Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Eloi MarijonLudovic TrinquartAkli OtmaniChristophe LeclercqLaurent FauchierPhilippe ChevalierDidier KlugPascal DefayeNicolas LelloucheJacques MansouratiJean-Claude DeharoNicolas SadoulFrédéric AnselmePhilippe MauryJean-Marc DavyFabrice ExtramianaFrançoise Hidden-LucetVincent ProbstPierre BordacharHassan MansourMichel ChauvinXavier JouvenThomas LavergneGilles ChatellierJean-Yves Le HeuzeyNon Renseigné
• Organismes : Service de cardiologie pédiatrique [CHU Necker] Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques [CHU HEGP] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Service de cardiologie Service de Cardiologie A Cardiac Stimulation and Rhythmology Service de cardiologie Optimisation des régulations physiologiques Service de cardiologie Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité Service de Cardiologie [CHRU Nancy] Service de Cardiologie [CHU Rouen] Service de Cardiologie CHU Pitié-Salpêtrière [AP-HP] ITX - unité de recherche de l'institut du thorax Centre Hospitalier Universitaire de Bordeaux Epidémiologie cardiovasculaire et mort subite Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] Centre d'Investigation Clinique
• Publié dans American Heart Journal le 26/10/2020

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Résumé : BACKGROUND: Sudden cardiac death (SCD) is the predominant cause of mortality in patients with mild heart failure (HF). This 2-year follow-up, multicenter, cohort study aimed to assess the extent to which implantable cardioverter defibrillators (ICDs), by reducing SCD, lead to predominant progressive HF death in mildly symptomatic HF patients at baseline in daily medical practice. METHODS: Between June 2001 and June 2003, 1,030 New York Heart Association II patients received an ICD in 22 French centers. Sudden cardiac death and progressive HF mortality rates were assessed using competing risk methodology, and predictors for progressive HF at baseline were tested in a multivariate regression model. RESULTS: During a mean follow-up of 22 +/- 6 months, 114 deaths occurred: 12 (10.5%) due to SCD and 52 (45.6%) due to progressive HF (24-month cause-specific mortality rates of 1.2% [95% CI 0.6-1.9] and 5.4% [95% CI 4.0-6.8], respectively). Diuretics use (hazard ratio [HR] 2.8, 95% CI 1.5-5.5, P = .002), history of atrial fibrillation (HR 2.09, 95% CI 1.2-3.65, P = .01), and low ejection fraction (HR 2.7, 95% CI 1.4-4.8, P = .0008) were independent predictors for progressive HF death, whereas beta-blocker therapy was a protector (HR 0.6, 95% CI 0.3-0.9, P = .04). Half of the patients (48%) who died from progressive HF within 2 years of ICD implant initially presented with enlarged QRS (> or =120 milliseconds). CONCLUSIONS: Because of ICD efficiency, progressive HF is the main cause of death within 2 years of implant, although these patients are only mildly symptomatic at implantation. In addition to optimal pharmacologic therapy, these results raise the question of systematically implanting ICDs with cardiac resynchronization therapy in patients with electrical asynchronism at baseline.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Frantz BouhallierNathalie AllioliFabrice LavialFrédéric ChalmelMarie-Hélène PerrardPhilippe DurandJacques SamarutBertrand PainJean-Pierre Rouault
• Organismes : Institut de Génomique Fonctionnelle de Lyon Institut de Génomique Fonctionnelle de Lyon Institut de Génomique Fonctionnelle de Lyon Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes Institut de Génomique Fonctionnelle de Lyon Institut de Génomique Fonctionnelle de Lyon Institut de Génomique Fonctionnelle de Lyon Unité Médicale d'Oncologie Moléculaire et Transfert Institut de Génomique Fonctionnelle de Lyon Génétique, Reproduction et Développement Institut de Génomique Fonctionnelle de Lyon
• Publié dans RNA le 29/10/2020

