Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Guillaume Jean-Paul Claude BecqStéphane BonnetLorella MinottiMichel AntonakiosRégis GuillemaudPhilippe Kahane
• Organismes : GIPSA-Services INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information INSERM U836, équipe 9, Dynamique des réseaux synchrones épileptiques
• Publié dans Computers in Biology and Medicine le 30/10/2020

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Résumé : In order to characterize objectively the succession of movements observed during motor seizures, inertial and magnetic sensors were placed on epileptic patients. Video recordings synchronized with motion recordings were analyzed visually during seizures and divided, for each limb, into events corresponding to different classes of motor manifestations. For each classified event, features were extracted and a subset selection was automated using artificial neural networks. The best artificial neural network was simulated on whole recordings to generate a stereotypic evolution of motor manifestations that we called motorograms. It is shown that motorograms can point out seizure movements and emphasize epileptic patterns.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Jean-Philippe KarrLaurent HilicoVladimir Korobov
• Organismes : Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Bogoliubov Laboratory of Theoretical Physics [Dubna]
• Publié dans Canadian Journal of Physics le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Valérie JournotJean-Pierre PignonClaude GaultierVéronique DauratAnnie Bouxin-MétroBruno GiraudeauPierre-Marie PreuxJean-Marc TréluyerSylvie ChevretValérie PlättnerClaire ThalamasStéphanie ClisantPhilippe H. RavaudGeneviève Chêne
• Organismes : Epidémiologie et Biostatistique [Bordeaux] Service de biostatistique et d'épidémiologie Centre d’Investigation Clinique [Tours] CIC 1415 CIC-0901 Centre Hospitalier Lyon Sud [CHU - HCL] CIC - Biotherapie - Toulouse Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Epidémiologie et Biostatistique [Bordeaux]
• Publié dans Contemporary Clinical Trials le 31/10/2020

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Résumé : CONTEXT: Good Clinical Practice regulates monitoring activities in clinical research. Due to question and design diversity, and limited resources, on-site monitoring is often less intensive in the academic context, and variable. Standardization is needed, and relies on definition and validation of tools accounting for risk. OBJECTIVE: To define, and validate tools, to implement a risk-based monitoring strategy for academic clinical research. METHODS: Working groups of experienced professionals searched the literature, and built a consensus risk-assessment scale (RAS), and a risk-adapted monitoring plan (RAMP). We allocated 200 protocols to 49 assessors. We assessed the RAS relevance vs. a visual analogue scale (VAS), and its reproducibility through Kraemer's kappa, and intraclass correlation coefficient (ICC) from a random proportional odds model. We identified sources of disagreement through a logistic regression. We described assessors' difficulties during assessment. We applied the RAMP to 10 protocols per risk level, and rated its feasibility (0 = easy to 4 = impossible). RESULTS: RAS and RAMP were defined in 4 levels. RAS relevance was good: RAS-risk levels were evenly distributed on VAS-risk (0.6, 2.6, 5.6, and 7.9). Reproducibility was moderate to good: kappa=0.48, ICC=0.70. Major disagreements (36%) arose from decision-makers, rather than hands-on managers. Most difficulties occurred in ill-written protocols (17%). RAMP was easily feasible for most protocols (mean score: 0.2 to 0.9). We proposed a standard synopsis for evaluation purpose. CONCLUSION: We defined, and validated risk-based tools. This risk-adapted strategy will be compared to an intensive one in a randomized trial, Optimon, to define a standard of practice for academic clinical research.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Youssef HarrakMalika MakhloufStéphane AzzaroEmily MainettiJuan Manuel Lopez RomeroKevin CariouVincent GandonJean-Philippe GoddardMax MalacriaLouis Fensterbank
• Organismes : Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire Institut Parisien de Chimie Moléculaire
• Publié dans Journal of Organometallic Chemistry le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Ludovic GilletSébastien RogerPhilippe BougnouxJean-Yves Le GuennecPierre Besson
• Organismes : Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Niche, Nutrition, Cancer et métabolisme oxydatif Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Niche, Nutrition, Cancer et métabolisme oxydatif
• Publié dans Biochimie le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Laurence FleuryJean-Luc BoichardGuillaume BrissebratSophie ClochéLaurence EymardLaurence MastrorilloOumarou MoulayeKarim RamageNicole AsencioJean CoppeauxMarie-Pierre DevicFlorence FavotKarine GinouxJean-Philippe LaforeJan PolcherJean-Luc RedelspergerOdile RoussotMichel Tytéca
• Organismes : Centre national de recherches météorologiques Services communs OMP Services communs OMP Services communs OMP Institut Pierre-Simon-Laplace Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Services communs OMP Centre Régional AGRHYMET Institut Pierre-Simon-Laplace Centre national de recherches météorologiques Centre national de recherches météorologiques Centre national de recherches météorologiques Centre national de recherches météorologiques Institut Pierre-Simon-Laplace Centre national de recherches météorologiques Laboratoire de Météorologie Dynamique (UMR 8539) Centre national de recherches météorologiques Centre national de recherches météorologiques Centre national de recherches météorologiques
• Publié dans Atmospheric Science Letters le 28/10/2020

