Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2010
• Auteurs : Philippe MulhemJean-Pierre Chevallet
• Organismes : Modélisation et Recherche d’Information Multimédia [Grenoble] Laboratoire d'Informatique de Grenoble

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Naima G Cortes-PerezCatherine SapinLoïc JaffreloSabine DaouJean Pierre GrillPhilippe LangellaPhilippe SeksikLaurent BeaugerieSerge ChwetzoffGermain Trugnan
• Organismes : Université Pierre et Marie Curie - Paris 6 CHU Saint-Antoine [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Saint-Antoine [AP-HP] Université Pierre et Marie Curie - Paris 6 Université Pierre et Marie Curie - Paris 6 Trafic Membranaire et Signalisation Dans les Cellules Epitheliales
• Publié dans Journal of Biomedicine and Biotechnology le 24/10/2020

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Résumé : The delivery of bioactive molecules directly to damaged tissues represents a technological challenge. We propose here a new system based on virus-like particles (VLP) from rotavirus, with a marked tropism for the gut to deliver bio-active molecules to intestinal cells. For this, nonreplicative VLP nanoparticles were constructed using a baculovirus expression system and used to deliver an exogenous biomolecule, the green fluorescent protein (GFP), into either MA104 cells or intestinal cells from healthy and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-treated mice. Our results show that expression of rotavirus capsid proteins in baculovirus led to the auto assembly of VLP that display similar properties to rotavirus. In vitro experiments showed that VLP were able to enter into MA104 cells and deliver the reporter protein. Intragastric administration of fluorescent VLP in healthy and TNBS-treated mice resulted in the detection of GFP and viral proteins in intestinal samples. Our results demonstrate an efficient entry of non-replicative rotavirus VLP into the epithelial cell line MA104 and provide the first in vivo evidence of the potential of these nanoparticles as a promising safe candidate for drug delivery to intestinal cells.

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Fichiers liés : 317545_1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Philippe BonnardRoger SombiéFrancois-Xavier LescureAlain BougoumaJean-Baptiste Guiard-SchmidThierry PoynardPaul CalèsChantal HoussetPatrice CallardCatherine Le PendevenJoseph DraboFabrice CarratGilles Pialoux
• Organismes : CHU Tenon [AP-HP] Service d’Hépato-gastroentérologie [Ouagadougou, Burkina-Faso] CHU Tenon [AP-HP] Unité de Réseau d'Epidémiologie Clinique International Francophone Centre Hospitalier Universitaire Yalgado Ouédraogo [Ouagadougou, Burkina Faso] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] Université Pierre et Marie Curie - Paris 6 CHU Tenon [AP-HP] Service de Médecine interne Epidémiologie des maladies infectieuses et modélisation CHU Tenon [AP-HP]
• Publié dans American Journal of Tropical Medicine and Hygiene le 25/10/2020

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Résumé :

