Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 03/09/2009
• Auteurs : Maud LemoineVlad RatziuMin Ji KimMustapha MaachiDominique WendumFrançois PayeJean Philippe BastardRaoul PouponChantal HoussetJacqueline CapeauLawrence Serfaty
• Organismes : Pathologie de l'Adipocyte et des Cellules Hepatiques
• Publié dans Liver International le 25/10/2020

---

Résumé : Abstract Aims: The aim of this study was to determine whether serum levels of adipokines, including the ratio of serum adiponectin to leptin (A/L) levels could predict the severity of liver injury in patients with non‐alcoholic fatty liver disease (NAFLD). Patients and methods: Fifty‐seven patients with biopsy‐proven non‐alcoholic steatohepatitis (NASH) (mean age 51±12, sex ratio 1), 17 with simple steatosis (mean age 47±12, sex ratio 1.4) and 10 controls without steatosis (mean age 51±11, sex ratio 4) were investigated. In all subjects, serum concentrations of triglycerides, ultrasensitive C reactive protein, leptin, adiponectin, soluble tumour necrosis factor receptor 1, interleukin (IL)‐6 and Homeostasis Model Assessment Method (HOMA) were measured. Hepatic expression of adiponectin and its two receptors was assessed by quantitative reverse transcriptase polymerase chain reaction. Results: Body mass index (BMI) and HOMA were correlated positively with leptin levels ( r =0.44 and 0.28 respectively) and negatively with the A/L ratio ( r =0.51 and 0.41 respectively). Independent parameters associated with NASH vs steatosis were HOMA>3 [odds ratio (OR)=6.9] and A/L ratio <1.4 10 3 (OR=5.2). The combination of HOMA with A/L ratio showed an area under the receiver operating characteristic curve of 0.82 for distinguishing between NASH and steatosis. Extensive portal fibrosis was present in 17 (23%) patients with NAFLD. Three independent parameters were associated with fibrosis: age (OR=1.1), BMI (OR=1.3) and high IL‐6 levels (OR=1.6). The hepatic expression of adiponectin receptor 2 was significantly higher in patients with NASH compared with controls and was related with necroinflammatory injury. Conclusions: This study shows that in patients with NAFLD, the combination of HOMA with A/L ratio may be a useful non‐invasive approach to appreciate the severity of liver damage.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 02/09/2009
• Auteurs : Laurent LecornuGregoire ThillayClara Le GuillouPierre-Jean GarreauPhilippe SaliouHélène JantzemJohn PuentesJean Michel Cauvin
• Organismes : Département Image et Traitement Information Laboratoire de Traitement de l'Information Medicale Département Image et Traitement Information Laboratoire de Traitement de l'Information Medicale CHRU de Brest, Département information médicale CHRU de Brest, Département information médicale CHRU de Brest, Département information médicale CHRU de Brest, Département information médicale Département Image et Traitement Information CHRU de Brest, Département information médicale Laboratoire de Traitement de l'Information Medicale CHRU de Brest, Département information médicale

---

Résumé : Choosing diagnosis codes is a non-intuitive operation for the practitioner. Mistakes are frequent with severe consequences on healthcare evaluation and funding.French physicians have to assign a code for everything they do and they are not spared with these kinds of errors. We propose a tool named REFEROCOD to support the medical coding task in order to minimize errors without losing time, by suggesting a list of codes in accordance with the physician activities and of the patient medical context. The proposed method uses probabilistic knowledge and indicates the probability to have a proper diagnosis code considering the realized procedure, age, sex and other information available in the discharge abstract.

---

Fichiers liés : 2_REFEROCOD_2009.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 02/09/2009
• Auteurs : Adrien UgonCarole PhilippeJean-Gabriel GanasciaDominique RakotonanaharyHélène AmielJean-Yves BoirePierre P Lévy
• Organismes : Agents Cognitifs et Apprentissage Symbolique Automatique Agents Cognitifs et Apprentissage Symbolique Automatique Equipe de Recherche en Signal et Imagerie Medicale Epidémiologie des maladies infectieuses et modélisation

---

Résumé : The sleep apnea syndrome is a real public health problem. Improving its diagnosis using the polysomnography is of huge importance. Optisas was a visual method allowing translating the polysomnographic data into a meaningful image. In a previous paper, it was shown to bring extra information in 62% of cases. Here its capacity for displaying information of the same relevance as the one got using the classical report of the polysomnography is studied. The main result is that this capacity is weak and seems to be present only to identify the obstructive sleep apnea syndrome. Moreover this study suggests to improve the standardization of the classical report in the framework of a quality insurance process.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Julie DumontDjabaria MeroufelChristophe BautersFranck HansmannelFaïza BensemainDominique CottelMartial HamonJean-Charles LambertPierre DucimetièrePhilippe AmouyelMahmoud ZureikThierry Brousseau
• Organismes : Institut Pasteur de Lille Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Laboratoire de Génétique Moléculaire et Cellulaire Hôpital cardiologique Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations Institut Pasteur de Lille Institut Pasteur de Lille Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Biomolécules et inflammation pulmonaire CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Institut Pasteur de Lille Recherche en épidémiologie et biostatistique Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Institut Pasteur de Lille Comité consultatif sur le traitement de l'information en matière de recherche dans le domaine de la santé Biochimie Automatisée [Lille] Institut Pasteur de Lille Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans American Journal of Hypertension le 26/10/2020

