Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/08/2010
• Auteurs : Florence QuesnelJean-Philippe StormeEmile RocheChantal BourdillonAlina I. IakovlevaJohann SchnyderNoémie BreillatMaud AndréJean-Marc BaeleRobert W. O'B. KnoxPaola IacuminThierry SmithJohan YansChristian Dupuis
• Organismes : Bureau de Recherches Géologiques et Minières FUNDP ERADATA Geological Institute of the Russian Academy of Sciences Paléobiodiversité et paléoenvironnements Biogéosciences [UMR 5561] [Dijon] Biogéosciences [UMR 5561] [Dijon] Dipartimento di Scienze della Terra [Parma] Département de Paléontologie Fondation Universitaire Notre Dame de la Paix Géologie GFA

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Résumé : The geological archives record "hyperthermic" crises, along with their consequences on the biota and physical environment. Among these, the PETM (Paleocene-Eocene Thermal Maximum) is considered as the closest analogue to the current climate crisis due to its global character and the speeds at which the CO2 rate and average temperatures increased. Some 55.8 Ma ago (Aubry et al., 2007), it affected the Earth for a period of almost 200,000 years; the terrestrial and marine paleoenvironments were marked by a negative δ13C anomaly (or Carbon Isotopic Excursion, CIE) coinciding with a negative δ18O anomaly indicative of a drastic temperature rise (+ 3 to + 8 °C). The causes envisaged to explain the major global disturbances of the atmosphere and oceans are linked with the massive emission of 12C-enriched greenhouse gases whose origins are still debated and probably multiple. Moreover the PETM left a deep and long-lasting imprint on the living animal and plant world, both terrestrial and marine. The preserved paleoenvironments of the sedimentary record also show a recrudescence of clastic influx or are distinguished by specific sediments such as coal and lignite, phosphates, black shales, diatomites, etc. The shallow to deep marine environments from all the paleolatitudes have been studied intensively, the data collected allowing to refine climate models and ocean/atmosphere responses. However, the terrestrial record was seldom examined and very few studies aimed at checking if the drastic rises of greenhouse gases and temperature had a real impact on the fluvial, lacustrine, palustrine sediments and on the paleosols and weathering profiles development during the PETM. Apart notable paleontological studies, its impact on the terrestrial realm at a regional scale and on different interconnected contemporary paleoenvironments has probably not been studied and integrated enough (Zachos et al., 2008). We propose such a regional study in the Sparnacian facies of the Paris Basin. To ensure correlation of the events and processes identified with a confidence level as precise as possible, high resolution temporal framework is essential. Historically, the Paris and adjacent basins are the cradle of stratigraphy, where the notion of "Sparnacian" took shape (Dollfus 1880), pointing terrestrial to brackish deposits with particular facies and faunas, interstratified between two easily distinguishable Late Paleocene (Thanetian) and Early Eocene (Ypresian) mainly sandy and marine formations. Since that time stratigraphy has evolved, especially regarding the Paleocene and Eocene epochs, and we refer to the lithostratigraphies of Aubry et al. (2005) and Steurbaut (1998) for the Paris and Belgian Basins. In Avesnois, close to Belgium, the Paleocene and Eocene lithostratigraphy has been revised thanks to a geological mapping project supported by drillings (Quesnel, 2006). Detailed sampling and various analyses have been performed: granulometry and XRD mineralogy, heavy mineral assemblages, carbonate and organic carbon