Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Gaëlle ClainJean-Luc BarayRobert DelmasPhilippe KeckhutJ.-P. Cammas
• Organismes : Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones Laboratoire de l'Atmosphère et des Cyclones STRATO - LATMOS Laboratoire d'aérologie
• Publié dans Atmospheric Environment le 23/10/2020

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Résumé : Sixteen years of ozone measurements (1992-2006) at Reunion Island (21°S, 55.5°E) have been processed to detect stratospheric signatures on each single ozone profile. The characterisation method consists in the advection of the potential vorticity (PV) over two to ten days of backtrajectory with the lagrangian trajectory code LACYTRAJ. LACYTRAJ is a Trajectory-Reverse Domain Filling code using the ERA40 ECMWF database and allowing the reconstruction of high resolution advected PV profiles. Correlation between high values of ozone mixing ratio and high PV is interpreted as a stratospheric signature. A climatology of STE events at Reunion has been derived and reveals that STE events occur more frequently during spring (SON) and summer (DJF). The method is tested for a set of PV threshold values (i.e. 1 PVU, 1.5 PVU and 2 PVU) and for a set of duration of backtrajectories (i.e. 2 days, 5 days and 10 days). The number of detected STE is sensitive to PV threshold values and duration criterions. For instance, the number of stratospheric intrusions detected in October with a 1.5 PVU criterion ranges between 25% (2 days of backtrajectories) and 56% (10 days of backtrajectories). The vertical distributions of STE show intrusions covering the whole free troposphere (between 7 and 15 km) and mainly located in the upper troposphere. Finally, results show that an important number of stratospheric intrusions are detected during spring and in the upper troposphere what points at the contribution of the stratospheric source to the tropospheric ozone spring maximum which is strongly influenced by the biomass burning emissions from South Africa and Madagascar.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Jérôme VerineJacqueline Lehmann-CheHany SolimanJean-Paul FeugeasJean-Sébastien VidalPierre Mongiat-ArtusStéphanie BelhadjJosette PhilippeMatthieu LesageEvelyne WittmerStéphane ChanelAnne CouvelardSophie FerlicotNathalie Rioux-LeclercqJean-Michel VignaudAnne JaninStéphane Germain
• Organismes : Service d'anatomo-pathologie [Paris] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Angiogénèse embryonnaire et pathologique Pathologie et virologie moléculaire Laboratoire de biochimie Pathologie et virologie moléculaire Laboratoire de biochimie Pathologie et virologie moléculaire Laboratoire de biochimie Neuroépidémiologie Pathologie et virologie moléculaire Service d'Urologie [CHU Saint-Louis] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Angiogénèse embryonnaire et pathologique Angiogénèse embryonnaire et pathologique Laboratoire de biochimie Laboratoire Pasteur Cerba Laboratoire de Pathologie Laboratoire de Pathologie Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Service de Pathologie [CHRU Nancy] Service d'anatomo-pathologie [Paris] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Service d'anatomo-pathologie [Paris] Angiogénèse embryonnaire et pathologique
• Publié dans PLoS ONE le 25/10/2020

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Résumé : BACKGROUND: We have previously shown that angiopoietin-like 4 (angptl4) mRNA, a hypoxia-inducible gene, is highly expressed in clear cell renal-cell carcinoma (ccRCC), the most common subtype of RCC for which no specific marker is available. We here investigated whether angptl4 mRNA 1) could be a useful diagnostic and/or prognostic marker of ccRCC in a large and comprehensive retrospective series, 2) induction is dependent on the VHL status of tumors. METHODOLOGY/PRINCIPAL FINDINGS: Using in situ hybridization, we report that angptl4 mRNA is expressed in 100% of both sporadic (n = 102) and inherited (n = 6) primary ccRCCs, without any statistical association with nuclear grade (p = 0.39), tumor size (p = 0.09), stage grouping (p = 0.17), progression-free survival (p = 0.94), and overall survival (p = 0.80). Angptl4 mRNA was also expressed in 26 (87%) of 30 secondary ccRCCs but neither in any other secondary RCCs (n = 7). In contrast, angptl4 mRNA was neither expressed in 94% non-ccRCC renal tumors (papillary RCCs (n = 46), chromophobe RCCs (n = 28), and oncocytomas (n = 9)), nor in non-renal clear cell carcinomas (n = 39). Angptl4 expression was also examined in tumors associated (n = 23) or not associated (n = 66) with VHL disease. 40 (98%) hemangioblastomas expressed angptl4 whereas all pheochromocytomas (n = 23) and pancreatic tumors (n = 25) were angptl4-negative, whatever their VHL status. CONCLUSIONS/SIGNIFICANCE: Angptl4 mRNA expression was highly associated with ccRCC (p = 1.5 10(-49), Chi square test) allowing to define its expression as a diagnosis marker for primary ccRCC. Moreover, angptl4 mRNA allows to discriminate the renal origin of metastases of clear-cell carcinomas arising from various organs. Finally, inactivation of VHL gene is neither necessary nor sufficient for angptl4 mRNA induction.

