Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 20/01/2011
• Auteurs : Andrea LowTim ClaytonIssouf KonatéNicolas NagotAbdoulaye OuedraogoCharlotte HuetMarie-Noelle Didelot-RousseauMichel SegondyPhilippe van de PerrePhilippe MayaudEloi BahemberaAbdramane BerthéeMinata CoulibalyMarie-Christine DeferRamata DialloDidier DjagbaréFlorent Ky-DamaGilles T. M’boutikiNicolas MedaInès MillogoDjénéba OuédraogoFrançois RouetAnselme SanonHaoua SawadogoR. ValloLaurence VergneHelen A WeissPierre BecquartVincent FoulongneJean-Baptiste AndonabaAdrien Sawadogo
• Organismes : London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine Centre Muraz [Bobo-Dioulasso, Burkina Faso] Pathogénèse et contrôle des infections chroniques (PCCI) Département d'Information Médicale [CHU Montpellier] Laboratoire de Virologie [CHRU Montpellier] London School of Hygiene and Tropical Medicine Centre Muraz [Bobo-Dioulasso, Burkina Faso] London School of Hygiene and Tropical Medicine Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Pathogénèse et contrôle des infections chroniques (PCCI) Département d'Information Médicale [CHU Montpellier] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Département d'Information Médicale [CHU Montpellier] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Département d'Information Médicale [CHU Montpellier] Laboratoire de Virologie [CHRU Montpellier] Centre Muraz [Bobo-Dioulasso, Burkina Faso] London School of Hygiene and Tropical Medicine Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] Centre Muraz [Bobo-Dioulasso, Burkina Faso] London School of Hygiene and Tropical Medicine Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Centre Hospitalier Universitaire Souro Sanou [Bobo-Dioulasso] Centre Hospitalier Universitaire Souro Sanou [Bobo-Dioulasso]
• Publié dans BMC Infectious Diseases le 01/11/2020

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Résumé : Background : Human papillomaviruses are the most common sexually transmitted infections, and genital warts, caused by HPV-6 and 11, entail considerable morbidity and cost. The natural history of genital warts in relation to HIV-1 infection has not been described in African women. We examined risk factors for genital warts in a cohort of high-risk women in Burkina Faso, in order to further describe their epidemiology. Methods : A prospective study of 765 high-risk women who were followed at 4-monthly intervals for 27 months in Burkina Faso. Logistic and Cox regression were used to identify factors associated with prevalent, incident and persistent genital warts, including HIV-1 serostatus, CD4+ count, and concurrent sexually transmitted infections. In a subset of 306 women, cervical HPV DNA was tested at enrolment. Results : Genital wart prevalence at baseline was 1.6% (8/492) among HIV-uninfected and 7.0% (19/273) among HIV-1 seropositive women. Forty women (5.2%) experienced at least one incident GW episode. Incidence was 1.1 per 100 person-years among HIV-uninfected women, 7.4 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count >200 cells/μL and 14.6 per 100 person-years among HIV-1 seropositive women with a nadir CD4+ count ≤200 cells/μL. Incident genital warts were also associated with concurrent bacterial vaginosis, and genital ulceration. Antiretroviral therapy was not protective against incident or persistent genital warts. Detection of HPV-6 DNA and abnormal cervical cytology were strongly associated with incident genital warts. Conclusions : Genital warts occur much more frequently among HIV-1 infected women in Africa, particularly among those with low CD4+ counts. Antiretroviral therapy did not reduce the incidence or persistence of genital warts in this population.

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Fichiers liés : 1471-2334-11-20.pdf

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 19/01/2011
• Auteurs : Peter SturmSrikumar RamalingamJean-Philippe TardifSimone GaspariniJoao Barreto
• Organismes : Interpretation and Modelling of Images and Videos Mitsubishi Electric Research Laboratories National Robotics Engineering Center [Carnegie Mellon] Interpretation and Modelling of Images and Videos Institute of Systems and Robotics

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Résumé : This survey is mainly motivated by the increased availability and use of panoramic image acquisition devices, in computer vision and various of its applications. Different technologies and different computational models thereof exist and algorithms and theoretical studies for geometric computer vision ("structure-from-motion") are often re-developed without highlighting common underlying principles. One of the goals of this survey is to give an overview of image acquisition methods used in computer vision and especially, of the vast number of camera models that have been proposed and investigated over the years, where we try to point out similarities between different models. Results on epipolar and multi-view geometry for different camera models are reviewed as well as various calibration and self-calibration approaches, with an emphasis on non-perspective cameras. We finally describe what we consider are fundamental building blocks for geometric computer vision or structure-from-motion: epipolar geometry, pose and motion estimation, 3D scene modeling, and bundle adjustment. The main goal here is to highlight the main principles of these, which are independent of specific camera models.

