Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/09/2010
• Auteurs : Pierre-Yves LéoMarie-Christine Longe MonnoyerJean Philippe
• Organismes : Centre d'Études et de Recherche en Gestion d'Aix-Marseille UR Céres (Culture, Éthique, Religion Et Société) Centre d'Études et de Recherche en Gestion d'Aix-Marseille

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Résumé : Literature about Innovation, as an antecedent factor of internationalization is not abundant. If co-production means links between business service firms and their clients, it can also be an innovation source for business service firms Service innovation has mainly been studied as a resulting process in firm of R&D, or ongoing transformation in service offer: our objective is to build and assess a model of determinants to measure their relative impact on innovation. We presented our methodology, the state of art and the preliminary findings of two in depth case studies on international knowledge intensive business service that have based their development on innovation. Résumé Le rôle de l'innovation comme préalable ou facteur porteur de l'internationalisation des entreprises de services a jusqu'à présent été peu étudié. Via la co-production du service avec le client, la demande apparaît comme la source d'une évolution de l'offre qui peut ainsi être innovante. Nous cherchons à montrer que l'innovation peut être un déclencheur de l'exportation pour les services aux entreprises les plus intensifs en connaissances. Cette communication présente la méthodologie d'une recherche en cours et les fondements d'un modèle en construction s'appuyant sur une revue de littérature et deux entretiens approfondis auprès d'entreprises de ce secteur.

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Fichiers liés : Texte RESER 2010 version 3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2010
• Auteurs : Pajot F.P.A.R. AdeJ.-L. BeneyÉric BréelleD. BroszkiewiczPhilippe CamusC. CarabétianAndrea CatalanoA. ChardinM. CharraJ. CharraR. CizeronF. CouchotAlain CoulaisB.P. CrillK. DassasJ. DaubinP. de BernardisP. de MarcillacJ.-M. DelouisF.-X. DésertP. DuretP. EngC. EvesqueJ.-J. FourmondS. FrançoisM. GiardY. Giraud-HéraudL. GuglielmiG. GuyotJ. HaissinskiSophie Henrot-VersilléV. HervierW. HolmesW.C. JonesJ.-M. LamarreP. LamiA.E. LangeM. . LefebvreB. LericheClementine LeroyJ.F. Macias-PerezT. MaciaszekBruno MaffeiA. MahendranB. MansouxC. MartyS. MasiMarc-Antoine Miville-DeschenesL. MontierC. NicolasF. NovielloO. PerdereauF. PiacentiniM. PiatStéphane PlaszczynskiEtienne PointecouteauR. PonsN. PonthieuJ.-L. PugetD. RambaudC. RenaultJ.-C. RenaultC. RiouxI. RistorcelliC. RossetG. SaviniR. SudiwalaJ.-P. TorreM. TristramD. ValléeM. VenezianiD. YvonClaude Mercier
• Organismes : Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie AstroParticule et Cosmologie Cryogénie Institut d'astrophysique spatiale AstroParticule et Cosmologie Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Laboratoire de l'Accélérateur Linéaire Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Laboratoire d'Astrophysique de Grenoble Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Centre d'étude spatiale des rayonnements APC - Cosmologie AstroParticule et Cosmologie Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Laboratoire de l'Accélérateur Linéaire Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de Physique Subatomique et de Cosmologie Centre National d'Études Spatiales [Toulouse] Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire Centre d'étude spatiale des rayonnements Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Institut d'astrophysique spatiale Centre d'étude spatiale des rayonnements Laboratoire de Physique Subatomique et de Cosmologie Institut d'Astrophysique de Paris Institut d'astrophysique spatiale Centre d'étude spatiale des rayonnements Laboratoire de l'Accélérateur Linéaire Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie AstroParticule et Cosmologie Département de Physique des Particules (ex SPP) Institut d'astrophysique spatiale
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Fichiers liés : aa13203-09.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2010
• Auteurs : Vincent GajdosSandrine KatsahianNicole BeydonVéronique AbadieLoïc de PontualSophie LarrarRalph EpaudBertrand ChevallierSylvain BailleuxAlix Mollet-BoudjemlineJean BouyerSylvie ChevretPhilippe Labrune
• Organismes : Service de pédiatrie [Béclère] Centre de recherche en épidémiologie et santé des populations Service de biostatistiques et information médicale [Saint-Louis] Biostatistique et épidemiologie clinique Service de pneumologie [Debré] Service de pédiatrie générale [CHU Necker] Service de Pédiatrie [Jean Verdier] Service d'urgences pédiatrique Centre de Recherche Saint-Antoine Service de pédiatrie, urgences enfants [CHU Ambroise-Paré] Service de pédiatrie [Béclère] Service de pédiatrie [Béclère] Centre de recherche en épidémiologie et santé des populations Service de biostatistiques et information médicale [Saint-Louis] Biostatistique et épidemiologie clinique Service de pédiatrie [Béclère]
• Publié dans PLoS Medicine le 27/10/2020