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Résumé : In the framework of the African Monsoon Multidisciplinary Analyses (AMMA) programme, several tools have been developed in order to facilitate and speed up data and information exchange between researchers from different disciplines. The AMMA information system includes a multidisciplinary user-friendly distributed data management and distribution system, a reports and quick looks archive associated with a display website and scientific papers exchange systems. All the applications have been developed by several French institutions and fully duplicated in Niamey, Niger.

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Fichiers liés : 10.1002_asl.303.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Marie-Pierre ChauzatAnne-Claire MartelNicolas CougoulePhilippe PortaJulie LachaizeSarah ZegganeMichel AubertPatrice CarpentierJean-Paul Faucon
• Organismes : Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Laboratoire de Sophia Antipolis Direction de l'évaluation des produits réglementés Laboratoire de Sophia Antipolis
• Publié dans Environmental Toxicology and Chemistry le 22/10/2020

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Résumé : The frequency of occurrence and relative concentration of 44 pesticides in apicultural (Apis mellifera) matrices collected from five French locations (24 apiaries) were assessed from 2002 to 2005. The number and nature of the pesticides investigated varied with the matrices examined-living honeybees, pollen loads, honey, and beeswax. Pollen loads and beeswax had the highest frequency of pesticide occurrence among the apiary matrices examined in the present study, whereas honey samples had the lowest. The imidacloprid group and the fipronil group were detected in sufficient amounts in all matrices to allow statistical comparisons. Some seasonal variation was shown when residues were identified in pollen loads. Given the results (highest frequency of presence) and practical aspects (easy to collect; matrix with no turnover, unlike with bees that are naturally renewed), pollen loads were the best matrix for assessing the presence of pesticide residues in the environment in our given conditions.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Noémie LigotPierre KrystkowiakClémence SimoninSerge GoldmanPhilippe PeigneuxJohn van NaemenMichel MonclusSimon Frédéric LacroixDavid DevosKathy DujardinChristine DelmaireEric BardinetArnaud DelvalMarie DelliauxLuc DefebvreJerome YelnikSerge BlondAlain DestéeXavier de Tiège
• Organismes : Service de neurologie [Amiens] Noyaux gris centraux Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis Neuropsychology and Functional Neuroimaging Research Unit - UR2NF Department of Neurology et Pathologie du Mouvement Département de neurologie [Lille] Services de neuroradiologie [Lille] Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] CIC AP-HP (pitie-Salpetriere)/inserm Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Département de neurologie [Lille]
• Publié dans Journal of Cerebral Blood Flow and Metabolism le 01/11/2020