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Résumé : Spermatogenesis is a cyclic process in which diploid spermatogonia differentiate into haploid spermatozoa. This process is highly regulated, notably at the post-transcriptional level. MicroRNAs (miRNAs), single-stranded noncoding RNA molecules of about 20-25 nucleotides, are implicated in the regulation of many important biological pathways such as proliferation, apoptosis, and differentiation. We wondered whether miRNAs could play a role during spermatogenesis. The miRNA expression repertoire was tested in germ cells, and we present data showing that miR-34c was highly expressed only in these cells. Furthermore, our findings indicate that in male gonads, miR-34c expression is largely p53 independent in contrast to previous results showing a direct link in somatic cells between the miR-34 family and this tumor suppressor protein. In order to identify target genes involved in germinal lineage differentiation, we overexpressed miR-34c in HeLa cells, analyzed the transcriptome of these modified cells, and noticed a shift of the expression profile toward the germinal lineage. Recently, it has been shown that exogenous expression of Ddx4/Vasa in embryonic chicken stem cells (cESC) induces cESC reprogramming toward a germ cell fate. When we simultaneously expressed miR-34c in such cells, we could detect an up-regulation of germ cell-specific genes whereas the expression of other lineage specific markers remained unchanged. These data suggest that miR-34c could play a role by enhancing the germinal phenotype of cells already committed to this lineage.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : David TernantF. LauferonDenis MullemanD. WendlingEmilie DucourauJean-Pierre ValatPhilippe GoupilleGilles Paintaud
• Organismes : Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
• Publié dans Fundamental & Clinical Pharmacology le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2010
• Auteurs : Isabelle JéruSandrine MarlinGaëlle Le BorgneEmmanuelle CochetSylvain NormandPhilippe DuquesnoyFlorence Dastot - Le MoalLaurence CuissetVéronique HentgenTeresa Fernandes AlnemriJean-Claude LecronRobin DhoteGilles GrateauEmad AlnemriSerge Amselem
• Organismes : Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Génétique Microbienne et Environnement Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Institut Cochin Centre Hospitalier de Versailles André Mignot University of Pennsylvania [Philadelphia] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Laboratoire Inflammation, Tissus épithéliaux et Cytokines [EA 4331] Hôpital Avicenne [AP-HP] Université Paris 13 CHU Tenon [AP-HP] University of Pennsylvania [Philadelphia] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans Arthritis and Rheumatism le 27/10/2020

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Résumé : Objective: To gain insight into the pathophysiology of an atypical familial form of an autoinflammatory disorder, characterized by autosomal-dominant sensorineural hearing loss, systemic inflammation, increased secretion of interleukin-1beta (IL-1beta), and the absence of any cutaneous manifestations, and to assess the functional consequences of a missense mutation identified in the leucine-rich repeat (LRR) domain of NLRP3. Methods: Microsatellite markers were used to test the familial segregation of the NLRP3 locus with the disease phenotype. All NLRP3 exons were screened for mutations by sequencing. Functional assays were performed in HEK 293T cells to determine the effects of mutated (versus normal) NLRP3 proteins on NF-kappaB activation, caspase 1 signaling, and speck formation. Results: A heterozygous NLRP3 missense mutation (p.Tyr859Cys) was identified in exon 6, which encodes the LRR domain of the protein. This mutation was found to segregate with the disease phenotype within the family, and had a moderate activating effect on speck formation and procaspase 1 processing and did not alter the inhibitory properties of NLRP3 on NF-kappaB signaling. Conclusion: This report is the first to describe a familial form of a cryopyrinopathy associated with a mutation outside of exon 3 of NLRP3. This finding, together with the known efficacy of anti-IL-1 treatments in these disorders, underlines the importance of screening all exons of NLRP3 in patients who present with atypical manifestations. In addition, the gain of function associated with this mutation in terms of activation of caspase 1 signaling was consistent with the observed inflammatory phenotype. Therefore, this study of the functional consequences of an LRR mutation sheds new light on the clinical relevance of in vitro assays.

