Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 17/02/2011
• Auteurs : Stefano TargettiDavide ViaggiDavid CumingJean-Pierre SarthouJean-Philippe Choisis
• Organismes : Alma Mater Studiorum Università di Bologna = University of Bologna Alma Mater Studiorum Università di Bologna = University of Bologna Alma Mater Studiorum Università di Bologna = University of Bologna Dynamiques Forestières dans l'Espace Rural École nationale supérieure agronomique de Toulouse Dynamiques Forestières dans l'Espace Rural

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Résumé : A comprehensive quantification of biodiversity in farming systems would require a very significant amount of work (and funds) even for a small area. Therefore, biodiversity indicators are needed to solve the problem of the measurement feasibility. Even though the issue of cost and effectiveness is central for the evaluation of the indicators, only the latter is discussed in detail in the scientific literature. This work presents a cost analysis based on the direct gathering of records from a farm-scale biodiversity survey (EU-FP7, BioBio - “Indicators for biodiversity in organic and low-input farming systems”) where the analysis of costs is part of the project. It is a simple method for comparing different indicators by their ratio of cost/effectiveness. Here we present the results from the French case study (Gascony Hills, Midi-Pyrenees Region).

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Fichiers liés : 2011_Targetti_EAAE_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/02/2011
• Auteurs : Tabassome SimonPhilippe Gabriel StegMartine GilardDidier BlanchardLaurent BonelloMichel HanssenHervé LardouxPierre CosteThierry LefèvreElodie DrouetGeneviève MulakVincent BatailleJean FerrièresCéline VerstuyftNicolas Danchin
• Organismes : Service de cardiologie Hémostase, bio-ingénierie et remodelage cardiovasculaires Optimisation des régulations physiologiques CHU Saint-Antoine [AP-HP] Service Cardiologie [CHU Toulouse] Service de génétique moléculaire, pharmacogénétique et hormonologie Service de Cardiologie [CHU Rouen]
• Publié dans Circulation le 29/10/2020

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Résumé : BACKGROUND: Clopidogrel requires metabolic activation by cytochrome P450 2C19 (CYP2C19). Proton pump inhibitors (PPIs) that inhibit CYP2C19 are commonly coadministered with clopidogrel to reduce the risk of gastrointestinal bleeding. This analysis compares treatment outcomes for patients in the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) who did or did not receive clopidogrel and/or PPIs. METHODS AND RESULTS: The FAST-MI registry included 3670 patients (2744 clopidogrel- and PPI-naïve patients) presenting with definite MI. Patients were categorized according to use of clopidogrel and/or PPI within 48 hours after hospital admission. PPI use was not associated with an increased risk for any of the main in-hospital events (in-hospital survival, reinfarction, stroke, bleeding, and transfusion). Likewise, PPI treatment was not an independent predictor of 1-year survival (hazard ratio, 0.97; 95% confidence interval [CI], 0.87 to 1.08; P=0.57) or 1-year MI, stroke, or death (hazard ratio, 0.98; 95% CI, 0.90 to 1.08; P=0.72). No differences were seen when the type of PPI or CYP2C19 genotype was taken into account. In the propensity-matched cohorts, the odds ratios for major in-hospital events in PPI versus no PPI were 0.29 (95% CI, 0.06 to 1.44) and 1.70 (95% CI, 0.10 to 30.3) for patients with 1 and 2 variant alleles, respectively. Similarly, the hazard ratio for 1-year events in hospital survivors was 0.68 (95% CI, 0.26 to 1.79) and 0.55 (95% CI, 0.06 to 5.30), respectively. CONCLUSION: PPI use was not associated with an increased risk of cardiovascular events or mortality in patients administered clopidogrel for recent MI, whatever the CYP2C19 genotype, although harm could not be formally excluded in patients with 2 loss-of-function alleles.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/02/2011
• Auteurs : Fabien ViallaCyrielle RoqueletChristophe VoisinJean‐sébastien LauretPhilippe RoussignolEmmanuelle Deleporte
• Organismes : Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire

