Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/07/2010
• Auteurs : Philippe LescoatThierry BonaudoLuis MiorP. BommelJean LossouarnRené Poccard-Chapuis
• Organismes : Unité de Recherches Avicoles Sciences pour l'Action et le Développement : Activités, Produits, Territoires Agricultural Research and Rural Extension Company of Santa Catarina = Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina Centre de Coopération Internationale en Recherche Agronomique pour le Développement Sciences pour l'Action et le Développement : Activités, Produits, Territoires Centre de Coopération Internationale en Recherche Agronomique pour le Développement

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Résumé : Poultry production chain is an integrated sector seen as “off land”. However this chain is strongly interacting with territories leading to various impacts. Therefore to deal with sustainability requires transdisciplinarity. The first step is to define the studied dynamic system, here the “poultry production chain county” aggregate. The second is to share between disciplines a common knowledge on this system through a unique representation. The third is to accept the approaches proposed by other disciplines even though time and space scales are consequently evolving. Due to the approach complexity, fruitful but time‐consuming transactions between researchers are observed.

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Fichiers liés : 2010_Thierry Bonaudo_IFSA_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/07/2010
• Auteurs : Jasmine BurguetJessica SchwarzOlivier RampinGilles FromentinPhilippe AndreyDaniel ToméYves MaurinNicolas Darcel
• Organismes : Institut Jean-Pierre Bourgin Ingredia Physiologie de la Nutrition et du Comportement Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire Institut Jean-Pierre Bourgin Université Paris Saclay (COmUE) Physiologie de la Nutrition et du Comportement Alimentaire Neurobiologie de l'Olfaction et de la Prise Alimentaire Physiologie de la Nutrition et du Comportement Alimentaire

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/07/2010
• Auteurs : Philippe AndreyEric BiotJasmine BurguetYves Maurin
• Organismes : Neurobiologie de l'Olfaction et de la Prise Alimentaire Université Pierre et Marie Curie - Paris 6 Laboratoire de biologie cellulaire et moléculaire Institut Jean-Pierre Bourgin - Sciences du végétal Neurobiologie de l'Olfaction et de la Prise Alimentaire

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/07/2010
• Auteurs : J. A. E. van GijselD. P. J. SwartJean-Luc BarayHassan BencherifH. ClaudeT. FehrJ. GumbelSophie Goodin-BeekmannG. H. HansenPhilippe KeckhutE. J. KwiatkowskaT. LeblancI. S. McdermidH. NakaneE. J. QuelK. StebelW. SteinbrechtK. B. StrawbridgeB. I. TatarovE. A. Wolfram
• Organismes : National Institute for Public Health and the Environment [Bilthoven] National Institute for Public Health and the Environment [Bilthoven] Laboratoire de physique de l'atmosphère Laboratoire de physique de l'atmosphère Deutscher Wetterdienst [Offenbach] European Space Research Institute Department of Meteorology [Stockholm] STRATO - LATMOS Norwegian Institute for Air Research STRATO - LATMOS European Space Research and Technology Centre Jet Propulsion Laboratory Jet Propulsion Laboratory National Institute for Public Health and the Environment [Bilthoven] Centro de Investigaciones en Láseres y Aplicaciones [Buenos Aires] Norwegian Institute for Air Research Deutscher Wetterdienst [Offenbach] Environment and Climate Change Canada National Institute for Environmental Studies Centro de Investigaciones en Láseres y Aplicaciones [Buenos Aires]