contents, biostratigraphy, palynofacies, pyrolyse rock-eval, and chemostratigraphy (d13C of the dispersed organic matter). In the AVE 007 drilling (Mormal Forest), the CIE has been identified in a lignitic clay. The clay content is dominated by the illite-smectite mixed layers, with 10 to 20 % of illite and kaolinite. The palynological study of the pollen and spores assemblages confirms the Early Eocene age. The Paleocene markers are absent and using the palynozonation of Roche et al. (2009), the lignitic clay can be correlated to the lower part of the Tienen Fm and to the SP3 to SP4 units of the Cap d'Ailly section. The depositional environment is palustrine-lacustrine, with sporo-pollen fluvial inputs from the hinterland in a humid subtropical climate. The lignitic clay overlies fluvial flint gravels and sands, above the Coniacian chalk. Those clastic deposits contain mainly illite-smectite mixed layers, a few kaolinite and illite and are richer in pyrite downwards. Paleocene pollens and dinocysts are present. The onset of the CIE is recorded at the top of this sandy unit, below the lignitic clay. Those fluvial flint gravels and sands are widespread in Avesnois, and named “Cailloutis à silex de Mormal” (new name) and “Sables et Grès du Quesnoy”. The lignitic clay corresponds to a palustrine deposit, filling the fluvial channel after the river bed migration. Similar units are well known in northern France and Belgium, they belong to the Upper Landenian fluvial sands, often display cross stratification, paleoweathering (oxidation and/or silcrete), lignite or marl lenses, vertebrate fauna and sometimes a rich flora in silicified slabs or beds. They can be attributed to the Tienen Fm. Similar sandy, clayey and lignitic units are also recognized southwards in the Paris Basin, in the first clastic units of the Mortemer Fm. In Northern France and Belgium those terrestrial units often cap or incise Upper Thanetian marine sands. In Avesnois the latter are named “Sables verts de l'Avesnois” and correlated to the “Sables de Grandglise” (NP8) and “Sables de Bois Gilles” (NP9). In the western part of the Avesnois, the AVE 31 drilling has yielded a shallow marine shelly sand (“Falun de Viesly”), with Upper Thanetian benthic foraminifera (P4c to P5), and a shelly clay (“Argile de Louvil”), containing Thanetian benthic foraminifera (P4). They are overlain by a sandy laminated clay (“Tuffeau de Valenciennes”), then a laminated silt at the top. In the AVE007 drilling, the lignitic clay is also overlain by a silty laminated unit, containing the same clay minerals as the clay plus chlorite and vermiculite at the top. Lower Ypresian dinocysts (Wetzeliella sp.), phytoliths, rootlets moulds and agglutinated foraminifera similar to those contained in the Orchies Clay (NP10 – NP 11?) are present. That silty unit is widespread in Avesnois and Valenciennois. We name it “Silt et Sablon de l'Avesnois” and we correlate it to a part of the Kortrijk Clay Fm in the Ieper Gp. The new units described around the Paleocene-Eocene boundary in Avesnois allow correlation between the Belgian and Paris Basins and help to precise the landscape evolution during this critical interval. The PETM record has also been recently identified around 80km southwestwards, at Sinceny (Aisne), a key locality for the Sparnacian facies. The data obtained in this drilling will be presented and compared to those obtained in Avesnois and integrated in the Paris Basin stratigraphic framework.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/08/2010
• Auteurs : Joffrey MoirouxCecile Le LannJean-Sébastien PierrePhilippe VernonJoan van BaarenJacques J.M. J.M. van Alphen
• Organismes : Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Paysages, Changements Climatique, Biodiversité

