Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Xavier de BoissezonNathalie MarieEvelyne Castel-LacanalPhilippe MarqueCatherine BezyHélène GrosJean-Albert LotterieDominique CardebatMichèle PuelJean-François Démonet
• Organismes : Service Médecine physique et de réadaptation [CHU Toulouse] Imagerie cérébrale et handicaps neurologiques Imagerie cérébrale et handicaps neurologiques Service Médecine physique et de réadaptation [CHU Toulouse] Imagerie cérébrale et handicaps neurologiques Service Médecine physique et de réadaptation [CHU Toulouse] Imagerie cérébrale et handicaps neurologiques Imagerie cérébrale et handicaps neurologiques Neurologie générale et maladies inflammatoires du système nerveux [Toulouse] Imagerie cérébrale et handicaps neurologiques Service de Médecine Nucléaire - Pierre-Paul Riquet [CHU Toulouse] Imagerie cérébrale et handicaps neurologiques Imagerie cérébrale et handicaps neurologiques Neurologie générale et maladies inflammatoires du système nerveux [Toulouse] Imagerie cérébrale et handicaps neurologiques Neurologie générale et maladies inflammatoires du système nerveux [Toulouse] Imagerie cérébrale et handicaps neurologiques Neurologie générale et maladies inflammatoires du système nerveux [Toulouse]
• Publié dans Eur J Phys Rehabil Med le 04/01/2010

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Résumé : AIM: It has long been a matter of debate whether recovery from aphasia after left perisylvian lesion is mediated by perilesional left hemispheric regions or by right homologous areas. To investigate the neural substrates of aphasia recovery, a longitudinal study in patients after a left single perisylvian stroke was performed. METHODS: Thirteen aphasic patients were H2(15)O PET-scanned twice at a one year interval during a word generation task. Patients are divided into two groups according to language performance for the word generation task at PET2. For the Good Recovery (GR) group, patients' performances are indistinguishable from those of normal subjects, while patients from the Poor Recovery (PR) group keep language disorders. Using SPM2, Language-Rest contrast is computed for both groups at both PET stages. Then, Session Effect contrast (TEP2-TEP1>0) is calculated for both groups. RESULTS: For the GR group, the Session Effect contrast shows an increase of activations in the left Postero-Superior Temporal Gyrus PSTG but also in the right thalamus and lenticular nuclei; for PR patients, the right lenticular nucleus activation is more important at PET1 than PET2. CONCLUSIONS: The crucial role of the left temporal activation is confirmed and its increase is linked to behavioural recovery. The role of the right basal ganglia to support good recovery from aphasia is a new finding. Their activation may be more task-dependant and related to inhibition of the right frontal cortex.

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Fichiers liés : ArticleGRPR_EJPRM_HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Jean-Philippe TalarminDavid BoutoilleP. TattevinS. DargèrePierre WeinbreckS. AnsartJ.-M. ChennebaultP. HutinS. Léautez-NainvilleF. Gay-AndrieuF. RaffiGericco Groupe d'Épidémiologie Et de Recherche En Infectiologie Clinique Du Centre-Ouest
• Organismes : Service des maladies infectieuses et tropicales [CHU Nantes] Service des maladies infectieuses et tropicales [CHU Nantes] Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes] Unité de Maladies Infectieuses et Tropicales [CHU Caen] Service des Maladies infectieuses et tropicales [CHU Limoges] Equipe de Recherche Médicale Appliquée Service de médecine interne 2 et maladies infectieuses Service des maladies infectieuses et tropicales Service de médecine générale, interne, infectiologie, maladies du sang Service de médecine post-urgence Laboratoire de parasitologie-mycologie Service des maladies infectieuses et tropicales [CHU Nantes]
• Publié dans Médecine et Maladies Infectieuses (1971-2020) le 28/10/2020

