Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2010
• Auteurs : Xiaobin YinJacqueline BoutinPaul SpurgeonJean-Luc VergelyPhilippe Waldteufel
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques ARGANS Limited Analytic and Computational Research, Inc. - Earth Sciences ESTER - LATMOS

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Résumé : SMOS (Soil Moisture and Ocean Salinity) is the first interferometric radiometer in orbit. In the first ground processing (Level 1), an image reconstruction algorithm is applied which yields measured brightness temperatures (TB). Preliminary studies have shown that this processing is critical and likely to introduce biases that affect subsequent processing. Therefore, a comparison of modelled to reconstructed TB is essential. Homogenous ocean surfaces far from land masses are ideal for this task as the TB variation with the satellite geometry (incidence angle) is relatively well known. Extensive comparisons were conducted between SMOS Level 1c TB and TB simulated using the default forward model implemented in the ESA SMOS ocean salinity processing and using ECMWF (European Centre for Medium-Range Weather Forecast) forcings. They demonstrate that the North-South behavior of SMOS measurements over the ocean is amazingly consistent with the simulated L-band signal, that the noise of the measurements with respect to the model estimate depends on the measurement location in the field of view and is very close to the expected radiometric uncertainty. On another hand, systematic biases of several Kelvins are observed, that depend on the location of the measurement in the Field of View. After these systematic biases are removed, SMOS sea surface salinity (SSS) are retrieved over 5 days in March 2010 at global scale. They match quite well the SSS climatology; SMOS anomalies with respect to the climatology are finally compared to the ones deduced from in situ measurements

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Fichiers liés : Yin_First_ESA.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Florentina RafaelDismand Stephan HouinatoPhilippe NubukpoCatherine-Marie DubreuilDuc Si TranPeter OdermattJean-Pierre ClémentMitchell G WeissPierre-Marie Preux
• Organismes : Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Unité d'Enseignement et de Recherche de Neurologie Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Hôpital Psychiatrique La Valette Neuroépidémiologie Tropicale et Comparée Service Universitaire de la Formation Permanente Neuroépidémiologie Tropicale et Comparée Swiss Tropical and Public Health Institute [Basel] Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale
• Publié dans Epilepsia le 22/10/2020

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Résumé : PURPOSE: Stigma is a major burden of epilepsy. In sub-Saharan Africa the few studies that addressed epilepsy stigma emphasize enacted, rather than perceived, stigma. This inattention may compromise clinical management and delay help seeking, thereby contributing to the treatment gap. We assessed perceived stigma and identified sociocultural and psychological factors explaining greater stigma among people with epilepsy (PWE) in Benin. METHODS: PWE included in this study were ascertained using a door-to-door survey in the general population in a Beninese rural area. We applied both qualitative and quantitative research methods to assess stigma and patient's experience and beliefs. An Explanatory Model Interview Catalogue (EMIC) and verbally administered questionnaires provided data for demographic, clinical, and sociocultural features. Sociocultural features were evaluated in terms of illness-related experience and sociocultural representations of epilepsy. Depression and anxiety were also screened. RESULTS: Eighty PWE were included. About 68.7% reported feeling stigmatized. Multivariate regression revealed that factors independently associated with perceived stigma were experience of social isolation (p < 0.001), experience of marital problems (p < 0.01), and presence of anxiety disorder (p < 0.01). DISCUSSION: Perceived stigma is an important issue in epilepsy in Benin. Social factors seem to be more influential than sociocultural representation of epilepsy. Insofar as research is needed in other African countries to determine the nature and relevant features of stigma to improve treatment and control.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Bénédicte PigneurPhilippe SeksikSheila ViolaJérôme VialaLaurent BeaugerieJean-Philippe GirardetFrank M RuemmeleJacques Cosnes
• Organismes : Université Pierre et Marie Curie - Paris 6 Université Pierre et Marie Curie - Paris 6 CHU Saint-Antoine [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Saint-Antoine [AP-HP] Université Pierre et Marie Curie - Paris 6 Service de Gastro-Entérologie et Nutrition
• Publié dans Inflammatory Bowel Diseases le 27/10/2020

