Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/03/2011
• Auteurs : Mickaël PardéWigneron J.-P.Mehrez ZribiYann H. KerrPascal FaniseJean-Christophe CalvetClément AlbergelAhmad Al BitarFrançois CabotFrançois DemontouxElsa JacquetteErnesto Lopez-BaezaArnaud MialonChristophe MoisyNathalie NovelloPhilippe RichaumeKauzar Saleh ContellMike SchwankPhilippe WaldteufelElena ZakharovaMonique Dechambre
• Organismes : ESTER - LATMOS Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère ESTER - LATMOS Centre national de recherches météorologiques Centre national de recherches météorologiques Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Universitat de València = University of Valencia = Universidade de Valencia Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Écologie fonctionnelle et physique de l'environnement Centre d'études spatiales de la biosphère University of Cambridge [Cambridge, UK] Centre d'études spatiales de la biosphère ESTER - LATMOS Centre national de recherches météorologiques ESTER - LATMOS

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Fichiers liés : Pardé-PIERS-2011_1

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• Type de publi. : Article dans une revue
• Date de publi. : 18/03/2011
• Auteurs : Mathias LefortFouzia BoulmedaisLoïc JierryEric GonthierJean-Claude VoegelJoseph HemmerléPhilippe LavalleArnaud PonchePierre Schaaf
• Organismes : Institut Charles Sadron Institut Charles Sadron Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Biomatériaux et Bioingénierie Institut de Science des Matériaux de Mulhouse Biomatériaux et Bioingénierie
• Publié dans Langmuir le 27/10/2020

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Résumé : Simultaneous spraying of two solutions of interacting species onto a substrate held vertically leads to the formation of nanometer-sized coatings. Here we investigate the simultaneous spraying of poly(styrene sulfonate) (PSS) and poly(allylamine hydrochloride) (PAH) solutions leading to the formation of a film composed of PSS/PAH complexes. The thickness of this film increases linearly with the cumulative spraying time. For a given spraying rate of PAH (respectively PSS), the growth rate of the film depends strongly upon the PSS/PAH ratio and passes through a maximum for a PSS/PAH ratio lying between 0.55 and 0.8. For a PSS/PAH ratio that is maintained constant, the growth speed of the film increases linearly with the spraying rate of polyelectrolyte of both solutions. Using X-ray photoelectron spectroscopy, we find that the film composition is almost independent of the PSS/PAH (spayed) ratio, with composition very close to 1:1 in PSS:PAH film. The 1:1 PSS:PAH composition is explained by the fact that the simultaneous spraying experiments are carried out with salt-free solutions; thus, electroneutrality in the film requires exact matching of the charges carried by the polyanions and the polycations. Zeta potential measurements reveal that, depending on whether the PSS/PAH spraying rate ratio lies below or above the optimal spraying rate ratio, the film acquires a positive or a negative excess charge. We also find that the overall film morphology, investigated by AFM, is independent of the spraying rate ratio and appears to be composed of nanometer-sized grains which are typically in the 100 nm range.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/03/2011
• Auteurs : Caroline Le GuinerMarie-Françoise MontusLaurent ServaisLuis GarciaYves FromesJean-Yves HogrelPierre CarlierYan CherelPhilippe P. MoullierThomas Voit
• Organismes : Généthon Institut National de la Santé et de la Recherche Médicale Généthon Institut de Myologie Institut de Myologie Généthon Institut de Myologie Institut de Myologie Institut de Myologie Développement et Pathologie du Tissu Musculaire Généthon Institut National de la Santé et de la Recherche Médicale Institut de Myologie

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Résumé : In Duchenne Muscular Dystrophy (DMD) the selective removal by exon skipping of exons anking an out-of frame mutation in the dystrophin messenger can result in in-frame mRNA transcripts that are translated into shorter but functionally active dystrophin. The goal of our project was to determine in GRMD, the effective dose of our therapeutic product de ned as a recombinant Adeno-Associated Virus serotype 8 (rAAV8) expressing a modified U7 snRNA speci c for the skipping of exons 5 to 10 of the GRMD dystrophin transcript. The mode of delivery was the locoregional high-pressure intravenous (IV) injection of a forelimb. Several groups of GRMD dogs were exposed to different rAAV8-U7snRNA doses. Each dog was followed ∼3 months after injection. The primary outcomes were the restoration of dystrophin expression and the improvement of the tissue pathology in the injected limb compared to the controlateral limb. The secondary outcomes were the muscle strength correction, the biodistribution and shedding patterns as well as the immune response against rAAV8 capsid and dystrophin. Our preliminary results suggest a dose effect of our therapeutic rAAV. Injection of 2,5E13vg/kg and of 5E12vg/kg of our vector was able to restore 50 to 80% of Dystrophin expression in the injected limb. This expression of a semi-functional dystrophin resulted in improvement of tissue morphology as well as of several functional and MRI parameters. No tissue in ammation occurred following the procedure. We built a unique network of laboratories with complementary skills to deliver a GLP-compliant set of preclinical data to further de ne the regulatory toxicology studies. The organization of our network and the results obtained in our GRMD dogs study will be presented. This project is supported by AFM (Association Française contre les Myopathies) and by ADNA (Advanced Diagnostics for New Therapeutic Approaches), a program dedicated to personalized medicine, coordinated by Institut Mérieux and supported by research and innovation aid from the French public agency, OSEO.

