Philippe Jean-Pierre
Professeur des universités en sciences de gestion
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Probing the flavour structure of dimension-6 EFT operators in multilepton final states in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/08/2025
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesThiago TomeiEduardo 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RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinLev DudkoKirill IvanovVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
Probing the flavour structure of dimension-6 EFT operators in multilepton final states in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/08/2025
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMilena MishevaMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinXiaohu SunDayong WangJin WangHeng YangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerBolin LiHui WangKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouAndreas HadjiagapiouChristos LeonidouCharalambos NicolaouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinAhmed Ali AbdelalimReham AlyMuhammad Abdullah Abdulfattah MuhammadAhmed HusseinHemida MohammedKarl EhatahtMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniAnna MilievaKenneth OsterbergMikko VoutilainenNurfikri Bin NorjoharuddeenErik BrückenFrancisco Ignacio Garcia 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RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinLev DudkoKirill IvanovVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
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Résumé : An analysis of the flavour structure of dimension-6 effective field theory (EFT) operators in multilepton final states is presented, focusing on the interactions involving Z bosons. For the first time, the flavour structure of these operators is disentangled by simultaneously probing the interactions with different quark generations. The analysis targets the associated production of a top quark pair and a Z boson, as well as diboson processes in final states with at least three leptons, which can be electrons or muons. The data were recorded by the CMS experiment in the years 2016$-$2018 in proton-proton collisions at a centre-of-mass energy of 13 TeV and correspond to an integrated luminosity of 138 fb$^{-1}$. Consistency with the standard model of particle physics is observed and limits are set on the selected Wilson coefficients, split into couplings to light- and heavy-quark generations.
Source -
Search for resonant production of pairs of dijet resonances through broad mediators in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/08/2025
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesThiago TomeiEduardo 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CardwellHeewon ChungBradley CoxJohn HakalaRobert HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoSergey PolikarpovOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinLev DudkoKirill IvanovVictor KimVictor MurzinVadim OreshkinDmitry Sosnov
Search for resonant production of pairs of dijet resonances through broad mediators in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/08/2025
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutJoscha KnolleLuka LambrechtDavid MarckxKirill SkovpenNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesThiago TomeiEduardo 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RoguljicSanjana SekharMohit Vir SrivastavMorris SwartzAndrés AbreuLuis Fernando Alcerro AlcerroJustin AnguianoSaray Arteaga EscatelPhilip BaringerAlice BeanZachary FlowersDerek GroveJack KingGeorgios KrintirasMargaret LazarovitsCole Le MahieuJuan MarquezMichael MurrayMatthew NickelSorina PopescuChristopher RoganChristophe RoyonSahithi RudrabhatlaStephen SandersCaleb SmithGraham WilsonBraden AllmondGujju Gurunadha ReddyNaila IslamAndrew IvanovKetino KaadzeYurii MaravinJames NatoliDennis RoyGiulia SorrentinoDrew BadenAlberto BelloniJoshua Bistany-RiebmanSarah Catherine EnoNicholas John HadleyShabnam JabeenRichard G KelloggTimothy KoethBraden KronheimSamuel LascioPéter MajorAlice MignereyChristopher PalmerChristos PapageorgakisMekhala Mahesh ParanjpeElena PopovaAlexey ShevelevLicheng ZhangCristian Baldenegro BarreraJoshua BendavidHannah BossiSamuel Bright-ThonneyIvan Amos CaliYu-Chen ChenPin-Chun ChouMariarosaria d'AlfonsoJan EysermansChad FreerGuillelmo Gomez CeballosMaxim GoncharovGaia 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Michael MorseToyoko OrimotoAshley ParkerLouise SkinnariCort Stewart ThoresonEmily TsaiDarien WoodSusan DittmerKristian Allan HahnYihan LiuMichael McginnisYulun MiaoDavid Gabriel MonkMichael Henry SchmittAngela TaliercioMayda VelascoJinglu WangGarvita AgarwalReyer BandRachael BucciSergi CastellsAbhishek DasAmanda EhnisReza GoldouzianMichael HildrethKenyi Hurtado AnampaTodor IvanovColin JessopAnton KarneyeuKevin LannonJohn LawrenceNikitas LoukasDylan LuttonJoseph MarianoNancy MarinelliIan McalisterThomas MccauleyChristopher McgradyConnor MooreYuri MusienkoHannah NelsonMarc OshersonAndrea PiccinelliRandy RuchtiAustin TownsendYuyi WanMitchell WayneHenry YockeyAashwin BasnetMichael CarriganRyan de los SantosLloyd Stanley DurkinChristopher HillMatthew JoyceMartha Nunez OrnelasDerek Albert WenzlBrian L WinerBrent YatesHichem BouchamaouiKathryn ColdhamPallabi DasGage DezoortPeter ElmerAndre FrankenthalMassimiliano GalliBennett GreenbergNicholas HaubrichKiley KennedyGillian KoppYihui LaiDavid LangeAndrew LoeligerDaniel MarlowIsabel OjalvoJames OlsenFarrah SimpsonDavid SticklandChristopher TullySudhir MalikRicha SharmaAmandeep Singh BakshiSoumik ChandraRidhi ChawlaAn GuLaszlo GutayMatthew JonesAndreas Werner JungDmitry KondratyevMiaoyuan LiuGiulia NegroNorbert NeumeisterGaryfallia PaspalakiStefan PiperovJan-Frederik SchulteFuqiang WangAndrew WildridgeWei XieYao YaoYibo ZhongNeeti ParasharAtanu PathakElton ShumkaDarin AcostaAman AgrawalCollin ArbourTaylor CarnahanKarl Matthew EcklundPedro José Fernández MantecaSarah FreedParker GardnerFrank J.M GeurtsTao HuangIason KrommydasNicole LewisWei LiJiazhao LinOsvaldo Miguel ColinBrian Paul PadleyRadia RedjimiJohn RotterEfe YigitbasiYousen ZhangOlga Bessidskaia BylundArie BodekPawel de BarbaroRegina DeminaJoseph Lynn DulembaAran Garcia-BellidoHonor Suzanne HareOtto HindrichsNukulsinh ParmarPavel ParyginHyonsan SeoRhys TausBrandon ChiaritoJohn Paul ChouSteven Vincent ClarkSean DonnellyDivya GadkariYuri GershteinEva HalkiadakisMaximilian Perez PradaConnor HoughtonDavid JaroslawskiSotiroulla KonstantinouIan LaflotteAmitabh LathJordan MartinsBenjamin RandJoseph ReichertPrafulla SahaSevil SalurSteve SchnetzerSunil SomalwarRobert StoneSteffie Ann ThayilScott ThomasJay VoraDaniel AllyAndrés G DelannoySara FiorendiJesse HarrisSamuel HigginbothamTova HolmesAnkush Reddy KanugantiNimmitha KarunarathnaJohn LawlessLawrence LeeEmery NibigiraBrandi SkipworthStefan SpanierDevin AebiMuhammad AhmadTowsifa AkhterKonstantin AndrosovArtem BolshovOthmane BouhaliRicardo EusebiPatrick FlanaganJason GilmoreYumeng GuoTeruki KamonSifu LuoRyan MuellerAlexei SafonovNural AkchurinJordan DamgovYongbin FengNiramay GogateYelbir KazhykarimKamal LamichhaneSung Won LeeChristopher MadridAaron MankelTimo PeltolaIgor VolobouevEric AppeltYi ChenSenta GreeneAlfredo GurrolaWillard JohnsRaghav Kunnawalkam ElayavalliAndrew MeloDenis RathjensFrancesco RomeoPaul SheldonShengquan TuoJulia VelkovskaJussi ViinikainenJingyu ZhangBryan CardwellHeewon ChungBradley CoxJohn HakalaRobert HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoSergey PolikarpovOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinLev DudkoKirill IvanovVictor KimVictor MurzinVadim OreshkinDmitry Sosnov
- Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Laboratoire Leprince-Ringuet Institut Pluridisciplinaire Hubert Curien Université de Haute-Alsace (UHA) Mulhouse - Colmar Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Centre de Calcul de l'IN2P3 Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon Institut de Physique des 2 Infinis de Lyon
Résumé : A reinterpretation of a prior narrow-resonance search is performed to investigate the resonant production of pairs of dijet resonances via broad mediators. This analysis targets events with four resolved jets, requiring dijet invariant masses greater than 0.2 TeV and four-jet invariant masses greater than 1.6 TeV. The search uses a data sample corresponding to an integrated luminosity of 138 fb$^{-1}$ collected by the CMS experiment in proton-proton collisions at $\sqrt{s}$ = 13 TeV. The reinterpretation considers the production of new heavy four-jet resonances, with widths ranging from 1.5 to 10% of their mass, which decay to a pair of dijet resonances. This analysis probes resonant production in the four-jet and dijet mass distributions. Upper limits at 95% confidence level and significances are reported on the production cross section of new resonances as functions of their widths and masses, between 2 and 10 TeV. In particular, at a four-jet resonance mass of 8.6 TeV, the local (global) significance ranges from 3.9 (1.6) to 3.6 (1.4) standard deviations (s.d.) as the resonance width is increased from 1.5 to 10%. This relative insensitivity to the choice of width indicates that a broad resonance is an equally valid interpretation of this excess. The broad resonance hypothesis at a resonance mass of 8.6 TeV is supported by the presence of an event with a four-jet mass of 5.8 TeV and an average dijet mass of 2.0 TeV. Also, we report the reinterpretation of a second effect, at a four-jet resonance mass of 3.6 TeV, which has a local (global) significance of up to 3.9 (2.2) s.d.
