Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/11/2010
• Auteurs : Kenny R. Philippe AugusteHind MahéAbdel Karim FerchichiHong Wu LiJean-Pierre Vilcot
• Organismes : Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Fonctions Optiques pour les Technologies de l'informatiON Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Physique - IEMN Institut de Recherche en Energie Electrique de Nantes Atlantique EA4642 Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520

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Résumé : During the last decades, the research for the development of optical devices based on polymers is very extensive. Those organic materials make possible low manufacturing cost and high performance microwave photonic devices, such as optical modulators, with very large bandwidth and low drive voltage at 1310 nm and 1550 nm. To generate and maximize the electro-optic effect in those materials, it is necessary to orient all the chromophore dipoles in the same direction. In this paper, wire-to-plane configuration for corona poling and in-situ second harmonic generation detection techniques are used respectively to induce and to detect the alignment of the chromophores in a guest-host system (APC-CPO1). We report on experimental results obtained for various sample structures under same poling conditions. The sample structure affects the intensity of the corona current and its influence on poling efficiency has been studied through in-situ measurement of SHG (Second Harmonic Generation).

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Fichiers liés : TELFOR2010_06_09.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/11/2010
• Auteurs : Kenny Robert Philippe AugusteJean-François LegierErick PalecznyMathieu HalbwaxHind MahéLénaïck FontanieuJean-Pierre Vilcot
• Organismes : Institut d'Électronique et des Technologies du numéRique Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Fonctions Optiques pour les Technologies de l'informatiON Fonctions Optiques pour les Technologies de l'informatiON Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520

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Résumé : We report here a technique that we used to determine the complex permittivity of film structured polymer materials in the microwave frequency range. The goal is to obtain the data that are requested to design the microwave electrodes of Mach-Zehnder type optical modulators. As an example, the technique is applied to two materials that can be used in the fabrication of a high-speed optical polymer based modulator.

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Fichiers liés : TELFOR2010_06_08.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/11/2010
• Auteurs : Benoît MarinJean-Claude DesportPatrick KajeuPierre JésusBlerta NicolaudMarie PenotyPierre-Marie PreuxPhilippe Couratier
• Organismes : Neuroépidémiologie Tropicale et Comparée Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale et Comparée Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Service de Neurologie [CHU Limoges] Service de Neurologie [CHU Limoges] Institut de neurologie tropicale Neuroépidémiologie Tropicale et Comparée
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Objectives: The aims were to analyze changes in nutritional parameters from diagnosis of ALS to death and to assess their relationships with survival at the time of diagnosis and during follow-up. Methods: Ninety-two ALS patients were included and clinically assessed every three months (ALS FRS, MMT, forced vital capacity, weight, BMI, percent weight loss). Bioimpedance was performed to evaluate body composition (fat-free mass, fat mass and hydration status) and phase angle. Survival analyses were performed from diagnosis to death or censoring date using a Cox model. Results: The evolution of nutritional parameters in ALS patients was marked by significant decreases in weight, BMI, fat-free mass and phase angle, and increased fat mass. We identified an adjusted 30% increased risk of death for a 5% decrease from usual weight at time of diagnosis (Relative Risk (RR): 1.30 95%CI 1.08-1.56). During follow-up, we identified adjusted 34% (95%CI 18-51) and 24% (95%CI 13-36) increased risks of death associated with each 5% decrease in usual weight and each unit decrease in usual BMI, respectively (p<0.0001). Malnutrition during the course was related to shorter survival (p=0.01), and fat mass level was associated with a better outcome (RR 0.90 for each 2.5-kg fat mass increment). Conclusions: Nutritional parameters of ALS patients worsened during evolution of the disease and worse nutritional status (at time of diagnosis or during the course) was associated with higher mortality. This study offers some justification for studying the use of therapeutic nutritional intervention to modify the survival of ALS patients.

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Fichiers liés : PEER_stage2_10.1136%2Fjnnp.2010.211474.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/11/2010
• Auteurs : David GorisseFrédéric PreciosoPhilippe-Henri GosselinLionel GranjonDenis PellerinMichèle RombautHervé BredinLionel KoenigRemi VieuxBoris MansencalJenny Benois-PineauHugo BoujutClaire MorandHervé JégouStéphane AyacheBahjat SafadiYubing TongFranck ThollardGeorges QuénotMatthieu CordA BenoitPatrick Lambert
• Organismes : Equipes Traitement de l'Information et Systèmes Machine Learning and Information Retrieval Equipes Traitement de l'Information et Systèmes Equipes Traitement de l'Information et Systèmes GIPSA-Services GIPSA - Architecture, Géométrie, Perception, Images, Gestes GIPSA - Architecture, Géométrie, Perception, Images, Gestes Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Centre National de la Recherche Scientifique Équipe Structuration, Analyse et MOdélisation de documents Vidéo et Audio Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Laboratoire Bordelais de Recherche en Informatique Multimedia content-based indexing Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Laboratoire d'Informatique de Grenoble Machine Learning and Information Retrieval Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance

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Résumé : The IRIM group is a consortium of French teams working on Multimedia Indexing and Retrieval. This paper describes our participation to the TRECVID 2010 semantic indexing and instance search tasks. For the semantic indexing task, we evaluated a number of different descriptors and tried different fusion strategies, in particular hierarchical fusion. The best IRIM run has a Mean Inferred Average Precision of 0.0442, which is above the task median performance. We found that fusion of the classification scores from different classifier types improves the performance and that even with a quite low individual performance, audio descriptors can help. For the instance search task, we used only one of the example images in our queries. The rank is nearly in the middle of the list of participants. The experiment showed that HSV features outperform the concatenation of HSV and Edge histograms or the Wavelet features.