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Résumé : BACKGROUND: Acute bronchiolitis treatment in children and infants is largely supportive, but chest physiotherapy is routinely performed in some countries. In France, national guidelines recommend a specific type of physiotherapy combining the increased exhalation technique (IET) and assisted cough (AC). Our objective was to evaluate the efficacy of chest physiotherapy (IET + AC) in previously healthy infants hospitalized for a first episode of acute bronchiolitis. METHODS AND FINDINGS: We conducted a multicenter, randomized, outcome assessor-blind and parent-blind trial in seven French pediatric departments. We recruited 496 infants hospitalized for first-episode acute bronchiolitis between October 2004 and January 2008. Patients were randomly allocated to receive from physiotherapists three times a day, either IET + AC (intervention group, n=246) or nasal suction (NS, control group, n=250). Only physiotherapists were aware of the allocation group of the infant. The primary outcome was time to recovery, defined as 8 hours without oxygen supplementation associated with minimal or no chest recession, and ingesting more than two-thirds of daily food requirements. Secondary outcomes were intensive care unit admissions, artificial ventilation, antibiotic treatment, description of side effects during procedures, and parental perception of comfort. Statistical analysis was performed on an intent-to-treat basis. Median time to recovery was 2.31 days, (95% confidence interval [CI] 1.97-2.73) for the control group and 2.02 days (95% CI 1.96-2.34) for the intervention group, indicating no significant effect of physiotherapy (hazard ratio [HR]=1.09, 95% CI 0.91-1.31, p=0.33). No treatment by age interaction was found (p=0.97). Frequency of vomiting and transient respiratory destabilization was higher in the IET + AC group during the procedure (relative risk [RR]=10.2, 95% CI 1.3-78.8, p=0.005 and RR=5.4, 95% CI 1.6-18.4, p=0.002, respectively). No difference between groups in bradycardia with or without desaturation (RR=1.0, 95% CI 0.2-5.0, p=1.00 and RR=3.6, 95% CI 0.7-16.9, p=0.10, respectively) was found during the procedure. Parents reported that the procedure was more arduous in the group treated with IET (mean difference=0.88, 95% CI 0.33-1.44, p=0.002), whereas there was no difference regarding the assessment of the child's comfort between both groups (mean difference=-0.07, 95% CI -0.53 to 0.38, p=0.40). No evidence of differences between groups in intensive care admission (RR=0.7, 95% CI 0.3-1.8, p=0.62), ventilatory support (RR=2.5, 95% CI 0.5-13.0, p=0.29), and antibiotic treatment (RR=1.0, 95% CI 0.7-1.3, p=1.00) was observed. CONCLUSIONS: IET + AC had no significant effect on time to recovery in this group of hospitalized infants with bronchiolitis. Additional studies are required to explore the effect of chest physiotherapy on ambulatory populations and for infants without a history of atopy. TRIAL REGISTRATION: ClinicalTrials.gov NCT00125450.

