsonDenise RichardsonLaurent RichierSiti Nurul Atikah Ahmad RidzuanJordi RieraAna RiosAsgar RishuPatrick RispalKarine RissoMaria Angelica Rivera NuñezNicholas RizerChiara RobbaAndré RobertoDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaJulia Rodriguez AbreuBernhard RoesslerClaire RogerPierre-Marie RogerEmmanuel RoilidesAmanda RojekJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerAndrea RossaneseMatteo RossettiSandra RossiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaeve RyanMaria RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaLuca SacchelliMusharaf SadatValla SahraeiNadia SaidaniMaximilien Saint-GillesPranya SakiyalakLeonardo SalazarGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorOlivier SanchezAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineOana SandulescuMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroIam Claire E. SarmientoBenjamine SartonAnkana SatyaSree SatyapriyaRumaisah SatyawatiEgle SaviciuteParthena SavvidouYen Tsen SawJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderStephan SchrollMichael SchwameisGary SchwartzBrendan SciclunaJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzMageswari SelvarajooCaroline SemailleMalcolm SempleRasidah Bt SenianEric SennevilleClaudia SepulvedaFilipa SequeiraTânia SequeiraAry Serpa NetoEllen ShadowitzSyamin Asyraf ShahidanMohammad ShamsahAnuraj ShankarShaikh SharjeelPratima SharmaCatherine ShawVictoria ShawRajesh Mohan ShettyRohan ShettyHaixia ShiNisreen ShibanMohiuddin ShiekhTakuya ShigaNobuaki ShimeHiroaki ShimizuKeiki ShimizuSally ShrapnelHoi Ping ShumNassima Si MohammedNg Yong SiangJeanne SibiudeBountoy SibounheuangAtif SiddiquiLouise SigfridPiret SillaotsCatarina SilvaMaria Joao SilvaRogério SilvaBenedict Sim Lim HengWai Ching SinDario SinattiBudha Charan SinghPunam SinghPompini Agustina SitompulKarisha SivamVegard SkogenSue SmithBenjamin SmoodCoilin SmythMichelle SmythMorgane SnackenDominic SoTze Vee SohJoshua SolomonTom SolomonEmily SomersAgnès SommetMyung Jin SongRima SongTae SongJack Song ChiaMichael SonntagbauerAzlan Mat SoomAlbert SottoEdouard SoumAna Chora SousaMarta SousaMaria Sousa UvaVicente Souza-DantasAlexandra SperryElisabetta SpinuzzaB. DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartRicha SuDecy SubektiGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováAtie SuwartiAndrey SvistunovSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziFabio TacconeLysa TaghersetShahdattul Mawarni TaibEwa TalarekSara TalebJelmer TalsmaRenaud TamisierMaria Lawrensia TampubolonKim Keat TanLe Van TanYan Chyi TanClarice TanakaHiroyuki TanakaTaku TanakaHayato TaniguchiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikRichard TedderTze Yuan TeeJoão TeixeiraSofia TejadaMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitZhang Duan ThamSuvintheran ThangaveluV. ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonDavid ThomsonEmma ThomsonSurain Raaj Thanga ThuraiDuong Bich ThuyRyan ThwaitesAndrea TicinesiPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitNoémie TissotJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiMarta TorreAntoni TorresMargarida TorresRosario Maria Torres Santos-OlmoHernando Torres-ZevallosMichael TowersTony TrapaniHuynh Trung TrieuThéo TriouxCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteAlexis TurgeonJean-Marie TurmelLance TurtleAnders TveitaPawel TwardowskiMakoto UchiyamaPg Ishara UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsPiero ValentiniLuís Val-FloresAmélie ValranIlaria ValzanoStijn Van de VeldeMarcel van Den BergeMachteld van Der FeltzJob van Der PalenPaul van Der ValkNicky van Der VekensPeter van Der VoortSylvie van Der WerfLaura Van GulikJarne Van HattemCarolien Van NettenFrank van Someren GreveGitte Van TwillertIlonka Van VeenHugo Van WilligenNoémie VanelHenk VanoverscheldePooja VargheseMichael VarroneShoban Raj VasudayanCharline VauchyShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoNguyen van Vinh ChauGayatri VishwanathanBenoit VisseauxHannah VisserChiara VitielloManivanh VongsouvathHarald VonkemanFanny VuottoNoor Hidayu WahabSuhaila Abdul WahabNadirah Abdul WahidMarina WainsteinSteve WebbJia WeiKatharina WeilTan Pei WenSanne WesseliusT. Eoin WestMurray WhamBryan WhelanPaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSue WillemsPatricia WilliamsVirginie WilliamsEvert-Jan WilsNg Wing YiuCalvin WongTeck Fung WongXin Ci WongYew Sing WongNatalie WrightGan Ee XianLim Saio XianKuan Pei XuanIoannis XynogalasSophie YacoubSiti Rohani Binti Mohd YakopMasaki YamazakiElizabeth YaradYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichTouxiong YiayeToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeGustavo ZabertKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : University of Oxford University of Oxford University of Oxford University of Oxford University of Oxford Human genetics of infectious diseases: Complex predisposition French COVID cohort study group Department of Mathematics and Statistics Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes Hypoxie et PhysioPathologie Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN régulateurs bactériens et médecine Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail
• Publié dans Scientific Reports le 26/10/2020