AbstractLiver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis B. In Burkina Faso, liver biopsy (LB) remains the “gold standard” method for this purpose. Access to treatment might be simpler if reliable alternative techniques for LF evaluation were available. The hepatitis B virus (HBV)-infected patients who underwent LB was invited to have liver stiffness measurement (Fibroscan) and serum marker assays. Fifty-nine patients were enrolled. The performance of each technique for distinguishing F0F1 from F2F3F4 was compared. The area under receiver operating characteristic (AUROC) curves was 0.61, 0.71, 0.79, 0.82, and 0.87 for the aspartate transaminase to platelet ratio index (APRI), Fib-4, Fibrotest, Fibrometre, and Fibroscan. Elastometric thresholds were identified for significant fibrosis and cirrhosis. Combined use of Fibroscan and a serum marker could avoid 80% of biopsies. This study shows that the results of alternative methods concord with those of histology in HBV-infected patients in Burkina Faso. These alternative techniques could help physicians to identify patients requiring treatment.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Jérôme VerineJacqueline Lehmann-CheHany SolimanJean-Paul FeugeasJean-Sébastien VidalPierre Mongiat-ArtusStéphanie BelhadjJosette PhilippeMatthieu LesageEvelyne WittmerStéphane ChanelAnne CouvelardSophie FerlicotNathalie Rioux-LeclercqJean-Michel VignaudAnne JaninStéphane Germain
• Organismes : Service d'anatomo-pathologie [Paris] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Angiogénèse embryonnaire et pathologique Pathologie et virologie moléculaire Laboratoire de biochimie Pathologie et virologie moléculaire Laboratoire de biochimie Pathologie et virologie moléculaire Laboratoire de biochimie Neuroépidémiologie Pathologie et virologie moléculaire Service d'Urologie [CHU Saint-Louis] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Angiogénèse embryonnaire et pathologique Angiogénèse embryonnaire et pathologique Laboratoire de biochimie Laboratoire Pasteur Cerba Laboratoire de Pathologie Laboratoire de Pathologie Service d'anatomie et cytologie pathologiques [Rennes] = Anatomy and Cytopathology [Rennes] Service de Pathologie [CHRU Nancy] Service d'anatomo-pathologie [Paris] Gvh et Gvl : Physiopathologie Chez l'Homme et Chez l'Animal, Incidence et Role Therapeutique Service d'anatomo-pathologie [Paris] Angiogénèse embryonnaire et pathologique
• Publié dans PLoS ONE le 25/10/2020

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Résumé : BACKGROUND: We have previously shown that angiopoietin-like 4 (angptl4) mRNA, a hypoxia-inducible gene, is highly expressed in clear cell renal-cell carcinoma (ccRCC), the most common subtype of RCC for which no specific marker is available. We here investigated whether angptl4 mRNA 1) could be a useful diagnostic and/or prognostic marker of ccRCC in a large and comprehensive retrospective series, 2) induction is dependent on the VHL status of tumors. METHODOLOGY/PRINCIPAL FINDINGS: Using in situ hybridization, we report that angptl4 mRNA is expressed in 100% of both sporadic (n = 102) and inherited (n = 6) primary ccRCCs, without any statistical association with nuclear grade (p = 0.39), tumor size (p = 0.09), stage grouping (p = 0.17), progression-free survival (p = 0.94), and overall survival (p = 0.80). Angptl4 mRNA was also expressed in 26 (87%) of 30 secondary ccRCCs but neither in any other secondary RCCs (n = 7). In contrast, angptl4 mRNA was neither expressed in 94% non-ccRCC renal tumors (papillary RCCs (n = 46), chromophobe RCCs (n = 28), and oncocytomas (n = 9)), nor in non-renal clear cell carcinomas (n = 39). Angptl4 expression was also examined in tumors associated (n = 23) or not associated (n = 66) with VHL disease. 40 (98%) hemangioblastomas expressed angptl4 whereas all pheochromocytomas (n = 23) and pancreatic tumors (n = 25) were angptl4-negative, whatever their VHL status. CONCLUSIONS/SIGNIFICANCE: Angptl4 mRNA expression was highly associated with ccRCC (p = 1.5 10(-49), Chi square test) allowing to define its expression as a diagnosis marker for primary ccRCC. Moreover, angptl4 mRNA allows to discriminate the renal origin of metastases of clear-cell carcinomas arising from various organs. Finally, inactivation of VHL gene is neither necessary nor sufficient for angptl4 mRNA induction.

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Fichiers liés : journal.pone.0010421.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2010
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2010
• Auteurs : Philippe Martin
• Organismes : Religions et croyances