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• Type de publi. : Article dans une revue
• Date de publi. : 25/08/2010
• Auteurs : Audrey SimonMichel Péoc’hPhilippe CasassusErick DeconinckPhilippe ColombatBernard DesablensOlivier TournilhacHouchingue EghbaliCh FoussardJerome JaubertJean-Pierre VilqueJean François RossiVirginie LucasVincent DelwailAntoine ThyssFrederic MoloiselNoel MilpiedSteven Le GouillThierry LamyRémy Gressin
• Organismes : Hematology antomie pathologique Service d'hématologie clinique [Avicenne] Haematology Service d'hématologie [Tours] Laboratoire d'Hématologie [CHU Amiens] Clinical Haematology Hematologie Haematology Hematology Université de Reims Champagne-Ardenne Haematology Oncology Haematology Haematology Haematology Haematology Service d'hématologie clinique Haematology Hematology
• Publié dans British Journal of Haematology le 29/10/2020

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Résumé : Peripheral T-Cell lymphomas (PTCL) are relatively rare diseases but appear as highly aggressive and display worse remission and survival rates than B-cell lymphomas. Despite non satisfactory results with the CHOP regimen, it remains the reference front line therapy in these diseases, but has not been challenged in phase III trials. The GOELAMS group devised an alternative therapeutic schedule including Etoposide, Ifosfamide, Cisplatin alternating with Doxorubicin, Bleomycin, Vinblastin, Dacarbazine (VIP-reinforced-ABVD) and compared it to CHOP/21 as front-line treatment in non cutaneous PTCL. All newly diagnosed patients were eligible. The primary objective was to improve the 2-years event-free survival (EFS) rate. Secondary objectives were to compare the response rates, overall survival, and toxicities as well as identify prognostic factors. 88 patients were identified between 1996 and 2002. Both arms were well balanced for patients' characteristics in terms of histological and clinical presentation. No significant difference was observed between the two arms in terms of 2-years EFS. ALCL type and Ann Arbor stage I-II were identified as two independent favourable prognostic factors influencing survival. The VIP-rABVD regimen was not superior to CHOP/21 in term of EFS as first-line treatment of PTCL, confirming that CHOP/21 remains the reference arm in these lymphomas.

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Fichiers liés : PEER_stage2_10.1111%2Fj.1365-2141.2010.08329.x.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/08/2010
• Auteurs : Philippe FoucherJean-Philippe TarelBahman SoheilianPierre CharbonnierNicolas PaparoditisRachid Belaroussi
• Organismes : Centre d'études techniques de l'équipement Est Laboratoire Exploitation, Perception, Simulateurs et Simulations Méthodes d'Analyses pour le Traitement d'Images et la Stéréorestitution Centre d'études techniques de l'équipement Est Méthodes d'Analyses pour le Traitement d'Images et la Stéréorestitution Laboratoire Exploitation, Perception, Simulateurs et Simulations

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Résumé : Road sign identification in images is an important issue, in particular for vehicle safety applications. It is usually tackled in three stages : detection, recognition and tracking, and evaluated as a whole. To progress towards better algorithms, we focus in this paper on the first stage of the process, namely road sign detection. More specifically, we compare, on the same ground-truth image database, results obtained by three algorithms that sample different state-of-the-art approaches. The three tested algorithms : Contour Fitting, Radial Symmetry Transform, and pair-wise voting scheme, all use color and edge information and are based on geometrical models of road signs. The test dataset is made of 847 images 960x1080 of complex urban scenes (available at www.itowns.fr/benchmarking.html). They feature 251 road signs of different shapes (circular, rectangular, triangular), sizes and types. The pros and cons of the three algorithms are discussed, allowing to draw new research perspectives.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 22/08/2010
• Auteurs : Samuel DequiedtNicolas Chemidlin Prévost-BouréNicolas P. A. SabyJean ThioulouseMélanie M. LelievreClaudy JolivetPierre-Alain MaronManuel P MartinDominique ArrouaysPhilippe LemanceauLionel Ranjard
• Organismes : Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement InfoSol Ecologie quantitative et évolutive des communautés [LBBE] Microbiologie du Sol et de l'Environnement InfoSol Microbiologie du Sol et de l'Environnement InfoSol InfoSol Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement

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Résumé : Ecologists studying plant and animals have long recognized that the modifications of diversity across a landscape are central for understanding the environmental factors driving the magnitude and the variability of community assembly. Despite the statement that this conceptual vision is also relevant for microorganisms, since it can offer valuable insights into the relative influence of dispersal limitations, environmental heterogeneity, and environmental and evolutionary changes in shaping the structure of ecological communities, studies integrating wide spatial scale have been poorly investigated and the environmental filters structuring microbial biodiversity remain largely unknown. In this context, we have investigated the characterisation of indigenous microbial communities from soils sampled on a broad scale. This characterisation relied on analyses of density, diversity and genetic structure of microbial communities by using molecular tools directly on DNA extracted from the soil library of RMQS ("Rseau de Mesures de la Qualit des Sols" = French soil quality monitoring network) which cross-rules all the French territory with about 2,200 soils sampled. Geo-positioning, physico-chemical characteristics, climatic factors, floristic composition and land use of these soils were also recorded. The geostatistical interpolation of soil microbial density and diversity revealed a heterogeneous distribution of microbial communities on a wide extent which is spatially structured in bio geographical patterns. Microbial density and diversity seems to be more influenced by local filters such as soil properties and land use but is relatively independent of global filters such as climatic factors or the presence of natural barriers. Our study confirms that the biogeography of microorganisms differs fundamentally from the biogeography of "macro-organisms" and that soil management can have significant large-scale effects.

