Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Philippe CinquinChantal GondranF. GiroudSimon MazabrardAymeric PellissierFrancois BoucherJean-Pierre AlcarazKarine GorgyFrançois LenouvelStéphane MathéPaolo PorcuSerge Cosnier
• Organismes : Gestes Medico-chirurgicaux Assistés par Ordinateur Département de Chimie Moléculaire - Biosystèmes Electrochimiques et Analytiques Département de Chimie Moléculaire - Biosystèmes Electrochimiques et Analytiques Département de Chimie Moléculaire Département de Chimie Moléculaire Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 Plastes et Différenciation Cellulaire Département de Chimie Moléculaire - Biosystèmes Electrochimiques et Analytiques Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 Laboratoire d'Ingénierie des Systèmes Biologiques et des Procédés Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 Département de Chimie Moléculaire - Biosystèmes Electrochimiques et Analytiques
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Powering future generations of implanted medical devices will require cumbersome transcutaneous energy transfer or harvesting energy from the human body. No functional solution that harvests power from the body is currently available, despite attempts to use the Seebeck thermoelectric effect, vibrations or body movements. Glucose fuel cells appear more promising, since they produce electrical energy from glucose and dioxygen, two substrates present in physiological fluids. The most powerful ones, Glucose BioFuel Cells (GBFCs), are based on enzymes electrically wired by redox mediators. However, GBFCs cannot be implanted in animals, mainly because the enzymes they rely on either require low pH or are inhibited by chloride or urate anions, present in the Extra Cellular Fluid (ECF). Here we present the first functional implantable GBFC, working in the retroperitoneal space of freely moving rats. The breakthrough relies on the design of a new family of GBFCs, characterized by an innovative and simple mechanical confinement of various enzymes and redox mediators: enzymes are no longer covalently bound to the surface of the electron collectors, which enables use of a wide variety of enzymes and redox mediators, augments the quantity of active enzymes, and simplifies GBFC construction. Our most efficient GBFC was based on composite graphite discs containing glucose oxidase and ubiquinone at the anode, polyphenol oxidase (PPO) and quinone at the cathode. PPO reduces dioxygen into water, at pH 7 and in the presence of chloride ions and urates at physiological concentrations. This GBFC, with electrodes of 0.133 mL, produced a peak specific power of 24.4 microW mL(-1), which is better than pacemakers' requirements and paves the way for the development of a new generation of implantable artificial organs, covering a wide range of medical applications.

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Fichiers liés : 2010_PLoSONE_PC_.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Maëlenn GuerchetPascal M'BelessoAlain Maxime MouangaBébène Ndamba-BandzouziAndré TaboDismand Stephan HouinatoMoussiliou Noël ParaïsoPascale Cowppli-BonyPhilippe NubukpoVictor AboyansJean-Pierre ClémentJean-François DartiguesPierre-Marie Preux
• Organismes : Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Hôpital Psychiatrique La Valette Neuroépidémiologie Tropicale et Comparée Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Service de Psychiatrie [CHU Limoges] Epidémiologie et Biostatistique [Bordeaux] Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale
• Publié dans Dementia and Geriatric Cognitive Disorders le 01/11/2020