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Résumé : Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : Anne-Christine MerveilleErica DavisAnita Becker-HeckMarie LegendreIsrael AmiravGéraldine BatailleJohn BelmontNicole BeydonFrédéric BillenAnnick ClémentCécile ClercxAndré CosteRachelle CrosbieJacques de BlicStephane DeleuzePhilippe DuquesnoyDenise EscalierEstelle EscudierManfred FliegaufJudith HorvathKent HillMark JorissenJocelyne JustAndreas KispertMark LathropNiki Tomas LogesJune MarthinYukihide MomozawaGuy MontantinKim NielsenHeike OlbrichJean-François PaponIsabelle RayetGilles RogerMiriam SchmidtsHenrique TenreiroJeffrey TowbinDiana ZelenikaHanswalter ZentgrafMichel GeorgesAnne-Sophie LequarréNicholas KatsanisHeymut OmranSerge Amselem
• Organismes : GIGA Institute [Université de Liège] Duke University Medical Center University Hospital Freiburg Albert-Ludwigs-Universität Freiburg = University of Freiburg University Hospital Münster - Universitaetsklinikum Muenster [Germany] CHU Trousseau [APHP] Physiopathologie des maladies génétiques d'expression pédiatrique Technion - Israel Institute of Technology [Haifa] GIGA Institute [Université de Liège] Baylor College of Medicine CHU Trousseau [APHP] Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich CHU Trousseau [APHP] Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Service d'ORL [Créteil] University of California [Los Angeles] Service de Pneumologie Allergologie [CHU Necker] Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] University Hospital Freiburg University Hospital Freiburg University of California [Los Angeles] Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain CHU Trousseau [APHP] Medizinische Hochschule Hannover = Hannover Medical School Genoscope - Centre national de séquençage [Evry] University Hospital Freiburg University Hospital Münster - Universitaetsklinikum Muenster [Germany] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] GIGA Institute [Université de Liège] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Copenhagen University Hospital [Denmark] = Københavns Universitetshospital [Danmark] University Hospital Freiburg Physiopathologie des maladies génétiques d'expression pédiatrique Physiopathologie des maladies génétiques d'expression pédiatrique Service d'ORL [Créteil] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] CHU Trousseau [APHP] University Hospital Freiburg Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Medizinische Hochschule Hannover = Hannover Medical School Genoscope - Centre national de séquençage [Evry] German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] GIGA Institute [Université de Liège] GIGA Institute [Université de Liège] Duke University Medical Center University Hospital Freiburg University Hospital Münster - Universitaetsklinikum Muenster [Germany] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans Nature Genetics le 29/10/2020

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Résumé : Primary ciliary dyskinesia (PCD) is an inherited disorder characterized by recurrent infections of the upper and lower respiratory tract, reduced fertility in males and situs inversus in about 50% of affected individuals (Kartagener syndrome). It is caused by motility defects in the respiratory cilia that are responsible for airway clearance, the flagella that propel sperm cells and the nodal monocilia that determine left-right asymmetry. Recessive mutations that cause PCD have been identified in genes encoding components of the outer dynein arms, radial spokes and cytoplasmic pre-assembly factors of axonemal dyneins, but these mutations account for only about 50% of cases of PCD. We exploited the unique properties of dog populations to positionally clone a new PCD gene, CCDC39. We found that loss-of-function mutations in the human ortholog underlie a substantial fraction of PCD cases with axonemal disorganization and abnormal ciliary beating. Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2011
• Auteurs : N'Goran Pamela YobouePhilippe MeniniAndré MaisonnatMyrtil L KahnKatia FajerwergBruno ChaudretPierre Fau
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination
• Publié dans MRS Online Proceedings Library le 03/03/2013

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Résumé : Air quality control in confined places (automotive cabin, transportation and offices or working places) is getting more and more pregnant in the actual pollution levels we are facing in our industrial environment. Despite the intense research work in the field of new silicon sensors and sensitive elements, the need for a high accuracy and low cost metal oxide gas sensors remains a challenge. This is due to the generally admitted drawbacks of this kind of silicon device: the resistance drift of the polysilicon heating element, the harsh mechanical stress of the membrane applied to the sensitive layer and the progressive deactivation of the thin oxide sensitive layer which lead to a decrease of sensor performance upon time. We have developed a very new generation of metal oxide gas sensor, based on the combination of optimized micromachined silicon substrates and highly sensitive nanosized metal oxides derived from organometallic synthesis means [1, 2]. For the first time, an integrated approach for a general sensor design has been employed [3, 4]. This new sensor design has been built in accordance with the upstream constraints coming from the deposition method required by the liquid nature of the sensitive material. A key parameter for an improved response of the sensor is the highly porous nature of the sensitive layer and the number of electrical contact between oxide grains. The more the number of possible current pathway during sensor operation and the less the risk of sensitivity decreases due to deactivation of grain boundaries. As a matter of fact, nanopowders offer the best ratio of grains and grain boundaries for a giving volume of sensitive layer. The presented results show the thermomechanical behavior of the silicon substrate, the electrical and thermal stability of the platinum based heater element, and the very low and controlled membrane deformation when operated. Round membrane shape and contact electrodes are build in respect with the drop deposition technique employed for the sensitive layer. This robust silicon design has been successfully employed with various metal oxide nanoparticles synthesized by organometallic means (SnO2, ZnO) and deposited by a generic ink jet method. High quality and micron thick layers can be obtained with a very low defect level (no cracks, no délamination) and gas sensitivity (under CO, C3H8 and NOx) and air stability are presented in comparison with classical thin films sensitive layers.

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Fichiers liés : proceeding Sensor v4.pdf

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