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• Type de publi. : Article dans une revue
• Date de publi. : 31/03/2010
• Auteurs : Florentina RafaelCatherine-Marie DubreuilAnnie Prado-JeanFrancis BurbaudJean-Pierre ClémentPierre-Marie PreuxPhilippe Nubukpo
• Organismes : Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Hôpital Psychiatrique La Valette
• Publié dans Annals of neurosciences le 21/10/2020

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Résumé : Epilepsy is often associated with discrediting representations even in the developed countries. The prevalence of disease is 3-5 in thousand. Our purpose was to assess social and cultural representation of epilepsy in the elderly in two French departments (Haute-Vienne and Creuse). An analysis of the answers given by 380 (190 in Haute-Vienne and 190 in Creuse) persons aged 65 and more, selected with the method of quota, during a face to face interview using a questionnaire which explores the representations of epilepsy. The interview was done in 2003 during the local step of an international multi centric community survey entitled "Mental disorders: Image and Realities in community sample". Beliefs in supernatural causes of epilepsy, witchcraft, curse and punishment are more important in elderly aged 65 and more prevalent compared to the younger subjects; it's the opposite for social causes (conflicts, bereavements, stress). The alimentary interdictions are also persistent. Medical assistance keep a good place in the knowledge of the therapy of epilepsy. It showed that those aged 65 and more in Haute-Vienne had social and cultural representation of epilepsy, generally more pessimistic than those of the persons aged less than 65. The study confirmed a decrease in the stigma about epilepsy. This data suggest a better consideration of the social and cultural representations in the fight against epilepsy even in western countries.

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• Type de publi. : Article dans une revue
• Date de publi. : 31/03/2010
• Auteurs : Luc DauchetMichèle MontayeJean Bernard RuidavetDominique ArveilerFrank KeeAnnie BinghamJean FerrièresBernadette HaasAlun EvansPierre DucimetièrePhillippe AmouyelJean Dallongeville
• Organismes : Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap Université Toulouse III - Paul Sabatier Altération génétique des cancers, chimioprévention et réponse thérapeutique Department of Epidemiology and Public Health Epidémiologie cardiovasculaire et mort subite Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap Université Toulouse III - Paul Sabatier Altération génétique des cancers, chimioprévention et réponse thérapeutique Department of Epidemiology and Public Health Epidémiologie, sciences sociales, santé publique Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
• Publié dans European Journal of Clinical Nutrition le 24/10/2020

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Résumé : Background. Fruit and vegetable (F&V) consumption is associated with a lower cardiovascular (CVD) risk. Smoking, in contrast, is a major CVD risk factor. Objective. To compare the relationship between the frequency of F&V intake and CVD risk in current, former and never smoker men. Design. The PRIME study is a prospective study in men (n=8060), aged 50-59 years, free of coronary heart disease or stroke at inclusion, recruited in France and Northern Ireland between 1991 and 1993. Frequency of F&V intake was assessed by a food frequency questionnaire. The outcomes are incident cases of acute coronary syndrome (ACS), and total coronary heart disease and stroke (CVD) observed over 10 years. Results. During the follow-up, a total of 367 ACS and 612 CVD events occurred. In multivariable analyses we found a statistical interaction between smoking status and frequency of F&V intake and for ACS and CVD (p< 0.05). In smokers, the relative risks for ACS was 0.78 [0.54-1.13] in the 2nd and 0.49 [0.30-0.81] in the 3rd tertile of F&V intake compared to the 1st tertile (p trend<0.001); the results for CVD were 0.80 [0.59-1.08] and 0.64 [0.44-0.93], respectively (p trend<0.001). In contrast, no statistically significant associations were observed among never and former smokers. Similar statistical interactions for ACS were observed for fruit intake (p=0.07) and vegetable (p <0.05). Conclusion. These results suggest that high F&V intake in men is associated with favourable CVD outcomes in smokers.

