Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Jérôme RoncalliFrançois RoubilleYves CottinLionel LerouxAnthony MathurJohn IrvingSohail Q KhanNicolas MeneveauDidier BressonThomas HovasseGiulio PompilioAnthony MattaPhilippe HenonGuillaume TrebuchetMatthieu de KalbermattenIbon GaritaonandiaEric SalouxAlain ManriqueNicolas MeyerPierre-Yves MarieDeepak BhattScott D SolomonGilles MontalescotDavid E NewbyFaiez Zannad
• Organismes : Service Cardiologie [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Module Biothérapies CHU Montpellier = Montpellier University Hospital Service de Cardiologie [CHU de Dijon] Département de cardiologie Barts Heart Centre [London, UK] Barts Health NHS Trust [London, UK] Ninewells Hospital and Medical School [Dundee] Queen Elizabeth Hospital University Hospitals Birmingham [Birmingham, Royaume-Uni] NHS Foundation Trust [London] Hôpital Jean Minjoz [Besançon] Centre Hospitalier Emile Muller [Mulhouse] Institut Cardiovasculaire Paris Sud Centro Cardiologico Monzino [Milano] Università degli Studi di Milano = University of Milan Service Cardiologie [CHU Toulouse] Institut des Maladies Métaboliques et Casdiovasculaires Module Biothérapies CellProthera CellProthera CellProthera CellProthera Service de cardiologie et de pathologie vasculaire [CHU Caen] Service de médecine nucléaire [CHU Caen] Groupe Méthodes en Recherche Clinique [Strasbourg] Défaillance Cardiovasculaire Aiguë et Chronique Service de Médecine Nucléaire [CHRU Nancy] Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire Mount Sinai Fuster Heart Hospital Icahn School of Medicine at Mount Sinai [New York] Brigham and Women's Hospital [Boston] Harvard Medical School [Boston] CHU Pitié-Salpêtrière [AP-HP] Groupe Action British Heart Foundation Centre of Research Excellence The University of Edinburgh Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris]
• Publié dans JACC: Heart Failure le 29/10/2020

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Fichiers liés : 1-s2.0-S2213177925005542-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Avi SabbagNina Ajmone-MarsanFatima EzzeddineGuido AscioneNicolò Azzola GuicciardiPierre BaudinaudRoy BeinartMouna Ben KilaniMarco BergontiPriya Kumar BhardwajSerge BovedaCsilla CzimbalmosLuca CristinGiulio ConteFreddy del CarpioFrancesca N DellingMarta de RivaJean-Claude DeharoWilliam EscandeJonaz FontDeborah FoltranFederico GuerraCharles GuenanciaKristina HaugaaChristelle HaddadAlexis HermidaOlivier HuttinPeggy JaconAlice KrebsováMikael LaredoHan S LimPilar López-SantiPhilippe MauryJacques MansouratiAnat MilmanEfrat MazorAndrea NagyAndrzej PrzybylskiMagdi SabaChristian SohnsChristian SticherlingKonstantinos C SiontisRachel M.A. ter BekkeRomain TixierMoshe Rav AchaRobin Richard-VittonBo Gregers WinkelPierre OllitraultEivind Aabel
• Organismes : Chaim Sheba Medical Center Tel Aviv University Hôpital Européen Georges Pompidou [APHP] Chaim Sheba Medical Center Tel Aviv University Centre Hospitalier Universitaire d'Angers Clinique Pasteur [Toulouse] Fondazione Cardiocentro Ticino Hôpital de la Timone [CHU - APHM] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research IHU-LIRYC Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Cardiologie [CHU Amiens] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

