Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 31/10/2024
• Auteurs : Antoine JouvenelAdrien TassouMaxime ThouayeJérôme RuelMyriam AntriJean-Philippe LeyrisAurore PaquetSylvie MalliéChamroeum SarLucie DiouloufetCorinne SonrierFrançois DaubeufJuliette BertinStacy AlvesStéphanie VentéoNelly FrossardPatrick CarrollIlana MechalyDidier RognanPierre SokoloffRadhouane DallelPatrick DelmasJean ValmierCyril Rivat
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research

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Résumé : Opioid analgesia is counteracted on chronic use by tolerance and hyperalgesia inducing dose escalation and life-threatening overdoses. Mu opiate receptors (MOR) expressed in primary sensory neurons were recently found to control tolerance and hyperalgesia, but the underlying mechanisms remained elusive. Here we show that genetic inactivation of fms -like tyrosine kinase receptor 3 (FLT3) receptor in sensory neurons abrogates morphine tolerance and hyperalgesia by preventing MOR-induced hyperactivation of the cAMP signaling pathway and subsequent excitatory adaptive processes. Moreover, the specific FLT3 inhibitor BDT001 potentiates morphine analgesia in acute and chronic pain models, without aggravating morphine adverse effects, and reverses tolerance and hyperalgesia once installed. Thus, FLT3 appears as a key regulator of the MOR signaling pathway and its pharmacological blockade shows promise to enhance chronic opioid analgesic efficacy.

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Fichiers liés : FLT32023.03.16.532971v1.full.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 31/10/2024
• Auteurs : Pierre-André LafonMireille Elodie TsitokanaUgo AlendaClémentine Eva PhilibertMathieu OosterlakenMarta CimadevilaJessica MonnicSalomé RouxJulie BessiéSéverine DiemFranck VandermoereLaurent PrézeauPatrick ChamesJulie KniazeffSylvie ClaeysenJean-Philippe PinVéronique PerrierJian-Feng LiuPhilippe Rondard
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut des Neurosciences de Montpellier Huazhong University of Science and Technology [Wuhan] Institut de Génomique Fonctionnelle

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Résumé : Immunotherapy of Alzheimer's disease (AD) is a promising approach to reduce the accumulation of amyloid-beta (Aβ), a critical event in the onset of the disease. Targeting the group II metabotropic glutamate receptors, mGlu2 and mGlu3, could be important in controlling Aβ production, although their respective contribution remains unclear due to the lack of selective tools. Here, we show that enhancing mGlu2 receptor activity increases Aβ1-42 peptide production whereas activation of mGlu3 has no effect. We show that such a difference likely results from the direct interaction of APP with mGlu3, but not with mGlu2 receptors, that prevents APP amyloidogenic cleavage and Aβ1-42 peptides production. We then show that chronic treatments of the AD model 5xFAD mice with a brain-penetrating mGlu2-potentiating nanobody accelerated amyloid aggregation and exacerbated memory deficits, but had no effect in control mice. Our results confirm that a selective mGluR2 activation exacerbates AD disease development, suggesting that therapeutic benefices could be obtained with blockers of this receptor. Our study also provides the proof-of-concept that chronic administration of nanobodies targeting neuroreceptors can be envisioned to treat brain diseases.

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Fichiers liés : Lafon- BioRxiv-2024.01.22.576777v1.full.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/10/2024
• Auteurs : Satish TadiArmelle GesnikPhilippe FritFlorence IehlVirginie RoparsFlorent DingliDamarys LoewPatrick CalsouIsabelle CallebautJean-Baptiste CharbonnierJean-Pierre de Villartay
• Organismes : Imagine - Institut des maladies génétiques (IHU) Institut de Biologie Intégrative de la Cellule Institut de pharmacologie et de biologie structurale Institut de Biologie Intégrative de la Cellule Institut de Biologie Intégrative de la Cellule Institut Curie [Paris] Institut Curie [Paris] Institut de pharmacologie et de biologie structurale Institut de minéralogie, de physique des matériaux et de cosmochimie Institut de Biologie Intégrative de la Cellule Imagine - Institut des maladies génétiques (IHU)

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Résumé : Abstract The interaction of several partners with Ku through Ku-binding motifs (KBMs) in their sequences governs their enrolment in NHEJ repair complexes. Here, we first established more specifically the function of KBMs in V(D)J recombination as the molecular basis of functional redundancy between XLF and the NHEJ proteins MRI and PAXX. Then, given the functional redundancy between RAG2 and XLF, we explored the hypothesis of a KBM-mediated interaction between RAG2 and Ku. Through sequence alignment and biophysical methods, we identified a KBM at the C-terminus of RAG2 (R2CT) that mediates its interaction with Ku both in vitro and in cellulo . Notably, we showed that R2CT/Ku interaction is independent of the RAG nuclease activity. Finally, we demonstrated that the respective KBMs of RAG2 and XLF support their functional redundancy for V(D)J recombination.