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Fichiers liés : sturm-ftcgv-2011.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 11/01/2011
• Auteurs : Sonja JanmaatYvette AkwaMohamed DoulazmiJoëlle BakoucheVanessa GautheronPhilippe LiereBernard EychenneAntoine PianosPaul LuitenTon GroothuisEtienne-Emile BaulieuJean MarianiRachel SherrardFlorence Frédéric
• Organismes : Neurobiologie des processus adaptatifs Stéroides et système nerveux : physiopathologie moléculaire et clinique Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs Stéroides et système nerveux : physiopathologie moléculaire et clinique Stéroides et système nerveux : physiopathologie moléculaire et clinique Stéroides et système nerveux : physiopathologie moléculaire et clinique Stéroides et système nerveux : physiopathologie moléculaire et clinique Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs Neurobiologie des processus adaptatifs
• Publié dans AGE le 26/10/2020

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Résumé : A major problem of ageing is progressive impairment of neuronal function and ultimately cell death. Since sex steroids are neuroprotective, their decrease with age may underlie age-related neuronal degeneration. To test this, we examined Purkinje cell numbers, plasma sex steroids and cerebellar neurosteroid concentrations during normal ageing (wild-type mice, WT), in our model of precocious ageing (Rora ( +/sg ), heterozygous staggerer mice in which expression of the neuroprotective factor RORα is disrupted) and after long-term hormone insufficiency (WT post-gonadectomy). During normal ageing (WT), circulating sex steroids declined prior to or in parallel with Purkinje cell loss, which began at 18 months of age. Although Purkinje cell death was advanced in WT long-term steroid deficiency, this premature neuronal loss did not begin until 9 months, indicating that vulnerability to sex steroid deficiency is a phenomenon of ageing Purkinje neurons. In precocious ageing (Rora ( +/sg )), circulating sex steroids decreased prematurely, in conjunction with marked Purkinje cell death from 9 months. Although Rora ( +/sg ) Purkinje cells are vulnerable through their RORα haplo-insufficiency, it is only as they age (after 9 months) that sex steroid failure becomes critical. Finally, cerebellar neurosteroids did not decrease with age in either genotype or gender; but were profoundly reduced by 3 months in male Rora ( +/sg ) cerebella, which may contribute to the fragility of their Purkinje neurons. These data suggest that ageing Purkinje cells are maintained by circulating sex steroids, rather than local neurosteroids, and that in Rora ( +/sg ) their age-related death is advanced by premature sex steroid loss induced by RORα haplo-insufficiency.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/01/2011
• Auteurs : Alain BousquetPhilippe JacquietHervé HosteJulien ClémentJean-Paul J.-P. BergeaudMichel AlvineriePierre‐louis Toutain
• Organismes : Physiologie et Toxicologie Expérimentales Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Interactions hôtes-agents pathogènes [Toulouse] Laboratoire de Pharmacologie et Toxicologie Physiologie et Toxicologie Expérimentales
• Publié dans Int J Parasitol le 01/01/2003

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Résumé : Licking behaviour in cattle has been reported to account for the disposition of topically administered macrocyclic lactones. However, its impact on anthelmintic efficacy remains to be established. Therefore, we evaluated the impact of ivermectin exchange between cattle on the reduction in the faecal egg count (FEC) after pour-on administration in a group of 10 heifers experimentally infected with Ostertagia ostertagi and Cooperia oncophora. Four treated (500 μg/kg, pour-on) and six untreated animals were put together after treatment and plasma and faecal exposure to ivermectin as well as the FECs were evaluated before and over 40 days after treatment. Ivermectin was detected in plasma and faeces of the six untreated heifers, with maximal exposures two- to three-fold lower than the minimal exposures in treated animals. The interindividual variability of exposure was very high in untreated animals, with a 10-fold difference between the upper and lower limits compared with treated heifers, where there was only a two-fold difference. Anthelmintic efficacy, expressed as an average reduction of the FECs over the experimental period, was maximal in the treated group. In untreated heifers, anthelmintic efficacies ranged from zero to maximal efficacy, with intermediary values between 30 and 80%. The use of a classical pharmacodynamic model demonstrated a clear relationship between exposure and efficacy and enabled us to define the critical plasma or faecal ivermectin concentrations delimiting an exposure window associated with partial anthelmintic efficacy. This range of ivermectin plasma concentrations (0.1-1 ng/mL) could be considered as a potential selection window for anthelmintic resistance. Finally, our results show that macrocyclic lactone exchange between cattle after pour-on administration, resulting from natural grooming behaviour, can significantly impact on anthelmintic efficacy. This raises several issues such as the design of comparative clinical trials and the occurrence of partial efficacy which is considered a risk factor for the development of anthelmintic resistance.

