Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2009
• Auteurs : Maxine SunGiovanni LughezzaniClaudio JeldresHendrik IsbarnShahrokh F ShariatPhilippe ArjaneHugues WidmerDaniel PharandMathieu LatourPaul PerrotteJean-Jacques PatardPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Department of Urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit
• Publié dans European Urology le 23/10/2020

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Résumé : BACKGROUND: The conventional Fuhrman grading system, which categorizes renal cell carcinoma (RCC) with grades I, II, III, and IV, is the most widely used predictor assessment of RCC cancer-specific mortality (CSM). OBJECTIVES: The aim of this study was to test the prognostic ability of simplified Fuhrman grading schemes (FGSs) that rely on two- or three-tiered classifications. DESIGN, SETTING, AND PARTICIPANTS: The current study addressed a population of 14064 patients with clear cell RCC who were treated with partial or radical nephrectomy between 1988-2004, within nine Surveillance, Epidemiology, and End Results (SEER) cancer registries. MEASUREMENTS: Univariable and multivariable analyses as well as prognostic accuracy analyses were performed for various FGSs to test their ability to predict CSM rates. The conventional four-tiered FGS was compared to a modified two-tiered FGS in which grades I and II and grades III and IV were combined. A second simplified three-tiered FGS in which grades I and II were combined but grades III and IV were kept separate was also tested. RESULTS AND LIMITATIONS: The overall 5-yr CSM-free rate was 81.5%. All three FGSs achieved independent predictor status in multivariable analyses. Prognostic accuracy of multivariable models that relied on various FGSs was 83.6% for the modified two-tiered FGS and 83.8% for both the conventional four-tiered and the modified three-tiered FGS. CONCLUSIONS: Our findings indicate that the simplified FGSs perform equally as well as the conventional four-tiered FGS. The use of simplified grading schemes may represent an advantage for pathologists as well as for clinicians caring for patients with RCC.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2009
• Auteurs : Kamel MaoucheMyriam C. PoletteThomas JollyKahina MedjberIsabelle Cloëz-TayaraniJean-Pierre ChangeuxHenriette BurletChristine TerrynChristelle CorauxJean-Marie ZahmPhilippe L. BirembautJean-Marie Tournier
• Organismes : Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Département de Neuroscience - Department of Neuroscience Département de Neuroscience - Department of Neuroscience Collège de France Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques - UMR-S 903 Interactions cellules micro-environnement
• Publié dans American Journal of Pathology le 26/10/2020

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Résumé : Airway epithelial basal cells are known to be critical for regenerating injured epithelium and maintaining tissue homeostasis. Recent evidence suggests that the alpha7 nicotinic acetylcholine receptor (nAChR), which is highly permeable to Ca(2+), is involved in lung morphogenesis. Here, we have investigated the potential role of the alpha7 nAChR in the regulation of airway epithelial basal cell proliferation and the differentiation of the human airway epithelium. In vivo during fetal development and in vitro during the regeneration of the human airway epithelium, alpha7 nAChR expression coincides with epithelium differentiation. Inactivating alpha7 nAChR function in vitro increases cell proliferation during the initial steps of the epithelium regeneration, leading to epithelial alterations such as basal cell hyperplasia and squamous metaplasia, remodeling observed in many bronchopulmonary diseases. The regeneration of the airway epithelium after injury in alpha7(-/-) mice is delayed and characterized by a transient hyperplasia of basal cells. Moreover, 1-year-old alpha7(-/-) mice more frequently present basal cells hyperplasia. Modulating nAChR function or expression shows that only alpha7 nAChR, as opposed to heteropentameric alpha(x)beta(y) nAChRs, controls the proliferation of human airway epithelial basal cells. These findings suggest that alpha7 nAChR is a key regulator of the plasticity of the human airway epithelium by controlling basal cell proliferation and differentiation pathway and is involved in airway remodeling during bronchopulmonary diseases.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2009
• Auteurs : Guillaume LeurentClaire FougerouPierre-Yves PennecEmmanuelle FilippiBenoît MoquetPhilippe DruellesJean-Philippe HacotAntoine RialanGilles RouaultRenaud GervaisMarc BedossaDominique BoulmierBertrand BoulangerChristian HamonJosiane TreuilIsabelle CoudertHubert CourcouxHervé Le Breton
• Organismes : Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CIC-IT Rennes Laboratoire Traitement du Signal et de l'Image Centre d'Investigation Clinique [Rennes] Service de cardiologie [Brest] Service de cardiologie [Vannes] Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CIC-IT Rennes Laboratoire Traitement du Signal et de l'Image Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CIC-IT Rennes Laboratoire Traitement du Signal et de l'Image Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CIC-IT Rennes Laboratoire Traitement du Signal et de l'Image Service des urgences [Rennes] = Emergency [Rennes] Service des urgences [Rennes] = Emergency [Rennes] Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] CIC-IT Rennes Laboratoire Traitement du Signal et de l'Image
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : BACKGROUND: Minimizing delays to coronary reperfusion is critical in the management of acute myocardial infarction (AMI). AIMS: To determine delays in in-hospital management and factors associated with delays of over 45min. METHODS: We analysed data from the Observatoire Régional Breton sur l'Infarctus, a registry of AMI patients admitted within 24h of symptom onset (July 2007 to December 2008) to an interventional cardiology centre in Brittany. Prehospital delay was defined as time between first responder arrival at the patient and patient arrival at an interventional cardiovascular centre. In-hospital delay was defined as time between admission to the interventional cardiovascular centre and first balloon inflation. Patients were grouped according to duration of in-hospital delay (>45 vs