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2024
• Auteurs : Xavier DubucsThomas LafonRomain AdamSolene LothFlore TabakaFlorian NegrelloMustapha SebbaneValerie BoucherEric MercierMarcel ÉmondSandrine CharpentierFrederic BalenHugo LengletHugo SchmitPaul ClaveriesXavier PereiraYann-Eric ClaessensJean-Philippe DesclefsDelphine DeltaAline LombartHugo SchmitRudy CohenFrançois-Xavier LaborneAlicia GouettaCharlène MourierJonathan DuchenneAyoub TouiharBertrand BoulangerClaire BrocheTran Duc-MinhMaryam SellamiRym HamedBen Hallouda KassaraEmilie GelinJean FabreJulie RosenblattAude-Marie GangneronChloé ChomaratOmbeline SusongLisa OhayonRachid GaouiaouiAnastasia DessenaBastien MenardAdrien PicaudGustave BangalaJuliane BoscRomain BlondetDidier DarraillansSylvie GrgekDavy MurgueFabien ThomasVioletta JauriacAnne ChareyronAlice BoulangerGwendoline GonfrereSylvain ThiriezAlice HurgonMaud FlambardAnna Senon-LalogeTristan BauduinLaurence BertonClotilde CazenaveErnesto MaielloArnaud BacThomas BizouardYassine HicheriMatthieu DanielCaleb FaivreBénédicte ClementHenri Hani KaramGaëtan GiacominFabien CoisyJérémy GuénézanPauline SugranesMelanie RousselPierrick Le BorgneSaid LaribiMathieu Abou-BadraAymeric BodineauAlexandre CharneyMeryl Nguyen van TinhHadrien LaporteYahia YahouiLaurent JacquinRichard ChocronGaëlle Le BailJean SendeThomas OlivierDelphine LevyCamille GerlierSarah AddouMaxime GautierEric BurggraffMarta Cancella de AbreuPierre Aubertein
• Organismes : Pôle Médecine d'urgences [CHU Toulouse] Université Toulouse III - Paul Sabatier Centre de recherche du CHU de Québec-Université Laval Service des urgences [CHU Limoges] Centre d'Investigation Clinique de Limoges Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier Régional Universitaire de Besançon Centre Hospitalier de Beauvais Université des Antilles (Pôle Martinique) Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] CHU Montpellier = Montpellier University Hospital CHU de Québec–Université Laval CHU de Québec–Université Laval CHU de Québec–Université Laval Pôle Médecine d'urgences [CHU Toulouse] Equipe EQUITY (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Equipe EQUITY (CERPOP) Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Université de Bordeaux Centre Hospitalier Princesse Grace Centre Hospitalier Sud Francilien - Centre Hospitalier d'Evry Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Unité de Recherche Clinique [CHSF] Faculté de Médecine - Clermont-Auvergne Centre Hospitalier Henri Mondor d'Aurillac Centre hospitalier Bretagne Atlantique (Morbihan) Service d'Anesthésie Réanimation Institut de mécanique des fluides de Toulouse
• Publié dans BMC Emergency Medicine le 01/11/2020

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Résumé : Background: Head injuries are the leading cause of trauma in Emergency Departments (EDs). Recent studies have shown epidemiological changes in patients consulting ED for head injuries. The main objective of this study was to describe the profile of head injury patients consulting in the EDs in France and assess head injury severity across age groups; the delay between the occurrence of head injury and ED arrival; factors associated with traumatic intracranial hemorrhage (ICH). Methods: This cross-sectional study collected patient data over a three-day period in March 2023. All adult patients (≥ 18 years old) admitted to the ED with a head injury (defined as a trauma to the head) were included. TBI severity was classified according to patients' initial Glasgow Coma Scale score in the ED: severe (3-8); moderate (9 -12); mild (13-15); and simple head trauma in the absence of transient or persistent neurological symptoms. Results: Among the 71 participating EDs, 26,008 patients visited EDs and a total of 1070 patients (4.1%, IC 95 3.9-4.4) presented a head injury were included in the study, with a median age of 68.5 [37-85] years old. Most of the patients (66.7%) were referred to ED after a call to the Emergency Medical Dispatcher (EMD). The median time from head injury to ED visit was 2 h [1.0 - 5.5]. Ground-level falls were the leading cause of head injury (60.3%). Most of patient presented a simple head trauma (n = 715, 66.8%) followed by mild TBI (n = 337, 31.5%). CT head scans were performed for 636 patients (59.6%), of which 58 were positive. Traumatic ICH prevalence was 5.4% (95% CI: 4.1-6.9) and three patients (0.3%) required an urgent neurosurgical intervention. Neither preinjury anticoagulant (p = 0.97) nor antiplatelet (p = 0.93) use was associated with an increased risk of traumatic ICH. Conclusions: One head injury patient out of two presenting in the ED is aged over 65 years. Patients referred by EMD were more likely to visit ED promptly. The majority of older patients underwent a head CT scan and preinjury anticoagulant use was not associated with increased risk of traumatic ICH.

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Fichiers liés : 12873_2024_Article_1124.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/10/2024
• Auteurs : Habeeb YusuffPierre-Emmanuel ZornFranck BlindauerNaji KharoufDavid SémerilGuillaume BierryStéphane KremerJean-Philippe Dillenseger
• Organismes : Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Biomatériaux et Bioingénierie Faculté de chirurgie dentaire - Robert Frank [Strasbourg] Institut de Chimie de Strasbourg Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Faculté de médecine, maïeutique et sciences de la santé [Strasbourg] Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Faculté de médecine, maïeutique et sciences de la santé [Strasbourg] Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Hôpitaux Universitaires de Strasbourg Faculté de médecine, maïeutique et sciences de la santé [Strasbourg]
• Publié dans Physica Medica European Journal of Medical Physics le 30/10/2020

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Résumé :

