Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/09/2024
• Auteurs : Nicolas ChaizeXavier BaudryPierre-Henri JouneauEric GautierJean-Luc RouviereYves DeblockB. GrandidierL. DesplanqueHermann SellierPhilippe Ballet
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Modélisation et Exploration des Matériaux Modélisation et Exploration des Matériaux Laboratoire d'Etude des Matériaux par Microscopie Avancée Modélisation et Exploration des Matériaux Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Centrale de Micro Nano Fabrication - IEMN Physique - IEMN EPItaxie et PHYsique des hétérostructures - IEMN Nano-Electronique Quantique et Spectroscopie Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information

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• Type de publi. : Article dans une revue
• Date de publi. : 05/09/2024
• Auteurs : Marion FilliâtreSeda SerenAnge Embo-IbouangaJean-Patrick JolyVéronique BouchaudInes KelkoulSylvain MarqueGérard AudranPierre VoisinPhilippe Mellet
• Organismes : Institut de Chimie Radicalaire Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques Institut de Chimie Radicalaire Institut de Chimie Radicalaire Centre de résonance magnétique des systèmes biologiques Centre de résonance magnétique des systèmes biologiques
• Publié dans ACS Omega le 23/10/2020

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Fichiers liés : Filliâtre et al. - 2024 - Intrinsic Proteolytic Activities from Cancer Cells.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/09/2024
• Auteurs : Sélim Ben ChéhidaHeemee Devi BunwareeMurielle HoareauOumaima MoubsetCharlotte JulianLaurence BlondinDenis FillouxChristophe LavergnePhilippe RoumagnacArvind VarsaniDarren MartinJean Michel LettPierre Lefeuvre
• Organismes : Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Plant Health Institute of Montpellier Conservatoire Botanique National de Mascarin Plant Health Institute of Montpellier Arizona State University [Tempe] University of Cape Town University of Cape Town Peuplement Végétaux et Bioagresseurs en Milieu Tropical - Pôle de Protection des Plantes Peuplements végétaux et bioagresseurs en milieu tropical

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Résumé : The geographical distribution and diversity of viruses can differ between cultivated areas and adjacent natural environments, raising questions about the interplay between plant diversity and the species richness and prevalence of the phytoviruses. As both the amplification and the dilution of viral species richness due to increasing host diversity have been theorized and observed, a deeper understanding of how plant-viruses interact in natural environments is needed to explore how host availability conditions viral diversity and distributions. This study explores interactions of viruses from the Mastrevirus genus (family Geminiviridae) with hosts from the Poaceae family across ten sites from three contrasting ecosystems on La Réunion. Among 273 plant pools, representing 61 Poales species, 15 Mastrevirus species were characterized from 22 hosts. We find a strong association of mastreviruses with hosts from agro-ecosystems and the absence of mastreviruses in subalpine areas, dominated by native plants. This suggests that all detected mastreviruses likely originated from viruses introduced through agricultural activities rather than being native to La Réunion. Analyses of the structure of the host plant-mastrevirus interaction network revealed a pattern of increasing viral richness with increasing host richness. Accounting for variations in the diversity of hosts across sites, we observed increasing viral niche occupancies with increasing host species richness. Virus realized richness at any given site is conditioned on the global capacity of the plant populations to host diverse mastreviruses. Whether this tendency is driven by synergy between viruses, or by an interplay between vector population and plant richness, remains to be established.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 05/09/2024
• Auteurs : Dany JaffuelErika NoguéJean-Pierre MalletFrançois RoubilleSébastien BaillyFrançois GoupilThierry PigeanneCarole HervéPhilippe MassonAcya Bizieux-ThaminyMargaux BlanchardSandrine KerbratAbdelkebir SabilWojciech TrzepizurNicolas MolinariF. Gagnadoux
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Adène groupe Hôpital Arnaud de Villeneuve [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Adène groupe Hôpital Arnaud de Villeneuve [CHU Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Hypoxie et PhysioPathologie Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Cidelec DAMAD Plouzané Cloud Sleep Lab MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Centre Hospitalier Universitaire d'Angers Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Centre Hospitalier Universitaire d'Angers

