Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/06/2009
• Auteurs : Anne HémeryckJean-Marie DucereAlain EstèveMehdi Djafari RouhaniGeorges LandaCyril TropisPhilippe MeniniAndré MaisonnatPierre FauBruno Chaudret
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination

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Résumé : Metal oxides such as tin oxide (SnO 2) are widely used for gas sensing applications, particularly in environmental applications. The change in the resistance of the sensing layer is the detection principle of the gas sensors. The variations of the resistance are due to the charge transfers resulting from the chemical reactions which occur at the surface of the tin dioxide sensitive layer. In this work, a multiscale approach is developed in order to model interactions of SnO 2 with various gases, such as CO and CO 2. Ab initio calculations are systematically used to identify and characterize, at the atomic scale, the chemical reactions occurring at the surface of the sensitive layer of the sensor. Structures and activation energies associated to surface reactions, and charge transfers characteristics of each surface species, are determined. To simulate the sensors behaviour on a wider scale, a mesoscopic model based on the ab initio results and a chemical rate theory technique is developed. This model gives the temporal evolution of the sensors response as a function of external parameters. This methodology, combining ab initio calculations and mesoscopic model, leads to a better understanding of the macroscopic gas sensor behaviour. We identify the SnO 2 reduction by CO, the catalytic oxidation mechanism of CO involving successive reduction and reoxidation of the oxide layer and the tricky detection of CO 2 gas as a function of external parameters like humidity.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 03/06/2009
• Auteurs : Maxime SermesantFlorence BilletRadomir ChabiniokTommaso MansiPhani ChinchapatnamPhilippe MoireauJean-Marc PeyratKawal S. RhodeMatt GinksPier LambiaseSimon ArridgeHervé DelingetteMichel SorineC.A. RinaldiDominique ChapelleReza RazaviNicholas Ayache
• Organismes : Analysis and Simulation of Biomedical Images Analysis and Simulation of Biomedical Images Modelling, Simulation, Control and Optimization of Non-Smooth Dynamical Systems Modeling, analysis and control in computational structural dynamics Analysis and Simulation of Biomedical Images Centre for Medical Image Computing Modeling, analysis and control in computational structural dynamics Analysis and Simulation of Biomedical Images Division of Imaging Sciences Division of Imaging Sciences The Heart Hospital [London] Centre for Medical Image Computing Analysis and Simulation of Biomedical Images SIgnals and SYstems in PHysiology & Engineering Department of cardiology [Guy's and St. Thomas ' hospitals] [London] Modeling, analysis and control in computational structural dynamics Division of Imaging Sciences NIHR Biomedical Research Centre [London] Analysis and Simulation of Biomedical Images

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Résumé : Cardiac resynchronisation therapy (CRT) has been shown to be an effective adjunctive treatment for patients with dyssynchronous ventricular contraction and symptoms of the heart failure. However, clinical trials have also demonstrated that up to 30% of patients may be classified as non-responders. In this article, we present how the personalisation of an electromechanical model of the myocardium could help the therapy planning for CRT. We describe the four main components of our myocardial model, namely the anatomy, the electrophysiology, the kinematics and the mechanics. For each of these components we combine prior knowledge and observable parameters in order to personalise these models to patient data. Then the acute effects of a pacemaker on the cardiac function are predicted with the in silico model on a clinical case. This is a proof of concept of the potential of virtual physiological models to better select and plan the therapy.

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• Type de publi. : Rapport
• Date de publi. : 03/06/2009
• Auteurs : Reto KrummenacherIoan TomaChristophe HamerlingJean-Pierre LorreFrançoise BaudeVirginie LegrandPhilippe MerleCristian RuzCarlos PedrinaciDong LiuTomas Pariente Lobo
• Organismes : Active objects, semantics, Internet and security Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis Adaptive Distributed Applications and Middleware Active objects, semantics, Internet and security Knowledge Media Institute Knowledge Media Institute

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Edouard TuaillonDiane ValéaPierre BecquartYassine Al TabaaNicolas MedaKarine BollorePhilippe van de PerreJean-Pierre Vendrell
• Organismes : Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Centre Muraz [Bobo-Dioulasso, Burkina Faso] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Centre Muraz [Bobo-Dioulasso, Burkina Faso] Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Laboratoire de Virologie [CHRU Montpellier] Pathogénèse et contrôle des infections chroniques (PCCI) Institut de recherche en biothérapie
• Publié dans Journal of Immunology le 27/10/2020