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Chuixiang YiDaniel RicciutoRunze LiJohn WolbeckXiyan ZuMats NilssonLuis AiresJohn D. AlbertsonChristof AmmannAltaf ArainAlessandro de AraujoMarc AubinetMika AurelaZoltan BarczaAlan BarrPaul BerbigierJason BeringerChristian BernhoferAndrew BlackPaul BolstadFred BosveldMark BroadmeadowNina BuchmannSean BurnsPierre CellierJingming ChenJiquan ChenPhilippe CiaisRobert ClementBruce CookPeter CurtisBryan DailEbba DellwikNicolas DelpierreAnkur DesaiSabina DoreDanilo DragoniBert DrakeEric DufrêneAllison DunnJan ElbersWerner EugsterMatthias FalkChristian FeigenwinterLawrence FlanaganThomas FokenJohn FrankJuerg FuhrerDamiano GianelleAllen GoldsteinMike GouldenAndré GranierThomas GrünwaldLianhong GuHaiqiang HuoAlbin HammerleShijie HanNiall HananLászló HaszpraBernard HeineschCarole HelfterDimmie HendriksLindsay HutleyAndreas IbromCor JacobsTorbjörn JohanssonMarjan JongenGabriel KatulGerard KielyKatja KlumppAlexander KnohlThomas KolbWerner KutschPeter LafleurTuomas LaurilaRay LeuningAnders LindrothHeping LiuBenjamin LoubetGiovanni MancaMichal MarekHank MargolisTimothy MartinWilliam MassmanRoser MatamalaGiorgio MatteucciHarry MccaugheyLutz MerboldTilden MeyersMirco MigliavaccaFranco MigliettaLaurent MissonMeelis MölderJohn MoncrieffRussell K. MonsonLeonardo MontagnaniMario Montes-HeluEddy MoorsChristine MoureauxMukufute M. MukelabaiJ. William MungerMay MyklebustZoltán NagyAsko NoormetsWalter OechelRam OrenStephen G. PallardyKiaw Tha Paw UJoão S PereiraKim PilegaardKrisztina PintérCasimiro PioGabriel PitaThomas L. PowellSerge RambalJames T. RandersonCelso von RandowCorinna RebmannJanne RinneFederica RossiNigel RouletRonald J. RyelJorgen SagerforsNobuko SaigusaMaria José SanzGiuseppe-Scarascia MugnozzaHans Peter SchmidGuenther SeufertMario SiqueiraJean-François SoussanaGregory StarrMark A. SuttonJohn TenhunenZoltan TubaJuha-Pekka TuovinenRiccardo ValentiniChristoph S. VogelJingxin WangShaoqiang WangWeiguo WangLisa R. WelpXuefa WenSonia WhartonMatthew WilkinsonChristopher A. WilliamsGeorg WohlfartSusumu YamamotoGuiri YuRoberto ZampedriBin ZhaoXinquan Zhao
• Organismes : School of Earth and Environmental Sciences, Queens College Environmental Sciences Division [Oak Ridge] Department of Statistics School of Earth and Environmental Sciences, Queens College School of Earth and Environmental Sciences, Queens College Department of Forest Ecology and Management Centro de Estudos do Ambiente e do Mar = Centre for Environmental and Marine Studies [Aveiro] Department of Civil and Environmental Engineering Agroscope School of Geography and Earth Sciences [Hamilton ON] Instituto Nacional de Pesquisas da Amazônia = National Institute of Amazonian Research Gembloux Agro-Bio Tech, Unit of Biosystem Physics Climate and Global Change Research [Helsinki] Department of Meteorology [Budapest] Environment and Climate Change Canada Écologie fonctionnelle et physique de l'environnement School of Geography and Environmental Science Institute of Hydrology and Meteorology [Dresden] Land and Food Systems University of Minnesota [Twin Cities] Royal Netherlands Meteorological Institute Forest Research Institute of Plant Science National Center for Atmospheric Research [Boulder] Environnement et Grandes Cultures Department of Geography Department of Environmental Sciences [Toledo USA] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC School of Geosciences [Edinburgh] Biospheric Sciences Laboratory Department of Evolution, Ecology, and Organismal Biology Department of Plant, Soil, and Environmental Science Wind Energy Division [Roskilde] Commissariat à l'énergie atomique et aux énergies alternatives Department of Atmospheric and Oceanic Sciences [Madison] School of Forestry [Flagstaff] Atmospheric Science Program, Department of Geography Smithsonian Environmental Research Center Ecologie Systématique et Evolution Department of Physical and Earth Science Wageningen University and Research [Wageningen] Institute of Plant Science Department of Land, Air and Water Resources Institute for Meteorology, Climatology and Remote Sensing [Basel] Department of Biological Sciences Micrometeorology Group [Bayreuth] Rocky Mountain Research Station Agroscope Environment and Natural Resources Area Department of Environmental Science, Policy, and Management [Berkeley] Department of Earth System Science [Irvine] Ecologie et Ecophysiologie Forestières [devient