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Résumé : Background: Whether PAP therapy adherence is associated with a reduction in oral antihypertensive drugs (OADs) burden remains unclear. Aims and objectives: This study aimed to assess the association between the adherence to PAP therapy and the delivery of OADs. Methods: Data from the IRSR Pays de la Loire Sleep Cohort were linked with the French health insurance database to identify OAD delivery in patients with prevalent hypertension at OSA diagnosis. OAD classification followed the 2023 international guidelines. The primary endpoint was the difference in the number of OAD classes at one year compared to baseline (mean delta OAD) in PAP-adherent patients (AP), defined as those with a median PAP use of ≥ 4 hours per day (h/d), versus PAP non-adherent patients (NAP), with PAP use < 4 h/d or PAP termination. Results: The analysis included 2205 patients (68.0% male) with a median age of 61 years (IQ1-Q3: 54-68), BMI of 32.4 kg/m2 (28.9-36.4), and initial AHI of 39/h (30-55). At OSA diagnosis, 33.6% were treated with 1 OAD, 32.8% with 2 OADs, 33.5% with 3 or more OADs. At one year follow up, 78.1% were AP (median PAP use 6.52 (5.52-7.76) h/d and 21.9% were NAP (PAP use 2.58 (1.41-3.34) h/d or PAP termination). Mean (SD) delta OAD was -0.02 (±0.58) and -0.04 (±0.7) in AP and NAP respectively (p=0.68). The number of OADs decreased by 11.1% and 13.5%, and increased by 10.5% and 12.1% in AP and NAP (p=0.11). Conclusions: In real-life settings, we found no association between adherence to PAP therapy of OSA and the number of OAD classes delivered at one year. Further subgroup analyses are ongoing.

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2024
• Auteurs : Hélène SeroussiTyler PelleW H LipscombAyako Abe‐ouchiTorsten AlbrechtJorge Alvarez-SolasXylar Asay-DavisJean‐baptiste BarreConstantijn J BerendsJorge BernalesJavier BlascoJustine CailletDavid ChandlerViolaine CoulonRichard CullatherChristophe DumasBenjamin K. Galton-FenziJulius GarbeF Gillet-ChauletRupert GladstoneHeiko GoelzerNicholas R. GolledgeRalf GreveG. Hilmar Hilmar GudmundssonHolly Kyeore HanTrevor HillebrandM. HoffmanP. HuybrechtsNicolas JourdainAnn Kristin KlosePetra LangebroekGunter LeguyDaniel LowryPierre MathiotMarisa MontoyaMathieu MorlighemSophie NowickiFrank PattynAntony PayneAurélien QuiquetRonja ReeseAlexander RobinsonLeopekka SarasteErika SimonS. SunJake TwarogLuke D TruselBenoît UrrutyJonas van BreedamR S W van de WalYu WangXinying ZhangThomas Zwinger
• Organismes : Dartmouth College [Hanover] University of California [San Diego] National Center for Atmospheric Research [Boulder] The University of Tokyo Leibniz Association = Leibniz Gemeinschaft = Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] Los Alamos National Laboratory University of California [Irvine] Universiteit Utrecht / Utrecht University [Utrecht] Universiteit Utrecht / Utrecht University [Utrecht] Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] Institut des Géosciences de l’Environnement Bjerknes Centre for Climate Research Université libre de Bruxelles = Free University of Brussels NASA Goddard Space Flight Center Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation du climat Australian Antarctic Division Leibniz Association = Leibniz Gemeinschaft = Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz Institut des Géosciences de l’Environnement University of Lapland Bjerknes Centre for Climate Research Victoria University of Wellington Hokkaido University [Sapporo, Japan] Northumbria University [Newcastle] Los Alamos National Laboratory Los Alamos National Laboratory Los Alamos National Laboratory Vrije Universiteit Brussel [Bruxelles] Institut des Géosciences de l’Environnement Leibniz Association = Leibniz Gemeinschaft = Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz Bjerknes Centre for Climate Research National Center for Atmospheric Research [Boulder] GNS Science [Lower Hutt] Institut des Géosciences de l’Environnement Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] Dartmouth College [Hanover] University at Buffalo [SUNY] Université libre de Bruxelles = Free University of Brussels University of Liverpool Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Leibniz Association = Leibniz Gemeinschaft = Wissenschaftsgemeinschaft Gottfried Wilhelm Leibniz Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] IT Center for Science [Espoo] NASA Goddard Space Flight Center Northumbria University [Newcastle] Dartmouth College [Hanover] Pennsylvania State University [State College, PA] Institut des Géosciences de l’Environnement Vrije Universiteit Brussel [Bruxelles] Universiteit Utrecht / Utrecht University [Utrecht] University of Tasmania [Hobart] University of Tasmania [Hobart] IT Center for Science [Espoo]
• Publié dans Earth's Future le 04/09/2017