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Résumé : By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients.

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Fichiers liés : s41598-024-63212-7-2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/07/2024
• Auteurs : Patrick BogdanowiczPaul BensadounMaïté NoizetBenoît BégantonArmony PhilippeSandrine Alvarez-GeorgesGautier DoatAmélie TouretteSandrine Bessou-TouyaJean-Marc LemaitreHélène Duplan
• Organismes : Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Laboratoires dermatologiques Avène Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Laboratoire de Pharmacochimie Pierre Fabre Dermo-Cosmétique
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) that includes MMPs, CXCLs and S100A8/9. Reducing the SASP with senotherapeutics is a promising strategy to reduce skin aging. Here we evaluated the effect of a formula containing niacinamide and hyaluronic acid, which are known to limit senescence and skin aging. We conducted three different studies. (1) Ex vivo explants treated with the formula had more collagen and glycosaminoglycan. (2) In a clinical trial with forty-four women, two months of treatment improved fine lines, wrinkles, luminosity, smoothness, homogeneity, and plumpness. (3) In a third study on thirty women, we treated one arm for two months and took skin biopsies to study gene expression. 101 mRNAs and 13 miRNAs were differentially expressed. We observed a likely senomorphic effect, as there was a decrease in many SASP genes including MMP12 and CXCL9 and a significant downregulation of autocrine signaling genes: S100A8 and S100A9. These pharmaco-clinical results are the first to demonstrate the senomorphic properties of an effective anti-aging formula in skin.

