Philippe JEAN-PIERRE

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 08/04/2010
• Auteurs : Jean-Louis DurandThierry BariacYouri RothfussPatricia RichardPhilippe BironFrancois Gastal
• Organismes : Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères Biogéochimie et écologie des milieux continentaux Forschungszentrum Jülich GmbH | Centre de recherche de Jülich | Juelich Research Centre Laboratoire de biologie moléculaire eucaryote Biogéochimie et écologie des milieux continentaux Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/04/2010
• Auteurs : Gilles BossuetSéverine BlinMatthieu ThivetJean-Yves MarcJacques MonnierPierre MouginPierre NouvelPhilippe Barral
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Institut de recherche sur l'architecture antique Laboratoire Chrono-environnement (UMR 6249) Étude des Civilisations de l'Antiquité : de la Préhistoire à Byzance Service archéologique Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249)

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Gabriel VasileJean-Philippe OvarlezFrédéric PascalCéline Tison
• Organismes : GIPSA - Signal Images Physique ONERA - The French Aerospace Lab [Toulouse] Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) Centre National d'Études Spatiales [Toulouse]
• Publié dans IEEE Transactions on Geoscience and Remote Sensing le 31/10/2020

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Résumé : This paper presents an application of the recent advances in the field of spherically invariant random vector (SIRV) modeling for coherency matrix estimation in heterogeneous clutter. The complete description of the polarimetric synthetic aperture radar (POLSAR) data set is achieved by estimating the span and the normalized coherency independently. The normalized coherency describes the polarimetric diversity, while the span indicates the total received power. The main advantages of the proposed fixed-point (FP) estimator are that it does not require any a priori information about the probability density function of the texture (or span) and that it can directly be applied on adaptive neighborhoods. Interesting results are obtained when coupling this FP estimator with an adaptive spatial support based on the scalar span information. Based on the SIRV model, a new maximumlikelihood distance measure is introduced for unsupervised POLSAR classification. The proposed method is tested with both simulated POLSAR data and airborne POLSAR images provided by the Radar Aéroporté Multi-Spectral d'Etude des Signatures system. Results of entropy/alpha/anisotropy decomposition, followed by unsupervised classification, allow discussing the use of the normalized coherency and the span as two separate descriptors of POLSAR data sets.

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Fichiers liés : article_2008_422_R2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Fabien PifferiMélanie JouinJean-Marc AlessandriFrançoise RouxNicolas PerriereBenedicte GoustardMonique LavialleStephen C. CunnanePhilippe Guesnet
• Organismes : Mécanismes adaptatifs : des organismes aux communautés Université Paris-Saclay Neuropsychopharmacologie des addictions. Vulnérabilité et variabilité expérimentale et clinique Institut National de l'Environnement Industriel et des Risques Nutrition et Régulation Lipidique des Fonctions Cérébrales Centre de recherche du centre hospitalier de l'Université Laval Unité de recherche Nutrition et Sécurité Alimentaire
• Publié dans Neurochemistry International le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Lionel RanjardSamuel DequiedtClaudy JolivetNicolas P. A. SabyJean ThioulouseJérôme HarmandPatrice LoiselAlain RapaportSaliou FallPascal SimonetRichard JoffreNicolas Chemidlin Prévost-BouréPierre-Alain MaronChristophe MougelManuel P MartinBenoit ToutainDominique ArrouaysPhilippe Lemanceau
• Organismes : Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur InfoSol InfoSol Ecologie quantitative et évolutive des communautés [LBBE] Laboratoire de Biotechnologie de l'Environnement [Narbonne] Water Resource Modeling Water Resource Modeling Water Resource Modeling Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie Ampère, Département Bioingénierie Ampère, Département Bioingénierie Centre d’Ecologie Fonctionnelle et Evolutive Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur InfoSol InfoSol InfoSol Microbiologie du Sol et de l'Environnement FLAveur, VIsion et Comportement du consommateur
• Publié dans Agronomy for Sustainable Development le 31/10/2020

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Résumé : Microbial biogeography is the study of the distribution of microbial diversity on large scales of space and time. This science aims at understanding biodiversity regulation and its link with ecosystem biological functioning, goods and services such as maintenance of productivity, of soil and atmospheric quality, and of soil health. Although the initial concept dates from the early 20th century (Beijerinck (1913) De infusies en de ontdekking der backterien, in: Jaarboek van de Knoniklijke Akademie van Wetenschappen, Muller, Amsterdam), only recently have an increasing number of studies have investigated the biogeographical patterns of soil microbial diversity. A such delay is due to the constraints of the microbial models, the need to develop relevant molecular and bioinformatic tools to assess microbial diversity, and the non-availability of an adequate sampling strategy. Consequently, the conclusions from microbial ecology studies have rarely been generally applicable and even the fundamental power-laws differ because the taxa-area relationship and the influence of global and distal parameters on the spatial distribution of microbial communities have not been examined. In this article we define and discuss the scientific, technical and operational limits and outcomes resulting from soil microbial biogeography together with the technical and logistical feasibility. The main results are that microbial communities are not stochastically distributed on a wide scale and that biogeographical patterns are more influenced by local parameters such as soil type and land use than by distal ones, e.g. climate and geomorphology, contrary to plants and animals. We then present the European soil biological survey network, focusing on the French national initiative and the "ECOMIC-RMQS" project. The objective of the ECOMIC-RMQS project is to characterise the density and diversity of bacterial communities in all soils in the RMQS library in order to assess, for the first time, not only microbial biogeography across the whole of France but also the impact of land use on soil biodiversity (Réseau de Mesures de la Qualité des Sols = French Soil Quality Monitoring Network, 2200 soils covering all the French territory with a systematic grid of sampling). The scientific, technical and logistical outputs are examined with a view to the future prospects needed to develop this scientific domain and its applications in sustainable land use.

