Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Mengjia WangPhilippe CiaisFrédéric FrappartShengli TaoLei FanRui SunXiaojun LiXiangzhuo LiuHuan WangWigneron J.-P.
• Organismes : Zhengzhou University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Peking University [Beijing] Southwest University [Chongqing] Beijing Normal University Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Effective monitoring of soil and vegetation properties on a global scale is essential for better understanding climate changes, hydrological dynamics, and ecological processes. Passive microwave remote sensing at C-band radio frequency, with long observation period and relatively high penetration capability, has been widely used to retrieve soil moisture (SM) and vegetation optical depth (C-VOD). The retrieval process is generally achieved by inversion of the ti-w radiative transfer model, which depends on crucial parameters such as effective scattering albedo (w) and soil roughness (HR) R ) for accurate retrievals. Current SM/C-VOD retrieval algorithms, such as the Land Parameter Retrieval Model (LPRM), predominantly rely on globally-constant w and HR R values, ignoring the inherent sensitivity of those parameters to varying soil conditions and vegetation types. To evaluate the impact of w and HR R variables on SM and C-VOD retrievals and to improve their accuracy, this study proposed and evaluated a novel retrieval approach from AMSR2 C-band observations during 2017-2020 using the C-band Microwave Emission of the Biosphere (C-MEB) model. We evaluated two new retrieval algorithms, considering either a globally-constant calibration or a land cover-based calibration of w and HR. R . As a benchmark for the calibration, we optimized the values of w and HR R by evaluating the retrieved SM against in situ measurements from the International Soil Moisture Network (ISMN) and OzNet hydrological monitoring networks. The main originality compared to previous algorithms is that i) it includes a comprehensive calibration exploring the optimal values of w and HR, R , applicable globally or tailored to specific land cover; ii) field SM measurements were leveraged to constrain the calibrated value of w and HR. R . For the globally-constant calibration, the optimal values of w = 0.05 and HR R = 0.1 were found to yield the best results. For the land cover-based calibration, an inverse relationship between w/HR R and canopy height was observed, with w ranging from 0.04 to 0.06 and HR R ranging from 0.1 to 0.7 for heights between 0 and 30 m. The algorithm employing a land cover-based calibration (INRAE Bordeaux 2, IB2) exhibited better performance than the one utilizing a globally-constant calibration (INRAE Bordeaux 1, IB1) in evaluating retrieved SM against in situ measurements, as well as in evaluating C-VOD vs various vegetation variables including aboveground biomass (AGB), tree cover, canopy height and several optical vegetation indices. Comparison with LPRM suggested that our IB2 C-VOD retrievals present improved performances in terms of both spatial and temporal results with all considered vegetation variables (spatial correlation (R) between various vegetation variables and C-VOD of 0.76-0.83 for IB2 vs 0.69-0.79 for LPRM), and exhibited lower saturation effects when compared with AGB. In addition, the IB2 SM produced lower root mean squared error (RMSE) (0.147 vs 0.217 m3/m3), 3 /m 3 ), bias (-0.03 vs 0.09 m3/m3), 3 /m 3 ), and ubRMSE (0.066 vs 0.067 m3/m3) 3 /m 3 ) when compared with in situ measurements, although it showed a lower R compared to LPRM SM.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Vilma DembitzHannah LawsonRichard BurtSirisha NataniCéline PhilippeSophie C JamesSamantha AtkinsonJozef DurkoLydia M WangJoana CamposAoife M S MageeKeith WoodleyMichael J AustinAna Rio-MachinPedro CasadoFindlay Bewicke-CopleyGiovanny Rodriguez BlancoDiego Pereira-MartinsLieve OudejansEmeline BoetAlex Von KriegsheimJuerg SchwallerAndrew FinchBela PatelJean-Emmanuel SarryJérôme TamburiniJan Jacob SchuringaLori HazlehurstJohn A Copland IiiMariia YunevaBarrie PeckPedro R CutillasJude FitzgibbonKevin Rouault-PierreKamil KrancPaolo Gallipoli
• Organismes : Barts Cancer Institute Queen Mary University of London University of Zagreb Queen Mary University of London The Institute of Cancer Research The Francis Crick Institute [London] Imperial College London Queen Mary University of London Barts Cancer Institute Queen Mary University of London Oncogenesis, Stress, Signaling Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Imperial College London The Francis Crick Institute [London] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The Institute of Cancer Research Queen Mary University of London Barts Cancer Institute The Institute of Cancer Research Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Universidad Autónoma de Madrid Queen Mary University of London Barts Cancer Institute Instituto de Investigación Sanitaria Fundación Jiménez Diaz [Madrid] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The University of Edinburgh University Medical Center Groningen [Groningen] University of Groningen [Groningen] University Medical Center Groningen [Groningen] University of Groningen [Groningen] Centre de Recherches en Cancérologie de Toulouse The University of Edinburgh Université de Bâle = University of Basel = Basel Universität Queen Mary University of London Barts Cancer Institute Queen Mary University of London Centre de Recherches en Cancérologie de Toulouse Communauté d'universités et établissements de Toulouse Université de Genève = University of Geneva Swiss Institute for Experimental Cancer Research - Lausanne University Medical Center Groningen [Groningen] University of Groningen [Groningen] Mayo Clinic [Jacksonville] The Francis Crick Institute [London] Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute Queen Mary University of London Barts Cancer Institute The Institute of Cancer Research Queen Mary University of London Barts Cancer Institute
• Publié dans Leukemia le 25/10/2020

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Résumé : Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) patients’ outcomes. We identify stearoyl-CoA desaturase (SCD), the key enzyme in fatty acid (FA) desaturation, as prognostic of patients’ outcomes and, using the clinical-grade inhibitor SSI-4, show that SCD inhibition (SCDi) is a therapeutic vulnerability across multiple AML models in vitro and in vivo. Multiomic analysis demonstrates that SCDi causes lipotoxicity, which induces AML cell death via pleiotropic effects. Sensitivity to SCDi correlates with AML dependency on FA desaturation regardless of mutational profile and is modulated by FA biosynthesis activity. Finally, we show that lipotoxicity increases chemotherapy-induced DNA damage and standard chemotherapy further sensitizes AML cells to SCDi. Our work supports developing FA desaturase inhibitors in AML while stressing the importance of identifying predictive biomarkers of response and biologically validated combination therapies to realize their full therapeutic potential.