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Fichiers liés : journal.pone.0010421.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Stéphanie PacePhilippe GonzalezJean-Marie DevoisselleP.E. MilhietDaniel BrunelFrédérique Cunin
• Organismes : Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Centre de Biochimie Structurale [Montpellier] Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier
• Publié dans New Journal of Chemistry le 01/11/2020

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2010
• Auteurs : Nordine HelassaSylvie NoinvillePhilippe DejardinJean-Marc JanotHervé QuiquampoixSiobhán Staunton
• Organismes : Ecologie Fonctionnelle et Biogéochimie des Sols Laboratoire de Dynamique Interactions et Réactivité Institut Européen des membranes Institut Européen des membranes Ecologie Fonctionnelle et Biogéochimie des Sols Ecologie Fonctionnelle et Biogéochimie des Sols

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Résumé : About 40% of genetically modified crops contain the insecticidal trait engineered from the soil bacterium Bacillus thuringiensis. Plants produce an insectidal protein and it is important to understand how the interactions of this protein with soil influence its persistence and its biological properties. We have used various techniques to monitor the interactions of one such toxin, Cry1Aa with soils and minerals. We have investigated the persistence of the toxin as a function of soil properties and microbial activity and conclude that microbial decay is not the determinant factor in the observed decline of toxin in soil.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Maryvonne Arnaud.Daniel BougnouxJean-Pierre ChambonLuc GwiazdzinskiBernard MalletPhilippe MouillonHenry Torgue. Xochipilli
• Organismes : Pacte, Laboratoire de sciences sociales
• Publié dans Local contemporain le 26/10/2020

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Résumé : Quelle est aujourd'hui la place de la foule ? Pourquoi assiste-t-on à un effondrement de la pensée de la foule après un siècle dédié aux masses ? La foule est-elle une survivance désuète, active seulement dans les mégapoles du sud ? Qu'est-ce, au fond, qu'une foule ? Qu'est-ce qui différencie les foules choisies des foules involontaires ? Pourquoi les aménageurs urbains rêvent-ils d'attirer des foules plus nombreuses grâce à de nouveaux événements ? La foule fait-elle la ville ? Ou est-ce la ville qui invente la foule ? C'est à ce type de questions que répondent les auteurs, à travers quatre parties : L'épreuve du nombre (une physique des foules) ; Le grand corps du multiple (une biologie des foules) ; Humeurs et intelligences (une grammaire émotionnelle des foules) ; Messes et masses (une économie politique des foules).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Carlos Aguilar MelchorChristophe ChabotPhilippe Gaborit
• Organismes : DMI Calculs Algébriques et Systèmes Dynamiques Institut de Recherche Mathématique de Rennes DMI
• Publié dans International Journal of Information and Coding Theory le 26/10/2020

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Résumé : In this paper, we prove that there is no Euclidean self-dual quaternary [18, 9, 7] code for the Hamming distance. The proof is based on a generalisation of the balance principle to Euclidean self-dual quaternary codes. We prove that the existence of an [18, 9, 7] Euclidean self-dual quaternary code implies the existence of an [11, 3, 7] Euclidean self-orthogonal code, which non-existence is proven. We give an up-to-date table for Euclidean self-dual quaternary codes.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Valérie EminJean-Philippe PerninJose- Luis Aguirre-Cervantes
• Organismes : Sciences et Société ; Historicité, Éducation et Pratiques Modèles et Technologies pour l’Apprentissage Humain Laboratoire d'Informatique de Grenoble

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Résumé : This paper concerns the ScenEdit authoring environment, a graphical tool dedicated to design learning scenarios. The environment allows teacher-designers to structure the design of scenarios by eliciting intentions, strategies and interactions included in the ISIS goal-oriented framework. ScenEdit aims to favor sharing and reusing practices by providing patterns for each type of component (intention, strategy and interactional situation). We present here the main functionalities of the environment through an example of a learning scenario.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Jean-Philippe CointetCamille Roth
• Organismes : Centre de Recherche en Epistémologie Appliquée Institut des Systèmes Complexes - Paris Ile-de-France Sciences en Société Institut francilien recherche, innovation et société Centre de Recherche en Epistémologie Appliquée Institut des Systèmes Complexes - Paris Ile-de-France Centre d'Analyse et de Mathématique sociales University of Surrey

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Philippe RicaudBenjamin GabardSolène DerrienJean-Pierre ChaboureauThomas RoseAndreas MombauerHarald Czekala
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Centre de Recherches Atmosphériques Laboratoire d'aérologie Fraunhofer Institute for Applied Information Technology RPG Radiometer Physics GmbH
• Publié dans IEEE Transactions on Geoscience and Remote Sensing le 31/10/2020