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Fichiers liés : hal-00886549.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Jean-Philippe BorgesRaphaël CulerrierDidier AldonAnnick BarreHervé BenoistOlivier SaurelAlain MilonAlain DidierPierre Rougé
• Organismes : Laboratoire de Recherche en Sciences Végétales
• Publié dans Protein Expression and Purification le 25/10/2020

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Résumé : The lipid transfer protein of apple fruit, Mal d 3, has been produced as a soluble recombinant protein in transformed Escherichia coli cells using the GATEWAY technology. Circular dichroism spectra showing the protein essentially consists of alpha-helices indicate that the rMal d 3 is properly folded. The (1)H NMR spectra also indicates a correct fold for the recombinant allergen. The reactivity of rMal d 3 towards IgE from apple allergic patients and in vitro degranulation activity measured on transformed rat basophil leukemia cells expressing the human Fc epsilon RI alpha-subunit of rMal d 3 is similar to those of the native allergen purified from apple fruits. The expression of active rMal d 3 in E. coli is readily feasible and offers an interesting alternative to the production of recombinant allergen in the yeast Pichia pastoris. This expression in E. coli open the way to the modification of Mal d 3 by site-directed mutagenesis for immunotherapy purposes.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Matthieu PlichartPascale Barberger-GateauChristophe TzourioPhillippe AmouyelKarine PérèsKaren RitchieXavier JouvenPierre DucimetièreJean‐philippe Empana
• Organismes : Epidémiologie cardiovasculaire et mort subite Epidémiologie et Biostatistique [Bordeaux] Neuroépidémiologie Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations Epidémiologie et Biostatistique [Bordeaux] Neuropsychiatrie : recherche épidémiologique et clinique Epidémiologie cardiovasculaire et mort subite Epidémiologie cardiovasculaire et mort subite Epidémiologie cardiovasculaire et mort subite
• Publié dans Journal of the American Geriatrics Society le 30/10/2020

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Résumé : OBJECTIVES: To prospectively assess the association between disability and incident fatal and nonfatal coronary heart disease (CHD) in older adults free of cardiovascular disease (CVD). DESIGN: A French multicenter prospective population-based cohort of 9,294 subjects, aged 65 and older at baseline, recruited between 1999 and 2001 and followed for 6 years. SETTING: Three cities in France: Bordeaux in the southwest, Dijon in the northeast, and Montpellier in the southeast. PARTICIPANTS: Seven thousand three hundred fifty-four participants with no history of CVD and with available information on disability status. Subjects were categorized at baseline as having no disability, mild disability (mobility only), and moderate or severe disability (mobility plus activities of daily living or instrumental activities of daily living). MEASUREMENTS: Incident fatal and nonfatal coronary events (angina pectoris, myocardial infarction, revascularization procedures, and CHD death). RESULTS: At baseline, the mean level of the risk factors increased gradually with the severity of disability. After a median follow-up of 5.2 years, 264 first coronary events, including 55 fatal events, occurred. After adjustment for cardiovascular risk factors, participants with moderate or severe disability had a 1.7 times (95% confidence interval (CI)=1.0-2.7) greater risk of overall CHD than nondisabled subjects, whereas those with mild disability were not at greater CHD risk. An association was also found with fatal CHD, for which the risk increased gradually with the severity of disability (hazard ratio (HR)(mild disability)=1.7, 95% CI=0.8-3.6; HR(moderate/severe disability)=3.5, 95% CI=1.3-9.3; P for trend=.01). CONCLUSION: In older community-dwelling adults, the association between disability and incident CHD is mostly due to an association with fatal CHD.

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Fichiers liés : Plichart_JAGS_58_636.pdf inserm-00617010_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Philippe ThomasCyril Hazif-ThomasM. PareaultF. ViebanJean-Pierre Clément
• Organismes : Centre de Mémoire de Ressources et de Recherches [Limoges] Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée
• Publié dans L'Encéphale le 30/10/2020