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Fichiers liés : PS23_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/08/2010
• Auteurs : Marie-Anne Lelu-WalterCécile GrondinLudovic BonhommeMichel VallanceDomenico MorabitoPhilippe LabelCaroline Teyssier
• Organismes : Unité de recherche Amélioration, Génétique et Physiologie Forestières Institut Jean-Pierre Bourgin Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Unité de recherche Amélioration, Génétique et Physiologie Forestières Arbres et Réponses aux Contraintes Hydriques et Environnementales Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières

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Résumé : Somatic embryogenesis represents an important clonal propagation method for conifers (Lelu-Walter and Pâques 2009). Desiccation treatments applied to hybrid larch somatic embryos promote plantlet development (Lelu et al. 1995). Water availability could also be modulated via the gelling agents of the culture medium. We investigated the effect of high gellan gum concentration in the medium during somatic embryo maturation of hydrid larch. High gellan gum concentration of 8 gL-1 was compared to the normal concentration of 4 gL-1 at different stages of maturation. The decrease of water availability at 8 weeks on 8 gL-1 impacted osmotic potential, water content and dry weight in the embryos. The proteomic study at 1 and 8 weeks on both culture media, indicated that 62 differing proteins at 1 week corresponded to “Carbohydrate metabolism”, “Genetic information processing” or "Environmental information processing”. The physiological parameters as well as the identified proteins suggested a stress status of the embryos when they were cultivated on 4 gL-1. We report results that describe for the first time 2-DE proteomic analysis somatic embryo maturation in larch. The protein expression profiles will provide novel insights into the process of hybrid larch somatic embryo maturation, and an outline for practical application.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/08/2010
• Auteurs : Fabrice JardinJean-Philippe JaisThierry-Jo MolinaFrançoise ParmentierJean-Michel PicquenotPhilippe RuminyHervé TillyChristian BastardGilles-André SallesPierre FeugierCatherine ThieblemontChristian GisselbrechtAurélien de ReynièsBertrand CoiffierCorinne HaiounKaren Leroy
• Organismes : Groupe d'étude des proliférations lymphoïdes Département d'Hématologie Service informatique médicale et biostatistique Département de Pathologie Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Groupe d'étude des proliférations lymphoïdes Service d'Hématologie Laboratoire de Biologie Moléculaire de la Cellule Service d'Hématologie [CHRU Nancy] Service d'hématologie-oncologie adultes Service d'hématologie-oncologie adultes "Cartes d'Identité des Tumeurs " Service d'Hématologie Laboratoire de Biologie Moléculaire de la Cellule Service d'hématologie clinique Service d'hématologie clinique Institut Mondor de Recherche Biomédicale
• Publié dans Blood le 28/10/2020

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Résumé : Genomic alterations play a crucial role in the development and progression of diffuse large B-cell lymphomas (DLBCLs). We determined gene copy number alterations (GCNAs) of TP53, CDKN2A, CDKN1B, BCL2, MYC, REL, and RB1 with a single polymerase chain reaction (PCR) assay (quantitative multiplex PCR of short fragments [QMPSF]) in a cohort of 114 patients with DLBCL to assess their prognostic value and relationship with the gene expression profile. Losses of TP53 and CDKN2A, observed in 8% and 35% of patients, respectively, were significantly associated with a shorter survival after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment, independently of the International Prognostic Index and of the cell of origin. Analysis of the 9p21 genomic region indicated that transcripts encoding p14ARF and p16INK4A were both disrupted in most patients with CDKN2A deletion. These patients predominantly had an activated B-cell profile and showed a specific gene expression signature, characterized by dysregulation of the RB/E2F pathway, activation of cellular metabolism, and decreased immune and inflammatory responses. These features may constitute the molecular basis sustaining the unfavorable outcome and chemoresistance of this DLBCL subgroup. Detection of TP53 and CDKN2A loss by QMPSF is a powerful tool that could be used for patient stratification in future clinical trials.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/08/2010
• Auteurs : Corinne LoeuilletPierre-Yves BoëlleCatherine Lemaire-VieilleMarie BaldazzaPhilippe NaquetPierre ChambonM.F. Cesbron-DelauwAlain-Jacques ValleronJean GagnonJean-Yves Cesbron
• Organismes : Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Epidémiologie des maladies infectieuses et modélisation Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Centre d'Immunologie de Marseille - Luminy Institut de Génétique et de Biologie Moléculaire et Cellulaire Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Epidémiologie des maladies infectieuses et modélisation Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble]
• Publié dans Journal of Infectious Diseases le 27/10/2020