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Fichiers liés : s41375-024-02390-9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Kassandra ZachosOphélia GodinJaehyoung ChoiJae JungBruno AouizerateValérie AubinFrank BellivierR. Raoul BelzeauxPhilippe CourtetCaroline DubertretBruno EtainEmmanuel HaffenA. Antoine LefrerePierre-Michel LlorcaEmilie OliéMircea PolosanLudovic SamalinRaymund SchwanPaul RouxCaroline BarauJean Romain RichardRyad TamouzaMarion LeboyerAna AndreazzaB. EtainE. OliéMarion LeboyerE. HaffenPierre-Michel LlorcaV. BarteauS. BensalemO. GodinH. LaouamriK. SouryisS. HotierAmandine PelletierF. HergetaJ. PetrucciL. WillaumeF. BellivierV. HennionE. MarlingeJ. MeheustA. RichardM. CarminatiH. FrancisqueC. DubertretN. MazerC. PortalierC. ScognamiglioA. BingP. LaurentS. GardKatia M'BailaraC. ElkaelF. HoorelbekeI. MinoisJ. SportichN. da RosL. BoukhobzaPhilippe CourtetS. DenatB. DeffinisD. DucasseM. GachetA. LengvenytéF. MolièreL. NassG. TarquiniA. LefrereE. MoreauJ. PastolF. GroppiH. PolomeniJ. BaubergL. LescalierI. MuraccioliA. SurayR. CohenJ.P. KahnM. MilazzoO. Wajsbrot-ElgrabliThierry BougerolA. PouchonA. BertrandB. FredembachA. SuisseQ. DenoualM. PolosanA.M. GalliotL. BrehonG. BonnyL. DurandV. FeugaN. KayserP. RouxV. AubinI. CussacM.A. DupontJ. LoftusI. MedecinL. SamalinP.M. LlorcaM. MennetrierT. BonnetD. LacelleM. VayssiéC. BealO. Blanc
• Organismes : University of Toronto IMRB - "Biologie du système neuromusculaire" [Créteil] Fondation FondaMental [Créteil] University of Toronto University of Toronto Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Groupe hospitalier universitaire Paris psychiatrie & neurosciences [Paris] Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Université Sorbonne Paris Cité Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Fondation FondaMental [Créteil] Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] CHU Clermont-Ferrand Université Clermont Auvergne Institut Pascal Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Université Clermont Auvergne Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Plateforme de Ressources Biologiques [Henri Mondor AP-HP, Créteil] Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Hôpital Henri Mondor Fondation FondaMental [Créteil] University of Toronto Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou] Centre Psychothérapique de Nancy [Laxou]
• Publié dans Journal of Affective Disorders le 31/10/2020

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Résumé : Background: Nutrition is largely affected in bipolar disorder (BD), however, there is a lack of understanding on the relationship between dietary categories, BD, and the prevalence of metabolic syndrome. The objective of this study is to examine dietary trends in BD and it is hypothesized that diets with increased consumption of seafood and high-fiber carbohydrates will be correlated to improved patient outcomes, and a lower frequency of metabolic syndrome. Methods: This retrospective cohort study includes two French cohorts. The primary cohort, FACE-BD, includes 268 stable BD patients. The second cohort, I-GIVE, includes healthy controls, both stable and acute BD and schizophrenia patients. Four dietary categories were assessed: meat, seafood, low-fiber and high-fiber carbohydrates. Dietary data from two food frequency questionnaires were normalized using min-max scaling and assessed using various statistical analyses. Results: In our primary cohort, the increased high-fiber carbohydrate consumption was correlated to lower prevalence of metabolic syndrome and improved mood. Low-fiber carbohydrate consumption is associated with higher BMI, while higher seafood consumption was correlated to improved mood and delayed age of onset. Results were not replicated in our secondary cohort. Limitations: Our populations were small and two different dietary questionnaires were used; thus, results were used to examine similarities in trends. Conclusions: Overall, various dietary trends were associated with metabolic syndrome, BMI, lactate, mood and age of onset. Improving our understanding of nutrition in BD can provide mechanistic insight, clinically relevant nutritional guidelines for precision medicine and ultimately improve the quality of lives for those with BD.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Marie ArnaudMelissa BakhosCornelia RumpelMarie-France DignacNicolas BottinelliRichard J. NorbyPhilippe GeaironJonathan DebordePierre KostyrkaJulien GernigonJean-Christophe LemeslePierre Polsenaere