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Fichiers liés : 1-s2.0-S1120179724010895-main.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/10/2024
• Auteurs : Shreyasi AcharyaApar AgarwalGianluca Aglieri RinellaLuca AgliettaMichelangelo AgnelloNeelima AgrawalZubayer AhammedShakeel AhmadSang Un AhnIshaan AhujaAlexander AkindinovValentina AkishinaMohammad Al-TuranyDmitry AleksandrovBruno AlessandroHaidar Masud AlfandaJose Ruben Alfaro MolinaBushra AliAndrea AliciNegin AlizadehvandchaliAnton AlkinJohan AlmeGiacomo AloccoTorsten AltAnna Rita AltamuraIgor AltsybeevJesus Ricardo Alvarado GarciaCesar Omar Ramirez AlvarezMustafa AnaamCristian AndreiNicodemos AndreouAnton AndronicEvgeny AndronovVenelin AnguelovFederico AntinoriPietro AntonioliNicole ApadulaL AphecetcheHarald AppelshaeuserCarolina ArataSilvia ArcelliRoberta ArnaldiJhoao Gabriel Martins Campos Almeida ArneiroIonut Cristian ArseneMesut ArslandokAndre AugustinusRalf Peter AverbeckDmitry AveryanovMohd Danish AzmiHitoshi BabaAngela BadalaJoonsuk BaeYongwook BaekXiaozhi BaiRaphaelle Marie BailhacheYoshini BailungRenu BalaAlessandro BalbinoAlberto BaldisseriBartosz BalisZarina BanooVeronika BarbasovaFrancesco BarileLuca BarioglioMaria BarlouBanajit BarmanGergely Gabor BarnafoldiLee Stuart BarnbyEmilie Martine BarreauValerie Ramillien BarretLeonardo Barreto de Oliveira CamposClara BartelsKlaus BarthEsther BartschNicole BastidSumit BasuGuillaume BatigneDaniel BattistiniBoris BatyunyaDibakar BauriJose Luis Bazo AlbaIan Gardner BeardenCaitlin BeattiePascal BechtDebadatta BeheraIouri BelikovAilec Bell HechavarriaFrancesca BelliniRene BellwiedSvetlana BelokurovaLucina Gabriela Espinoza BeltranYael Antonio Vasquez BeltranGyula BencediAdel BensaoulaStefania Maria BeoleYaroslav BerdnikovAnastasia BerdnikovaLuisa BergmannMihaela Gabriela BesoiuLatchezar BetevPartha Pratim BhaduriAnju BhasinBuddhadeb BhattacharjeeLivio BianchiJaroslav BielcikJana BielcikovaAlexandre Patrick BigotAnte BilandzicGabor BiroSaikat BiswasNicolas Luc BizeJustin Thomas BlairDmitry BlauMihail Bogdan BlidaruNora BluhmeChristoph BlumeGianluigi BocaFriederike BockTea BodovaJeongsu BokLaszlo BoldizsarMarek BombaraPeter Matthew BondGermano BonomiHerve BorelAlexander BorissovAndres Gerardo Borquez CarcamoElena BottaYoussef El Mard BouzianiLars BratrudPeter Braun-MunzingerMarco BregantMichal BrozGiuseppe Eugenio BrunoValentin Dimitrov BuchakchievMatthew Daniel BucklandDmitry BudnikovHenner BueschingStefania BufalinoPaul Alois BuhlerNazar BurmasovEdith Zinhle ButheleziAleksandr BylinkinSebastian Adam BysiakJuan Carlos Cabanillas NorisMaria Fernanda Torres CabreraMengke CaiHelen Louise CainesAlberto CalivaErnesto Calvo VillarJuan Manuel Mejia CamachoPaolo CameriniFabio de Moraes CanedoSierra Lisa WeyhmillerMihai CarabasAitor Amatriain CarballoFrancesca CarnesecchiRobin Albert Andre CaronLeopoldo Abranches de CarvalhoJavier Ernesto Castillo CastellanosMatteo CastoldiFabio CatalanoSamuele CattaruzziRebecca CerriIrakli ChakaberiaPritam ChakrabortySinjini ChandraSylvain ChapelandMarielle ChartierSouvik ChattopadhaySubhasis ChattopadhyaySukalyan ChattopadhyayMeiyi ChenTiantian ChengCvetan Valeriev CheshkovVasco Miguel Chibante BarrosoDavid Dobrigkeit ChinellatoEmma Sophia ChizzaliJaeyoon ChoSoyeon ChoPeter ChochulaZuzanna Anna ChochulskaDhrubajyoti ChoudhuryPanagiotis ChristakoglouChristian Holm ChristensenPeter ChristiansenTatsuya ChujoMario CiaccoCorrado CicaloMichael Rudolf CiupekGiulia ClaiFabio Filippo ColamariaJonathan Samuel ColburnDomenico ColellaAngelo ColelliManuel ColocciMatteo ConcasGustavo Conesa BalbastreZaida Conesa del ValleGiacomo ContinJesus Guillermo Contreras NunoMaurice CoquetPietro CorteseMauro Rogerio CosentinoFilippo CostaSusanna CostanzaCorentin CotPhilippe CrochetMaciej Marek CzarnynogaAndrea DaineseGautam DangeMeike Charlotte DanischAndrea DanuProttay DasSupriya DasArchita Rani DashSadhana DashAnnalisa de CaroGiacinto de CataldoJan de CuvelandAlessandro de FalcoDaniele de GruttolaNora de MarcoChiara de MartinSalvatore de PasqualeRohaan DebRaffaele del GrandeLuigi Dello StrittoWenjing DengKyle Christian DevereauxPreeti DhankherDomenico Di BariAntonio Di MauroBenedetto Di RuzzaBatoul DiabRaul Arteche DiazThomas DietelYanchun DingJanik DitzelRoberto DiviaOeystein DjuvslandUliana DmitrievaAlexandru Florin DobrinBenjamin DonigusJan Michal DubinskiAndrea DublaPascal DupieuxNatalia DzalaiovaTabea Maria EderRaymond James EhlersFlorian EisenhutRen EjimaDomenico EliaBarbara Ewa ErazmusFrancesca ErcolessiBruno EspagnonGiulio EulisseDavid EvansSergey EvdokimovLaura FabbiettiMattia FagginJ. FaivreFeng FanWenqing FanAlessandra FantoniMarkus FaselAlessandro FelicielloGrigorii FeofilovArturo Fernandez TellezLucas Ferrandi de OliveiraMarta Bertran FerrerAndrea FerreroChiara FerreroAlessandro FerrettiVictor Jose Gaston FeuillardVendulka FilovaDmitry FinogeevFiorella FiondaErlend FlatlandFernando Antonio FlorAmanda Nicole FloresSiegfried Valentin FoertschIlya FokinSergey FokinUmberto FolloEnrico FragiacomoEszter FrajnaUlrich FuchsNicola FunicelloChristophe FurgetArtur FursTakahiro FusayasuJens Joergen GaardhoejeMartino GagliardiAlberto Martin Gago MedinaTanu GahlautCarlos Duarte GalvanSarjeeta GamiDhevan Raja GangadharanParaskevi GanotiJose Maria Garabatos CuadradoJosue Martinez GarciaTonatiuh Garcia ChavezEdmundo Javier Garcia-SolisCorrado GargiuloPiotr Jan GasikHari Mohan GaurAmrit GautamMaria Beatriz de Leone GayMarie GermainRoman August GernhaeuserChandrasekhar GhoshMarco GiacaloneGiulia GioachinSourav Kanti GiriPaolo GiubellinoPiero GiubilatoAude Marie Camille GlaenzerPeter GlasselEwa GlimosDaniel Jia Qin GohVictor Luis Gonzalez SebastianPavel GordeevMarek Boguslaw GorgonKangkan GoswamiSven GotovacVarlen GrabskiLukasz Kamil GraczykowskiEkaterina GreckaAlessandro GrelliCostin GrigorasVladislav GrigoryevSmbat GrigoryanFabrizio GrosaJan Fiete Grosse-OetringhausRaffaele GrossoDavid GrundNadine Alice GruenwaldGabriel Garcia GuardianoRachid GuernaneMaxime Rene Joseph GuilbaudKristjan Herlache GulbrandsenJesper Jan Walter Karlsson GumprechtTuba GundemTaku GunjiWenda GuoAnik GuptaRamni GuptaRashi GuptaKatarzyna GwizdzielLaszlo GyulaiCynthia Marie HadjidakisFakhar Ul HaiderSara HaidlovaMintu HaldarHideki HamagakiYounghoon HanBrian Gerald HanleyRyan Patrick HanniganJoachim HansenMd Rihan HaqueJohn William HarrisAustin Vincent HartonMichael Volker HartungHadi HassanDespina HatzifotiadouPhilip HauerLaura Brittany HavenerErnst HellbarHaavard HelstrupMarvin HemmerTomas HermanSabrina Gabrielle HernandezGerardo Antonio Herrera CorralSarah Nina Edwige HerrmannKristin Fanebust HetlandBenedict HeybeckHartmut HillemannsBoris HippolyteIsis Pihn Marie HobusFelix Willi HoffmannBas HofmanGeun Hee HongMaximilian HorstAdrian HorzykYongzhen HouPeter Zahariev HristovPatrick HuhnLaura Maria HuhtaThomas HumanicAlek HutsonDirk HutterMinyoung Chris HwangRadiy IlkaevMotoi InabaGian Michele InnocentiMikhail IppolitovArtem IsakovTommaso IsidoriMd Samsul IslamSemen IurchenkoMarian IvanovMarian IvanovVladimir IvanovKaare Endrup IversenMiroslaw JablonskiBarbara JacakNicolo JacazioPeter Martin JacobsSlavka JadlovskaJan JadlovskySyaefudin JaelaniCristiane JahnkeMonika Joanna JakubowskaMalgorzata Anna JanikThomas JansonSu-Jeong JiShihai JiaTao JiangAlom Antonio Paz JimenezFlorian JonasDaniel Matthew JonesJohn JowettJerome JungMichael JungAntoine Jean-Simon JuniqueAnton JuskoJetnipit KaewjaiPeter KalinakAlexander Philipp KalweitAyben Karasu UysalDavid KaratovicNikolaos KaratzenisOleg KaravichevTatiana KaravichevaEvgeny KarpechevMaja Jadwiga KarwowskaUdo Wolfgang KebschullMarkus KeilBernhard Franz KetzerJohannes KeulSwapnesh Santosh KhadeAhsan Mehmood KhanShaista KhanAlexei KhanzadeevYury KharlovAnisa KhatunArvind KhuntiaZhanna KhuranovaBjarte KilengBeomkyu KimChong KimDong Jo KimEun Joo KimJaehyun KimJiyoung KimJunlee KimMinjung KimSe Yong KimTaejun KimKento KimuraAleksandrina KirkovaStefan KirschIvan KiselSergey KiselevAdam Ryszard KisielJacek Pawel KitowskiJennifer Lynn KlayJochen KleinSpencer Robert KleinChristian Klein-BoesingMatthias KleinerThomas KlemenzAlexander KlugeChinorat KobdajRyotaro KoharaThorsten Sven KolleggerAndrey KondratyevNatalia KondratyevaJoshua Leon KonigStephan Alexander KonigstorferPiotr Jan KonopkaGeorgui Kornakov VanMaximilian KorwieserSebastian Dominik KoryciakCornelia KosterArtem KotliarovNino KovacicVladimir KovalenkoMarek KowalskiVenelin Valeriev KozhuharovGrigory KozlovIvan KralikAdela KravcakovaLubos KrcalMarian KrivdaFilip KrizekKatarina Krizkova GajdosovaCristiano KrugMario KrugerDiana Maria KrupovaEvgeny KryshenVit KuceraChristian Claude KuhnPaulus Gerardus KuijerTakuya KumaokaDeekshit KumarLokesh KumarNavneet KumarShyam KumarSourav KunduPodist KurashviliAlexey KurepinAlexey KuryakinSvetlana KushpilVladislav KuskovMonika KutylaAndrey KuznetsovMin Jung KweonYoungil KwonSarah Louise La PointePaola La RoccaAnantachai LakrathokMassimo LamannaAimeric Robin LandouRune LangoyPavel LarionovElisa LaudiLukas LautnerRafael Angel Narcio LaveagaRoman LavickaRamona LeaHyungjun LeeIosif-Charles LegrandGauthier LegrasJohannes LehrbachAlexian Marc LejeuneTomasz Marcin LelekRoy Crawford LemmonIldefonso Leon MonzonMarcel Markus LeschEzra Douglas LesserPeter LevaiMingze LiPeiyu