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High Psychological Impact of Covid‐19 on French Healthcare Workers: An Observational Cohort Study of PTSD, Depression and Burn‐Out
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Wissam El-HageAlexandre LeméMyriam BlanchinEric BuiHala KerbageSarah IbouhsissenAude Allemang-TrivalleValérie GissotB.GohierCoraline HingrayPhilippe BirmesEric FakraNathalie PrietoCédric LemogneMarie‐odile KrebsBruno AouizerateIsabelle JalenquesPierre VidailhetAnne SauvagetAgnès Caille
High Psychological Impact of Covid‐19 on French Healthcare Workers: An Observational Cohort Study of PTSD, Depression and Burn‐Out
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Wissam El-HageAlexandre LeméMyriam BlanchinEric BuiHala KerbageSarah IbouhsissenAude Allemang-TrivalleValérie GissotB.GohierCoraline HingrayPhilippe BirmesEric FakraNathalie PrietoCédric LemogneMarie‐odile KrebsBruno AouizerateIsabelle JalenquesPierre VidailhetAnne SauvagetAgnès Caille
- Organismes : Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours MethodS in Patients-centered outcomes and HEalth ResEarch CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie Centre de recherche en épidémiologie et santé des populations Hôpital Saint Eloi [CHU Montpellier] Centre d’Investigation Clinique [Tours] CIC 1415 Centre d’Investigation Clinique [Tours] CIC 1415 Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Universitaire d'Angers SFR UA 4201 Confluences Centre Psychothérapique de Nancy [Laxou] Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes et d'Addictologie du Grand Nancy Toulouse NeuroImaging Center Université Jean Monnet - Saint-Étienne Hôpital Edouard Herriot [CHU - HCL] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Hôtel-Dieu [Paris] Institut de psychiatrie et neurosciences de Paris Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Institut Pascal Institut national polytechnique Clermont Auvergne CHU Clermont-Ferrand Université Clermont Auvergne Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique [Tours] CIC 1415 MethodS in Patients-centered outcomes and HEalth ResEarch
- Publié dans Health Expectations le 26/10/2020
Résumé :Introduction:The Covid-19 outbreak hit the world forcing public institutions to rethink their core functioning. Healthcare workers (HCWs) were particularly at risk for negative mental health outcomes, given their direct exposure to many pandemicrelated stressors. Our study aimed to assess the psychological outcomes of French HCWs during the Covid-19 pandemic, including PTSD, depression and burn-out. Methods: This study presents the baseline data of a large cohort study conducted during the pandemic. Participants were 849 French HCWs (mostly single women, working as nurses) assessed for PTSD with the PCL-5 (PTSD Checklist for DSM-5), for depression with the PHQ-9 (Patient Health Questionnaire), and for burn-out and compassion satisfaction with the ProQOL (Professional Quality of Life). Other pandemic-related variables were also collected, including characteristics related to participants' Covid-19 experience, as well as psychological and clinical measures.
Fichiers liés : Health Expectations - 2025 - El‐Hage - High Psychological Impact of Covid‐19 on French Healthcare Workers An Observational.pdf
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Efficacy and safety of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy versus Roux-en-Y gastric bypass in France (SADISLEEVE): results of a randomised, open-label, superiority trial at 2 years of follow-up
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Maud RobertTigran PoghosyanNicolas Romain-ScelleSebastien CzernichowDominique DelaunayAdrien SterkersLitavan KhamphommalaAndrea LazzatiClaire BlanchardRobert CaiazzoFrançois PattouEmmanuel DisseCaroline GronnierFabian RechePhilippe TopartJean-Louis LorinPhilippe RaffaitinNelson TrellesIole SicilianoLaurent BrunaudDaniel KrawczykowskiGéraud TuyerasAdriana TorciviaElise PelasciniBérénice SégrestinCarole Langlois-Jacques
Efficacy and safety of single-anastomosis duodeno-ileal bypass with sleeve gastrectomy versus Roux-en-Y gastric bypass in France (SADISLEEVE): results of a randomised, open-label, superiority trial at 2 years of follow-up
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Maud RobertTigran PoghosyanNicolas Romain-ScelleSebastien CzernichowDominique DelaunayAdrien SterkersLitavan KhamphommalaAndrea LazzatiClaire BlanchardRobert CaiazzoFrançois PattouEmmanuel DisseCaroline GronnierFabian RechePhilippe TopartJean-Louis LorinPhilippe RaffaitinNelson TrellesIole SicilianoLaurent BrunaudDaniel KrawczykowskiGéraud TuyerasAdriana TorciviaElise PelasciniBérénice SégrestinCarole Langlois-Jacques
- Organismes : Hospices Civils de Lyon Centre de recherche sur l'Inflammation Hospices Civils de Lyon Université Claude Bernard Lyon 1 Département biostatistiques et modélisation pour la santé et l'environnement [LBBE] Biostatistiques santé [LBBE] Service de Biostatistiques [Lyon] Hôpital Européen Georges Pompidou [APHP] Hospices Civils de Lyon Centre Hospitalier Privé Saint-Grégoire [Saint-Gregoire] Centre Hospitalier Privé Saint-Grégoire [Saint-Gregoire] Sciences de l’information au service de la médecine personnalisée Sciences de l’information au service de la médecine personnalisée Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Lyon Sud [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition French-Clinical Research Infrastructure Network / F-CRIN [Lyon] Université de Bordeaux Centre Hospitalier Alpes Isère [Grenoble, France] Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Toulouse Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon
- Publié dans The Lancet le 02/11/2020
Résumé : Abstract Background hPG 80 (circulating progastrin), initially recognized for its oncogenic properties due to its direct link to the Wnt signaling pathway, is secreted by cancer cells and detectable in the blood of cancer patients. The ONCOPRO centralized case-control study (NCT03787056) was designed to prospectively evaluate the diagnostic utility of hPG 80 in patients with 16 different types of cancer. Methods hPG 80 levels were measured in 421 patients with 16 newly diagnosed cancers (median age 65.6 years old) using the DxPG80.Lab kit (Biodena Care). The diagnostic performance of hPG 80 (the primary endpoint) was assessed by comparing baseline hPG 80 levels in cancer patients with those of 330 asymptomatic aged-matched healthy subjects from the general population. Results Between 2018 and 2022, a total of 506 cancer patients were enrolled in the study, with 421 assessable across 16 distinct cancer cohorts. hPG 80 concentrations were significantly higher in cancer patients compared to the healthy population (median 3.8 [IQR: 1.0-11.1] vs. 1.9 [IQR: 0.6–4.2] pM, P < 0.0001). hPG80 levels were not impacted by renal failure, liver dysfunction, or cancer-associated inflammation. The diagnostic accuracy in cancer patients was ROC AUC 0.63, 95% CI = [0.59–0.67]. The highest diagnostic accuracy was seen in patients with lung cancer (AUC 0.75, 95% CI [0.68–0.82]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old) and hepatocellular carcinoma HCC (ROC AUC 0.75, 95% CI [0.66-083]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old). Conclusions This large prospective study confirms that cancer patients have significantly higher hPG 80 blood concentration compared to the healthy population. Incorporating this straightforward ELISA assay into screening programs is warranted. Trial registration NCT03787056.