• Organismes : Laboratoire Environnement Ressources des Pertuis Charentais Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Institut d'écologie et des sciences de l'environnement de Paris Laboratoire Environnement Ressources des Pertuis Charentais Laboratoire Environnement Ressources des Pertuis Charentais Laboratoire Environnement Ressources des Pertuis Charentais Réserve Naturelle Nationale Lilleau des Niges Ligue pour la Protection des Oiseaux Réserve Naturelle Nationale Lilleau des Niges Ligue pour la Protection des Oiseaux Laboratoire Environnement Ressources des Pertuis Charentais
• Publié dans Communications Earth & Environment le 27/10/2020

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Résumé : Salt marshes are among the most efficient blue carbon sinks worldwide. The fate of this carbon is uncertain due to limited knowledge about organic matter (OM) decomposition processes under sea-level rise. In an in-situ manipulative experiment, we compared salt marsh OM decomposition and quality across simulated sea-level scenarios (by modifying the inundation) and litter types (absorptive root, fine transportive root, leaves, and rhizomes of Halimione portulacoide) for 170 days. The litter decomposition varied only between the inundation treatments with the longest and shortest durations, while the decomposition differed significantly across litter types, with absorptive roots releasing up to 40% less carbon than other litters. Changes in lignin composition were minimal for absorptive roots and were unaffected by sea-level rise scenarios. Our study suggests that (i) current projections of sea-level rise are unlikely to decrease litter decomposition; (ii) separating litter types might lead to better assessments of salt marshes’ OM dynamics.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Mathieu EchivardJean-Marc SellalChloé ZilioxEloi MarijonPierre BordacharSylvain PlouxKarim BenaliChristelle MarquiéClémence DocqDidier KlugRomain EschalierBaptiste MailleJean-Claude DeharoDominique BabutyThibaud GenetEstelle GandjbakhchAntoine da CostaOlivier PiotDamien MinoisJean-Baptiste GourraudPierre MondolyPhilippe MaurySerge BovedaJean-Luc PasquiéRaphaël P MartinsChristophe LeclercqCharles GuenanciaGabriel LaurentMathieu BeckerJulien BertrandPhilippe ChevalierVladimir ManentiMaciej KubalaPascal DefayePeggy JaconAntoine DesbiollesMarc BadozLaurence Jesel-MorelNicolas LellouchePaul-Ursmar MilliezPaul OllitraultSamir FarehMatthieu BerckerJacques MansouratiBenoît Guy-MoyatJean-Pierre ChabertNicolas LuconiPierre-François WinumFrédéric AnselmeFabrice ExtramianaCamille DelahayeFrançois JourdaOlivier BizeauMathieu NasarreArnaud OlivierStéphane FromentinThibault VilleminOlivier LevavasseurNéfissa HammacheIsabelle Magnin-PoullHugues BlangyNicolas SadoulKévin DuarteNicolas GirerdChristian de Chillou
• Organismes : Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle Service de Cardiologie [CHRU Nancy] Université de Lorraine Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire Hôpital Haut-Lévêque [CHU Bordeaux] IHU-LIRYC Université de Bordeaux Hôpital Haut-Lévêque [CHU Bordeaux] IHU-LIRYC Université de Bordeaux IHU-LIRYC Hôpital Haut-Lévêque [CHU Bordeaux] Université de Bordeaux Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Université Clermont Auvergne CHU Clermont-Ferrand Hôpital de la Timone [CHU - APHM] Aix Marseille Université Hôpital de la Timone [CHU - APHM] Aix Marseille Université Centre Hospitalier Régional Universitaire de Tours Université de Tours Centre Hospitalier Régional Universitaire de Tours Université de Tours CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Université Jean Monnet - Saint-Étienne Centre cardiologique du Nord Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Service Cardiologie [CHU Toulouse] Service Cardiologie [CHU Toulouse] Communauté d'universités et établissements de Toulouse Institut des Maladies Métaboliques et Cardiovasculaires Clinique Pasteur [Toulouse] Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes Service de Cardiologie [CHU de Dijon] Université de Bourgogne Physiopathologie et épidémiologie cérébro-cardiovasculaires [Dijon] Service de Cardiologie [CHU de Dijon] Université de Bourgogne Centre hospitalier régional de Metz-Thionville Centre hospitalier régional de Metz-Thionville Hôpital Louis Pradel [CHU - HCL] Université Claude Bernard Lyon 1 Hôpital Privé