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Résumé : BACKGROUND: Data on dementia from low- and middle-income countries are still necessary to quantify the burden of this condition. This multicenter cross-sectional study aimed at estimating the prevalence of dementia in 2 large cities of Central Africa. METHODS: General population door-to-door surveys were conducted in the districts of Bangui (Republic of Central Africa) and Brazzaville (Congo) in elderly aged ≥ 65 years. The subjects were screened with the Community Screening Interview for Dementia and the Five-Words Test. Diagnosis of dementia was made according to the DSM-IV criteria and to the clinical criteria proposed by the NINCDS-ADRDA for Alzheimer's disease. RESULTS: We enrolled 496 subjects in Bangui and 520 in Brazzaville. The prevalence of dementia was estimated at 8.1% (95% CI = 5.8-10.8) in Bangui and 6.7% (95% CI = 4.7-9.2) in Brazzaville. CONCLUSION: The prevalence of dementia in urban areas of Central Africa is close to those observed in high-income countries.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Giovanna TinettiJames Y.-K. ChoCaitlin A. GriffithOlivier GrassetLee GrenfellTristan GuillotTommi T. KoskinenJulianne I. MosesDavid PinfieldJ. TennysonMarcell TessenyiRobin WordsworthAlan AylwardRoy van BoekelAngioletta CoradiniTherese EncrenazIgnas SnellenMaria R. Zapatero-OsorioJeroen BouwmanVincent Coudé Du ForestoMercedes Lopez-MoralesIngo Mueller-WodargEnric PalléFranck SelsisAlessandro SozzettiJean-Philippe BeaulieuThomas HenningMichael MeyerGiuseppina MicelaIgnasi RibasDaphne StamMark G. SwainOliver KrauseMarc OllivierEmanuele PaceBruce SwinyardPeter A. R. AdeNick AchilleosAlberto AdrianiCraig B. AgnorCristina AfonsoCarlos Allende PrietoGaspar BakosRobert J. BarberMichael BarlowPeter BernathBruno BézardPascal BordéLinda R. BrownArnaud CassanCéline CavarrocAngela CiaravellaCharles CockellAthena CoustenisCamilla DanielskiLeen DecinRemco de KokO. DemangeonPieter DerooPeter DoelPierre DrossartLeigh N. FletcherMatteo FocardiFrançois ForgetSteve FosseyPascal FouquéJames FrithMarina GalandPatrick GaulmeJonay I. González HernándezDavide GrassiMatt J. GriffinUlrich GrözingerManuel GüdelPactrick GuioOlivier HainautRobert HargreavesPeter H. HauschildtKevin HengDavid HeyrovskyRicardo HuesoPat IrwinLisa KalteneggerPatrick KervellaDavid KippingGeza KovacsAntonino La BarberaHelmut LammerEmmanuel LellouchGiuseppe LetoMercedes Lopez MoralesMiguel A. Lopez ValverdeManuel Lopez-PuertasChristophe LoviAntonio MaggioJean-Pierre MaillardJesus Maldonado PradoJean-Baptiste MarquetteFrancisco J. Martin-TorresPierre MaxtedSteve MillerSergio MolinariDavid MontesAmaya Moro-MartínOlivier MousisNapoléon Nguyen TuongRichard P. NelsonGlenn OrtonÉric PantinEnzo PascaleStefano PezzutoEnnio PorettiRaman PrinjaLoredana PrisinzanoJean-Michel RéessAnsgar ReinersBenjamin SamuelJorge Sanz ForcadaDimitar SasselovGiorgio SaviniBruno SicardyAlan SmithLars StixrudeGiovanni StrazzullaGautam VasishtSandrine VinatierSerena VitiIngo WaldmannGlenn J. WhiteThomas WidemannRoger YelleYuk YungSergey Yurchenko
• Organismes : University College London [UCL] Lunar and Planetary Laboratory [Tucson] Laboratoire de Planétologie et Géodynamique de Nantes [UMR 6112] Laboratoire de Cosmologie, Astrophysique Stellaire & Solaire, de Planétologie et de Mécanique des Fluides Department of Physics and Astronomy [UCL London] Laboratoire de Météorologie Dynamique (UMR 8539) Istituto di Fisica dello Spazio Interplanetario Laboratoire d'études spatiales et d'instrumentation en astrophysique Département d'Astrophysique (ex SAP) Laboratoire d'Astrophysique de Bordeaux [Pessac] Observatoire aquitain des sciences de l'univers Université Sciences et Technologies - Bordeaux 1 Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux Institut d'Astrophysique de Paris Max-Planck-Institut für Astronomie Liquides Ioniques et Interfaces Chargées INAF - Osservatorio Astronomico di Palermo Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] SRON Netherlands Institute for Space Research University of Calgary Institut d'astrophysique spatiale School of Physics and Astronomy [London] Laboratoire d'études spatiales et d'instrumentation en astrophysique Laboratoire d'études spatiales et d'instrumentation en astrophysique Jet Propulsion Laboratory Institut d'Astrophysique de Paris Astronomische Rechen-Institut [Heidelberg] Laboratoire d'études spatiales et d'instrumentation en astrophysique Planetary and Space Sciences Research Institute [Milton Keynes] Laboratoire d'études spatiales et d'instrumentation en astrophysique Laboratoire d'études spatiales et d'instrumentation en astrophysique Department of Atmospheric, Oceanic and Planetary Physics [Oxford] Laboratoire de Météorologie Dynamique (UMR 8539) Institut Pierre-Simon-Laplace Laboratoire Astrophysique de Toulouse-Tarbes Blackett Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique Istituto di Fisica dello Spazio Interplanetario Escuela Superior de Ingenieria Harvard-Smithsonian Center for Astrophysics Space Research Institute of Austrian Academy of Sciences Laboratoire d'études spatiales et d'instrumentation en astrophysique INAF - Osservatorio Astronomico di Palermo Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Department of Science and Technology Studies [London] Univers, Théorie, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) Queen Mary University of London Astrophysique Interprétation Modélisation Laboratoire d'études spatiales et d'instrumentation en astrophysique Institut d'astrophysique spatiale Laboratoire d'études spatiales et d'instrumentation en astrophysique Institut universitaire de France Imperial College Healthcare NHS Trust Laboratoire d'études spatiales et d'instrumentation en astrophysique STFC Rutherford Appleton Laboratory Department of Physics and Astronomy [Milton Keynes] Laboratoire d'études spatiales et d'instrumentation en astrophysique