---

Résumé : Background: Previous studies have suggested that the activity of enzymes involved in the urea cycle may modulate nitric oxide (NO) production, arterial vasomotion, and hypertension. Our aim was to determine whether hypertension and coronary vasomotion could be associated with polymorphisms within the ornithine transcarbamylase (OTC) gene, located on chromosome X and coding for a key-enzyme of the urea cycle. Methods: Among 11 OTC polymorphisms that were originally selected from databases, the tag single-nucleotide polymorphism (SNP) rs5963409 and the independent SNP rs1800321 were tested for association with hypertension in two independent population samples recruited in Northern (Multinational MONItoring of trends and determinants in CArdiovascular disease (MONICA) study, n = 1,138) and Western (Etude du Vieillissement Artériel (EVA) study, n = 1,166) France. The vasomotor response of coronary arteries to methylergonovine maleate and isosorbide dinitrate was also evaluated in an independent sample (the vasomotion study, n = 121). Results: In males, the frequency of the rs5963409 minor allele was consistently higher in hypertensive (HT) than in normotensive subjects in the MONICA and EVA studies. In the combined sample, the rs5963409 minor allele was associated with an increased risk of hypertension (odds ratio (OR) (95% confidence interval (CI)) = 1.45 (1.10-1.90); P = 0.008). This association was independent of classical confounding factors. Consistently, rs5963409 minor allele was associated with a greater susceptibility to vasoconstriction in response to methylergonovine maleate (P = 0.0072). In contrast, no significant association between rs5963409 and hypertension could be detected in females. Conclusion: Our results suggest that the OTC rs5963409 polymorphism may be associated with hypertension and coronary vasomotion in males.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Philippe Bourmaud
• Organismes : Religions et croyances
• Publié dans Vingtième siècle. Revue d'histoire le 24/10/2020

---

Résumé : Pour mieux situer les discriminations subies par les Palestiniens aujourd'hui, il est utile de remonter dans le temps, jusqu'à l'Empire ottoman et aux mandats de la SDN : on mesure ainsi l'ancienneté des deux dimensions, territoriale et identitaire, qui ont structuré de telles pratiques dans l'ensemble du Proche-Orient.

---

Fichiers liés : Article_20e_siA_cle_-_Septembre_2008_-_3.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Philippe DubuissonRobert FrouinDavid DessaillyLucile Duforêt-GaurierJean François LéonKenneth VossDavid Antoine
• Organismes : Laboratoire d’Optique Atmosphérique - UMR 8518 Scripps Institution of Oceanography Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Ecosystèmes littoraux et côtiers Université du Littoral Côte d'Opale Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Ecosystèmes littoraux et côtiers Université du Littoral Côte d'Opale Laboratoire d’Optique Atmosphérique - UMR 8518 University of Miami Laboratoire d'océanographie de Villefranche
• Publié dans Remote Sensing of Environment le 28/10/2020

---

Résumé : A methodology is proposed to infer the altitude of aerosol plumes over the ocean from reflectance ratio measurements in the O2 absorption A-band (759 to 770 nm). The reflectance ratio is defined as the ratio of the reflectance in a first spectral band, strongly attenuated by O2 absorption, and the reflectance in a second spectral band, minimally attenuated. For a given surface reflectance, simple relations are established between the reflectance ratio and the altitude of an aerosol layer, as a function of atmospheric conditions and the geometry of observation. The expected accuracy for various aerosol loadings and models is first quantified using an accurate, high spectral resolution, radiative transfer model that fully accounts for interactions between scattering and absorption. The method is developed for POLDER and MERIS, satellite sensors with adequate spectral characteristics. The simulations show that the method is only accurate over dark surfaces when aerosol optical thickness at 765 nm is relatively large (> 0.3). In this case, the expected accuracy is on the order of ± 0.5 km or ± 0.2 km for POLDER or MERIS respectively. More accurate estimates are obtained with MERIS, since in this case the spectral reflectance ratio is more sensitive to aerosol altitude. However, a precise spectral calibration is needed for MERIS. The methodology is applied to MERIS and POLDER imagery acquired over marine surfaces. The estimated aerosol altitude is compared with in situ lidar profiles of backscattering coefficient measured during the AOPEX-2004 experiment for MERIS, or obtained with the space-borne lidar CALIOP for POLDER. The retrieved altitudes agree with lidar measurements in a manner consistent with theory. These comparisons demonstrate the potential of the differential absorption methodology for obtaining information on aerosol altitude over dark surfaces.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Jean-Pierre LevraudOlivier DissonKarima KissaIsabelle BonnePascale CossartPhilippe HerbomelMarc Lecuit
• Organismes : Macrophages et Développement de l'Immunité Microorganismes et Barrières de l'Hôte Macrophages et Développement de l'Immunité Microscopie ultrastructurale (plate-forme) Interactions Bactéries-Cellules Macrophages et Développement de l'Immunité Microorganismes et Barrières de l'Hôte Université Paris Descartes - Paris 5
• Publié dans Infection and Immunity le 27/10/2020