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Fichiers liés : journal.pmed.1000345.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2010
• Auteurs : J.-M. LamarreJ.-L. PugetP.A.R. AdeFrançois R. BouchetG. GuyotA. E. LangePajot F.A. ArondelKarim BenabedJ.-L. BeneyAlain BenoitJ.-Ph. BernardR. BhatiaY. BlancJ. J. BockÉric BréelleT. W. BradshawPhilippe CamusAndrea CatalanoJ. CharraM. CharraS. E. ChurchF. CouchotAlain CoulaisB. P. CrillM. R. CrookK. DassasP. de BernardisJ. DelabrouilleP. de MarcillacJ.-M. DelouisF.-X. DésertC. DumesnilX. DupacG. EfstathiouP. EngC. EvesqueJ.-J. FourmondK. GangaM. GiardR. GispertL. GuglielmiJ. HaissinskiSophie Henrot-VersilléE. HivonW. A. HolmesW. C. JonesT. C. KochH. LagardèreP. LamiJ. LandéB. LericheClementine LeroyY. LongvalJ.F. Macias-PerezT. MaciaszekBruno MaffeiB. MansouxC. MartyS. MasiMarc-Antoine Miville-DeschenesA. MonetiL. MontierJ. A. MurphyJ. NarbonneM. NexonC. G. PaineJ. PahnO. PerdereauF. PiacentiniM. PiatStéphane PlaszczynskiEtienne PointecouteauR. PonsN. PonthieuSimon PrunetD. RambaudG. RecouvreurC. RenaultI. RistorcelliC. RossetD. SantosG. SaviniG. SerraP. StassiR.V. SudiwalaJ.F. SygnetJ. A. TauberJ.-P. TorreM. TristramL. VibertA. WoodcraftV. YurchenkoD. YvonClaude Mercier
• Organismes : Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Laboratoire de l'Accélérateur Linéaire Hélium : du fondamental aux applications Centre d'étude spatiale des rayonnements AstroParticule et Cosmologie Cryogénie AstroParticule et Cosmologie Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Institut d'astrophysique spatiale APC - Gravitation Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Laboratoire d'Astrophysique de Grenoble Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale APC - Cosmologie Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire Laboratoire de l'Accélérateur Linéaire Institut d'Astrophysique de Paris Institut d'astrophysique spatiale Institut d'astrophysique spatiale Institut d'astrophysique spatiale Laboratoire de Physique Subatomique et de Cosmologie Centre National d'Études Spatiales [Toulouse] Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique Laboratoire de l'Accélérateur Linéaire Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Centre d'étude spatiale des rayonnements Centre d'étude spatiale des rayonnements Laboratoire de l'Accélérateur Linéaire AstroParticule et Cosmologie Laboratoire de l'Accélérateur Linéaire Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Institut d'Astrophysique de Paris Centre d'étude spatiale des rayonnements Institut d'astrophysique spatiale Laboratoire de Physique Subatomique et de Cosmologie Centre d'étude spatiale des rayonnements AstroParticule et Cosmologie Laboratoire de Physique Subatomique et de Cosmologie Centre d'étude spatiale des rayonnements Laboratoire de Physique Subatomique et de Cosmologie Institut d'Astrophysique de Paris Institut d'astrophysique spatiale Laboratoire de l'Accélérateur Linéaire Institut d'astrophysique spatiale Département de Physique des Particules (ex SPP) Institut d'astrophysique spatiale
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. The High Frequency Instrument (HFI) is one of the two focal instruments of the Planck mission. It will observe the whole sky in six bands in the 100 GHz-1 THz range. Aims: The HFI instrument is designed to measure the cosmic microwave background (CMB) with a sensitivity limited only by fundamental sources: the photon noise of the CMB itself and the residuals left after the removal of foregrounds. The two high frequency bands will provide full maps of the submillimetre sky, featuring mainly extended and point source foregrounds. Systematic effects must be kept at negligible levels or accurately monitored so that the signal can be corrected. This paper describes the HFI design and its characteristics deduced from ground tests and calibration. Methods: The HFI instrumental concept and architecture are feasible only by pushing new techniques to their extreme capabilities, mainly: (i) bolometers working at 100 mK and absorbing the radiation in grids; (ii) a dilution cooler providing 100 mK in microgravity conditions; (iii) a new type of AC biased readout electronics and (iv) optical channels using devices inspired from radio and infrared techniques. Results: The Planck-HFI instrument performance exceeds requirements for sensitivity and control of systematic effects. During ground-based calibration and tests, it was measured at instrument and system levels to be close to or better than the goal specification.