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Résumé : The Satellite validation with lidar (VALID) project supports the long-term multi-mission validation of atmospheric chemistry and physics instruments with ground-based lidars. VALID involves lidar stations around the world measuring stratospheric ozone and temperature profiles, and tropospheric aerosol and cloud properties. Currently around ten thousand lidar profiles have been made available for validation purposes in VALID and its predecessor EQUAL (ENVISAT quality assessment with lidar). The satellite data under investigation here are the ozone and temperature profiles delivered by the MIPAS (Michelson interferometer for passive atmospheric sounding) and SCIAMACHY (Scanning imaging absorption spectrometer for atmospheric chartography) instruments as new algorithms have become available recently. We have collocated the satellite profiles with the lidar measurements and analysed the comparison results for dependence on several geophysical and instrument observational parameters. Results for the delta validation are presented for SCIAMACHY level 2 version 5.01 and for MIPAS level 2 version ORM (optimised retrieval model) 5.0x. For the SCIAMACHY validation, additional ozone sonde and microwave radiometer data have been included to enlarge the validation dataset. The consistent underestimation of the ozone concentrations by SCIAMACHY seen in version 3.01 is now removed. In the mid-latitudes, SCIAMACHY version 5.01 matches the validation instruments within 5% up to 38 km altitude. The cloud free data are more positively biased. In the polar regions, there is a variable bias ranging from -10% to +7% in the altitude range 15 to 35 km, increasing above (its magnitude depending on validation instrument). The cloud free data have a more enhanced negative bias. In the tropics, there is positive bias in SCIAMACHY v5.01 (5 to 23%) and the cloud free data appear to have a more positive bias (few percent). The large deviation at low altitudes could be due to sub-visual cirrus and will be further investigated in the future. Finally, with respect to the observation direction (corresponding to the scan angle), Eastern orientated profiles overall have a more negative bias than Western profiles For the MIPAS version 5.0x data, the ozone profiles match the lidar data very well over a large part of the compared altitudes. Deviations are seen at the bottom of the profiles starting with a positive bias when going down below the ozone maxima reaching up to +5%. In the tropics this bias changes sign when reaching the lower most altitudes and gets to -10%. At the highest altitudes there is a positive bias in the tropics (max. 2%) and in the mid-latitudes (max. 5%), whereas in the polar region there is an increasing underestimation from an altitude of 35 km (close to 0%) towards the top at 45 km (nearly 15%). The temperature data are mostly within 1 to 2 K from the lidar data. Looking at the different altitude axis, we cannot say that using the engineering altitudes gives a better performance than when using the corrected altitude axis. In fact, the comparison improves when introducing a shift of +500 m for the MIPAS data in the polar region and mid-latitudes (larger shift needed for the tropics). This is not seen in the ozone data and thus needs further study.

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Fichiers liés : long-term multi-mission_vangijsel.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Philippe Jean-Pierre
• Organismes : Institut d'Administration des Entreprises - La Réunion Centre d'Économie et de Management de l'Océan Indien
• Publié dans Le Journal de l'Ile de La Réunion le 19/01/2016

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Abderrazak El AlbaniStefan BengtsonDonald E. CanfieldAndrey BekkerRoberto MacchiarelliArnaud MazurierEmma U. HammarlundPhilippe BoulvaisJean-Jacques DupuyClaude FontaineFranz T. FürsichFrançois Gauthier-LafayePhilippe JanvierEmmanuelle JavauxFrantz Ossa OssaAnne-Catherine Pierson-WickmannArmelle RiboulleauPaul SardiniDaniel VachardMartin WhitehouseAlain Meunier
• Organismes : Hydrogéologie, argiles, sols et altérations [UMR 6269] Department of Palaeozoology, Swedish Museumof Natural History, Box 50007, SE- Nordic Centre of Earth Evolution Department of Geological Sciences [Winnipeg] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] ERM Études Recherches Matériaux Stockholm University Géosciences Rennes Bureau de Recherches Géologiques et Minières Hydrogéologie, argiles, sols et altérations [UMR 6269] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Hydrogéologie, argiles, sols et altérations - FRE3114 Fachgruppe PaläoUmwelt Laboratoire d'Hydrologie et de Géochimie de Strasbourg Centre de recherche sur la Paléobiodiversité et les Paléoenvironnements Laboratoire de Paléobotanique, Paléopalynologie et Micropaléontologie Hydrogéologie, argiles, sols et altérations [UMR 6269] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Géosciences Rennes Géosystèmes - FRE 3298 Hydrogéologie, argiles, sols et altérations [UMR 6269] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Hydrogéologie, argiles, sols et altérations - FRE3114 Géosystèmes - FRE 3298 Laboratory for Isotope Geology Hydrogéologie, argiles, sols et altérations [UMR 6269] Institut de chimie des milieux et matériaux de Poitiers [UMR 7285]
• Publié dans Nature le 29/10/2020