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Résumé : Background Arrhythmic mitral valve prolapse (AMVP) is a cause of sustained ventricular tachyarrhythmias (VAs) and sudden cardiac death (SCD), but the arrhythmias remain only partially understood. Objectives In this worldwide collaboration, this study aimed to characterize the VAs occurring in AMVP patients, explore factors associated with various types of sustained VA, and describe common triggering mechanisms. Methods In this multicenter retrospective cohort study, we collected patients with AMVP and documented VA. Clinical and imaging data, and detailed data of the arrhythmic events were collected. In addition, electrocardiograms or intracardiac tracings capturing the arrhythmic events were analyzed by a core laboratory. Results We included 225 patients from 35 centers (age 44 ± 17 years, 57% female). Late gadolinium enhancement (LGE) was found in 61%. We collected 278 arrhythmic events, of which ventricular fibrillation (VF) was the most frequent (65%), followed by sustained monomorphic ventricular tachycardia (SMVT; 26%). Triggers were most commonly exercise or stress (37%), but 31% had no discernable trigger. SMVT was associated with increasing age (P = 0.03), family history of SCD (P = 0.03), history of syncope (P = 0.05), and myocardial LGE (P = 0.003). Of the 278 events, 140 (50%) had available tracings, where 25% of events were triggered by a short-coupled premature ventricular contraction. Pause-dependent initiation was most frequent (49%), and more likely to lead to VF than to SMVT (P = 0.01). Conclusions The dominant VA in AMVP was VF, although SMVT was also common and associated with older age, family history of SCD, syncope, and myocardial LGE. The most common initiation was pause dependent leading to VF.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Pierre-André LafonLaurent PrézeauJean-Philippe PinPhilippe Rondard
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans Trends in Pharmacological Sciences le 25/10/2020

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Résumé : Camelid-derived nanobodies offer a promising alternative to conventional antibodies for the treatment of brain disorders. Their current development in models of schizophrenia or Alzheimer's disease highlights their strong therapeutic potential. Optimizing their delivery and ensuring their safety are major challenges, but their modularity and low immunogenicity make them promising candidates for neurotherapy.

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Fichiers liés : Lafon et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Philippe RyvlinMargaux HuotLuc ValtonLouis MaillardFabrice BartolomeiPhilippe DerambureEdouard HirschVéronique MichelFrancine ChassouxJérôme PetitArielle CrespelArnaud BirabenVincent NavarroPhilippe KahaneBertrand de ToffolPierre ThomasSarah RosenbergAdriano BerniniAnne-Laure CharloisLaura CraciunFatima ChorfaPauline DucouretAxel FerreiraMathilde LeclercqManon MartyBlanca Mercedes AlvarezMilena SampaioAntoine SpahrNoémie Timestit-KurlandMaylis TouyaPascal RoySylvain RheimsC AdamN Andre-ObadiaS AubertFabrice BartolomeiJ BiberonA BirabenFb BoniniSébastien BoulogneV BourgH CatenoixF ChassouxA CrespelJc CurotMd DamianoM de MontaudouinB de ToffolM DenuelleP DerambureSamuel DupontV EidV FrazziniP GelisseE HirschJ IsnardAs JobJ JungP KahaneSl LagardeE LandreP LatourL MaillardC MarchalA Mc GonigalV MichelL MinottiA MontavontV NavarroVh Nguyen-MichelA NicaJ PetitFp PizzoSylvain RheimsSr RosenbergFr RulquinP RyvlinCs SabourdyM SampaioW SzurhajP ThomasD TourniaireAt TrébuchonL TyvaertMp ValentiL ValtonL VercueilJp Vignal
• Organismes : Institut des Epilepsies de l'Enfant et de l'Adolescent Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre de recherche cerveau et cognition Centre Hospitalier Universitaire de Toulouse Ingénierie Moléculaire, Cellulaire et Physiopathologie Service de neurologie [CHRU Nancy] Institut de Neurosciences des Systèmes Service d'Epileptologie et de Rythmologie Cérébrale [Hôpital de la Timone, AP-HM] Service de neurophysiologie clinique Pharmacologie de la mort neuronale et de la plasticité cérébrale Centre de référence des épilepsies rares [CHRU Strasbourg] Service de Neurologie [Strasbourg] Service de neurologie [Bordeaux] Service de neurochirurgie [AP-HP Hôpital Lariboisière] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Centre Médical de la Teppe Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Institut National de la Santé et de la Recherche Médicale Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Régional Universitaire de Tours Inserm U930 Imagerie et Cerveau Service de Neurologie [CHU Nice] Service Neurologie [CHU Clermont-Ferrand] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Hospital General Universitario "Gregorio Marañón" [Madrid] Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service du sommeil, de l'épilepsie et de neurophysiologie pédiatrique clinique [Hospices Civils de Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans The Lancet Neurology le 27/10/2020

