Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Anouchka Guyon-DebastAlain LécureuilSandrine BonhommePhilippe GuercheJean-Luc Gallois
• Organismes : Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Institut Jean-Pierre Bourgin Génétique et Amélioration des Fruits et Légumes
• Publié dans BMC Plant Biology le 22/10/2020

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Résumé : Background: The proteasome subunit RPT5, which is essential for gametophyte development, is encoded by two genes in Arabidopsis thaliana; RPT5a and RPT5b. We showed previously that RPT5a and RPT5b are fully redundant in the Columbia (Col-0) accession, whereas in the Wassilewskia accession (Ws-4), RPT5b does not complement the effect of a strong rpt5a mutation in the male gametophyte, and only partially complements rpt5a mutation in the sporophyte. RPT5bCol-0 and RPT5bWs-4 differ by only two SNPs, one located in the promoter and the other in the seventh intron of the gene. Results: By exploiting natural variation at RPT5b we determined that the SNP located in RPT5b intron seven, rather than the promoter SNP, is the sole basis of this lack of redundancy. In Ws-4 this SNP is predicted to create a new splicing branchpoint sequence that induces a partial mis-splicing of the pre-mRNA, leading to the introduction of a Premature Termination Codon. We characterized 5 accessions carrying this A-to-T substitution in intron seven and observed a complete correlation between this SNP and both a 10 to 20% level of the RPT5b pre-mRNA missplicing and the lack of ability to complement an rpt5a mutant phenotype. Conclusion: The accession-dependent unequal redundancy between RPT5a and RPT5b genes illustrates an example of evolutionary drifting between duplicated genes through alternative splicing.

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Fichiers liés : 39147_20101228091359389_1.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2010
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : René LiseauCarlos EiroaD. FedeleJean-Charles AugereauGoran OlofssonB. GonzálezJesús MaldonadoB. MontesinosA. MoraOlivier AbsilDavid ArdilaDavid BarradoAmelia BayoCharles A. BeichmanG. BrydenWilliam C. DanchiCarlos del BurgoSteve ErtelMalcolm C. FridlundA. M. HerasAlexander V. KrivovRalf LaunhardtJ. LebretonT. LöhneJ. P. MarshallGwendolyn MeeusS. MüllerG. L. PilbrattA. RobergeJ. RodmannE. SolanoKarl R. StapelfeldtPhilippe ThébaultGlenn J. WhiteSebastian Wolf
• Organismes : Onsala Space Observatory, Chalmers University of Technology Universidad Autónoma de Madrid Universidad Autónoma de Madrid Laboratoire d'Astrophysique de Grenoble Stockholm Observatory, AlbaNova University Center Agence Spatiale Européenne = European Space Agency Universidad Autónoma de Madrid Centro de Astrobiologia [Madrid] Universidad Autónoma de Madrid Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Spitzer Science Center, California Institute of Technology Centro de Astrobiologia [Madrid] Centro de Astrobiologia [Madrid] NASA Exoplanet Science Institute, California Institute of Technology, Pasadena Jet Propulsion Laboratory NASA Goddard Space Flight Center Computational Intelligence Research Group Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA Astrophysikalisches Institut und Universitäts-Sternwarte Max-Planck-Institut für Astronomie Laboratoire d'Astrophysique de Grenoble Astrophysikalisches Institut und Universitäts-Sternwarte Department of Physics and Astronomy, Open University, Walton Hall Universidad Autónoma de Madrid Astrophysikalisches Institut und Universitäts-Sternwarte ESA Astrophysics & Fundamental Physics Missions Division, ESTEC/SRE-SA NASA Goddard Space Flight Center ESA Space Environment and Effects Section, ESTEC Centro de Astrobiologia [Madrid] Jet Propulsion Laboratory Laboratoire d'études spatiales et d'instrumentation en astrophysique Department of Physics and Astronomy, Open University, Walton Hall Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. About two dozen exo-solar debris systems have been spatially resolved. These debris discs commonly display a variety of structural features such as clumps, rings, belts, excentric distributions and spiral patterns. In most cases, these features are believed to be formed, shaped and maintained by the dynamical influence of planets orbiting the host stars. In very few cases has the presence of the dynamically important planet(s) been inferred from direct observation. Aims: The solar-type star q¹ Eri is known to be surrounded by debris, extended on scales of ⪅30''. The star is also known to host at least one planet, albeit on an orbit far too small to make it responsible for structures at distances of tens to hundreds of AU. The aim of the present investigation is twofold: to determine the optical and material properties of the debris and to infer the spatial distribution of the dust, which may hint at the presence of additional planets. Methods: The Photodetector Array Camera and Spectrometer (PACS) aboard the Herschel Space Observatory allows imaging observations in the far infrared at unprecedented resolution, i.e. at better than 6'' to 12'' over the wavelength range of 60 mum to 210 mum. Together with the results from ground-based observations, these spatially resolved data can be modelled to determine the nature of the debris and its evolution more reliably than what would be possible from unresolved data alone. Results: For the first time has the q¹ Eri disc been resolved at far infrared wavelengths. The PACS observations at 70 mum, 100 mum and 160 mum reveal an oval image showing a disc-like structure in all bands, the size of which increases with wavelength. Assuming a circular shape yields the inclination of its equatorial plane with respect to that of the sky, i > 53°. The results of image de-convolution indicate that i likely is larger than 63°, where 90° corresponds to an edge-on disc. Conclusions: The observed emission is thermal and optically thin. The resolved data are consistent with debris at temperatures below 30 K at radii larger than 120 AU. From image de-convolution, we find that q¹ Eri is surrounded by an about 40 AU wide ring at the radial distance of ~85 AU. This is the first real Edgeworth-Kuiper Belt analogue ever observed.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : R. FarèsJean-François DonatiClaire MoutouM. M. JardineJean-Mathias GriessmeierPhilippe ZarkaE. L. ShkolnikDavid A. BohlenderClaude CatalaA. C. Cameron
• Organismes : Laboratoire Astrophysique de Toulouse-Tarbes Laboratoire d'Astrophysique de Marseille Laboratoire Astrophysique de Toulouse-Tarbes Laboratoire d'Astrophysique de Marseille School of Physics and Astronomy, University of St Andrews Netherlands Institute for Radio Astronomy Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas Department of Terrestrial Magnetism, Carnegie Institution of Washington National Research Council of Canada Laboratoire d'études spatiales et d'instrumentation en astrophysique Physique des plasmas School of Physics and Astronomy, University of St Andrews
• Publié dans Monthly Notices of the Royal Astronomical Society le 30/10/2020