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Résumé : The H2O Antarctica Microwave Stratospheric and Tropospheric Radiometers (HAMSTRAD) program aims to develop two ground-based microwave radiometers to sound tropospheric and stratospheric water vapor (H2O) above Dome C (Concordia Station), Antarctica (75??06' S, 123??21'E, 3233 m asml), an extremely cold and dry environment, over decades. By using state-of-the-art technology, the HAMSTRAD-Tropo radiometer uses spectral information in the domains 51-59 GHz (oxygen line) and 169-197 GHz (water vapor line) to derive accurate tropospheric profiles of temperature (with accuracy ranging from 1 to 2 K) and low absolute humidity (with accuracy ranging from 0.02 to 0.05 g ?? m-3), together with integrated water vapor (with accuracy of about 0.008 kg ?? m-2) and liquid water path. Prior to its installation at Dome C in January 2009, the fully automated radiometer has been deployed at the Pic du Midi (PdM, 42??56'N, 0??08'E, 2877 m asml, France) in February 2008 and was in operation for five months. Preliminary comparisons with radio soundings particularly launched in the vicinity of PdM in February 2008 and the outputs from the mesoscale MESO-NH model show a great consistency to within 0.2-0.3 g ?? m-3 between all absolute humidity data sets whatever the atmosphere considered (extremely dry or wet).

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Fichiers liés : Ricaud2010.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : René LiseauCarlos EiroaD. FedeleJean-Charles AugereauGoran OlofssonB. GonzálezJesús MaldonadoB. MontesinosA. MoraOlivier AbsilDavid ArdilaDavid BarradoAmelia BayoCharles A. BeichmanG. BrydenWilliam C. DanchiCarlos del BurgoSteve ErtelMalcolm C. FridlundA. M. HerasAlexander V. KrivovRalf LaunhardtJ. LebretonT. LöhneJ. P. MarshallGwendolyn MeeusS. MüllerG. L. PilbrattA. RobergeJ. RodmannE. SolanoKarl R. StapelfeldtPhilippe ThébaultGlenn J. WhiteSebastian Wolf
• Organismes : Onsala Space Observatory, Chalmers University of Technology Universidad Autónoma de Madrid Universidad Autónoma de Madrid Laboratoire d'Astrophysique de Grenoble Stockholm Observatory, AlbaNova University Center Agence Spatiale Européenne = European Space Agency Universidad Autónoma de Madrid Centro de Astrobiologia [Madrid] Universidad Autónoma de Madrid Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Spitzer Science Center, California Institute of Technology Centro de Astrobiologia [Madrid] Centro de Astrobiologia [Madrid] NASA Exoplanet Science Institute, California Institute of Technology, Pasadena Jet Propulsion Laboratory NASA Goddard Space Flight Center Computational Intelligence Research Group Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA Astrophysikalisches Institut und Universitäts-Sternwarte Max-Planck-Institut für Astronomie Laboratoire d'Astrophysique de Grenoble Astrophysikalisches Institut und Universitäts-Sternwarte Department of Physics and Astronomy, Open University, Walton Hall Universidad Autónoma de Madrid Astrophysikalisches Institut und Universitäts-Sternwarte ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA NASA Goddard Space Flight Center ESA Space Environment and Effects Section, ESTEC Centro de Astrobiologia [Madrid] Jet Propulsion Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique Department of Physics and Astronomy, Open University, Walton Hall Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. About two dozen exo-solar debris systems have been spatially resolved. These debris discs commonly display a variety of structural features such as clumps, rings, belts, excentric distributions and spiral patterns. In most cases, these features are believed to be formed, shaped and maintained by the dynamical influence of planets orbiting the host stars. In very few cases has the presence of the dynamically important planet(s) been inferred from direct observation. Aims: The solar-type star q¹ Eri is known to be surrounded by debris, extended on scales of ⪅30''. The star is also known to host at least one planet, albeit on an orbit far too small to make it responsible for structures at distances of tens to hundreds of AU. The aim of the present investigation is twofold: to determine the optical and material properties of the debris and to infer the spatial distribution of the dust, which may hint at the presence of additional planets. Methods: The Photodetector Array Camera and Spectrometer (PACS) aboard the Herschel Space Observatory allows imaging observations in the far infrared at unprecedented resolution, i.e. at better than 6'' to 12'' over the wavelength range of 60 mum to 210 mum. Together with the results from ground-based observations, these spatially resolved data can be modelled to determine the nature of the debris and its evolution more reliably than what would be possible from unresolved data alone. Results: For the first time has the q¹ Eri disc been resolved at far infrared wavelengths. The PACS observations at 70 mum, 100 mum and 160 mum reveal an oval image showing a disc-like structure in all bands, the size of which increases with wavelength. Assuming a circular shape yields the inclination of its equatorial plane with respect to that of the sky, i > 53°. The results of image de-convolution indicate that i likely is larger than 63°, where 90° corresponds to an edge-on disc. Conclusions: The observed emission is thermal and optically thin. The resolved data are consistent with debris at temperatures below 30 K at radii larger than 120 AU. From image de-convolution, we find that q¹ Eri is surrounded by an about 40 AU wide ring at the radial distance of ~85 AU. This is the first real Edgeworth-Kuiper Belt analogue ever observed.

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