Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Philippe ReiffsteckJean Pierre MagnanAbdeldjalil ZadjaouiAbdelmalek Bekkouche
• Organismes : Division Mécanique des Sols des Roches et de la Géologie de l'Ingénieur Direction technique "Géotechnique" Laboratoire Eau et Ouvrages dans Leurs Environnements Laboratoire Eau et Ouvrages dans Leurs Environnements
• Publié dans European Journal of Environmental and Civil Engineering le 29/10/2020

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Résumé : Cet article présente une étude en laboratoire de l'infiltration dans une colonne du sol initialement non saturé. Considérant certaines hypothèses simplificatrices, le phénomène du transfert hydrique est ramené physiquement à un processus décrit par une équation aux dérivées partielles type parabolique détaillée dans un premier temps. Dans un second temps l'article décrit le matériau utilisé dans cette étude. Il donne une description de montage utilisé pour suivre l'infiltration. Les courbes d'infiltration cumulée sont analysées en détail. Les auteurs montrent comment la conductivité hydraulique peut être déduite de ces mesures. L'application aux résultats du modèle de Philip montre une bonne concordance avec les mesures. Enfin, les conditions d'application et les interprétations sont détaillées.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Maxime CrépelHendrik IsbarnUmberto CapitanioDaniel LibermanClaudio JeldresMaxine SunShahrokh F ShariatHugues WidmerPhilippe ArjaneMarkus GraefenFrancesco MontorsiJean-Jacques PatardPaul PerrottePierre I. Karakiewicz
• Organismes : Service d'urologie [Rennes] = Urology [Rennes] Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Martini-Clinic Cancer Prognostics and Health Outcome Unit Department of Urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Division of Urology Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Martini-Clinic Department of urology Service d'urologie [Rennes] = Urology [Rennes] Institut de Génétique et Développement de Rennes Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit
• Publié dans Urology le 26/10/2020

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Résumé : OBJECTIVES: To test whether renal cell carcinoma (RCC) histologic subtypes (HSs) affect cancer-specific mortality after nephron-sparing surgery (NSS). HSs are considered of prognostic value in RCC. For example, the papillary HS might confer a worse prognosis, and, at some centers, only radical nephrectomy is performed for the papillary HS. METHODS: We used univariate and multivariate Cox regression models to study patients with Stage T1N0M0 RCC treated with NSS (n = 1205) from 1988 to 2004. The data were taken from 9 Surveillance, Epidemiology, and End Results registries. RESULTS: At 36 months after NSS, the cancer-specific mortality rate was 97.8%, 100%, and 97.4% for a clear cell, chromophobe, and papillary RCC HS, respectively. On univariate and multivariate analyses, no statistically significant differences were recorded with regard to the HS. CONCLUSIONS: Despite the suggested more aggressive phenotype of the papillary HS, we found no difference among the papillary, chromophobe, and clear cell variants. Thus, the diagnosis of one HS vs another HS should not deter from the use of NSS when cancer-specific mortality is considered as an endpoint.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Jean-Charles PreiserPhilippe DevosSergio Ruiz-SantanaChristian MélotDjillali AnnaneJohan GroeneveldGaetano IapichinoXavier Maurice LeverveGérard NitenbergPierre SingerJan WernermanMichael JoannidisAdela StecherRené Chioléro
• Organismes : Department of General Intensive Care Department of General Intensive Care Department of Intensive Care Department of Intensive Care Service de Réanimation Intensive Care Medicine Unit Department of Anaesthesia and Intensive Care Clinique de réanimation médicale Laboratoire de bioénergétique fondamentale et appliquée Département d'anesthésie, réanimation et pathologie infectieuse General Intensive Care Department and Institute for Nutrition Research Department of Anesthesiology and Intensive Care Medicine Department of Intensive Care Department of Anaesthesia and Intensive Care Service de médecine intensive adulte
• Publié dans Intensive Care Medicine le 27/10/2020