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• Type de publi. : Article dans une revue
• Date de publi. : 30/10/2009
• Auteurs : Isabelle JéruHasmik HayrapetyanPhilippe DuquesnoyEmmanuelle CochetJean-Louis SerreJosué FeingoldGilles GrateauTamara SarkisianMarc JeanpierreSerge Amselem
• Organismes : Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] National Academy of Sciences of the Republic of Armenia [Yerevan] Physiopathologie des maladies génétiques d'expression pédiatrique Physiopathologie des maladies génétiques d'expression pédiatrique Unité de pathologie cellulaire et génétique Physiopathologie des maladies génétiques d'expression pédiatrique Physiopathologie des maladies génétiques d'expression pédiatrique National Academy of Sciences of the Republic of Armenia [Yerevan] National Academy of Sciences of the Republic of Armenia [Yerevan] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Background: Identification of modifier genes and characterization of their effects represent major challenges in human genetics. SAA1 is one of the few modifiers identified in humans: this gene influences the risk of renal amyloidosis (RA) in patients with familial Mediterranean fever (FMF), a Mendelian autoinflammatory disorder associated with mutations in MEFV. Indeed, the SAA1 alpha homozygous genotype and the p.Met694Val homozygous genotype at the MEFV locus are two main risk factors for RA. Methodology/principal findings: HERE, WE INVESTIGATED ARMENIAN FMF PATIENTS AND CONTROLS FROM TWO NEIGHBORING COUNTRIES: Armenia, where RA is frequent (24%), and Karabakh, where RA is rare (2.5%). Sequencing of MEFV revealed similar frequencies of p.Met694Val homozygotes in the two groups of patients. However, a major deficit of SAA1 alpha homozygotes was found among Karabakhian patients (4%) as compared to Armenian patients (24%) (p = 5.10(-5)). Most importantly, we observed deviations from Hardy-Weinberg equilibrium (HWE) in the two groups of patients, and unexpectedly, in opposite directions, whereas, in the two control populations, genotype distributions at this locus were similar and complied with (HWE). Conclusions/significance: The excess of SAA1alpha homozygotes among Armenian patients could be explained by the recruitment of patients with severe phenotypes. In contrast, a population-based study revealed that the deficit of alpha/alpha among Karabakhian patients would result from a negative selection against carriers of this genotype. This study, which provides new insights into the role of SAA1 in the pathophysiology of FMF, represents the first example of deviations from HWE and selection involving the modifier gene of a Mendelian disorder.