Jacques Cartier [Massy] Centre Hospitalier Privé Claude Galien - Ramsay Santé CHU Amiens-Picardie CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Université Grenoble Alpes CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Université Grenoble Alpes CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Université Grenoble Alpes Centre Hospitalier Régional Universitaire de Besançon Université de Franche-Comté Hôpitaux Universitaires de Strasbourg Médecine Cardiovasculaire Translationnelle CHU Henri Mondor [Créteil] Université Paris-Est Créteil Val-de-Marne - Paris 12 Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Régional Universitaire de Brest Optimisation des régulations physiologiques Université de Limoges CHU Limoges Université de Reims Champagne-Ardenne Hôpital universitaire Robert Debré [Reims] Université de Reims Champagne-Ardenne Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Nîmes Université de Rouen Normandie CHU Rouen CIC Hôpital Bichat Université Paris Cité Centre Hospitalier de Roubaix Centre hospitalier d'Auxerre Centre Hospitalier Regional d'Orléans Centre Hospitalier Regional d'Orléans Clinique Louis-Pasteur Hôpital Nord Franche-Comté [Hôpital de Trévenans] Polyclinique Reims-Bezannes Hôpital Nord-Ouest [Villefranche sur Saône] Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Service de Cardiologie [CHRU Nancy] Université de Lorraine Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Service de Cardiologie [CHRU Nancy] Imagerie Adaptative Diagnostique et Interventionnelle
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Background and Aims Prophylactic implantable cardioverter–defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e. within 3 months of hospital discharge) has not yet been specifically evaluated in post-myocardial infarction patients with impaired LVEF. Such was the aim of this retrospective study. Methods Data analysis was based on a nationwide registry of 1032 consecutive patients with LVEF ≤ 35% after acute myocardial infarction who were implanted with an ICD after being prescribed a wearable cardioverter–defibrillator (WCD) for a period of 3 months upon discharge from hospital after the index infarction. Results ICDs were implanted either because a sustained VA occurred while on WCD (VA+/WCD, n = 72) or because LVEF remained ≤35% at the end of the early post-infarction phase (VA−/WCD, n = 960). The median follow-up was 30.9 months. Sustained VAs occurred within 1 year after ICD implantation in 22.2% and 3.5% of VA+/WCD and VA−/WCD patients, respectively (P < .0001). The adjusted multivariable analysis showed that sustained VAs while on WCD independently predicted recurrence of sustained VAs at 1 year (adjusted hazard ratio [HR] 6.91; 95% confidence interval [CI] 3.73–12.81; P < .0001) and at the end of follow-up (adjusted HR 3.86; 95% CI 2.37–6.30; P < .0001) as well as 1-year mortality (adjusted HR 2.86; 95% CI 1.28–6.39; P = .012). Conclusions In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality.

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Fichiers liés : Manuscript EURHEARTJ-D-23-04158-R3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Ernesto Guerra-FarfanFlavia BorgesMohit BhandariYaiza Garcia-SanchezJorge NuñezJaume Mestre-TorresJordi Tomas-HernandezJordi Teixidor-SerraMariano Balaguer-CastroPablo CastillonAlfred DealbertJulio de Caso RodriguezHector AguadoEnrique GueradoEkaterine PopovaAna Claudia TonelliKumar BalasubramanianJessica VincentValerie HarveyEtri KocaqiGerard SlobogeanP.J. DevereauxLaurent VeevaeteBernard Le Polain De WarouxPatricia Lavand'HommeOlivier CornuKarim TribakJean YombiNassim TouilJigme BhutiaCarol ClinckaertDirk De ClippeleirMaike ReulAmeen PatelVikas TandonLeslie GauthierVictoria R.A. AvramMitchell WinemakerJustin de BeerDiane SimpsonAndrew WorsterKim AlvaradoKrysten GregusKelly LawrenceDarryl LeongPhilip JosephPatrick MagloireBenjamin DeheshiStuart BislandThomas WoodDaniel TushinskiDavid A.J. WilsonShariq HaiderKamal BaliClive KearonYannick Le ManachKamal BaliAnthony AdiliMaria TiboniJohn NearyDavid CowanVickas KhannaAmna ZakiJanet FarrellAnne Marie MacdonaldDavid ConenSteven C.W. WongArsha KarbassiDouglas WrightHarsha ShanthannaRyan CoughlinMoin KhanSpencer WikkerinkFaraaz QuraishiAbdel-Rahman LawendyWaleed KishtaEmil SchemitschTimothy CareyMark MacleodDavid SandersEdward VasarhelyiDebra BartleyGeorge DresserChristina TieszerRichard JenkinsonSteven ShadowitzJacques