Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2011
• Auteurs : Michel AntonakiosGuillaume Jean-Paul Claude BecqStéphane BonnetRégis GuillemaudPhilippe KahaneYannis CarituAlain BourgerettePierre JallonBernard Thomas-VialettesFrançoise Thomas-VialettesDominique GerbiDaniel EjnesPierre Chapat
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information GIPSA-Services GIPSA - Communication Information and Complex Systems Heuristique et Diagnostic des Systèmes Complexes [Compiègne] Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques MOVEA SA Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Association EPI [épilepsie progression intégration] Association EPI [épilepsie progression intégration] FCEs FCEs CTR Medical
• Publié dans Innovation and Research in BioMedical engineering le 30/10/2020

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Résumé : The EPIMOUV project aims at providing a place to live and autonomy for drug-resistant epileptic young adults while attempting to provide them a high level of security. In this framework, subjects will be monitored during night using body-worn motion sensors and an alarm will be triggered if an on-going seizure is detected by processing the accelerometer readings. In this paper, we describe an innovative architecture for such alarm system: the wireless inertial sensors are positioned on the subject's body; the RF transceiver is located in the subject's room and linked to an Ethernet gateway, and the remote motion capture acquisition system is interfaced with a medicalized alarm system. The EPIMOUV system will be evaluated in a specialized institution from December 2010.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/03/2011
• Auteurs : Anders MårellPhilippe BallonChristophe BaltzingerV. BoulangerJean-Pierre Hamard
• Organismes : Écosystèmes forestiers Écosystèmes forestiers Écosystèmes forestiers Office National des Forêts Écosystèmes forestiers

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Résumé : Des fortes densités de cervidés en Amérique du Nord et en Europe ont modifié, ces dernières décennies, la structure et la composition des communautés végétales des forêts tempérées et boréales. De fait, ces communautés ont basculé vers des états de substitution, couplés à la disparition locale d'espèces indigènes et à la réduction de la diversité spécifique. Dans ce contexte d'abondance non maîtrisée, gestionnaires et scientifiques considèrent les cervidés comme une menace pour la végétation du sous bois et les organismes qui en dépendent. Dans nos travaux, en France et en Amérique du Nord, nous avons pu montrer qu'effectivement l'abondance des cervidés peut perturber, voire interdire, le renouvellement de certains peuplements. Nous avons également constaté, de manière plus générale, que les abroutissements induisent une influence néfaste sur certaines espèces semi-ligneuses et ligneuses de la strate arbustive. A contrario, nous avons observé, plus récemment, des effets positifs sur la richesse et la diversité de la strate herbacée. Nous avons aussi montré que les cervidés peuvent participer à la dissémination des plantes et, dans le massif d'Arc-en-Barrois (Haute-Marne, France), à la propagation d'une espèce rare. En considérant que les ongulés sauvages occasionnent à la fois des effets positifs et négatifs, nous suggérons d'évaluer leur potentiel comme acteurs pour la gestion de la diversité de la flore forestière.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/03/2011
• Auteurs : Solveig BadilloThomas VincentPhilippe Ciuciu
• Organismes : Modelling brain structure, function and variability based on high-field MRI data IFR49 - Neurospin - CEA IFR49 - Neurospin - CEA Modelling and Inference of Complex and Structured Stochastic Systems Modelling brain structure, function and variability based on high-field MRI data IFR49 - Neurospin - CEA

