Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Philippe DubuissonRobert FrouinDavid DessaillyLucile Duforêt-GaurierJean François LéonKenneth VossDavid Antoine
• Organismes : Laboratoire d’Optique Atmosphérique - UMR 8518 Scripps Institution of Oceanography Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Ecosystèmes littoraux et côtiers Université du Littoral Côte d'Opale Laboratoire d’Océanologie et de Géosciences (LOG) - UMR 8187 Ecosystèmes littoraux et côtiers Université du Littoral Côte d'Opale Laboratoire d’Optique Atmosphérique - UMR 8518 University of Miami Laboratoire d'océanographie de Villefranche
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : A methodology is proposed to infer the altitude of aerosol plumes over the ocean from reflectance ratio measurements in the O2 absorption A-band (759 to 770 nm). The reflectance ratio is defined as the ratio of the reflectance in a first spectral band, strongly attenuated by O2 absorption, and the reflectance in a second spectral band, minimally attenuated. For a given surface reflectance, simple relations are established between the reflectance ratio and the altitude of an aerosol layer, as a function of atmospheric conditions and the geometry of observation. The expected accuracy for various aerosol loadings and models is first quantified using an accurate, high spectral resolution, radiative transfer model that fully accounts for interactions between scattering and absorption. The method is developed for POLDER and MERIS, satellite sensors with adequate spectral characteristics. The simulations show that the method is only accurate over dark surfaces when aerosol optical thickness at 765 nm is relatively large (> 0.3). In this case, the expected accuracy is on the order of ± 0.5 km or ± 0.2 km for POLDER or MERIS respectively. More accurate estimates are obtained with MERIS, since in this case the spectral reflectance ratio is more sensitive to aerosol altitude. However, a precise spectral calibration is needed for MERIS. The methodology is applied to MERIS and POLDER imagery acquired over marine surfaces. The estimated aerosol altitude is compared with in situ lidar profiles of backscattering coefficient measured during the AOPEX-2004 experiment for MERIS, or obtained with the space-borne lidar CALIOP for POLDER. The retrieved altitudes agree with lidar measurements in a manner consistent with theory. These comparisons demonstrate the potential of the differential absorption methodology for obtaining information on aerosol altitude over dark surfaces.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Philippe NubukpoPaola RevueCecil HerrmannJean-Pierre Clément
• Organismes : Neuroépidémiologie Tropicale et Comparée Centre de Mémoire de Ressources et de Recherches [Limoges] Hôpital Psychiatrique La Valette Neuroépidémiologie Tropicale et Comparée Service de Psychiatrie [CHU Limoges]
• Publié dans Psychologie & neuropsychiatrie du vieillissement le 13/08/2014

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Résumé : Ethnopsychiatry is defined as an approach aimed to understand the ethnic and cultural dimensions of mental illnesses. The triple interest of cross-cultural approach in psychiatry in the elderly is highlighted by a review of the literature and five clinical vignettes. The first interest is to help the diagnosis of mental disorders in aged immigrants. The second is to take into account the ethnopsychogeriatric specificities by the sanitary and social systems. The third involves some aspects of psychiatry in the elderly in Sub-Saharan Africa. With aging, the immigrant has to reinvent, successfully or not, new rationalizations of his/her presence. Moreover, he/she often presents a premature physical over-deterioration linked to difficult existing conditions. Caring for the elderly from an ethnopsychiatric approach supposes firstly, to grant him correct life and physical health conditions; secondly, training of professionals to consider their specific cultural dimensions and at last, adapting the care and help services. Ethnopsychiatry or cultural psychiatry in the elderly must take into account the social and cultural representations of the diseases. Presently, depression among the elderly is common in Africa and dementia is not rare.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : Marie-Paule BeaujardSandra Chantot-BastaraudMichèle DuboisBoris KerenWassila CarpentierPhilippe MabbouxSandra WhalenMichel VodovarJean-Pierre SiffroiMarie-France Portnoi
• Organismes : CHU Trousseau [APHP] CHU Pitié-Salpêtrière [AP-HP] Plateforme Post-génomique de la Pitié-Salpêtrière Université Pierre et Marie Curie - Paris 6 CHU Trousseau [APHP] CHU Trousseau [APHP] CHU Trousseau [APHP] CHU Trousseau [APHP]
• Publié dans European Journal of Medical Genetics le 22/10/2020