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Non-canonical internalization mechanisms of mGlu receptors
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Marta CimadevilaJunke LiuDamien MaurelIsabelle BrabetMarine HoscarJulia DrubeCarsten HoffmannAsuka InouePhilippe RondardPierre-André LafonLaurent PrézeauJean-Philippe Pin
Non-canonical internalization mechanisms of mGlu receptors
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Marta CimadevilaJunke LiuDamien MaurelIsabelle BrabetMarine HoscarJulia DrubeCarsten HoffmannAsuka InouePhilippe RondardPierre-André LafonLaurent PrézeauJean-Philippe Pin
- Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany] Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany] Tohoku University [Sendai] Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
- Publié dans Cell Reports le 30/10/2020
Résumé : Cell surface G protein-coupled receptors (GPCRs) are tightly regulated through constitutive and agonist-induced internalization. While the mechanisms of constitutive internalization remain elusive, agonist-induced internalization very often involves receptor phosphorylation by GPCR kinases (GRKs) and β-arrestin recruitment. Dimeric class C metabotropic glutamate (mGlu1-mGlu8) receptors regulate synaptic transmission, but their internalization process remains ambiguous. Here, using diffusion-enhanced energy transfer (DERET), we show that mGlu receptors undergo constitutive internalization that mostly relies on β-arrestins. However, only mGlu1, mGlu5, and mGlu3 homodimers and mGlu2-3 heterodimers undergo agonist-induced internalization. This process depends on protein adaptor complex 2 (AP2) but still occurs in the absence of GRKs or β-arrestins, with the latter acting as fine-tuners. This systematic study further highlights how class C receptors differ from other GPCRs, revealing non-canonical internalization mechanisms that remain to be characterized. These insights into mGlu receptor dynamics will contribute to the development of therapeutic strategies targeting mGlu receptors.
Fichiers liés : Cimadevila et al 2025.pdf
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Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Faiez ZannadChristopher M O'ConnorJaved ButlerCiaran J McmullanKevin J AnstromIrina BarashMarc P BonacaMaria BorentainStefano CordaDavis GatesJustin A EzekowitzAdrian F HernandezCarolyn S P LamEldrin F LewisJoann LindenfeldRobert J MentzPiotr PonikowskiYogesh N V ReddyGiuseppe M C RosanoClara SaldarriagaMichele SenniPedro P TeixeiraJames UdelsonAlessia UrbinatiVanja VlajnicAdriaan A VoorsAiwen XingMahesh J PatelPaul W ArmstrongBurkert PieskeJoerg KoglinLothar RoessigKris ReayLisa SoulardTracy TempleCynthia WesterhoutConstance HamlinRhonda LovettNicholas RyanRobert BlausteinGregory GolmGang JiaChristi KentJaco de KlerkChristina SalernoSabine Broeker-ZweeringRichard NkulikiyinkaElaine WuKatharina MuellerElisabeth Pieske-KraigherMartin KropfRaymond J KimMichele ParkerSebastian KelleJeanette Schulz-MengerChristopher DefilippiRachel BellPalak ShahPeter ShawMichael LassmanFrank KramerRobert ChristensonDaniel MarkLinda Davidson-RayM. Cecilia BahitDavid M KayeDiana BondermanAnne-Catherine PouleurEdimar A BocchiFernando LanasJian ZhangVojtěch MelenovskýJens RefsgaardJohan LassusAlain Cohen-SolalFrank EdelmannDimitrios N TziakasJuan Luis Arango BeneckeDavid SiuEbrahim NooriKenneth McdonaldBasil S LewisMichele EmdinHiroyuki TsutsuiImran Zainal AbidinJorge EscobedoArend MosterdRichard W TroughtonDan AtarArmando Lionel Godoy PalominoEugenio B ReyesJose B Vazquez-TanusMyeong-Chan ChoYury LopatinDavid SimKaren Sliwa-HähnleJosé López-SendónLars H LundChern-En ChiangM. Ali OtoMartin CowieMichael M GivertzIleana L PiñaNancy K. SweitzerJohn J.V. McMurrayChristopher B GrangerThomas D CookGary S FrancisKarl SwedbergHaley HedlinG. Michael FelkerW. Schuyler JonesKaren P AlexanderSana M Al-KhatibKeith E DombrowskiRobert W HarrisonRenato D LopesRobin MathewsThomas J PovsicMatthew T RoeSreekanth VemulapalliEduardo Roque PernaMaria Galarza SalazanIgnacio MackinnonFlorencia EdenLuis CartasegnaViviana NovasHugo A LuquezAna CenciMiguel Angel HominalMaria Veronica BianchiniRodolfo Andres Ahuad GuerreroAndrea Alvarez D AmelioCarlos Alberto PoyMaria PoyClaudio R MajulCecilia CurraoEzequiel Hector VotteroMariana PerrinCesar Javier ZaidmanMaria Vanesa EspinosaGerardo ZapataLuciana AriasSonia Angelica SassoneLucas TonelliDaniel Agustin Chirino NavartaMaria ManginiJesus CuadradoPaula BordoniDavid M KayeKaye CarterJohn AmerenaToni ShanahanScott MckenzieKathryn StibijlCarmine de PasqualeFiona WollastonDavid Martin ColquhounAntonio Ferreira-JardimAlicia ChanGreer DymmottBrendan McquillanKatayun MohammadiDavid CrossJudy JeffreyAndrew SindoneMagdalena GebranAmit ShahGill TullochMaged WilliamBets ConwayJames WongDonna NorthDirk von LewinskiKarin BrandnerUta HoppeKristen KoppRegina Steringer MascherbauerClaudia SteinkellnerChristina BinderChristopher AdlbrechtMaria LeitgebFlorence SinnaeveMatthias DupontCarola ClaesMichel de CeuninckEls VancayseelePhilippe TimmermansGregory van GenechtenPierre TroisfontainesMireille MassozThao Thanh HuynhCaroline BoudreaultEric SabbahIsabelle ChausseRonald Leonard BourgeoisKaren BoydMichael HeffernanMarie BirchMarie-Claude ParentHelene BrownA. Shekhar PandeyTatiana BallivianNadia GiannettiReza SahebjameiSaul VizelBeverley FoxDennis Wayne RupkaSandi ThiessenChristian ConstanceMarie-France GauthierQuentin KushnerikAllan SchafferWendy JanzMichael ChanJennifer KnightSerge LepageDaniel SoucyJohn D ParkerElaine HsuLisa MielniczukErmina MogaBenoit CoutuJulie FleuryPaul MacdonaldKathleen HinesDiego DelgadoNatalia NugaevaYing SiaIsabelle RoyDavid LaflammeChristel SimardGilbert GosselinKatia DrouinBrian ClarkeKimberley RonakDenis SaulnierMelissa CoteBruce Alexander SussexBernadette DrukenMiroslaw RajdaJayne FalkenhamAshok MukherjeeBeverly BozekGordon Willy Pak Ling MoeCarlos FernandoSebastien BergeronHugo TremblayMarcelo Coelho ShibataBonnie WoloschukDante ManyariTracy ClevelandFrank NigroCrystal ForsythAnnie RoyHelene BolducDanielle DionNancy GilbertJames Y ChaJudy OtisMelinda BarabasMarie-Josee ChartrandVictor AssefAndrea EikhofManuel Novajas BalboaCarla Belen Aravena VasquezJuan Carlos Prieto DominguezViviana NoriegaPatricio 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BroadheadLisa AndersonJoanna BrownJustin CookeMichelle KinninChristopher CassidyFrancis GaleraAndrew MoriartyAbeesh PanickerIfy MordiLisa MellishManish SaxenaSusan CrawfordPrithwish BanerjeeRosemary HarperMatthew DewhurstDeborah JonesMadhusudhan VarmaBen JonesBassem IbrahimRebecca CuttsAaron WongAngela DoughtyRumi JaumdallySusan ReganPatrick MooreLani HolmanDavid WilsonCynthia LarewPatrick DonnellyHaydee GutierrezMohsin AlhaddadPhillippa Mccartney MoralesLinda CadaretJorge AllinaMehrdad ArianiSajad HamalRasha YoussefMaite RamirezDavid BernardMadeline PeekMatthew BudoffKelli CloppJose F CardonaJaime WyattJames FeldmanStephanie LambertFerris GeorgeBeatriz PenafielEve GillespieMarie RenoObinna IsiguzoLinda SchwarzLuis MartinezRose HroncichUsman QayyumDonna WinterrowdRenee SangrigoliSabrina ForbusMarcus L WilliamsKevin ThorntonRavi BhagwatCrystal DuboisBrian FoleyHeather MaschenikAshish GangasaniMoravia VasalloNaseem JaffraniAnne DirksFelix SogadeLauren