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Résumé : The Ice Sheet Model Intercomparison Project for CMIP6 (ISMIP6) is the primary effort of CMIP6 (Coupled Model Intercomparison Project–Phase 6) focusing on ice sheets, designed to provide an ensemble of process‐based projections of the ice‐sheet contribution to sea‐level rise over the twenty‐first century. However, the behavior of the Antarctic Ice Sheet beyond 2100 remains largely unknown: several instability mechanisms can develop on longer time scales, potentially destabilizing large parts of Antarctica. Projections of Antarctic Ice Sheet evolution until 2300 are presented here, using an ensemble of 16 ice‐flow models and forcing from global climate models. Under high‐emission scenarios, the Antarctic sea‐level contribution is limited to less than 30 cm sea‐level equivalent (SLE) by 2100, but increases rapidly thereafter to reach up to 4.4 m SLE by 2300. Simulations including ice‐shelf collapse lead to an additional 1.1 m SLE on average by 2300, and can reach 6.9 m SLE. Widespread retreat is observed on that timescale in most West Antarctic basins, leading to a collapse of large sectors of West Antarctica by 2300 in 30%–40% of the ensemble. While the onset date of retreat varies among ice models, the rate of upstream propagation is highly consistent once retreat begins. Calculations of sea‐level contribution including water density corrections lead to an additional ∼10% sea level and up to 50% for contributions accounting for bedrock uplift in response to ice loading. Overall, these results highlight large sea‐level contributions from Antarctica and suggest that the choice of ice sheet model remains the leading source of uncertainty in multi‐century projections.

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Fichiers liés : Earth s Future - 2024 - Seroussi - Evolution of the Antarctic Ice Sheet Over the Next Three Centuries From an ISMIP6 Model.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2024
• Auteurs : Camille FletcherAlice HadchouelCaroline ThumerelleJulie MazenqManon FleuryHarriet CorvolNouha JedidiMyriam BenhamidaKatia BessaciTiphaine BilhoueeRaphaël BorieJacques BrouardAurélie CantaisAnnick ClementLaurianne CoutierCamille CisternePierrick CrosMarie-Laure DalphinChristophe DelacourtEric DeneuvilleJean-Christophe DubusCarole EgronRalph EpaudMichael FayonAude ForgeronElsa GachelinFrançois GalodeIsabelle GertiniLisa Giovannini-ChamiPierre GourdanTamazoust GuiddirAudrey HerzogVéronique HoudouinÉglantine HulloPierre-Henri JarreauGuillame LabbéGéraldine LabouretAlice LadauradeLaurence Le Clainche VialaChristophe MarguetAlexandra Masson-RouchaudCaroline PerissonCinthia RamesPhilippe ReixMarie-Catherine RenouxLéa RoditisCyril SchweitzerAurélie TatopoulosPascale Trioche-EberschweilerFrançoise TroussierClémentine VigierLaurence WeissMarie LegendreCamille LouvrierAlix de BecdelievreAurore CoulombChiara SileoHubert Ducou Le PointeLaureline BertelootCéline DelestrainNadia Nathan
• Organismes : CHU Trousseau [APHP] Assistance publique - Hôpitaux de Paris (AP-HP) Structure Fédérative de Recherche Necker Institut Necker Enfants-Malades Université de Lille Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research CHU Trousseau [APHP] Sorbonne Université Mucoviscidose: physiopathologie et phénogénomique [CRSA] CHU Trousseau [APHP] Centre de Recherche Saint-Antoine CHU Trousseau [APHP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital AP-HP - Hôpital Bichat - Claude Bernard [Paris] Physiopathologie et Epidémiologie des Maladies Respiratoires CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Groupe de Recherche sur l'Adaptation Microbienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] CHU Trousseau [APHP] Hospices Civils de Lyon Integrated Physiology of the Brain Arousal Systems CHRU de Brest - Département de Pédiatrie Centre Hospitalier Régional Universitaire de Besançon Hôpital Sud [CHU Rennes] Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Microbes Evolution Phylogénie et Infections
• Publié dans Thorax le 22/10/2020