LiXiaomei LiBeatrice Eva Liang-GilmanJorgen Andre LienRoman LietavaIris LikmetaBong-Hwi LimSanghoon LimVolker LindenstruthChristian LippmannDonghai LiuJian LiuGianni Shigeru Setoue LiveraroIngrid Mckibben LofnesConstantinos LoizidesSandor LokosJohanna LomkerXavier Bernard LopezErnesto Lopez TorresClement LotteauPengzhong LuZhiyong LuFabiola Viridiana Lugo PorrasJens Robert LuhderMarcello LunardonGrazia LuparelloYugang MaMagnus MagerAntonin MaireEmilia Maria MajerzMartin Vasilev MakarievMikhail MalaevGiovanni MalfattoreNasir Mehdi MalikSalman Khurshid MalikLiudmila MalininaDukhishyam MallickNeelkamal MallickGiuseppe MandaglioSushobhan Kumar MandalAlexandru ManeaVladislav MankoFranck MansoVito ManzariYaxian MaoRobert Waclaw MarcjanGiacomo Vito MargagliottiAnselmo MargottiAna Maria MarinChristina MarkertCiro Fabian Bermudez MarquezPaolo MartinengoMario Ivan Martinez HernandezGines Martinez-GarciaMaria Paula Martins PalharesSilvia MasciocchiMassimo MaseraAlberto MasoniLaure Marie MassacrierOlaf MassenAnnalisa MastroserioSerena MattiazzoAdam Tomasz MatyjaFrancesco MazzaschiMarianna MazzilliYury MelikyanMaria Monalisa de Melo PaulinoArturo Alejandro Menchaca-RochaJesus Eduardo Munoz MendezElisa MeninnoAnjaly Sasikumar MenonMarius Wilm MenzelMichal MeresYasuo MiakeLuca MichelettiDarius MihaiDimitar Lubomirov MihaylovKonstantin MikhaylovNicola MinafraDariusz Czeslaw MiskowiecAbhi ModakBedangadas MohantyMohammed Mohisin KhanMikael Andreas MolanderShirajum MoniraCindy MordasiniDenise Aparecida Moreira de Godoy WillemsIgor MorozovAndreas MorschTeo MrnjavacValeria MucciforaSanjib MuhuriJames Declan MulliganAlice MulliriMarcelo Gameiro MunhozRobert Helmut MunzerHikari MurakamiSean MurrayLuciano MusaJan MusinskyJulian Wojciech MyrchaBharati NaikAnjali Ila NambrathBasanta Kumar NandiRosario NaniaEugenio NappiAdrian Fereydon NassirpourVlad-Iulius NastaseAbhishek NathSubhadeep NathChristine NattrassMomchil Nikolaev NaydenovAlexandra NeaguAdrian-Eduard NegruEvgeniia NekrasovaLukas NellenRoman NepeivodaSigurd NeseNicola NicassioBorge Svane NielsenEmil Gorm NielsenSergey NikolaevSergey NikulinVladimir NikulinFrancesco NoferiniSeoyoung NohPetr NomokonovJaime NormanNorbert NovitzkyPiotr NowakowskiAlexander NyaninJoakim Ingemar NystrandSaehanseul OhAlice Elisabeth OhlsonVitaly OkorokovJanusz OleniaczAnna OnnerstadChiara OppedisanoAntonio Ortiz VelasquezJacek Tomasz OtwinowskiMotomi OyaKen OyamaYvonne Chiara PachmayerSonali PadhanDavide PaganoGuy PaicSergio Paisano GuzmanAntonio PalascianoIaroslav PanasenkoStefano PanebiancoCaterina PantouvakisHanseo ParkJonghan ParkJasper Elias ParkkilaYash PatleyRajendra Nath PatraBiswarup PaulHua PeiThomas PeitzmannXinye PengMichele PennisiStefania PerciballiDmitry Yurevich PeresunkoGuillermo Mesa PerezYury PestovMikkel Tornhoj PetersenVitalii PetrovMihai PetroviciStefano PianoMiroslav PiknaPhilippe PillotOmbretta PinazzaLawrence PinskyChiara PintoSilvia PisanoMateusz Andrzej PloskonMirko PlaninicFabian PliquettDamian Kacper PlociennikMartin PoghosyanBoris PolishchukStefano PolitanoNikola PoljakAmalia PopSarah Julie PorteboeufValerii PozdniakovIrandheny Yoval PozosKshitish Kumar PradhanSidharth Kumar PrasadSuraj PrasadRoberto PreghenellaFrancesco PrinoClaude Andre PruneauIgor PshenichnovMaximiliano PuccioSara PucilloShi QiuLuca QuagliaAswathy Menon Kavumpadikkal RadhakrishnanSimone RagoniAnanya RaiAndry Malala RakotozafindrabeLuciano RamelloFouad RamiMarika RasaSami Sakari RasanenRutuparna RathMax Philip RauchIvan RavasengaKenneth Francis ReadChristian ReckziegelAndreas Ralph RedelbachKrzysztof RedlichCarolina Anna ReetzHector David Regules MedelAttiq Ur RehmanFelix ReidtHaakon Andre Reme-NessKlaus Johannes ReygersAndrei RiabovViktor RiabovRiccardo RicciMatthias Rudolph RichterAnton Albert RiedelWerner RieglerAndrea Giovanni RifferoMichele RignaneseCristina RipoliCatalin-Lucian RisteaManuel Viqueira RodriguezMario Rodriguez CahuantziSaul Anibal Rodriguez RamirezKetil RoeedRoman RogalevElena RogochayaTim Sebastian RogoschinskiDavid Michael RohrDieter RoehrichSolangel Rojas TorresPrzemyslaw Stefan RokitaGleb RomanenkoFederico RonchettiEdgar Dominguez RosasKrystian RoslonAndrea RossiAnkhi RoySubhadeep RoyNicola RubiniJustus Arne RudolphDaniela RuggianoRinaldo RuiPawel Grzegorz RussekRoberto RussoAnar RustamovEvgeny RyabinkinYury RyabovAndrzej Krzysztof RybickiJaehyeok RyuWioleta RzesaBianca SabiuSergey SadovskiyJon-Are SaetreSwati SahaBhagyarathi SahooRaghunath SahooSarita SahooDushmanta SahuPradip Kumar SahuJogender SainiKlaudia TroppShingo SakaiMalavika Panikkassery SalvanSanjeev Singh SambyalDaniel SamitzIsabella SannaThiago Badaro SaramelaDebojit SarkarPranjal SarmaValerio SarritzuValentina Mantovani SartiMike SasSawan SawanEugenio ScapparoneJohann Joachim SchambachHorst Sebastian ScheidClaudiu Cornel SchiauaRainer Martin SchickerFelix SchlepperAlexander SchmahChristian Joachim SchmidtHans Rudolf SchmidtMarten Ole SchmidtMartin SchmidtNicolas SchmidtAustin Robert SchmierRomain SchotterAlexander WilhelmiJurgen SchukraftKai Oliver SchwedaGilda ScioliEnrico ScomparinJanet Elizabeth SegerYuko SekiguchiDaiki SekihataMariia SelinaIlya SelyuzhenkovSerhiy SenyukovJin Joo SeoDmitry SerebryakovLeonid SerkinLaura SerksnyteAdrian SevcencoTebogo Joyce ShabaAlexandre ShabetaiRuben ShahoyanArtem ShangaraevBinti SharmaDeependra SharmaHimanshu SharmaMeenakshi SharmaSamarth SharmaSheetal SharmaUpasana SharmaAfnan ShatatOveis SheibaniKenta ShigakiMaya Hachiya ShimomuraJaehyuck ShinSergey ShirinkinQiye ShouYury SibiryakSabyasachi SiddhantaTeodor SiemiarczukTiago Fiorini da SilvaDavid Olle Rickard SilvermyrTawanchat SimantathammakulRadoslav SimeonovBalwan SinghBhawani SinghKamaljeet SinghRanbir SinghRandhir SinghRavindra SinghSweta SinghVivek SinghVikas SinghalTinku Sarkar - SinhaBranislav SitarMario SittaBernhard SkaaliGeorgijs SkorodumovsNikolai SmirnovRaimond SnellingsEmilie Haugland SolheimJihye SongChristian SonnabendJorine SonneveldFrancesca SoramelAnalyce Bella Soto-HernandezRik SpijkersIwona Anna SputowskaJoey StaaJohanna StachelIonel StanPatrick John SteffanicTim StellhornStephan Friedrich StiefelmaierDiego StoccoIda StorehaugNicolas Justus StrangmannPeter StratmannSofia StrazziAlessandro SturnioloChristos Pliatskas StylianidisAlexandre Alarcon Do Passo SuaideChristophe Pierre SuireMikhail SukhanovMiljenko SuljicRishat SultanovVikash SumberiaSuharyo SumowidagdoMaciej SzymkowskiLorenzo Hernandez TabaresSeyed Farid TaghaviGuillaume TaillepiedJun TakahashiGanesh Jagannath TambaveSiyu TangZebo TangDaniel Jesus Tapia TakakiNicolae TapusLucia Anna TarasovicovaMadalina-Gabriela TarzilaGiovanni Francesco TassielliArturo TauroAndrea Tavira GarciaGuillermo Tejeda MunozLivia TerlizziCristina TerrevoliSanchari ThakurDeepa ThomasAnatoly TikhonovNicolas TiltmannAnthony Robert TimminsMilan TkacikTomas TkacikAlberica ToiaRyoka TokumotoSofia TomassiniKeisuke TomohiroNataliya TopilskayaMarco ToppiVictor Valencia TorresArianna Grisel Torres RamosAntonio TrifiroTriloki TrilokiAndrea Sofia TrioloSushanta TripathyTulika TripathyStefano TrogoloVictor TrubnikovWladyslaw Henryk TrzaskaTomasz Piotr TrzcinskiChristina TsolantaRan TuAlexandr TumkinRosario TurrisiTrine Spedstad TveterKjetil UllalandBerkin UlukutluSahil UpadhyayaAntonio UrasMarta UrioniGianluca UsaiMartin ValaNicolo ValleLennart van DoremalenMarco van LeeuwenCasper Arie van VeenRoelof Jan Gijs van WeeldenPierre Vande VyvreDezso VargaZoltan VargaPaola Vargas TorresMaria VasileiouAndrey VasilievOton Vazquez DoceOmar Vazquez RuedaVladimir VecherninErmanno VercellinRahul VermaLucas Anne VermuntRobert VertesiMarta VerweijLinda VickovicZabulon VilakaziOrlando Villalobos BaillieAnna VillaniAlexander VinogradovTiziano VirgiliMaxim Mikael Olavi VirtaAlexander VodopyanovBenedikt VoelkelMartin Andreas VolklSergey VoloshinGiacomo VolpeBarthelemy von HallerIvan VorobyevNikita VozniukJanka VrlakovaJie WanChunzheng WangDongfang WangYuanzhe WangYubiao WangZhengqing WangAdam Tadeusz WegrzynekFelix Thomas WeiglhoferSandro Christian WenzelJohannes Peter WesselsJens WiechulaJon WikneGrzegorz Andrzej WilkJeremy John WilkinsonGuido Alexander WillemsBernd Stefan WindelbandMichael Andreas WinnJosephina Rae WrightWenya WuYitao WuZhenjun XiongRan XuAnkur YadavArun Kumar YadavYorito YamaguchiShiming YangSatoshi YanoEmma Rose YeatsZhongbao YinIn Kwon YooJin Hee YoonHyeonjin YuShiming YuanAlperen YuncuValentina ZaccoloChiara ZampolliFederica ZanoneNima ZardoshtiAndrey ZarochentsevPetr ZavadaNikolay ZavyalovMikhail ZhalovBiao ZhangChi ZhangLiuyao ZhangMaolin ZhangMingyu ZhangSong ZhangXiaoming ZhangYifei ZhangZhen ZhangMingrui ZhaoVladimir ZherebchevskiiZhi YuDaicui ZhouYou ZhouJianhui ZhuSenjie ZhuYa ZhuStefan Cristi ZugravelNicola Zurlo
• Organismes : Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Physique des 2 Infinis de Lyon Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Institut de Physique des 2 Infinis de Lyon Institut Pluridisciplinaire Hubert Curien Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Institut Pluridisciplinaire Hubert Curien Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de physique subatomique et des technologies associées Institut de Physique des 2 Infinis de Lyon Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont