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Fichiers liés : PlosOne2009Vol4_Jeru.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/10/2009
• Auteurs : Andreas WiklundSylvie GranonPhilippe FaureEva SundmanJean-Pierre ChangeuxLars I. Eriksson
• Organismes : Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital Department of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet Neurobiologie Intégrative des Systèmes Cholinergiques Neurobiologie Intégrative des Systèmes Cholinergiques Department of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital Collège de France Department of Physiology and Pharmacology, Section for Anaesthesiology and Intensive Care Medicine, Karolinska Institutet Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital
• Publié dans NeuroReport le 01/11/2020

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Résumé : Learning and memory are cognitive functions commonly impaired after surgery, especially in elderly patients. Our aim was to evaluate the effect of sevoflurane anaesthesia on episodic-like memory in young and aged wild-type mice and mice with altered nicotinic cholinergic neurotransmission (beta2KO). Mice learned objects before randomization to control, anaesthesia or sham groups. Anaesthesia was maintained at 2.6% sevoflurane for 2 h, starting immediately after training. Object memory testing was performed after 24 h, when one familiar object was replaced by a nonfamiliar object. While nonanaesthetized mice showed memory retention of the familiar object, anaesthetized wild-type and beta2KO mice showed impaired memory. Sevoflurane anaesthesia thus causes memory impairment in mice regardless of beta2 receptor-mediated nicotinic cholinergic neurotransmission.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/10/2009
• Auteurs : Cornelis van LeeuwenOlivier TregoatDavid PernetJean Philippe RobyCéline CelliéJean-Pierre J.-P. Gaudillere
• Organismes : Ecophysiologie et Génomique Fonctionnelle de la Vigne Viti Development Ecophysiologie et Génomique Fonctionnelle de la Vigne Chambre d'Agriculture de l'Hérault Œnologie

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Fichiers liés : COST858bookofabstract(1)_1.pdf

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• Type de publi. :
• Date de publi. : 26/10/2009
• Auteurs : Philippe ThalerFrédéric GayOlivier RoupsardYann NouvellonLaurent Saint‐andréAgnès de GrandcourtGuerric Le MaireJean-Marc J.-M. BonnefondJean-Pierre Bouillet
• Organismes : Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Centre de Coopération Internationale en Recherche Agronomique pour le Développement Écologie fonctionnelle et physique de l'environnement Centre de Coopération Internationale en Recherche Agronomique pour le Développement

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Fichiers liés : PROD20105a5427bd_20100727040405266_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 22/10/2009
• Auteurs : Nathalie Crevier-DenoixHenry ChateauD RobinPhilippe PourcelotSylvain FalalaLaurène HoldenBérangère Ravary-PlumioënPierre EstoupJean-Marie Denoix
• Organismes : Biomécanique et Pathologie Locomotrice du Cheval Biomécanique et Pathologie Locomotrice du Cheval Inconnu Biomécanique et Pathologie Locomotrice du Cheval Biomécanique et Pathologie Locomotrice du Cheval Biomécanique et Pathologie Locomotrice du Cheval Biomécanique et Pathologie Locomotrice du Cheval Inconnu Inconnu

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/10/2009
• Auteurs : Corinne LeyvalThierry BeguiristainPhilippe BertinCoralie BiacheAurélie CébronPierre FaureJean-Francois MasfaraudCécile CaupertStéphanie OuvrardMarie-Odile SimonnotPaule Vasseur
• Organismes : Laboratoire Interdisciplinaire des Environnements Continentaux Laboratoire Interdisciplinaire des Environnements Continentaux Centre National de la Recherche Scientifique Centre National de la Recherche Scientifique Centre National de la Recherche Scientifique Centre National de la Recherche Scientifique Université Paul Verlaine - Metz Centre National de la Recherche Scientifique Laboratoire Sols et Environnement Laboratoire Réactions et Génie des Procédés Université Paul Verlaine - Metz

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• Type de publi. : Communication dans un congrès
• Date de publi. : 19/10/2009
• Auteurs : Damien GarrotChristophe VoisinJean‐sébastien LauretCyrielle RoqueletThierry MichelValérie Alain-RizzoJacques A. DelairePhilippe RoussignolEmmanuelle Deleporte
• Organismes : Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire Laboratoire de Photonique Quantique et Moléculaire Laboratoire Pierre Aigrain Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire de Photophysique et Photochimie Supramoléculaires et Macromoléculaires Laboratoire Pierre Aigrain Laboratoire de Photonique Quantique et Moléculaire

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