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Fichiers liés : 1-s2.0-S1474442225003795-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2025
• Auteurs : Gaspard SucJulien DreyfusJulien TernacleThierry Le TourneauPhilippe DemersLinrui GuoAngel Yi Nam FuJean Claude DibMohammad Al FadhalahThays SokolovAmedeo AnselmiDidier TchétchéOphélie Brault MeslinAnge GoutondjiYoan Lavie-BadiePatrick SeknadjiAugustin CoisneDimitri ArangalageAnne BernardUsha ManianMalek KassAntonio FioreArnaud MaudiereYohann BohbotAurélien SeemannNadjib HammoudiLoïc BièrePierre-Yves LerouxJessica ForcilloAntoine JeuMohammed NejjariOlivier HuttinMartine GilardClaire BouletiDavid HarnettJean-Francois LegareThiziri Si MoussiJian YeCatherine SportouchBindu BittiraLaura MunteFabrice BauerHoward Leong-PoiAli Fatehi HassanabadThomas ModineJordan BernickGeorge WellsRoja GaudaBernard IungWilliam KentMichael W.A. ChuDenis BouchardJean-François ObadiaDavid Messika-Zeitoun
• Organismes : University of Ottawa Heart Institute Centre cardiologique du Nord CHU de Bordeaux Pellegrin [Bordeaux] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Institut du Thorax [CHU Nantes] Montreal Heart Institute - Institut de Cardiologie de Montréal University of Western Ontario University of Ottawa Heart Institute Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] St. Paul’s Hospital - University of British Columbia [Vancouver, BC, Canada] Hospices Civils de Lyon Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Clinique Pasteur [Toulouse] Institut Mutualiste de Montsouris CHU Dijon Centre Hospitalier Universitaire de Toulouse Hôpital Privé Jacques Cartier [Massy] Centre Hospitalier Régional Universitaire [CHU Lille] Cardiovascular Research Foundation [New York, NY, USA] Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Pasteur de Lille Laboratoire de Recherche Vasculaire Translationnelle Institut de neurophysiopathologie Hôpital Henri Mondor CHU Marseille Cardiologie [CHU Amiens] Mécanismes physiopathologiques et conséquences des calcifications cardiovasculaires - UR UPJV 7517 CHU Pitié-Salpêtrière [AP-HP] University of Ottawa Heart Institute Montreal Heart Institute - Institut de Cardiologie de Montréal Hospices Civils de Lyon University of Ottawa Heart Institute
• Publié dans Canadian Journal of Cardiology le 01/11/2020