StamschrorJavier VasalloLeigha 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DharmaShelli RobertsWilliam HerzogLynett ZacharyIyad IssehLoren MooreChristopher DanielsKimberly ArmstrongLars RunquistSvetlana StrugatskyGhiyath TabbalNehal VekariyaAndre ArtisRamona StevensFreny ModyIbraheem AlajlouniPankaj AroraPeter OsmondMahfouz El ShahawyYasmire EvansGhiath MikdadiNadine KallasJoseph IzzoIluyomade AdeusiAnu Lala-TrindadeLisa EnglishBrian BostickAnastasiia PiskunAlexandra CornellConstance HamlinKatie LamontMartina ZilliChristi KentJaco de KlerkChristina SalernoLydia ChristopherScott MckenzieFabiana MarcondesShelley ZierothAnique DucharmeJunbo GeJuan Esteban GómezStefan StoerkGerasimos FilippatosPablo MontenegroAlex LeeKen McdonaldMarco MetraImran AbidinFelix Alvaro MedinaDavid SimKaren SliwaMarisa LeiroYüksel CavusogluPalak ShahBarry GreenbergTom D CookAldo MaggioniKarl SwedbergJane E WilcoxMaria Rosa CostanzoHaley HedlinW. Schuyler JonesKaren P AlexanderSana M Al-KhatibJorge GutierrezRobert W HarrisonMark KittipibulBradley KollsDavid KongJoseph LermanRobert MatthewsRobert McgarrahRajendra MehtaThomas J PovsicJennifer RymerCina Sasannejad
Vericiguat for patients with heart failure and reduced ejection fraction across the risk spectrum: an individual participant data analysis of the VICTORIA and VICTOR trials
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Faiez ZannadChristopher M O'ConnorJaved ButlerCiaran J McmullanKevin J AnstromIrina BarashMarc P BonacaMaria BorentainStefano CordaDavis GatesJustin A EzekowitzAdrian F HernandezCarolyn S P LamEldrin F LewisJoann LindenfeldRobert J MentzPiotr PonikowskiYogesh N V ReddyGiuseppe M C RosanoClara SaldarriagaMichele SenniPedro P TeixeiraJames UdelsonAlessia UrbinatiVanja VlajnicAdriaan A VoorsAiwen XingMahesh J PatelPaul W ArmstrongBurkert PieskeJoerg KoglinLothar RoessigKris ReayLisa SoulardTracy TempleCynthia WesterhoutConstance HamlinRhonda LovettNicholas RyanRobert BlausteinGregory GolmGang JiaChristi KentJaco de KlerkChristina SalernoSabine Broeker-ZweeringRichard NkulikiyinkaElaine WuKatharina MuellerElisabeth Pieske-KraigherMartin KropfRaymond J KimMichele ParkerSebastian KelleJeanette Schulz-MengerChristopher DefilippiRachel BellPalak ShahPeter ShawMichael LassmanFrank KramerRobert ChristensonDaniel MarkLinda Davidson-RayM. Cecilia BahitDavid M KayeDiana BondermanAnne-Catherine PouleurEdimar A BocchiFernando LanasJian ZhangVojtěch MelenovskýJens RefsgaardJohan LassusAlain Cohen-SolalFrank EdelmannDimitrios N TziakasJuan Luis Arango BeneckeDavid SiuEbrahim NooriKenneth McdonaldBasil S LewisMichele EmdinHiroyuki TsutsuiImran Zainal AbidinJorge EscobedoArend MosterdRichard W TroughtonDan AtarArmando Lionel Godoy PalominoEugenio B ReyesJose B Vazquez-TanusMyeong-Chan ChoYury LopatinDavid SimKaren Sliwa-HähnleJosé López-SendónLars H LundChern-En ChiangM. Ali OtoMartin CowieMichael M GivertzIleana L PiñaNancy K. SweitzerJohn J.V. McMurrayChristopher B GrangerThomas D CookGary S FrancisKarl SwedbergHaley HedlinG. Michael FelkerW. Schuyler JonesKaren P AlexanderSana M Al-KhatibKeith E DombrowskiRobert W HarrisonRenato D LopesRobin MathewsThomas J PovsicMatthew T RoeSreekanth VemulapalliEduardo Roque PernaMaria Galarza SalazanIgnacio MackinnonFlorencia EdenLuis CartasegnaViviana NovasHugo A LuquezAna CenciMiguel Angel HominalMaria Veronica BianchiniRodolfo Andres Ahuad GuerreroAndrea Alvarez D AmelioCarlos Alberto PoyMaria PoyClaudio R MajulCecilia CurraoEzequiel Hector VotteroMariana PerrinCesar Javier ZaidmanMaria Vanesa EspinosaGerardo ZapataLuciana AriasSonia Angelica SassoneLucas TonelliDaniel Agustin Chirino NavartaMaria ManginiJesus CuadradoPaula BordoniDavid M KayeKaye CarterJohn AmerenaToni ShanahanScott MckenzieKathryn StibijlCarmine de PasqualeFiona WollastonDavid Martin ColquhounAntonio Ferreira-JardimAlicia ChanGreer DymmottBrendan McquillanKatayun MohammadiDavid CrossJudy JeffreyAndrew SindoneMagdalena GebranAmit ShahGill TullochMaged WilliamBets ConwayJames WongDonna NorthDirk von LewinskiKarin BrandnerUta HoppeKristen KoppRegina Steringer MascherbauerClaudia SteinkellnerChristina BinderChristopher AdlbrechtMaria LeitgebFlorence SinnaeveMatthias DupontCarola ClaesMichel de CeuninckEls VancayseelePhilippe TimmermansGregory van GenechtenPierre TroisfontainesMireille MassozThao Thanh HuynhCaroline BoudreaultEric SabbahIsabelle ChausseRonald Leonard BourgeoisKaren BoydMichael HeffernanMarie BirchMarie-Claude ParentHelene BrownA. Shekhar PandeyTatiana BallivianNadia GiannettiReza SahebjameiSaul VizelBeverley FoxDennis Wayne RupkaSandi ThiessenChristian ConstanceMarie-France GauthierQuentin KushnerikAllan SchafferWendy JanzMichael ChanJennifer KnightSerge LepageDaniel SoucyJohn D ParkerElaine HsuLisa MielniczukErmina MogaBenoit CoutuJulie FleuryPaul MacdonaldKathleen HinesDiego DelgadoNatalia NugaevaYing SiaIsabelle RoyDavid LaflammeChristel SimardGilbert GosselinKatia DrouinBrian ClarkeKimberley RonakDenis SaulnierMelissa CoteBruce Alexander SussexBernadette DrukenMiroslaw RajdaJayne FalkenhamAshok MukherjeeBeverly BozekGordon Willy Pak Ling MoeCarlos FernandoSebastien BergeronHugo TremblayMarcelo Coelho ShibataBonnie WoloschukDante ManyariTracy ClevelandFrank NigroCrystal ForsythAnnie RoyHelene BolducDanielle DionNancy GilbertJames Y ChaJudy OtisMelinda BarabasMarie-Josee ChartrandVictor AssefAndrea EikhofManuel Novajas BalboaCarla Belen Aravena VasquezJuan Carlos Prieto DominguezViviana NoriegaPatricio YovaninizMarcela GrandonJessica HidalgoYuhui ZhangJing DongHaiying DaiYing XiaoTingbo JiangLin ShiJiyan ChenPeiyu HeDaoquan PengFangmei QingBiao XuRuihong WangXiang GuMin WangZhuhua YaoYing ChenPeizhi MiaoZhenfei ChenHui LiDongyan HuangQing YangXuefang YuAidong ShenXin ZhangXiaohui LiuQiang LvYugang DongDan LiuJingfeng WangHuijun OuyangChengchun TangYong ChenHui GongDandan TengJing YanLinying XuWeihong JiangXiaowei ZhouGuosheng FuYing ZhengShuyang ZhangLihong XuZhenyu YangChenying WuXiumin HanYuxia WangJing YuQiongying WangLihong WangLili ZhengWei JinNan ZhangChuanhuan ZhangXiaojian SunYali YaoPeng LeiZhaofen ZhengJunkui WangFengling MaMingzhi LongSulan WangHong ZhangMingmei GuoManhua ChenYayun WangZhanquan LiRuili DuanZuyi YuanTiaotiao LiYibin MeiLinyan YeZhouqing HuangXingyuan ZhangWenling LiuLei LiRuiping ZhaoJie GongDongqing ZhangJiahui ZhuChengjian YangChunxia WangZheng JiGao XinpeiXia MeiMingyun LiuPaula Garcia AmayaWilder Castano OsorioMaria DussanFranklin Roberto Quiroz DiazYuleth PradaCarlos Francisco Jaramillo MunozAna ZapataMonica JaramilloSolmara BelloRodrigo BoteroSandra SalazarMonica Lopez ParejaClaudia MoraNicolas Ignacio Jaramillo GomezJuan Camilo GarciaFabian TorresMiguel Alfredo MoncadaLaura Velez GilJaime Andres TorresYolanda LievanoVojtěch MelenovskýMiroslava KrausovaJan MalikMartin HajslKaterina MalaJan F VojacekJana FridrichovaFilip MalekDana RihovaVladimir CechLenka MasarikovaVilma MachovaJindrich SpinarJan MachaLibor NechvatalKenneth EgstrupLene MoltrupBenedikte HaastrupCamilla JespersenOle NyvadLene TanggaardLars FogPauline JohansenHenrik WiggersKristine Serup-HansenJens Due LomholdtKari NiemannOlav Wendelboe NielsenElisa StokholmMustafa TaskiranLotte Ring PedersenKai NymanTiina SankariHeikki UkkonenTuija VasankariSari KaresvuoriMiguel Vazquez IbarraKarim GalloujAngelique