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Résumé : HD189733 is a K2 dwarf, orbited by a giant planet at 8.8 stellar radii. In order to study magnetospheric interactions between the star and the planet, we explore the large-scale magnetic field and activity of the host star.

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Fichiers liés : j.1365-2966.2010.16715.x.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2010
• Auteurs : René QuiniouLucie CallensGuy CarraultMarie-Odile CordierElisa FromontPhilippe MaboFrançois Portet
• Organismes : Diagnosing, Recommending Actions and Modelling Diagnosing, Recommending Actions and Modelling Laboratoire Traitement du Signal et de l'Image Diagnosing, Recommending Actions and Modelling Laboratoire Hubert Curien Laboratoire Traitement du Signal et de l'Image Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Laboratoire d'Informatique de Grenoble

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Résumé : Monitoring patients in intensive care units is a critical task. Simple condition detection is generally insufficient to diagnose a patient and may generate many false alarms to the clinician operator. Deeper knowledge is needed to discriminate among the flow of alarms those that necessitate urgent therapeutic action. Overall, it is important to take into account the monitoring context: sensor and signal context (are the signal data noisy or clear?), the patient condition (is the state of the patient evolving or stable? is the condition of the patient critical or safe?), the environmental context (do the external conditions influence the patient condition or not?). To achieve the best surveillance as possible, we propose an intelligent monitoring system that makes use of several artificial intelligence techniques: artificial neural networks for signal processing and temporal abstraction, temporal reasoning, model based diagnosis, decision rule based system for adaptivity and machine learning for knowledge acquisition. To tackle the difficulty of taking context change into account, we introduce a pilot aiming at adapting the system behavior by reconfiguring or tuning the parameters of the system modules. A prototype has been implemented and is currently experimented and evaluated. Some results, showing the benefits of the approach, are given.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Benoit BaudryPierre BazexJean-Charles DalbinPhilippe DhaussyHubert DuboisChristian PerceboisErwann PoupartLaurent Sabatier
• Organismes : Reliable and efficient component based software engineering Modèles, Architectures, Composants, Agilité et prOcessus Airbus [France] Laboratoire d'Informatique des Systèmes Complexes Laboratoire d'Intégration des Systèmes et des Technologies Modèles, Architectures, Composants, Agilité et prOcessus Centre National d'Études Spatiales [Toulouse] SODIFRANCE - Nantes

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Résumé : A large number of modeling activities can be automatic or computer assisted. This automation ensures a more rapid and robust software development. However, engineers must ensure that the models have the properties required for the application. In order to tend towards this requirement, the DOMINO project (DOMaINs and methodological prOcess) proposes to use the socalled trustworthy Model-Driven Engineering (MDE) components and aims to provide a methodology for the validation and qualification of such components.

