Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 17/04/2024
• Auteurs : Paul GougisAnne-Sophie HamyFloriane JochumKevin BihanMarie CarbonnelJoe-Elie SalemElise DumasRayan KabirianBeatriz GrandalSolenn BarraudFlorence CoussyJudicael HottonRaphaelle SavarinoAurélien MarabelleJacques CadranelJean-Philippe SpanoEnora LaasFabien ReyalBaptiste Abbar
• Organismes : Immunité et cancer CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Immunité et cancer Institut Curie [Paris] Immunité et cancer CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses Hôpital Foch [Suresnes] CHU Pitié-Salpêtrière [AP-HP] Immunité et cancer Immunité et cancer Immunité et cancer Immunité et cancer Immunité et cancer Institut Curie [Paris] Institut Jean Godinot [Reims] Institut Curie [Paris] Département d’Innovation Thérapeutique et essais précoces [Gustave Roussy] Immunologie anti-tumorale et immunothérapie des cancers Institut Universitaire de Cancérologie [Sorbonne Université] Institut Pierre Louis d'Epidémiologie et de Santé Publique Immunité et cancer Institut Curie [Paris] Immunité et cancer Institut Jean Godinot [Reims] Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre d'Immunologie et des Maladies Infectieuses
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : Importance With the widespread use of immune checkpoint inhibitors (ICIs), concerns about their pregnancy outcomes through maternal exposure have emerged, and clinical comparative data are lacking. Objective To assess the risk of pregnancy-, fetal-, and/or newborn-related adverse outcomes associated with exposure to ICIs compared with exposure to other anticancer agents. Design, Setting, and Participants In this cohort study, all reports mentioning a pregnancy-related condition and an antineoplastic agent (Anatomical Therapeutic Chemical classification group L01) used for a cancer indication registered in the World Health Organization international pharmacovigilance database VigiBase up to June 26, 2022, were extracted. Exposure Anticancer agents, including ICIs, used during pregnancy for a cancer indication. Immune checkpoint inhibitors included blockers of programmed cell death 1 (PD1) or its ligand (PD-L1) or cytotoxic T-lymphocyte–associated protein 4 (CTLA4). Main Outcomes and Measures The main outcome was the reporting odds ratio (ROR) for maternal, fetal, or newborn complications in patients treated with ICIs vs any other anticancer drug. Adverse events, categorized into 45 individual maternofetal adverse outcomes, were directly mapped to Medical Dictionary for Regulatory Activities preferred terms in VigiBase. Results A total of 3558 reports (ICI: 91 [2.6%]; other anticancer drugs: 3467 [97.4%]) were included in the analysis. In the ICI group, most reports were from the US (60 [65.9%]), and the mean (SD) patient age was 28.9 (10.2) years; in 24 of 55 reports with data on cancer type (43.6%), patients were treated for melanoma. The molecules involved in the ICI group were anti-PD1 (58 reports [63.7%]), anti-PD1 plus anti-CTLA4 (15 [16.5%]), anti-CTLA4 (13 [14.3%]), anti–PD-L1 (4 [4.4%]), and anti-PD1 plus anti–lymphocyte activation gene 3 (1 [1.1%]). An ICI was used in combination with a non-ICI anticancer agent in 10 participants (11.0%). Compared with other anticancer drugs, none of the 45 adverse outcomes identified were overreported in the group exposed to ICIs. However, preterm birth was significantly overreported for the anti-PD1 plus anti-CTLA4 combination compared with other anticancer drugs (12 of 15 [80.0%] vs 793 of 3452 [23.0%]; ROR, 13.87; 95% CI, 3.90-49.28; P < .001) but not for anti–PD-L1 or anti-CTLA4 monotherapy. Three reports of possibly immune-related maternofetal events were identified: 1 case of maternal antiphospholipid syndrome leading to spontaneous abortion, 1 case of pneumonitis leading to neonatal respiratory distress syndrome and death, and 1 case of transient congenital hypothyroidism. Conclusions and Relevance In this cohort study of 91 individuals exposed to ICIs during pregnancy, ICI exposure was not associated with overreporting of specific adverse pregnancy, fetal, and/or newborn outcomes compared with other anticancer treatments. However, due to possible rare immune-related neonatal adverse events, ICI use in pregnant women should be avoided when possible, especially the anti-PD1 plus anti-CTLA4 combination.