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Résumé : While secretory Abs have been extensively explored in human breast milk, the existence, features, and functions of B lymphocytes remain largely unexplored in this compartment. We analyzed breast milk and blood lymphocytes from 21 lactating women, including 12 HIV-1-infected mothers. Breast milk B cells displayed a phenotype of class-switched memory B cells, with few IgD+ memory and naive B cells. We observed that breast milk B lymphocytes bore a unique profile of adhesion molecules (CD44+, CD62L−, α4β7+/−, α4β1+). Higher percentages of activated B cells (CD38+), large-sized B cells, plasmablasts, and plasma cells (CD19+, CD20low/−, CD27high, CD138+) were found as compared with blood. This indicates that a significant proportion of breast milk B cells underwent terminal plasma cell differentiation. We also observed a higher frequency of cells secreting Ig spontaneously in breast milk. Among these cells, IgG-secreting cells predominated over IgA-secreting cells as measured by Ig ELISPOT assays. Specific Ab-secreting cells were investigated following polyclonal activation using the CD40L ligation. Finally, the detection of anti-HIV-1-secreting cells demonstrates the existence of B cells specific to HIV-1 Ag in breast milk from HIV-1-infected women. Breast milk B cells display a phenotype strikingly different from blood, are primed to secrete Abs, and have a mucosal homing profile similar to B cells located in gut-associated lymphoid tissue.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Philippe Jean-BaptisteElise FourréJean-Luc CharlouJean-Pierre DonvalThierry Corrège
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Glaces et Continents, Climats et Isotopes Stables
• Publié dans Estuarine, Coastal and Shelf Science le 22/10/2020

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Fichiers liés : publication-6457.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Estelle EscudierPhilippe DuquesnoyJean-François PaponSerge Amselem
• Organismes : Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP] Institut Mondor de Recherche Biomédicale Physiopathologie des maladies génétiques d'expression pédiatrique CHU Trousseau [APHP]
• Publié dans Paediatric Respiratory Reviews le 02/11/2020

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Résumé : Cilia are evolutionarily conserved structures that play key roles in diverse cell types. Motile cilia are involved in the most prominent ciliopathy called primary ciliary dyskinesia (PCD) that combines respiratory symptoms, male infertility, and, in nearly 50% cases, situs inversus. The diagnosis of PCD relies on the identification of ciliary abnormalities that mainly concern outer and/or inner dynein arms (ODA, IDA). PCD is a genetic condition, usually inherited as an autosomal recessive trait. To date, six genes have been clearly implicated in PCD. Two "major" genes, DNAI1 and DNAH5, underlie PCD in nearly half of the patients with ODA defects, whereas RPGR, DNAH11 and TXNDC3 are implicated in rare families with specific phenotypes (retinitis pigmentosa, abnormal beating of structurally normal cilia, and situs ambiguous, respectively). The relative contribution of DNAI2 is currently being assessed. In all the other patients with ODA or other ultrastructural defects, the causative genes remain to be identified.

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Fichiers liés : PCD_Review_Escudier.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Marie-Pierre ChauzatPatrice CarpentierAnne-Claire MartelStéphanie BougeardNicolas CougoulePhilippe PortaJulie LachaizeFrançois MadecMichel AubertJean-Paul Faucon
• Organismes : Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Direction du végétal et de l'environnement Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches avicoles, porcines et piscicoles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches avicoles, porcines et piscicoles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles Laboratoire d'études et de recherches sur les petits ruminants et les abeilles
• Publié dans Environmental Entomology le 24/10/2020

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Résumé : A 3-yr field survey was carried out in France, from 2002 to 2005, to study honey bee (Apis mellifera L.) colony health in relation to pesticide residues found in the colonies. This study was motivated by recent massive losses of honey bee colonies, and our objective was to examine the possible relationship between low levels of pesticide residues in apicultural matrices (honey, pollen collected by honey bees, beeswax) and colony health as measured by colony mortality and adult and brood population abundance. When all apicultural matrices were pooled together, the number of pesticide residue detected per sampling period (four sampling periods per year) and per apiary ranged from 0 to 9, with the most frequent being two (29.6%). No pesticide residues were detected during 12.7% of the sampling periods. Residues of imidacloprid and 6- chloronicotinic acid were the most frequently detected in pollen loads, honey, and honey bee matrices. Several pairs of active ingredients were present concurrently within honey bees and in pollen loads but not in beeswax and honey samples. No statistical relationship was found between colony mortality and pesticide residues. When pesticide residues from all matrices were pooled together, a mixed model analysis did not show a significant relationship between the presence of pesticide residues and the abundance of brood and adults, and no statistical relationship was found between colony mortality and pesticide residues. Thus, although certain pesticide residues were detected in apicultural matrices and occasionally with another pesticide residual, more work is needed to determine the role these residues play in affecting colony health.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : France Tuffery-GiraudChristophe BéroudFrance LeturcqRabah Ben YaouDalil HamrounLaurence Michel-CalemardPierre MoizardRafaelle BernardMireille CosséePierre BoisseauMartine BlayauIsabelle CreveauxAnne Guiochon-MantelBérengère de MartinvillePhilippe PhilippeNicole MonnierEric BiethPhilippe KHAU VAN KIENFrançois-Olivier DesmetVéronique HumbertclaudeJean-Claude KaplanJamel ChellyMireille ClaustresSylvie Tuffery-GiraudChristophe PhilippePhilippe Khau van Kien
• Organismes : Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Service de biochimie et de génétique moléculaire [CHU Cochin] Institut de génétique humaine Centre de biologie et pathologie Est Génétique Médicale et Génomique Fonctionnelle Service de génétique médicale Physiopathologie et pharmacologie cellulaires et moléculaires Service de génétique clinique [Rennes] Laboratoire de Biochimie Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique Canaux calciques , fonctions et pathologies Service Génétique Médicale [CHU Toulouse] Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Institut de génétique humaine Laboratoire de Biochimie et Génétique Moléculaire Human Molecular Genetics Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique des maladies rares. Pathologie moleculaire, etudes fonctionnelles et banque de données génétiques Laboratoire de génétique Centre Hospitalier Universitaire de Nîmes
• Publié dans Human Mutation le 26/10/2020