LombartThibaud DamyMounira KarhoubiMichel GalinierNathalie RosoliGuillaume TaldirMaelle VomscheidJean-Michel TartiereCharline GeninMuriel SalvatDelphine 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SahinHakan AltayFatma Nur ErtuncErsel OnratGizem Celik EminogluCihan AltinEsmanur MizrakTayfun SahinBulut AkbulutErgun Baris KayaEzgi AslanHasan BarmanBerna AkinVineet VenugopalIulia VolchykThomas Duythuc ToTaras ChendeyOleksandr KulbachukMishka PavelkoRoman StetsOlena BeregovaMykola RishkoOksana PysankoAndriy YagenskyYaroslav LutaiLeonid RudenkoGanna RudyaDmytro ReshotkoAndriy YurkivOleksandr ParkhomenkoOksana GliebovaLarysa MishchenkoDiana SchyhypakOlena LevchenkoHalyna HavryliukOleksandr ProkhorovOksana BilonkoOleksandra DonetsAlla DzybaHalyna MyshanychOlha RadchenkoSergii ShevchukAndrii DanyliukIvan VyshnyvetskyyTetiana DankoVira TseluykoTaras PetrovskyyAndrii KlantsaVolodymyra SovtusAnna KulykTetiana ShandraRoman PetrovskyyElena RomanovaIgor VakaliukDenys BabichevSvitlana ZhurbaGanna KrotenkoOleg SychovNataliia KumpanIurii RudykSvitlana TrubinaOzlem YildirimturkSandra ElphickAhmet GencAlexandra FlorouAhmet FuatRita AdregoCraig Scott BarrSinead LyonsTheresa McdonaghSarah BroadheadLisa AndersonJoanna BrownJustin CookeMichelle KinninChristopher CassidyFrancis GaleraAndrew MoriartyAbeesh PanickerIfy MordiLisa MellishManish SaxenaSusan CrawfordPrithwish BanerjeeRosemary HarperMatthew DewhurstDeborah JonesMadhusudhan VarmaBen JonesBassem IbrahimRebecca CuttsAaron WongAngela DoughtyRumi JaumdallySusan ReganPatrick MooreLani HolmanDavid WilsonCynthia LarewPatrick DonnellyHaydee GutierrezMohsin AlhaddadPhillippa Mccartney MoralesLinda CadaretJorge AllinaMehrdad ArianiSajad HamalRasha YoussefMaite RamirezDavid BernardMadeline PeekMatthew BudoffKelli CloppJose F CardonaJaime WyattJames FeldmanStephanie LambertFerris GeorgeBeatriz PenafielEve GillespieMarie RenoObinna IsiguzoLinda SchwarzLuis MartinezRose HroncichUsman QayyumDonna WinterrowdRenee SangrigoliSabrina ForbusMarcus L WilliamsKevin ThorntonRavi BhagwatCrystal DuboisBrian FoleyHeather MaschenikAshish GangasaniMoravia VasalloNaseem JaffraniAnne DirksFelix SogadeLauren StamschrorJavier VasalloLeigha HughesGregory Alan EwaldMohamed KhalilMajdi AshchiNancy FrySandeep KhoslaHeather BlubaughHahn BuiSmelda FerrinJohn McgintyRafael MuroJesse DoranAbeer Abu-SaifDennis SpillerJennifer BajornasHamid TaheriMarisol RamosImad HaririAlicia PhillipsAtaul QureshiJill SchulteNarendra SinghVicky ParfaitAndrea PhillipsMalcolm LustJuliane ViereckeMargie MckercherPeter S FailJacqueline KillianRobert LongVictoria SmithRamon LloretRema IskandaraniNabil DibBreanna CulverSiby AyallooreAli MuhammadKatherine MichelisStephanie AlfordFahed BitarAmy KingLokesh ChandraRichard JacksonVijay RaoHailey JenkinsDavid HotchkissYulia AbidovRichard JacksonAriel QuebedeauxMatthew JanikSharyce Hayes-JonesMarcel E ZughaibTeresa OsmulskiWade MayNatalie FialloDilip B ViswanathEmily GilderAlexander AdlerAmanda ReynoldsJoshua LarnedAshley WilliamsJoseph SurberApril HowarterMark NapoliRobert EdmondWayne OldAlison SolomonChristopher SparrowMihret AssefaDivya GuptaNicole ScottGlenn HamroffSirisha TirumanisettiChrisette DharmaShelli RobertsWilliam HerzogLynett ZacharyIyad IssehLoren MooreChristopher DanielsKimberly ArmstrongLars RunquistSvetlana StrugatskyGhiyath TabbalNehal VekariyaAndre ArtisRamona StevensFreny ModyIbraheem AlajlouniPankaj AroraPeter OsmondMahfouz El ShahawyYasmire EvansGhiath MikdadiNadine KallasJoseph IzzoIluyomade AdeusiAnu Lala-TrindadeLisa EnglishBrian BostickAnastasiia PiskunAlexandra CornellConstance HamlinKatie LamontMartina ZilliChristi KentJaco de KlerkChristina SalernoLydia ChristopherScott MckenzieFabiana MarcondesShelley ZierothAnique DucharmeJunbo GeJuan Esteban GómezStefan StoerkGerasimos FilippatosPablo MontenegroAlex LeeKen McdonaldMarco MetraImran AbidinFelix Alvaro MedinaDavid SimKaren SliwaMarisa LeiroYüksel CavusogluPalak ShahBarry GreenbergTom D CookAldo MaggioniKarl SwedbergJane E WilcoxMaria Rosa CostanzoHaley HedlinW. Schuyler JonesKaren P AlexanderSana M Al-KhatibJorge GutierrezRobert W HarrisonMark KittipibulBradley KollsDavid KongJoseph LermanRobert MatthewsRobert McgarrahRajendra MehtaThomas J PovsicJennifer RymerCina Sasannejad
- Organismes : Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Inova Heart and Vascular Institute [Falls Church, VA, USA] Baylor Scott and White Research Institute [Dallas, TX, USA] University of Southern Mississippi Merck Sharp and Dohme Université de Caroline du Nord à Chapel Hill = University of North Carolina [Chapel Hill] Merck Sharp and Dohme University of Colorado [Colorado Springs] Bayer, Research & Development, Pharmaceuticals Bayer HealthCare Pharmaceuticals, Inc. [Basel, Switzerland] Pharmaceutical Sciences, Merck & Co. Inc. University of Alberta Duke Clinical Research Institute National Heart Centre Singapore Duke-National University of Singapore Graduate Medical School Stanford School of Medicine [Stanford] Vanderbilt University Medical Center [Nashville] Duke University Medical Center Wrocław Medical University Mayo Clinic [Rochester] Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele [Roma] San Raffaele Open University of Rome Universidad Pontificia Bolivariana Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Hospital Papa Giovanni XXIII Università degli Studi di Milano-Bicocca = University of Milano-Bicocca Technische Universität Munchen - Technical University Munich - Université Technique de Munich Bayer AG [Germany] Tufts Medical Center [Boston] Merck Sharp and Dohme Bayer U.S., LLC, Whippany, NJ. University Medical Center Groningen [Groningen] Pharmaceutical Sciences, Merck & Co. Inc. BAIF Institute for Sustainable Livelihoods and Development, Gujarat, India. Merck Sharp and Dohme University of Alberta Charité - UniversitätsMedizin = Berlin University Medicine German Center for Cardiovascular Research German Heart Center Berlin Merck Research Laboratories Bayer AG [Germany] Institut photonique d'analyse non-destructive européen des matériaux anciens Laboratoire de Linguistique de Nantes Excelia Group | La Rochelle Business School Transitions Energétiques et Environnementales Centre National de la Recherche Scientifique
- Publié dans The Lancet le 02/11/2020