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Résumé : The science of extra-solar planets is one of the most rapidly changing areas of astrophysics and since 1995 the number of planets known has increased by almost two orders of magnitude. A combination of ground-based surveys and dedicated space missions has resulted in 560-plus planets being detected, and over 1200 that await confirmation. NASA's Kepler mission has opened up the possibility of discovering Earth-like planets in the habitable zone around some of the 100,000 stars it is surveying during its 3 to 4-year lifetime. The new ESA's Gaia mission is expected to discover thousands of new planets around stars within 200 parsecs of the Sun. The key challenge now is moving on from discovery, important though that remains, to characterisation: what are these planets actually like, and why are they as they are? In the past ten years, we have learned how to obtain the first spectra of exoplanets using transit transmission and emission spectroscopy. With the high stability of Spitzer, Hubble, and large ground-based telescopes the spectra of bright close-in massive planets can be obtained and species like water vapour, methane, carbon monoxide and dioxide have been detected. With transit science came the first tangible remote sensing of these planetary bodies and so one can start to extrapolate from what has been learnt from Solar System probes to what one might plan to learn about their faraway siblings. As we learn more about the atmospheres, surfaces and near-surfaces of these remote bodies, we will begin to build up a clearer picture of their construction, history and suitability for life. The Exoplanet Characterisation Observatory, EChO, will be the first dedicated mission to investigate the physics and chemistry of Exoplanetary Atmospheres. By characterising spectroscopically more bodies in different environments we will take detailed planetology out of the Solar System and into the Galaxy as a whole. EChO has now been selected by the European Space Agency to be assessed as one of four M3 mission candidates.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Jean-François CantaloubePierre GallianAmelia BokiloFrançois JordierPhilippe BiaginiHoussam AttouiChiaroni JacquesPhilippe de Micco
• Organismes : Anthropologie bio-culturelle, Droit, Ethique et Santé Anthropologie bio-culturelle, Droit, Ethique et Santé Anthropologie Bio-Culturelle CNTS of Brazzaville Anthropologie bio-culturelle, Droit, Ethique et Santé Anthropologie bio-culturelle, Droit, Ethique et Santé Institute for Animal Health Anthropologie bio-culturelle, Droit, Ethique et Santé Anthropologie bio-culturelle, Droit, Ethique et Santé
• Publié dans Journal of Medical Virology le 25/10/2020

