Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Hélios BertinJean-Philippe PerrinPierre Corre
• Organismes : Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Service de Chirurgie maxillo-faciale et stomatologie Service de Chirurgie maxillo-faciale et stomatologie Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Regenerative Medicine and Skeleton
• Publié dans Orthodontie Française le 02/11/2020

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Résumé : Introduction L’objectif de cet article est de présenter l’approche diagnostique et thérapeutique des insuffisances verticales postérieures unilatérales. Matériel et méthodes Les auteurs exposent le protocole de prise en charge. Résultats L’insuffisance verticale postérieure (IVP) unilatérale se manifeste cliniquement par une obliquité du plan d’occlusion maxillo-mandibulaire et de la ligne bicommissurale, et par une déviation du menton. Radiographiquement, l’IVP se manifeste par une élévation de l’angle mandibulaire par rapport à la base de l’odontoïde. Parmi les étiologies, les atteintes congénitales sont les plus fréquentes et sont dominées par les hypocondylies. Les atteintes des premier et deuxième arcs branchiaux s’accompagnent, le plus souvent, de malformations associées des tissus mous, tandis que les atteintes acquises (post-traumatiques, ankyloses et atteintes rhumatismales) sont plus rares. La prise en charge nécessite une étroite collaboration orthodontico-chirurgicale et fait appel à des procédures non conventionnelles de chirurgie orthognathique. Trois techniques sont détaillées ainsi que leurs résultats attendus : la greffe chondro-costale, l’allongement vertical rétro-spigien selon la technique de Caldwell-Letterman et l’ostéotomie supra-basilaire intra-orale. Discussion Si la présentation clinique peut être fruste chez l’enfant, l’asymétrie faciale se majore le plus souvent au cours de la croissance pubertaire. Une prise en charge précoce en orthopédie dento-faciale peut parfois permettre de restaurer la croissance. Dans les autres cas, la collaboration entre l’orthodontiste et le chirurgien est plus que jamais nécessaire pour corriger l’asymétrie, parfois à l’aide de techniques chirurgicales non conventionnelles.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Romain BoulestreauAurélien LorthioirHervé DreauAlexandre PersuAntoine CremerPierre-Louis TharauxSébastien RubinBenjamin MaierMikael MazighiAlice SerisMichel PaquesSophie BonninJean Michel HalimiStéphane DebeugnyPhilippe Gosse
• Organismes : Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
• Publié dans Journal of Hypertension le 23/10/2020

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Résumé : Malignant hypertension has not disappeared and remains the most severe form of hypertension. More than 100 years after its description, many points remain unanswered. Mechanisms, definitions, and optimal treatment are still controversial. In 2019, we decided to launch a prospective multicentre multidisciplinary cohort in France to try to fill these gaps. This study aimed to describe the baseline characteristics of the first 302 included patients and compared these data to already published cohorts. We included patients with severe hypertension associated with severe hypertensive retinopathy and patients filling the HYP MOD (HYPertension MultiOrgan Damage) definition from a broad range of departments (cardiology, nephrology, neurology intensive care unit, emergency department, internal medicine). We collected clinical, biological, imaging, and target organ damage data at admission, along with social and demographic data. We also recorded diagnostic and therapeutic management, adverse events during hospitalization, and characteristics at discharge. We enrolled 302 patients in 32 months (105/year) among 40 centres and different specialties. They mainly included young men (68%, mean age 48.7 ± 14.5 years). Target organ damage involved the eye in 86.7% of patients, kidney in 58.6%, heart in 50%, brain in 32.8%, and Thrombotic Microangiopathy stigmata in 15.6%. Patients with severe retinopathy shared characteristics similar to those included in the most important cohorts already published. We also reported several additional subgroups of interest: one-third of our patients were less than 40 years old, one-third were of non-European origin, 14.3% were included through the multiorgan damage definition, without fundus severe injuries, 22.8% were treated without the use of IV therapy, 40.9% had normal or low renin level, and almost all patients were not on antihypertensive therapy at the time of the enrolment. These preliminary findings already challenge long-standing dogma, raise numerous questions, and provide a solid basis to address them in ancillary studies of the cohort.