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Fichiers liés : gougis_2024_oi_240224_1712767387.39005.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/04/2024
• Auteurs : Tristan CaroffPierre GasnierMaxime GallardoJérôme BoutetRomain BaillySébastien BrulaisAudrey VidalPrince Ramahefa-AndryXavier Roussin-BouchardGaël ParentJean-Philippe GrosSébastien Boisseau
• Organismes : Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information SERMA INGENIERIE Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information ROSSIGNOL GROUP, Saint-Jean-de-Moirans, France Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Département Systèmes Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information ROSSIGNOL GROUP, Saint-Jean-de-Moirans, France Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

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Résumé : The integration of digital technologies in sports assets is unlocking novel possibilities for managing sports facilities and enhancing learning support. This paper introduces the development of an innovative batteryless sensor system, the Autonomous Ski Deflection Sensor (ASDS), designed to monitor ski wear and assess skier performance. This new system is based on a piezoelectric energy harvester that uses the energy from the ski’s deformation and vibrations to power the electronics, avoiding the use of batteries. It integrates minimalist electronics to perform measurements of the ski solicitations in turns (directly correlated to the energy harvested), store the data in memory and send them in real time to a smartphone via Bluetooth Low Energy. The ski level of the user is evaluated thanks to data fusion between the measurements from ASDS and the inertial measurement unit (IMU) of a smartphone. For this purpose, 14 measurement campaigns (200 downhill runs) were carried out to generate the database for the machine learning algorithms for ski level classification. A public experimentation phase has been scheduled during the 2023 FIS Alpine World Ski Championships, proposing 40 pairs of skis equipped with TRL7 ASDS prototypes to participants. This initiative has allowed the evaluation of the system’s reliability, and demonstrated its potential benefits for diverse range of endusers within the skiing community. This ASDS system has the potential to enhance the skiing experience for users by providing insights to improve safety, performance, and enjoyment on the slopes. Alternatively, based on the monitoring of the ski usage/health, such system could promote new services and business models based on circular economy principles.

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Fichiers liés : CAROFF_SSI2024_final_Rev2.pdf SSI 2024 SMARTSKI_EN.pdf

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• Type de publi. : Rapport
• Date de publi. : 16/04/2024
• Auteurs : Jean-Claude GregoireMartin GodefroidHervé JactelRaphaëlle MouttetCecile RobinAlain RoquesThomas Le BourgeoisThierry CandresseLucia GuerinNicolas DesneuxSandrine EveillardFlorence FontainePascal GentitPhilippe Castagnone-SerenoBruno HostachyEleni KazakouChristophe Le MayEric LombaertDavid MakowskiCharles ManceauArnaud MontyMaria Navajas NavarroAurélien SalleFrédéric SuffertStéphan SteyerPierre-Yves TeycheneyEric VerdinFrançois VerheggenEmmanuel GachetXavier Tassus
• Organismes : Université libre de Bruxelles Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Biodiversité, Gènes & Communautés Unité entomologie et plantes invasives Biodiversité, Gènes & Communautés Zoologie forestière Botanique et Modélisation de l'Architecture des Plantes et des Végétations Département Systèmes Biologiques Biologie du fruit et pathologie Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine Institut Sophia Agrobiotech Biologie du fruit et pathologie Université de Reims Champagne-Ardenne Laboratoire de la santé des végétaux Institut Sophia Agrobiotech Institut Agro - Montpellier SupAgro Institut Agro Rennes Angers Institut de Génétique, Environnement et Protection des Plantes Institut Sophia Agrobiotech Mathématiques et Informatique Appliquées Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Centre de Biologie pour la Gestion des Populations Université d'Orléans BIOlogie et GEstion des Risques en agriculture Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Centre wallon de Recherches Agronomiques [Belgique] = Walloon Agricultural Research Centre [Belgium] Centre de Coopération Internationale en Recherche Agronomique pour le Développement Unité de Pathologie Végétale Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire de la santé des végétaux Laboratoire de la santé des végétaux