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Résumé : The evidence for macroscopic life during the Palaeoproterozoic era (2.5-1.6Gyr ago) is controversial. Except for the nearly 2-Gyr-old coil-shaped fossil Grypania spiralis, which may have been eukaryotic, evidence for morphological and taxonomic biodiversification of macroorganisms only occurs towards the beginning of the Mesoproterozoic era (1.6-1.0Gyr). Here we report the discovery of centimetre-sized structures from the 2.1-Gyr-old black shales of the Palaeoproterozoic Francevillian B Formation in Gabon, which we interpret as highly organized and spatially discrete populations of colonial organisms. The structures are up to 12cm in size and have characteristic shapes, with a simple but distinct ground pattern of flexible sheets and, usually, a permeating radial fabric. Geochemical analyses suggest that the sediments were deposited under an oxygenated water column. Carbon and sulphur isotopic data indicate that the structures were distinct biogenic objects, fossilized by pyritization early in the formation of the rock. The growth patterns deduced from the fossil morphologies suggest that the organisms showed cell-to-cell signalling and coordinated responses, as is commonly associated with multicellular organization. The Gabon fossils, occurring after the 2.45-2.32-Gyr increase in atmospheric oxygen concentration, may be seen as ancient representatives of multicellular life, which expanded so rapidly 1.5Gyr later, in the Cambrian explosion.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Nathalie SturmMarie-Ange ThéluXavier CamousGuéorgui DimitrovMuhammad RamzanTania Dufeu-DuchesnePaula BonorinoChristiane GuillermetElisabeth BrambillaPhilippe ArversMartine PernolletVincent LeroyJean-Pierre ZarskiPatrice N MarcheEvelyne Jouvin-Marche
• Organismes : Institut d'oncologie/développement Albert Bonniot de Grenoble Département d'anatomie et cythologie pathologique Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Département d'anatomie et cythologie pathologique Institut d'oncologie/développement Albert Bonniot de Grenoble Centre de Recherches du Service de Santé des Armées Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble Institut d'oncologie/développement Albert Bonniot de Grenoble
• Publié dans Journal of Hepatology le 23/10/2020

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Résumé : BACKGROUND & AIMS: In chronic hepatitis C (CHC), HCV-specific T-cell responses are often dysfunctionnal. In vitro data point out that regulatory T cells (Treg) are able to suppress HCV-specific lymphocyte proliferation and cytokine secretion but their implication in this pathology is still debated. METHODS: Three complementary approaches were performed to investigate phenotype, frequency or localization of intra-hepatic Treg in treatment naïve CHC patients. Double immunohistochemical analysis was performed in 20 formalin-fixed biopsies with CD8/FoxP3 and CD4/FoxP3 antibodies. Cellular markers and cytokines were investigated by quantitative RT-PCR in 27 additional frozen biopsies. Eight other fresh liver biopsies were selected for complementary analysis of immunophenotyping and frequency of intra-hepatic Treg. RESULTS: Immunohistochemical analyses showed the presence of intra-hepatic CD4(+)FoxP3(+)T cells while CD8(+)FoxP3(+)T cells were very scarce. CD4(+)FoxP3(+)T cells were located in necro-inflammatory areas in contact with CD8(+)T cells, suggesting that Treg-mediated inhibition of CD8(+)T cell proliferation may occur by cell-cell contact. RT-PCR analyses showed strong correlations between CD8, FoxP3, and IL-10 with emergence of four distinct gene clusters, CD8-FoxP3, CD8-IL-10, TGF-beta-IL-10, and TNF-alpha-TGF-beta. No correlation was found between serum viral load and any immune markers. Interestingly, the FoxP3(+)/CD8(+) cells ratio significantly decreased in severe fibrosis (F>3) due to the dramatic decline of FoxP3 cells. CONCLUSIONS: This study provides new insights into the histological localization of Treg within HCV-infected liver, with a special accumulation of CD4(+)FoxP3(+)Treg cells in necro-inflammatory areas, in contact with CD8(+)T cells. Our results suggest a link between Treg, CD8, and IL-10 which altogether could balance immune responses against the virus to avoid immunopathogenesis.