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• Type de publi. : Autre publication
• Date de publi. : 01/12/2024
• Auteurs : Fabien ChardonPhilippe GuercheSophie Jasinski
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : Objective The primary aim of this collection is to identify the main genetic and physiological factors that guide the accumulation of reserves, particularly in the form of lipids or proteins, in Arabidopsis thaliana. Arabidopsis serves as a valuable model for understanding reserve accumulation in European oilseeds. This dataset collection can also be used to explore the genetic and physiological factors guiding seed composition in Arabidopsis, with potential applications in comparative genetics, environmental response studies, and functional genomics. Archive 1 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration, all estimated using NIRS. Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines (RILs) from four populations: Bla-1×Col-0, Tsu-0×Col-0, Ct-1×Col-0, and Cvi-0×Col-0. Natural Accessions: Includes 49 natural accessions of Arabidopsis thaliana. Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 2 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines from eight populations: Bla-1×Col-0, Tsu-0×Col-0, Ct-1×Col-0, Cvi-0×Col-0, Shahdara×Col-0, Ge-0×Col-0, Bur-0×Col-0, and Blh-1×Col-0. Natural Accessions: Includes 49 natural accessions of Arabidopsis thaliana. Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 4 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Plant Flowering Time, Thousand Seed Weight. Populations Studied: 20 recombinant inbred lines from eight populations (same as Archive 2). Natural Accessions: 49 natural accessions, plus 2 mutants (pkp2-1, tag1-2, wri1-3). Replicates: Data collected in three replicates per line or accession. Growth Conditions: Plants were grown in growth chamber. Archive 5 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Additional Traits: Thousand Seed Weight. Populations Studied: Around 160 inbred lines from three recombinant inbred line populations: Ct-1×Col-0, Cvi-0×Col-0, and Bur-0×Col-0. Replicates: Data collected in three replicates per line. Growth Conditions: Plants were grown in greenhouses. Reference: Data corresponds to the material used in the study by Chardon et al. (2014). Archive 6 Seed Composition: Lipid percentage, Protein percentage, Galactose percentage, Nitrogen concentration, and Carbon concentration (NIRS). Populations Studied: 324 natural Swedish accessions of Arabidopsis thaliana. Replicates: Data collected in four replicates per accession. Growth Conditions: Plants were grown in growth chambers.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Guillermo A AlanisPierre BoutouyrieMouad AbouqatebRosa Maria BrunoRachel E ClimieThomas van SlotenNicolas DanchinBruno PannierStéphane LaurentXavier JouvenJean‐philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire University of Tasmania [Hobart] Paris-Centre de Recherche Cardiovasculaire University Medical Center [Utrecht] Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire University of Tasmania [Hobart]
• Publié dans American Journal of Preventive Cardiology le 09/04/2025

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Résumé : Objective: To investigate the association between joint manifestations of vascular ageing (VA) and hypertension. Methods: We used baseline (2008-2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment). VA manifestations were assessed at baseline via echo-tracking in the right common carotid artery. Clustering analysis identified patterns of VA and their association with hypertension was assessed with logistic regression. Results: The cross-sectional analysis included 9,096 participants (mean age: 59±6 years, 39% female). Hypertension prevalence was 36% (n=3,276). Three clusters of VA manifestations were identified. Cluster 1 (n=4,326;47.6%) was characterized by healthy vascular ageing (HVA), Cluster 2 by increased arteriosclerosis (ART) (n=2,274;25.0%) and Cluster 3 by greater atherosclerosis prevalence (ATH) (n=2,496;27.4%). Compared to the HVA cluster, ART (aOR 3.94; 95% CI 3.50;4.45) and ATH clusters (aOR 2.69; 95% CI 2.38;3.04) were associated with prevalent hypertension. The prospective analysis included 5,310 normotensives with 754 (14.1%) cases of incident hypertension (median follow-up of 10.05 years [range: 10.00;10.15]). Both ART (aOR 1.34; 95% CI 1.08;1.65) and ATH (aOR 1.70; 95% CI 1.40;2.07) clusters were associated with incident hypertension. Conclusion: Vascular ageing manifestations reflecting increased carotid arteriosclerosis and atherosclerosis are related to prevalent and incident hypertension.