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Résumé : Inter-subject analysis of functional Magnetic Resonance Imaging (fMRI) data relies on single intra-subject studies, which are usually conducted using a massively univariate approach. In this paper, we investigate the impact of an improved intra-subject analysis on group studies. basically the joint detection-estimation (JDE) framework where an explicit characterization of the Hemodynamic Response Function (HRF) is performed at a regional scale and a stimulus-specific adaptive spatial correlation model enables the detection of activation clusters at voxel level. For the group statistics, we conducted several Random effect analyses (RFX) which relied either on the General Linear Model (GLM), or on the JDE analyses, or even on an intermediate approach named Spatially Adaptive GLM (SAGLM). Our comparative study perfomed during a fast-event related paradigm involves 18 subjects and illustrates the regionspecific differences between the GLM, SAGLM and JDE analyses in terms of statistical sensitivity. On different contrasts of interest, spatial regularization is shown to have a beneficial impact on the statistical sensitivity. Also, by studying the spatial variability of the HRF, we demonstrate that the JDE framework provides more robust detection performance in cognitive regions due to the higher hemodynamic variability in these areas.

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Fichiers liés : isbi.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/03/2011
• Auteurs : Anne PuissantChristiane WeberAziz SerradjGrzegorz SkupinskiJean-Philippe MaletJulien TravellettiPierre GançarskiNicolas Passat
• Organismes : Laboratoire Image, Ville, Environnement Laboratoire Image, Ville, Environnement Laboratoire Image, Ville, Environnement Laboratoire Image, Ville, Environnement Institut de physique du globe de Strasbourg Ecole et Observatoire des Sciences de la Terre Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection Laboratoire des Sciences de l'Image, de l'Informatique et de la Télédétection

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• Type de publi. : Article dans une revue
• Date de publi. : 29/03/2011
• Auteurs : Yacine BoulaftaliBenoit Ho-Tin-NoéAna PenaStéphane LoyauLaurence VenisseDéborah FrançoisBenjamin RichardVéronique ArocasJean-Philippe ColletMartine Jandrot-PerrusMarie-Christine Bouton
• Organismes : Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Génétique épidémiologique et moléculaire des pathologies cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Génétique épidémiologique et moléculaire des pathologies cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires Hémostase, bio-ingénierie et remodelage cardiovasculaires
• Publié dans Circulation le 29/10/2020

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Résumé : Background- Protease nexin-1 (PN-1) is a serpin that inhibits plasminogen activators, plasmin, and thrombin. PN-1 is barely detectable in plasma, but we have shown recently that PN-1 is present within the α-granules of platelets. Methods and Results- In this study, the role of platelet PN-1 in fibrinolysis was investigated with the use of human platelets incubated with a blocking antibody and platelets from PN-1-deficient mice. We showed by using fibrin-agar zymography and fibrin matrix that platelet PN-1 inhibited both the generation of plasmin by fibrin-bound tissue plasminogen activator and the activity of fibrin-bound plasmin itself. Rotational thromboelastometry and laser scanning confocal microscopy were used to demonstrate that PN-1 blockade or deficiency resulted in increased clot lysis and in an acceleration of the lysis front. Protease nexin-1 is thus a major determinant of the lysis resistance of platelet-rich clots. Moreover, in an original murine model in which thrombolysis induced by tissue plasminogen activator can be measured directly in situ, we observed that vascular recanalization was significantly increased in PN-1-deficient mice. Surprisingly, general physical health, after tissue plasminogen activator-induced thrombolysis, was much better in PN-1-deficient than in wild-type mice. Conclusions- Our results reveal that platelet PN-1 can be considered as a new important regulator of thrombolysis in vivo. Inhibition of PN-1 is thus predicted to promote endogenous and exogenous tissue plasminogen activator-mediated fibrinolysis and may enhance the therapeutic efficacy of thrombolytic agents.

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Fichiers liés : revised-circulation-2010-000885.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/03/2011
• Auteurs : Jean-Mathias GriessmeierMichel TaggerPhilippe Zarka
• Organismes : Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Observatoire de Paris Laboratoire d'études spatiales et d'instrumentation en astrophysique

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Résumé : LOFAR is the first radiotelescope of a new generation, which can be described as "software telescopes". Observing between 15 and 240 MHz, the main complexity of LOFAR does not lie in the receivers (crossed, active dipoles), but in the hierarchical organisation of a large number of antennae (almost 50000) and in the analysis of the incoming data in a large computing facility. Rather than mechanically steering the telescope, pointing occurs fully numerically, and all observations are pre-processed on the fly to obtain a reasonable data volume. LOFAR will be 10 to 100 times more sensitive than the current instruments in the same frequency range. It will achieve sub-arcsecond resolution, which is 10 to 100 times better than the resolution of existing low-frequency instruments. It is also one of the most flexible instruments, making it interesting for a large number of scientific fields.