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Résumé : Dans le cadre de la surveillance des organismes réglementés ou émergents (SORE), un dispositif de piégeage a été déployé par la DGAL1 en 2021 avec l’appui de l’INRAE et de l’ONF2. L’objectif de ce dispositif est d’effectuer une surveillance passive dans les sites d’entrée potentiels (ports, aéroports, marché d’intérêt national (MIN)) des organismes réglementés ou émergents (SORE). Ce piégeage est qualifié de « large spectre » car il peut concerner plusieurs filières de production suivies dans le cadre de la SORE (forêts, jardins et espaces verts et infrastructures (JEVI), arboriculture fruitière) en ciblant cependant majoritairement les insectes coléoptères ravageurs des ligneux. Les principes de la surveillance mise en œuvre s’appuient sur les résultats précédemment acquis dans le cadre du projet PORTRAP, utilisant des pièges génériques multi-composés pour la détection précoce d’insectes exotiques xylophages dans les sites potentiels d’entrée sur le territoire national. Les pièges ont été disposés sur 13 sites (7 ports maritimes, 1 port fluvial, 4 aéroports et 1 marché national) dispersés sur le territoire (France métropolitaine continentale). Au total 9279 individus appartenant à 110 espèces différentes ont été capturés. Aucune espèce d’insecte de quarantaine prioritaire n’a été piégée. En revanche, la présence d’individus appartenant à 8 espèces de coléoptères exotiques, a priori non présents sur notre territoire, des familles Cerambycidae et Curculionidae (sous-familles des Scolytinae et Platypodinae) a été relevée. Les 8 espèces d’insectes exotiques sont les suivantes : - Cerambycidae : Cordylomera spinicornis (Fabricius, 1775), Trichoferus campestris (Faldermann, 1835), Xylotrechus chinensis (Chevrolat, 1852), Xylotrechus stebbingi Gahan, 1906 ; - Curculionidae : Amasa sp. near truncata, Euplatypus hintzii (Schaufuss, 1897), Euplatypus parallelus (Fabricius, 1801), Xyleborus affinis Eichhoff, 1868.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/04/2024
• Auteurs : Linda HumbertEmmanuelle Proust-LemoineSylvain DubucquoiElisabeth Helen KempPascale Saugier-VeberNicole FabienIsabelle Raymond-TopCatherine Cardot-BautersJean-Claude CarelMaryse CartignyOlivier ChabrePhilippe ChansonBrigitte DelemerChristine Do CaoLaurence GuignatJean-Emmannuel KahnVeronique KerlanHervé LefebvreAgnès LinglartRoberto MalloneRachel ReynaudBoualem SendidPierre-François SouchonPhilippe TouraineJean-Louis WémeauMarie-Christine Vantyghem
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 University of Sheffield [Sheffield] Université de Rouen Normandie Hospices Civils de Lyon Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] UFR Médecine [Santé] - Université Paris Cité Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire [CHU Grenoble] Physiologie et physiopathologie endocriniennes AP-HP. Université Paris Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay AP-HP Hôpital universitaire Robert-Debré [Paris] Hôpital Claude Huriez [Lille] Hôpital Cochin [AP-HP] Lille Inflammation Research International Center - U 995 Centre Hospitalier Régional Universitaire de Brest Université de Rouen Normandie Neuroendocrine, Endocrine and Germinal Differentiation Communication Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen] Physiologie et physiopathologie endocriniennes Université Paris-Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Institut Cochin Hôpital de la Timone [CHU - APHM] Aix Marseille Université Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Hôpital universitaire Robert Debré [Reims] Sorbonne Université Centre Hospitalier Régional Universitaire [CHU Lille] Recherche translationnelle sur le diabète - U 1190
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé : Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome is a rare disease caused by biallelic mutations of the AIRE gene, usually presenting with the triad hypoparathyroidism-adrenal failure-chronic mucocutaneous candidiasis (CMC) and nonendocrine manifestations. The aim of this study was to determine the molecular profile of the AIRE gene, the prevalence of rare manifestations, and to characterize immunological disturbances in a French cohort.

