Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 28/10/2010
• Auteurs : Annie Prado-JeanPhilippe CouratierLaurent Amounou Bénissan-TeviPhilippe NubukpoMichel Druet-CabanacJean-Pierre Clément
• Organismes : Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Neuroépidémiologie Tropicale et Comparée Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Hôpital Psychiatrique La Valette Neuroépidémiologie Tropicale et Comparée Unité Fonctionnelle Registre Général des Cancers du Limousin Service de Santé au Travail [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges]
• Publié dans International Journal of Geriatric Psychiatry le 25/10/2020

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Résumé : Depression is often overlooked in elderly nursing home residents because symptoms may be masked or dismissed as an inevitable consequence of ageing. Current tools for the detection of depression in institutionalised older people are not always specific.AIMS: To construct and verify an instrument with which to detect depression in elderly nursing home residents (NH-SDI). METHOD: Firstly for the construction, 328 elderly people were selected at random from the residents of 17 nursing homes in France, and examined by a single investigator. The examination included a psychiatric assessment, an evaluation of cognitive function using the MMSE, an evaluation of depressive state using four different instruments (mini-GDS, Goldberg, DMAS, CSDD), and assessment of any changes in behaviour in those suffering from dementia, using the NPI. A second stage was to confirm NH-SDI in 99 institutionalised subjects. RESULTS: Following the selection of items, we created a scale of 16 dichotomous items (NH-SDI). The internal consistency was satisfactory (α Cronbach = 0.85), as was its reliability with a sensitivity of 85.1% and a specificity of 86.5% for a cut-off score above 5. CONCLUSIONS: The NH-SDI appears to be a useful instrument for the detection of depression in nursing homes and can easily be applied by healthcare staff as part of routine procedures. Copyright © 2010 John Wiley & Sons, Ltd.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/10/2010
• Auteurs : Philippe HalfonSophie PérusatMarc BourlièreJean-Pierre BronowickiPascale TrimouletYves BehnamouVincent LeroyPatrick MarcellinJuliette FoucherGuillaume PénarandaGeneviève ChênePatrice Couzigou
• Organismes : Service de virologie et d'immunologie biologique Service d'hépatologie Service de virologie et d'immunologie biologique Laboratoire Alphabio Service de virologie et d'immunologie biologique
• Publié dans Journal of Medical Virology le 25/10/2020

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Résumé : Statement of the problem A lack of antiviral response in chronic hepatitis C patients treated by pegylated (PEG)-interferon (IFN) α-2a + ribavirin (RIBA) might be explained by neutralizing antibodies to IFN α-2a. The aim was to assess neutralizing antibodies to IFN α-2a and IFN levels in non-responder patients who were re-treated by PEG IFN α-2a and RIBA for 12 weeks. Methods of study Non-responders to a first-line treatment were included to receive PEG IFN α-2a + RIBA for 48 weeks. HCV RNA was measured at week 12 using TaqMan Roche. IFN levels and neutralizing antibodies to IFN α-2a were retrospectively measured on stored sera at baseline, week 4, and 12, using a quantitative sandwich ELISA for neutralizing antibodies to IFN α-2a. Results Twenty-three patients were non-responders and 19 patients were responders at week 12 of the initial phase of second-line treatment. Non-responders and responders did not statistically differ. Median IFN α-2a levels (pg/ml) at weeks 0, 4, and 12 (interquartile range) did not differ between the 19 responders to initial phase of second line treatment and the 23 non-responders :< 3.3 (<3.3- 371.4), 1457.3 (106.8- 3284.8), and 1652 (90.8- 5000); 84.5 (3.3- 277.4), 1407.4 (120.2- 2443.4), and 1620.1 (120.2- 2287.1) respectively. Conclusions Among non-selected consecutive non-responders patients, re-treatment with PEG IFN α-2a + RIBA is associated with virological response regardless of the presence of antibody-mediated resistance to conventional IFN treatment.

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Fichiers liés : PEER_stage2_10.1002%2Fjmv.21909.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/10/2010
• Auteurs : Stéphane CollinClement ColinChristophe SauvanInès RevolFabrice PardoNicolas Péré-LaperneP. GhenucheNathalie BardouPhilippe LalanneJean-Luc Pelouard
• Organismes : Laboratoire de photonique et de nanostructures Laboratoire de photonique et de nanostructures Laboratoire Charles Fabry de l'Institut d'Optique / Naphel Laboratoire de photonique et de nanostructures Laboratoire de photonique et de nanostructures Laboratoire de photonique et de nanostructures Laboratoire Pierre Aigrain Laboratoire de photonique et de nanostructures Laboratoire de photonique et de nanostructures Laboratoire Charles Fabry de l'Institut d'Optique / Naphel Laboratoire de photonique et de nanostructures