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Fichiers liés : AJPC Alanis et al - Hypertension paper.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/12/2024
• Auteurs : Isabelle ArpinFrancois SarrazinGuillaume BalNolwenn Drouet-HoguetRichard DumezLoan PichonAlice RegnierGaspard RenaultCécile BarnaudSarah BauduinCarmen Bessa-GomesPhilippe BilletChristine Breitenmoser-WürstenChristophe DuchampOlivier GimenezRaphaël MathevetCoralie MounetAlexandre RobertJean-Michel VandelJuliette YoungFridolin Zimmermann
• Organismes : Laboratoire des EcoSystèmes et des Sociétés en Montagne Conservation des espèces, Restauration et Suivi des Populations Centre d'Ecologie et des Sciences de la COnservation Muséum national d'Histoire naturelle Patrimoine naturel Service conservation et gestion des espèces à enjeux Muséum national d'Histoire naturelle ENVOLIS Muséum national d'Histoire naturelle Éco-Anthropologie Laboratoire d'Anthropologie des Enjeux Contemporains Dynamiques et écologie des paysages agriforestiers Service conservation et gestion des espèces à enjeux Ecologie, Société et Evolution (ex-Ecologie, Systématique et Evolution) Université Jean Moulin Lyon 3 - Faculté de Droit Projets de gestion coordonnés pour la protection et la gestion des carnivores en Suisse Service conservation et gestion des espèces à enjeux Centre d’Ecologie Fonctionnelle et Evolutive Centre d’Ecologie Fonctionnelle et Evolutive Pacte, Laboratoire de sciences sociales Muséum national d'Histoire naturelle Service conservation et gestion des espèces à enjeux Agroécologie [Dijon] Projets de gestion coordonnés pour la protection et la gestion des carnivores en Suisse

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Résumé : Le 18 mars 2022, Mme Barbara Pompili, ministre de la Transition écologique, et Mme Bérangère Abba, secrétaire d’État chargée de la biodiversité, ont saisi conjointement le Muséum national d’Histoire naturelle (MNHN) et l’Office français de la biodiversité (OFB) pour la réalisation d’une expertise scientifique collective et technique (ci-après l’ESCO) visant à définir les « conditions de viabilité à terme » du lynx boréal (Lynx lynx) en France ainsi que d’une étude sur « les conditions de réussite (techniques, réglementaires, sociétales) préalables à la décision de recours à une opération de renforcement de population » (ci-après l’Étude). À leur demande, l’ESCO et l’Étude s’appuient sur des approches complémentaires en écologie et en sciences humaines et sociales.

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Fichiers liés : MNHN_OFB_Lynx_Boreal_Expertise_Resume_1224v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Léna SleimanCédric DananchéSophie GardesIsabelle FredenucciCamille DuvalIsabelle DurieuFabien ZoulimPhilippe VanhemsPierre CassierChristelle Elias
• Organismes : Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Pôle de Santé Publique [Lyon] Hospices Civils de Lyon Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Hospices Civils de Lyon Nantes Université - UFR de Médecine et des Techniques Médicales Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Hospices Civils de Lyon Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon
• Publié dans Infectious Diseases Now le 08/09/2022