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Fichiers liés : aa12975-09.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/08/2010
• Auteurs : Florence QuesnelJean-Philippe StormeEmile RocheChantal BourdillonAlina I. IakovlevaJohann SchnyderNoémie BreillatMaud AndréJean-Marc BaeleRobert W. O'B. KnoxPaola IacuminThierry SmithJohan YansChristian Dupuis
• Organismes : Bureau de Recherches Géologiques et Minières FUNDP ERADATA Geological Institute of the Russian Academy of Sciences Paléobiodiversité et paléoenvironnements Biogéosciences [UMR 5561] [Dijon] Biogéosciences [UMR 5561] [Dijon] Dipartimento di Scienze della Terra [Parma] Département de Paléontologie Fondation Universitaire Notre Dame de la Paix Géologie GFA

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Résumé : The geological archives record "hyperthermic" crises, along with their consequences on the biota and physical environment. Among these, the PETM (Paleocene-Eocene Thermal Maximum) is considered as the closest analogue to the current climate crisis due to its global character and the speeds at which the CO2 rate and average temperatures increased. Some 55.8 Ma ago (Aubry et al., 2007), it affected the Earth for a period of almost 200,000 years; the terrestrial and marine paleoenvironments were marked by a negative δ13C anomaly (or Carbon Isotopic Excursion, CIE) coinciding with a negative δ18O anomaly indicative of a drastic temperature rise (+ 3 to + 8 °C). The causes envisaged to explain the major global disturbances of the atmosphere and oceans are linked with the massive emission of 12C-enriched greenhouse gases whose origins are still debated and probably multiple. Moreover the PETM left a deep and long-lasting imprint on the living animal and plant world, both terrestrial and marine. The preserved paleoenvironments of the sedimentary record also show a recrudescence of clastic influx or are distinguished by specific sediments such as coal and lignite, phosphates, black shales, diatomites, etc. The shallow to deep marine environments from all the paleolatitudes have been studied intensively, the data collected allowing to refine climate models and ocean/atmosphere responses. However, the terrestrial record was seldom examined and very few studies aimed at checking if the drastic rises of greenhouse gases and temperature had a real impact on the fluvial, lacustrine, palustrine sediments and on the paleosols and weathering profiles development during the PETM. Apart notable paleontological studies, its impact on the terrestrial realm at a regional scale and on different interconnected contemporary paleoenvironments has probably not been studied and integrated enough (Zachos et al., 2008). We propose such a regional study in the Sparnacian facies of the Paris Basin. To ensure correlation of the events and processes identified with a confidence level as precise as possible, high resolution temporal framework is essential. Historically, the Paris and adjacent basins are the cradle of stratigraphy, where the notion of "Sparnacian" took shape (Dollfus 1880), pointing terrestrial to brackish deposits with particular facies and faunas, interstratified between two easily distinguishable Late Paleocene (Thanetian) and Early Eocene (Ypresian) mainly sandy and marine formations. Since that time stratigraphy has evolved, especially regarding the Paleocene and Eocene epochs, and we refer to the lithostratigraphies of Aubry et al. (2005) and Steurbaut (1998) for the Paris and Belgian Basins. In Avesnois, close to Belgium, the Paleocene and Eocene lithostratigraphy has been revised thanks to a geological mapping project supported by drillings (Quesnel, 2006). Detailed sampling and various analyses have been performed: granulometry and XRD mineralogy, heavy mineral assemblages, carbonate and organic carbon contents, biostratigraphy, palynofacies, pyrolyse rock-eval, and chemostratigraphy (d13C of the dispersed organic matter). In the AVE 007 drilling (Mormal Forest), the CIE has been identified in a lignitic clay. The clay content is