LeeStephen ChoiHans KrederMarkku NousiainenMonica KunzRavianne TuazonMopina ShrikumarBheeshma RaviDavid WassersteinDavid J.G. StephenDiane NamPatrick D.G. HenryGavin C.A. WoodStephen MannMelanie JaegerMarco L.A. SivilottiChristopher SmithChristopher FrankHeather GrantLeone PloegJeff YachMark HarrisonAaron CampbellRyan BicknellDavide BardanaRobert FeibelKatie McilquhamCatherine GallantSamantha HalmanVenkatesh ThiruganasambandamoorthSara RuggieroWilliam HaddenBrian P.J. ChenStephanie CoupalStephen McmahonLisa McleanHemant ShiraliSyed HaiderCrystal SmithEvan WattsDavid SantoneKevin KooAllan YeeAdemilola OyenubiAaron NauthEmil SchemitschTimothy DanielsSarah WardJeremy HallHenry AhnDaniel WhelanAmit AtreyAmir KhoshbinDavid PuskasKurt DrollClaude CullinanJubin PayendehTina LefrancoisLise MozzonTravis MarionMichael JackaJames GreeneMatthew MenonRobert StiegelmahrDerek DillaneMarleen IrwinLauren BeaupreChad ColesKelly TraskShelley MacdonaldJ.A.I. TrenholmWilliam OxnerC.G. RichardsonNiloofar DehghanMehdi SadoughiAchal SharmaNeil WhiteLoretta OlivieriStephen HuntThomas TurgeonEric BohmSarah TranStephen GiilckTom HupelPierre GuyPeter O'BrienAndrew DuncanGordon CrawfordJunlin HouYanrui ZhaoYang LiuLei ShanAnshi WuJuan MuñozPhilippe ChaudierMarion DouplatMichel Henri FessyVincent PiriouLucie LouboutinJean Stephane DavidArnaud FriggeriSebastien BeroudJean Marie FayetPaul LandaisFrankie Ka Li LeungChristian Xinshuo FangDennis King Hang YeeParag SanchetiChetan PradhanAtul PatilChetan PuramMadhav BorateKiran KudrimotiBharati AdhyeHimanshu DongreBobby JohnValsamma AbrahamRitesh PandeyArti RajkumarPreetha GeorgeAlen SigamaniManesh StephenNitheesh ChandranMohammed AshrafA.M. GeorgekuttyAhamad SulthanS. AdinarayananDeep SharmaSatish BarnawalSrinivasan SwaminathanPrasanna BidkarSandeep MishraJagdish MenonNiranjan MVarghese ZkSantosh HiremathMadhusudhan NcAbhijit JawaliKingsly GnanaduraiCarolin GeorgeAtarao MaddipatiMary KpVijay SharmaKamran FarooqueRajesh MalhotraSamarth MittalChavi SawhneyBabita GuptaPurva MathurShivanand GamangatiVijaylaxmi TripathyPrem MenonMandeep DhillonDevendra ChouhanSharanu PatilRavi NarayanPurushotham LalPrashanth BilchodSurya SinghUttam GattuRavi DashputraPrashant RahateMaurizio TurielGiuseppe De BlasioRiccardo AccettaPaolo PerazzoDaniele StellaMarika BonadiesChiara ColomboStefania FozzatoFabio PinoIlaria MorelliEleonora ColnaghiVincenzo SaliniGiuseppe DenaroLuigi BerettaGiacomo PlacellaGiuseppe GiardinaMirko BindaAnna MarcatoLuca GuzzettiFabio PiccirilloMaurizio CecconiH.M. KhorHou Yee LaiC.S. KumarK.H. CheeP.S. LohKit Mun TanSimmrat SinghLi Lian FooKomella PrakasamSook Hui ChawMeng-Li LeeJoanne H.L. NgimHuck Wee BoonIm Im ChinYdo KleinlugtenbeltEllie B.M. LandmanElvira FlikweertHerbert RoerdinkRoy B.G. BrokelmanHannie Elskamp-MeijermanMaarten HorstJan-Hein M.G. CobbenMasood UmerDilshad BegumAnila AnjumPervaiz HashmiTashfeen AhmedHaroon RashidMujahid KhattakRizwan RashidRiaz LakdawalaShahryar NoordinNaveed JumanRobyna KhanMuhammad RiazSyedah BokhariAyesha AlmasHussain WahabArif AliHammad KhanEraj KhanAamer Nabi NurKholood JanjuaSajjad OrakzaiAbdus KhanKhawaja MustafaMian SohailMuhammad UmarSiddra KhanMuhammad AshrafMuhammad KhanMuhammad ShirazAhmad FurganPaweł ŚlęczkaPiotr DąbekAdam KumońWojciech SatoraWojciech AmbrożyMariusz ŚwięchJacek RycombelAdrian GrzelakIlona Nowak- KózkaJaroslaw GucwaWaldemar MachalaMmampapatla RamokgopaGregory FirthMwalimu KareraMaria FourtounasVirsen SinghAnna BiscardiMuhammad IqbalRyan CampbellMatimba MalulekeCarien MollerLerato NhlapoSithombo MaqungoMargot FlintMarcin NejthardtSean ChettyRubendren NaidooErnesto Guerra-FarfanJordi Tomas-HernandezYaiza Garcia-SanchezMiriam Garrido CluaVicente Molero-GarciaJoan Minguell-MonyartJordi Teixidor-SerraMaria del Mar Villar-CasaresJordi Selga MarsaJuan Porcel-VazquezJose-Vicente Andres-PeiroMarc AguilarJaume Mestre-TorresMaria ColominaPatricia GuilabertM Luisa Paños GozaloLuis AbarcaNuria MartinGemma UsuaPedro Martinez-RipolM.A. Gonzalez PosadaPilar Lalueza-BrotoJudith Sanchez-RayaJorge Nuñez CamarenaAntoni Fraguas-CastanyMariano Balaguer-CastroPere TornerMontsant Jornet-GibertJorge Serrano-SanzJaume Cámara-CabreraMònica Salomó-DomènechChristian Yela-VerdúAnna Peig-FontLaura RicolAnna Carreras-CastañerLuis Martínez-SañudoSusana HerranzCarlos Feijoo-MassóMònica Sianes-GallénPablo CastillόnMartí BernausSaioa QuintasOlga GόmezJordi SalvadorJavier AbarcaCristina EstradaMarga NovellasMercè TorraAlfred DealbertOscar