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Mathilde AmiotLaurent MortierStéphane DalleOlivier DereureSophie DalacCaroline DutriauxMarie-Thérèse LecciaEve MaubecJean-Philippe ArnaultFlorence Brunet-PossentiJulie de QuatrebarbesFlorence Granel-BrocardCaroline Gaudy-MarquesteCecile PagesPierre-Emmanuel StoebnerPhilippe SaiagThierry LesimpleDelphine LegoupilAlain DupuyHenri MontaudiéBastien OrianoCéleste LebbéRaphaël Porcher
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Methods of therapeutic evaluation of chronic diseases | Méthodes de l’évaluation thérapeutique des maladies chroniques Centre d'épidémiologie Clinique [Hôtel-Dieu]
• Publié dans EClinicalMedicine le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Nathalia da Silva Rodrigues MendesRenato Rodrigues SilvaMoïse Kombolo-NgahPierre-Philippe RivetJerôme TondussonTatianne Ferreira de OliveiraSghaier ChrikiMarie-Pierre Ellies-OuryJean-François Hocquette
• Organismes : Unité Mixte de Recherche sur les Herbivores - UMR 1213 Universidade Federal de Goiás [Goiânia] ISARA Unité Mixte de Recherche sur les Herbivores - UMR 1213 Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Unité Mixte de Recherche sur les Herbivores - UMR 1213 Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine Unité Mixte de Recherche sur les Herbivores - UMR 1213
• Publié dans Veterinary and Animal Science le 29/10/2020

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Résumé : We hypothesized that transportation might impact beef sensory quality, particularly as the distance between farms and the slaughterhouse increases. Specifically, we expected that pre-slaughter transport over longer distances would induce stress in the cattle, resulting in elevated ultimate pH and, consequently, reduced beef quality. Thus, this study aimed to specifically study the effects of transport in commercial conditions of Limousin cows from farms located in different areas of France to slaughter on ultimate pH (pHu) measured in the Longissimus thoracis muscle (LT), marbling (two major factors affecting eating quality) and the MSA Index (a global indicator of potential eating quality at the carcass level). Cattle were studied according to distance (<50 km; between 50 and 150 km; and between 150 and 250 km from the slaughterhouse) and according to transport time from the farm to the slaughterhouse (divided into short, moderate, and extended). We found that neither distance nor transport time significantly affected pHu of beef and the other studied parameters (cold carcass weight, meat color, MSA Marbling and MSA Index). Consequently, in our commercial conditions, we concluded that the effects of transport on beef carcasses and beef eating quality of Limousin cows are negligible.

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Fichiers liés : 2024_ Da Silva Rodrigues Mendes_Vet_Anim_Sci.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Maxime de GuillebonRodrigue GarciaStéphane DebeugnyHugues BaderVincent ProbstNicolas BidegainKumar NarayananJacques MansouratiAymeric MenetPierre OllitraultChristelle MarquiéBenoît Guy-MoyatPierre MondolyPhilippe ChevalierNicolas BadencoNathalie BeharLaurence Jesel-MorelBertrand PierreNicolas LelloucheJean-Claude DeharoPeggy JaconFrédéric AnselmeSerge BovedaEloi Marijon
• Organismes : Centre hospitalier de Pau Service de cardiologie [CHU de Poitiers] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre hospitalier de Pau Centre hospitalier de Pau Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Université catholique de Lille Hôpital Saint Philibert [Lomme] Université de Caen Normandie - UFR Santé Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Université de Limoges CHU Limoges Service Cardiologie [CHU Toulouse] Hôpital Louis Pradel [CHU - HCL] Université Claude Bernard Lyon 1 CHU Pitié-Salpêtrière [AP-HP] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nanomédecine Régénérative Centre de Recherche en Biomédecine de Strasbourg Nouvel Hôpital Civil de Strasbourg Centre Hospitalier Régional Universitaire de Tours CHU Henri Mondor [Créteil] Hôpital de la Timone [CHU - APHM] Aix Marseille Université Centre Hospitalier Alpes Isère [Grenoble, France] CHU Rouen Clinique Pasteur [Toulouse] Hôpital Européen Georges Pompidou [APHP]
• Publié dans Heart Rhythm le 26/10/2020