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Résumé : PURPOSE: An optimal target for glucose control in ICU patients remains unclear. This prospective randomized controlled trial compared the effects on ICU mortality of intensive insulin therapy (IIT) with an intermediate glucose control. METHODS: Adult patients admitted to the 21 participating medico-surgical ICUs were randomized to group 1 (target BG 7.8-10.0 mmol/L) or to group 2 (target BG 4.4-6.1 mmol/L). RESULTS: While the required sample size was 1,750 per group, the trial was stopped early due to a high rate of unintended protocol violations. From 1,101 admissions, the outcomes of 542 patients assigned to group 1 and 536 of group 2 were analysed. The groups were well balanced. BG levels averaged in group 1 8.0 mmol/L (IQR 7.1-9.0) (median of all values) and 7.7 mmol/L (IQR 6.7-8.8) (median of morning BG) versus 6.5 mmol/L (IQR 6.0-7.2) and 6.1 mmol/L (IQR 5.5-6.8) for group 2 (p < 0.0001 for both comparisons). The percentage of patients treated with insulin averaged 66.2 and 96.3%, respectively. Proportion of time spent in target BG was similar, averaging 39.5% and 45.1% (median (IQR) 34.3 (18.5-50.0) and 39.3 (26.2-53.6)%) in the groups 1 and 2, respectively. The rate of hypoglycaemia was higher in the group 2 (8.7%) than in group 1 (2.7%, p < 0.0001). ICU mortality was similar in the two groups (15.3 vs. 17.2%). CONCLUSIONS: In this prematurely stopped and therefore underpowered study, there was a lack of clinical benefit of intensive insulin therapy (target 4.4-6.1 mmol/L), associated with an increased incidence of hypoglycaemia, as compared to a 7.8-10.0 mmol/L target. (ClinicalTrials.gov # NCT00107601, EUDRA-CT Number: 200400391440).

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Fichiers liés : Preiser-IntCareMed-2009.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/10/2009
• Auteurs : Jean-Philippe DubusChristophe GonzalesPatrice Perny
• Organismes : DECISION DECISION DECISION

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Résumé : This paper is devoted to preference-based recommendation or configuration in the context of multiagent (or multicriteria) decision making. More precisely, we study the use of decomposable utility functions in the search for Choquet-optimal solutions on combinatorial domains. We consider problems where the alternatives (feasible solutions) are represented as elements of a product set of finite domains and evaluated according to different points of view (agents or criteria) leading to different objectives. Assuming that objectives take the form of GAI-utility functions over attributes, we investigate the use of GAI networks to determine efficiently an element maximizing an overall utility function defined by a Choquet integral.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Christelle DufourJosette CadusseauPascale VarletAnne-Laure SurenaGiselle P de FariaAmelie Dias-MoraisNathalie AugerNadine LéonardEstelle DaudigeosCarmela Dantas-BarbosaJacques GrillVladimir LazarPhilippe DessenGilles VassalVincent PrévotAriane SharifHerve ChneiweissMarie-Pierre Junier
• Organismes : Centre de Psychiatrie et Neurosciences Institut Mondor de Recherche Biomédicale Centre de Psychiatrie et Neurosciences Department of neuropathology Centre de Psychiatrie et Neurosciences Centre de Psychiatrie et Neurosciences Centre de Psychiatrie et Neurosciences Département de biologie et pathologie médicales [Gustave Roussy] Centre de Psychiatrie et Neurosciences Department of neuropathology Pharmacologie et nouveaux traitements des cancers Pharmacologie et nouveaux traitements des cancers Pharmacologie et nouveaux traitements des cancers Génomes et cancer Génomes et cancer Pharmacologie et nouveaux traitements des cancers Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre de Psychiatrie et Neurosciences Centre de Psychiatrie et Neurosciences Department of neuropathology
• Publié dans Stem Cells / Stem Cells (Miamisburg) le 31/10/2020