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Fichiers liés : Bousquet-Melou_Authors_Manuscript_IJP_2011.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 08/01/2011
• Auteurs : Michel DevyJean-Louis BoizardDiego BoteroHenry CarrilloMario IbarraZohir IrkiAbdelelah NaoulouPierre LacroixPhilippe FillatreauJean-Yves FourniolsCarlos Parra
• Organismes : Équipe Robotique, Action et Perception Laboratoire d'analyse et d'architecture des systèmes Service Instrumentation Conception Caractérisation Laboratoire d'analyse et d'architecture des systèmes

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Résumé : This chapter describes the development of an integrated stereovision sensor intended to be embedded on mobile platforms like robots or intelligent vehicles. Such a sensor is required for the motion control of these platforms. Navigation can be either autonomous (e.g. for a robot executing tasks in dangerous environments), or supervised by a human driver (typically for intelligent transportation systems).

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Fichiers liés : Devy_2011.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/01/2011
• Auteurs : Jean-Christophe VidelinPhilippe Yolka
• Organismes : Centre de Recherches Juridiques Centre d'Etudes et de Recherches sur le Droit, l'Histoire et l'Administration Publique
• Publié dans La Semaine Juridique. Administrations et collectivités territoriales le 23/10/2020

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Résumé : Est illégale la délibération par laquelle un conseil municipal décide la cession de parcelles d'un chemin rural, quand le maire était présent lors du vote alors qu'il est associé de la SCI bénéficiaire et qu'une procédure d'échange a été mise en œuvre.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Jean-Philippe SautAnis SahbaniVeronique Perdereau
• Organismes : Institut des Systèmes Intelligents et de Robotique Institut des Systèmes Intelligents et de Robotique Institut des Systèmes Intelligents et de Robotique
• Publié dans Advanced Robotics le 25/10/2020

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Résumé : This paper addresses the dexterous manipulation planning problem, which deals with motion planning for a multi-fingered hand manipulating objects among static obstacles, under quasi-static movement assumption. We propose a general manipulation approach able to compute object and finger trajectories, as well as the finger relocation sequence, in order to link any two given configurations of the composite system hand + object. It relies on a topological property that characterizes the existence of solutions in the subspace of configurations where the object is grasped by the n fingers. This property helps reduce the problem by structuring the search space. The developed planner captures in a probabilistic roadmap the connectivity of submanifolds of the composite configuration space. The answer to the manipulation planning query is then given by searching a path in the computed graph. Simulation experiments are reported for different multi-fingered manipulation task examples showing the efficiency of the proposed method.

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Fichiers liés : AR2011.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Magali RebucciPaul PeixotoAmélie DewitteNicole WattezMarie-Adeline de NuncquesNicolas RezvoyClaire Vautravers-DewasMarie-Pierre BuisineEric GuerinJean-Philippe PeyratEric LartigauAmélie Lansiaux
• Organismes : Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut pour la recherche sur le cancer de Lille [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Institut pour la recherche sur le cancer de Lille [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Institut pour la recherche sur le cancer de Lille [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut pour la recherche sur le cancer de Lille [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Faculté de Médecine Henri Warembourg - Université de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Physiopathologie et médecine translationnelle Laboratoire de Biochimie et de Biologie Moléculaire Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Faculté de Médecine Henri Warembourg - Université de Lille Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Institut pour la recherche sur le cancer de Lille [Lille] Faculté de Médecine Henri Warembourg - Université de Lille
• Publié dans International Journal of Oncology le 27/11/2023

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Résumé : EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC). Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce the downstream signaling pathways and induce EGFR internalization. This study aims to investigate the role of the EGFR signaling pathway and EGFR internalization in a cetuximab-resistant cell line and to propose a new therapeutic strategy to optimize treatment of HNSCC. The HNSCC cell line, CAL33 was sensitive to gefitinib but resistant to cetuximab. Cetuximab induces an unexpected EGFR phosphorylation in CAL33 cells similarly to EGF but this EGFR activation does not trigger EGFR internalization/degradation, the process currently implicated in the response to cetuximab. Cetuximab inhibits ERK and AKT phosphorylation in cetuximab-sensitive A431 cells, whereas the level of AKT phosphorylation is unmodified in cetuximab-resistant cells. Interestingly, CAL33 cells harbor a PIK3CA mutation. The treatment of CAL33 cells with PI3K inhibitor and cetuximab restores the inhibition of AKT phosphorylation and induces growth inhibition. Our results indicate that EGFR internalization is impaired by cetuximab treatment in CAL33 cells and that the AKT pathway is a central element in cetuximab resistance. The combination of cetuximab with a PI3K inhibitor could be a good therapeutic option in PIK3CA-mutated HNSCC.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Marie Potier-CartereauAurélie ChantômeVirginie JoulinAlban GiraultSébastien RogerPierre BessonMarie-Lise JourdanJean-Yves LeguennecPhilippe BougnouxChristophe Vandier
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Génomes et cancer Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif
• Publié dans British Journal of Pharmacology le 29/10/2020