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Résumé : Introduction Interstitial lung disease in children (chILD) are rare and mostly severe lung diseases. Very few epidemiological data are available in limited series of patients. The aim of this study was to assess the prevalence and incidence of chILD in France. Methods We performed within the RespiRare network a multicentre retrospective observational study in patients with chILD from 2000 to 2022 and a prospective evaluation of chILD’s incidence between February 2022 and 2023. Results chILD was reported in 790 patients in 42 centres. The estimated 2022 prevalence in France was 44 /million children (95% CI 40.76 to 47.46) and the computed incidence was 4.4 /million children (95% CI 3.44 to 5.56). The median age at diagnosis was 3 months with 16.9% of familial forms. Lung biopsy and genetic analyses were performed in 23.4% and 76.9%, respectively. The most frequent chILD aetiologies in the <2 years group were surfactant metabolism disorders (16.3%) and neuroendocrine cell hyperplasia of infancy (11.8%), and in the 2–18 years group diffuse alveolar haemorrhage (12.2%), connective tissue diseases (11.4%), hypersensitivity pneumonitis (8.8%) and sarcoidosis (8.8%). The management included mainly oxygen therapy (52%), corticosteroid pulses (56%), oral corticosteroids (44%), azithromycin (27.2%), enteral nutrition (26.9%), immunosuppressants (20.3%) and hydroxychloroquine (15.9%). The 5-year survival rate was 57.3% for the patients diagnosed before 2 years and 86% between 2 and 18 years. Conclusion This large and systematic epidemiological study confirms a higher incidence and prevalence of chILD than previously described. In order to develop international studies, efforts are still needed to optimise the case collection and to harmonise diagnostic and management practices.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/09/2024
• Auteurs : Louise TarradeJean-Pierre ChevrotJean-Philippe Magué
• Organismes : Interactions, Corpus, Apprentissages, Représentations LInguistique et DIdactique des Langues Étrangères et Maternelles Institut Rhône-Alpin des systèmes complexes Interactions, Corpus, Apprentissages, Représentations
• Publié dans PLOS Complex Systems le 07/01/2025

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Résumé : How position in the network determines the fate of lexical innovations on Twitter Louise Tarrade1*, Jean-Pierre ChevrotID1,2*, Jean-Philippe Mague´ ID1,3 1 ICAR laboratory (UMR 5191), E´ cole Normale Supe´rieure de Lyon, France, 2 LIDILEM laboratory (EA 609), Universite´ Grenoble Alpes, France, 3 IXXI, Complex Systems Institute, Lyon, France * louise.tarrade@ens-lyon.fr (LT); jean-pierre.chevrot@univ-grenoble-alpes.fr (J-PC) Abstract This study analyzes the diffusion of lexical innovations on Twitter to understand how the social network position of adopters impacts their success. Looking at both successful and failed neologisms, we categorize them into "changes" which become established and "buzzes" which decline over time. Using a corpus of 650 million French tweets, we recon- struct user networks and characterize adopters of innovations during different diffusion phases based on prestige, centrality, clustering, and external ties. In the early innovation phase, change and buzz adopters have similar peripheral profiles. During propagation, changes spread to prestigious, central individuals while buzzes do not, which predicts their eventual success or failure. By the establishment phase, changes reach highly central users with closer external ties. The results align with sociolinguistic theories about weak ties for innovation and strong ties for establishment. Additionally, logistic regression models based on early adopter profiles can predict the fate of innovations. This work sheds light on the dif- fusion dynamics of online lexical innovations and the crucial role of user network factors.