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Résumé : Gliomas, the most frequent primitive central nervous system tumors, have been suggested to originate from astrocytes or from neural progenitors/stem cells. However, the precise identity of the cells at the origin of gliomas remains a matter of debate because no pre-neoplastic state has been yet identified. Transforming growth factor (TGF)-alpha, an epidermal growth factor family member, is frequently overexpressed in the early stages of glioma progression. We previously demonstrated that prolonged exposure of astrocytes to TGF-alpha is sufficient to trigger their reversion to a neural progenitor-like state. To determine whether TGF-alpha dedifferentiating effects are associated with cancerous transforming effects, we grafted intracerebrally dedifferentiated astrocytes. We show that these cells had the same cytogenomic profile as astrocytes, survived in vivo, and did not give birth to tumors. When astrocytes dedifferentiated with TGF-alpha were submitted to oncogenic stress using gamma irradiation, they acquired cancerous properties: they were immortalized, showed cytogenomic abnormalities, and formed high-grade glioma-like tumors after brain grafting. In contrast, irradiation did not modify the lifespan of astrocytes cultivated in serum-free medium. Addition of TGF-alpha after irradiation did not promote their transformation but decreased their lifespan. These results demonstrate that reversion of mature astrocytes to an embryonic state without genomic manipulation is sufficient to sensitize them to oncogenic stress.

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Fichiers liés : inserm-00439883_edited.pdf s1-ln6124423-5903950401703867393Hwf-2076330358IdV15306111336124423FIRST_LOOK_PDF0001.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : Giovanni LughezzaniClaudio JeldresHendrik IsbarnPaul PerrotteShahrokh F. ShariatMaxine SunHugues WidmerPhilippe ArjaneFrancois PeloquinDaniel PharandJean-Jacques PatardMarkus GraefenFrancesco MontorsiPierre I. Karakiewicz
• Organismes : Cancer Prognostics and Health Outcome Unit Department of urology Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Martini-Clinic Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcome Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Cancer Prognostics and Health Outcomes Unit Service d'urologie [Rennes] = Urology [Rennes] Institut de Génétique et Développement de Rennes Martini-Clinic Department of urology Cancer Prognostics and Health Outcome Unit
• Publié dans The Journal of Urology le 27/10/2020