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Résumé : BACKGROUND AND PURPOSE: The 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine (edelfosine) is an ether-linked phospholipid with promising anti-cancer properties but some side effects that preclude its full clinical therapeutic exploitation. We hypothesized that this lipid could interact with plasma membrane ion channels and modulate their function. EXPERIMENTAL APPROACH: Using cell migration-proliferation assays, patch clamp, spectrofluorimetry and ¹²⁵I-Apamin binding experiments, we studied the effects of edelfosine on the migration of breast cancer MDA-MB-435s cells, mediated by the small conductance Ca²(+) -activated K(+) channel, SK3/K(Ca)2.3. KEY RESULTS: Edelfosine (1 µM) caused plasma membrane depolarization by substantially inhibiting activity of SK3/K(Ca)2.3 channels, which we had previously demonstrated to play an important role in cancer cell migration. Edelfosine did not inhibit ¹²⁵I-Apamin binding to this SK(Ca) channel; rather, it reduced the calcium sensitivity of SK3/K(Ca)2.3 channel and dramatically decreased intracellular Ca²(+) concentration, probably by insertion in the plasma membrane, as suggested by proteinase K experiments. Edelfosine reduced cell migration to the same extent as known SK(Ca) channel blockers. In contrast, K+ channel openers prevented edelfosine-induced anti-migratory effects. SK3 protein knockdown decreased cell migration and totally abolished the effect of edelfosine on MDA-MB-435s cell migration. In contrast, transient expression of SK3/K(Ca)2.3 protein in a SK3/K(Ca)2.3-deficient cell line increased cell migration and made these cells responsive to edelfosine. CONCLUSIONS AND IMPLICATIONS: Our data clearly establish edelfosine as an inhibitor of cancer cell migration by acting on SK3/K(Ca)2.3 channels and provide insights into the future development of a new class of migration-targeted, anti-cancer agents.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Douglas J ParkerCyrille FlamantHartmut HöllerJan PolcherJean-Luc RedelspergerChris ThorncroftOlivier BockBernard BourlèsSylvie GalleBeatrice MarticorenaÉric MouginChristophe PeugeotBernard CappelaereLuc DescroixA. DiedhouAmadou T. GayeJean-Philippe LaforeThierry Lebel
• Organismes : TROPO - LATMOS DLR Institut für Physik der Atmosphäre = DLR Institute of Atmospheric Physics Laboratoire de Météorologie Dynamique (UMR 8539) Centre national de recherches météorologiques University at Albany [SUNY] LAboratoire de Recherche en Géodésie Laboratoire d'études en Géophysique et océanographie spatiales Laboratoire d'étude des transferts en hydrologie et environnement Laboratoire Interuniversitaire des Systèmes Atmosphériques Centre d'études spatiales de la biosphère Hydrosciences Montpellier Hydrosciences Montpellier Laboratoire d'étude des transferts en hydrologie et environnement Laboratoire d'étude des transferts en hydrologie et environnement Laboratoire de Physique de l'Atmosphère et de l'Océan Siméon Fongang Centre national de recherches météorologiques Laboratoire d'étude des transferts en hydrologie et environnement
• Publié dans Atmospheric Science Letters le 28/10/2020

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Résumé : The AMMA (African Monsoon Multidiscplinary Analysis) field programme aimed at documenting the West African Monsoon (WAM) climate system, in all its geophysical components. It also includes an important socioeconomic component. Encompassing a wide range of spatial and time scales, AMMA is one of the most ambitious such programmes ever set up. While the key accomplishments of AMMA are summarised in this paper, a few lessons of broad interest are also drawn both as a tribute to the extraordinary efforts made by a community of several hundreds of people and as possible guidelines for ensuring a long lasting future to integrated climate and environmental studies in West Africa.

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Fichiers liés : lebel et al 2011 AMMA.pdf

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