SILVA en 2018] Institute of Hydrology and Meteorology [Dresden] Environmental Sciences Division [Oak Ridge] Key Laboratory for Biodiversity Science and Ecological Engineering [Shanghai] Institute of Ecology Institute of Applied Ecology Natural Resource Ecology Laboratory [Fort Collins] Hungarian Meteorological Service Gembloux Agro-Bio Tech, Unit of Biosystem Physics Centre for Ecology and Hydrology Department of Hydrology and Geo-Environmental Sciences [Amsterdam] School of Environmental and Life Sciences Biosystems Division [Roskilde] Earth System Science and Climate Change Group Geobiosphere Science Centre, Physical Geography and Ecosystems Analysis Instituto Superior de Agronomia [Lisboa] School of the Environment Civil and Environmental Engineering Department Unité de recherche sur l'Ecosystème Prairial Institute of Plant Science School of Forestry [Flagstaff] Institut für Agrarrelevante Klimaforschung Department of Geography Finnish Meteorological Institute CSIRO Marine and Atmospheric Research Geobiosphere Science Centre, Physical Geography and Ecosystems Analysis Department of Physics, Atmospheric Sciences and Geoscience [Jackson] Environnement et Grandes Cultures Institute of Atmospheric Pollution Research Division of Ecosystems Processes Lab. of Plants Ecological Physiology Centre d'études de la forêt Faculté de Foresterie et de Géomatique University of Florida [Gainesville] Rocky Mountain Research Station Biosciences Division National Research Council of Italy | Consiglio Nazionale delle Ricerche Department of Geography Max Planck Institute for Biogeochemistry ARL Atmospheric Turbulence and Diffusion Division Remote Sensing of Environmental Dynamics Laboratory, DISAT Instituto di Biometeorologia Centre d’Ecologie Fonctionnelle et Evolutive Geobiosphere Science Centre, Physical Geography and Ecosystems Analysis School of Geosciences [Edinburgh] Department of Ecology and Evolutionary Biology Servizi Forestali, Agenzia per l'Ambiente Faculty of Sciences and Technologies School of Forestry [Flagstaff] Wageningen University and Research [Wageningen] Gembloux Agro-Bio Tech, Unit of Biosystem Physics Gembloux Agro-Bio Tech, Unit of Crops Management Zambia Meteorological Department Department of Earth and Planetary Sciences [Cambridge, USA] CSIRO Marine and Atmospheric Research Institute of Botany and Ecophysiology Department of Forestry and Environmental Resources Department of Biology [San Diego State Univ] Nicholas School of the Environment and Earth Sciences Department of Forestry Atmospheric Science Group, LAWR Instituto Superior de Agronomia [Lisboa] Biosystems Division [Roskilde] Institute of Botany and Ecophysiology Centro de Estudos do Ambiente e do Mar = Centre for Environmental and Marine Studies [Aveiro] Mechanical Engineering Department The Department of Organismic and Evolutionary Biology Centre d’Ecologie Fonctionnelle et Evolutive Department of Earth System Science [Irvine] Earth System Science Center Department of Geography Department of Physics Instituto di Biometeorologia Department of Geography [Montréal] Department of Wildland Resources Department of Forest Ecology and Management Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research Centro de Estudios Ambientales del Mediterraneo Department of Agronomy, Forestry and Land Use Institut für Meteorologie und Klimaforschung - Atmosphärische Umweltforschung JRC Institute for Environment and Sustainability Nicholas School of the Environment and Earth Sciences Collège de Direction Department of Biological Sciences Centre for Ecology & Hydrology - Bush Estate Department of Plant Ecology Institute of Botany and Ecophysiology Climate and Global Change Research [Helsinki] Department of Forest Environment and Resources Biological Station chine Institute of Geographic Sciences and Natural Resource Research IMSG@National Center for Environmental Predictions Geosciences Research Division, Scripps Institution of Oceanography Institute of Geographic Sciences and Natural Resource Research Atmospheric, Earth and Energy Division Forest Research Graduate Degree Program in Geography Institute of Ecology Okayama University Institute of Geographic Sciences and Natural Resource Research Environment and Natural Resources Area Key Laboratory for Biodiversity Science and Ecological Engineering [Shanghai] Northwest Plateau Institute of Biology
• Publié dans Environmental Research Letters le 28/10/2020