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Fichiers liés : Baudry10a.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Nicolas BarbierPierre CouteronChristophe ProisyYadvinder MalhiJean-Philippe Gastellu-Etchegorry
• Organismes : Laboratoire de Complexité et Dynamique des Systèmes Tropicaux, Research Fellow FNRS Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Centre for the Environment, Centre d'études spatiales de la biosphère
• Publié dans Global Ecology and Biogeography le 25/10/2020

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Résumé : Aim: The size structure of a forest canopy is an important descriptor of the forest environment that may yield information on forest biomass and ecology. However, its variability at regional scales is poorly described or understood because of the still prohibitive cost of very high-resolution imagery as well as the lack of an appropriate methodology. We here employ a novel approach to describe and map the canopy structure of tropical forests. Location Amazonia. Methods: We apply Fourier transform textural ordination (FOTO) techniques to subsamples of very high-resolution satellite imagery freely available through virtual globe software (e.g. Google Earth®) to determine two key structural variables: apparent mean crown size and heterogeneity in crown size. A similar approach is used with artificial forest canopy images generated by the light interaction model (discrete anisotropic radiative transfer, DART) using three-dimensional stand models. The effects of sun and viewing angles are explored on both model and real data. Results: It is shown that in the case of canopies dominated by a modal size class our approach can predict mean canopy size to an accuracy of 5%. In Amazonia, we could evidence a clear macrostructure, despite considerable local variability. Apparent crown size indeed consistently increases from about 14 m in wet north-west Amazonia to more than 17 m for areas of intermediate dry season length (1–3 months) in south and east Amazonia, before decreasing again towards the ecotone with the Cerrado savanna biome. This general trend reflects the known variation of other forest physiognomic properties (height) reported for South America and Africa. Some regions show significantly greater canopy heterogeneity, a feature that may be related to substratum, perturbation rate and/or forest turnover rate. Main conclusions: Our results demonstrate the feasibility and interest of large-scale assessment of rain forest canopy structure

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2010
• Auteurs : Yonghua Li-BeissonBasil ShorroshFred BeissonMats X. AnderssonVincent ArondelPhilippe D. BatesSébastien BaudDavid BirdAllan DebonoTimithy P. DurrettRochus B. FrankeIan A. GrahamKenta KatayamaAmelie A. KellyTony LarsonJonathan E. MarkhamMartine MiquelIsabel MolinaIkuo NishidaOwen RowlandLacey SamuelsKatherine M. SchmidHajime WadaRuth WeltiChangcheng XuRémi ZallotJohn Ohlrogge
• Organismes : Environnement, Bioénergie, Microalgues et Plantes Wirestone L.L.C. Environnement, Bioénergie, Microalgues et Plantes Department of Plant and Environmental Sciences Laboratoire de biogenèse membranaire Institute of Biological Chemistry Institut Jean-Pierre Bourgin Department of Chemical and Biological Sciences Independent Michigan State University [East Lansing] Rheinische Friedrich-Wilhelms-Universität Bonn Centre for Novel Agricultural Products, Department of Biology Independent University of Warwick [Coventry] Centre for Novel Agricultural Products, Department of Biology Donald Danforth Plant Science Center Institut Jean-Pierre Bourgin Algoma University Saitama University Department of Biology and Institute of Biochemistry Department of Botany Butler University The University of Tokyo Kansas Lipidomics Research Center, Division of Biology Brookhaven National Laboratory [Upton, NY] Laboratoire de biogenèse membranaire Independent

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Résumé : Lipides acyle dans Arabidopsis et toutes les autres plantes ont une myriade de fonctions diverses. Il s'agit notamment de fournir la barrière de diffusion de base des membranes qui sépare les cellules et les organites subcellulaires. Cette fonction implique seuls plus de 10 classes de lipides membranaires, y compris les phospholipides, galactolipides, et sphingolipides, et au sein de chaque classe, les variations dans la composition de la chaîne acyle augmenter le nombre de structures à plusieurs centaines de possibles espèces moléculaires. Lipides acyle dans le sous forme de compte triacylglycérol de 35% du poids de graines d'Arabidopsis et représentent leur forme majeure de carbone et de stockage d'énergie. Une couche de cutine et les cires cuticulaires qui limite la perte d'eau et offre une protection contre les invasions par des agents pathogènes et autres stress recouvre toute la surface aérienne d'Arabidopsis. Des fonctions similaires sont fournis par la subérine et des cires associés qui sont localisées dans les racines, les téguments et les zones d'abscission et sont produites en réponse à une blessure. Ce chapitre se concentre sur les voies métaboliques qui sont associés à la biosynthèse et la dégradation des lipides acyle mentionnés ci-dessus. Ces voies, les enzymes et les gènes sont également présentés en détail dans un site Web associé (ARALIP: http://aralip.plantbiology.msu.edu/ ). Protocoles et méthodes utilisés pour l'analyse des lipides Arabidopsis sont fournis. Enfin, un résumé détaillé de la composition des lipides Arabidopsis est fourni en trois chiffres et 15 tables.