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Fichiers liés : Sturm_et_al_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Philippe AmatWilliam PuechSébastien DruonJean-Pierre Pedeboy
• Organismes : Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier Image & Interaction Interactive Digital Humans Stratégies S.A. [Rungis]
• Publié dans Signal Processing: Image Communication le 30/10/2020

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Résumé : Data hiding has become increasingly important for many applications, like confidential transmission, video surveillance, military and medical applications. In this paper we present a new approach of 3D object data hiding without changing the position of vertices in the 3D space. The main idea of the proposed method is to find and to synchronize particular areas of the 3D objects used to embed the message. The embedding is carried out by changing the connectivity of edges in the selected areas composed of quadruples. The proposed approach of data hiding in 3D objects is based on minimum spanning tree (MST). This method is lossless in the sense that the positions of the vertices are remaining the same before and after embedding. Moreover the method is blind and does not depend of the order of the data in the files. This approach is very interesting when the 3D objects have been digitalized with high precision.

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Fichiers liés : 10_SPIC_AMAT.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Xavier FritelArnaud FauconnierGeorges BaderMichel CossonPhilippe DebodinanceXavier DeffieuxPierre DenysPhilippe DompeyreDaniel FaltinBrigitte FattonFrançois HaabJean-François HermieuxJacques KerdraonPierre MaresGeorges MellierNathalie MichelCédric NadeauGilberte RobainRenaud de TayracBernard Jacquetin
• Organismes : Service de gynécologie, obstétrique, médecine et biologie de la reproduction [CHU Poitiers] = Department of Gynecology, Obstetrics, Reproductive Medicine and Biology [Poitiers University Hospital] Service de gynécologie et obstétrique [CHI Poissy-Saint Germain] Service de gynécologie et obstétrique [CHI Poissy-Saint Germain] Service de gynécologie obstétrique Service de gynécologie obstétrique Service de gynécologie-obstétrique, médecine de la reproduction [Béclère] Service de médecine physique et de réadaptation [ CHU Raymond-Poincaré] Service de gynécologie et obstétrique [CHI Poissy-Saint Germain] Département de gynécologie-obstétrique Département de gynécologie-obstétrique Service de Gynécologie [CHU Clermont-Ferrand] CHU Tenon [AP-HP] Service d'urologie Centre mutualiste de Kerpape Service de gynécologie obstétrique Service de gynécologie obstétrique Médecine gériatrique Service de gynécologie, obstétrique, médecine et biologie de la reproduction [CHU Poitiers] = Department of Gynecology, Obstetrics, Reproductive Medicine and Biology [Poitiers University Hospital] CHU Charles Foix [AP-HP] Service de gynécologie, obstétrique, médecine et biologie de la reproduction [CHU Poitiers] = Department of Gynecology, Obstetrics, Reproductive Medicine and Biology [Poitiers University Hospital] Service de Gynécologie [CHU Clermont-Ferrand]
• Publié dans European Journal of Obstetrics & Gynecology and Reproductive Biology le 30/10/2020