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Fichiers liés : dgae211.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/04/2024
• Auteurs : Pierre GasnierMaxime GallardoRamzy RammouzNicolas GarraudLouis AraouzosAlexandra GarraudJean-Philippe Gros
• Organismes : Département Systèmes SERMA INGENIERIE Département Systèmes Département Systèmes Enerbee Technology F2A Group, F-38000 Grenoble, France Enerbee Technology F2A Group, F-38000 Grenoble, France Département Systèmes

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Résumé : In this work, we present the next generation of magnetoelectric energy harvesters developed by Enerbee Technology, and the associated power management circuit that was developed by CEA-Leti. Enerbee Technology develops a self-sufficient and connected product embedded with sensors for the regulation of indoor air quality in non-residential buildings, providing a low maintenance solution to increase the health and well-being of both the structure and the occupants, for the whole lifetime of the infrastructure. In this new generation of energy harvester, the piezoelectric part of the energy harvester has been optimized to better extract charges from the material. Therefore, a 3.4× size reduction is achieved while maintaining the same harvested energy. On the electronic side, we report a power management circuit based on a low-power implementation of a non-linear extraction technique by controlling a Flyback converter with a microcontroller unit: energy extraction occurs at the maximum voltage of the magnetoelectric harvester, allowing more power to be harvested compared to standard circuits. Compared with the standard energy harvesting interface, a power gain up to 1.75 is measured at a frequency of 47 Hz, and a Flyback efficiency up to 80% is reported for a total power of 0.5 mW.