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Résumé : OBJECTIVE: A one-year prospective, observational study was conducted in the west of France, to evaluate the epidemiology of candidemia. METHOD: During the year 2004, each patient with at least one blood culture yielding Candida sp. was included. For each episode of candidemia, mycological, demographical, clinical, and therapeutic data, as well as outcome, were collected. RESULTS: One hundred and ninety-three strains of Candida sp. were isolated in 186 patients, Candida albicans accounting for 54.9%, Candida glabrata for 18.7%, Candida parapsilosis for 12.9%, Candida tropicalis for 4.7% and Candida krusei for 4.1% of these isolates. A percentage of 84% of the Candida isolates were fully susceptible to fluconazole in vitro. Dose-dependent susceptibility or resistance to fluconazole was detected in more than one third of the Candida glabrata strains, of which 36% were also resistant to voriconazole. Two-thirds of the patients were males, and the mean age was 61.5 years. A percentage of 37% of patients were hospitalized in intensive care units. The main predisposing factors for candidemia were broad-spectrum antibiotics (75.8%), central venous catheter (72.6%), cancer or hematologic malignancy (47.3%), recent surgery (42.5%), total parenteral nutrition (37.6%). One hundred and fifty-four patients were treated with antifungal therapy, two-thirds of whom received fluconazole as first-line agent. Mortality was 49% overall, and was significantly higher in case of septic shock, advanced age, and absence of catheter removal.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Daniel BéharPhilippe EstèbeMartin Vanier
• Organismes : Centre de recherche Espace, Transport, Environnement et Institutions locales Centre Interdisciplinaire de Recherches Urbaines et Sociologiques Pacte, Laboratoire de sciences sociales
• Publié dans Pouvoirs Locaux : les cahiers de la décentralisation / Institut de la décentralisation le 01/11/2020

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Résumé : En France, régulièrement, les territoires entrent en turbulence, dans le cadre de tel ou tel projet de réforme territoriale qui poursuit la quête de l'idéal moderne d'une architecture rationnelle des collectivités locales. Le point de vue développé dans cet article est en faveur d'une interterritorialité qui ne nécessite pas tant une nouvelle réforme, qu'une évolution des règles du fonctionnement politique des territoires.

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Fichiers liés : Mecano_territorial.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Philippe DecaudinFabrice Neyret
• Organismes : Virtual environments for animation and image synthesis of natural objects Acquisition, representation and transformations for image synthesis
• Publié dans Computer Graphics Forum le 30/10/2020

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Résumé : We introduce an image-based representation, called volumetric billboards, allowing for the real-time rendering of semi-transparent and visually complex objects arbitrarily distributed in a 3D scene. Our representation offers full parallax effect from any viewing direction and improved anti-aliasing of distant objects. It correctly handles transparency between multiple and possibly overlapping objects without requiring any primitive sorting. Furthermore, volumetric billboards can be easily integrated into common rasterization-based renderers, which allows for their concurrent use with polygonal models and standard rendering techniques such as shadow-mapping. The representation is based on volumetric images of the objects and on a dedicated real-time volume rendering algorithm that takes advantage of the GPU geometry shader. Our examples demonstrate the applicability of the method in many cases including levels-of-detail representation for multiple intersecting complex objects, volumetric textures, animated objects and construction of high-resolution objects by assembling instances of lowresolution volumetric billboards.

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Fichiers liés : VolumetricBillboards_CGF09.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Vincent ProbstArthur a M WildeJulien BarcFrederic SacherDominique BabutyPhilippe MaboJacques MansouratiSolena Le ScouarnecFlorence KyndtCédric Le CaignecPascale GuicheneyLaetitia GouasJuliette AlbuissonPaola G MeregalliHervé Le MarecHanno L TanJean-Jacques Schott
• Organismes : Department of Cardiology [Amsterdam] ITX - unité de recherche de l'institut du thorax Service de rythmologie Centre Hospitalier Régional Universitaire de Tours Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] Service de cardiologie [Brest] ITX - unité de recherche de l'institut du thorax Service de génétique médicale - Unité de génétique clinique [Nantes] Service de génétique médicale - Unité de génétique clinique [Nantes] Physiopathologie et thérapie du muscle strié Physiopathologie et thérapie du muscle strié Service de génétique médicale - Unité de génétique clinique [Nantes] Department of Cardiology [Amsterdam] Department of Cardiology [Amsterdam] ITX - unité de recherche de l'institut du thorax
• Publié dans Circulation: Cardiovascular Genetics le 26/10/2020