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Résumé : Understanding the relationships between climate and carbon exchange by terrestrial ecosystems is critical to predict future levels of atmospheric carbon dioxide because of the potential accelerating effects of positive climate–carbon cycle feedbacks. However, directly observed relationships between climate and terrestrial CO2 exchange with the atmosphere across biomes and continents are lacking. Here we present data describing the relationships between net ecosystem exchange of carbon (NEE) and climate factors as measured using the eddy covariance method at 125 unique sites in various ecosystems over six continents with a total of 559 site-years. We find that NEE observed at eddy covariance sites is (1) a strong function of mean annual temperature at mid- and high-latitudes, (2) a strong function of dryness at mid- and low-latitudes, and (3) a function of both temperature and dryness around the mid-latitudinal belt (45°N). The sensitivity of NEE to mean annual temperature breaks down at ~ 16 °C (a threshold value of mean annual temperature), above which no further increase of CO2 uptake with temperature was observed and dryness influence overrules temperature influence.

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Fichiers liés : 2010_Yi_Envrionmental Research Letters_1.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2010
• Auteurs : Jean-Christophe PagèsJean-Jacques LeguayYves BertheauPascal BoireauDenis BourguetFlorence CoignardFrançois ColénoJean-Luc DarlixElie DassaMaryse DeguergueHubert De VerneuilRobert DrillienAnne Dubart-KupperchmittNicolas FerryClaudine FranchePhilippe GuercheJoël GuillemainMireille JacquemondAndré JestinBernard KlonjkowskiMarc LavielleJane LecomteOlivier Le GallStéphane LemariéDidier LereclusRémy MaximilienAntoine MesséanBertrand NeyJacques PagèsDaniel ParzyCatherine Regnault-RogerPierre RougéPatrick SaindrenanPascal SimonetVirginie TournayBernard E. VaissièreJean-Luc Vilotte
• Organismes : Institut Jean-Pierre Bourgin

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Résumé : Paris, le 14 octobre 2010 A V I S en réponse à la saisine 1 091201-saisine HCB-info compl oeillets concernant notamment le dossier C/NL/09/01. Le Haut Conseil des biotechnologies (HCB) a été saisi le 5 décembre 2009 par les autorités compétentes françaises (le Ministère de l'alimentation, de l'agriculture et de la pêche) d'une demande d'avis relative à une évaluation du dossier C/NL/09/01 de demande d'importation d'oeillets sous forme de fleurs coupées à des fins ornementales. Ce dossier a été déposé par la société Florigene Pty Limited dans le cadre de la directive 2001/18/CE auprès des autorités compétentes hollandaises, sous la référence C/NL/09/01. La saisine du HCB correspondante est référencée 091221-saisine HCB-info compl oeillets. Le Comité scientifique (CS) 2 du HCB a procédé à l'examen du dossier le 3 septembre 2010 sous la présidence de Jean-Christophe Pagès. 1 La saisine « 091221-saisine HCB-info compl oeillets » est reproduite dans l'Annexe 1. 2 La composition du CS ainsi que le rapporteur externe ayant contribué à l'élaboration de l'avis sont indiqués dans l'Annexe 2.