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Résumé : Background: Electrocardiographic screening before subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation is unsuccessful in around 10% of cases. A personalized screening method, by slightly moving the electrodes, to obtain a better R/T ratio has been described to overcome traditional screening failure. Objective: The objectives of the SIS study were to assess to what extent a personalized screening method improves eligibility for S-ICD implantation and to evaluate the inappropriate shock rate after such screening success. Methods: All consecutive patients eligible for an S-ICD implantation were prospectively recruited across 20 French centers between December 2019 and January 2022. In case of traditional screening failure, patients received a second personalized screening. If at least 1 vector was positive, the personalized screening was considered successful, and the patient was eligible for implantation. Results: The study included 474 patients (mean age, 50.4 ± 14.1 years; 77.4% men). Traditional screening was successful in 456 (96.2%) cases. This figure rose to 98.3% (n = 466; P = .002) when personalized screening was performed. All patients implanted after successful personalized screening had correct signal detection on initial device interrogation. Nevertheless, after 1-year follow-up, 3 of the 7 patients (43%) implanted with personalized screening experienced inappropriate shock vs 18 of the 427 patients (4.2%) with traditional screening and S-ICD implantation (P = .003). Conclusion: Traditional S-ICD screening was successful in our study in a high proportion of patients. Considering the small improvement in success of screening and a higher rate of inappropriate shock, a strategy of personalized screening cannot be routinely recommended. Clinicaltrials: gov identifier: NCT04101253