---

Résumé : ABSTRACT The zebrafish, Danio rerio , has become a popular vertebrate model for the study of infections, mainly because of its excellent optical accessibility at the embryonic and larval stages, when the innate immune system is already effective. We have thus tested the susceptibility of zebrafish larvae to the human pathogen Listeria monocytogenes , a gram-positive, facultative, intracellular bacterium that is known to survive and multiply in professional phagocytes and that causes fatal meningitis and abortions. Intravenous injection of early zebrafish larvae resulted in a progressive and ultimately fatal infection. Blood-borne L. monocytogenes bacteria were quickly trapped and engulfed by macrophages, an event that, for the first time, could be captured in vivo and in real time. Granulocytes also participated in the innate immune response. As in mammals, bacteria could escape the macrophage phagosome in a listeriolysin-dependent manner and accessed the cytosol; this event was critical for bacterial virulence, as listeriolysin-deficient bacteria were completely avirulent. Actin comet tails and protrusions were observed, suggesting cell-to-cell spread; these phenomena also played a role in virulence in zebrafish larvae, as actA -deficient bacteria were attenuated. These results demonstrate the relevance of the genetically tractable and optically accessible zebrafish model for the study of L. monocytogenes pathogenesis and particularly for the dissection of its interactions with phagocytes in vivo, a key factor of L. monocytogenes virulence.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Stéphanie SahuguedeD. FafchampsAnne Julien-VergonjanneG. RodriguezJean-Pierre CancesPhilippe Gallion
• Organismes : C2S2 Télécommunications Optiques Communications Numériques Département Communications & Electronique C2S2 Communications Numériques Département Communications & Electronique C2S2 Télécommunications Optiques Département Communications & Electronique
• Publié dans IEEE Photonics Technology Letters le 26/10/2020

---

Résumé : Without being restrictive, optical signal propagation simulations performed in the case of a new concept of packet ring network pointed out that the Gaussian model is not sufficiently accurate to constitute a valuable model of noise-corrupted optical systems. This fact can be generalized to any common wavelength-division-multiplexing systems, using on-off keying transmissions where amplified spontaneous emission is the main noise source. In this letter, we propose an alternative chi-square model, which is more accurate and corrects deficiencies of the Gaussian model. In such specific channel, we design an error-correcting scheme based on low-density parity check (LDPC) codes associated to soft decoding. The performance of a chi-square-based LDPC soft decoder and a Gaussian-based one are compared, both applied to a real chi-square optical channel. We point out that the design can be done assuming an additive white Gaussian noise statistic but also that considering the real channel statistics is essential to achieve optimal performance.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Jean-Philippe TardifPeter SturmMartin TrudeauSébastien Roy
• Organismes : Département d'Informatique et de Recherche Opérationnelle [Montreal] Interpretation and Modelling of Images and Videos Département d'Informatique et de Recherche Opérationnelle [Montreal] Département d'Informatique et de Recherche Opérationnelle [Montreal]
• Publié dans IEEE Transactions on Pattern Analysis and Machine Intelligence le 31/10/2020

---

Résumé : We present algorithms for plane-based calibration of general radially distorted cameras. By this we understand cameras that have a distortion center and an optical axis such that the projection rays of pixels lying on a circle centered on the distortion center, form a right viewing cone centered on the optical axis. The camera is said to have a single viewpoint (SVP) if all such viewing cones have the same apex (the optical center), otherwise we speak of NSVP cases. This model encompasses the classical radial distortion model [4], fisheyes and most central or non-central catadioptric cameras. Calibration consists in the estimation of the distortion center, the opening angles of all viewing cones and their optical centers. We present two approaches of computing a full calibration from dense correspondences of a single or multiple planes with known Euclidean structure. The first one is based on a geometric constraint linking viewing cones and their intersections with the calibration plane (conic sections). The second approach is an homography-based method. Experiments using simulated and a broad variety of real cameras show great stability. Furthermore, we provide a comparison with Hartley-Kang's algorithm [14], which however can not handle such a broad variety of camera configurations, showing similar performance.

---

Fichiers liés : TardifSturmTrudeauRoy-PAMI2008.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : J.C. EspinozaJean Loup GuyotJosyane RonchailGérard CochonneauNaziano FilizolaPascal FraizyDavid LabatEurides de OliveiraJuan Julio OrdoñezPhilippe Vauchel
• Organismes : Universidad Nacional Agraria La Molina Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Institut de Recherche pour le Développement Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Institut de Recherche pour le Développement Universidade do Estado do Amazonas = University of the Amazon State Institut de Recherche pour le Développement Université Toulouse III - Paul Sabatier Agencia Nacional de Águas SENAMHI LIMA PER Institut de Recherche pour le Développement
• Publié dans Journal of Hydrology le 23/10/2020

---

Source