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Résumé : The aim of this study was to assess the seroprevalence, viremia, genotype distribution, and demographic history of hepatitis C virus (HCV) in the Republic of the Congo. Testing was carried out on sera samples collected in 2005 from 807 Bantus belonging to the Kongo, Teke, and Ngala subgroups and 80 Pygmies. Positive HCV serology was found in 50 (5.6%) individuals including31 (60%) who were viremic. Seroprevalence increased with age with a cutoff at 50 years:2.8% <50 versus 12% >50. Twenty-one strains belonged to four described subtypes, that is, 4c in eight cases, 4h in two, 4k in three, and 4r in eight. Ten strains could not be assigned to any known subtype and may represent six new variants, that is, subtype 4 in five cases and subtype 2 in one. Evolutionary analysis of subtype 4c and 4r sequences indicated a period of enhanced transmission in the mid-twentieth century probably due to iatrogenic causes. This study underlines the high genetic diversity of strains in the Republic of the Congo with nine subtypes 4 and one subtype 2.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Grégory GermainPhilippe DruaultRoger LewandowskiBenoît VincentDaniel PriourJean-Yves Billard
• Organismes : Unité Essais et Recherches Technologiques Institut Jean Le Rond d'Alembert Institut de Recherche Mathématique de Rennes Cambridge Carbonates, Ltd Centre Armoricain d'Etude Structurale des Socles Institut de Recherche de l'Ecole Navale

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Résumé : The project presented here and named HydroPêche aims to develop a tool for an automatic optimisation of trawl in order to minimize the drag of the gear. For that purpose, different aspects are studied in order: a/ to extend the basis of experimental data on flow characteristics governing the hydrodynamic behaviour of different porous structures ; b/ to develop numerical tools to simulate more realistic flow around porous structures taking into account fluid / structure interactions; c/ to develop automatic optimisation tools to design efficient trawls in terms of energy consumption. The developed tool should provide a substantial gain on the fuel consumed of actual fishing devices while maintaining a comparable fishing efficiency. The developments made will also be extended to study different types of porous structures used for fishing and aquaculture devices and to better understand the development of selectivity devices. Initial results have been achieved: some specific data analysis was carried out from PIV measurements around a cod-end, FreeFem ++ has been used to simulate the flow around a specific cod-end and the first developments of an automatic optimisation tool give good numerical results in terms of energy efficiency for both bottom and pelagic trawls.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Alain HauchecorneJean-Loup BertauxFrancis DalaudierPhilippe KeckhutPerrine LemennaisSlimane BekkiMarion MarchandJean-Claude LebrunErkki KyröläJohanna TamminenViktoria F. SofievaDidier FussenF. VanhellemontOdile Fanton d'AndonGilbert BarrotLaurent BlanotThorsten FehrLidia Saavedra de Miguel
• Organismes : STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Finnish Meteorological Institute Finnish Meteorological Institute Finnish Meteorological Institute Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique Belgian Institute for Space Aeronomy / Institut d'Aéronomie Spatiale de Belgique Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences European Space Research Institute European Space Research Institute
• Publié dans Atmospheric Chemistry and Physics le 31/10/2020

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Résumé : The stellar occultation spectrometer GOMOS (Global Ozone Monitoring by Occultation of Stars) on ESA's Envisat satellite measures vertical profiles O₃, NO₂ and NO₃ with a high long-term stability due to the self-calibrating nature of the technique. More than 6 years of GOMOS data from August 2002 to end 2008 have been analysed to study the inter-annual variation of O₃, NO₂ and NO₃ in the tropics. It is shown that the QBO of the equatorial wind induces variations in the local concentration larger than 10% for O₃ and larger than 25% for NO₂. Quasi-Biennial Oscillation signals can be found in the evolution of the three constituents up to at least 45 km. We found that NO₃ is positively correlated with temperature up to 40 km in the region where it is in chemical equilibrium with O₃. Above 40 km, NO₃ is no more in equilibrium during night and its concentration is correlated with both O₃ and NO₂. For O₃ and NO₂, our results confirm the existence of a transition from a dynamical control of O₃ below 28 km with O₃ correlated with NO₂ and temperature and a chemical/temperature control between 28 and 38 km with O₃ anti-correlated with NO₂ and temperature. Above 38 km and up to 50 km a regime never described before is found with both O₃ and NO₂ anti-correlated with temperature. For the NO₂/temperature anti-correlation, our proposed explanation is the modulation of the N₂O ascent in the upper stratosphere by the QBO and the modulation of the Brewer-Dobson circulation. The oxidation of N₂O is the main source of NO_y in this altitude region. An enhancement of the ascending motion will cool adiabatically the atmosphere and will increase the amount of N₂O concentration available for NO_y formation.