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Fichiers liés : s41598-024-66624-7.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/07/2024
• Auteurs : Alice MathieuJean ReignierAmélie Le GougeGaetan PlantefeveJean-Paul MiraLaurent ArgaudPierre AsfarJulio BadieNicolae-Vlad BotocHoang-Nam BuiDelphine ChatellierLouis ChauvelotChristophe CraccoMichael DarmonAgathe DelboveJérôme DevaquetLouis-Marie DumontOlivier GontierSamuel GroyerYannick HourmantSamir JaberFabien LambiotteBenjamin MadeuxJulien MaizelOlivier MartinetVirginie MaximeEmmanuelle MercierMai-Anh NaySaad NseirGael PitonJean-Pierre QuenotAnne RenaultJean-Philippe RigaudFrancis SchneiderMichel SirodotBertrand SouweineFabienne TamionDidier ThéveninNathalie Thieulot-RolinFrançois TinturierPatrice TirotIsabelle VinatierChristophe VinsonneauJean-Baptiste LascarrouAlexandra Laurent
• Organismes : Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] Université Bourgogne Europe Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Hôpital Cochin [AP-HP] Université Paris Cité Hôpital Edouard Herriot [CHU - HCL] Centre Hospitalier Universitaire d'Angers Hôpital Nord Franche-Comté [Hôpital de Trévenans] CH de Saint-Malo [Broussais] Centre Hospitalier Universitaire de Bordeaux Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital de la Croix-Rousse [CHU - HCL] Centre Hospitalier d'Angoulême Hopital Saint-Louis [AP-HP] Université Paris Cité Centre hospitalier Bretagne Atlantique (Morbihan) Hôpital Foch [Suresnes] Hôpital Louis Mourier - AP-HP [Colombes] Hôpitaux de Chartres [Chartres] Centre hospitalier de Montauban Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Hôpital Saint Eloi [CHU Montpellier] Centre hospitalier [Valenciennes, Nord] Centre Hospitalier de Bigorre [Tarbes] CHU Amiens-Picardie Médecine Intensive-Réanimation [CHU Amiens] Centre Hospitalier Universitaire de La Réunion Infection et inflammation Hôpital Raymond Poincaré [AP-HP] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Regional d'Orléans Centre Hospitalier Régional Universitaire [CHU Lille] Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Centre Hospitalier Régional Universitaire de Besançon Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Lipides et transfert des lipides dans l'inflammation et le sepsis (CTM UMR 1231) Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Hôpital de la Cavale Blanche - CHRU Brest Centre hospitalier de Dieppe Hôpitaux Universitaires de Strasbourg Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] CHU Gabriel Montpied [Clermont-Ferrand] Hôpital Charles Nicolle [Rouen] Endothélium, valvulopathies et insuffisance cardiaque Centre Hospitalier de Lens Groupe Hospitalier Sud Ile-de-France CHU Amiens-Picardie Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier de Béthune Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Laboratoire de psychologie : dynamiques relationnelles et processus identitaires [Dijon] CHU Dijon
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience. Methods This prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ). Results Of the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience ( p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008–1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950–0.996; p = 0.02). Conclusions Resilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.

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Fichiers liés : 2024 Mathieu et al., Resilience after severe critical illness.pdf

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• Type de publi. :
• Date de publi. : 10/07/2024
• Auteurs : Romain DavidErwan LemesleJuline AuverlotLaetitia BariatHervé VaucheretJulio Saez-VasquezJean-Philippe Reichheld
• Organismes : Laboratoire Génome et développement des plantes Laboratoire Génome et développement des plantes Laboratoire Génome et développement des plantes Laboratoire Génome et développement des plantes Institut Jean-Pierre Bourgin Laboratoire Génome et développement des plantes Laboratoire Génome et développement des plantes

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Résumé : Plants are sessile organisms confronted to biotic or abiotic constraints. One of the main cellular response to stresses is modification of the redox homeostasis, which can induce signaling response pathways, for example by altering the redox status of thiol residues in proteins. In eukaryotic cells, small RNAs (siRNAs and miRNAs) are major regulators of gene expression, involved in most developmental and stress-response processes. Their biogenesis is mediated by RNaseIII endonuclease enzymes called DICER-LIKE (DCL) and RNASE THREE-LIKE (RTL), which mature almost all classes of double-stranded RNA precursors. In Arabidopsis thaliana, it has been shown that the RNA cleavage activity of the RTL1 isoform depends on the oxidation state of a specific cysteine (C230) located in its RNA binding domain (RBD). To better understand the role of cysteines on RTL1 activity, we have constructed Cys substitution versions of RTL1 preventing or mimicking oxidation. These versions have been tested biochemically for their RNA binding activities. MicroScale thermophoresis (MST) assays show that the Kd of RTL1 with mutated catalytic site (RTL1-cat) is in the nM range (260-670). In contrast, deletion of the RBD or mutation of the C230 (in S230), increases the Kd of RTL1-cat to the µM range (2-5). Thus, MST assays suggest that C230 may contribute to the stabilization of RTL1-RNA binding interactions and then facilitate RNA cleavage activity. In parallel, we have evaluated the contribution of RTL1 cys-oxidation to IR-PTGS triggered by overexpressing Cys substitution versions of RTL1 in the context of the JAP3 construct expressing PDS dsRNA under the control of the phloem-specific SUC2 promoter.