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Résumé : Background Calcified mitral valve disease (CMVD) is an increasingly recognized condition associated with specific management challenges. MITRACURE, a large multicenter observational registry conducted in France and Canada, provides real-world insights into the characteristics and outcomes of patients with CMVD undergoing MV surgery. Methods Among the 3,522 patients included in MITRACURE, patients identified with CMVD were matched 4:1 for age, sex, and concomitant procedures with patients with myxomatous MV disease. Results Sixty patients (2%) with CMVD were matched to 240 with myxomatous MV disease. Compared to the myxomatous cohort, CMVD patients had a greater burden of cardiovascular risk-factors, more comorbidities, and a more advanced presentation, with 70% vs. 52% in NYHA class III–IV (P=0.01). In-hospital mortality and major complication rates (composite of death, cardiogenic shock/low cardiac output requiring inotropes, acute renal failure requiring dialysis, and stroke or transient ischemic attack) were significantly higher in CMVD than myxomatous patients (20% vs. 4%, and 38% vs. 20%, both P<0.01). Median EuroSCORE II was slightly higher in CMVD patients (3.5 [IQR 2.2-5.7]) compared with those with myxomatous disease (2.6 [IQR 1.5-4.2], P<0.01). However, the observed mortality in the CMVD group was three to four times higher than predicted, whereas in the myxomatous group it was consistent with predicted values. Conclusion CMVD defines a high-risk surgical population with substantial baseline cardiovascular morbidity and markedly elevated postoperative mortality and complication rates that were substantially underestimated by EuroSCORE II emphasizing the need for refined risk prediction models and individualized management strategies in this subset of patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Boris JungMathieu JabaudonAudrey de JongLaurent laurent-bitker BitkerJules AudardKada KloucheBenjamine SartonChristophe GuittonSigismond LasockiBenjamin RieuEmmanuel CanetCaroline JeantrelleAntoine RoquillyJulien MayauxFranck VerdonkJulien PottecherMartine FerrandiereBeatrice RiuPierre GarconMona AssefiPhilippe DetoucheJean Marie ForelClaire Penetrat-RogerJeremy BourenneSophie JacquierDavid BougonAmelie RollePhilippe CorneNacim BenchabaneJean Christophe RichardKarim AsehnouneGerald ChanquesJean-Baptiste LascarrouFoud BelafiaMaxime FossetHelena HuguetEmmanuel FutierNicolas MolinariSamir JaberSonia MachadoVincent BrunotLaura PlatonDelphine DaubinNoémie BesnardValérie MoulaireCorinne PelleLiliane LandreauGuillaume DeneilHodane YonisMehdi MezidiLouis ChauvelotS. SilvaPatrice TirotCedric DarreauNicolas ChudeauMaeva CampfortSoizic GergaudLoris GiordanettoThomas GodetJean-Baptiste LascarrouJean-Baptiste LascarrouMikahel GiabicaniKarim AshenouneYannick HourmantAlexre BourdiolCécile PoulainAlexre DemouleMartin DresMaxens DecavèleMarie LecronierCôme BureauJulien Do ValeSophie MenatSebastien ClercJeremie PichonJennifer CatanoAdam CelierValentine Le StangMarie-Claire DiemozHugo Flis-RichardEmmanuel PardoNatacha KapandjiAlain MeyerStephane HecketsweilerPaer Selim AbbackLy van Phach VongDelphine ReitterJonathan ZarkaJean Michel ConstantinFlorence DavietLaurent MullerJean Yves LefrantStephan EhrmannCharlotte Salmon GinniereLaëtitia Bodet-ContentinJulien CarvelliMarc GainierBernard CholleyJean DellamonicaMathieu JozwiakClement SacchieriAlexandre LautretteMartin CourLaurent ArgaudThomas RimmeleSebastien PreauXavier CapdevilaMaud FiancetteDamien RouxJulien BohePierre AsfarRussel ChabanneNicolas TerziNaïke BigeAude GarneroDjamel MokartHatem Kallel
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nîmes Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans JAMA Cardiology le 25/10/2020

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Résumé : Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with day 90 all-cause mortality in patients with severe metabolic acidemia and moderate to severe acute kidney injury. Design, Setting, and Participants Randomized, open-label, clinical trial conducted with 640 patients in 43 French intensive care units from October 6, 2019, to December 19, 2023, with 90-day follow-up. The last date of follow-up was June 17, 2024. Adults with severe metabolic acidemia (defined as pH ≤7.20) and moderate to severe acute kidney injury were enrolled. Intervention Patients were randomized 1:1 to receive either intravenous sodium bicarbonate infusion or no sodium bicarbonate to target an arterial pH of 7.30 or higher. Main Outcomes and Measures The primary outcome was day 90 all-cause mortality. Secondary outcomes included day 28 and day 180 all-cause mortality; use of organ support therapy, vasopressors, or invasive mechanical ventilation; intensive care unit and hospital length of stay; intensive care unit–acquired infections; fluid balance; day-7 Sequential [Sepsis-related] Organ Failure Assessment score (6 organ systems’ function is evaluated and scored from 0 [no dysfunction] to 4 [failure]; total score ranges from 0 [normal] to 24 [maximum failure]); and major adverse kidney events on day 90. Results Among 640 randomly assigned patients, 627 were analyzed (313 in the control group and 314 in the bicarbonate group). The median age was 67 years (IQR, 59-74 years); 194 of 314 patients (62%) in the bicarbonate group and 185 of 313 controls (59%) were male. In the primary analysis, day 90 all-cause mortality was 195 of 314 patients (62.1%) in the bicarbonate group and 193 of 313 (61.7%) in the control group (absolute difference, 0.4; 95% CI, −7.2 to 8.0; P = .91). There was no evidence of a group effect on day 28 or day 180 all-cause mortality. Among 18 secondary outcomes, kidney replacement therapy was used in 109 of 314 (35%) bicarbonate group patients and 157 of 313 (50%) controls (absolute difference, −15.5; 95% CI, −23.1 to −7.8). No evidence of a group effect was found on other secondary outcomes, including adverse events. Conclusions and Relevance For patients with severe metabolic acidemia and moderate to severe acute kidney injury, intravenous sodium bicarbonate did not affect mortality. Trial Registration ClinicalTrials.gov Identifier: NCT04010630