Résumé :Background Following completion of the VICTORIA trial, vericiguat was approved for the treatment of worsening heart failure with reduced ejection fraction (HFrEF) and received a class IIb recommendation in European and North American guidelines. The subsequent VICTOR trial evaluated the use of vericiguat in patients with HFrEF and no recent worsening. We aimed to assess the effect of vericiguat on clinical endpoints through pooled analyses of patientlevel data from the VICTORIA and VICTOR trials. Methods This prespecified, pooled individual participant-level analysis was conducted on data from two trials: VICTORIA, which was active from Sept 25, 2016, to Sept 2, 2019 in 42 countries, and VICTOR, which was active from Nov 2, 2021, to Feb 5, 2025 in 36 countries. The VICTORIA trial enrolled adult (aged ≥18 years) participants with HFrEF with recent worsening (defined as either hospitalisation for heart failure within the previous 6 months or outpatient use of intravenous diuretics within the previous 3 months) and increased NT-proBNP concentrations; the VICTOR trial had similar eligibility criteria but participants had no recent worsening of heart failure. Participants in both trials received contemporary background guideline-directed heart failure therapy as appropriate. The primary endpoint was a composite endpoint of cardiovascular death or hospitalisation for heart failure (also assessed individually). This study is registered with PROSPERO, CRD420251065636. Findings Data from 11 155 patients (5050 in the VICTORIA trial and 6105 in the VICTOR trial) were included in the pooled analysis. The primary endpoint of cardiovascular death or hospitalisation for heart failure occurred in 1446 (25•9%) of 5579 patients in the vericiguat group and 1556 (27•9%) of 5576 patients in the placebo group (hazard ratio [HR] 0•91 [95% CI 0•85-0•98]; p=0•0088), with similar reductions in its individual components of cardiovascular death (0•89 [0•80-0•98]; p=0•020) and hospitalisation for heart failure (0•92 [0•84-1•00]; p=0•043) as first events. Interpretation Vericiguat reduced the risk of hospitalisation for heart failure and cardiovascular death in patients with HFrEF across a broad range of clinical severity, including those receiving contemporary guideline-directed medical therapy. Vericiguat might be suitable as an additional treatment option for selected patients with HFrEF. Funding Merck Sharp & Dohme (a subsidiary of Merck) and Bayer.
Fichiers liés : 1-s2.0-S0140673625016824-main.pdf
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Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Antoine GavoilleEmmanuelle LerayRomain MarignierFabien RollotRomain CaseyGuillaume MatheyLaure MichelJérôme de SèzeJonathan CironAurélie RuetElisabeth MaillartPierre M LabaugeHélène ZéphirDavid-Axel LaplaudCaroline PapeixGilles-Louis DeferThibault MoreauEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagyJean-Philippe CamdessanchéInès DoghriSolène MoulinCéline LabeyrieKarolina HankiewiczAmélie dos SantosCorinne PottierÉric ManchonMaya TchikviladzeChristine Lebrun-FrénaySandra VukusicLucie Bellon-TabartDelphine CortialFrançois CottonF. GuilleminJavier OlaizBruno StankoffEmmanuelle Le PageNicolas CollonguesArnaud KwiatkowskiSandrine WiertlewskiClaire GiannesiniBertrand AudoinPhilippe CabrePierre DurozardBertrand LapergueChantal NifleJérôme Grimaud
Sex-Related Gap in the Use of Disease-Modifying Therapies in Multiple Sclerosis
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Antoine GavoilleEmmanuelle LerayRomain MarignierFabien RollotRomain CaseyGuillaume MatheyLaure MichelJérôme de SèzeJonathan CironAurélie RuetElisabeth MaillartPierre M LabaugeHélène ZéphirDavid-Axel LaplaudCaroline PapeixGilles-Louis DeferThibault MoreauEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagyJean-Philippe CamdessanchéInès DoghriSolène MoulinCéline LabeyrieKarolina HankiewiczAmélie dos SantosCorinne PottierÉric ManchonMaya TchikviladzeChristine Lebrun-FrénaySandra VukusicLucie Bellon-TabartDelphine CortialFrançois CottonF. GuilleminJavier OlaizBruno StankoffEmmanuelle Le PageNicolas CollonguesArnaud KwiatkowskiSandrine WiertlewskiClaire GiannesiniBertrand AudoinPhilippe CabrePierre DurozardBertrand LapergueChantal NifleJérôme Grimaud
- Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon École des Hautes Études en Santé Publique [EHESP] Recherche sur les services et le management en santé Arènes: politique, santé publique, environnement, médias Département Méthodes quantitatives en santé publique Université de Rennes Hospices Civils de Lyon Université Claude Bernard Lyon 1 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Service de Neurologie [Rennes] = Neurology [Rennes] Centre d'Investigation Clinique [Rennes] CIC Strasbourg Service de Neurologie [Strasbourg] Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut Toulousain des Maladies Infectieuses et Inflammatoires Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale CHU Pitié-Salpêtrière [AP-HP] CHU Montpellier = Montpellier University Hospital Université de Montpellier Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology CIC Plurithématique de Nantes Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université de Caen Normandie Service de Neurologie [CHU Caen] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de Neurologie [CHRU Besançon] CHU Pitié-Salpêtrière [AP-HP] Neuro-Dol Service Neurologie [CHU Clermont-Ferrand] Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de Neurologie [CHU de Saint-Étienne] Hôpital Bretonneau Service de neurologie [Reims] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] Service de neurologie [CHU de Poitiers] Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hospices Civils de Lyon Université Claude Bernard Lyon 1 Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS
- Publié dans Neurology le 01/11/2020
Résumé : Background and objectives: In women with multiple sclerosis (MS), the therapeutic strategy may be influenced by the anticipation of future pregnancies, leading to underexposure to disease-modifying therapies (DMTs) and highly effective DMTs (HEDMTs) compared with men. We aimed to evaluate potential therapeutic inertia in women with MS and explore its causes. Methods: We performed a retrospective cohort study based on data extracted on June 2023 from the Observatoire Français de la Sclérose en Plaques for all patients with a relapsing-remitting MS onset between 18 and 40 years. The primary outcome was the annual probability of receiving a DMT, accounting for sex, disease severity, and pregnancy/postpartum periods. Secondary outcomes were the annual probability of receiving a HEDMT, each DMT separately, and interaction of the effect of sex with calendar year, patient age, and disease duration. We used a longitudinal logistic model with generalized estimating equations and an inverse-probability-of-censoring weighting. Results: We included 22,657 patients with MS; 16,857 (74.4%) were female, mean (SD) age at onset was 29.0 (6.0) years, and median (interquartile range) follow-up duration was 11.6 (6.6-17.3) years. Women were significantly less likely to receive a DMT (odds ratio [OR] 0.92, 95% CI 0.87-0.97) or a HEDMT (OR 0.80, 95% CI 0.74-0.86). This difference appeared 2 years after disease onset for DMTs and 1 year for HEDMTs, and did not differ significantly according to patient's age. Teriflunomide, sphingosine-1-phosphate receptor modulators, and anti-CD20s were significantly underused in women throughout their entire period of availability; interferons β (IFN-β) and natalizumab were initially less used and then equally after some time; glatiramer acetate and fumarates were first used equally, then more frequently in women. The proportion of treated women, analyzed from the first childbirth of 5,268 women, began to decline 18 months before childbirth, from 42.6% to 27.9% at the estimated time of conception. Discussion: Women with MS were significantly less exposed to DMTs compared with men. Anticipation of pregnancy was probably an important factor underlying this difference, but also sex-specific therapeutic inertia. Neurologists and patients should be educated on the most recent recommendations on the use of DMTs in the context of pregnancy to avoid deleterious therapeutic inertia.