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Résumé : PURPOSE: A recent multi-institutional analysis of 995 patients treated for renal cell cancer questioned the relationship between tumor size and the synchronous metastasis rate. We revisited the hypothesis that metastatic potential is unrelated to tumor size. MATERIALS AND METHODS: We tested the relationship between tumor size and synchronous metastasis in 22,204 patients with T1a and T1b renal cell cancer diagnosed and/or treated with nephrectomy for clear cell, papillary or chromophobe histological subtypes in 1 of 9 Surveillance, Epidemiology and End Results registries between 1988 and 2004. RESULTS: In the study population the synchronous metastasis rate was 9.6%, including 5.6% vs 14.2% for T1a vs T1b. Stratification by 1 cm tumor size intervals revealed that the rate increased with increasing tumor size, that is 4.8% at 1.0 cm or less, 4.2% at 1.1 to 2.0 cm, 4.9% at 2.1 to 3.0 cm, 7.1% at 3.1 to 4.0 cm, 12.1% at 4.1 to 5.0 cm, 13.3% at 5.1 to 6.0 cm and 18.4% 6.1 to 7.0 cm (chi-square trend p <0.001). Cubic spline analysis showed that tumor size was virtually linearly related to the synchronous metastasis rate. Stratification by histological subtype in patients treated with nephrectomy revealed that clear cell renal cell cancer was most frequently associated with synchronous metastasis. Finally, tumor size was an independent predictor of synchronous metastasis in multivariate regression models adjusted for age, gender, histological subtype and year of diagnosis quartiles. CONCLUSIONS: Our study confirms that tumor size is an important determinant of the likelihood of synchronous metastasis in patients with T1a and T1b renal cell cancer. The synchronous metastasis rate directly increases with increasing tumor size. Even patients with small renal masses are at risk for synchronous metastasis and patients with clear cell renal cell cancer are at highest risk.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2009
• Auteurs : J. C. YeeA. UdalskiT. SumiSubo DongS. KozłowskiJ. C. BirdAndrew ColeD. HigginsJ. MccormickL. A. G. MonardD. PolishookA. ShporerO. SpectorM. K. SzymańskiM. KubiakGrzegorz PietrzyńskiI. SoszyńskiO. SzewczykK. UlaczykŁ. WyrzykowskiR. PoleskiW. AllenM. BosG. W. ChristieD. L. DepoyJ. D. EastmanB. S. GaudiA. GouldC. HanS. KaspiC.-U. LeeF. MalliaA. MauryD. MaozT. NatuschB.-G. ParkR. W. PoggeR. SantalloF. AbeI. A. BondA. FukuiK. FurusawaJ. B. HearnshawS. HosakaY. ItowK. KamiyaA. V. KorpelaP. M. KilmartinW. LinC. H. LingS. MakitaK. MasudaY. MatsubaraN. MiyakeY. MurakiM. NagayaK. NishimotoK. OhnishiY. C. PerrottN. J. RattenburyT. SakoTo. SaitoL. SkuljanD. J. SullivanW. L. SweatmanP. J. TristramP. C. M. YockM. D. AlbrowV. BatistaP. FouquéJean-Philippe BeaulieuD. P. BennettA. CassanJohan ComparatC. CouturesS. DietersJ. GreenhillK. HorneN. KainsD. KubasRoland MartinJ. MenziesJ. WambsganssAmy J. WilliamsM. Zub
• Organismes : The Ohio State University [Columbus] Laboratoire Astrophysique de Toulouse-Tarbes Institut d'Astrophysique de Paris Astronomische Rechen-Institut [Heidelberg]
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : We analyze the extreme high-magnification microlensing event OGLE-2008-BLG-279, which peaked at a maximum magnification of A ~ 1600 on 2008 May 30. The peak of this event exhibits both finite-source effects and terrestrial parallax, from which we determine the mass of the lens, Ml = 0.64 ± 0.10 M sun, and its distance, Dl = 4.0 ± 0.6 kpc. We rule out Jupiter-mass planetary companions to the lens star for projected separations in the range 0.5-20 AU. More generally, we find that this event was sensitive to planets with masses as small as 0.2 \;M_\oplus \simeq 2 \;M_{Mars} with projected separations near the Einstein ring (~3 AU).

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/09/2009
• Auteurs : Gaëlle LortalNathalie ChaignaudJean-Philippe KotowiczJean-Pierre Pécuchet
• Organismes : Thales Research and Technology [Palaiseau] Equipe Multi-agent, Interaction, Décision Equipe Multi-agent, Interaction, Décision Equipe Multi-agent, Interaction, Décision

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Résumé : The Semantic Web (SW) originally aims at studying a system interoperability based on a shared common knowledge base (ontology). Henceforth, the SW sets its heart on a semantic coordination of community parlance representative resources (in complement to a common knowledge base shared by the users). The matter is not only to use techniques to handle a large amount of data, but also to use approaches to keep the community parlance features. Thus, Web documents and folksonomies are the main semantic vehicle. They are little structured and Natural Language Processing (NLP) methods are then beneficial to analyze language specificities with a view to automating tasks about text. This paper describes a use of NLP techniques for the SW through a document engineering application: the information retrieval in a catalogue of online medical resources. Our approach emphasizes benefits of NLP techniques to handle multi-granular terminological resources.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/09/2009
• Auteurs : Cécile CourivaudJamal BamoulidPierre TiberghienPhilippe SaasJean-Marc ChalopinDidier DuclouxChristophe LegendreEric Thervet
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Service de néphrologie adultes [CHU Necker] Service de néphrologie adultes [CHU Necker]
• Publié dans Transplantation le 25/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 24/09/2009
• Auteurs : Joffrey MoirouxCecile Le LannMajeed A. SeyahooeiPhilippe VernonJean-Sébastien PierreJoan van BaarenJacques J.M. J.M. van Alphen
• Organismes : Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Institute Biology Leiden Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Ecosystèmes, biodiversité, évolution [Rennes] Paysages, Changements Climatique, Biodiversité

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