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Fichiers liés : 2025 Jung et al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Jonas VanardoisPierre TrapPhilippe GoncalvesRoger FrançoisePierre LanariFrancesca PiccoliDidier MarquerJean-Louis PaquetteJérémie Melleton
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Université de Lausanne = University of Lausanne Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Géosciences Montpellier Université de Lausanne = University of Lausanne Universität Bern = University of Bern = Université de Berne Universität Bern = University of Bern = Université de Berne Laboratoire Magmas et Volcans Laboratoire Magmas et Volcans Bureau de Recherches Géologiques et Minières
• Publié dans Bulletin de la Société Géologique de France le 28/10/2020

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Résumé : This study investigates the P-T-t-D evolution of two metapelitic samples from the middle crust exposed in the Aiguilles Rouges Massif. Garnet compositional mapping, phase equilibrium modelling, zirconium-in-rutile thermometry, trace element geochemistry of garnet and monazite, and U-Pb LA-ICP-MS dating on monazite were used to better understand the tectonic and thermal history of the variscan External Crystalline Massifs. In the sample representing the upper-middle crust (AR736, southwestern part of the massif), using the preserved mineral assemblage in garnet inclusion

and garnet compositions, the prograde P-T path was constrained from ∼0.5-0.6 GPa and 550-625 °C to ∼0.76-0.82 GPa and 600-640 °C. The P-T conditions at the onset of this prograde evolution suggest a high geothermal gradient (∼30-35 °C/km) prior to the onset of crustal thickening. In the sample representing the lower-middle crust (AR14, central part of the massif), using the preserved mineral assemblage in garnet inclusion

, the occurrence of sillimanite and ilmenite in the matrix and garnet compositions, a b-shaped P-T path characterised by a late temperature increase during exhumation was identified. Both samples recorded a retrograde P-T stage at ∼0.4 GPa and 545 °C, dated at 315-305 Ma. Microstructural analysis indicates dextral transcurrent deformation from the late crustal thickening stage to the exhumation phase. Comparison with previously published P-T paths from eclogitic lenses highlights the juxtaposition of middle and lower crustal domains during dextral transcurrent deformation. We propose a tectonic model in which the formation of supra-subduction volcano-sedimentary basins (∼350 Ma) is followed by crustal thickening between 350 and 340 Ma under a thermal gradient of ∼5-15 °C/km. The exhumation of the lower and middle crust took place in a transcurrent regime between 340 and 305 Ma. This prolonged transcurrent tectonic activity suggests that the numerous transcurrent shear zones in the Variscan belt are not merely late orogenic structures but played a significant role in the geodynamic evolution, particularly in the exhumation of the orogenic crust, from the end of continental collision to the closure of the Variscan orogeny.