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Fichiers liés : de Guillebon et al. - 2024 - Personalized Screening Before Subcutaneous Cardiov.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2024
• Auteurs : Hélène SarterThibaut CrétinGuillaume SavoyeMathurin FumeryAriane LeroyerLuc DauchetThierry PaupardHugues CoevoetPauline WilsNicolas RichardDominique TurckDelphine LeyCorinne Gower-RousseauEric AgouteNajib Al GhossainiRaied Al HameediMyriam Al KhatibSaria Al TurkJean-Marie AndreMatthieu AntoineMichel AntoniettiAmar AouakliLaura Armengol-DebeirIbrahim AroichaneFadi AssiEric AuxenfantsAlina AvramKassem AzzouziDamyan BankovskiBernard BarbryNicolas BardouxPhilippe BaronAnne BaudetPauline BayartBrice BazinArash BebahaniJean-Pierre BecqwortHoussem Ben AliEmmanuel Ben SoussanCoralie BenardVincent BenetCorinne BenguiguiAbdeslam BentalSara Bentaleb-BellatiIsabelle BerkelmansJacques BernetKarine BernouNathalie Bertiaux-VandaelePauline BertotValérie BertrandEmilie BiloudNathalie BironBenjamin BismuthCyril BlanchardMaurice BleuezFabienne BlondelValérie BlondinMarius BobulaPhilippe BohontEléonore BoivinVanessa Bon DjemahEric BonifacePhilippe BonnierePierre BonvarletArnaud BoruchowiczRaoul BostvironnoisMédina BoualitAhlem BouazzaBruno BoucheChristian BoudaillerClaude BourgeauxMorgane Bourgeois-FumeryArnaud BourguetAgnès BourienneHamza BoutalebAlexis BouthorsJulien BrancheFranck BrazierMarie BridenneHélène BrihierLaura BrilPhilippe BuloisPierre BurgiereJoël ButelJean-Yves CanvaValérie Canva-DelcambreFlorence CardotSandrine CarettePierre CarpentierMichel CassagnouJean-François CassarFrançois CastexPascale CatalaStéphane CattanSylviane CatteauBernard CaujolleGérard CayronCatherine ChandelierCloé CharpentierMarthe Chavance-TheluAgathe ChenyDinu ChiritaAntoine ChoteauJean-François ClaerboutPierre-Yves ClergueHugues CoevoetGil CohenMarie ColinRégis ColletJean-Frédéric ColombelStéphanie CoopmanLucie CordiezAntoine CortotJean CorvisartFrédéric CouttenierJean-François CrinquetteValérie CrombeAbdelhakim DaoudiVincent DapvrilThierry DavionSébastien DecosterLaurent DefontaineNicolas DegraveAurélien DejaegerRichard DelcenserieMarine DeleplanqueDorothée DelesalleOlivier DeletteThierry DelgrangeLaurence DelhoustalJean-Stéphane DelmotteSabri DemmaneGuy DeregnaucourtConstance DeschepperJean-Pierre DesechalliersPatrick DesmetPierre DesreumauxGérard DesseauxPhilippe DesurmontAlain DevienneEve DevougeAlex DevrouxArnaud DewaillySébastien DharancyAude Di FioreEmmanuel DiazDjamal DjeddiRachid DjedirWissam DolehMarie-Laure Dreher-DuwatRichard DuboisClothilde DuburqueFrédéric DucrotPhilippe DucrotteAndré DufilhoChristian DuhamelCaroline Dumant-ForestJean-Louis DupasFrédéric DupontYves DurantonArnaud DuriezNicolas DuveauMohammadi El FarisiKhalil El HachkarCaroline ElieMarie-Claire Elie-LegrandMatthieu EocheEssmaeel EssmaeelDominique EvrardJean-Paul EvrardArmelle FatomeKarima Fellah-SekkaiBernard FilocheLaurent FinetMathilde FlahautCamille FlammeDavid FoisseyPeggy FournierPhilippe FoutreinMarie-Christine Foutrein-ComesThierry FrereJulie GalandPhilippe GallaisClaudine GamblinSerge GangaRomain GerardGuillaume GeslinYves GheyssensSalah GhribThierry GilbertBénédicte GilletDenis GodartJean-Michel GodchauxGuetty GoeguebeurOdile GoriaFrédéric GottrandPhilippe GowerLucien GradosBrigitte GrandmaisonMarion GrouxClaire GuedonLoïc GuerbeauMathilde Gueroult-DeroJean-François GuillardLaurence GuillemFrançois A GuillemotDominique GuimberBaya HaddoucheVincent HautefeuillePhilippe HecketsweillerGeneviève HecquetJean-Pierre HeddeHassina HellalPierre-Emmanuel HenneresseMichel HeraudSophie HerveBruno HeymanPatrick HochainPhilippe HouckeLucie Houssin-BailllyBruno HugueninSilviu IobagiuShata IstanboliAlexsandar IvanovicIsabelle Iwanicki-CaronEric JanickiMarine JarryCharlotte Jean BartClaude JonasJulia JougonAnne JouvenetNaeim KassarFadi KatherinAlfred KerleveoAli KhachfeAlfred KiriakosJean KiriakosOlivier KleinMatthieu KohutRichard KornhauserDemetrios KoutsomanisJean-Eric LaberenneEric LacotteGuy LaffineurMarine LagardeAnouck LahayeArnaud LalanneAmbroise LalieuPierre LannoyJosé LapchinMichel LaprandDenis LaudeChristian Le CouteulxCharles Le GofficAlain Le GrixJean-Philippe Le MouelPauline Le RoyRachida LeblancPaul LecieuxStéphane LecleireNathalie LeclercJean LedentJean LefebvrePascale LefilliatreCéline LegrandPatrick LelongBernard LeluyerCaroline LemaitreLucie LepileurAntoine LeplatElodie Lepoutre-DujardinGabriel LeppeutHenri LeroiMaryvonne LeroyBenoît LesageJocelyn LesageXavier LesageIsabelle Lescanne-DarchisDominique LescutBruno LeurentDelphine