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Résumé : Urinary incontinence is a frequent affliction in women and may be disabling and costly {LE1}. When consulting for urinary incontinence, it is recommended that circumstances, frequency and severity of leaks be specified {Grade B}. The cough test is recommended prior to surgery {Grade C}. Urodynamic investigations are not needed before lower urinary tract rehabilitation {Grade B}. A complete urodynamic investigation is recommended prior to surgery for urinary incontinence {Grade C}. In cases of pure stress urinary incontinence, urodynamic investigations are not essential prior to surgery provided the clinical assessment is fully comprehensive (standardised questionnaire, cough test, bladder diary, post-void residual volume) with concordant results {PC}. It is recommended to start treatment for stress incontinence with pelvic floor muscle training {Grade C}. Bladder training is recommended at first intention in cases with overactive bladder syndrome {Grade C}. For overweight patients, loss of weight improves stress incontinence {LE1}. For surgery, sub-urethral tape (retropubic or transobturator route) is the first-line recommended technique {Grade B}. Sub-urethral tape surgery involves intraoperative risks, postoperative risks and a risk of failure which must be the subject of prior information {Grade A}. Elective caesarean section and systematic episiotomy are not recommended methods of prevention for urinary incontinence {Grade B}. Pelvic floor muscle training is the treatment of first intention for pre- and postnatal urinary incontinence {Grade A}. Prior to any treatment for an elderly woman, it is recommended to screen for urinary infection using a test strip, ask for a bladder diary and measure post-void residual volume {Grade C}. It is recommended to carry out a cough test and look for occult incontinence prior to surgery for pelvic organ prolapse {Grade C}. It is recommended to carry out urodynamic investigations prior to pelvic organ prolapse surgery when there are urinary symptoms or occult urinary incontinence {Grade C}.

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Fichiers liés : RPC_IU_de_la_femme_recommandations_v16EJOGBR.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2010
• Auteurs : Giovanni LughezzaniPierre I. KarakiewiczPierre BigotPaul PerrotteMaxime CrépelNathalie Rioux-LeclercqVéronique Catros-QuemenerJean-Philippe MoulinouxFrançoise BouetBernard CipollaJean Jacques Patard
• Organismes : Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcome Unit Service d'urologie [Rennes] = Urology [Rennes] Service d'urologie Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Service d'urologie [Rennes] = Urology [Rennes] Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Centre Hospitalier Privé Saint-Grégoire Service d'urologie [Rennes] = Urology [Rennes]
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : INTRODUCTION: Polyamines, spermine and spermidine, are ubiquitous polycationic structures, which are essential for cell proliferation and differentiation. We tested whether spermine and spermidine could improve the prognostic ability of six established preoperative predictors of cancer-specific mortality (CSM) after partial or radical nephrectomy for renal cell carcinoma (RCC). MATERIALS AND METHODS: Overall, 385 patients with clinical stages T(1-3), M(0-1) RCC were treated with radical or partial nephrectomy at a single institution between 1990 and 2007. Kaplan-Meier plots depicted CSM after stratification according to spermine and spermidine levels (dichotomised to above and below the median value). Univariable and multivariable Cox regression models tested the prognostic ability of continuously coded spermine and spermidine levels in preoperative CSM predictions. Covariates consisted of pre-treatment T stage, M stage, age, gender and symptom classification. RESULTS: The 5-year CSM-free survival of patients with spermine levels < or =4.5 and >4.5 nmol/8x10(9) erythrocytes were, respectively, 79.5% and 65.0%. Similarly, the 5-year CSM-free survival of patients with spermidine levels < or =9.0 and >9.0 nmol/8x10(9) erythrocytes were, respectively, 81.1% and 63.7%. In multivariable analyses addressing CSM after surgery, both spermine (p< or =0.002) and spermidine (p< or =0.001) achieved independent predictor status and improved the accuracy of established preoperative CSM predictors by 2.1% (p<0.001). CONCLUSIONS: Circulating polyamine levels may significantly improve the prognostic value of established determinants of CSM in patients with RCC of all stages prior to nephrectomy. External validation of our findings is required prior to implementation in clinical practice.

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