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Fichiers liés : bsgf230022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Nathalie DemaureJehanne Le CunffMaryline DuchêneBertrand RozecFabien EspitalierJean-Michel CabonJean-Ferréol OilleauPhilippe GuerciFrançois LabasteOsama Abou-ArabPierre-Grégoire GuinotPierre DuvalEmmanuel BesnierErwan FlécherIsabelle LeroyerJeff MorcetClaire Fougerou-LeurentAlexandre MansourNicolas Nesseler
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Service d'anesthésie et réanimation chirurgicale [Nantes] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Trousseau [Tours] CHRU Brest - Département d'Anesthésie Réanimation CHRU Brest - Département d'Anesthésie Réanimation Service d'Anesthésie et Réanimation [CHRU Nancy] Pôle Anesthésie Réanimation [CHU de Toulouse] CHU Amiens-Picardie Université de Franche-Comté Service d'Anesthésie et Soins intensifs [CHU Rouen] Service d'Anesthésie et Soins intensifs [CHU Rouen] Centre Hospitalier Universitaire [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire [Rennes] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction Postoperative pulmonary complications (PPCs) are common after cardiac surgery and are associated with significant morbidity and mortality. Lung-protective ventilation strategies have been proposed to reduce PPCs, but the optimal level of positive end-expiratory pressure (PEEP) and the use of alveolar recruitment manoeuvres (RMs) remain controversial. Methods/analysis In this investigator-initiated, multicentre, open, randomised, parallel-group, superiority clinical trial, elective cardiac surgery patients at risk of PPCs will be assigned to one of two intraoperative ventilation strategies: (1) an open-lung ventilation strategy with protective ventilation, moderate PEEP and RMs or (2) a standard protective ventilation with low PEEP and no RM. The primary outcome will be a composite of prolonged (>24 hour) postoperative mechanical ventilation, reintubation for any cause or hospital-acquired pneumonia within 7 days of surgery, or death within 28 days of surgery. Data will be analysed on an intention-to-treat basis. Ethics and dissemination The VACARM (impact of intraoperatiVe moderAte positive end-expiratory pressure with reCruitment mAnoeuvres versus low positive end-expiRatory pressure on major postoperative pulMonary complications and death after on-pump cardiac surgery in high-risk patients) trial has been approved by an independent ethics committee for all study centres. Recruitment began in July 2021. Results will be published in international peer-reviewed medical journals. Trial registration number ClinicalTrials.gov NCT04408495 .

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Fichiers liés : e104179.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2025
• Auteurs : Iwona PrankeValeria CapurroBenoit ChevalierEmanuela PesceValeria TomatiCristina PastorinoMairead Kelly-AubertAurelie HattonElise DreanoMariateresa LenaRenata BocciardiFederico ZaraStefano PantanoVito TerlizziCristina LucantoStefano CostaLaura ClautValeria DaccòPiercarlo PoliMassimo MaschioBenedetta FabrizziNicole CaporelliMarco CipolliSonia VolpiFrederique ChedevergneLaure CossonJulie MaceySophie RamelLaurence WeissDominique GrenetLaurence Le Clainche-VialaBenoit DouvryBruno RavoninjatovoCamille AudoussetAurélie TatopoulosBénédicte Richaud-ThiriezMelissa BaravalleGuillaume ThouveninGuillaume LabbéMarie MittainePhilippe ReixIsabelle DurieuJulie MankikianStéphanie BuiThao Nguyen‐khoaKarim KhoukhClémence MartinJennifer da SilvaPaola de CarliCarlo CastellaniFederico CrestaLuis GaliettaAnne GuillemautEmmanuelle GirodonNatacha RemusMathis BulcaenMarjolein EnsinckMiroslaw ZajacMarianne CarlonJean LebihanPierre-Régis BurgelIsabelle Sermet-GaudelusAlexandre HinzpeterNicoletta Pedemonte
• Organismes : Research on Healthcare Performance
• Publié dans Frontiers in Pharmacology le 25/10/2020

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Résumé : Rationale Respiratory status of people with Cystic Fibrosis (pwCF) carrying N1303K is improved by Elexacaftor/Tezacaftor/Ivacaftor (ETI) but, contrary to other mutations, the impact on sweat test results is limited. Methods To explore this discrepancy, we implemented new sweat gland and respiratory cell lines stably expressing Wild type (WT)-, F508del- and N1303K-CFTR. CFTR dependent chloride (Cl − ) and bicarbonate (HCO 3 -) transport was measured by short circuit current in these new models and in primary Human Nasal Epithelial Cells (HNECs). CFTR expression was evaluated by Western blot. Results In the airway and the sweat gland cells expressing F508del-CFTR, ETI induced maturation of CFTR and increased Cl − transport. In the respiratory cell lines and HNECs, N1303K-CFTR generated both immature and mature forms of CFTR. Correction by ETI increased CFTR amounts without promoting its maturation and improved Cl − secretion. N1303K-CFTR channel activity was markedly increased by co-potentiation of IVA with Apigenin. In the sweat gland, N1303K-CFTR was expressed as a globally misfolded protein, non-rescuable by ETI. API treatment to 2 patients improved FEV1 without lowering sweat Cl- content. Conclusion N1303K-CFTR shows tissue specific correction and suboptimal response to ETI which can be improved by API.