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Résumé : BACKGROUND: Childhood-onset Crohn's disease (CD) might reflect a more severe form of disease. To test this hypothesis we analyzed the long-term natural history of CD in an adult cohort of patients with childhood-onset compared to adult-onset CD. METHODS: We selected 206 childhood-onset CD patients among 2992 adult patients with a diagnosis of CD established before December 31, 2000. Disease characteristics were prospectively assessed during follow-up until December 2007 and compared to adult-onset CD patients matched 2 to 1 on gender, year of CD diagnosis, and disease location. RESULTS: Compared to adult-onset CD, patients with childhood-onset CD were more likely to have a severe disease, with an increased year-by-year disease activity index (37% of patient-years in childhood-onset group versus 31% in the adult-onset group, P < 0.001). Immunosuppressant requirement was also increased with a 10-year cumulative risk of 54 +/- 3% in childhood-onset CD group versus 45 +/- 2%, in the adult-onset CD group (P < 0.001). Cumulative risks of stricturing and penetrating complications and surgical resections were not statistically different between groups. Accordingly, these events occurred at a younger age in the childhood-onset CD group. At the age of 30 years the actuarial risk of having undergone an extensive intestinal resection was 48 +/- 5% in the childhood-onset group versus 14 +/- 2% in the adult-onset group (P < 0.001). CONCLUSIONS: Patients with childhood-onset CD exhibit a more active disease and require more immunosuppressive therapy. This feature is observed irrespective of the disease location, suggesting an intrinsic more severe phenotype.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Youri RothfussPhilippe BironIsabelle BraudLaurent CanaleJean-Louis DurandJean-Paul GaudetPatricia RichardMichel VauclinThierry Bariac
• Organismes : Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Hydrologie-Hydraulique Biogéochimie et écologie des milieux continentaux Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Transpore Biogéochimie et écologie des milieux continentaux Laboratoire d'étude des transferts en hydrologie et environnement Biogéochimie et écologie des milieux continentaux
• Publié dans Hydrological Processes le 23/10/2020

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Résumé : In this study, we performed a partitioning of evapotranspiration (ET) under fully controlled conditions (climatic chamber) along growth of a tall fescue cover (Festuca arundinacea) into soil evaporation (Ev) and plant transpiration (Tr) by measuring their stable oxygen isotopic compositions (δET, δEv and δTr). We showed that it was possible, under the chamber's particular conditions, to realize the partition without (1) making the hypothesis of steady state transpiration usually done in the field, nor (2) calculating δEv as a function of air relative humidity, soil water and atmospheric vapour isotopic compositions. The contribution of Ev to total ET decreased over the experiment from 100% (bare soil) to 94% [16 days after the seeding (DAS), 83% (28 DAS), 70% (36 DAS) and 5% (43 DAS)]. Soil isotopic profiles calculated using a typical exponential-type expression and measured Ev flux were compared with the bare soil steady state measured profiles. Agreement between modelled and measured values was sensitive to soil tortuosity and kinetic fractionation values. Another significant result was highly enriched isotopic values estimated for soil water at the evaporation front [the surface under our experimental conditions (δsurf)]. The theoretical estimate of δsurf was about 1-6‰ enriched as compared to the values measured in the top 1 cm of the soil, raising important implications for the determination of δEv as a function of δsurf under field conditions. Our work also points out uncertainties related to the determination of partition values and isotopic composition measured in the field, a point that is often ignored in many papers on isotopic biogeochemistry applied to geochemical fluxes, although it can be important. Copyright © 2010 John Wiley & Sons, Ltd.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Sébastien PrevostSébastien GauthierMaria Cristina Caño de AndradeCéline MordantAli Rhida TouatiPhilippe LesotPhilippe SavignacTahar AyadPhannarath PhansavathVirginie Ratovelomanana-VidalJean-Pierre Genet
• Organismes : Laboratoire Charles Friedel Institut des Sciences Chimiques de Rennes Institut de Chimie Moléculaire et des Matériaux d'Orsay Laboratoire Hétéroéléments et Coordination Synthèses sélective organique et produits naturels Synthèses sélective organique et produits naturels Synthèses sélective organique et produits naturels Synthèses sélective organique et produits naturels
• Publié dans Tetrahedron: Asymmetry le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Jean-Baptiste WoillardJean-Philippe RerolleNicolas PicardAnnick RousseauMireille DrouetEliza MunteanuMarie EssigPierre MarquetYannick Lemeur
• Organismes : Pharmacologie des Immunosuppresseurs et de la Transplantation Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service d'Immunologie et immunogénétique [CHU Limoges] Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges] Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie
• Publié dans British Journal of Clinical Pharmacology le 29/10/2020