MachoAlexia IvanovEsther ValldoseraMarta ArroyoBorja PeyAntoni YusteLlorenç MateoJulio De CasoRafael AnayaJ.L. Higa-SansoneAngelica MillanVictoria BañosSergio Herrera-MateoJulio De CasoRafael AnayaJ.L. Higa-SansoneAngelica MillanVictoria BañosSergio Herrera-MateoHector AguadoGonzalo Martinez-MunicioRicardo LeónSilvia Santiago-ManiegaAna ZabalzaGregorio LabradorEnrique GueradoAlicia Ramirez-RoldanEncarnacion CruzJuan CanoJose BogalloPaphon SangasoongsongNoratep KulachoteNorachart SirisreetreeruxNachapan PengrungTheerawat ChalacheewaVanlapa ArnuntasupakulTeerapat YingchoncharoenBundit NaratreekoonMiriam KadrySurendini ThayaparanIhab AbdlazizArash AframianArjuna ImbuldeniyaRoya MovahediSherif OmranMarcela VizcaychipiPatricia CorreiaShashank PatilKevin HaireAmy S.E. MayorSally DillinghamLaura NicholsonMohamed ElnaggarJoby JohnShashi NanjayanMartyn ParkerSusan O'SullivanMeir MarmorAmir MatityahuRobert McclellanCurt ComstockAnthony DingPaul ToogoodGerard SlobogeanKatherine JosephRobert O'TooleMarcus SciadiniScott RyanMolly ClarkCharles CassidyKonstantin BalonovSergio BergeseLaura PhiefferAlicia Gonzalez-ZacariasAndrew Marcantonio
• Organismes : Hospices Civils de Lyon Laboratoire de Biomécanique et Mécanique des Chocs
• Publié dans Injury le 27/10/2020

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Résumé : Background Hip fractures carry a substantial risk of complications and death. This study aimed to report the 90-day incidence of mortality, major perioperative complications and in-hospital timelines after a hip fracture in the Spanish HIP ATTACK-1 trial cohort, comparing with the non-Spanish cohort. Methods Prospective cohort study of Spanish patients nested in the HIP ATTACK-1 trial. The HIP ATTACK-1 was an international, randomized, controlled trial (17 countries, 69 hospitals, 7 in Spain, highest recruiting country). Patients were randomized to either accelerated surgery (goal of surgery within 6 h of diagnosis) or standard care. Participants were ≥45 years of age who presented with a low-energy hip fracture requiring surgery. Results Among 534 patients in the Spanish cohort, 69 (12.9 %) patients died at 90 days follow-up, compared to 225 (9.2 %) in the non-Spanish cohort (p = 0.009), mostly due to higher nonvascular related mortality. A composite of major postoperative complication occurred in 126 patients (23.6 %). The most common perioperative complications were myocardial injury (189 patients, 35.4 %), infection with no sepsis (86 patients, 16.1 %) and perioperative delirium (84 patients, 15.7 %); all these complication rates in Spain were significantly higher than the non-Spanish patients (29.2 % p = 0.005; 11.9 % p = 0.008 and 9.2 % p < 0.0001, respectively). Spanish cohort patients were older and had more comorbidities than the non-Spanish cohort, evidencing their greater frailty at baseline. Among Spanish patients, the median time from hip fracture diagnosis to surgery was 30.0 h (IQR 21.1–53.9) in the standard-care group, with 68.8 % of patients receiving surgery within 48 h of diagnosis. This median time was lower in the non-Spanish cohort (22.8 h, IQR 9.5–37.0), where 82.1 % of patients were operated within 48 h. Conclusions In the HIP ATTACK-1 trial, 1 in 8 patients died 90 days after a hip fracture in Spain. The most common complication after a hip fracture was myocardial injury, followed by infection and delirium. Spanish patients had worse outcomes than non-Spanish patients. Research needs to focus on new interventions such as accelerated surgery and perioperative troponin measurement with the appropriate investment of resources, to prevent and identify early these complications with a goal of improving mortality for this high-risk population. Level of evidence II

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Rémy NicolleCindy CanivetLaurent PalazzoBertrand NapoléonMira AyadiCamille PignoletJérôme CrosSophie GourgouJanick SelvesJérôme TorrisaniNelson DusettiPierre CordelierLouis BuscailBarbara BournetBarbara BournetCindy CanivetLouis BuscailNicolas CarrèreFabrice MuscariBertrand SucRosine GuimbaudCorinne CouteauMarion DeslandresPascale RiveraEmily AlouanyNadim FaresKarl BarangeJanick SelvesAnne Gomez-BrouchetAdrian CulettoGuillaume Le CosquerMarion JaffrelotBertrand NapoléonBertrand PujolFabien FumexJérôme DesrameChristine LefortVincent LepilliezRodica GinculPascal ArtruLéa ClavelAnne-Isabelle LemaistreLaurent PalazzoJérôme CrosSarah TubianaNicolas FloriPierre