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Résumé : BACKGROUND: Mutations in SCN5A are identified in approximately 20% to 30% of probands affected by Brugada syndrome (BrS). However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the association of SCN5A mutations and BrS in a group of large genotyped families. METHODS AND RESULTS: Families were included if at least 5 family members were carriers of the SCN5A mutation, which was identified in the proband. Thirteen large families composed of 115 mutation carriers were studied. The signature type I ECG was present in 54 mutation carriers (BrS-ECG+; 47%). In 5 families, we found 8 individuals affected by BrS but with a negative genotype (mutation-negative BrS-ECG+). Among these 8 mutation-negative BrS-ECG+ individuals, 3, belonging to 3 different families, had a spontaneous type I ECG, whereas 5 had a type I ECG only after the administration of sodium channel blockers. One of these 8 individuals had also experienced syncope. Mutation carriers had, on average, longer PR and QRS intervals than noncarriers, demonstrating that these mutations exerted functional effects. CONCLUSIONS: Our results suggest that SCN5A mutations are not directly causal to the occurrence of a BrS-ECG+ and that genetic background may play a powerful role in the pathophysiology of BrS. These findings add further complexity to concepts regarding the causes of BrS, and are consistent with the emerging notion that the pathophysiology of BrS includes various elements beyond mutant sodium channels.

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Fichiers liés : SCN5A_Mutations_and_the_Role-accepted.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2009
• Auteurs : Vincent CloutierUmberto CapitanioLaurent ZiniPaul PerrotteClaudio JeldresShahrokh F. ShariatPhilippe ArjaneJean-Jacques PatardFrancesco MontorsiPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcome Unit Service d'urologie Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Institut de Génétique et Développement de Rennes Service d'urologie [Rennes] = Urology [Rennes] Department of urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans European Urology le 23/10/2020

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Résumé : BACKGROUND: The existing literature suggests that the surgical mortality (SM) observed with nephrectomy for localised disease varies from 0.6% to 3.6%. OBJECTIVE: To examine age- and stage-specific 30-d mortality (TDM) rates after partial or radical nephrectomy. DESIGN, SETTING, AND PARTICIPANTS: We relied on 24535 assessable patients from the National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) database. MEASUREMENTS: In 12283 patients, logistic regression models were used to develop a tool for pretreatment prediction of the probability of TDM according to individual patient and tumour characteristics. External validation was performed on 12252 patients. RESULTS AND LIMITATIONS: In the entire cohort of 24535 patients, 219 deaths occurred during the initial 30 d after nephrectomy (0.9% TDM rate). TDM increased with age (≤49 yr: 0.5% vs 50-59 yr: 0.7% vs 60-69 yr: 0.9% vs 70-79 yr: 1.2% vs ≥80 yr: 2.0%; χ(2) trend p<0.001) and stage (0.3% for T1-2N0M0 vs 1.3% for T3-4N0-2M0 vs 4.2% for T1-4N0-2M1; χ2 trend p=<0.001). TDM decreased in more recent years (1988-1993: 1.3% vs 1994-1998: 0.9% vs 1999-2002: 0.7% vs 2003-2004: 0.6%; χ2 trend p<0.001) and was lower after partial versus radical nephrectomy (RN) (0.4% vs 0.9%; p=0.008). Only age (p<0.001) and stage (p<0.001) achieved independent predictor status. The look-up table that relied on the regression coefficients of age and stage reached 79.4% accuracy in the external validation cohort. CONCLUSIONS: Age and stage are the foremost determinants of TDM after nephrectomy. Our model provides individual probabilities of TDM after nephrectomy, and its use should be highly encouraged during informed consent prior to planned nephrectomy.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/11/2009
• Auteurs : Marie-Béatrice Bogeat-TriboulotDavid CohenDidier Le ThiecSandrine BalzergueMartin-Magniette Marie-LaureJean-Pierre RenouPhilippe LabelMarie-Claude Lesage-DescausesFrançoise LauransIsabelle BourgaitAnnabelle DéjardinJean-Charles LepléDomenico MorabitoLudovic BonhommeFranck F. BrignolasDelphine D. VincentChristophe PlomionIrène Hummel
• Organismes : Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Unité de recherche en génomique végétale Unité de recherche en génomique végétale Unité de recherche en génomique végétale Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Unité de recherche Amélioration, Génétique et Physiologie Forestières Génétique Quantitative et Evolution - Le Moulon (Génétique Végétale) Arbres et Réponses aux Contraintes Hydriques et Environnementales Biodiversité, Gènes & Communautés Biodiversité, Gènes & Communautés Ecologie et Ecophysiologie Forestières [devient SILVA en 2018]