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Pro-inflammatory processes and metabolic syndrome: combined risk of resistance to treatment in patients with schizophrenia from the FACE-SZ cohort
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Kaori SaitohMohamed LajnefWahid BoukouaciMyrtille AndreChristelle AndrieuBruno AouizerateCaroline BarauJihène BouassidaDelphine CapdevielleIsabelle ChereauJulie Clauss-KobayashiNathalie CoulonJean-Michel DoreyCaroline DubertretEric FakraGuillaume FondTudi GozéP. Le CorvoisierSylvain LeignierPierre-Michel LlorcaJasmina MalletDavid MisdrahiNicolas OriolBaptiste PignonRomain ReyPaul RouxFranck SchürhoffBenoit SchorrMathieu UrbachEtienne VeryChing-Lien WuMarion LeboyerOphélia GodinRyad Tamouza
Pro-inflammatory processes and metabolic syndrome: combined risk of resistance to treatment in patients with schizophrenia from the FACE-SZ cohort
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Kaori SaitohMohamed LajnefWahid BoukouaciMyrtille AndreChristelle AndrieuBruno AouizerateCaroline BarauJihène BouassidaDelphine CapdevielleIsabelle ChereauJulie Clauss-KobayashiNathalie CoulonJean-Michel DoreyCaroline DubertretEric FakraGuillaume FondTudi GozéP. Le CorvoisierSylvain LeignierPierre-Michel LlorcaJasmina MalletDavid MisdrahiNicolas OriolBaptiste PignonRomain ReyPaul RouxFranck SchürhoffBenoit SchorrMathieu UrbachEtienne VeryChing-Lien WuMarion LeboyerOphélia GodinRyad Tamouza
- Organismes : IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Pôle de Psychiatrie [Hôpital Henri Mondor] Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Plateforme de Ressources Biologiques [Henri Mondor AP-HP, Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Institut Pascal Fondation FondaMental [Créteil] Centre Hospitalier Universitaire [Strasbourg] Sociétés, acteurs, gouvernement en Europe Institut d'Électronique et des Technologies du numéRique Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Université Sorbonne Paris Cité Psychiatric Disorders, Neuroscience Research and Clinical Research Université Jean Monnet - Saint-Étienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Fondation FondaMental [Créteil] Centre d'études et de recherche sur les services de santé et la qualité de vie Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Service Psychiatrie, Psychothérapies et Art-thérapie [CHU Toulouse] Institut National de la Santé et de la Recherche Médicale Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Association française de psychiatrie biologique et neuropsychopharmacologie = French Society for Biological Psychiatry and Neuropsychopharmacology Fondation FondaMental [Créteil] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Université de Bordeaux Centre National de la Recherche Scientifique Fondation FondaMental [Créteil]
- Publié dans Psychiatry Research le 25/10/2020
Résumé : Schizophrenia (SZ) is characterized by a variable clinical expression and course peppered/hampered by severe complications. In particular, resistance to treatment (overall-TRS, treatment resistant SZ including UTRS, ultra-TRS) and metabolic syndrome (MetS) are highly prevalent, and both demonstrated to be underpinned, at least partly, by pro-inflammatory processes. Given that such processes also underlie SZ per se , we hypothesized that potential inter-twinning between SZ-and MetS-related inflammatory processes may exert a combined effect on the risk of having overall-TRS/UTRS. A total of 419 outpatients with SZ underwent clinical assessments and blood sample collection. Using the values of circulating levels of eleven cytokines, we built a ratio between pro-and anti-inflammatory components respectively corresponding to the immunoinflammatory response system (IRS) and the compensatory immunoregulatory reflex system (CIRS) which overall reflect the underlying in-flammatory status. Such ratios allowed to categorize the patients according to Inflammation and MetS on four categories as follow: symbolscript symbolscript symbolscript and Inflam-mation(-)MetS(-). Multivariate logistic regression analysis showed that the combination of inflammation and MetS modulate the risk of having the overall-TRS symbolscript symbolscript 95 %CI [1.04-5.00], p symbolscript 0.039 and symbolscript symbolscript 95 % CI [1.76-11.97], p symbolscript 0.002 overall in comparison to Inflammation(-)MetS(-)]. Moreover, we observed that individuals with UTRS are those associated with both inflammation and/or MetS. Our results demonstrated the potential combined effect of MetS and inflammation towards resistance to treatment. Given that overall-TRS/UTRS are unpredictable while both inflammation and MetS can be early detected and managed, our findings shed new light on the possibility to better prevent treatment resistance in SZ.
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Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Jason RosadoAbebe FolaSandrine CojeanVéronique SarrasinRomain CoppéeJustine BaillyRizwana ZaffaroulahAzza BouzayeneLiliane CicéronLudivine HouzéRebecca CrudaleLise MussetMarc ThellierBruno PradinesJérôme ClainJeffrey BaileySandrine HouzéAhmed AboubacarPatrice AgnameyAbou-Bacar AhmedDaniel AjzenbergAdela AngoulvantFrédéric ArieyBenjamin AubryFirouze BanisadrSorya BelazGhania BelkadiGhania Belkacem BelkadiAnne Pauline BellangerDieudonné BembaFarida BenaoudiaMartine BlochFrancoise BotterelVincent BoudenMarie-Elisabeth BougnouxCaren BrumpSophie BrunJulie BrunetBernadette BuretPauline Caraux-PazNourrisson CelineSylvain ClauserElodie CollinNaima DahaneCéline DamianiEric DannaouiCéline DardMarie-Laure DardeAnne DebourgogneThierry DelacourJean-Marie DelarbreAnne DelavalVeronique DelceyAnne-Sophie DeleplancqueGuillaume DesoubeauxNathalie DesuremainGisele DewulfRémy DurandMarie-Fleur DurieuxEmmanuel DutoitOdile EloyJean-François FaucherLoïc FavennecAlbert FayeOdile FenneteauCécile FickoEmilie FrealleGilles GargalaCéline GarnaudLudovic De GentileNadine GodineauJudith GorlickiYohann Le GovicAlain GravetNadia GuennouniSamia HamaneThomas HanslikAntoine HugueninJean-Pierre HurstFakhri JeddiLeroy JordanLuce LandraudHélène LapillonneSébastien LarréchéRose-Anne LavergneJean Philippe LemoineCécile LeprinceElodie LestevenAngèle LiCaroline LohmannBasmaciyan LouiseMarie-Claire MachouartCéline MalassigneAnthony MarteauDanièle MaubonEdith MazarsBruno MégarbaneAna Mendes-MoreiraSylvain MermondGwénaël Le MoalAlicia MorenoPierre MornandJean-Benjamin MuratRené NabiasJerome NaudinGilles NevezCéline NourrissonMouri OussamaNathalie ParezOlivier PateyPierre PatozGauthier Pean-De-PonfillyJean Yves PeltierPascale PennAlice PerignonEstelle CateauAlexander PfaffSorya BelazMarc PihetJean-Etienne PiloIsabelle PoilanePhilippe PoirierDidier PoissonDenis PonsLauren PullDorothée QuinioDidier RaffenotMatthieu RevestGladys RobertOlivier RogeauxGabrielle RoosenMilène SassoFrançoise SchmittBoualem SendidYaye SenghorMuriel SilvaJean-Yves SiriezEmilie SitterléFrédéric SorgeMaurellet Evrard SylvieIlhame TantaouiDominique ToubasAli Cherif TouilCéline TournusHélène Yera
Assessment of ex vivo antimalarial drug efficacy in African Plasmodium falciparum parasite isolates, 2016–2023: a genotype–phenotype association study