dominated by the illite-smectite mixed layers, with 10 to 20 % of illite and kaolinite. The palynological study of the pollen and spores assemblages confirms the Early Eocene age. The Paleocene markers are absent and using the palynozonation of Roche et al. (2009), the lignitic clay can be correlated to the lower part of the Tienen Fm and to the SP3 to SP4 units of the Cap d'Ailly section. The depositional environment is palustrine-lacustrine, with sporo-pollen fluvial inputs from the hinterland in a humid subtropical climate. The lignitic clay overlies fluvial flint gravels and sands, above the Coniacian chalk. Those clastic deposits contain mainly illite-smectite mixed layers, a few kaolinite and illite and are richer in pyrite downwards. Paleocene pollens and dinocysts are present. The onset of the CIE is recorded at the top of this sandy unit, below the lignitic clay. Those fluvial flint gravels and sands are widespread in Avesnois, and named “Cailloutis à silex de Mormal” (new name) and “Sables et Grès du Quesnoy”. The lignitic clay corresponds to a palustrine deposit, filling the fluvial channel after the river bed migration. Similar units are well known in northern France and Belgium, they belong to the Upper Landenian fluvial sands, often display cross stratification, paleoweathering (oxidation and/or silcrete), lignite or marl lenses, vertebrate fauna and sometimes a rich flora in silicified slabs or beds. They can be attributed to the Tienen Fm. Similar sandy, clayey and lignitic units are also recognized southwards in the Paris Basin, in the first clastic units of the Mortemer Fm. In Northern France and Belgium those terrestrial units often cap or incise Upper Thanetian marine sands. In Avesnois the latter are named “Sables verts de l'Avesnois” and correlated to the “Sables de Grandglise” (NP8) and “Sables de Bois Gilles” (NP9). In the western part of the Avesnois, the AVE 31 drilling has yielded a shallow marine shelly sand (“Falun de Viesly”), with Upper Thanetian benthic foraminifera (P4c to P5), and a shelly clay (“Argile de Louvil”), containing Thanetian benthic foraminifera (P4). They are overlain by a sandy laminated clay (“Tuffeau de Valenciennes”), then a laminated silt at the top. In the AVE007 drilling, the lignitic clay is also overlain by a silty laminated unit, containing the same clay minerals as the clay plus chlorite and vermiculite at the top. Lower Ypresian dinocysts (Wetzeliella sp.), phytoliths, rootlets moulds and agglutinated foraminifera similar to those contained in the Orchies Clay (NP10 – NP 11?) are present. That silty unit is widespread in Avesnois and Valenciennois. We name it “Silt et Sablon de l'Avesnois” and we correlate it to a part of the Kortrijk Clay Fm in the Ieper Gp. The new units described around the Paleocene-Eocene boundary in Avesnois allow correlation between the Belgian and Paris Basins and help to precise the landscape evolution during this critical interval. The PETM record has also been recently identified around 80km southwestwards, at Sinceny (Aisne), a key locality for the Sparnacian facies. The data obtained in this drilling will be presented and compared to those obtained in Avesnois and integrated in the Paris Basin stratigraphic framework.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2010
• Auteurs : Audrey SimonMichel Péoc’hPhilippe CasassusErick DeconinckPhilippe ColombatBernard DesablensOlivier TournilhacHouchingue EghbaliCh FoussardJerome JaubertJean-Pierre VilqueJean François RossiVirginie LucasVincent DelwailAntoine ThyssFrederic MoloiselNoel MilpiedSteven Le GouillThierry LamyRémy Gressin
• Organismes : Hematology antomie pathologique Service d'hématologie clinique [Avicenne] Haematology Service d'hématologie [Tours] Laboratoire d'Hématologie [CHU Amiens] Clinical Haematology Hematologie Haematology Hematology Université de Reims Champagne-Ardenne Haematology Oncology Haematology Haematology Haematology Haematology Service d'hématologie clinique Haematology Hematology
• Publié dans British Journal of Haematology le 29/10/2020