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/10/2010
• Auteurs : Sidonie RévillonFabien ArnaudMarie RevelCharline Giguet-CovexJean-Philippe Jenny
• Organismes : Unité Géosciences Marines Environnements, Dynamiques et Territoires de Montagne Géoazur Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/10/2010
• Auteurs : N. KudryavtsevaW. BrandnerStefan HipplerThomas HenningCarolina BergforsFelix HormuthThibaut PaumardPierre KervellaJean-Philippe Berger
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA

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• Type de publi. : Article dans une revue
• Date de publi. : 22/10/2010
• Auteurs : Yves CherelCamille FontainePierre RichardJean-Philippe Labat
• Organismes : Centre d'Études Biologiques de Chizé Centre d'Études Biologiques de Chizé LIttoral ENvironnement et Sociétés Océanographie Biologique et Écologie du Plancton Marin
• Publié dans Limnology and Oceanography le 23/10/2020

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Résumé : We report the trophic structure of a myctophid assemblage by measuring the isotopic niches of 14 species living in Kerguelen waters, southern Indian Ocean. Most of the species show distinct isotopic niches that differ by at least one of the two niche axes (d13C habitat and d15N trophic position), indicating trophic partitioning within the assemblage. Strong niche segregation occurs within each of the three most common genera of myctophids (Electrona, Gymnoscopelus, and Protomyctophum), illustrating the different mechanisms (habitat and dietary segregation) that allow coexistence of closely related species. Calculated trophic levels (TLs) of myctophids ranged from 3.3 to 4.2, showing that they are secondary and tertiary consumers in the pelagic ecosystem. The positive relationship between TL and standard length of fish points out a structuring effect of size, with larger species (Gymnoscopelus spp.) occupying a higher trophic position than smaller species (Krefftichthys anderssoni and Protomyctophum spp.). Myctophids occupy an intermediate trophic position between macrozooplanktonic crustaceans and seabirds and marine mammals within the pelagic ecosystem. However, the TLs of large myctophids overlap those of crustacean-eating seabirds [e.g., Eudyptes spp. (crested penguins) and Pachyptila belcheri]. The isotopic niche of myctophids indicates that Aptenodytes patagonicus (king penguin) adults prey upon K. anderssoni when they feed for themselves, thus exemplifying the usefulness of isotopic datasets on potential prey of predators to depict trophic relationships.

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• Type de publi. : Article dans une revue
• Date de publi. : 20/10/2010
• Auteurs : Sébastien HantzFrançoise Garnier-GeoffroyMarie-Christine MazeronIsabelle GarriguePierre MervilleCatherine MengelleLionel RostaingFranck Saint-MarcouxMarie EssigJean-Philippe RerolleSébastien CotinRaphaële GermiSylvie PilletYvon LebranchuPascal TurlureSophie Alain
• Organismes : Biologie moléculaire et cellulaire des microorganismes Service de Bactériologie, Virologie, Hygiène [CHU Limoges] Service de Bactériologie, Virologie, Hygiène [CHU Limoges] Laboratoire de Bactériologie-Virologie Service de virologie et d'immunologie biologique Service de Néphrologie-transplantation-dialyse [Bordeaux] Laboratoire Virologie [CHU Toulouse] Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques [CHU Toulouse] Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges] Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Biologie moléculaire et cellulaire des microorganismes Laboratoire de Virologie Service de Virologie [CHU Saint-Etienne] Service de néphrologie et immunologie clinique [CHRU Tours] Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges] Biologie moléculaire et cellulaire des microorganismes Service de Bactériologie, Virologie, Hygiène [CHU Limoges]
• Publié dans Journal of Antimicrobial Chemotherapy le 31/10/2020

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Résumé : Objectives Cytomegalovirus (CMV) drug resistance is a therapeutic challenge in the transplant setting. No longitudinal cohort studies of CMV resistance in a real-life setting have been published in the valganciclovir era. We report findings for a French multicentre prospective cohort of 346 patients enrolled at initial diagnosis of CMV infection (clinical trial registered at clinicaltrials.gov: NCT01008540). Patients and methods Patients were monitored for detection of CMV infection for ≥2 years. Real-time detection of resistance by UL97 and UL54 gene sequencing and antiviral phenotyping was performed if viral replication persisted for >21 days of appropriate antiviral treatment. Plasma ganciclovir assays were performed when resistance was suspected. Results Resistance was suspected in 37 (10.7%) patients; 18/37 (5.2% of the cohort) had virological resistance, associated with poorer outcome. Most cases involved single UL97 mutations, but four cases of multidrug resistance were due to UL54 mutations. In solid organ transplant recipients, resistance occurred mainly during primary CMV infection (odds ratio 8.78), but also in two CMV-seropositive kidney recipients. Neither CMV prophylaxis nor antilymphocyte antibody administration was associated with virological resistance. Conclusions These data show the feasibility of surveying resistance. Virological resistance was frequent in patients failing antiviral therapy. More than 1/5 resistant isolates harboured UL54 mutations alone or combined with UL97 mutations, which conferred a high level of resistance and sometimes were responsible for cross-resistance, leading to therapeutic failure.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/10/2010
• Auteurs : P.J. DebouttierePierre FauKatia FajerwergMyrtil L KahnNicolas PinnaNicolas DufourPhilippe MeniniBruno Chaudret
• Organismes : Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination Équipe MICrosystèmes d'Analyse