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Résumé : In this Letter, the first evidence of the ${}^4_{\bar{\Lambda}}\overline{\mathrm{He}}$ antihypernucleus is presented, along with the first measurement at the LHC of the production of (anti)hypernuclei with mass number $A=4$, specifically (anti)${}^4_{\Lambda}\mathrm{H}$ and (anti)${}^4_{\Lambda}\mathrm{He}$. In addition, the antiparticle-to-particle ratios for both hypernuclei (${}^4_{\bar{\Lambda}}\overline{\mathrm{H}}$ / ${}^4_{\Lambda}\mathrm{H}$~and ${}^4_{\bar{\Lambda}}\overline{\mathrm{He}}$ / ${}^4_{\Lambda}\mathrm{He}$) are shown, which are sensitive to the baryochemical potential of the strongly-interacting matter created in heavy-ion collisions. The results are obtained from a data sample of central Pb--Pb collisions, collected during the 2018 LHC data-taking at a center-of-mass energy per nucleon pair of $\sqrt{s_{\mathrm{NN}}} = $ 5.02 TeV. The yields measured for the average of the charge-conjugated states are found to be $[0.78 \; \pm \; 0.19 \; \mathrm{(stat.)} \; \pm \; 0.17 \; \mathrm{(syst.)}] \times 10^{-6}$ for the (anti)${}^4_{\Lambda}\mathrm{H}$ and $[1.08 \; \pm \; 0.34 \; \mathrm{(stat.)} \; \pm \; 0.20 \; \mathrm{(syst.)}] \times 10^{-6}$ for the (anti)${}^4_{\Lambda}\mathrm{He}$, and the measured antiparticle-to-particle ratios are in agreement with unity. The presence of (anti)${}^4_{\Lambda}\mathrm{H}$ and (anti)${}^4_{\Lambda}\mathrm{He}$ excited states is expected to strongly enhance the production yield of these hypernuclei. The yield values exhibit a combined deviation of 3.3$\sigma$ from the theoretical ground-state-only expectation, while the inclusion of the excited states in the calculations leads to an agreement within 0.6$\sigma$ with the present measurements. Additionally, the measured (anti)${}^4_{\Lambda}\mathrm{H}$ and (anti)${}^4_{\Lambda}\mathrm{He}$ masses are compatible with the world-average values within the uncertainties.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 29/10/2024
• Auteurs : Antoine RimbertDamien DuvalDaniel TrujillanoFlorence KyndtAntoine Jobbé-DuvalPierre LindenbaumNathan TuckerSimon LecointePauline LabbéClaire ToquetMatilde KarakachoffJean-Christian RousselChristophe BaufretonPatrick BrunevalCaroline CueffErwan DonalRichard RedonRobert OlasoAnne BolandJean-François DeleuzeXavier EstivillSusan SlaugenhauptRoger MarkwaldRussel NorrisJean-Philippe VerhoyeVincent ProbstAlbert HagègeRobert LevineXavier JeunemaitreHervé Le MarecRomain CapouladeNabila Bouatia-NajiChristian DinaDavid MilanStephan OssowskiJean-Jacques SchottJean MerotSolena Le ScouarnecThierry Le Tourneau
• Organismes : ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire d'Angers ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre for Genomic Regulation - Centre de Regulació Genòmica [Barcelona] Universitat Pompeu Fabra [Barcelona] Hospital del Mar Medical Research Institute Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Hôpital Européen Georges Pompidou [APHP] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image CIC-IT Rennes Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre for Genomic Regulation - Centre de Regulació Genòmica [Barcelona] Universitat Pompeu Fabra [Barcelona] Hospital del Mar Medical Research Institute Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health Medical University of South Carolina [Charleston] Medical University of South Carolina [Charleston] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Massachusetts General Hospital [Boston] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Paris-Centre de Recherche Cardiovasculaire ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Eberhard Karls Universität Tübingen = University of Tübingen ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Universitaire de Nantes = Nantes University Hospital