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Fichiers liés : SSI_PowerBee _final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2024
• Auteurs : Antoine BachelardQuentin Le HingratValentine-Marie FerréMinh LêGilles PeytavinFlorence DamondCharlotte CharpentierGuillemette Fremont GoudotJeanne Goupil de BouilleSylvie LarivenPierre DelobelYazdan YazdanpanahDiane DescampsSophie MatheronJade GhosnVictor AppayBrigitte AutranAmel BesseghirSandrine Couffin-CardierguesChloé BirkléFrançoise Brun-VezinetGeneviève ChêneRémi CheynierFidéline CollinSerge EholieDidier EkouvieCatherine FaguardDelphine LebrasseurJulie LongobardiLucie MarchandMichaela Muller-TrutwinAlexandra OzanneVentzislava Petrov-SanchezCéline RoyAsier Saez-CirionFrançois SimonLinda WittkopMarie Caroline MeyohasKarine LacombeDominique SalmonAgathe RamiGilles PialouxRoland TubianaPierrre de TruchisMarie-Aude Khuong-JossesOuda DerradjiDidier TroisvalletJulie TimsitAnne-Sophie LascauxVincent JeantilsOlivier BouchaudOlivier PateyPauline Caraux-PazCécile GoujardLaurence GérardEmmanuel MortierEric FroguelYves WelkerVincent DaneluzziPhilippe GenetAnnie LeprêtreDavid ZucmanGilles ForceAnne Coutellier-SimonJean DeleuzeLaurence WeissValérie GarraitHélène Masson ColinLaurent BlumPr Jean-Daniel LelièvreAnne DulioustVéronique PerroneChristophe BillyCécile WinterIsabelle AupérinIram La TorreJean-Michel MolinaPatrick BrunetSylvia LamyAlain DevidasAmélie ChabrolElisabeth RouveixSerge KernbaumClaudine DuvivierMarie-Anne BouldouyreLoïc BodardPatrick ImbertChristophe RappFrançois BouéAgnès UludagFabrice ChaixOlivia SonOlivier BouchaudJean-Paul ViardXavier DuvalAlix Greder BelanValérie GrégoireGenviève Beck-WirthFrançois RaffiChristine DrobacheffCatherine ChirouzeThierry AllègreRenaud VerdonIsabelle Poizot-MartinCorinne DanielMoise MachadoAnne-Lise LecapitainePr Bruno MarchouLouis BernardYasmine DebabPascale LeclercqJoelle JulienJacques MoreauIsabelle RavauxCédric ArvieuxChristophe MichaudDjamila MakhloufiGwenael LemoalPhilippe ArsacThierry PrazuckAlain LafeuilladeBenoit MarthaPhilippe PerréFaiza AjanaPhilippe MorlatElisabeth BrottierMichel DuponDidier NeauJean-Luc PellegrinIsabelle RaymondNathalie MontagneThierry MayHeidi WilleYoussef DouadiJacques ReynesJean-Louis SchmitChrisitne RougerJean-Luc BergerYves PoinsignonChristiane JacometLionel PirothEric RosenthalDaniel GaripuyMartin MichaudAgnes RichéFrançois Prevoteau Du ClaryAlica NaqviJacques GaillatDavid ReyFrançois AbinoPatrick MerciéPhilippe MorlatPierre-Marie RogerEmmanuelle AïssiJean-Marie ChennebaultDominique LinéNarimamy RandrianasoloCatherine MerlePatricia GranetLaurence CaunègreLaurent CotteLaurent BoileauJean-Batiste EuzenPascale PerfezouNicolas LefebvreJean-Philippe TalarminCatherine ChirouzeSimona PavelBénédicte PonceauJulien SaisonAlbert SottoDidier LaureillardAnne VandendriesscheIuliana DarasteanuChloé BirkléSandrine Couffin-CardierguesDelphine LebrasseurLucie MarchandManal MecheriVentzislava Petrov-SanchezTounes SaidiAmi SangaréAmel BesseghirNathalie Chaghil-BoissièreGeneviève ChêneFidéline CollinValérie ConteMohamed DembeléCatherine FaguardYoussra KhalilJulie LongobardiAlexandra OzanneMaxime PallierLoretxu PinogesCéline RoyLinda WittkopSolaya ChalalLynda OualitLeia BecamSophie CirscotaCarine LascouxLydia LegerMarie LegoffIsabelle PellegrinFrançoise Brun-VezinetLeen YoussefRémi CheynierFrançoise Brun-VézinetBrigitte AutranRémi CheynierGianfranco PancinoAnne HosmalinVincent VieillardVictor AppayFrançoise Brun-VézinetAsier Saez-Cirion
• Organismes : Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Centre Hospitalier Intercommunal André Grégoire [Montreuil] AP-HP - Hôpitaux Universitaires Paris Seine-Saint-Denis Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Maladies infectieuses et tropicales [CHU Toulouse] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : Abstract We evaluated Ibalizumab (IBA)-containing standardized optimized salvage regimen (with or without a 4-week foscarnet induction) in individuals harboring multidrug-resistant human immunodeficiency virus type 2 (HIV-2). Nine were included; 2 achieved virological suppression after foscarnet induction with a sustained suppression at Week 24 after IBA initiation, and an additional individual at Week 24 after Ibalizumab initiation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/04/2024
• Auteurs : Laurence DelvilleJean-François LéonMélina MacouinYann Philippe TastevinMayoro GueyeArnaud ProiettiLaure LaffontSonia RousseMaria Dias-AlvesFrançois DemoryPierre RochettePedro Henrique da Silva ChibaneAndrea Teixera UstraLoïc. Drigo
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Géosciences Environnement Toulouse Unité Mixte Internationale "Environnement Santé Sociétés" Unité Mixte Internationale "Environnement Santé Sociétés" Centre de microcaractérisation Raimond Castaing Géosciences Environnement Toulouse Géosciences Environnement Toulouse Laboratoire d'aérologie Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Insituto de Astronomia, Geofísica e Ciências Atmosféricas, IAG-USP Insituto de Astronomia, Geofísica e Ciências Atmosféricas, IAG-USP Géosciences Environnement Toulouse