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Fichiers liés : 43713_20110405113347958_1.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 24/11/2009
• Auteurs : Martine EckertMitsuhiro HayashibeDavid GuiraudPierre-Brice WieberPhilippe Fraisse
• Organismes : IMERIR Artificial movement and gait restoration Artificial movement and gait restoration Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier

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Résumé : Mathematical models of the skeletal muscle can support the development of neuroprotheses to restore functional movements in individuals with motor deficiencies by the mean of Functional Electrical Stimulation (FES). Since many years, numerous skeletal muscle models have been proposed to express the relationship between muscle activation and generated force. One of them (Makssoud et al [2]-[3]), integrates the Hill model [5] and the physiological one based on Huxley work [4] allowing the muscle activation under FES. We propose in this paper an improvement of this model by modifying the activation part. These improvements are highlighted through the HuMAnS toolbox [1] using a 3D biomechanical model of human named Human 36. This article describes this toolbox and the software implementation of the model. Then, we present the results of the simulation.

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Fichiers liés : Eckert_article_envoye.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/11/2009
• Auteurs : Julien DambrinePhilippe HochRaphaël KuateJérôme LohéacJérôme MetralBernard RebourcetLisl Weynans
• Organismes : Institut de Mathématiques de Bordeaux DAM Île-de-France Laboratoire Jacques-Louis Lions Laboratoire de Spectrométrie Physique Equations aux Dérivées Partielles DAM Île-de-France DAM Île-de-France Institut de Mathématiques de Bordeaux Modélisation, contrôle et calcul
• Publié dans ESAIM: Proceedings le 25/10/2020

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Résumé : Numerous systems of conservation laws are discretized on Lagrangian meshes where cells nodes move with matter. For complex applications, cells shape or aspect ratio often do not insure sufficient accuracy to provide an acceptable numerical solution and use of ALE technics is necessary. Here we are interested with conduction phenomena depending on velocity derivatives coming from the resolution of gas dynamics equations. For that, we propose the study of a mock of second order turbulent mixing model combining an elliptical part and an hyperbolic kernel. The hyperbolic part is approximated by finite-volume centered scheme completed by a remapping step see [7]. A major part of this paper is the discretization of the anisotropic parabolic equation on polygonal distorted mesh. It is based on the scheme described in [9] ensuring the positivity of the numerical solution. We propose an alternative based on the partitioning of polygons in triangles. We show some preliminary results on a weak coupling of hydrodynamics and parabolic equation whose tensor diffusion coefficient depends on Reynolds stresses.

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Fichiers liés : cemracsproceding.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/11/2009
• Auteurs : Hugues GirardSandrine PerruchasCeline GessetMarc ChaigneauLaetitia VieilleJean-Charles ArnaultPhilippe BergonzoJean-Pierre BoilotThierry Gacoin
• Organismes : Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de physique de la matière condensée Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de Physique des Interfaces et des Couches Minces Centre Sciences des Processus Industriels et Naturels Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire Capteurs Diamant (CEA, LIST) Laboratoire de physique de la matière condensée Laboratoire de physique de la matière condensée
• Publié dans ACS Applied Materials & Interfaces le 01/11/2020

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Résumé : Nanodiamond (ND) seeding is a well-established route toward the CVD (chemical vapor deposition) synthesis of diamond ultrathin films. This method is based on the deposition onto a substrate of diamond nanoparticles which act as pre-existing sp$^3$ seeds. Here, we report on a straightforward method to disperse diamond nanoparticles on a substrate by taking advantage of the electrostatic interactions between the nanodiamonds and the substrate surface coated with a cationic polymer. This layer-by-layer deposition technique leads to reproducible and homogeneous large-scale nanoparticle deposits independent of the substrate’s nature and shape. No specific functionalization of the nanoparticles is required, and low concentrated solutions can be used. The density of ND on the substrate can be controlled, as shown by in situ ATR-FTIR (attenuated total reflection Fourier transform infrared) analysis and QCM (quartz crystal microbalance) measurements. Highly dense and compact ND deposits can be obtained, allowing CVD growth of nanocrystalline diamond ultrathin films (70 nm) on various substrates. The synthesis of 3D structured and patterned diamond thin films has also been demonstrated with this method.

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Fichiers liés : article_HuguesGirard_Applied Materials and Interfaces_2009.pdf

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