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• Type de publi. : Rapport
• Date de publi. : 09/07/2024
• Auteurs : Georges de SousaOlivier AdamAlain AymardJean-Christophe CahuzacEmilie BarrangerJean-Marc BerjeaudSylvie ChevalierGwenaël CorbelPierre GrevePhilippe HartemannClaire HellioDominique Hurtaud - PesselChristophe SoumetFarida OuadiYann MaximilienIsabelle Attig
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Laboratoire Images, Signaux et Systèmes Intelligents Ministère de l'économie et des finances Ministère des armées – Ministère de la défense [France] (1946-....) Université de Poitiers = University of Poitiers Université de Rouen Normandie Centre National de la Recherche Scientifique Écologie, Évolution, Symbiose [Équipe du laboratoire EBI Poitiers] Laboratoire des Sciences de l'Environnement Marin (LEMAR) Laboratoire de Fougères - ANSES Laboratoire de Fougères - ANSES Direction de l'évaluation des produits réglementés Direction de l'évaluation des produits réglementés Direction de l'évaluation des produits réglementés

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Résumé : L’institut technologique Forêt Cellulose Bois-Construction Ameublement (FCBA) a adressé le 20 novembre 2023 à la DGPR, une demande de dérogation 180 jours au titre de l’article 55, paragraphe 1 du règlement (UE) n°528/2012 pour l’utilisation du produit biocide « Termidor SC », un insecticide utilisé pour lutter contre les termites. Le produit Termidor SC contient la substance active fipronil (CAS : 120068-37-3) et il disposait d’une autorisation de mise à disposition sur le marché (AMM) jusqu’au 30 septembre 2023. Par décision du 29 septembre 2023, l’Anses a retiré l’autorisation de mise sur le marché du produit Termidor SC à compter du 30 septembre 2023 car l’approbation de la substance active fipronil expirait à compter de cette date et aucun dossier de demande de renouvellement de l’approbation de cette substance n’avait été déposé. Ce produit était utilisé depuis plusieurs années en tant que barrière chimique post-construction pour bloquer les remontées des termites depuis le sol vers le bâti. Selon l’institut technologique FCBA, il s’agissait du seul produit certifié CTB-P+ , sous AMM, qui avait démontré son efficacité sur l’ensemble des genres de termites présents en métropole et dans les DROM en tant que barrière chimique. Il existe également une deuxième technique de lutte contre les termites, la technologie piège-appât biocide. D’après les éléments transmis dans la demande de dérogation, celle-ci semble peu utilisée dans certains DROM et ne serait pas efficace sur tous les genres de termites et serait peu adaptée à certaines configurations de chantiers en métropole. Ainsi, la DGPR souhaite recueillir l’avis de l’Anses sur les questions suivantes : 1)Existe-t-il des alternatives autorisées en France ou dans d’autres pays de l’Union européenne au produit Termidor SC, et plus généralement aux produits à base de fipronil dans la lutte contre les termites (Reticulitermes sp. pour la Métropole ; Coptotermes sp. et Prorhinotermes sp. pour la zone Océan Indien ; Coptotermes sp., Nasutitermes sp. et Heterotermes sp. pour la zone Antilles), en traitement préventif/curatif des bâtiments existants? 2)Les technologies de lutte de type piège-appât sont-elles adaptées au contexte des DROM ? 3)La lutte contre les termites peut-elle reposer uniquement sur ces dernières ou nécessite-t-elle une complémentarité avec les méthodes reposant sur des barrières chimiques ?

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