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Résumé : The chemical functionalization of single-wall nanotubes (SWNTs) with dye molecules is a promising way for combining the exceptional transport properties of the nanotube and the tunability of optical properties of the chromophores in view of future carbon-based applications such as photovoltaic and other optoelectronic nanodevices. -stacking functionalization of porphyrin (TPP) molecules using a micelle swelling method was achieved recently, yielding stable and reproducible compounds [1]. Photoluminescence (PL) measurements on ensembles of such complexes evidenced a soft enough functionalization so to preserve the intrinsic properties of NTs, and yet an e cient energy transfer from the TPP to the NT [2]. In the view of overcoming the inhomogeneous e ects of ensembles studies, we report here on preliminary investigations of PL properties of such molecular assemblies at the scale of a single object lying on a quartz substrate. We run confocal spectroscopy with a HeNe laser (633 nm) excitation corresponding to the S22 transition energy of (6,4) NTs and observe spatially localized and linearly polarized light emissions. PL spectra show single peaks corresponding to the S11 transition of the minority chirality (6,4) of the sample. This brings evidence for single NTs as emitters. Further investigations are in progress, introducing the variation of the temperature, the wavelength and polarization of the excitation light, coupled with AFM imaging. That will lead to a better understanding of both structural (in uence of the substrate, surface coverage of the NT by the TPP) and optoelectronic (spectral shifts, transfer mechanisms) properties of the complex. References [1] C. Roquelet, ChemPhysChem 2010, 11, 1667-1672.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/02/2011
• Auteurs : Dmitry LevshovThierry MichelY. YuzyukChristophe VoisinLaurent AlvarezSébastien BergerPhilippe RoussignolJean-Louis Sauvajol
• Organismes : Faculty of Physics Laboratoire Charles Coulomb Faculty of Physics Laboratoire Pierre Aigrain Laboratoire Charles Coulomb Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Charles Coulomb

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Résumé : The temperature dependence of the Raman spectrum of a gelatine-based composite material doped with single-walled carbon nanotubes (SWNT@gelatin) is reported [1]. A significant up-shift of the G-mode frequency is observed when the temperature is decreased from room temperature to 20 K. This frequency shift is significantly stronger than the one found for pure thermal effects. In contrast, the features of the radial breathing modes (frequencies and width) display no significant change in the same temperature range. These results are well understood by considering a uniaxial strain on the nanotube induced by the thermal expansitivity mismatch between the nanotube and the surrounding matrix [2,3]. These conclusions are in good agreement with photoluminescence experiments performed on the same samples [4]. References [1] D. Levshov, J. Phys. Chem. C 2010, 114, 16210-16214. [2] S. Cronin, Phys. Rev. Lett. 2004, 93, 167401. [3] G. Wu, Phys. Rev. B 2005, 72, 115411. [4] S. Berger, J. Appl. Phys. 2009, 105, 094323.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/02/2011
• Auteurs : Adrien BrilhaultSlim KammounOlivier GutierrezPhilippe TruilletChristophe Jouffrais
• Organismes : Etude de L’Interaction Personne SystèmE Etude de L’Interaction Personne SystèmE Etude de L’Interaction Personne SystèmE Etude de L’Interaction Personne SystèmE Centre National de la Recherche Scientifique Etude de L’Interaction Personne SystèmE Image & Pervasive Access Lab Laboratoire Cherchons Pour Voir

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• Type de publi. : Article dans une revue
• Date de publi. : 07/02/2011
• Auteurs : Grégory MollionPhilippe Yolka
• Organismes : Centre de Recherches Juridiques Centre d'Etudes et de Recherches sur le Droit, l'Histoire et l'Administration Publique
• Publié dans La Semaine Juridique. Administrations et collectivités territoriales le 23/10/2020

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Résumé : Par une décision du 22 octobre 2010 concernant les suites de l'avalanche de Montroc (Chamonix, février 1999), le Conseil d'État annule un arrêt d'appel aux termes duquel les fautes alléguées n'entretenaient pas de lien direct avec le préjudice invoqué. Ce faisant, il invite la juridiction de renvoi à rechercher l'existence éventuelle d'une faute commise par l'administration lors du classement du secteur concerné en zone constructible

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/02/2011
• Auteurs : Benjamin LangloisDamien GarrotCyrielle RoqueletChristophe VoisinJean‐sébastien LauretThierry MichelPhilippe RoussignolClaude DelalandeEmmanuelle Deleporte
• Organismes : Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire Charles Coulomb Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire

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Résumé : Single-Wall Carbon Nanotubes (SWNTs) non-covalently functionalized with organic molecules have proven to be a very promising light-harvesting system. The goal is to combine the unique transport and optical properties of nanotubes with the wide tunability of organic molecules properties. Among those molecules, porphyrins, a precursor of photosynthetic centers, show a strong absorption in the visible that is already used in dye sensitized hybrid solar cells [1]. Porphyrins link to SWNTs through π-stacking interaction which preserves most of the intrinsic properties of the SWNTs, in contrast with covalent functionalization. Moreover, the coupling is still strong enough to induce new functionalities. It was recently shown that efficient excitation energy transfer (EET) can occur in such system [2,3]. The very high quantum yield reported in this system suggests that the EET mechanism must occur on an ultrafast time-scale [4]. In order to characterize the nature of the EET mechanism, we investigate its dynamics at a subpicosecond time scale, by means of pump-probe spectroscopy. We show that the ground state recovery time of porphyrin in the compound is reduced by several orders of magnitude compared to the case or free porphyrin (Fig. 1). Concomitantly, a strong bleaching signal is observed on the optical resonances of the nanotubes showing an ultrafast population build-up upon excitation of the porphyrin (Fig. 2). We conclude that the energy transfer occurs on a time scale shorter than 100fs and that the surrounding of SWNTs by porphyrins does not affect the relaxation dynamics. References [1] W. M. Campbell, et al., The Journal of Physical Chemistry C, 111, 11760 (2007). [2] G. Magadur, et al., ChemPhysChem, 9, 1250 (2008).pp. 200-205. [3] J. P. Casey, et al., Journal of Materials Chemistry, 18, 1510 (2008). [4] C. Roquelet, et al., Applied Physics Letters, 97, 141918 (2010).