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Résumé : Atmospheric aerosols in urban areas are the result of a complex mixture of different anthropogenic sources. The chemical and granulometric profile of urban aerosols varies according to the level of economic and technological development of cities around the world. In particular, road traffic emits carbon compounds (organic and elemental) and metal oxides through combustion, braking and tyre abrasion. Our study focuses on the respective particle size distributions of the carbon and iron oxide fractions using magnetic investigations.We investigated the size distribution of anthropogenic tracers of particulate matter (PM), particulate total carbon (TC) concentration, and saturation isothermal remanent magnetization (SIRM) in two urban settings in France (Toulouse) and Senegal (Sebikotane). Using a cascade impactor, particles were segregated into 5 fractions spanning from PM10 to PM0.01. Particle mass concentration within each size range was determined via gravimetric methods, particulate carbon concentrations were assessed using thermo-optical techniques, and magnetic signals were measured through isothermal induced magnetization acquisitions.Our results showed high concentrations of particulate mass in the coarse fraction (particles larger than 1 µm). The coarse fraction showed a significantly higher magnetic signal than for finer fractions, accounting for 73% in France and 80% in Senegal of the total SIRM. In the ultrafine fraction (<0.2 µm), we noted significantly higher concentrations of TC than for other fractions, representing 41% in France and 36% in Senegal of the total particulate carbon concentration.Electron microscope observations revealed the presence of iron oxide particles in the <0.5 µm fraction however associated with a weak SIRM. Such iron particles may be produced by combustion or abrasion while we suspect that emissions by abrasion process produce larger particles.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/04/2024
• Auteurs : Annefleur LangedijkBram VranckenRobert Jan LebbinkDeidre WilkinsElizabeth KellyEugenio BaraldiAbiel Homero Mascareñas de los SantosDaria DanilenkoEun Hwa ChoiMaría Angélica PalominoHsin ChiChristian KellerRobert CohenJesse PapenburgJeffrey PernicaAnne GreenoughPeter RichmondFederico Martinón-TorresTerho HeikkinenRenato SteinMitsuaki HosoyaMarta NunesCharl VerweyAnouk EversLeyla Kragten-TabatabaieMarc A SuchardSergei Kosakovsky PondChiara PolettoVittoria ColizzaPhilippe LemeyLouis BontElena PrianteKseniya KomissarovaKi Wook YunPascale ClementMonica BauckAtul GuptaUshma WadiaIrene Rivero-CalleMagalia LumertzKoichi HasimotoShabir Madhi
• Organismes : Wilhelmina Children’s Hospital Spatial Epidemiology Lab University Medical Center [Utrecht] AstraZeneca, Gaithersburg AstraZeneca, Gaithersburg Università degli Studi di Padova = University of Padua ReSViNET Foundation Jose Eluterio Gonzalez Hospital Universitario Smorodintsev Research Institute of Influenza [Saint-Petersbourg, Russia] Seoul National University [Seoul] Universidad de Chile = University of Chile [Santiago] Shandong Agricultural University Fujian Agriculture and Forestry University Fujian Academy of Agricultural Sciences University Hospital Giessen and Marburg = Universitätsklinikum Gießen und Marburg Institut Mondor de Recherche Biomédicale Groupe de Pathologie Infectieuse Pédiatrique [Paris] Centre Hospitalier Intercommunal de Créteil Association Clinique et Thérapeutique Infantile du Val de Marne Association Française de Pédiatrie Ambulatoire McGill University = Université McGill [Montréal, Canada] McMaster University [Hamilton, Ontario] King's College Hospital Trinity College Dublin Hospital Clínico Universitario de Santiago University of Turku School of Medicine Fukushima Medical University Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Center of Excellence in Respiratory Pathogens University of the Witwatersrand [Johannesburg] University Medical Center [Utrecht] ReSViNET Foundation University of California [Los Angeles] Institute for Genomics and Evolutionary Medicine, Temple University Università degli Studi di Padova = University of Padua Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique University of Washington [Seattle] Rega Institute for Medical Research [Leuven] University Medical Center [Utrecht] Università degli Studi di Padova = University of Padua Smorodintsev Research Institute of Influenza [Saint-Petersbourg, Russia] Seoul National University [Seoul] Universidad de Chile = University of Chile [Santiago] University Hospital Giessen and Marburg = Universitätsklinikum Gießen und Marburg King‘s College London The University of Western Australia Hospital Clínico Universitario de Santiago Pontifícia Universidade Católica do Rio Grande do Sul [Brasil] = Pontifical Catholic University of Rio Grande do Sul [Brazil] = Université catholique pontificale de Rio Grande do Sul [Brésil] Fukushima Medical University School of Medicine University of the Witwatersrand [Johannesburg]
• Publié dans Nature Communications le 23/10/2020