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Fichiers liés : 2011 Le Guiner_1.pdf

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• Type de publi. :
• Date de publi. : 16/03/2011
• Auteurs : Serge BorelPhilippe ChagnotJean-Pierre HamelHedi SellamiDabiel Perpezat
• Organismes : Centre de Géosciences

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Résumé : The machine (100) has a cutting head (24) mounted at a lower end of a vertical frame (22). The head comprises a support plate (40) carrying rotary cutting assemblies (26, 28) having parallel rotational axes, where each assembly is provided with two drums. A suction device (34) is connected to a suction nozzle (30) for evacuating spoil earth excavated by the drums. A deflector (200) is arranged above the suction nozzle and attached to the support plate to form a skirt extending laterally on the periphery of the plate to cover one of the drums

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2011
• Auteurs : Marie ThabardOlivier GrosClaire HellioJean-Philippe Maréchal
• Organismes : School of Biological Sciences Observatoire du milieu marin martiniquais Systématique, adaptation, évolution School of Biological Sciences Observatoire du milieu marin martiniquais
• Publié dans Botanica Marina le 29/10/2020

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Résumé : Coral reefs have undergone profound ecological changes over recent decades. Areas formerly covered by scleractinian coral species are now often overgrown by macroalgae. In Martinique (West Indies), this phenomenon has lead to the colonisation of numerous coral reefs by algae, amongst which Sargassum is one of the most prominent. This study focuses on potential defence molecules produced by Sargassum polyceratium. The hexane dipping method was employed to extract surface molecules on fresh material, and their bioactivities were assessed against bacteria (marine and estuarine), and marine tropical invertebrates wan annelid (Pseudonereis sp.), a bivalve (Codakia orbicularis) and a sea urchin (Diadema antillarum)x. Extracts were active against all microorganisms tested (MICs150 or 300 mg ml-1), early stages of development in Pseudonereis sp. (MICs100 mg ml-1) and embryos of C. orbicularis and D. antillarum (MICs5 mg ml-1), suggesting the production of defence compounds by S. polyceratium.

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Fichiers liés : Publication_Sargassum_bortanica_marina.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 14/03/2011
• Auteurs : Stéphanie TruantD. IzgarevicVincent MaunouryDavid BuobPhilippe BuloisOlivier ErnstGuillemette HuetPhilippe ZerbibFrançois-René Pruvot
• Organismes : Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 GASTROENTEROLOGY CHU Tenon [AP-HP] Institut National de la Santé et de la Recherche Médicale Radiologie interventionnelle Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Service de Biologie Moléculaire et Centre de Pathologie Digestive Surgery and Transplantation Digestive Surgery and Transplantation
• Publié dans HPB Surgery le 23/06/2021

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Résumé : Serous cystadenoma is a common benign neoplasm that can be managed without surgery in asymptomatic patients provided that the diagnosis is certain. We describe a patient, whose pancreatic cyst exhibited a radiological appearance distinct from that of typical serous cystadenoma, resulting in diagnostic difficulties. CT and MRI showed a 10 cm-polycystic tumor with upstream dilatation of the main pancreatic duct (MPD), suggestive of intraductal papillary mucinous tumor (IPMT). Ultrasonographic aspect and EUS-guided fine-needle aspiration gave arguments for serous cystadenoma. ERCP showed a communication between cysts and the dilated MPD, compatible with IPMT. The patient underwent left pancreatectomy with splenectomy. Pathological examination concluded in a serous cystadenoma, with only a ductal obstruction causing proximal dilatation.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/03/2011
• Auteurs : Nicolas WlodarczykDelphine Le Broc-RyckewaertPauline GilleronAmélie LemoineAmaury FarcePhilippe ChavatteJoëlle DuboisNicole PommeryJean-Pierre HénichartChristophe FurmanRégis Millet
• Organismes : Institut de Chimie des Substances Naturelles
• Publié dans Journal of Medicinal Chemistry le 25/10/2020

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Résumé : A new class of potent farnesyltransferase inhibitors based on a 1,4-diazepane scaffold was synthesized with protein farnesyltransferase inhibition potencies in the low nanomolar range. The compounds block the growth on two hormone-resistant tumor prostatic cell lines (DU145 and PC3). The advanced cellular evaluation of the more potent farnesyltransferase inhibitors was explored and revealed a disorganization of tubulin in PC3 cells.

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• Type de publi. :
• Date de publi. : 10/03/2011
• Auteurs : Maëlenn GuerchetAlain Maxime MouangaPascal M'BelessoAndré TaboBébène Ndamba-BandzouziJean-Pierre ClémentPhilippe LacroixPierre-Marie PreuxVictor Aboyans
• Organismes : Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Neuroépidémiologie Tropicale Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Neuroépidémiologie Tropicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Neuroépidémiologie Tropicale

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• Type de publi. : Article dans une revue
• Date de publi. : 07/03/2011
• Auteurs : François GerbeJohan van EsLeila MakriniBénédicte BrulinGeorg MellitzerSylvie RobineBéatrice RomagnoloNoah F. ShroyerJean-François BourgauxChristine PignodelHans CleversPhilippe Jay
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génétique et de Biologie Moléculaire et Cellulaire Compartimentation et dynamique cellulaires Institut Cochin Division of Gastroenterology, Hepatology and Nutrition Centre Hospitalier Universitaire de Nîmes Service d'Anatomopathologie Hubrecht Institute for Developmental Biology and Stem Cell Research Institut de Génomique Fonctionnelle
• Publié dans Journal of Cell Biology le 02/11/2020

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Fichiers liés : jcb_201010127.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/03/2011
• Auteurs : Pierre CarpentierJean-Philippe ChancelierGuy Cohen
• Organismes : Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique

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Résumé : 1 Problem formulation 2 Modeling improvement 3 Stochastic Arrow-Hurwicz algorithm 4 Numerical results

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Fichiers liés : CARPENTIER.pdf

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