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Résumé : Peripheral T-Cell lymphomas (PTCL) are relatively rare diseases but appear as highly aggressive and display worse remission and survival rates than B-cell lymphomas. Despite non satisfactory results with the CHOP regimen, it remains the reference front line therapy in these diseases, but has not been challenged in phase III trials. The GOELAMS group devised an alternative therapeutic schedule including Etoposide, Ifosfamide, Cisplatin alternating with Doxorubicin, Bleomycin, Vinblastin, Dacarbazine (VIP-reinforced-ABVD) and compared it to CHOP/21 as front-line treatment in non cutaneous PTCL. All newly diagnosed patients were eligible. The primary objective was to improve the 2-years event-free survival (EFS) rate. Secondary objectives were to compare the response rates, overall survival, and toxicities as well as identify prognostic factors. 88 patients were identified between 1996 and 2002. Both arms were well balanced for patients' characteristics in terms of histological and clinical presentation. No significant difference was observed between the two arms in terms of 2-years EFS. ALCL type and Ann Arbor stage I-II were identified as two independent favourable prognostic factors influencing survival. The VIP-rABVD regimen was not superior to CHOP/21 in term of EFS as first-line treatment of PTCL, confirming that CHOP/21 remains the reference arm in these lymphomas.

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Fichiers liés : PEER_stage2_10.1111%2Fj.1365-2141.2010.08329.x.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/08/2010
• Auteurs : Joffrey MoirouxCecile Le LannJean-Sébastien PierrePhilippe VernonJoan van BaarenJacques J.M. J.M. van Alphen
• Organismes : Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Paysages, Changements Climatique, Biodiversité

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/08/2010
• Auteurs : Philippe FoucherJean-Philippe TarelBahman SoheilianPierre CharbonnierNicolas PaparoditisRachid Belaroussi
• Organismes : Centre d'études techniques de l'équipement Est Laboratoire Exploitation, Perception, Simulateurs et Simulations Méthodes d'Analyses pour le Traitement d'Images et la Stéréorestitution Centre d'études techniques de l'équipement Est Méthodes d'Analyses pour le Traitement d'Images et la Stéréorestitution Laboratoire Exploitation, Perception, Simulateurs et Simulations

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Résumé : Road sign identification in images is an important issue, in particular for vehicle safety applications. It is usually tackled in three stages : detection, recognition and tracking, and evaluated as a whole. To progress towards better algorithms, we focus in this paper on the first stage of the process, namely road sign detection. More specifically, we compare, on the same ground-truth image database, results obtained by three algorithms that sample different state-of-the-art approaches. The three tested algorithms : Contour Fitting, Radial Symmetry Transform, and pair-wise voting scheme, all use color and edge information and are based on geometrical models of road signs. The test dataset is made of 847 images 960x1080 of complex urban scenes (available at www.itowns.fr/benchmarking.html). They feature 251 road signs of different shapes (circular, rectangular, triangular), sizes and types. The pros and cons of the three algorithms are discussed, allowing to draw new research perspectives.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 22/08/2010
• Auteurs : Samuel DequiedtNicolas Chemidlin Prévost-BouréNicolas P. A. SabyJean ThioulouseMélanie M. LelievreClaudy JolivetPierre-Alain MaronManuel P MartinDominique ArrouaysPhilippe LemanceauLionel Ranjard
• Organismes : Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement InfoSol Ecologie quantitative et évolutive des communautés [LBBE] Microbiologie du Sol et de l'Environnement InfoSol Microbiologie du Sol et de l'Environnement InfoSol InfoSol Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement