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Résumé : Despite the heterogeneous clinical presentations, the majority of patients with 22q11.2 deletion syndrome (22q11.2 DS) have either a common recurrent 3 Mb deletion or a less common, 1.5 Mb nested deletion, with breakpoint sites in flanking low-copy repeats (LCR) sequences. Only a small number of atypical deletions have been reported and precisely defined. Haploinsufficiency of the TBX1 gene was determined to be the likely cause of 22q11.2 DS. The diagnostic procedure usually used is FISH using commercially probes (N25 or TUPLE1). However, this test does not contain TBX1, and fails to detect deletions that are either proximal or distal to the FISH probes. Here, we report on two patients with clinical features suggestive of 22q11.2 DS, a male infant with facial dysmorphia, pulmonary atresia, ventricular septal defect, neonatal hypocalcemia, and his affected mother, with facial dysmorphia, learning disabilities, and hypernasal speech. They were tested negative for 22q11.2 DS using N25 or TUPLE1 probes, but were shown deleted for a probe containing TBX1. Delineation of the deletion was performed using high-density SNP arrays (Illumina, 370K). This atypical deletion was spanning 1.89 Mb. The distal breakpoint resided in LCR-D, sharing the same distal breakpoint with the 3 Mb common deletion. The proximal breakpoint was located 105 kb telomeric to TUPLE1, representing a new breakpoint variant that does not correspond to known LCRs of 22q11.2. We conclude that FISH with the TBX1 probe is an accurate diagnostic tool for 22q11.2 DS, with a higher sensitivity than FISH using standard probes, detecting all but the rarest deletions, greatly reducing the false negative rate.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2009
• Auteurs : J.C. EspinozaJosyane RonchailJean Loup GuyotGérard CochonneauFilizola NazianoWaldo LavadoEurides de OliveiraRodrigo PombosaPhilippe Vauchel
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Université Paris Diderot - Paris 7 Agencia Nacional de Águas
• Publié dans International Journal of Climatology le 31/10/2020

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Résumé : Not Available

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/09/2009
• Auteurs : Léonide CeliniVirginie RoyEdouard MiambiPhilippe MoraCorinne RoulandL. AurelaF. GuiriaboyeC. JacobyJean VaillantGladys Loranger-Merciris
• Organismes : Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Laboratoire de Mathématiques Informatique et Applications Biodiversité et fonctionnement des sols

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Résumé : Acromyrmex octospinosus (Reich), est une fourmi champignonniste qui vit dans un nid souterrain en symbiose avec un champignon du genre Leucoagrinus. Elle est la seule espèce du genre Acromyrmex recensée en Guadeloupe et est appelée " Fourmi manioc". C'est une espèce invasive; découverte en 1954, dans une seule localité, elle est présente dans presque toute la totalité de l'île. Fourmi défoliatrice, elle s'attaque à de nombreuses cultures (vivrières, fruitières,....) et actuellement, elle représente un danger pour certaines espèces patrimoniales et des essences forestières. L'objectif du projet est de proposer des solutions de lutte efficaces mais respectueuses de la santé et de l'environnement et qui s'intègrent dans un schéma de développent durable de la Guadeloupe.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 31/08/2009
• Auteurs : Bruno PaganoOlivier AndrieuThomas MoniotBenjamin CanouEmmanuel ChaillouxPhilippe WangPascal ManouryJean-Louis Colaço
• Organismes : Algorithmes, Programmes et Résolution Algorithmes, Programmes et Résolution Algorithmes, Programmes et Résolution Preuves, Programmes et Systèmes

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Résumé : High-level tools have become unavoidable in industrial software development processes. Safety-critical embedded programs don't escape this trend. In the context of safety-critical embedded systems, the development processes follow strict guidelines and requirements. The development quality assurance applies as much to the final embedded code, as to the tools themselves. The French company Esterel Technologies decided in 2006 to base its new SCADE SUITE 6TM certifiable code generator on Objective Caml. This paper outlines how it has been challenging in the context of safety critical software development by the rigorous norms DO-178B, IEC 61508, EN 50128 and such.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/08/2009
• Auteurs : Nicolas Chemidlin Prévost-BouréSamuel DequiedtRémy DoyenMélanie M. LelievreClaudy JolivetManuel P MartinNicolas P. A. SabyBenoit ToutainDominique ArrouaysJérôme HarmandPatrice LoiselJean ThioulousePierre-Alain MaronPhilippe LemanceauLionel Ranjard
• Organismes : Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement InfoSol InfoSol InfoSol InfoSol InfoSol Laboratoire de Biotechnologie de l'Environnement [Narbonne] Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement

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Résumé : absent

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/08/2009
• Auteurs : Samuel DequiedtMélanie M. LelievreClaudy JolivetManuel P MartinNicolas P. A. SabyBenoit ToutainDominique ArrouaysNicolas Chemidlin Prévost-BouréJérôme HarmandPatrice LoiselJean ThioulousePierre-Alain MaronPhilippe LemanceauLionel Ranjard
• Organismes : Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement InfoSol InfoSol InfoSol InfoSol InfoSol Microbiologie du Sol et de l'Environnement Laboratoire de Biotechnologie de l'Environnement [Narbonne] Mathématiques, Informatique et STatistique pour l'Environnement et l'Agronomie SDAR Occitanie Montpellier Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement Microbiologie du Sol et de l'Environnement

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Résumé : absent

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• Type de publi. : Article dans une revue
• Date de publi. : 27/08/2009
• Auteurs : Delphine Destoumieux-GarzonMichel BrehélinPhilippe BuletYvan BoublikPierre-Alain GirardStephen BaghdiguianRobert ZumbihlJean-Michel Escoubas
• Organismes : Ecologie des systèmes marins côtiers Institut Français de Recherche pour l'Exploitation de la Mer Université Montpellier 2 - Sciences et Techniques Ecologie microbienne des insectes et interactions hôte-pathogène Centre National de la Recherche Scientifique Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Centre de recherche en Biologie Cellulaire Ecologie microbienne des insectes et interactions hôte-pathogène Écologie et santé des écosystèmes Institut des Sciences de l'Evolution de Montpellier Ecologie microbienne des insectes et interactions hôte-pathogène Université Montpellier 2 - Sciences et Techniques Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier]
• Publié dans PLoS ONE le 25/10/2020

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Résumé : Background: X-tox proteins are a family of immune-related proteins only found in Lepidoptera and characterized by imperfectly conserved tandem repeats of several defensin-like motifs. Previous phylogenetic analysis of X-tox genes supported the hypothesis that X-tox have evolved from defensins in a lineage-specific gene evolution restricted to Lepidoptera. In this paper, we performed a protein study in which we asked whether X-tox proteins have conserved the antimicrobial functions of their ancestral defensins and have evolved as defensin reservoirs. Methodology/Principal Findings: We followed the outcome of Spod-11-tox, an X-tox protein characterized in Spodoptera frugiperda, in bacteria-challenged larvae using both immunochemistry and antimicrobial assays. Three hours post infection, the Spod-11-tox protein was expressed in 80% of the two main classes of circulating hemocytes (granulocytes and plasmatocytes). Located in secretory granules of hemocytes, Spod-11-tox was never observed in contact with microorganisms entrapped within phagolyzosomes showing that Spod-11-tox is not involved in intracellular pathogen killing. In fact, the Spod-11-tox protein was found to be secreted into the hemolymph of experimentally challenged larvae. In order to determine antimicrobial properties of the Spod-11-tox protein, it was consequently fractionated according to a protocol frequently used for antimicrobial peptide purification. Over the course of purification, the anti-Spod-11-tox immunoreactivity was found to be dissociated from the antimicrobial activity. This indicates that Spod-11-tox is not processed into bioactive defensins in response to a microbial challenge. Conclusions/Significance: Altogether, our results show that X-tox proteins have not evolved as defensin reservoirs and have lost the antimicrobial properties of the ancestral insect defensins. The lepidopteran X-tox protein family will provide a valuable and tractable model to improve our knowledge on the molecular evolution of defensins, a class of innate immune effectors largely distributed over the three eukaryotic kingdoms

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Fichiers liés : 37148_20100914113340568_1.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/08/2009
• Auteurs : Jean-Philippe AntoniPierre FrankhauserGilles Vuidel
• Organismes : Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049) Théoriser et modéliser pour aménager (UMR 6049)

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