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Jason RosadoAbebe FolaSandrine CojeanVéronique SarrasinRomain CoppéeJustine BaillyRizwana ZaffaroulahAzza BouzayeneLiliane CicéronLudivine HouzéRebecca CrudaleLise MussetMarc ThellierBruno PradinesJérôme ClainJeffrey BaileySandrine HouzéAhmed AboubacarPatrice AgnameyAbou-Bacar AhmedDaniel AjzenbergAdela AngoulvantFrédéric ArieyBenjamin AubryFirouze BanisadrSorya BelazGhania BelkadiGhania Belkacem BelkadiAnne Pauline BellangerDieudonné BembaFarida BenaoudiaMartine BlochFrancoise BotterelVincent BoudenMarie-Elisabeth BougnouxCaren BrumpSophie BrunJulie BrunetBernadette BuretPauline Caraux-PazNourrisson CelineSylvain ClauserElodie CollinNaima DahaneCéline DamianiEric DannaouiCéline DardMarie-Laure DardeAnne DebourgogneThierry DelacourJean-Marie DelarbreAnne DelavalVeronique DelceyAnne-Sophie DeleplancqueGuillaume DesoubeauxNathalie DesuremainGisele DewulfRémy DurandMarie-Fleur DurieuxEmmanuel DutoitOdile EloyJean-François FaucherLoïc FavennecAlbert FayeOdile FenneteauCécile FickoEmilie FrealleGilles GargalaCéline GarnaudLudovic De GentileNadine GodineauJudith GorlickiYohann Le GovicAlain GravetNadia GuennouniSamia HamaneThomas HanslikAntoine HugueninJean-Pierre HurstFakhri JeddiLeroy JordanLuce LandraudHélène LapillonneSébastien LarréchéRose-Anne LavergneJean Philippe LemoineCécile LeprinceElodie LestevenAngèle LiCaroline LohmannBasmaciyan LouiseMarie-Claire MachouartCéline MalassigneAnthony MarteauDanièle MaubonEdith MazarsBruno MégarbaneAna Mendes-MoreiraSylvain MermondGwénaël Le MoalAlicia MorenoPierre MornandJean-Benjamin MuratRené NabiasJerome NaudinGilles NevezCéline NourrissonMouri OussamaNathalie ParezOlivier PateyPierre PatozGauthier Pean-De-PonfillyJean Yves PeltierPascale PennAlice PerignonEstelle CateauAlexander PfaffSorya BelazMarc PihetJean-Etienne PiloIsabelle PoilanePhilippe PoirierDidier PoissonDenis PonsLauren PullDorothée QuinioDidier RaffenotMatthieu RevestGladys RobertOlivier RogeauxGabrielle RoosenMilène SassoFrançoise SchmittBoualem SendidYaye SenghorMuriel SilvaJean-Yves SiriezEmilie SitterléFrédéric SorgeMaurellet Evrard SylvieIlhame TantaouiDominique ToubasAli Cherif TouilCéline TournusHélène Yera
- Organismes : Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Brown University Biologie moléculaire et immunologie parasitaires et fongiques Université Paris-Saclay Centre National de Référence Paludisme [AP-HP Hôpital Bichat-Claude Bernard] Centre National de Référence Paludisme [AP-HP Hôpital Bichat-Claude Bernard] Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie-Mycologie, CHU d'Angers, Angers, SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest]
- Publié dans EBioMedicine le 28/10/2020
Résumé : Background: Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount. Methods: We measured the susceptibility to six antimalarials using ex vivo growth inhibition assays (IC50) for a total of 805 Plasmodium falciparum isolates obtained from travellers returning to France (2016-2023), mainly from West and Central Africa. Isolates were sequenced using molecular inversion probes (MIPs) targeting forty-three genes across the parasite genome, of which nineteen are drug resistance genes. Findings: Ex vivo susceptibility of all assessed antimalarial compounds was consistent with their potent activity. The median IC50 values for the six drugs were 1.1 nM [IQR: 0.8-1.7] for DHA, 16.7 nM [9.9-27.4] for LMF, 29.5 nM [19.1-45.5] for MFQ, 23.4 nM [17.1-39.0] for MDAQ, 26.7 nM [18.0-41.2] for CQ, and 18.5 nM [15.1-24.3] for PPQ. Only four isolates carried a validated pfkelch13 mutation. Multiple mutations in pfcrt and one in pfmdr1 (Asn86Tyr) were significantly associated with altered susceptibility to multiple drugs, and their frequencies decreased over time. Pfcrt and pfmdr1 mutations altered susceptibility to lumefantrine and mefloquine in an additive manner, with the wild-type haplotype (pfcrt K76-pfmdr1 N86) exhibiting the lowest susceptibility. Interpretation: Our study on P. falciparum isolates from West and Central Africa indicates a low frequency of molecular markers associated with artemisinin resistance and a modest but significant decrease (1.6-2.3X) in the frequency of multidrug resistance markers. These genotypic changes likely mark parasite adaptation to sustained drug pressure and call for intensifying the monitoring of antimalarial drug resistance in Africa.
Fichiers liés : 2025_Rosado_eBioMedicine.pdf
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Yeast fungaemia among injection drug users in France (2012–2022): a cross-sectional observational study
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Olivier LortholaryOlivier LortholarySebastien ImbertValerie Letscher-BruKarine Boukris-SitbonThomas ObadiaFrederic DalleLilia HasseineFlorent MorioAntoine HugueninPhilippe PoirierLoïc FavennecJulie BonhommeAlexandre AlanioFanny LanternierM. Desnos-OllivierTaieb ChouakiMarc PihetAnne-Pauline BellangerMagalie DemarNicole Desbois-NogardMuriel NicolasMarie-Fleur DurieuxMilène SassoEstelle CateauJean-Pierre GangneuxCaroline MahincSophie CassaingAdélaïde ChesnayGuillaume DesoubeauxAndré PaugamElisabeth ChachatyMarie-Elisabteth BougnouxLilia MerabetPatricia MarianiMaité Micaelo
Yeast fungaemia among injection drug users in France (2012–2022): a cross-sectional observational study
- Type de publi. : Article dans une revue
- Date de publi. : 01/08/2025
- Auteurs : Olivier LortholaryOlivier LortholarySebastien ImbertValerie Letscher-BruKarine Boukris-SitbonThomas ObadiaFrederic DalleLilia HasseineFlorent MorioAntoine HugueninPhilippe PoirierLoïc FavennecJulie BonhommeAlexandre AlanioFanny LanternierM. Desnos-OllivierTaieb ChouakiMarc PihetAnne-Pauline BellangerMagalie DemarNicole Desbois-NogardMuriel NicolasMarie-Fleur DurieuxMilène SassoEstelle CateauJean-Pierre GangneuxCaroline MahincSophie CassaingAdélaïde ChesnayGuillaume DesoubeauxAndré PaugamElisabeth ChachatyMarie-Elisabteth BougnouxLilia MerabetPatricia MarianiMaité Micaelo
- Organismes : Hôpital Necker - Enfants Malades [AP-HP] Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology Hôpital Necker - Enfants Malades [AP-HP] Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology CHU de Bordeaux Pellegrin [Bordeaux] Centre Hospitalier Universitaire [Strasbourg] Pathogens Host Arthropod Vectors Interfaces Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB CHU Dijon Hôpital l'Archet Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Hôpital universitaire Robert Debré [Reims] Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Université de Clermont-Ferrand CHU Clermont-Ferrand CHU Rouen Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology Hopital Saint-Louis [AP-HP] Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology Hôpital Necker - Enfants Malades [AP-HP] Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals Mycologie translationnelle - Translational Mycology
- Publié dans The Lancet Regional Health - Europe le 21/04/2021
Résumé : Background Intravenous injection drug use (IVDU) is an established but infrequent risk factor for yeast fungaemia. We aimed to identify features and outcomes of yeast fungaemia associated with IVDU in a nationwide surveillance network in France. Methods We prospectively included episodes of yeast fungaemia in adults between 2012 and 2022. Episodes with any history of IVDU were considered IVDU-associated. We compared clinical characteristics, infecting species, antifungal treatments, and 90-day mortality between groups. We used Fisher's exact test for categorical variables and the Kruskal–Wallis test for continuous variables. Findings We recorded 9549 episodes of yeast fungaemia among 9132 adults. Among these, 183 (1·9%) were IVDU-associated. Compared with non-IVDU, individuals with IVDU-associated fungaemia were younger and less likely to have a history of malignancy (13·8%, 20/145 vs. 49·5%, 4447/8987, p < 0·0001) or recent surgery (24·3%, 34/140 vs. 37·3%, 3261/8,733, p = 0·0014), and more likely to have deep-seated infections (14·5%, 21/145 vs. 3·4%, 307/8987, p < 0·0001). IVDU cases less often involved Candida albicans (30·1%, 55/183 vs. 47·6%, 4458/9366, p < 0·0001) and more often involved mixed-species infections (13·1%, 24/183 vs. 4·3%, 402/9366), p < 0·0001. Meyerozyma guilliermondii and Wickerhamomyces anomalus were overrepresented among IVDU cases (6·0%, 11/183 vs. 0·5%, 48/9366, p < 0·0001 and 5·5%, 10/183 vs. 0·05%, 5/9366, p < 0·0001, respectively). The crude 90-day case-fatality ratio was 20·7% (95% CI: 13·7%–29·2%) in the IVDU group versus 48·4% (95% CI: 47·3–49·5%) for non-IVDU. Interpretation IVDU-associated yeast fungaemia presents distinct clinical and microbiological characteristics, highlighting the need for tailored diagnosis and management.
Fichiers liés : PIIS2666776225001577.pdf
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