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Résumé : BACKGROUND: Isolated posterior leaflet mitral valve prolapse (PostMVP), a common form of MVP, often referred as fibroelastic deficiency, is considered a degenerative disease. PostMVP patients are usually asymptomatic and often undiagnosed until chordal rupture. The present study aims to characterize familial PostMVP phenotype and familial recurrence, its genetic background, and the pathophysiological processes involved.METHODS: We prospectively enrolled 284 unrelated MVP probands, of whom 178 (63%) had bi-leaflet MVP and 106 had PostMVP (37%). Familial screening within PostMVP patients allowed the identification of 20 families with inherited forms of PostMVP for whom whole genome sequencing was carried out in probands. Functional in vivo and in vitro investigations were performed in zebrafishand in Hek293T cells.RESULTS: In the 20 families with inherited form of PostMVP, 38.8% of relatives had a MVP/prodromal form, mainly of the posterior leaflet, with transmission consistent with an autosomal dominant mode of inheritance. Compared with control relatives, PostMVP family patients have clear posterior leaflet dystrophy on echocardiography. Patients with PostMVP present a burden of rare genetic variants in ARHGAP24. ARHGAP24 encodes the filamin A binding RhoGTPase-activating protein FilGAP and its silencing in zebrafish leads to atrioventricular regurgitation. In vitro functional studies showed that variants of FilGAP, found in PostMVP families, are loss-of-function variants impairing cellular adhesion and mechano-transduction capacities. CONCLUSIONS PostMVP should not only be considered an isolated degenerative pathology but as a specific heritable phenotypic trait with genetic and functional pathophysiological origins. The identification of loss-of-function variants in ARHGAP24 further reinforces the pivotal role of mechano-transduction pathways in the pathogenesis of MVP.CLINICAL PERSPECTIVE Isolated posterior mitral valve prolapse (PostMVP), often called fibro-elastic deficiency MVP, is at least in some patients, a specific inherited phenotypic trait PostMVP has both genetic and functional pathophysiological origins Genetic variants in the ARHGAP24 gene, which encodes for the FilGAP protein, cause progressive Post MVP in familial cases, and impair cell adhesion and mechano-transduction capacities