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/02/2011
• Auteurs : Cyrielle RoqueletDamien GarrotJean‐sébastien LauretChristophe VoisinValérie AlainPhilippe RoussignolJacques A. DelaireEmmanuelle Deleporte
• Organismes : Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire Pierre Aigrain Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Institut d'Alembert Laboratoire de Photonique Quantique et Moléculaire

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• Type de publi. : Article dans une revue
• Date de publi. : 03/02/2011
• Auteurs : Marion LudwigNuno PalhaCorinne C. TorhyValérie BriolatEmma Colucci-GuyonMichel BrémontPhilippe HerbomelPierre BoudinotJean-Pierre Levraud
• Organismes : Macrophages et Développement de l'Immunité Macrophages et Développement de l'Immunité Unité de recherche Virologie et Immunologie Moléculaires Macrophages et Développement de l'Immunité Macrophages et Développement de l'Immunité Unité de recherche Virologie et Immunologie Moléculaires Macrophages et Développement de l'Immunité Unité de recherche Virologie et Immunologie Moléculaires Macrophages et Développement de l'Immunité
• Publié dans PLoS Pathogens le 27/10/2020

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Résumé : The progression of viral infections is notoriously difficult to follow in whole organisms. The small, transparent zebrafish larva constitutes a valuable system to study how pathogens spread. We describe here the course of infection of zebrafish early larvae with a heat-adapted variant of the Infectious Hematopoietic Necrosis Virus (IHNV), a rhabdovirus that represents an important threat to the salmonid culture industry. When incubated at 24 °C, a permissive temperature for virus replication, larvae infected by intravenous injection died within three to four days. Macroscopic signs of infection followed a highly predictable course, with a slowdown then arrest of blood flow despite continuing heartbeat, followed by a loss of reactivity to touch and ultimately by death. Using whole-mount in situ hybridization, patterns of infection were imaged in whole larvae. The first infected cells were detectable as early as 6 hours post infection, and a steady increase in infected cell number and staining intensity occurred with time. Venous endothelium appeared as a primary target of infection, as could be confirmed in fli1:GFP transgenic larvae by live imaging and immunohistochemistry. Disruption of the first vessels took place before arrest of blood circulation, and hemorrhages could be observed in various places. Our data suggest that infection spread from the damaged vessels to underlying tissue. By shifting infected fish to a temperature of 28 °C that is non-permissive for viral propagation, it was possible to establish when virus-generated damage became irreversible. This stage was reached many hours before any detectable induction of the host response. Zebrafish larvae infected with IHNV constitute a vertebrate model of an hemorrhagic viral disease. This tractable system will allow the in vivo dissection of host-virus interactions at the whole organism scale, a feature unrivalled by other vertebrate models.

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Fichiers liés : Whole-Body Analysis of a Viral Infection Vascular Endothelium is a Primary Target.PDF

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• Type de publi. : Article dans une revue
• Date de publi. : 02/02/2011
• Auteurs : Olivia BoyerGeneviève BenoitOlivier GribouvalFabien NevoMarie-Josèphe TêteJacques DantalBrigitte Gilbert-DussardierGuy TouchardAlexandre KarrasClaire PresneJean-Pierre GrünfeldChristophe LegendreDominique JolyPhilippe RieuNabil MohsinThierry HannedoucheValerie MoalMarie-Claire GublerIsabelle BroutinGéraldine MolletCorinne Antignac
• Organismes : Néphropathies héréditaires et rein en développement Néphropathies héréditaires et rein en développement Néphropathies héréditaires et rein en développement Neuropathies héréditaires et rein en développement Service de néphrologie pédiatrique [CHU Necker] Unit of Nephrology & Clinical Immunology Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Service de Néphrologie [CHU Poitiers] Service de Néphrologie [HEGP] Service de Néphrologie [Amiens] Service de néphrologie pédiatrique [CHU Necker] Service de néphrologie adultes [CHU Necker] Évolution, génomes, comportement et écologie Hôpital universitaire Robert Debré [Reims] Sultan Qaboos University Department of Nephrology, Sun Yat-sen University Centre de néphrologie et transplantation rénale [Hôpital de la Conception - APHM] Neuropathies héréditaires et rein en développement Laboratoire de cristallographie et RMN biologiques Néphropathies héréditaires et rein en développement Néphropathies héréditaires et rein en développement
• Publié dans Journal of the American Society of Nephrology le 26/10/2020

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