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Résumé : AIM: In renal transplant patients given mycophenolate mofetil (MMF), we investigated the relationship between the digestive adverse events and polymorphisms in the UGT genes involved in mycophenolic acid (MPA) intestinal metabolism and biliary excretion of its phase II metabolites. METHODS: Clinical data and DNA from 256 patients transplanted between 1996 and 2006 and given MMF with cyclosporin (CsA, n = 185), tacrolimus (TAC, n = 49) or sirolimus (SIR, n = 22), were retrospectively analysed. The relationships between diarrhoea and polymorphisms in UGT1A8 (2; 518C>G, 3; 830G>A), UGT1A7 (622C>T), UGT1A9 (-275T>A), UGT2B7 (-840G>A) and ABCC2 (-24C>T, 3972C>T) or the co-administered immunosuppressant were investigated using the Cox proportional hazard model. RESULTS: Multivariate analysis showed that patients on TAC or SIR had a 2.8 higher risk of diarrhoea than patients on CsA (HR = 2.809; 95%CI (1.730, 4.545); P < 0.0001) and that non-carriers of the UGT1A8 2 allele (CC518 genotype) had a higher risk of diarrhoea than carriers (C518G and 518GG genotypes) (HR = 1.876; 95%CI (1.109, 3.175); P = 0.0192). When patients were divided according to the immunosuppressive co-treatment, a significant effect of UGT1A8 2 was found in those co-treated with CsA (HR = 2.414; 95%CI (1.089, 5.354); P = 0.0301) but not TAC or SIR (P = 0.4331). CONCLUSION: These results suggest that a possible inhibition of biliary excretion of MPA metabolites by CsA and a decreased intestinal production of these metabolites in UGT1A8 2 carriers may be protective factors against MMF-induced diarrhoea.

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Fichiers liés : Woillard_et_al_manuscript_BJCP.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/06/2010
• Auteurs : Vincent GenotChristian JacqueyE. BudnikM. BouchemitMichel GangloffAnna A. FedorovaB. LavraudNicolas AndréG. FruitPhilippe LouarnC. HarveyE. PallierE. PenouR. HitierBaptiste CecconiF. DériotD. HeuletJean-Louis PinçonB. BessonMohammad Heydari-MalayeriDavoud-Reza SamadiDavid Valls-Gabaud
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Olivier GibertAndres GiraldoJosé-Ricardo Uclés-SantosTeresa SánchezAlejandro FernándezPhilippe P. BohuonMax ReynesAlonso GonzálezJean-Pierre PainDominique Dufour
• Organismes : Institut Agro Montpellier Démarche intégrée pour l'obtention d'aliments de qualité
• Publié dans Journal of Food Engineering le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Anne MorvanBrigitte de KorvinCatherine BourielAndré CarsinPatrick TasClaude BendavidPierre-François DupréPierre KerbratHabiba MesbahPhilippe PoreeJean Levêque
• Organismes : Service de radiologie [Vannes] Département d'imagerie Département d'imagerie Département d'imagerie Anatomopathologie Département de chirurgie Département de Chirurgie gynécologique Département d'oncologie médicale Département d'informatique médicale Département d'informatique médicale Département de chirurgie
• Publié dans Journal de Radiologie le 25/10/2020