LeyMichel LhermieLouise LibierBernard LisambertIsabelle LogeJulien LoreauAlexandre LouvetJoséphine LozinguezHenri LubrezDamien LucidarmeJean-Jacques LugandOlivier MacaigneDenis MaetzDominique MaillardHubert MancheronOlivia ManolacheAnne-Bérengère Marks-BrunelCharline MarreRaymond MartiEric MarzloffPhilippe MathurinJacques MauillonVincent MaunouryJean-Luc MaupasMichèle-Ange Medam DjomoChloé MelchiorZiad MelkiBenoît MesnardPatrice MetayerLofti MethariFranck MeurisseLaurent MichaudPatricia ModaineAngélique MontheLoïk MorelMathilde MorinPierre-Eugène MortierPerrine MortreuxOlivier MouterdeNicolas MozziconaciJean MudryMaria NachuriMinh Dung NgoEric Nguyen-KhacBertrand NotteghemVincent OllevierAtika OuraghiBarriza OussadouDominique OuvryBernard PaillotClaire PainchartNicole Panien-ClaudotChristian PaolettiArsène PapazianBruno ParentJean-Claude ParisPhilippe PatrierThierry PaupardBernard PauwelsMathieu PauwelsRichard PetitMuriel PiatSandrine PiotteChristophe PlaneBernard PlouvierEric PolletPierre PommeletDaniela PopCharlotte PordesGérard PouchainPhilippe PradesJean-Christophe PrevostManon PruitGilles QuartierAnne-Marie QueunietJean-François QuintonAlain RabacheGilles RaclotSébastien RatajczykNicole ReixThibaud Renaut-VantroysMarine RevillionGhassan RiachiClémentine RiaultNicolas RichardCécile RichezBenoît RimbertPhilippe RobinsonJuan Daniel RodriguezJean RogerJean-Marc RouxAlain RudelliClémence SaingierGuillaume SavoyePatrick SchlossbergDavid SefriouiMichel SegrestinDavid SeguyCélik SeminurFrançois SevenetJean SilvieClaire SpyckerelleNathalie TalbodecNoémie TavernierHenriette TchandeuAurore TechyJean-Luc TheluHenri ThiebaultJean-Marie ThorelChristophe ThuillierGuillaume TielmanManuella TodeJean TonnelJean-Yves TouchaisAudrey Toulemonde-HuguetPierre ToumelinYvan TouzeLéa TranJean-Luc TranvouezNadia TrikiDominique TurckJustine TurpinEric VaillantClaude ValmageDominique VancoNathalie Vandaele-BertiauxHélène VandammeElise Vander EekenEtienne VanderbercqPhilippe VandermollenPhilippe VandevenneLionel VandevilleAlain VandewalleJean-Pierre VanhooveAudrey VanrenterghemCharlotte VanveurenIona VasiesGuy VerbieseJuliette VerlyndePhilippe VermelleChristine VerneGwenola Vernier-MassouillePerrine Vezelier-CocqJuliette ViartBenoît VigneronMarc VincendetJacques ViotY.M. VoimentJean-Yves WallezMichel WantierFaustine WartelJean-Christian WeberJean-Louis WillocquetNathalie WizlaEric WolschiesTajiogue YimforOana ZaharaAlberto ZalarSonia ZaouiAnne Zellweger
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital Saint Philibert [Lomme] Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Institute for Translational Research in Inflammation - U 1286 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier de Dunkerque Hôpital privé les Bonnettes [Arras] Institute for Translational Research in Inflammation - U 1286 Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Hôpital universitaire Robert Debré [Reims] Institute for Translational Research in Inflammation - U 1286 Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Institute for Translational Research in Inflammation - U 1286 Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD CHU Amiens-Picardie Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD Registre EPIMAD CHU Amiens-Picardie Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV
• Publié dans The Lancet Regional Health - Europe le 21/04/2021

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Résumé : Background: In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Methods: Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. Findings: A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn's disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 105 person-years, respectively. The incidence of CD increased from 5.1/105 in 1988-1990 to 7.9/105 in 2015-2017 (annual percent change (APC): +1.9%, p < 0.0001). The incidence of UC increased from 4.5/105 to 6.1/105 (APC: +1.3%, p < 0.0001). The largest increase was observed in children (+4.3% in CD, p < 0.0001; +5.4% in UC, p < 0.0001) followed by young adults aged 17-39 years (+1.9% in CD, p < 0.0001; +1.5% in UC, p < 0.0001). The increase in UC incidence was significantly higher in women than in men (+1.9% in women, +0.8% in men; p = 0.006). We estimated that in our area, by 2030, nearly 0.6% of the population will have IBD. Interpretation: The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors.

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Fichiers liés : EPIMAD LANCET REG HEALTH 2024.pdf

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