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Fichiers liés : 000039.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/03/2011
• Auteurs : Antoine RoquillyPierre Joachim MahePhilippe SeguinChristophe GuittonHervé FlochAnne Charlotte TellierLaurent MersonBenoît RenardYannick MalledantLaurent FletVéronique SébilleChristelle VolteauDamien MassonJean-Michel NguyenCorinne LejusKarim Asehnoune
• Organismes : Service d'anesthésie réanimation chirurgicale [Rennes] Foie, métabolismes et cancer Service de Réanimation Médicale Service d'anesthésie réanimation chirurgicale [Rennes] Foie, métabolismes et cancer Biostatistique, pharmacoépidémiologie et mesures subjectives en santé Service d'anesthésie et réanimation chirurgicale [Nantes]
• Publié dans Journal of the American Medical Association le 01/11/2020

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Résumé : CONTEXT: The role of stress-dose hydrocortisone in the management of trauma patients is currently unknown. OBJECTIVE: To test the efficacy of hydrocortisone therapy in trauma patients. DESIGN, SETTING, AND PATIENTS: Multicenter, randomized, double-blind, placebo-controlled HYPOLYTE (Hydrocortisone Polytraumatise) study. From November 2006 to August 2009, 150 patients with severe trauma were included in 7 intensive care units in France. INTERVENTION: Patients were randomly assigned to a continuous intravenous infusion of either hydrocortisone (200 mg/d for 5 days, followed by 100 mg on day 6 and 50 mg on day 7) or placebo. The treatment was stopped if patients had an appropriate adrenal response. MAIN OUTCOME MEASURE: Hospital-acquired pneumonia within 28 days. Secondary outcomes included the duration of mechanical ventilation, hyponatremia, and death. RESULTS: One patient withdrew consent. An intention-to-treat (ITT) analysis included the 149 patients, a modified ITT analysis included 113 patients with corticosteroid insufficiency. In the ITT analysis, 26 of 73 patients (35.6%) treated with hydrocortisone and 39 of 76 patients (51.3%) receiving placebo developed hospital-acquired pneumonia by day 28 (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.30-0.83; P = .007). In the modified ITT analysis, 20 of 56 patients (35.7%) in the hydrocortisone group and 31 of 57 patients (54.4%) in the placebo group developed hospital-acquired pneumonia by day 28 (HR, 0.47; 95% CI, 0.25-0.86; P = .01). Mechanical ventilation-free days increased with hydrocortisone by 4 days (95% CI, 2-7; P = .001) in the ITT analysis and 6 days (95% CI, 2-11; P < .001) in the modified ITT analysis. Hyponatremia was observed in 7 of 76 (9.2%) in the placebo group vs none in the hydrocortisone group (absolute difference, -9%; 95% CI, -16% to -3%; P = .01). Four of 76 patients (5.3%) in the placebo group and 6 of 73 (8.2%) in the hydrocortisone group died (absolute difference, 3%; 95% CI, -5% to 11%; P = .44). CONCLUSION: In intubated trauma patients, the use of an intravenous stress-dose of hydrocortisone, compared with placebo, resulted in a decreased risk of hospital-acquired pneumonia. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00563303.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/03/2011
• Auteurs : Pierre FormontNicolas TrouvéJean-Philippe OvarlezFrédéric PascalGabriel VasileElise Colin-Koeniguer
• Organismes : Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) ONERA - The French Aerospace Lab [Palaiseau] ONERA - The French Aerospace Lab [Toulouse] Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) GIPSA - Signal Images Physique ONERA - The French Aerospace Lab [Palaiseau]