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Résumé : PURPOSE: This study aims to evaluate the sensibility and specificity of MRI in the detection and size measuring of residual breast cancer in patients treated with neoadjuvant chemotherapy before surgery. PATIENTS AND METHODS: This is a retrospective study of 32 women, who underwent breast MRI before and after neoadjuvant treatment. MRI has been confronted to surgical pathology results. RESULTS: The sensibility of MRI to assess pathologic Complete Response (no invasive residual tumor) was excellent (100%) but the specificity was low (55,5%). There was no false negative case and four false positive cases (Two ductal carcinomas in situ and two scars-like fibrosis). When MRI outcomes were compared with the presence or absence of invasive or in situ residual carcinoma, only one false negative case was noticed (one "in situ" residual tumor). The correlation between tumor size measured by MRI and histopathology was low (r=0,32). Underestimations of tumor size were due to non-continuous tumor regression or invasive lobular carcinoma or association of invasive carcinoma and intra ductal breast cancer. Over estimations of tumor size were due to chemotherapy-induced changes. CONCLUSION: MRI is a sensitive but poorly specific method to assess the pathological complete response after neoadjuvant chemotherapy. Estimation of tumor size and detection of isolated residual in situ carcinoma are fare. Therefore, surgical intervention remains necessary whatever the MRI outcomes.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2010
• Auteurs : Véronique FressartGuillaume DuthoitErwan DonalVincent ProbstJean-Claude DeharoPhilippe ChevalierDidier KlugOlivier DubourgEtienne DelacretazPierre CosnayPatrice ScanuFabrice ExtramianaDagmar KellerFrançoise Hidden-LucetFrançoise SimonVanessa BessirardNathalie Roux-BuissonJean-Louis HebertArshid AzarineDaniele Casset-SenonFrançois RouzetYves LecarpentierGuy FontaineCatherine CoiraultRobert FrankBernard HainquePhilippe Charron
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Laboratoire Traitement du Signal et de l'Image Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Service de cardiologie Service de cardiologie Service de Cardiologie A Hôpital Ambroise Paré [AP-HP] Service de Cardiologie Centre Hospitalier Régional Universitaire de Tours Service de cardiologie et de pathologie vasculaire [CHU Caen] Service de Cardiologie Service de Cardiologie CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Laboratoire de biochimie et génétique moléculaire Service d'Explorations Fonctionnelles Cardio-Respiratoires Département de Radiologie Cardiovasculaire Service de Médecine Nucléaire [Tours] Service de Médecine Nucléaire [Paris 18eme] Service d'Explorations Fonctionnelles Cardio-Respiratoires CHU Pitié-Salpêtrière [AP-HP] Thérapie des maladies du muscle strié CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans EP-Europace le 30/10/2020

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Résumé : AIMS: Five desmosomal genes have been recently implicated in arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) but the clinical impact of genetics remains poorly understood. We wanted to address the potential impact of genotyping. METHODS AND RESULTS: Direct sequencing of the five genes (JUP, DSP, PKP2, DSG2, and DSC2) was performed in 135 unrelated patients with ARVD/C. We identified 41 different disease-causing mutations, including 28 novel ones, in 62 patients (46%). In addition, a genetic variant of unknown significance was identified in nine additional patients (7%). Distribution of genes was 31% (PKP2), 10% (DSG2), 4.5% (DSP), 1.5% (DSC2), and 0% (JUP). The presence of desmosomal mutations was not associated with familial context but was associated with young age, symptoms, electrical substrate, and extensive structural damage. When compared with other genes, DSG2 mutations were associated with more frequent left ventricular involvement (P = 0.006). Finally, complex genetic status with multiple mutations was identified in 4% of patients and was associated with more frequent sudden death (P = 0.047). CONCLUSION: This study supports the use of genetic testing as a new diagnostic tool in ARVC/D and also suggests a prognostic impact, as the severity of the disease appears different according to the underlying gene or the presence of multiple mutations.

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Fichiers liés : Fressart_2010.pdf

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