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Fichiers liés : PEER_stage2_10.1038%2Fejcn.2010.46.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/03/2010
• Auteurs : Marie-Béatrice Bogeat-TriboulotDavid CohenDidier Le ThiecSandrine BalzergueMartin-Magniette Marie-LaureJean-Pierre RenouPhilippe LabelMarie-Claude Lesage-DescausesFrançoise LauransIsabelle BourgaitAnnabelle DéjardinJean-Charles LepléDomenico MorabitoLudovic BonhommeFranck F. BrignolasDelphine D. VincentChristophe PlomionIrène Hummel
• Organismes : Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Unité de recherche en génomique végétale Unité de recherche en génomique végétale Unité de recherche en génomique végétale Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Arbres et Réponses aux Contraintes Hydriques et Environnementales Biodiversité, Gènes & Communautés Biodiversité, Gènes & Communautés Ecologie et Ecophysiologie Forestières [devient SILVA en 2018]

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Fichiers liés : 40769_20110405014201697_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/03/2010
• Auteurs : Samy OmriBoubaker OmriMichèle SavoldelliLaurent JonetBrigitte Thillaye-GoldenbergGilles ThuretPhilippe GainJean-Claude JeannyPatricia CrisantiFrancine Behar-Cohen
• Organismes : Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Service d’Ophtalmologie [CHU Saint-Etienne] Service d’Ophtalmologie [CHU Saint-Etienne] Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Centre de Recherche des Cordeliers Service d'ophtalmologie [Hôtel-Dieu - Paris]
• Publié dans Clinical ophthalmology le 26/10/2020

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Résumé : Purpose: The outer limiting membrane (OLM) is considered to play a role in maintaining the structure of the retina through mechanical strength. However, the observation of junction proteins located at the OLM and its barrier permeability properties may suggest that the OLM may be part of the retinal barrier. Material and methods: Normal and diabetic rat, monkey, and human retinas were used to analyze junction proteins at the OLM. Proteome analyses were performed using immunohistochemistry on sections and flat-mounted retinas and western blotting on protein extracts obtained from laser microdissection of the photoreceptor layers. Semi-thin and ultrastructure analyses were also reported. Results: In the rat retina, in the subapical region zonula occludens-1 (ZO-1), junction adhesion molecule (JAM), an atypical protein kinase C, is present and the OLM shows dense labeling of occludin, JAM, and ZO-1. The presence of occludin has been confirmed using western blot analysis of the microdissected OLM region. In diabetic rats, occludin expression is decreased and glial cells junctions are dissociated. In the monkey retina, occludin, JAM, and ZO-1 are also found in the OLM. Junction proteins have a specific distribution around cone photoreceptors and Müller glia. Ultrastructural analyses suggest that structures like tight junctions may exist between retinal glial Müller cells and photoreceptors. Conclusions: In the OLM, heterotypic junctions contain proteins from both adherent and tight junctions. Their structure suggests that tight junctions may exist in the OLM. Occludin is present in the OLM of the rat and monkey retina and it is decreased in diabetes. The OLM should be considered as part of the retinal barrier that can be disrupted in pathological conditions contributing to fluid accumulation in the macula.

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Fichiers liés : _the-outer-retinal-barriers-revisited--clinical-implications.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/03/2010
• Auteurs : Denis BarataudGuillaume NeveuxOlivier TantotCyril DecrozeDanielle RoussetLaurent HagermanPierre LabanowskiJean Pierre LainéR. FoinetVincent MergnacPhilippe Leproux
• Organismes : C2S2 C2S2 MINACOM XLIM C2S2 XLIM XLIM Université de Limoges Université de Limoges PHOTONIQUE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/03/2010
• Auteurs : Pierre-Henri BombengerJean-Philippe Waaub
• Organismes : Département d'informatique [Montréal] Groupe d'études interdisciplinaires en géographie et environnement régional

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Résumé : This paper presents the methodology developed for the experimental implementation of the Integrated Rural Planning System (IRPS) in the Regional Natural Park of Ballons des Vosges. This involves a socio-technical approach aiming at an increased inclusion of sustainable land use planning principles in local urban plans (LUP). This approach is enforced by using standard geographic information system (GIS), simulation of management scenarios and multicriteria decision aid tools. It is tested on three communities developing their LUP inside the Park.

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Fichiers liés : ITGO_2010-paper-bombenger-waub-En.pdf

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