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Résumé : UMD-DMD France is a knowledgebase developed through a multicenter academic effort to provide an up-to-date resource of curated information covering all identified mutations in patients with a dystrophinopathy. The current release includes 2,411 entries consisting in 2,084 independent mutational events identified in 2,046 male patients and 38 expressing females, which corresponds to an estimated number of 39 people per million with a genetic diagnosis of dystrophinopathy in France. Mutations consist in 1,404 large deletions, 215 large duplications, and 465 small rearrangements, of which 39.8% are nonsense mutations. The reading frame rule holds true for 96% of the DMD patients and 93% of the BMD patients. Quality control relies on the curation by four experts for the DMD gene and related diseases. Data on dystrophin and RNA analysis, phenotypic groups, and transmission are also available. About 24% of the mutations are de novo events. This national centralized resource will contribute to a greater understanding of prevalence of dystrophinopathies in France, and in particular, of the true frequency of BMD, which was found to be almost half (43%) that of DMD. UMD-DMD is a searchable anonymous database that includes numerous newly developed tools, which can benefit to all the scientific community interested in dystrophinopathies. Dedicated functions for genotype-based therapies allowed the prediction of a new multiexon skipping (del 45-53) potentially applicable to 53% of the deleted DMD patients. Finally, such a national database will prove to be useful to implement the international global DMD patients' registries under development.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Gilles PaintaudJean-Camille MericDenis MullemanEmilie DucourauCharlotte Magdelaine-BeuzelinJean-Pierre ValatPhilippe Goupille
• Organismes : Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011]
• Publié dans Fundamental & Clinical Pharmacology le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2009
• Auteurs : Barbara BournetAnny SouquePierre SenesseEric AssenatMarc BarthetNathalie LesavreAriane AubertDermot O'ToolePascal HammelPhilippe LevyPhilippe RuszniewskiMichèle BouissonJean EscourrouPierre CordelierLouis Buscail
• Organismes : Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil CRLCC Val d'Aurelle - Paul Lamarque CRLCC Val d'Aurelle - Paul Lamarque Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Department of Gastroenterology Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil Pôle Maladies de l'appareil digestif [CHU Toulouse] Institut de médecine moléculaire de Rangueil
• Publié dans Endoscopy le 22/10/2020

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Résumé : BACKGROUND AND STUDY AIMS: Differential diagnosis between pancreatic adenocarcinoma (PADC) and pseudotumoral forms of chronic pancreatitis remains difficult. Mutation of KRAS oncogene is present in 75% to 95% of PADC. This study aimed to evaluate whether the combined analysis of KRAS mutation with cytopathological findings from endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) might improve discrimination between PADC and chronic pancreatitis. PATIENTS AND METHODS: This prospective multicenter study included 178 patients with solid pancreatic masses (men 104, women 74; mean age 64.5 years). Cytopathological examination and KRAS mutation analysis (codon-12 and codon-13, restriction fragment length polymorphism [RFLP] and direct sequencing) were performed on EUS-FNAB material. Final diagnoses were obtained on EUS-FNAB analysis and/or a second biopsy and/or clinical follow-up and/or surgery: PADC, n = 129; chronic pancreatitis, n = 27; other pancreatic neoplasms, n = 16; and benign lesions, n = 6. RESULTS: KRAS status analysis was successful in all EUS-FNAB samples. Codon-12 KRAS point mutation was found in 66% of PADC samples. No case of chronic pancreatitis displayed KRAS mutation. Sensitivity, specificity, positive and negative predictive values, and overall accuracy of cytopathology alone for diagnosis of PADC versus chronic pancreatitis were 83%, 100%, 100%, 56% and 86%, respectively. When KRAS mutation analysis was combined with cytopathology, these values reached 88%, 100%, 100%, 63% and 90% respectively. CONCLUSION: Although the value of KRAS analysis in addition to EUS-FNAB is limited for distinguishing pancreatic mass lesions, when chronic pancreatitis presented as a pseudotumor a negative finding (wild-type KRAS), was useful in strongly suggesting a benign lesion.

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