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Résumé : Gas detection is of great interest for many different applications such as domestic and industrial security or air quality supervision. Today, the most common gas-sensing devices, produced at low cost and in vast quantity, are electrochemical and metal oxide semi-conductor devices. For years, our team has been involved in the research of original synthesis of SnO2 nanostructured materials by an organometallic approach. Monodispersed nanocomposites particles of Sn/SnOx have notably been synthesized by decomposition of an amine derivative precursor, [(Sn(NMe2)2]2. These nanoparticles have also proven an industrial application in the detection of automotive driven target gas (CO, NO2). Moreover, our team has developed expertise in synthesis of noble nanoparticles (Ru, Pt, Pd...) especially for application in catalysis. These nanoparticles are also of great interest for improvement of sensibility and selectivity in metal oxide doping. A full study and the manufacture of tin oxide gas sensors aimed towards an industrial selective detection has been launched. This study has focused on cabin air quality especially concerning odorous gases present in an automobile environment. A template with an interdigit structure has been optimized and manufactured at the LAAS. SnO2 nanomaterial synthesized by an organometallic non-aqueous approach and deposited on an SiO2 template by an inkjet technique has been studied. The doping in colloidal solution of noble metals (Ru, Pt) has been realized in various ways such as by colloidal mixing or by decomposition in situ on SnO2. Finally, gas tests have been performed on doped and undoped sensitive layers. We have focused special attention on acetaldehyde and ammoniac as reference odorous gases. The sensors developed have shown good sensibility to these two gases, yielding interesting perspectives on the selective gas detection of odorous gas in automobile cabins

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/10/2010
• Auteurs : Pierre-Jean DebouttièrePierre FauKatia FajerwergMyrtil L KahnBruno ChaudretNicola PinnaPhilippe MeniniNicolas DufourLaetitia Del FabbroMuriel Touaty
• Organismes : Laboratoire de chimie de coordination Laboratoire de chimie de coordination Équipe MICrosystèmes d'Analyse

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Résumé : Air quality control in closed spaces (e.g. automotive cabin, transportation and offices or working places) is getting more and more relevant due to the actual pollution levels present in our environment. In the past, our research group has successfully developed an advanced generation of metal oxide gas sensor, based on the combination of a micromachined silicon substrates and nanosized core shell Sn/SnOx composite derived from organometallic synthesis [1]. These sensors have been industrialized and implemented as air quality sensors in the automotive industry. A very new and improved generation of integrated gas sensors is presented here. It combines an improved silicon micromachined substrate and a fully oxidized nanosized tin dioxide material [2-4]. A key parameter for an improved response of the sensor is the highly porous nature of the sensitive layer that leads to a high number of electrical contacts between oxide grains. Indeed, the higher is the number of possible current pathways during sensor operation, the lower is the risk of sensitivity decreases due to deactivation of grain boundaries. As a matter of fact, for a given volume of sensitive layer, nanopowders offer the best ratio of grains and grain boundaries. The presented results demonstrate the high thermomechanical properties of the silicon substrate, the electrical and thermal stability of the platinum based heater element, and the very low membrane deformation during operation. High quality and micron thick layers can be obtained with a very low defect level (no cracks, no délamination). In addition, our team has developed a catalysis oriented approach for the improvement of the sensor response and selectivity: noble metal (Ru, Pt...) are added to the SnO2 matrix in order to reduce the response time and to increase the sensitivity of the sensors. Gas responses under CO, C3H8, NH3 and CH3CHO on undoped and doped layer are presented and discussed in view of applications in the selective gas detection of odorous gases in automobile cabins.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 18/10/2010
• Auteurs : Lisa PinFlorence AnsartPhilippe LoursJulien SniezewskiJustine FenechJean-Pierre BoninoYannick Le Maoult
• Organismes : Institut Clément Ader Centre interuniversitaire de recherche et d'ingénierie des matériaux Institut Clément Ader Institut Clément Ader Centre interuniversitaire de recherche et d'ingénierie des matériaux Institut Clément Ader

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