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Fichiers liés : acp-10-8873-2010.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Vincent GembusSolenn JanvierJean-Pierre LecouvéPhilippe GloanecFrancis MarsaisVincent Levacher
• Organismes : Chimie Organique et Bioorganique : Réactivité et Analyse Oril Industrie Oril Industrie Institut de Recherches SERVIER Chimie Organique et Bioorganique : Réactivité et Analyse Chimie Organique et Bioorganique : Réactivité et Analyse
• Publié dans European Journal of Organic Chemistry le 22/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Norbert SchnellMarco Antonio Suarez-CifuentesJean-Philippe Lambert
• Organismes : Equipe Interactions musicales temps-réel Equipe Interactions musicales temps-réel Equipe Interactions musicales temps-réel

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Résumé : This paper describes a real-time audio analysis/resynthesis system that we developed for a music piece for ensemble and electronics. The system combines real-time audio analysis and concatenative synthesis based on the segmentation of sound streams into constituting segments and the description of segments by an efficient set of descriptors adapted to the given musical context. The system has been implemented in Max/MSP using the FTM & Co and MuBu libraries and successfully employed in the production and performance of the piece. As more and more research in the domain of music information retrieval, we use the term of typo-morhpology to designate the description of sounds by morphologic criteria including the temporal evolution of sound features that also can provide pertinent means for the classification of sounds. Although, the article mainly insists on the technical aspects of the work, it occasionally contextualizes the different technical choices regarding particular musical aspects.

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Fichiers liés : index.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2010
• Auteurs : Jean-Christophe PagèsJean-Jacques LeguayYves BertheauPascal BoireauDenis BourguetFlorence CoignardFrançois ColénoJean-Luc DarlixElie DassaMaryse DeguergueHubert De VerneuilRobert DrillienAnne Dubart-KupperchmittNicolas FerryClaudine FranchePhilippe GuercheJoël GuillemainMireille JacquemondAndré JestinBernard KlonjkowskiMarc LavielleJane LecomteOlivier Le GallStéphane LemariéDidier LereclusRémy MaximilienAntoine MesséanBertrand NeyJacques PagèsDaniel ParzyCatherine Regnault-RogerPierre RougéPatrick SaindrenanPascal SimonetVirginie TournayBernard E. VaissièreJean-Luc Vilotte
• Organismes : Institut Jean-Pierre Bourgin

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Résumé : Paris, le 14 octobre 2010 A V I S en réponse à la saisine 1 091201-saisine HCB-info compl oeillets concernant notamment le dossier C/NL/09/01. Le Haut Conseil des biotechnologies (HCB) a été saisi le 5 décembre 2009 par les autorités compétentes françaises (le Ministère de l'alimentation, de l'agriculture et de la pêche) d'une demande d'avis relative à une évaluation du dossier C/NL/09/01 de demande d'importation d'oeillets sous forme de fleurs coupées à des fins ornementales. Ce dossier a été déposé par la société Florigene Pty Limited dans le cadre de la directive 2001/18/CE auprès des autorités compétentes hollandaises, sous la référence C/NL/09/01. La saisine du HCB correspondante est référencée 091221-saisine HCB-info compl oeillets. Le Comité scientifique (CS) 2 du HCB a procédé à l'examen du dossier le 3 septembre 2010 sous la présidence de Jean-Christophe Pagès. 1 La saisine « 091221-saisine HCB-info compl oeillets » est reproduite dans l'Annexe 1. 2 La composition du CS ainsi que le rapporteur externe ayant contribué à l'élaboration de l'avis sont indiqués dans l'Annexe 2.

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Fichiers liés : 101026oeilletc-nl-09-01aviscshcb.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Stéphanie PacePhilippe GonzalezJean-Marie DevoisselleP.E. MilhietDaniel BrunelFrédérique Cunin
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Centre de Biochimie Structurale [Montpellier] Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
• Publié dans New Journal of Chemistry le 01/11/2020

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