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Fichiers liés : Journal PLoS 0000005.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 03/09/2024
• Auteurs : Philippe RicaudPierre DurandPaolo GrigioniMassimo del GuastaGiuseppe CamporealeAxel RoyJean-Luc AttiéJohn Bognar
• Organismes : Centre national de recherches météorologiques Laboratoire d'aérologie Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile = Italian National Agency for New Technologies, Energy and Sustainable Economic Development Istituto Nazionale di Ottica [Firenze] Istituto per il Rilevamento Elettromagnetico dell'Ambiente [Napoli] Centre national de recherches météorologiques Laboratoire d'aérologie Anasphere
• Publié dans Atmospheric Measurement Techniques le 24/10/2020

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Résumé : Clouds in Antarctica are key elements that affect radiative forcing and thus Antarctic climate evolution. Although the vast majority of clouds are composed of ice crystals, a non-negligible fraction constitutes supercooled liquid water (SLW; water held in liquid form below 0 °C). Numerical weather prediction models have great difficulty in forecasting SLW clouds over Antarctica, favouring ice at the expense of liquid water and therefore incorrectly estimating the cloud radiative forcing. Remote-sensing observations of SLW clouds have been carried out for several years at Concordia Station (75° S, 123° E; 3233 m above mean sea level), combining active lidar measurements (SLW cloud detection) and passive HAMSTRAD microwave measurements (liquid water path, LWP). The present project aimed at in situ observations of SLW clouds using sondes developed by the company Anasphere, specifically designed for SLW content (SLWC) measurements. These SLWC sondes were coupled to standard meteorological pressure–temperature–humidity sondes from Vaisala and released under meteorological balloons. During the 2021–2022 summer campaign, 15 launches were made, of which 7 were scientifically exploitable above a height of 400 m above ground level, a threshold height imposed by the time the SLWC sonde takes to stabilize after launch. The three main outcomes from our analyses are as follows: (a) the first in situ observations so far of SLW clouds in Antarctica with SLWC sondes; (b) on average, the consistency of SLW cloud heights as observed by in situ sondes and remote-sensing lidar; and (c) the liquid water path (vertically integrated SLWC) deduced by the sondes being generally equal to or greater than the LWP remotely sensed by HAMSTRAD. In general, the SLW clouds were observed in a layer close to saturation (U > 80 %) or saturated (U ∼ 100 %–105 %) just below or at the lowermost part of the entrainment zone, or capping inversion zone, which exists at the top of the planetary boundary layer and is characterized by an inflection point in the potential temperature vertical profile. Our results are consistent with the theoretical view that SLW clouds form and remain at the top of the planetary boundary layer.