SenessePierre-Emmanuel ColomboEmmanuelle Samalin-ScalziFabienne PortalesSophie GourgouLise RocaClaire Honfo GaCarinne PlassotMarc YchouPierre GuibertChristelle De La FouchardièreMathieu SarabiPatrice PeyratSéverine Tabone-EglingerCaroline RenardGuillaume PiessenStéphanie TruantAlain SaudemontGuillaume MilletFlorence RenaudEmmanuelle LeteurtrePatrick GeléEric AssenatJean-Michel FabreFrançois-Régis SoucheMarie DupuyAnne-Marie Gorce-DupuyJeanne RamosJean-François SeitzJean HardwigsenEmmanuelle Norguet-MonnereauPhilippe GrandvalMuriel DulucDominique Figarella-BrangerVéronique VendrelyClément SubtilEric TerrebonneJean-Frédéric BlancJean-Philippe MerlioDominique Farges-BancelJean-Marc GornetDaniela GerominGeoffroy VanbiervlietAnne-Claire FrinDelphine OuvrierMarie-Christine Saint-PaulPhilippe BerthélémyChelbabi FouadStéphane GarciaNathalie LesavreMohamed GasmiMarc BarthetVanessa CottetCyrille Delpierre
• Organismes : Institut Universitaire du Cancer de Toulouse - Oncopole
• Publié dans EBioMedicine le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Rémy NicolleCindy CanivetLaurent PalazzoBertrand NapoléonMira AyadiCamille PignoletJérôme CrosSophie GourgouJanick SelvesJérôme TorrisaniNelson DusettiPierre CordelierLouis BuscailBarbara BournetBarbara BournetCindy CanivetLouis BuscailNicolas CarrèreFabrice MuscariBertrand SucRosine GuimbaudCorinne CouteauMarion DeslandresPascale RiveraEmily AlouanyNadim FaresKarl BarangeJanick SelvesAnne Gomez-BrouchetAdrian CulettoGuillaume Le CosquerMarion JaffrelotBertrand NapoléonBertrand PujolFabien FumexJérôme DesrameChristine LefortVincent LepilliezRodica GinculPascal ArtruLéa ClavelAnne-Isabelle LemaistreLaurent PalazzoJérôme CrosSarah TubianaNicolas FloriPierre SenessePierre-Emmanuel ColomboEmmanuelle Samalin-ScalziFabienne PortalesSophie GourgouLise RocaClaire Honfo GaCarinne PlassotMarc YchouPierre GuibertChristelle De La FouchardièreMathieu SarabiPatrice PeyratSéverine Tabone-EglingerCaroline RenardGuillaume PiessenStéphanie TruantAlain SaudemontGuillaume MilletFlorence RenaudEmmanuelle LeteurtrePatrick GeléEric AssenatJean-Michel FabreFrançois-Régis SoucheMarie DupuyAnne-Marie Gorce-DupuyJeanne RamosJean-François SeitzJean HardwigsenEmmanuelle Norguet-MonnereauPhilippe GrandvalMuriel DulucDominique Figarella-BrangerVéronique VendrelyClément SubtilEric TerrebonneJean-Frédéric BlancJean-Philippe MerlioDominique Farges-BancelJean-Marc GornetDaniela GerominGeoffroy VanbiervlietAnne-Claire FrinDelphine OuvrierMarie-Christine Saint-PaulPhilippe BerthélémyChelbabi FouadStéphane GarciaNathalie LesavreMohamed GasmiMarc BarthetVanessa CottetCyrille Delpierre
• Organismes : Centre de recherche sur l'Inflammation Centre Hospitalier Universitaire de Toulouse Clinique du Trocadero [Paris] Hôpital privé Jean Mermoz [Lyon] (le programme) Cartes d'identité des tumeurs Centre de recherche sur l'Inflammation Hôpital Beaujon [AP-HP] Université Paris Cité Institut régional de Cancérologie de Montpellier Plateforme nationale qualité de vie et cancer Service d'anatomopathologie Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Centre de Recherche en Cancérologie de Marseille Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Centre de Recherches en Cancérologie de Toulouse Chirurgie Générale et Digestive [Rangueil] Centre de Recherches en Cancérologie de Toulouse Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole
• Publié dans EBioMedicine le 28/10/2020

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Résumé : Background We apply endoscopic ultrasound-guided fine needle aspiration biopsy to cytopathologically diagnose and sample nucleic acids from primary tumours regardless of the disease stage. Methods 397 patients with proven pancreatic adenocarcinoma were included and followed up in a multicentre prospective study. DNA and mRNA were extracted from materials of primary tumours obtained by endoscopic ultrasound-guided fine needle aspiration biopsy and analysed using targeted deep sequencing and RNAseq respectively. Findings The variant allele frequency of the KRAS mutation was used to evaluate the tumour cellularity, ranging from 15 to 20% in all cells, regardless of the tumour stage. The molecular profile of metastatic primary tumours significantly differed from other types of tumours, more frequently having TP53 mutations (p = 0.0002), less frequently having RNF43 mutations, and possessing more basal-like mRNA component (p = 0.001). Molecular markers