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Fichiers liés : IRIMatTRECVID2010.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/11/2010
• Auteurs : Laurie WatterlotTatiana RochatHarry SokolClaire CherbuyIsmael BouloufaFrançois LefèvreJean-Jacques GratadouxEdith Honvo-HuetoStefan ChilmonczykSébastien BlugeonGérard CorthierPhilippe LangellaLuis G Bermúdez-Humarán
• Organismes : Unité de recherche d'Écologie et Physiologie du Système Digestif CHU Saint-Antoine [AP-HP] Université Pierre et Marie Curie - Paris 6 Unité de recherche Virologie et Immunologie Moléculaires
• Publié dans International Journal of Food Microbiology le 30/10/2020

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Résumé : Human immune cells release large amounts of reactive oxygen species (ROS) such as superoxide radical and hydrogen peroxide via respiratory burst. In inflammatory bowel diseases, a sustained and abnormal activation of the immune response results in oxidative stress of the digestive tract and in a loss of intestinal homeostasis. We previously reported that heterologous production of the Lactobacillus plantarum manganese catalase (MnKat) enhances the survival of Lb. casei BL23 when exposed to oxidative stress. Anti-inflammatory effects were observed after Lb. casei BL23 oral administrations in moderate murine dextran sodium sulfate (DSS)-induced colitis, without added effects of the MnKat production. Here, we evaluated the protective effects obtained by an improved antioxidative strategy. The Lactococcus lactis sodA gene was expressed in Lb. casei BL23 which acquired an efficient manganese superoxide dismutase (MnSOD) activity. The effects of Lb. casei MnSOD alone or in combination with Lb. casei MnKat were compared first in eukaryotic cell PMA-induced oxidative stress model and then in severe murine DSS-induced colitis. Based on ROS production assays as well as colonic histological scores, a significant reduction of both oxidative stress and inflammation was observed with Lb. casei MnSOD either alone or in combination with Lb. casei MnKat. No added effect of the presence of Lb. casei MnKat was observed. These results suggest that Lb. casei BL23 MnSOD could have anti-inflammatory effects on gut inflammation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 15/11/2010
• Auteurs : Pierre-Yohan MichaudSabine MeunierPhilippe HerzogMathieu LavandierGérard Drouët d'Aubigny
• Organismes : Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Laboratoire de Mécanique et d'Acoustique [Marseille] Département génie civil et batiment (ENTPE) Méthodologie Statistique et Sciences Sociales

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• Type de publi. : Article dans une revue
• Date de publi. : 10/11/2010
• Auteurs : Boyan Ivanov DimitrovIrina BalikovaThomy de RavelHilde van EschMaryse de SmedtEmiel BatenJoris Robert VermeeschIrena BradinovaEmil SimeonovKoenraad DevriendtJean-Pierre FrynsPhilippe Debeer
• Organismes : Centre for Human Genetics Centre for Human Genetics Centre for Human Genetics Centre for Human Genetics AZ Sint-Augustinus, 2610 Wilrijk Sint Lucas Hospital, 8310 Bruges Centre for Human Genetics University Hospital Aleksandrovska, Department of Paediatrics, Medical University Sofia, 1431 Sofia University Hospital Aleksandrovska, Department of Paediatrics, Medical University Sofia, 1431 Sofia Centre for Human Genetics Centre for Human Genetics Catholic University of Leuven = Katholieke Universiteit Leuven
• Publié dans Journal of Medical Genetics le 26/10/2020

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Résumé : Introduction: The clinical phenotype of the chromosome 2q31 deletion syndrome consists of limb anomalies ranging from monodactylous ectrodactyly, brachydactyly and syndactyly to camptodactyly. Additional internal organ anomalies, e.g. heart defects, ocular anomalies may be present. Hemizygosity for HOXD13 and EVX2 genes was thought to cause the observed skeletal defects. Recently, based on the phenotype of patients with overlapping 2q31 interstitial deletions, a new SHFM5 locus was proposed- proximal to the HOXD cluster, between EVX2 and marker D2S294. DLX1 and DLX2 haploinsufficiency was suggested as the most plausible explanation for the observed SHFM-like limb anomalies in these cases. Methods and Results: Five unique, interstitial 2q31 deletion patients were selected to further characterize the 2q31 region and to establish a genotype/phenotype correlation map. The size of the deletions was delineated with a chromosome 2 specific tiling path BAC array. The clinical and molecular data for this group of patients were compared to others in the literature. A common locus for the observed skeletal anomalies, including the HOXD genes and surrounding regulatory sequences, was delineated. These results correlate with recently published studies in animal models. In addition, a critical region for the facial gestalt of the 2q31.1 microdeletion syndrome was delineated. Conclusions: Our results reinforce the hypothesis that the variable skeletal phenotype in 2q31 deletion patients is a result of hemizygosity for the HOXD genes and that the 2q31.1 microdeletion syndrome is a well defined and clinically recognizable phenotype.