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Fichiers liés : 2024.10.16.24315096v1.full.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/10/2024
• Auteurs : Nicolas ChaizeXavier BaudryJean-Luc RouviereEric GautierPierre-Henri JouneauYves DeblockB. GrandidierHermann SellierL. DesplanquePhilippe Ballet
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Laboratoire d'Etude des Matériaux par Microscopie Avancée Modélisation et Exploration des Matériaux Modélisation et Exploration des Matériaux Laboratoire d'économie mathématique et de microéconomie appliquée Modélisation et Exploration des Matériaux Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Centrale de Micro Nano Fabrication - IEMN Physique - IEMN Nano-Electronique Quantique et Spectroscopie EPItaxie et PHYsique des hétérostructures - IEMN Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

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• Type de publi. : Article dans une revue
• Date de publi. : 25/10/2024
• Auteurs : Anna GueiderikhJérémy BaudeDavid BaronRenaud SchiappaSandrine KatsahianDamien MoreauMarc LauransJean-Emmanuel BibaultSarah KrepsPierre-Yves BondiauMagali QuivrinAlexis LépinoyDavid PasquierJean-Michel Hannoun-LeviPhilippe Giraud
• Organismes : Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Université Sorbonne Paris Cité Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Université Côte d'Azur Health data- and model- driven Knowledge Acquisition CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Institut de Cancérologie de Bourgogne Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Université de Lille Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Hôpital Européen Georges Pompidou [APHP] Université Paris Descartes - Paris 5 Université Sorbonne Paris Cité
• Publié dans Frontiers in Oncology le 26/10/2020