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Résumé : BACKGROUND: Estimates suggest that there are more than 700,000 adult caregivers of persons with dementia in this country, a large number of whom experience some form of sleep disturbance during the course of their caregiving career. Health care professionals are in the best position to detect and address this significant public health problem. OBJECTIVES: Prospective study of sleep with the main caregivers providing home-care for demented patients. METHODS: This study was performed on elderly persons living at home. Two populations were concerned. The control group concerned 86 old persons living in the area of Limoges (France) and was contacted to join by the senior clubs of this city. The other group concerned caregivers to persons with dementia, living with them at home, and the assessments were done during the patient assessment. Each group had a cognitive evaluation by a Folstein's test and answered a questionnaire to describe their possible sleep difficulties. RESULTS: Sixty-eight caregivers face sleep disturbance versus 25 non-caregiver controls. Caregiver sleep-problems are often linked to sleep disturbances in the care-recipient. Night-time awakenings by persons with dementia are a common precipitating cause of sleep/wake disturbances in vulnerable caregivers. Caregivers awake 2.3 times during the night versus 1.2 for control persons. Caregivers awake earlier (around 6:20) than non-caregivers (around 7:05) and their sleep time is shorter by one hour. Caregivers are more often depressed (28 in 98 versus 13 in 86) and have more often high blood pressure (56 in 98 versus 24 in 86). They received more medications and used more often self-medication. DISCUSSION: Three major contributors to caregiver sleep-disturbance are pointed in this paper: the apparition of caregiver disrupted sleep routines, caregiver burden and depression and the caregiver's physical health status. Successful treatment of a caregiver's sleep disturbance requires careful consideration of each of these contributors. Non-pharmacological options are generally recommended as a first line of treatment for managing sleep disturbances in older adults, including caregivers of persons with dementia.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Denis MullemanDelphine Chu Miow LinEmilie DucourauPatrick EmondDavid TernantCharlotte Magdelaine-BeuzelinJean-Pierre ValatGilles PaintaudPhilippe Goupille
• Organismes : Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
• Publié dans Ther. Drug Monit. le 30/11/-0001

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Résumé : Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and is approved for refractory rheumatoid arthritis. We studied the association between infliximab concentration and long-term control of disease activity in patients with rheumatoid arthritis treated on a routine basis both in cross-sectional analysis and over the long term. Trough serum infliximab concentrations were measured in patients with rheumatoid arthritis receiving infliximab infusions during the period August to October 2006. Disease activity was assessed by the Disease Activity Score for 28 Joints (DAS28) and usual biologic markers. During a 42-week follow-up period, patients were classified into two groups: those continuing with the same or lower doses of infliximab (Group A = treatment success) and those who switched to another bio-pharmaceutical or required an increase in infliximab dose (Group B = treatment failure). Treatment maintenance for Group A was analyzed by categories of infliximab concentration at baseline and compared by the log rank test. In 28 patients, C-reactive protein and infliximab concentrations were inversely related. Infliximab concentration in patients with low disease activity (DAS28 3.2 or less) was higher than in those with persistent active disease (DAS28 greater than 3.2); median values were 3.26 and 0.16 mg/L, respectively (P < 0.01). Analysis after 42 weeks showed that patients in Group A had higher infliximab concentrations at baseline than those with treatment failure (P < 0.01). In rheumatoid arthritis, infliximab concentration is predictive of sustained efficacy with the same infliximab regimen and should be considered on a routine basis.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Pablo Ortega-DeballonFrançois RadaisOlivier FacyPhilippe d'AthisDavid MassonPierre E. CharlesNicolas CheynelJean-Pierre FavrePatrick Rat
• Organismes : Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) Service Biostatistiques et Informatique Médicale (CHU de Dijon) Laboratoire de biochimie (CHU de Dijon) Service de Réanimation Médicale (CHU de Dijon) Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon) Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon)
• Publié dans World Journal of Surgery le 27/10/2020

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Résumé : BACKGROUND: Nowadays, most patients who undergo colorectal surgery are discharged early. An early predictor of septic complications could avoid readmissions and decrease morbidity. CRP could be a good predictor allowing a safe discharge. METHODS: A prospective, observational study was conducted from November 2007 to October 2008. All patients who underwent elective colorectal surgery were included. Clinical (temperature, pulse, abdominal tenderness, bowel movements) and laboratory data (C-reactive protein, leukocyte count) were recorded and evaluated as early predictors of septic complications (namely, anastomotic leaks). All detected leaks were considered fistulas, independently of their clinical significance. Clinical and inflammatory parameters were analyzed with univariate and multivariate techniques; logistic regression was performed and areas under the receiver operating characteristic curve were compared. RESULTS: A total of 133 patients were included. The overall incidence of anastomotic leaks was 15.5% and mortality was 4.5%. C-reactive protein at postoperative days 2 and 4 was a good predictor of anastomotic leak (areas under the curve were 0.715 and 0.845, respectively) and other postoperative septic complications (areas under the curve were 0.804 and 0.787), showing the highest accuracy among clinical and laboratory data. A cutoff of 125 mg/l in the level of C-reactive protein at postoperative day 4 yielded a sensitivity of 81.8% and a negative predictive value of 95.8% for the detection of anastomotic leakage. CONCLUSIONS: C-reactive protein is a simple way to ensure a safe discharge from hospital after elective colorectal surgery. Patients with CRP values >125 mg/l on the fourth postoperative day should not be discharged.

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Fichiers liés : Manuscript.pdf inserm-00475068_edited.pdf

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