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Résumé : Sex effect on the incubation period of variant Creutzfeldt-Jakob disease (vCJD) disease in human and ME-7 murine models was investigated. In the 167 vCJD cases reported in the United Kingdom as of January 2009, age at onset was significantly lower in female patients (by 2 years) than in male patients after stratification on birth cohort. In C57/Bl6N mice infected with ME-7 scrapie strain, incubation was shorter in female than in male mice. The incubation period increased in castrated male mice after intraperitoneal infection but not after intracerebral inoculation. In the absence of androgen receptors, the incubation period for prion disease increased after intraperitoneal inoculation. In ovariectomized or estrogen receptor alpha-defective female mice, no effect was observed on the incubation period of mouse prion disease. These results show that androgens influence the prion diseases incubation period after inoculation at a peripheral site.

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• Type de publi. : Article dans une revue
• Date de publi. : 07/08/2010
• Auteurs : Angèle RicolleauJean-Philippe PerrillatGuillaume FiquetIsabelle DanielJan MatasAhmed AddadN. MenguyHervé CardonMohamed MezouarNicolas Guignot
• Organismes : Institut de minéralogie et de physique des milieux condensés Laboratoire de Sciences de la Terre Institut de minéralogie et de physique des milieux condensés Laboratoire de Sciences de la Terre Laboratoire de Sciences de la Terre Laboratoire de structures et propriétés de l'état solide - UMR 8008 Institut de minéralogie et de physique des milieux condensés Laboratoire de Sciences de la Terre European Synchrotron Radiation Facility European Synchrotron Radiation Facility
• Publié dans Journal of Geophysical Research : Solid Earth le 27/10/2020

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Résumé : The phase relations and density of a natural mid‐ocean ridge basalt (MORB) were investigated from 28 to 89 GPa and 1600 to 2700 K by in situ X‐ray diffraction measurements and chemical analysis of the quenched samples using transmission electron microscopy (TEM). We observed an assemblage of five phases up to 50 GPa, namely an aluminum‐bearing magnesium perovskite phase, a calcium perovskite phase, a stishovite phase, the new aluminum‐rich (NAL) phase, and a calcium ferrite‐type phase. The NAL phase was no longer observed above 50 GPa. The phase proportions were obtained by Rietveld refinement of the in situ X‐ray diffraction patterns. After the disappearance of the NAL phase beyond 50 GPa, the proportion of each phase remains constant up to 89 GPa. The density of MORB was calculated using the measured volumes, phase proportions, and chemical compositions of the coexisting phases. The thermoelastic parameters of the MORB sample were estimated from the fit of the measured densities at various pressure and temperature conditions. Resulting MORB density profiles were calculated for different subducting slab temperature profiles. MORB densities are 0.5% to 2% greater than those of the surrounding mantle over the entire lower mantle range, suggesting MORB likely subducts to the core-mantle boundary

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Fichiers liés : 2009JB006709.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/08/2010
• Auteurs : Hélène GilbertYvon BillonHervé LagantJulia Adriana CalderonPhilippe GuillouetJean Pierre BidanelJean NobletPierre SellierSusanne Hermesch
• Organismes : Génétique Animale et Biologie Intégrative Génétique Expérimentale en Productions Animales Génétique Animale et Biologie Intégrative Génétique Animale et Biologie Intégrative Insémination Caprine et Porcine Génétique Animale et Biologie Intégrative Systèmes d'élevage, nutrition animale et humaine Génétique Animale et Biologie Intégrative Animal Genetics and Breeding Unit

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Résumé : absent

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Fichiers liés : 33961_20101026063444703_1.pdf

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