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 28/10/2025
• Auteurs : Ibrahim Jaser AbualrobShreyasi AcharyaGianluca Aglieri RinellaLuca AgliettaMichelangelo AgnelloNeelima AgrawalZubayer AhammedShakeel AhmadIshaan AhujaZulkaida AkbarAlexander AkindinovValentina AkishinaMohammad Al-TuranyDmitry AleksandrovBruno AlessandroJose Ruben Alfaro MolinaBushra AliAndrea AliciAnton AlkinJohan AlmeGiacomo AloccoTorsten AltAnna Rita AltamuraIgor AltsybeevCristian AndreiNicodemos AndreouAnton AndronicEvgeny AndronovVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaHarald AppelshaeuserSilvia ArcelliRoberta ArnaldiJhoao Gabriel Martins Campos Almeida ArneiroIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckMohd Danish AzmiHitoshi BabaAkash Raj John BabuAngela BadalaJoonsuk BaeYunseul BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungRenu BalaAlberto BaldisseriBartosz BalisShubham BangaliaZarina BanooVeronika BarbasovaFrancesco BarileLuca BarioglioMaria BarlouBanajit BarmanGergely Gabor BarnafoldiLee Stuart BarnbyEmilie Martine BarreauValerie Ramillien BarretLeonardo Barreto de Oliveira CamposKlaus BarthEsther BartschNicole BastidGuillaume BatigneDaniel BattistiniBoris BatyunyaDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenPascal BechtDebadatta BeheraSwadhin BeheraIouri BelikovValerio Di BellaFrancesca BelliniRene BellwiedLucina Gabriela Espinoza BeltranYael Antonio Vasquez BeltranGyula BencediAdel BensaoulaStefania Maria BeoleYaroslav BerdnikovAnastasia BerdnikovaLuisa BergmannLorenzo BernardinisLatchezar BetevPartha Pratim BhaduriTushar BhallaAnju BhasinBuddhadeb BhattacharjeeSumit BhattaraiLivio BianchiJaroslav BielcikJana BielcikovaAnte BilandzicAnna BinoyGabor BiroSaikat BiswasDmitry BlauMihail Bogdan BlidaruNora BluhmeChristoph BlumeFriederike BockTea BodovaJeongsu BokLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoElena BottaYoussef El Mard BouzianiDiana Catalina BrandiburLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoValentin Dimitrov BuchakchievMatthew Daniel BucklandHenner BueschingStefania BufalinoPaul Alois BuhlerNazar BurmasovEdith Zinhle ButheleziAleksandr BylinkinChristopher Alfred CarrJuan Carlos Cabanillas NorisMaria Fernanda Torres CabreraHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniMaria Teresa CamerlingoFabio de Moraes CanedoStefano CannitoSierra Lisa CantwayMihai CarabasFrancesca CarnesecchiLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosMatteo CastoldiFabio CatalanoSamuele CattaruzziRebecca CerriIrakli ChakaberiaPritam ChakrabortyJustin Wei Ong ChanSinjini ChandraSylvain ChapelandMarielle ChartierSouvik ChattopadhayMeiyi ChenTiantian ChengCvetan Valeriev CheshkovDavide ChiapparaVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoFabrizio ChinuEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaZuzanna Anna ChochulskaPanagiotis ChristakoglouChristian Holm 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Résumé : In this letter, the first measurement of the femtoscopic correlation of protons and $Σ^+$ hyperons is presented and used to study the p$-Σ^+$ interaction. The measurement is performed with the ALICE detector in high-multiplicity triggered pp collisions at $\sqrt{s} = 13$ TeV. The $Σ^+$ hyperons are reconstructed using a missing-mass approach in the decay channel to $\textrm{p} + π^0$ with $π^0\rightarrowγγ$, while both $Σ^+$ and protons are identified using a machine learning approach. These techniques result in a high reconstruction efficiency and purity, which allows the measurement of the p$-Σ^+$ correlation function for the first time. Thanks to the high significance achieved in the p$-Σ^+$ correlation signal, it is possible to discriminate between the predictions of different models of the N$-Σ$ interaction and to accomplish a first determination of the p$-Σ^+$ scattering parameters.

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