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Résumé : Ecologists studying plant and animals have long recognized that the modifications of diversity across a landscape are central for understanding the environmental factors driving the magnitude and the variability of community assembly. Despite the statement that this conceptual vision is also relevant for microorganisms, since it can offer valuable insights into the relative influence of dispersal limitations, environmental heterogeneity, and environmental and evolutionary changes in shaping the structure of ecological communities, studies integrating wide spatial scale have been poorly investigated and the environmental filters structuring microbial biodiversity remain largely unknown. In this context, we have investigated the characterisation of indigenous microbial communities from soils sampled on a broad scale. This characterisation relied on analyses of density, diversity and genetic structure of microbial communities by using molecular tools directly on DNA extracted from the soil library of RMQS ("Rseau de Mesures de la Qualit des Sols" = French soil quality monitoring network) which cross-rules all the French territory with about 2,200 soils sampled. Geo-positioning, physico-chemical characteristics, climatic factors, floristic composition and land use of these soils were also recorded. The geostatistical interpolation of soil microbial density and diversity revealed a heterogeneous distribution of microbial communities on a wide extent which is spatially structured in bio geographical patterns. Microbial density and diversity seems to be more influenced by local filters such as soil properties and land use but is relatively independent of global filters such as climatic factors or the presence of natural barriers. Our study confirms that the biogeography of microorganisms differs fundamentally from the biogeography of "macro-organisms" and that soil management can have significant large-scale effects.

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Fichiers liés : PS23_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/08/2010
• Auteurs : Fabrice JardinJean-Philippe JaisThierry-Jo MolinaFrançoise ParmentierJean-Michel PicquenotPhilippe RuminyHervé TillyChristian BastardGilles-André SallesPierre FeugierCatherine ThieblemontChristian GisselbrechtAurélien de ReynièsBertrand CoiffierCorinne HaiounKaren Leroy
• Organismes : Groupe d'étude des proliférations lymphoïdes Département d'Hématologie Service informatique médicale et biostatistique Département de Pathologie Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Service d'Hématologie Laboratoire de Biologie Moléculaire de la Cellule Service d'Hématologie [CHRU Nancy] Service d'hématologie-oncologie adultes Service d'hématologie-oncologie adultes "Cartes d'Identité des Tumeurs " Service d'Hématologie Laboratoire de Biologie Moléculaire de la Cellule Service d'hématologie clinique Service d'hématologie clinique Institut Mondor de Recherche Biomédicale
• Publié dans Blood le 28/10/2020

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Résumé : Genomic alterations play a crucial role in the development and progression of diffuse large B-cell lymphomas (DLBCLs). We determined gene copy number alterations (GCNAs) of TP53, CDKN2A, CDKN1B, BCL2, MYC, REL, and RB1 with a single polymerase chain reaction (PCR) assay (quantitative multiplex PCR of short fragments [QMPSF]) in a cohort of 114 patients with DLBCL to assess their prognostic value and relationship with the gene expression profile. Losses of TP53 and CDKN2A, observed in 8% and 35% of patients, respectively, were significantly associated with a shorter survival after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment, independently of the International Prognostic Index and of the cell of origin. Analysis of the 9p21 genomic region indicated that transcripts encoding p14ARF and p16INK4A were both disrupted in most patients with CDKN2A deletion. These patients predominantly had an activated B-cell profile and showed a specific gene expression signature, characterized by dysregulation of the RB/E2F pathway, activation of cellular metabolism, and decreased immune and inflammatory responses. These features may constitute the molecular basis sustaining the unfavorable outcome and chemoresistance of this DLBCL subgroup. Detection of TP53 and CDKN2A loss by QMPSF is a powerful tool that could be used for patient stratification in future clinical trials.

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