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• Type de publi. : Article dans une revue
• Date de publi. : 29/12/2009
• Auteurs : Julien VinitGéraldine MullerPhilip BielefeldPierre PfitzenmeyerPhilippe BonniaudBernard LorcerieJean-François Besancenot
• Organismes : Service de médecine interne et des maladies sytémiques (hôpital général, CHU Dijon) Service de médecine interne et des maladies sytémiques (hôpital général, CHU Dijon) Service de médecine interne et des maladies sytémiques (hôpital général, CHU Dijon) Service de médecine gériatrique (CHU de Dijon - Centre gériatrique de Champmaillot - EHPAD) Service des maladies respiratoires [CHU de Dijon] Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon] Service de médecine interne et des maladies sytémiques (hôpital général, CHU Dijon)
• Publié dans Rheumatology International le 29/10/2020

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Résumé : Churg-Strauss Syndrome (SCS) is a systemic vasculitis associated with asthma and eosinophilia. The aim of our work is to describe this pathology in the Burgundian population in France. We counted from the hospitalisation data-processing summaries, the whole of the SCS hospitalised in Burgundy between 1998 and 2008. During the follow-up, the clinical and paraclinical characteristics of every patient were collected. The average prevalence is of 11.3 per million inhabitants and the incidence is of 1.2 new cases per million inhabitants per annum. There exists however, a great prevalence disparity and incidence amongst the various departments of the area. The patient's average follow-up is of 7.7 years. In 23% of the cases one finds a starting factor for vasculitis. The delay between the first signs and the diagnostic is an average of 61 months. The ANCA are positive in 26% of cases and of anti-myeloperoxidase specificity in 83% of cases ( < 0.001). The most profitable biopsies are essentially cutaneous and neuromuscular. At the diagnostic, two-third of the patients have had a treatment adapted according to the current recommendations based on the Five Factor Score. The remission rate within a 1-year period is of 77%. The remission is strongly correlated to the therapeutic protocol associating corticoids and cyclophosphamide ( < 0.05). In conclusion, the prevalence of SCS in our area is similar to that observed in other European regions. However, this vasculitis remains a difficult and often a tardive diagnostic pathology.

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Fichiers liés : PEER_stage2_10.1007%2Fs00296-009-1275-y.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/12/2009
• Auteurs : Mickaël BourgoinMichael BerhanuBasile GalletRomain MonchauxPhilippe OdierJean-François PintonNicolas PlihonRomain VolkStéphan FauveNicolas MordantFrançois PétrélisSébastien AumaîtreArnaud ChiffaudelFrançois DaviaudBérengère DubrulleFlorent Ravelet
• Organismes : Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] Laboratoire de Physique Statistique de l'ENS Laboratoire de Physique Statistique de l'ENS Service de physique de l'état condensé Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique de l'ENS Lyon Laboratoire de Physique Statistique de l'ENS Laboratoire de Physique Statistique de l'ENS Laboratoire de Physique Statistique de l'ENS Service de physique de l'état condensé Service de physique de l'état condensé Service de physique de l'état condensé Service de physique de l'état condensé Service de physique de l'état condensé Laboratoire de Dynamique des Fluides
• Publié dans Journal of Fluid Mechanics le 26/10/2020

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Résumé : We report the first experimental observation of a bistable dynamo regime. A turbulent flow of liquid sodium is generated between two disks ill the von karman geometry (VKS experiment). When one disk is kept at rest, bistability is observed between a stationary and an oscillatory magnetic field. The stationary and oscillatory branches occur in the vicinity of a codimension-two bifurcation that results from the coupling between two modes of magnetic field. We present an experimental study or the two regimes and study in detail the region of bistability that we understand ill terms of dynamical system theory. Despite the very turbulent nature of the flow, the bifurcations of the magnetic field are correctly described by a low-dimensional model. In addition, the different regimes are robust; i.e. turbulent fluctuations do not drive any transition between the oscillatory and stationary states in the region of bistability.

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Fichiers liés : Berhanu2009_JFM.pdf

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