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Fichiers liés : Ricaud_2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 02/09/2024
• Auteurs : Robin Le RuzLionel LerouxThibault LhermusierMarco ProiettiEric van BelleAlain DibiéVincenzo PalermoDidier ChampagnacJean-François ObadiaEmmanuel TeigerPatrick OhlmanDidier TchétchéHervé Le BretonChristophe Saint-EtiennePierre-Guillaume PiriouJulien PlessisSylvain BeurtheretFlorence Du ChaylaManon LeclèreThierry LefèvreJean-Philippe ColletHelene EltchaninoffMartine GilardBernard IungThibaut ManigoldVincent Letocart
• Organismes : ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Hôpital Haut-Lévêque [CHU Bordeaux] Service Cardiologie [CHU Toulouse] Aix Marseille Université Institut Pasteur de Lille Institut Mutualiste de Montsouris Hôpital Marie-Lannelongue Médipôle Lyon-Villeurbanne Hôpital Louis Pradel [CHU - HCL] Hospices Civils de Lyon Centre d'Investigation Clinique [Bron] Service de Cardiologie [CHU Henri Mondor] Université de Strasbourg Clinique Pasteur [Toulouse] Centre Hospitalier Universitaire [Rennes] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Régional Universitaire de Tours ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Hôpital Saint-Joseph [Marseille] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Hôpital Privé Jacques Cartier [Massy] CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Endothélium, valvulopathies et insuffisance cardiaque Hôpital de la Cavale Blanche - CHRU Brest Assistance publique - Hôpitaux de Paris (AP-HP) ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291
• Publié dans EuroIntervention le 28/10/2020

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Résumé : Background: Large datasets of transcatheter aortic valve implantation (TAVI) for pure aortic valve regurgitation (PAVR) are scarce. Aims: We aimed to report procedural safety and long-term clinical events (CE) in a contemporary cohort of PAVR patients treated with new-generation devices (NGD). Methods: Patients with grade III/IV PAVR enrolled in the FRANCE-TAVI Registry were selected. The primary safety endpoint was technical success (TS) according to Valve Academic Research Consortium 3 criteria. The co-primary endpoint was defined as a composite of mortality, heart failure hospitalisation and valve reintervention at last follow-up. Results: From 2015 to 2021, 227 individuals (64.3% males, median age 81.0 [interquartile range {IQR} 73.5-85.0] years, with EuroSCORE II 6.0% [IQR 4.0-10.9]) from 41 centres underwent TAVI with NGD, using either self-expanding (55.1%) or balloon-expandable valves (44.9%; p=0.50). TS was 85.5%, with a non-significant trend towards increased TS in high-volume activity centres. A second valve implantation (SVI) was needed in 8.8% of patients, independent of valve type (p=0.82). Device size was ≥29 mm in 73.0% of patients, post-procedure grade ≥III residual aortic regurgitation was rare (1.2%), and the permanent pacemaker implantation (PPI) rate was 36.0%. At 30 days, the incidences of mortality and reintervention were 8.4% and 3.5%, respectively. The co-primary endpoint reached 41.6% (IQR 34.4-49.6) at 1 year, increased up to 61.8% (IQR 52.4-71.2) at 4 years, and was independently predicted by TS, with a hazard ratio of 0.45 (95% confidence interval: 0.27-0.76); p=0.003. Conclusions: TAVI with NGD in PAVR patients is efficient and reasonably safe. Preventing the need for an SVI embodies the major technical challenge. Larger implanted valves may have limited this complication, outweighing the increased risk of PPI. Despite successful TAVI, PAVR patients experience frequent CE at long-term follow-up.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2024
• Auteurs : Jordan LabidiAude WarniezPhilippe DerambureThibaud LebouvierFlorence PasquierArnaud DelvalNacim Betrouni
• Organismes : Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Centre Mémoire de Ressources et de Recherche [Lille-Bailleul] Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837
• Publié dans Neurophysiologie Clinique = Clinical Neurophysiology le 01/11/2020

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Résumé : This study aimed to compare the diagnostic performance of visual assessment of electroencephalography (EEG) using the Grand Total EEG (GTE) score and quantitative EEG (QEEG) using spectral analysis in the context of cognitive impairment. This was a retrospective study of patients with mild cognitive impairment, with (MCI+V) or without (MCI) vascular dysfunction, and patients with dementia including Alzheimer's disease, Lewy Body Dementia and vascular dementia. The results showed that the GTE is a simple scoring system with some potential applications, but limited ability to distinguish between dementia subtypes, while spectral analysis appeared to be a powerful tool, but its clinical development requires the use of artificial intelligence tools.

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