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Fichiers liés : 101026oeilletc-nl-09-01aviscshcb.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Natacha Entz-WerléPhilippe ChoquetAgnès NeuvilleSabine Kuchler-BoppFrançois ClaussJean-Marc DansePauline Simo-NoumbissieEric GuérinMarie-Pierre GaubJean-Noël FreundNelly BoehmAndré ConstantinescoPatrick LutzDominique GuenotFabienne Perrin-Schmitt
• Organismes : Service de Biophysique et Médecine Nucléaire Institut de Mécanique des Fluides et des Solides De l'homéostasie tissulaire au cancer et à l'inflammation Service de Biophysique et Médecine Nucléaire Service de Biophysique et Médecine Nucléaire Institut de Mécanique des Fluides et des Solides
• Publié dans Translational Oncology le 28/10/2020

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Résumé : TWIST and adenomatosis polyposis coli (APC) are critical signaling factors in normal bone development. In previous studies examining a homogeneously treated cohort of pediatric osteosarcoma patients, we reported the frequent and concurrent loss of both TWIST and APC genes. On these bases, we created a related animal model to further explore the oncogenic cooperation between these two genes. We performed intercrosses between twist-null/+ and Apc1638N/+ mice and studied their progeny. The Apc1638N/+; twist-null/+ mice developed bone abnormalities observed by macroscopic skeletal analyses and in vivo imaging. Complementary histologic, cellular, and molecular analyses were used to characterize the identified bone tumors, including cell culture and immunofluorescence of bone differentiation markers. Spontaneous localized malignant bone tumors were frequently identified in Apc1638N/+; twist-null/+ mice by in vivo imaging evaluation and histologic analyses. These tumors possessed several features similar to those observed in human localized osteosarcomas. In particular, the murine tumors presented with fibroblastic, chondroblastic, and osteoblastic osteosarcoma histologies, as well as mixtures of these subtypes. In addition, cellular analyses and bone differentiation markers detected by immunofluorescence on tumor sections reproduced most murine and human osteosarcoma characteristics. For example, the early bone differentiation marker Runx2, interacting physically with hypophosphorylated pRb, was undetectable in these murine osteosarcomas, whereas phosphorylated retinoblastoma was abundant in the osteoblastic and chondroblastic tumor subtypes. These characteristics, similar to those observed in human osteosarcomas, indicated that our animal model may be a powerful tool to further understand the development of localized osteosarcoma.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2010
• Auteurs : Pierre DériozPhilippe BéringuierAnne-Elisabeth Laques
• Organismes : UMR 228 Espace-Dev, Espace pour le développement Géographie de l'environnement UMR 228 Espace-Dev, Espace pour le développement
• Publié dans Développement durable et territoires le 24/10/2020

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Résumé : Dans le contexte d'un besoin d'observation généralisé du territoire, le double recours au paysage, en tant que source d'information et vecteur de participation, recouvre diverses modalités dont les limites tiennent à des contraintes techniques et politiques. Après une mise en perspective de l'approche centrée sur l'objet paysage de la plupart des observatoires photographiques du paysage, qui contribue parfois à la mobilisation des acteurs locaux mais sous-utilise généralement le potentiel informatif du paysage, cette contribution rend compte de deux démarches d'observation du territoire qui confèrent au paysage un statut central, en tant qu'outil d'observation et en tant que source d'information privilégiée, la première dans le PNR du Haut-Languedoc (réalisation d'un diagnostic territorial préalable à la révision de la charte du Parc, 2004-2008), la seconde, encore en phase de démarrage, en Amazonie Brésilienne (Haut-Solimoes), où l'association approche paysagère et images de satellite devrait palier les carences locales en information et fournir à terme des données spatialisées en matière d'usage des sols, de bio et d'agrodiversité

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Fichiers liés : mobiliser le paysage pour observer les territoires_quelles demarches pour quelle participation des acteurs_20101181528352101677894928414975187 beringuier.pdf

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