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Résumé : Polarimetry has been studied for many years in SAR. Due to the enormous quantity of SAR images acquired by satellites or airborne systems, there is an evident need for efficient automatic analysis tools. Classification algorithms are one of the main applications for PoLSAR data. Nowadays, fully polarimetric high resolution sensors can commonly reach up to decimeter resolutions. This yields a higher heterogeneity in the clutter, especially in urban areas, where the clutter can no longer be modeled as a Gaussian process. Recent advances in the field of SIRV (Spherically Invariant Random Vectors) allow the modeling of non-Gaussian clutter as a compound Gaussian process. In this paper, we propose to apply a region growing process as an initialization to a SIRV based classification technique. As the region growing process is shape constrained, spatial features are better delineated and the samples used for the estimation of the coherency matrices are more adapted. Then a statistical clustering technique adapted to the SIRV model is applied to retrieve similarities between regions in the whole image.

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Fichiers liés : p51_formon.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/03/2011
• Auteurs : Mickaël PardéWigneron J.-P.Mehrez ZribiYann H. KerrPascal FaniseJean-Christophe CalvetClément AlbergelAhmad Al BitarFrançois CabotFrançois DemontouxElsa JacquetteErnesto Lopez-BaezaArnaud MialonChristophe MoisyNathalie NovelloPhilippe RichaumeKauzar Saleh ContellMike SchwankPhilippe WaldteufelElena ZakharovaMonique Dechambre
• Organismes : ESTER - LATMOS Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère ESTER - LATMOS Centre national de recherches météorologiques Centre national de recherches météorologiques Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Universitat de València = University of Valencia = Universidade de Valencia Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère University of Cambridge [Cambridge, UK] Centre d'études spatiales de la biosphère ESTER - LATMOS Centre national de recherches météorologiques ESTER - LATMOS

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Fichiers liés : Pardé-PIERS-2011_1

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• Type de publi. : Article dans une revue
• Date de publi. : 18/03/2011
• Auteurs : Mathias LefortFouzia BoulmedaisLoïc JierryEric GonthierJean-Claude VoegelJoseph HemmerléPhilippe LavalleArnaud PonchePierre Schaaf
• Organismes : Institut Charles Sadron Institut Charles Sadron Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Institut de Science des Matériaux de Mulhouse Biomatériaux et Bioingénierie
• Publié dans Langmuir le 27/10/2020

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Résumé : Simultaneous spraying of two solutions of interacting species onto a substrate held vertically leads to the formation of nanometer-sized coatings. Here we investigate the simultaneous spraying of poly(styrene sulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) solutions leading to the formation of a film composed of PSS/PAH complexes. The thickness of this film increases linearly with the cumulative spraying time. For a given spraying rate of PAH (respectively PSS), the growth rate of the film depends strongly upon the PSS/PAH ratio and passes through a maximum for a PSS/PAH ratio lying between 0.55 and 0.8. For a PSS/PAH ratio that is maintained constant, the growth speed of the film increases linearly with the spraying rate of polyelectrolyte of both solutions. Using X-ray photoelectron spectroscopy, we find that the film composition is almost independent of the PSS/PAH (spayed) ratio, with composition very close to 1:1 in PSS:PAH film. The 1:1 PSS:PAH composition is explained by the fact that the simultaneous spraying experiments are carried out with salt-free solutions; thus, electroneutrality in the film requires exact matching of the charges carried by the polyanions and the polycations. Zeta potential measurements reveal that, depending on whether the PSS/PAH spraying rate ratio lies below or above the optimal spraying rate ratio, the film acquires a positive or a negative excess charge. We also find that the overall film morphology, investigated by AFM, is independent of the spraying rate ratio and appears to be composed of nanometer-sized grains which are typically in the 100 nm range.

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