associated with improved overall survival were: mutations in homologous recombination deficiency genes in patients who received first-line platinum-based chemotherapy (p = 0.025) and wild-type TP53 gene in patients with locally advanced tumours who received radio-chemotherapy (p = 0.01). The GemPred transcriptomic profile was associated with a significantly better overall survival in patients with locally advanced or metastatic pancreatic cancer who received a gemcitabine-based first-line treatment (p = 0.019). Interpretation The combination of genomic and transcriptomic analyses of primary pancreatic tumours enables us to distinguish metastatic tumours from other tumour types. Our molecular strategy may assist in predicting overall survival outcomes for platinum or gemcitabine-based chemotherapies, as well as radio-chemotherapy. Funding Institut National Du Cancer (BCB INCa_7294), CHU of Toulouse, Inserm and Ligue Nationale Contre le Cancer (CIT program).

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Fichiers liés : PIIS2352396424004092.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/11/2024
• Auteurs : Pierre-Éric LauriNathalie ColbachGaëlle DamourJean-Philippe DeguineJoël HuatAmélie LefèvreDelphine MoreauAude Ripoche
• Organismes : Agrosystèmes Biodiversifiés Agroécologie [Dijon] Fonctionnement écologique et gestion durable des agrosystèmes bananiers et ananas Peuplements végétaux et bioagresseurs en milieu tropical Centre de Coopération Internationale en Recherche Agronomique pour le Développement Unité Expérimentale sur les Systèmes Maraîchers Agroécologiques Agroécologie [Dijon] Agroécologie et intensification durables des cultures annuelles

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2024
• Auteurs : Edouard TuaillonMwiya MwyiaKarine BolloreAmandine PisoniPierre-Alain RubboMatthias RichardLaurent KremerMaria M W TongaDuncan ChandaMarianne PeriesRoselyne ValloSabrina Eymard-DuvernayMorgana d'OttaviChipepo KankasaPhilippe Van De PerreJean-Pierre MolesNicolas Nagot
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections University Teaching Hospital [Lusaka] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Institut de Recherche en Infectiologie de Montpellier Institut de Recherche en Infectiologie de Montpellier University Teaching Hospital [Lusaka] University Teaching Hospital [Lusaka] Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections University Teaching Hospital [Lusaka] Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections CHU Montpellier = Montpellier University Hospital
• Publié dans International Journal of Infectious Diseases le 31/10/2020

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Résumé : Objectives: The diagnostic gaps for childhood tuberculosis (TB) remain considerable in settings with high TB incidence and resource constraints. We established and evaluated the performance of a scoring system based on a combination of serological tests and T-cell cytokine release assays, chosen for their ability to detect immune responses indicative of TB, in a context of high prevalence of pediatric HIV infection. Methods: We enrolled 628 consecutive children aged ≤15 years, admitted for TB suspicion. Multiple cytokine levels in QuantiFERON Gold In-Tube supernatants and antigen 85B (Ag85B) antibodies were assessed in children who tested positive with either Xpert TB or mycobacterial culture. The results were compared with those of control children. Results: Among the biomarkers most strongly associated with TB, random forest classification analysis selected Ag85B antibodies, interleukin-2/interferon-γ ratio, and monokine induced by interferon-γ for the scoring system. The receiver operating characteristic curve derived from our scoring system showed an area under the curve of 0.95 (0.91-0.99), yielding 91% sensitivity and 88% specificity. The internal bootstrap validation gave the following 95% confidence intervals for the score performance: sensitivity 71%-97% and specificity 79%-99%. Conclusions: This study suggests that supplementing the QuantiFERON assay with a combination of serological and T-cell markers could enhance childhood TB screening regardless of HIV status and age. Further validation among the target population is necessary to confirm the performance of this scoring system.

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Fichiers liés : PIIS1201971224003199.pdf

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