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Résumé : Abstract Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/04/2024
• Auteurs : David R ZilkeyJean-Philippe JennyAlexandre BaudPierre FrancusDermot AntoniadesIrene Gregory-Eaves
• Organismes : McGill University = Université McGill [Montréal, Canada] Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques McGill University = Université McGill [Montréal, Canada] Institut National de la Recherche Scientifique [Québec] McGill University = Université McGill [Montréal, Canada]

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Résumé : Understanding how lake ecosystems respond to anthropogenic disturbances including mining, agriculture, deforestation, and more is often best answered with historical time series. Unfortunately, a lack of long-term monitoring data can make this difficult; paleolimnology offers an alternative, allowing for the reconstruction of past conditions using proxies from sediment records. As part of the nationally funded Canadian Lake Pulse Network, we analyzed sediment cores from 116 lakes across Canada using micro-X-ray fluorescence core-scanning (µXRF). µXRF served to generate abundance profiles for several elements (e.g., Ca, Sr, Ti, Pb, Cu, Zn), allowing for the assessment of spatiotemporal geochemical changes in Canadian lakes dating back to ~1850 AD. We calibrated µXRF core-scanning with conventional geochemical methods in a 48-lake subset and found strong correlations for numerous elements between conventional wet chemistry and µXRF-measured concentrations (Zilkey et al., accepted, Environmental Advances). We then assessed the temporal variability in sediment cores using constrained hierarchical cluster analysis and generalized additive models. Our preliminary results indicate that geochemical change demonstrates significant regional structure. On balance, lakes in eastern Canada predominantly demonstrated a temporal enrichment in metallic elements (e.g., Pb and Zn), while lakes in central and western Canada had a temporal enrichment of elements commonly associated with catchment erosion (e.g., Ti, Sr, K). Our results highlight the heterogeneity in responses across a vast landscape with diverse geological characteristics and land uses, and in the relative importance of anthropogenic disturbances shaping lake sediment geochemistry over time. Key next steps include the investigation of lakes that are distinct relative to their regional trends and the local environmental factors that might explain their contrasting response.

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Fichiers liés : EGU24-16100-print.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/04/2024
• Auteurs : Jean Baptiste BeauvalZine-Eddine KheneRazvan RahotaArnaud MejeanNicolas DoumercMorgan RoupretPhilippe PaparelArnauld VillersFranck BruyereCédric LebacleFrançois Xavier NouhaudCécile ChampyAlexandre de la TailleHervé LangJérome RizkMathieu DurandCharles DarianeThomas CharlesRomain BoissierJean Alexandre LongPierre BigotKarim BensalahJean Christophe Bernhard
• Organismes : Clinique La Croix du Sud Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Clinique La Croix du Sud CIC - HEGP Espaces et Sociétés Le Mans Université
• Publié dans World Journal of Urology le 27/10/2020

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