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Résumé : Background Nodes are the second site for prostate cancer recurrence. Whole-pelvic radiotherapy (WPRT) has shown superiority over nodal stereotactic body radiotherapy (SBRT) in two retrospective cohorts. We aimed to compare both modalities and assess factors associated with treatment outcomes. Materials and methods This retrospective multicentric cohort study included patients from five institutions spanning from 2010 to 2022. Patients had a history of prostatic adenocarcinoma classified as N0 M0 at diagnosis with a first nodal-only pelvic castration-sensitive recurrence. Failure-free survival (FFS) was defined as the time from the end of RT to the first failure event–biochemical or imaging recurrence, or death. Results A total of 147 patients (pts) were analyzed, mainly treated for a recurrence after initial prostatectomy (87%), with 64 (43.5%) undergoing SBRT and 83 (56.5%) undergoing WPRT. SBRT was chosen mainly for dosimetric constraints (67%) and was associated with a lower rate of concomitant androgen deprivation therapy (ADT) prescription. With a median follow-up of 68 months [inter-quartile range (IQR) = 51], FFS was significantly lower in the SBRT group (p < 0.0001). In multivariable analysis, WPRT and ADT were associated with a longer FFS. Factors associated with a longer FFS after SBRT included associated ADT, lower prostate-specific antigen (PSA) levels, a PSA doubling time >6 months, and a Gleason score <8. SBRT was associated with a lower rate of genitourinary and gastrointestinal grade ≥2 complications. Discussion For an isolated pelvic nodal prostate cancer recurrence, SBRT is associated with a shorter FFS compared to WPRT. SBRT is often more convenient for patients and leaves further pelvic salvage options available, so it can be explored as an option for well-informed patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/10/2024
• Auteurs : Leticia SarloCoraline DurouxYohann ClémentPierre LanteriFabien RossettiOlivier DavidAugustin TillementPhilippe GilletAgnès HagègeL. DavidMichel DumoulinRichard MarchalThéodore TillementFrançois LuxOlivier Tillement
• Organismes : iLM - Formation, élaboration de nanomatériaux et cristaux M&Wine Institut des Sciences Analytiques ISA-CheMod Institut des Sciences Analytiques Université Claude Bernard Lyon 1 iLM - Formation, élaboration de nanomatériaux et cristaux [GIN] Grenoble Institut des Neurosciences Institut de Neurosciences des Systèmes iLM - Formation, élaboration de nanomatériaux et cristaux Nano-H Université Paris-Saclay ISA-Separative Methods - Techniques séparatives Ingénierie des Matériaux Polymères Laboratoire d'Oenologie et de Chimie Appliquée M&Wine iLM - Formation, élaboration de nanomatériaux et cristaux iLM - Formation, élaboration de nanomatériaux et cristaux
• Publié dans OENO One le 28/10/2020

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Résumé : For the wine industry, ensuring quality and authenticity hinges on the precise determination of wine origin. In our study, we developed a fast semi-quantitative method to analyse 41 chemical elements in wine, employing inductively coupled plasma mass spectrometry (ICP-MS). This methodology characterises what we term the mineral wine profile (MWP). In contrast to an organic molecular profile, the mineral composition of a wine remains constant from the moment it is bottled. Mineral elements play a crucial role in the terroir of wine: they pass primarily from soil to grape and are then influenced by various vinification techniques. Indeed, it is widely recognised that the original soil characteristics are altered by a multitude of winemaking procedures, presenting a considerable challenge when endeavouring to extract origin-related information in a typical scenario. Our study demonstrates that statistical analyses and artificial intelligence (AI) could be a tool for accurately deciphering origin information within the MWP, provided sufficient mineral elements are measured and a comprehensive database of wine samples is employed to establish effective learning. In this study, a dataset comprising 12,966 MWPs was created in just over a year. The first analysis revealed correlations between the elements in wine, especially between rare earth elements, between macronutrients and between micronutrients. A machine learning method was then developed to assess wine origin and principal grape variety. Six models were tested by comparing the area under the receiver operating characteristic curve (AUC), with eXtreme Gradient Boosting as the chosen model. Mean accuracies of 92 % for country classification, 91 % for the French wine region, and 85 % for the main grape variety were obtained, and mean AUC scores of 0.964 for country classification, 0.961 for the French wine region and 0.914 for the main grape variety. This study represents the first comprehensive investigation at this scale on wine samples, and underscores the importance of using a comprehensive MWP dataset for AI applications when verifying wine origin. The authentication of a wine with over 99 % specificity could be routinely achievable through this approach.

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Fichiers liés : 2024_OenoOne_Sarlo.pdf

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