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Fichiers liés : PEER_stage2_10.1136%2Fjmg.2010.079491.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/11/2010
• Auteurs : Gabriel VasileJean-Philippe OvarlezFrédéric PascalMichel GayEric Guy d'UrsoDider Boldo
• Organismes : GIPSA - Signal Images Physique ONERA - The French Aerospace Lab [Toulouse] Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) GIPSA-Services EDF – Électricité de France EDF R&D

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Résumé : This paper presents a new estimation scheme for optimally deriving clutter parameters with high resolution repeat-pass SAR interferometry. The heterogeneous clutter in InSAR data is described by the Spherically Invariant Random Vectors model. Three parameters are introduced for the high resolution InSAR data clutter: the span, the normalized texture and the speckle normalized covariance matrix. The asymptotic distribution of the novel span estimator is investigated.

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Fichiers liés : Stable Scatterers Detection.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 02/11/2010
• Auteurs : Sébastien LasvauxBruno PeuportierJacques ChevalierPhilippe Garat
• Organismes : Centre Scientifique et Technique du Bâtiment CEP/Paris Centre Scientifique et Technique du Bâtiment Statistique Fonctionnelle & Sondages

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Résumé : The Life Cycle Assessment (LCA) methodology is known to be a powerful tool for the analysis of the main flows of energy, matter and resulting emitted pollutants within a given system boundaries of any products or processes. Yet, to date, it is often seen as a complex task to carry out especially because of the huge amount of data - at the inventory step - to deal with. In this paper, we investigate some statistical methods to produce simplified characterization models (SCM) for the usual life cycle impact assessment (LCIA) indicators. The methodology aims at detecting the most significant and robust LCI flows that predominantly contribute in the calculation of each LCIA indicator. The problem cannot be solved using classical stepwise regression techniques due to the type of data. We explored a French LCI database for the building sector gathering 108 generic materials data and 376 EPDs data based on a same LCI model and expressed as kg or m² of functional unit [1]. First, different indicators are calculated for each material and product in the database using full additive models and second, the level of significance of each LCI flow is assessed using its statistical p.value and transforming it into a rank score. This second step is repeated 10000 times on resampled subsets of the database. This technique proves to be quite efficient to detect the most robust contributors for a given LCIA indicator. An application for the ADP indicator limited to the non energetic resources (ADP-CRNE) shows the feasibility of deriving a simplified characterization model (SCM) with the help of only 8 resources namely the boron, the cadmium, the chromium, the copper, the tin, the molybdenum, the lead and the zinc. We then attempt to validate the SCM on two building case studies in order to assess whether the weighting of the functional units (kg, m²) of materials and products results in deviation of the SCM. It was finally found that the relative deviation between the detailed ADP-CRNE and the simplified one is only 1,86% for the masonry constructive system (62.37 vs. 61.21 kg eq-Sb) and 1,47% for the wooden constructive system (2.77 vs. 2.68 kg eq-Sb).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2010
• Auteurs : Arnaud PrébéPierre AlcouffePhilippe CassagnauJean-François Gérard
• Organismes : Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Macromoléculaires Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux
• Publié dans Materials Chemistry and Physics le 28/10/2020

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Résumé : Chemiorheology, i.e. rheological changes during the polymerization, of a biosourced monomer, i.e. L-Lactide, containing fumed silica have been studied. For that purpose, the reaction was proceeded in situ between the plates of a dynamic rheometer. The polymerization kinetics was followed from the variation of the complex shear modulus versus reaction time. Moreover, at temperatures lower than the crystallization temperature, it was possible to follow the crystallization process while the polymerization takes place. Adding fumed silica particles into the monomer leads to the formation of a physical (percolated) network from particle-particle interactions, i.e. silica, in the L-Lactide probably hydrophilic interactions. The gel-like structure was kept while the polymerization as long as the strain remains low indicating that the silica particle network remains weak Furthermore, the mechanism of the break down of the gel structure under large deformation as well as the recovery was discussed. It seems that the non-linearity effect of the nanocomposites stems in the silica inter-particle interactions. It was found that silica particles do not have any effect on the temperature of crystallization - molar mass relation but could act as nucleating agent. In situ polymerization of L-Lactide in the presence of 5 wt.% of modified fumed silica was carried out in a reactor. It was found that fumed hydrophilic silica leaded to a microcomposite with highly dense agglomerates in the polymer matrix whereas with a less hydrophilic silica it was possible to decrease the size of the agglomerates increasing the dispersion. The finest dispersion state was achieved with the "initiating" functionalized silica leading to a "grafting from" polymerization of the L-Lactide. Such functionalized silica leads to a nanoscale dispersion in a one-step bulk polymerization with only a few small agglomerates. (C) 2010 Elsevier B.V. All rights reserved.

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